Manipulation of host hepatocytes by the malaria parasite for delivery into liver sinusoids.

Sturm, Angelika; Amino, Rogerio; van de Sand, Claudia; Regen, Tommy; Retzlaff, Silke; Rennenberg, Annika; Krueger, Andreas; Pollok, Jörg-Matthias; Menard, Robert; Heussler, Volker (2006). Manipulation of host hepatocytes by the malaria parasite for delivery into liver sinusoids. Science, 313(5791), pp. 1287-1290. American Association for the Advancement of Science 10.1126/science.1129720

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The merozoite stage of the malaria parasite that infects erythrocytes and causes the symptoms of the disease is initially formed inside host hepatocytes. However, the mechanism by which hepatic merozoites reach blood vessels (sinusoids) in the liver and escape the host immune system before invading erythrocytes remains unknown. Here, we show that parasites induce the death and the detachment of their host hepatocytes, followed by the budding of parasite-filled vesicles (merosomes) into the sinusoid lumen. Parasites simultaneously inhibit the exposure of phosphatidylserine on the outer leaflet of host plasma membranes, which act as "eat me" signals to phagocytes. Thus, the hepatocyte-derived merosomes appear to ensure both the migration of parasites into the bloodstream and their protection from host immunity.

Item Type:

Journal Article (Original Article)

Division/Institute:

08 Faculty of Science > Department of Biology > Institute of Cell Biology > Malaria
08 Faculty of Science > Department of Biology > Institute of Cell Biology

UniBE Contributor:

Heussler, Volker

Subjects:

500 Science > 570 Life sciences; biology

ISSN:

0036-8075

Publisher:

American Association for the Advancement of Science

Language:

English

Submitter:

Volker Heussler

Date Deposited:

06 Jul 2016 11:42

Last Modified:

07 Jul 2016 04:34

Publisher DOI:

10.1126/science.1129720

PubMed ID:

16888102

BORIS DOI:

10.7892/boris.84078

URI:

https://boris.unibe.ch/id/eprint/84078

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