Live and let die: manipulation of host hepatocytes by exoerythrocytic Plasmodium parasites

Sturm, Angelika; Heussler, Volker (2007). Live and let die: manipulation of host hepatocytes by exoerythrocytic Plasmodium parasites. Medical microbiology and immunology, 196(3), pp. 127-133. Springer 10.1007/s00430-007-0044-3

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The generation of rodent Plasmodium strains expressing fluorescent proteins in all life cycle stages has had a big impact on malaria research. With this tool in hand, for the first time it was possible to follow in real time by in vivo microscopy the infection route of Plasmodium sporozoites transmitted to the mammalian host by Anopheles mosquitoes. Recently, this work has been extended to the analysis of both hepatocyte infection by Plasmodium sporozoites, as well as liver merozoite transport into blood vessels. The stunning results of these studies have considerably changed our understanding of hepatocyte invasion and parasite liberation. Here, we describe the most important findings of the last years and in addition, we elaborate on the molecular events during the intracellular development of Plasmodium exoerythrocytic forms that give rise to erythrocyte infecting merozoites.

Item Type:

Journal Article (Original Article)

Division/Institute:

08 Faculty of Science > Department of Biology > Institute of Cell Biology > Malaria
08 Faculty of Science > Department of Biology > Institute of Cell Biology

UniBE Contributor:

Heussler, Volker

Subjects:

500 Science > 570 Life sciences; biology

ISSN:

0300-8584

Publisher:

Springer

Language:

English

Submitter:

Volker Heussler

Date Deposited:

06 Jul 2016 11:43

Last Modified:

07 Jul 2016 04:34

Publisher DOI:

10.1007/s00430-007-0044-3

PubMed ID:

17410380

BORIS DOI:

10.7892/boris.84079

URI:

https://boris.unibe.ch/id/eprint/84079

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