Plasmodium pre-erythrocytic stages: what's new?

Ménard, Robert; Heussler, Volker; Yuda, Masao; Nussenzweig, Victor (2008). Plasmodium pre-erythrocytic stages: what's new? Trends in parasitology, 24(12), pp. 564-569. Elsevier Current Trends 10.1016/j.pt.2008.08.009

[img] Text
1-s2.0-S1471492208002286-main.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (149kB) | Request a copy

The pre-erythrocytic (PE) phase of malaria infection, which extends from injection of sporozoites into the skin to the release of the first generation of merozoites, has traditionally been the 'black box' of the Plasmodium life cycle. However, since the advent of parasite transfection technology 13 years ago, our understanding of the PE phase in cellular and molecular terms has dramatically improved. Here, we review and comment on the major developments in the field in the past five years. Progress has been made in many diverse areas, including identifying and characterizing new proteins of interest, imaging parasites in vivo, understanding better the cell biology of hepatocyte infection and developing new vaccines against PE stages of the parasite.

Item Type:

Journal Article (Original Article)

Division/Institute:

08 Faculty of Science > Department of Biology > Institute of Cell Biology > Malaria
08 Faculty of Science > Department of Biology > Institute of Cell Biology

UniBE Contributor:

Heussler, Volker

Subjects:

500 Science > 570 Life sciences; biology

ISSN:

1471-4922

Publisher:

Elsevier Current Trends

Language:

English

Submitter:

Volker Heussler

Date Deposited:

12 Jul 2016 08:15

Last Modified:

13 Jul 2016 05:05

Publisher DOI:

10.1016/j.pt.2008.08.009

PubMed ID:

18929511

BORIS DOI:

10.7892/boris.84083

URI:

https://boris.unibe.ch/id/eprint/84083

Actions (login required)

Edit item Edit item
Provide Feedback