Grossi, Paolo; Mohacsi, Paul; Szabolcs, Zoltán; Potena, Luciano (2016). Cytomegalovirus Immunoglobulin After Thoracic Transplantation: An Overview. Transplantation, 100(3S), S1-S4. Lippincott Williams & Wilkins 10.1097/TP.0000000000001094
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OA-108, Grossi_Cytomegalovirus Immunoblobulin....pdf - Published Version Available under License Creative Commons: Attribution-Noncommercial-No Derivative Works (CC-BY-NC-ND). Download (282kB) | Preview |
Cytomegalovirus (CMV) is a highly complex pathogen which, despite modern prophylactic regimens, continues to affect a high proportion of thoracic organ transplant recipients. The symptomatic manifestations of CMV infection are compounded by adverse indirect effects induced by the multiple immunomodulatory actions of CMV. These include a higher risk of acute rejection, cardiac allograft vasculopathy after heart transplantation, and potentially bronchiolitis obliterans syndrome in lung transplant recipients, with a greater propensity for opportunistic secondary infections. Prophylaxis for CMV using antiviral agents (typically oral valganciclovir or intravenous ganciclovir) is now almost universal, at least in high-risk transplants (D+/R-). Even with extended prophylactic regimens, however, challenges remain. The CMV events can still occur despite antiviral prophylaxis, including late-onset infection or recurrent disease, and patients with ganciclovir-resistant CMV infection or who are intolerant to antiviral therapy require alternative strategies. The CMV immunoglobulin (CMVIG) and antiviral agents have complementary modes of action. High-titer CMVIG preparations provide passive CMV-specific immunity but also exert complex immunomodulatory properties which augment the antiviral effect of antiviral agents and offer the potential to suppress the indirect effects of CMV infection. This supplement discusses the available data concerning the immunological and clinical effects of CMVIG after heart or lung transplantation
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology |
UniBE Contributor: |
Mohacsi, Paul |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
0041-1337 |
Publisher: |
Lippincott Williams & Wilkins |
Language: |
English |
Submitter: |
Alessandra Witsch |
Date Deposited: |
26 Jul 2016 11:50 |
Last Modified: |
05 Dec 2022 14:57 |
Publisher DOI: |
10.1097/TP.0000000000001094 |
PubMed ID: |
26900989 |
BORIS DOI: |
10.7892/boris.84093 |
URI: |
https://boris.unibe.ch/id/eprint/84093 |
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