Evidence of cardiac injury and arrhythmias in dogs with acute kidney injury

Keller, Silvan Peter; Kovacevic, Alan; Howard, Judith; Schweighauser, Ariane; Francey, Thierry (2016). Evidence of cardiac injury and arrhythmias in dogs with acute kidney injury. Journal of small animal practice, 57(8), pp. 402-408. Pergamon Press 10.1111/jsap.12495

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OBJECTIVES Cardiac involvement in the course of acute kidney injury is described in humans as cardiorenal syndrome type 3 but has received only limited attention in dogs. This study was designed to evaluate cardiac injury and dysfunction in acute kidney injury in dogs and its association with outcome. METHODS This prospective cohort study enrolled 24 client-owned dogs with acute kidney injury. Cardiac disorders were evaluated with thoracic radiographs, echocardiography, 24-hour Holter monitoring and cardiac troponin I concentrations within 2 days of admission and 7 to 10 days later. RESULTS Most dogs were diagnosed with leptospirosis (n=18, 75%) and presented with moderate-to-severe acute kidney injury, International Renal Interest Society grades III to V. Dogs with ê100 ventricular premature complexes per 24 hour in the first examination (n=8) had significantly higher initial cTnI concentrations (P=0·007) compared to dogs with fewer than 100. In receiver operating characteristic curve analysis, the number of ventricular premature complexes was predictive of outcome (AUC 0·83, P<0·001). CLINICAL SIGNIFICANCE Acute kidney injury seems to be associated with cardiac injury and arrhythmias in dogs. The data do not indicate a cardiac cause of poor outcome in dogs with increased number of ventricular premature complexes but the association may reflect the severity of disease.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Research Foci > Host-Pathogen Interaction
05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV)
05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > Small Animal Clinic > Small Animal Clinic, Internal Medicine
05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > DKV - Central Clinical Laboratory

UniBE Contributor:

Keller, Silvan Peter; Kovacevic, Alan; Howard, Judith; Schweighauser, Ariane and Francey, Thierry

Subjects:

600 Technology > 610 Medicine & health
600 Technology > 630 Agriculture

ISSN:

0022-4510

Publisher:

Pergamon Press

Language:

English

Submitter:

Thierry Francey-Spicher

Date Deposited:

26 Jul 2016 16:09

Last Modified:

12 Aug 2016 05:32

Publisher DOI:

10.1111/jsap.12495

PubMed ID:

27357259

Uncontrolled Keywords:

Holter monitoring; acute kidney injury; arrhythmia; cardiac troponin I; echocardiography; leptospirosis

BORIS DOI:

10.7892/boris.84142

URI:

https://boris.unibe.ch/id/eprint/84142

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