Dorsal rather than ventral visual pathways discriminate freezing status in Parkinson's disease

Lord, Sue; Archibald, Neil; Mosimann, Urs; Burn, David; Rochester, Lynn (2012). Dorsal rather than ventral visual pathways discriminate freezing status in Parkinson's disease. Parkinsonism & related disorders, 18(10), pp. 1094-6. Oxford: Elsevier 10.1016/j.parkreldis.2012.05.016

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BACKGROUND: Although visuospatial deficits have been linked with freezing of gait (FOG) in Parkinson's disease (PD), the specific effects of dorsal and ventral visual pathway dysfunction on FOG is not well understood. METHOD: We assessed visuospatial function in FOG using an angle discrimination test (dorsal visual pathway bias) and overlapping figure test (ventral visual pathway bias), and recorded overall response time, mean fixation duration and dwell time. Covariate analysis was conducted controlling for disease duration, motor severity, contrast sensitivity and attention with Bonferroni adjustments for multiple comparisons. RESULTS: Twenty seven people with FOG, 27 people without FOG and 24 controls were assessed. Average fixation duration during angle discrimination distinguished freezing status: [F (1, 43) = 4.77 p < 0.05] (1-way ANCOVA). CONCLUSION: Results indicate a preferential dysfunction of dorsal occipito-parietal pathways in FOG, independent of disease severity, attentional deficit, and contrast sensitivity.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > University Psychiatric Services > University Hospital of Geriatric Psychiatry and Psychotherapy

UniBE Contributor:

Mosimann, Urs Peter

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1353-8020

Publisher:

Elsevier

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:24

Last Modified:

10 Aug 2015 13:22

Publisher DOI:

10.1016/j.parkreldis.2012.05.016

PubMed ID:

22705127

Web of Science ID:

000313399400008

BORIS DOI:

10.7892/boris.8418

URI:

https://boris.unibe.ch/id/eprint/8418 (FactScience: 213954)

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