Bipolar disorder susceptibility region on chromosome 3q29 not confirmed in a case-control association study

Schosser, Alexandra; Schloegelhofer, Monika; Fuchs, Karoline; Stojanovic, Mirjana; Mossaheb, Nilufar; Kindler, Jochen; Cohen-Woods, Sarah; Hosang, Georgina; Farmer, Anne; Craig, Ian; McGuffin, Peter; Aschauer, Harald (2011). Bipolar disorder susceptibility region on chromosome 3q29 not confirmed in a case-control association study. World journal of biological psychiatry, 12(4), pp. 309-15. London: Informa Healthcare 10.3109/15622975.2010.551407

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We identified a bipolar disorder (BPD) susceptibility region on chromosome 3q29 in a genome-wide linkage scan (Bailer et al. 2002 (Biol Psychiatry 52: 40), NPL-score 4.09) and follow-up linkage analysis (Schosser et al. 2004 (J Psychiatr Res 38(3): 357), NPL-scores >3 with five markers). These findings were supported by further fine-mapping of this region (Schosser et al. 2007 (Eur Neuropsychopharmacol 17(6-7): 501)), finding NPL-scores >3.9 with SNPs (single nucleotide polymorphisms) spanning a region of 3.46 Mbp in BPD families. Since genetic association studies are more powerful than linkage studies for detecting susceptibility genes of small effect size, we aimed to replicate these findings in an independent case-control sample collected in London (UK) and Vienna (Austria).

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Management

UniBE Contributor:

Kindler, Jochen

ISSN:

1562-2975

Publisher:

Informa Healthcare

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:24

Last Modified:

17 Mar 2015 21:04

Publisher DOI:

10.3109/15622975.2010.551407

PubMed ID:

21323636

Web of Science ID:

000290405200009

URI:

https://boris.unibe.ch/id/eprint/8433 (FactScience: 213974)

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