Post-H1N1 Flu Vaccination Narcolepsy in Switzerland: A Retrospective Survey in the 30 Sleep-Certified Swiss Centers

Kallweit, Ulf; Mathis, Johannes; Jenni, Oskar G; Heinzer, Raphaël; Haba-Rubio, José; Baumann, Christian R; Cervena, Katerina; Bassetti, Claudio (2016). Post-H1N1 Flu Vaccination Narcolepsy in Switzerland: A Retrospective Survey in the 30 Sleep-Certified Swiss Centers. European neurology, 75(3-4), pp. 105-108. Karger 10.1159/000444318

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Narcolepsy-cataplexy is a sleep-wake disorder and suggested to be immune-mediated, involving genetic and environmental factors. The autoimmune process eventually leads to a loss of hypocretin neurons in the lateral hypothalamus. Epidemiological studies in several countries proved an increased incidence of narcolepsy after H1N1 flu vaccination and infection. This survey in 30 sleep centers in Switzerland led to the identification of 9 H1N1-vaccinated children and adults as newly diagnosed narcolepsy. Clinical features included the abrupt and severe onset of sleepiness, cataplexy and sleep fragmentation.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology

UniBE Contributor:

Kallweit, Ulf; Mathis, Johannes and Bassetti, Claudio

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0014-3022

Publisher:

Karger

Language:

English

Submitter:

Stefanie Hetzenecker

Date Deposited:

28 Jul 2016 11:54

Last Modified:

24 Feb 2017 02:30

Publisher DOI:

10.1159/000444318

PubMed ID:

26901055

BORIS DOI:

10.7892/boris.84377

URI:

https://boris.unibe.ch/id/eprint/84377

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