Sleep-disordered breathing among acute ischemic stroke patients in Brazil.

Camilo, Millene R; Schnitman, Saul V; Sander, Heidi H; Eckeli, Alan L; Fernandes, Regina M F; Leite, Joao P; Bassetti, Claudio; Pontes-Neto, Octavio M (2016). Sleep-disordered breathing among acute ischemic stroke patients in Brazil. Sleep medicine, 19, pp. 8-12. Elsevier 10.1016/j.sleep.2015.11.008

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OBJECTIVES Sleep-disordered breathing (SDB) is very common in acute stroke patients and has been related to poor outcome. However, there is a lack of data about the association between SDB and stroke in developing countries. The study aims to characterize the frequency and severity of SDB in Brazilian patients during the acute phase of ischemic stroke; to identify clinical and laboratorial data related to SDB in those patients; and to assess the relationship between sleep apnea and functional outcome after six months of stroke. METHODS Clinical data and laboratorial tests were collected at hospital admission. The polysomnography was performed on the first night after stroke symptoms onset. Functional outcome was assessed by the modified Rankin Scale (mRS). RESULTS We prospectively evaluated 69 patients with their first-ever acute ischemic stroke. The mean apnea-hypopnea index (AHI) was 37.7 ± 30.2. Fifty-three patients (76.8%) exhibited an AHI ≥ 10 with predominantly obstructive respiratory events (90.6%), and thirty-three (47.8%) had severe sleep apnea. Age (OR: 1.09; 95% CI: 1.03-1.15; p= 0.004) and hematocrit (OR: 1.18; 95% CI: 1.03-1.34; p= 0.01) were independent predictors of sleep apnea. Age (OR: 1.13; 95% CI: 1.03-1.24; p= 0.01), body mass index (OR: 1.54; 95% CI: 1.54-2.18; p= 0.01), and hematocrit (OR: 1.19; 95% CI: 1.01-1.40; p= 0.04) were independent predictors of severe sleep apnea. The National Institutes of Health Stroke Scale (NIHSS; OR: 1.30; 95% CI: 1.1-1.5; p= 0.001) and severe sleep apnea (OR: 9.7; 95% CI: 1.3-73.8; p= 0.03) were independently associated to mRS >2 at six months, after adjusting for confounders. CONCLUSION Patients with acute ischemic stroke in Brazil have a high frequency of SDB. Severe sleep apnea is associated with a poor long-term functional outcome following stroke in that population.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology

UniBE Contributor:

Bassetti, Claudio

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1389-9457

Publisher:

Elsevier

Language:

English

Submitter:

Stefanie Hetzenecker

Date Deposited:

28 Jul 2016 16:36

Last Modified:

28 Jul 2016 16:36

Publisher DOI:

10.1016/j.sleep.2015.11.008

PubMed ID:

27198940

Uncontrolled Keywords:

Acute cerebral infarction; Functional outcome; Sleep; Sleep apnea; Sleep-disordered breathing; Stroke

BORIS DOI:

10.7892/boris.84381

URI:

https://boris.unibe.ch/id/eprint/84381

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