Cerebral white matter structure is associated with DSM-5 schizophrenia symptom dimensions.

Viher, Petra; Stegmayer, Katharina; Giezendanner, Stéphanie; Federspiel, Andrea; Bohlhalter, Stephan; Vanbellingen, Tim; Wiest, Roland; Strik, Werner; Walther, Sebastian (2016). Cerebral white matter structure is associated with DSM-5 schizophrenia symptom dimensions. NeuroImage: Clinical, 12, pp. 93-99. Elsevier 10.1016/j.nicl.2016.06.013

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Diffusion tensor imaging (DTI) studies have provided evidence of widespread white matter (WM) abnormalities in schizophrenia. Although these abnormalities appear clinically significant, the relationship to specific clinical symptoms is limited and heterogeneous. This study examined the association between WM microstructure and the severity of the five main DSM-5 schizophrenia symptom dimensions. DTI was measured in forty patients with schizophrenia spectrum disorders. Using Tract-Based Spatial Statistics controlling for age, gender and antipsychotic dosage, our analyses revealed significant negative relationships between WM microstructure and two DSM-5 symptom dimensions: Whereas abnormal psychomotor behavior was particularly related to WM of motor tracts, negative symptoms were associated with WM microstructure of the prefrontal and right temporal lobes. However, we found no associations between WM microstructure and delusions, hallucinations or disorganized speech. These data highlight the relevance of characteristic WM disconnectivity patterns as markers for negative symptoms and abnormal psychomotor behavior in schizophrenia and provide evidence for relevant associations between brain structure and aberrant behavior.

Item Type:

Journal Article (Original Article)

Division/Institute:

10 Strategic Research Centers > ARTORG Center for Biomedical Engineering Research > ARTORG Center - Gerontechnology and Rehabilitation
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology
04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Translational Research Center
04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Management
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic and Interventional Neuroradiology
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DCR Unit Sahli Building > Forschungsgruppe Neurologie

Graduate School:

Graduate School for Health Sciences (GHS)

UniBE Contributor:

Viher, Petra; Stegmayer, Katharina; Giezendanner, Stéphanie; Federspiel, Andrea; Bohlhalter, Stephan; Vanbellingen, Tim; Wiest, Roland; Strik, Werner and Walther, Sebastian

Subjects:

600 Technology > 610 Medicine & health
500 Science > 570 Life sciences; biology

ISSN:

2213-1582

Publisher:

Elsevier

Language:

English

Submitter:

Sebastian Walther

Date Deposited:

09 Aug 2016 15:50

Last Modified:

26 Jun 2017 13:55

Publisher DOI:

10.1016/j.nicl.2016.06.013

PubMed ID:

27408794

Uncontrolled Keywords:

Diffusion tensor imaging; Motor abnormalities; Negative syndrome; Neurobiological correlates; Tract-Based Spatial Statistics

BORIS DOI:

10.7892/boris.85586

URI:

https://boris.unibe.ch/id/eprint/85586

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