Vertical transmission of hepatitis C: towards universal antenatal screening in the era of new direct acting antivirals (DAAs)? Short review and analysis of the situation in Switzerland

Aebi-Popp, Karoline; Duppenthaler, Andrea; Rauch, Andri; De Gottardi, Andrea; Kahlert, Christian (2016). Vertical transmission of hepatitis C: towards universal antenatal screening in the era of new direct acting antivirals (DAAs)? Short review and analysis of the situation in Switzerland. Journal of virus eradication, 2(1), pp. 52-54. Mediscript

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At present, routine antenatal hepatitis C virus (HCV) screening is not recommended in pregnant women who do not have known risk factors for infection. The main reason for this attitude has been the lack of effective treatment options to avoid mother-to-child transmission (MTCT) during pregnancy or delivery. Hitherto available treatment regimens based on interferon (IFN) and ribavirin (RBV) were associated with sometimes long-lasting and severe side-effects and thus their indication had to be carefully evaluated. In addition, ribavirin has teratogenic and embryocidal effects and is absolutely contraindicated during pregnancy. The situation has substantially changed with the advent of the newly available treatment regimens based on very effective and well-tolerated direct-acting antiviral agents (DAAs). The aim of this viewpoint is to briefly analyse, using the example of Switzerland, how recent developments in HCV therapy might impact prevention of HCV vertical transmission.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Hepatology
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Infectiology
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine

UniBE Contributor:

Aebi-Popp, Karoline; Duppenthaler, Andrea; Rauch, Andri and De Gottardi, Andrea

Subjects:

600 Technology > 610 Medicine & health

ISSN:

2055-6640

Publisher:

Mediscript

Language:

English

Submitter:

Annelies Luginbühl

Date Deposited:

05 Sep 2016 14:26

Last Modified:

22 Sep 2017 13:26

PubMed ID:

27482435

Uncontrolled Keywords:

HCV; direct-acting antivirals; prevention of MTCT

BORIS DOI:

10.7892/boris.85649

URI:

https://boris.unibe.ch/id/eprint/85649

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