A novel component of the mitochondrial genome segregation machinery in trypanosomes

Hoffmann, Anneliese; Jakob, Martin; Ochsenreiter, Torsten (2016). A novel component of the mitochondrial genome segregation machinery in trypanosomes. Microbial cell, 3(8), pp. 352-354. Shared Science Publishers OG 10.15698/mic2016.08.519

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We recently described a new component (TAC102) of the mitochondrial genome segregation machinery (mtGSM) in the protozoan parasite Trypanosoma brucei. T. brucei belongs to a group of organisms that contain a single mitochondrial organelle with a single mitochondrial genome (mt-genome) per cell. The mt- genome consists of 5000 minicircles (1 kb) and 25 maxicircles (23 kb) that are catenated into a large network. After replication of the network its segrega- tion is driven by the separating basal bodies, which are homologous structures to the centrioles organiz- ing the spindle apparatus in many eukaryotes. The structure connecting the basal body to the mt- genome was named the Tripartite Attachment Com- plex (TAC) owing its name to the distribution across three areas in the cell including the two mitochondri- al membranes.

Item Type:

Journal Article (Review Article)

Division/Institute:

08 Faculty of Science > Department of Biology > Institute of Cell Biology

Graduate School:

Graduate School for Cellular and Biomedical Sciences (GCB)

UniBE Contributor:

Hoffmann, Anneliese; Jakob, Martin and Ochsenreiter, Torsten

Subjects:

500 Science > 570 Life sciences; biology

ISSN:

2311-2638

Publisher:

Shared Science Publishers OG

Funders:

[4] Swiss National Science Foundation

Language:

English

Submitter:

Torsten Ochsenreiter

Date Deposited:

22 Aug 2016 11:19

Last Modified:

20 Mar 2017 16:11

Publisher DOI:

10.15698/mic2016.08.519

BORIS DOI:

10.7892/boris.86201

URI:

https://boris.unibe.ch/id/eprint/86201

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