Structural modification of DNA--a therapeutic option in SLE?

Frese, Steffen; Diamond, Betty (2011). Structural modification of DNA--a therapeutic option in SLE? Nature reviews - rheumatology, 7(12), pp. 733-8. New York, N.Y.: Nature Publishing Group 10.1038/nrrheum.2011.153

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Systemic lupus erythematosus (SLE) is an autoimmune disease that affects multiple organs, with glomerulonephritis representing a frequent and serious manifestation. SLE is characterized by the presence of various autoantibodies, including anti-DNA antibodies that occur in approximately 70% of patients with SLE and which contribute to disease pathogenesis. Consequently, immunosuppressive therapies are applied in the treatment of SLE to reduce autoantibody levels. However, increasing evidence suggests that DNA--especially double--stranded DNA-constitutes an important pathogenic factor that is able to activate inflammatory responses by itself in autoimmune diseases. Therefore, modifying the structure of DNA to reduce its pathogenicity might be a more targeted approach for the treatment of SLE than immunosuppression. This article presents information in support of this strategy, and discusses the potential methods of DNA structure manipulation--in light of data obtained from mouse models of SLE--including topoisomerase I inhibition, administration of DNase I, or modification of histones using heparin or histone deacetylase inhibitors.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Thoracic Surgery

UniBE Contributor:

Frese, Steffen R.

ISSN:

1759-4790

Publisher:

Nature Publishing Group

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:24

Last Modified:

17 Mar 2015 21:05

Publisher DOI:

10.1038/nrrheum.2011.153

PubMed ID:

22009329

Web of Science ID:

000298147300008

URI:

https://boris.unibe.ch/id/eprint/8743 (FactScience: 214373)

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