Distinct resting-state perfusion patterns underlie psychomotor retardation in unipolar vs. bipolar depression

Cantisani, Andrea; Stegmayer, Katharina; Bracht, Tobias; Federspiel, Andrea; Wiest, Roland; Horn, Helge Joachim; Müller, Thomas; Schneider, Christoph; Höfle, Oliver Karl Christofer; Strik, Werner; Walther, Sebastian (2016). Distinct resting-state perfusion patterns underlie psychomotor retardation in unipolar vs. bipolar depression. Acta psychiatrica Scandinavica, 134(4), pp. 329-338. Wiley-Blackwell 10.1111/acps.12625

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OBJECTIVE Psychomotor abnormalities characterize both unipolar (UP) depression and bipolar (BP) depression. We aimed to assess their neurobiological correlates in terms of motor activity (AL) and resting-state cerebral blood flow (rCBF) and investigate their association in BP, UP, and healthy controls (HC). METHOD We enrolled 42 depressed patients (22 BP, 20 UP) and 19 HC matched for age, gender, education, income. AL and rCBF were objectively assessed with the use of wrist actigraphy and arterial spin labeling. Group differences and the association of AL and rCBF were computed. RESULTS Activity level was significantly reduced in patients, but no difference was found between BP and UP. Increased perfusion was found in BP compared with UP and HC, in multiple brain areas. We found positive correlations of rCBF and AL in BP and UP, in different parts of the insula and frontal regions. Only BP showed a cluster in the left precentral gyrus. In HC, only inverse correlations of AL and rCBF were found. CONCLUSION The differences in rCBF and in the localization of the clusters of positive AL/rCBF correlations between BP and UP suggest that different neural impairments may underlie motor symptoms in the two disorders, but finally converge in phenotypically similar manifestations.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Translational Research Center
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic and Interventional Neuroradiology

UniBE Contributor:

Cantisani, Andrea; Stegmayer, Katharina; Bracht, Tobias; Federspiel, Andrea; Wiest, Roland; Horn, Helge Joachim; Müller, Thomas; Schneider, Christoph; Höfle, Oliver Karl Christofer; Strik, Werner and Walther, Sebastian

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0001-690X

Publisher:

Wiley-Blackwell

Language:

English

Submitter:

Martin Zbinden

Date Deposited:

13 Sep 2016 13:51

Last Modified:

04 Jan 2017 10:47

Publisher DOI:

10.1111/acps.12625

PubMed ID:

27497085

Uncontrolled Keywords:

arterial spin labeling, bipolar disorder, cerebral blood flow, major depression, psychomotor retardation

BORIS DOI:

10.7892/boris.87518

URI:

https://boris.unibe.ch/id/eprint/87518

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