Resting in darkness improves downbeat nystagmus: evidence from an observational study.

Spiegel, Rainer; Claassen, Jens; Teufel, Julian; Bardins, Stanislav; Schneider, Erich; Lehrer Rettinger, Nicole; Jahn, Klaus; da Silva, Fábio Anciães; Hahn, Ales; Farahmand, Parvis; Brandt, Thomas; Strupp, Michael; Kalla, Roger (2016). Resting in darkness improves downbeat nystagmus: evidence from an observational study. Annals of the New York Academy of Sciences, 1375(1), pp. 66-73. Blackwell 10.1111/nyas.13172

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Resting in an upright position during daytime decreases downbeat nystagmus (DBN). When measured in brightness only, that is, without intermitting exposure to darkness, it does not make a significant difference whether patients have previously rested in brightness or in darkness. In real-world scenarios, people are often exposed to brightness and darkness intermittently. The aim of this study was to analyze whether resting in brightness or resting in darkness was associated with a lower post-resting DBN after intermitting exposures to brightness and darkness. Eight patients were recorded with three-dimensional video-oculography in brightness and darkness conditions, each following two 2-h resting intervals under either brightness or darkness resting conditions. The dependent variable was DBN intensity, measured in mean slow phase velocity. A repeated measures ANOVA with the factors measurement condition (brightness vs. darkness), resting condition (brightness vs. darkness), and time (after first vs. second resting interval) showed a significant effect for the factor resting condition, where previous resting in darkness was associated with a significantly lower DBN relative to previous resting in brightness (P < 0.01). The clinical relevance is to advise patients with DBN to rest in darkness.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology

UniBE Contributor:

Kalla, Roger

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0077-8923

Publisher:

Blackwell

Language:

English

Submitter:

Stefanie Hetzenecker

Date Deposited:

16 Sep 2016 15:20

Last Modified:

16 Sep 2016 15:20

Publisher DOI:

10.1111/nyas.13172

PubMed ID:

27447539

Uncontrolled Keywords:

downbeat nystagmus; oscillopsia; resting; symptom relief; video-oculographic measurement (VOG)

BORIS DOI:

10.7892/boris.87786

URI:

https://boris.unibe.ch/id/eprint/87786

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