Awake dynamics and brain-wide direct inputs of hypothalamic MCH and orexin networks.

González, J Antonio; Iordanidou, Panagiota; Strom, Molly; Adamantidis, Antoine Roger; Burdakov, Denis (2016). Awake dynamics and brain-wide direct inputs of hypothalamic MCH and orexin networks. Nature communications, 7(11395), p. 11395. Nature Publishing Group 10.1038/ncomms11395

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The lateral hypothalamus (LH) controls energy balance. LH melanin-concentrating-hormone (MCH) and orexin/hypocretin (OH) neurons mediate energy accumulation and expenditure, respectively. MCH cells promote memory and appropriate stimulus-reward associations; their inactivation disrupts energy-optimal behaviour and causes weight loss. However, MCH cell dynamics during wakefulness are unknown, leaving it unclear if they differentially participate in brain activity during sensory processing. By fiberoptic recordings from molecularly defined populations of LH neurons in awake freely moving mice, we show that MCH neurons generate conditional population bursts. This MCH cell activity correlates with novelty exploration, is inhibited by stress and is inversely predicted by OH cell activity. Furthermore, we obtain brain-wide maps of monosynaptic inputs to MCH and OH cells, and demonstrate optogenetically that VGAT neurons in the amygdala and bed nucleus of stria terminalis inhibit MCH cells. These data reveal cell-type-specific LH dynamics during sensory integration, and identify direct neural controllers of MCH neurons.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology

UniBE Contributor:

Adamantidis, Antoine Roger

Subjects:

600 Technology > 610 Medicine & health

ISSN:

2041-1723

Publisher:

Nature Publishing Group

Language:

English

Submitter:

Stefanie Hetzenecker

Date Deposited:

16 Sep 2016 10:26

Last Modified:

18 Sep 2016 02:08

Publisher DOI:

10.1038/ncomms11395

PubMed ID:

27102565

BORIS DOI:

10.7892/boris.87814

URI:

https://boris.unibe.ch/id/eprint/87814

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