MCH receptor deletion does not impair glucose-conditioned flavor preferences in mice.

Sclafani, Anthony; Adamantidis, Antoine Roger; Ackroff, Karen (2016). MCH receptor deletion does not impair glucose-conditioned flavor preferences in mice. Physiology & behavior, 163, pp. 239-244. Elsevier 10.1016/j.physbeh.2016.05.024

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The post-oral actions of glucose stimulate intake and condition flavor preferences in rodents. Hypothalamic melanin-concentrating hormone (MCH) neurons are implicated in sugar reward, and this study investigated their involvement in glucose preference conditioning in mice. In Exp. 1 MCH receptor 1 knockout (KO) and C57BL/6 wildtype (WT) mice learned to prefer 8% glucose over an initially more-preferred non-nutritive 0.1% sucralose+saccharin (S+S) solution. In contrast, the KO and WT mice preferred S+S to 8% fructose, which is consistent with this sugar's weak post-oral reinforcing action. In Exp. 2 KO and WT mice were trained to drink a flavored solution (CS+) paired with intragastric (IG) infusion of 16% glucose and a different flavored solution (CS-) paired with IG water. Both groups drank more CS+ than CS- in training and preferred the CS+ to CS- in a 2-bottle test. These results indicate that MCH receptor signaling is not required for flavor preferences conditioned by the post-oral actions of glucose. This contrasts with other findings implicating MCH signaling in other types of sugar reward processing.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology

UniBE Contributor:

Adamantidis, Antoine Roger

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0031-9384

Publisher:

Elsevier

Language:

English

Submitter:

Stefanie Hetzenecker

Date Deposited:

16 Sep 2016 09:55

Last Modified:

16 Sep 2016 09:55

Publisher DOI:

10.1016/j.physbeh.2016.05.024

PubMed ID:

27195455

Uncontrolled Keywords:

Flavor conditioning; Fructose; Glucose; Intragastric; Melanin-concentrating hormone; Non-nutritive sweetener

BORIS DOI:

10.7892/boris.87816

URI:

https://boris.unibe.ch/id/eprint/87816

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