Vagal reactivation after exercise and cardiac autonomic nervous activity in adult Fontan patients without pacemakers

Eser, Prisca; Herzig, David; Vogt, Marcel; Stämpfli, Roger; Trovato, Moreno; Olstad, Daniela Schäfer; Trachsel, Lukas; Deluigi, Christina; Wustmann, Kerstin Brigitte; Greutmann, Matthias; Tobler, Daniel; Stambach, Dominik; Schmid, Jean-Paul; Schwerzmann, Markus; Wilhelm, Matthias (2016). Vagal reactivation after exercise and cardiac autonomic nervous activity in adult Fontan patients without pacemakers. International journal of cardiology, 220, pp. 527-533. Elsevier 10.1016/j.ijcard.2016.06.274

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Patients with Fontan circulation have reduced heart rate variability (HRV) in supine position. However, neither cardiac autonomic nervous activity (CANA) in response to orthostatic challenge nor vagal reactivation by means of heart rate (HR) recovery after cessation of exercise have previously been investigated in Fontan patients. The aim of this study was to compare HRV in supine and standing position, as well as HR recovery between Fontan patients and healthy controls.


Eight Fontan patients (4 male/4 female) without pacemakers and 12 healthy volunteers (5m/7f) with minimum age of 18years were recruited. HR was measured by Holter-electrocardiogram. HRV was measured in supine position and after orthostatic challenge. The power of the high frequency (HF: 0.15Hz-0.4Hz) and low frequency (LF: 0.04Hz-0.15Hz) bands was analysed by fast-Fourier transformation. HR recovery was determined at 30s and 60s after termination of a maximal exercise test.


In both supine and standing position, total power, HF and LF power were reduced in Fontan patients compared to controls (by approximately a factor of 10) while there was no differences in LF/HF power ratio. Response to orthostatic challenge was blunted in absolute power but normal in relative power. HR recovery was not different between groups.


Fontan patients have greatly reduced HRV, a blood-pressure dependent marker of CANA, but normal HR recovery, a blood pressure independent marker of vagal reactivation, suggesting that vagal activity may be normal, and only vascular capacitance reduced.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology

UniBE Contributor:

Eser, Prisca Christina, Herzig, David, Trachsel, Lukas, Deluigi, Christina, Wustmann, Kerstin Brigitte, Schmid-Walker, Jean-Paul, Schwerzmann, Markus, Wilhelm, Matthias


600 Technology > 610 Medicine & health








Markus Schwerzmann

Date Deposited:

21 Sep 2016 10:36

Last Modified:

02 Mar 2023 23:28

Publisher DOI:


PubMed ID:


Uncontrolled Keywords:

Cardiac autonomic nervous system; Fontan patients; Grown-ups with congenital heart disease; Heart rate recovery; Heart rate variability; Orthostatic challenge




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