Campos, Miguel; Ducatelle, R; Kooistra, H S; Rutteman, G; Duchateau, L; Polis, I; Daminet, S (2014). Immunohistochemical expression of potential therapeutic targets in canine thyroid carcinoma. Journal of veterinary internal medicine, 28(2), pp. 564-570. Wiley-Blackwell 10.1111/jvim.12330
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BACKGROUND
Thyroid carcinoma is a common endocrine tumor in the dog. Local invasive growth frequently precludes surgical excision and, in up to 38% of dogs, the tumor has already metastasized by the time of diagnosis. Therefore, it is important to investigate new treatment modalities that may be useful for the large number of dogs with inoperable tumors or metastatic disease.
HYPOTHESIS/OBJECTIVES
To investigate the immunohistochemical expression of potential therapeutic targets in canine thyroid tumors.
ANIMALS
74 dogs with thyroid neoplasia.
METHODS
Immunohistochemistry was performed for thyroglobulin, calcitonin, vascular endothelial growth factor (VEGF), p53, cycloxygenase-2 (cox-2), and P-glycoprotein (P-gp).
RESULTS
Fifty-four (73%) tumors were classified as follicular cell thyroid carcinomas (FTCs) and 20 (27%) as medullary thyroid carcinomas (MTCs). Eighty percent of FTCs and all MTCs had a high percentage (76-100%) of neoplastic cells immunopositive for VEGF. Thirteen percent of FTCs and 50% of MTCs expressed cox-2. Seven percent of FTCs and 70% of MTCs expressed P-gp. No tumor was immunopositive for p53 expression. Expression of VEGF (P = .034), cox-2 (P = .013), and P-gp (P < .001) was significantly higher in MTCs compared to FTCs.
CONCLUSIONS AND CLINICAL IMPORTANCE
VEGF is a potential therapeutic target in both FTC and MTC in dogs. Cox-2 and P-gp may be useful molecular targets in canine MTC.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) |
UniBE Contributor: |
Campos, Miguel |
Subjects: |
600 Technology > 630 Agriculture |
ISSN: |
0891-6640 |
Publisher: |
Wiley-Blackwell |
Language: |
English |
Submitter: |
Miguel Fonseca e Campos |
Date Deposited: |
23 Sep 2016 11:14 |
Last Modified: |
05 Dec 2022 14:58 |
Publisher DOI: |
10.1111/jvim.12330 |
PubMed ID: |
24612088 |
Uncontrolled Keywords: |
Cyclooxygenase-2; P-glycoprotein; VEGF; p53 |
BORIS DOI: |
10.7892/boris.88130 |
URI: |
https://boris.unibe.ch/id/eprint/88130 |
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