Quantitative multiparameter assays to measure the effect of adjuvants on human antigen-specific CD8 T-cell responses

Derré, Laurent; Jandus, Camilla; Baumgaertner, Petra; Posevitz, Vilmos; Devêvre, Estelle; Romero, Pedro; Speiser, Daniel E (2010). Quantitative multiparameter assays to measure the effect of adjuvants on human antigen-specific CD8 T-cell responses. Methods in molecular biology, 626, pp. 231-249. Totowa, N.J.: Humana Press 10.1007/978-1-60761-585-9_16

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Large numbers and functionally competent T cells are required to protect from diseases for which antibody-based vaccines have consistently failed (1), which is the case for many chronic viral infections and solid tumors. Therefore, therapeutic vaccines aim at the induction of strong antigen-specific T-cell responses. Novel adjuvants have considerably improved the capacity of synthetic vaccines to activate T cells, but more research is necessary to identify optimal compositions of potent vaccine formulations. Consequently, there is a great need to develop accurate methods for the efficient identification of antigen-specific T cells and the assessment of their functional characteristics directly ex vivo. In this regard, hundreds of clinical vaccination trials have been implemented during the last 15 years, and monitoring techniques become more and more standardized.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Pharmacology

UniBE Contributor:

Jandus, Camilla

ISSN:

1064-3745

Publisher:

Humana Press

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:09

Last Modified:

26 Feb 2016 14:42

Publisher DOI:

10.1007/978-1-60761-585-9_16

PubMed ID:

20099132

URI:

https://boris.unibe.ch/id/eprint/887 (FactScience: 201179)

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