The dynamics of spatio-temporal Rho GTPase signaling: formation of signaling patterns.

Fritz, Rafael Dominik; Pertz, Olivier (2016). The dynamics of spatio-temporal Rho GTPase signaling: formation of signaling patterns. F1000Research, 5(749) F1000 Research Ltd 10.12688/f1000research.7370.1

[img]
Preview
Text
98b9987b-b41b-4bf1-843b-651d00bfde42_7370_-_olivier_pertz.pdf - Published Version
Available under License Creative Commons: Attribution (CC-BY).

Download (1MB) | Preview

Rho GTPases are crucial signaling molecules that regulate a plethora of biological functions. Traditional biochemical, cell biological, and genetic approaches have founded the basis of Rho GTPase biology. The development of biosensors then allowed measuring Rho GTPase activity with unprecedented spatio-temporal resolution. This revealed that Rho GTPase activity fluctuates on time and length scales of tens of seconds and micrometers, respectively. In this review, we describe Rho GTPase activity patterns observed in different cell systems. We then discuss the growing body of evidence that upstream regulators such as guanine nucleotide exchange factors and GTPase-activating proteins shape these patterns by precisely controlling the spatio-temporal flux of Rho GTPase activity. Finally, we comment on additional mechanisms that might feed into the regulation of these signaling patterns and on novel technologies required to dissect this spatio-temporal complexity.

Item Type:

Journal Article (Original Article)

Division/Institute:

08 Faculty of Science > Department of Biology > Institute of Cell Biology

UniBE Contributor:

Pertz, Olivier

Subjects:

500 Science > 570 Life sciences; biology

ISSN:

2046-1402

Publisher:

F1000 Research Ltd

Language:

English

Submitter:

Olivier Pertz

Date Deposited:

30 Sep 2016 11:17

Last Modified:

30 Sep 2016 11:26

Publisher DOI:

10.12688/f1000research.7370.1

PubMed ID:

27158467

Uncontrolled Keywords:

GTPase-activating proteins; Guanine nucleotide exchange factors; Rho GTPase; signalling patterns; spatio-temporal control

BORIS DOI:

10.7892/boris.88878

URI:

https://boris.unibe.ch/id/eprint/88878

Actions (login required)

Edit item Edit item
Provide Feedback