Deep brain stimulation and sleep-wake functions in Parkinson's disease: A systematic review.

Eugster, Lukas; Bargiotas, Panagiotis; Bassetti, Claudio; Schüpbach, Michael (2016). Deep brain stimulation and sleep-wake functions in Parkinson's disease: A systematic review. Parkinsonism & related disorders, 32, pp. 12-19. Elsevier 10.1016/j.parkreldis.2016.08.006

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Sleep-wake disturbances (SWD) are common nonmotor symptoms (NMS) and have a great impact on quality of life of patients with Parkinson's disease (PD). Deep brain stimulation (DBS) is an established treatment in PD. While the beneficial effects of DBS on cardinal PD motor symptoms are indisputable, the data for several NMS, including sleep-wake functions, are limited and often controversial. Our primary objective was to review the literature on the impact of DBS on sleep-wake functions in patients with PD. A systematic review of articles, published in PubMed between January 1st, 2000 and December 31st, 2015 was performed to identify studies addressing the evolution of sleep-wake functions after DBS in patients with PD. Only 38 of 208 studies, involving a total of 1443 subjects, met the inclusion criteria. Most of them reported a positive effect of subthalamic DBS on sleep quality and consequently on quality of life. Seven studies used polysomnography to objectively assess sleep parameters. The data concerning subthalamic DBS and wake functions are controversial and studies using objective, laboratory-based measures for the assessment of wake functions are lacking. Very few studies assessed the impact of other DBS targets (e.g. pallidal stimulation) on SWD. Further prospective observational DBS studies assessing subjectively and objectively specific sleep-wake parameters in patients with PD are needed.

Item Type:

Journal Article (Review Article)


04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DCR Unit Sahli Building > Forschungsgruppe Neurologie
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology

UniBE Contributor:

Bargiotas, Panagiotis; Bassetti, Claudio and Schüpbach, Michael


600 Technology > 610 Medicine & health








Stefanie Hetzenecker

Date Deposited:

04 Oct 2016 09:05

Last Modified:

23 Sep 2017 10:49

Publisher DOI:


PubMed ID:


Uncontrolled Keywords:

Deep brain stimulation; Globus pallidus internus (GPi); Nonmotor symptoms; Nucleus subthalamicus (STN); Parkinson's disease; Sleep; Wakefulness




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