Pharmacokinetic and Pharmacodynamic Characteristics of Subcutaneously Applied PTH-1-37.

Forssmann, Wolf-Georg; Tillmann, Hanns-Christian; Hock, Dieter; Forssmann, Kristin; Bernasconi, Corrado Angelo; Forssmann, Ulf; Richter, Rudolf; Hocher, Berthold; Pfützner, Andreas (2016). Pharmacokinetic and Pharmacodynamic Characteristics of Subcutaneously Applied PTH-1-37. Kidney & blood pressure research, 41(5), pp. 507-518. Karger 10.1159/000443453

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BACKGROUND/AIMS Parathyroid hormone (PTH) derivatives exert pronounced renal and osteoanabolic properties when given intermittently. The current study was performed to assess the pharmacokinetic and pharmacodynamic properties as well as safety of subcutaneously applied PTH-1-37 after repeated dosing in healthy subjects. METHODS This randomized, double-blind, dose-escalating, placebo and active comparator controlled study was conducted in 33 healthy postmenopausal women. Subjects were allocated to one of five treatment options: 10, 20, or 40 µg PTH-1-37, 20 µg PTH-1-34 or placebo, administered as once daily subcutaneous doses for three days. Plasma drug concentrations and serum levels of endogenous PTH-1-84, and calcium as markers of biological activity were monitored during the treatment. RESULTS PTH was absorbed rapidly from the subcutaneous tissue with a median tmax of 30 minutes for 20 and 40 µg of PTH-1-37. tmax was 45 minutes for 20 µg PTH-1-34. Elimination half-lives were estimated as 76 ± 34 min and 70 ± 13 min for 20 µg and 40 µg PTH-1-37 (mean ± SD), and 78 ± 34 for 20 µg PTH-1-34. Both PTH fragments (PTH-1-37 and PTH-1-34) increased serum calcium. For PTH-1-37 the effect on serum calcium was dose-dependent. Suppression of endogenous PTH-1-84 was seen after the application of both PTH-1-37 and PTH-1-34. During the study period, the subjects experienced no unexpected or serious adverse events. CONCLUSIONS PTH-1-37 is rapidly absorbed after s.c. injection, has a short plasma elimination half-life, and does not accumulate during multiple dosing. Biological activity was demonstrated by rising serum calcium and decreasing endogenous PTH-1-84 in blood plasma. The study drugs were well tolerated and safe. Our investigation presents data that PTH-1-37 is an excellent drug candidate for intervening with syndromes of dysregulation of calcium metabolism.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology

UniBE Contributor:

Bernasconi, Corrado Angelo

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1423-0143

Publisher:

Karger

Language:

English

Submitter:

Stefanie Hetzenecker

Date Deposited:

14 Nov 2016 14:25

Last Modified:

14 Nov 2016 14:25

Publisher DOI:

10.1159/000443453

PubMed ID:

27487342

BORIS DOI:

10.7892/boris.89174

URI:

https://boris.unibe.ch/id/eprint/89174

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