Measles Virus Fusion Protein: Structure, Function and Inhibition.

Plattet, Philippe; Alves, Lisa; Herren, Michael; Aguilar, Hector C (2016). Measles Virus Fusion Protein: Structure, Function and Inhibition. Viruses, 8(4), p. 112. Molecular Diversity Preservation International MDPI 10.3390/v8040112

[img]
Preview
Text
viruses-08-00112.pdf - Published Version
Available under License Creative Commons: Attribution (CC-BY).

Download (954kB) | Preview

Measles virus (MeV), a highly contagious member of the Paramyxoviridae family, causes measles in humans. The Paramyxoviridae family of negative single-stranded enveloped viruses includes several important human and animal pathogens, with MeV causing approximately 120,000 deaths annually. MeV and canine distemper virus (CDV)-mediated diseases can be prevented by vaccination. However, sub-optimal vaccine delivery continues to foster MeV outbreaks. Post-exposure prophylaxis with antivirals has been proposed as a novel strategy to complement vaccination programs by filling herd immunity gaps. Recent research has shown that membrane fusion induced by the morbillivirus glycoproteins is the first critical step for viral entry and infection, and determines cell pathology and disease outcome. Our molecular understanding of morbillivirus-associated membrane fusion has greatly progressed towards the feasibility to control this process by treating the fusion glycoprotein with inhibitory molecules. Current approaches to develop anti-membrane fusion drugs and our knowledge on drug resistance mechanisms strongly suggest that combined therapies will be a prerequisite. Thus, discovery of additional anti-fusion and/or anti-attachment protein small-molecule compounds may eventually translate into realistic therapeutic options.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Research Foci > NeuroCenter
05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) > Experimental Clinical Research
05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH)

UniBE Contributor:

Plattet, Philippe and Herren, Michael

ISSN:

1999-4915

Publisher:

Molecular Diversity Preservation International MDPI

Language:

English

Submitter:

Susanne Portner

Date Deposited:

07 Nov 2016 11:08

Last Modified:

07 Nov 2016 11:08

Publisher DOI:

10.3390/v8040112

PubMed ID:

27110811

Uncontrolled Keywords:

cell entry; fusion protein; inhibitors and mechanisms of adaptation; measles virus; membrane fusion; neuroinvasion; structural changes

BORIS DOI:

10.7892/boris.89318

URI:

https://boris.unibe.ch/id/eprint/89318

Actions (login required)

Edit item Edit item
Provide Feedback