Physicochemical investigations of homeopathic potencies: A systematic review of the literature

Klein, Sabine; Tournier, Alexander; Würtenberger, Sandra; Wolf, Ursula; Baumgartner, Stephan (9 September 2016). Physicochemical investigations of homeopathic potencies: A systematic review of the literature. European journal of integrative medicine, 8(Suppl1), p. 27. Elsevier 10.1016/j.eujim.2016.08.065

Introduction: In order to direct future research on homeopathic potencies, it is necessary to have a solid overview over previously used methods and experimental results. For this systematic review, we focussed on laboratory experiments that investigated physicochemical properties of homeopathic potencies and compared them to controls or between several potency levels. Methods: Relevant publications were searched for in databases (SCOPUS, Embase, Web of Science, HomBRex, PubMed), article references, and personal collections of literature. Eligible documents were peer-reviewed articles, theses, books, book sections, and conference proceedings without language restrictions. Biological systems and mathematical models were excluded. All articles found were rated by two reviewers according to a manuscript information score (MIS). Articles could score between 0 and 10 points, as 0 to 2 points were given each for description of: experimental procedure, materials, measuring instruments, potentisation method, controls. Articles with an average MIS ≥5 were retained for further review. Results: 173 publications were submitted to information scoring. 57 publications were excluded due to low MIS, and 116 publications with an average MIS of 7.2 were included in the review. Among the physical and chemical methods used were: nuclear magnetic resonance; spectroscopy; (thermo)luminescence; fluorescence; conductivity; calorimetry; pH; atomic force microscopy, and transmission electron microscopy. High quality research was characterised by the use of several independent production series of the potencies, adequate controls, blinding and randomisation of the samples, and statistical analyses of the results. Conclusions:Arigorous methodology is necessary to receive meaningful results in the physicochemical characterisation of homeopathic potencies.

Item Type:

Conference or Workshop Item (Abstract)


04 Faculty of Medicine > Medical Education > Institute of Complementary and Integrative Medicine (IKIM)

UniBE Contributor:

Klein, Sabine; Tournier, Alexander; Wolf, Ursula and Baumgartner, Stephan


500 Science > 530 Physics
500 Science > 540 Chemistry








Sabine Klein

Date Deposited:

08 Nov 2016 12:55

Last Modified:

08 Nov 2016 12:55

Publisher DOI:



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