Theta burst stimulation over premotor cortex in Parkinson's disease: an explorative study on manual dexterity.

Vanbellingen, Tim; Pastore-Wapp, Manuela; Stegmayer, Katharina; Bertschi, Manuel; Abela, Eugenio; Kübel, Stefanie; Nyffeler, Thomas; Müri, René Martin; Walther, Sebastian; Nef, Tobias; Hallett, Mark; Bohlhalter, Stephan (2016). Theta burst stimulation over premotor cortex in Parkinson's disease: an explorative study on manual dexterity. Journal of neural transmission, 123(12), pp. 1387-1393. Springer 10.1007/s00702-016-1614-6

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Dorsal pre-motor cortex (PMd) is thought to play a role in fine motor control. The aim of the present study was to investigate whether inhibitory or excitatory stimulation of PMd would have an impact on manual dexterity in Parkinson's disease (PD). Fifteen patients with PD participated in this study. High resolution structural MRI was used for neuro-navigated TBS. Participants were targeted with one train of TBS in three experimental sessions: sham stimulation over vertex, continuous TBS (cTBS) over PMd and intermittent TBS (iTBS) over PMd, respectively. Dexterity was measured by a coin rotation task (CRT), which is a valid measure to detect limb kinetic apraxia (LKA). Neither cTBS or iTBS significantly interfered with CRT. Post hoc sub-analysis in a group of PD patients (n = 5) with stronger baseline impairment, indicating LKA, revealed further deterioration of dexterous performance for the cTBS condition (p = 0.04). This sham controlled pilot study demonstrates that TBS over PMd does not significantly interfere with dexterity in PD. However, patients with dexterous impairment qualifying for LKA may be more susceptible to TBS.

Item Type:

Journal Article (Original Article)

Division/Institute:

10 Strategic Research Centers > ARTORG Center for Biomedical Engineering Research > ARTORG Center - Gerontechnology and Rehabilitation
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04 Faculty of Medicine > University Psychiatric Services > University Hospital of Geriatric Psychiatry and Psychotherapy
10 Strategic Research Centers > ARTORG Center for Biomedical Engineering Research
04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Translational Research Center
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic and Interventional Neuroradiology

UniBE Contributor:

Vanbellingen, Tim; Pastore-Wapp, Manuela; Stegmayer, Katharina; Bertschi, Manuel; Abela, Eugenio; Nyffeler, Thomas; Müri, René Martin; Walther, Sebastian; Nef, Tobias and Bohlhalter, Stephan

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISSN:

0300-9564

Publisher:

Springer

Language:

English

Submitter:

Martin Zbinden

Date Deposited:

08 Nov 2016 12:48

Last Modified:

26 Jun 2017 13:52

Publisher DOI:

10.1007/s00702-016-1614-6

PubMed ID:

27619658

Uncontrolled Keywords:

Coin rotation; Limb kinetic apraxia; Manual dexterity; Parkinson’s disease; Premotor cortex

BORIS DOI:

10.7892/boris.89335

URI:

https://boris.unibe.ch/id/eprint/89335

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