Post Tick-Borne Encephalitis Virus Vaccination Narcolepsy with Cataplexy.

Hidalgo, Hildegard; Kallweit, Ulf; Mathis, Johannes; Bassetti, Claudio (2016). Post Tick-Borne Encephalitis Virus Vaccination Narcolepsy with Cataplexy. Sleep, 39(10), pp. 1811-1814. American Academy of Sleep Medicine 10.5665/sleep.6160

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STUDY OBJECTIVES Narcolepsy with cataplexy (NC) is a chronic neurological disorder thought to result from an altered immune response based on a genetic predisposition coupled with environmental factors. Pandemrix vaccination has been reported to increase the risk of narcolepsy. We aimed at identifying other vaccines associated with the onset of narcolepsy. METHODS Case series and retrospective database study. RESULTS We identified four cases of NC following a tick-borne encephalitis (TBE) vaccination with FSME Immun. Additional four cases could be detected in the database of the Paul-Ehrlich-Institut, Federal Institute for Vaccines and Biomedicines in Germany. CONCLUSIONS Our findings implicate TBE vaccination as a potential additional environmental factor for the development of NC and add additional evidence for an immunological mechanism in the pathogenesis of the disease.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DCR Unit Sahli Building > Forschungsgruppe Neurologie
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology

UniBE Contributor:

Kallweit, Ulf; Mathis, Johannes and Bassetti, Claudio

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0161-8105

Publisher:

American Academy of Sleep Medicine

Language:

English

Submitter:

Stefanie Hetzenecker

Date Deposited:

27 Oct 2016 11:13

Last Modified:

27 Oct 2016 11:13

Publisher DOI:

10.5665/sleep.6160

PubMed ID:

27397572

Uncontrolled Keywords:

cataplexy; dendritic cells; granzyme; hypocretin; narcolepsy; tick-borne encephalitis virus vaccination

URI:

https://boris.unibe.ch/id/eprint/89358

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