Comparison of Clinical Outcomes After Multivessel Versus Single-Vessel Stenting With the Zotarolimus-Eluting Stent in the RESOLUTE Global Clinical Trial Program.

Manoharan, Ganesh; Belardi, Jorge A; Du, Zhimin; Lee, Michael; Qiao, Shubin; Serruys, Patrick W; Windecker, Stephan; Xu, Bo; Yeung, Alan (2016). Comparison of Clinical Outcomes After Multivessel Versus Single-Vessel Stenting With the Zotarolimus-Eluting Stent in the RESOLUTE Global Clinical Trial Program. EuroIntervention, 12(13), pp. 1605-1613. Europa Digital & Publishing 10.4244/EIJ-D-16-00079

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AIMS To investigate whether long-term (3-year) clinical outcomes after multivessel treatment with the Resolute zotarolimus-eluting stent (R-ZES) were similar to single-vessel treatment. METHODS AND RESULTS The RESOLUTE Global Clinical Trial Program enrolled 7618 patients, of whom 1562 underwent multivessel and 6053 single-vessel treatment with the R- ZES. Patients in the multivessel group were more likely to have complex lesions (58% vs 44%, p<0.001). Clinical outcomes were compared using a Cox regression model adjusted by propensity score to account for differences in baseline characteristics. Compared with single-vessel treatment, multivessel treatment was associated with more complex anatomy and longer mean total stent length (57.8±28.6 vs 26.7±15.2 mm, p<0.001). At 3 years, the cumulative incidence of target lesion failure was similar in patients with multivessel and single-vessel treatment (11.0% vs 9.1%, adjusted p=0.986), as was the incidence of cardiac death or target vessel myocardial infarction (6.7% vs 5.7%, adjusted p=0.793), the incidence of clinically driven target lesion revascularization (5.1% vs 4.4%, adjusted p=0.904), and the incidence of Academic Research Consortium definite or probable stent thrombosis (1.2% vs 0.9%, adjusted p=0.544). CONCLUSIONS Multivessel treatment with R-ZES provided excellent long-term clinical outcomes that were comparable to those achieved with single-vessel stenting, supporting the efficacy and safety of R-ZES in patients this setting.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology

UniBE Contributor:

Windecker, Stephan

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1774-024X

Publisher:

Europa Digital & Publishing

Language:

English

Submitter:

Judith Liniger

Date Deposited:

28 Nov 2016 15:46

Last Modified:

21 Jan 2017 01:30

Publisher DOI:

10.4244/EIJ-D-16-00079

PubMed ID:

27773864

URI:

https://boris.unibe.ch/id/eprint/89635

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