Development of Late-Onset Preeclampsia in Association with Road Densities as a Proxy for Traffic-Related Air Pollution.

Wu, Meng; Ries, Jean-Jacques; Proietti, Elena; Vogt, Deborah; Hahn, Sinuhe; Hoesli, Irene (2016). Development of Late-Onset Preeclampsia in Association with Road Densities as a Proxy for Traffic-Related Air Pollution. Fetal diagnosis and therapy, 39(1), pp. 21-27. Karger 10.1159/000381802

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INTRODUCTION Previous epidemiological studies indicate an association between maternal exposure to air pollution and an increased risk of hypertensive disorders in pregnancy. We analyzed the association between the occurrence of mild/severe and early-/late-onset preeclampsia (PE) and traffic-related air pollution (TRAP). MATERIALS AND METHODS Based on retrospective data, 50 pregnant women with PE were selected and matched with a control group of healthy pregnant women according to their age, parity, and number of fetuses. The total length of major roads around the women's home within a radius of 100, 200, 300, and 500 m and the distances from the domicile to the nearest 'first class' main road and freeway were used as a proxy indicator of TRAP. We compared a PE subgroup and control group in terms of their exposure to TRAP. RESULTS Late-onset PE cases showed a significantly higher occurrence with density of major roads within a radius of 100-300 m compared to early onset cases (p = 0.006; 0.02; 0.04). In addition, a significantly shorter distance to the nearest 'first class' main road was observed in late-onset PE cases (p = 0.0078). CONCLUSIONS Exposure to TRAP during pregnancy was associated with an increased risk for the development of late-onset PE.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine

Graduate School:

Graduate School for Cellular and Biomedical Sciences (GCB)

UniBE Contributor:

Proietti, Elena

Subjects:

600 Technology > 610 Medicine & health
500 Science

ISSN:

1015-3837

Publisher:

Karger

Language:

English

Submitter:

Elena Proietti

Date Deposited:

01 Nov 2016 15:37

Last Modified:

01 Nov 2016 15:37

Publisher DOI:

10.1159/000381802

PubMed ID:

26088708

BORIS DOI:

10.7892/boris.89768

URI:

https://boris.unibe.ch/id/eprint/89768

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