Impact of body composition changes on risk of all-cause mortality in older adults.

Graf, Christophe E; Herrmann, François R; Spoerri, Adrian; Makhlouf, Anne-Marie; Sørensen, Thorkild I A; Ho, Sylvain; Karsegard, Véronique L; Genton, Laurence (2016). Impact of body composition changes on risk of all-cause mortality in older adults. Clinical nutrition, 35(6), pp. 1499-505. Elsevier 10.1016/j.clnu.2016.04.003

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PURPOSE This study evaluates the relationship between body mass index (BMI), fat mass index (FMI) and fat-free mass index (FFMI) changes and mortality in persons ≥65 years. METHODS Adults ≥65 years with at least two body composition measurements (BCM) between 1990 and 2011 were included. We excluded persons who died within one month of the second BCM and who had two single BCM in a one-month timeframe. Mortality data was retrieved until December 2012. For each person, we calculated the regression slopes for BMI, FMI and FFMI changes. Significant positive slopes were categorized as "gain", negative slopes as "loss" and the others as "maintenance". The impact of body composition changes was evaluated by Cox regression models while adjusting for sex, age, co-morbidities and body composition at the last measurement. RESULTS We included 791 persons with 3049 BCM. After adjustment for sex, and age and co-morbidities, a loss of FFMI, but not of FMI or BMI, increased the risk of mortality (HR 2.02, 95%CI 1.28-3.19). The prediction of mortality with FFMI loss remained significant when further adjusting for FMI loss and the last available body composition (HR 1.68, 95%CI 1.04-2.70). CONCLUSIONS FFMI loss is related to increased mortality in older persons.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine (ISPM)

UniBE Contributor:

Spörri, Adrian


600 Technology > 610 Medicine & health
300 Social sciences, sociology & anthropology > 360 Social problems & social services








Doris Kopp Heim

Date Deposited:

03 Nov 2016 10:15

Last Modified:

24 Oct 2019 06:34

Publisher DOI:


PubMed ID:


Uncontrolled Keywords:

Body composition; Fat mass index; Fat-free mass index; Mortality




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