id,shortref,author1,authors,title,journal,volume,issue,pages,year,decade,epub,pmid,doi,endnoteid,language,url1,address,country_firstau,firstregio,country_lastau,funding,keywords,abstract,source,strategydate,incl_abstr,excl_abstr,incl_fullt,excl_fullt,infotype,peerreview,articletype,linked,primrecyn,primrecno,researchtype,studytype
1,"Dick, Trans R Soc Trop Med Hyg, 1952",Dick,"Dick, G. W., Kitchen, S. F., Haddow, A. J.",Zika virus. I. Isolations and serological specificity,Trans R Soc Trop Med Hyg,46,5,509-20,1952,1950-1959,September 1, 1952,12995440,,1495,English,,,United Kingdom,Europe,United States,Not reported/unknown,"*Flavivirus, Humans, *Sensitivity and Specificity, *Viruses",,Pubmed,March 31, 2016,Yes,,Yes,,Scientific (journal) article,Yes,Original research,No,Yes,1,Basic and applied biomedical research,Animal experiment
2,"Dick, Trans R Soc Trop Med Hyg, 1952",Dick,"Dick, G. W.",Zika virus. II. Pathogenicity and physical properties,Trans R Soc Trop Med Hyg,46,5,521-34,1952,1950-1959,September 1, 1952,12995441,,1494,English,,,United Kingdom,Europe,,Not reported/unknown,"*Flavivirus, Humans, Virulence, *Viruses",,Pubmed,March 31, 2016,Yes,,Yes,,Scientific (journal) article,Yes,Original research,No,Yes,2,Basic and applied biomedical research,Animal experiment
3,"Smithburn, Journal of Immunology, 1952",Smithburn,"Smithburn, K. C.",Neutralizing antibodies against certain recently isolated viruses in the sera of human beings residing in East Africa,Journal of Immunology,69,2,223-234,1952,1950-1959,,7534597,,1808,English,http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emcl1&AN=0007534597,"(Smithburn) Rockefeller Found., Div. of Med. and Publ. Hlth., New York, NY, United States, K.C. Smithburn, Rockefeller Found., Div. of Med. and Publ. Hlth., New York, NY, United States",United States,Americas,,Not reported/unknown,"Africa, blood, Bunyamwera virus, fever, human, immunity, infection, Mengo virus, semliki forest alphavirus, serum, Tanzania, Uganda, virus, neutralizing antibody","Nearly 300 blood specimens collected from residents of Uganda and Tanganyika were tested against 8 viruses isolated in East Africa in order to determine the frequency with which these agents attack man. The results indicate that infection with Bwamba fever virus occurs in all the districts surveyed and in some of them the incidence is high. The results with Ntaya, Zika, and Uganda S viruses indicate that they also attack human beings rather commonly. The incidence of immunity to West Nile and Semliki Forest viruses was lower than in other areas sampled previously. 3% of sera neutralized Bunyamwera virus, but immunity to Mengo virus was found so rarely as to indicate that infection with this agent is uncommon. Neutralizing antibodies against more than one virus was found in a number of the sera. The significance of these findings is discussed.",Embase,March 31, 2016,Yes,,No,"Zika, indirect evidence or other topic",Scientific (journal) article,Unknown/unclear,Original research,No,Yes,3,Clinical/epidemiological research,Cross-sectional study
4,"Smithburn, Zeitschrift fur Hygiene und Infektionskrankheiten, 1952",Smithburn,"Smithburn, K. C.",Species of neurotropic virus recently discovered in Africa. [German],Zeitschrift fur Hygiene und Infektionskrankheiten,134,2,212-218,1952,1950-1959,,8282324,,1807,German,http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emcl1&AN=0008282324,"(Smithburn) Div. of Med. and Hlth., Rockefeller Found., New York, NY, United States, K.C. Smithburn, Div. of Med. and Hlth., Rockefeller Found., New York, NY, United States",,,,,"Africa, blood, epidemic, epidemiological data, female, fever, forest, human, non profit organization, species, Uganda, virus, yellow fever, blocking antibody","A review of the species of neurotropic virus, recently discovered accidentally in Africa during investigations on yellow fever in the Rockefeller Foundation. The following viruses are involved: Bwamba fever 1937-1938, western Nile 1937, Semliki forest 1942, Bunyamwera 1943, Ntaya 1943, Uganda 1947, Zika 1947/48. The epidemiological data regarding each of these 7 species of virus are briefly reviewed. Five of these species have so far only been isolated from gnats and no relationship with human diseases could be established. Only Bwamba fever gives rise to an epidemic disease, which is observed in Uganda. The western-Nile virus was also isolated from the blood of a sick woman and found to be the cause of her disease.",Embase,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Yes,Review,No,Yes,4,Clinical/epidemiological research,Epidemiological/clinical review
5,"Reagan, Tex Rep Biol Med, 1953",Reagan,"Reagan, R. L.; Brueckner, A. L.",Comparison by electron microscopy of the Ntaya and Zika viruses,Tex Rep Biol Med,11,2,347-51,1953,1950-1959,January 1, 1953,13077401,,1493,English,http://www.ncbi.nlm.nih.gov/pubmed/13077401,,,,,,"*Electrons; *Microscopy; *Microscopy, Electron; *Viruses",,Pubmed,March 31, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Original research,No,Yes,5,Basic and applied biomedical research,Other basic research
6,"Dick, Trans R Soc Trop Med Hyg, 1953",Dick,"Dick, G. W.","Epidemiological notes on some viruses isolated in Uganda; Yellow fever, Rift Valley fever, Bwamba fever, West Nile, Mengo, Semliki forest, Bunyamwera, Ntaya, Uganda S and Zika viruses",Trans R Soc Trop Med Hyg,47,1,13-48,1953,1950-1959,January 1, 1953,13077697,,1492,English,http://www.ncbi.nlm.nih.gov/pubmed/13077697,,,,,,Animals; *Flavivirus; *Forests; Humans; *Rift Valley Fever; Uganda; Virus Diseases/*epidemiology; *Viruses; *Yellow Fever; *VIRUS DISEASES/epidemiology,,Pubmed,March 31, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Yes,Review,No,Yes,6,Clinical/epidemiological research,Epidemiological/clinical review
7,"Southam, Cancer Research, 1953",Southam,"Southam, C. M., Epstein, J. D.",The effect of Russian encephalitis and other viruses on mouse leukemia,Cancer Research,13,8,581-586,1953,1950-1959,,7337538,,1806,English,http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emcl1&AN=0007337538,"(Southam, Epstein) Div. of Exp. Path., Sloan-Kettering Inst. for Cancer Res., New York, NY, United States, C.M. Southam, Div. of Exp. Path., Sloan-Kettering Inst. for Cancer Res., New York, NY, United States",,,,,"amnion fluid, Anopheles, brain, chorioallantois, donor, encephalitis virus, injection, inoculation, intraperitoneal drug administration, leukemia, leukocytosis, mouse, mouse strain, murine leukemia, spleen, survival time, suspension, tick borne encephalitis, Uganda, vaccinia, Vaccinia virus, virus","The inhibition of the leukocytosis and leukemic  infiltration of mouse leukemia by concurrent in  fection with West Nile and Ilheus viruses has been  previously reported (8). There was slight, but  probably insignificant, prolongation of survival  time in those studies. The present paper reports  a similar effect of Russian spring-summer en  cephalitis virus (R.S.S.E.) and presents results of a  survey study of the effects of fourteen other virus  infections upon mouse leukemia. The literature  concerning antileukemic effects of viruses has been  reviewed in a previous publication (8), and the  broader field of the oncolytic effects of viruses in  experimental animals and man has also been  recently reviewed (9, 10).",Embase,March 31, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Original research,No,Yes,7,Basic and applied biomedical research,Animal experiment
8,"Macnamara, Trans R Soc Trop Med Hyg, 1954",Macnamara,"Macnamara, F. N.",Zika virus: a report on three cases of human infection during an epidemic of jaundice in Nigeria,Trans R Soc Trop Med Hyg,48,2,139-45,1954,1950-1959,March 1, 1954,13157159,,1491,English,,,,,,,"*Epidemics, Humans, Jaundice/*complications, Nigeria, *Virus Diseases, *JAUNDICE/complications",,Pubmed,March 31, 2016,Yes,,No,"Zika, not relevant to causality framework",Scientific (journal) article,Yes,Original research,No,Yes,8,Basic and applied biomedical research,Animal experiment
9,"Smithburn, Journal of Immunology, 1954",Smithburn,"Smithburn, K. C.",Antigenic relationships among certain arthropod-borne viruses as revealed by neutralization tests,Journal of Immunology,72,5,376-388,1954,1950-1959,,7367626,,1802,English,http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emcl1&AN=0007367626,"(Smithburn) Labs. of Div. of Med., Publ. Hlth., Rockefeller Found., New York, NY, United States, K.C. Smithburn, Labs of Div. of Med., Publ. Hlth., Rockefeller Found., New York, NY, United States",United States,Americas,,Not reported/unknown,"Anopheles, Arbovirus, arthropod, convalescence, cross reaction, dengue, diagnosis, encephalitis, infection, Japanese, laboratory, monkey, Papua New Guinea, pathogenicity, serodiagnosis, serum, Swiss Webster mouse, Uganda, United States, virus, yellow fever, antiserum, tetanus toxoid","A survey of the literature indicates that at least 12 viruses known, or presumed, to be arthropod-borne may be interrelated. This report concerns itself with attempts to re-examine and extend the findings on this interrelationship. This is deemed important because: (1) an immunizing agent may be obtained from a virus with low pathogenicity, and (2) the effect of group reactions on diagnosis and surveys may be of value. The viruses employed were: Murray Valley encephalitis, type 2 (New Guinea) dengue, California, Iouping ill, Bwamba, West Nile, Semliki, Bunyamwera, Utaya, Zika, Uganda S, Anopheles A and B, Wyeomyia, Ilheus, St. Louis, Japanese B, Russian, type 1 dengue, E.E.E., W.E.E., V.E.E., and yellow fever. These viruses are all neurotropic for Swiss mice. The methods of study were: (1) cross-neutralization tests with univalent laboratory-produced monkey antisera, (2) the use of bivalent monkey antisera, (3) analysis of survey data from areas involved, and (4) the use of convalescent sera from cases. Cross reactions were obtained among many of the viruses studied. The possibility that this cross reaction, at least with convalescent sera, may be due to previous infection is mentioned.",Embase,March 31, 2016,Yes,,No,"Zika, indirect evidence or other topic",Scientific (journal) article,Yes,Original research,No,Yes,9,Basic and applied biomedical research,In vitro experiment
10,"Smithburn, Am J Trop Med Hyg, 1954",Smithburn,"Smithburn, K. C., Taylor, R. M., Rizk, F., Kader, A.",Immunity to certain arthropod-borne viruses among indigenous residents of Egypt,Am J Trop Med Hyg,3,1,Sep 18,1954,1950-1959,,7367261,,1804,English,http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emcl1&AN=0007367261,"(Smithburn, Taylor, Rizk, Kader) Labs. of Div. of Med., Publ. Hlth., Rockefeller Found., New York, NY, United States, K.C. Smithburn, Labs. of Div. of Med., Publ. Hlth., Rockefeller Found., New York, NY, United States",United States,Americas,United States,Not reported/unknown,"Arbovirus, blood, Egypt, immunity, Japanese, Japanese encephalitis virus, serum, Uganda, virus, yellow fever, antibody","Sera from some of the inhabitants of 10 widely scattered localities in Egypt were tested for protective antibodies against the following arthropoid-borne viruses: West Nile, Ntaya, Japanese B, St. Louis, Uganda S., Zika, Semliki, Bunyamwera, Bwamba, and yellow fever. The result of this survey revealed the presence of antibodies against the West Nile and Ntaya viruses in the blood of 67.1% and 34.9% of the people examined in the above localities (except Damietta) respectively. 8.4% showed immunity to Japanese B virus, but the same sera also neutralized West Nile and Ntaya viruses, an observation from which no conclusion could be drawn. The percentage of people showing immunity to the remaining viruses is very small and in the case of yellow fever and Bwamba viruses is nil. Immunity to West Nile and Ntaya viruses is acquired very early in life.",Embase,March 31, 2016,Yes,,No,"Zika, indirect evidence or other topic",Scientific (journal) article,Unknown/unclear,Original research,No,Yes,10,Clinical/epidemiological research,Cross-sectional study
11,"Reagan, Am J Vet Res, 1954",Reagan,"Reagan, R. L., Strand, N., Brueckner, A. L.",Response of the Swiss albino mouse to several virus strains after rectal instillation,Am J Vet Res,15,54,157-158,1954,1950-1959,,7367260,,1805,English,http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emcl1&AN=0007367260,"(Reagan, Strand, Brueckner) Virus Lab., Livestock Sanit. Serv., Univ. of Maryland, College Park, MD, United States, R.L. Reagan, Virus Lab., Livestock Sanit. Serv., Univ. of Maryland, College Park, MD, United States",,,,,"albinism, Anopheles, bird disease, egg, forest, mouse, newcastle disease paramyxovirus, Uganda, virus, virus strain, yellow fever","Twelve groups of mice were exposed rectally to Bunyamwera, Bwamba, Zika, Ntaya, Wyeomyia, Uganda S., Ilheus, Anopheles 'A', Anopheles 'B', 17D yellow fever, Semliki Forest and egg-adapted Newcastle disease virus. Mice infected rectally with the Bunyamwera, Ilheus, Semliki Forest, Anopheles 'A'. and Uganda S. viruses showed nervous symptoms identical to those found in mice infected intracerebrally with these viruses. Mice infected rectally with Bwamba, Zika, Ntaya, Anopheles 'B', 17D yellow fever, egg-adapted Newcastle disease, and Wyeomyia viruses appeared normal.",Embase,March 31, 2016,No,No full-text obtained yet,,,Scientific (journal) article,Yes,Original research,No,Yes,11,Basic and applied biomedical research,Animal experiment
12,"Reagan, Tex Rep Biol Med, 1954",Reagan,"Reagan, R. L., Stewart, M. T., Delaha, E. C., Brueckner, A. L.",Response of the Syrian hamster to eleven tropical viruses by various routes of exposure,Tex Rep Biol Med,12,3,524-527,1954,1950-1959,,7368163,,1801,English,http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emcl1&AN=0007368163,"(Reagan, Stewart, Delaha, Brueckner) Virus Lab., Live Stock Sanitary Serv., Univ. of Maryland, College Park, MD, United States, R.L. Reagan, Virus Lab., Live Stock Sanitary Serv., Univ. of Maryland, College Park, MD, United States",United States,Americas,United States,Not reported/unknown,"Anopheles, Bunyamwera virus, exposure, hamster, mammal, semliki forest alphavirus, Syrian hamster, Uganda, virus, west nile flavivirus","This experiment showed that the Syrian hamster is susceptible to the Anopheles 'A' virus intracerebrally, intranasally, intralingually, intradermally, intrarectally intracardially, and intramuscularly; to the Anopheles 'B' virus intracerebrally and intracardially; to the Bunyamwera virus intracerebrally, intranasally, intralingually, intraorally, intradermally, intrarectally, intracardially, and intramuscularly; to the Bwamba virus intracardially; to the Ilheus virus intracerebrally, intranasally, intralingually, intradermally, intrarectally, intracardially, and intramuscularly; to the Ntaya virus intracerebrally, intranasally, intracardially, and intramuscularly; to the Semliki Forest virus intracerebrally, intranasally, intralingually, intradermally, intrarectally, intracardially, and intramuscularly; to the Uganda 'S' virus intracerebrally, intranasally, intralingually, intraorally, intradermally, intrarectally, intracardially, and intramuscularly; to the West Nile virus intracerebrally, intranasally, intralingually, intraorally, intradermally, intrarectally, intracardially, and intramuscularly; to the Wyeomyia virus intracerebrally, intranasally, intralingually, intrarectally, intradermally, intracardially and intramuscularly; and to the Zika virus intracerebrally.",Embase,March 31, 2016,Yes,,Yes,,Scientific (journal) article,Yes,Original research,No,Yes,12,Basic and applied biomedical research,Animal experiment
13,"Pellissier, Bull Soc Pathol Exot, 1954",Pellissier,"Pellissier, A.",Serological investigations into the incidence of neurotropical viruses in French Equatorial Africa. [French],Bull Soc Pathol Exot,47,2,223-227,1954,1950-1959,,7367286,,1803,French,http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emcl1&AN=0007367286,"(Pellissier) Inst. Pasteur, Brazzaville, A. Pellissier, Inst. Pasteur, Brazzaville",,,,,"Africa, Bunyamwera virus, complement fixation test, encephalitis virus, epidemic, guinea pig, jaundice, Poliomyelitis virus, virus, Yellow fever flavivirus, antibody","Complement fixation tests with Africans in F.E.A. revealed the presence of antibodies of Brazzaville encephalomyelitis virus, epidemic icterus virus, pulmonary guinea-pig virus and in a minor degree against allenopithecus virus. Antibodies against yellow fever virus, Bwamba, Mengo, Rift Valley , West Nile, Zika and Bunyamwera virus were also demonstrated. Antibodies against Lansing poliomyelitis virus were largely present without cases of the disease being reported. No antibodies were found against other tropical African and American viruses and several other viruses.",Embase,March 31, 2016,No,No full-text obtained yet,,,Scientific (journal) article,Yes,Original research,No,Yes,13,Clinical/epidemiological research,Cross-sectional study
14,"Reagan, Tex Rep Biol Med, 1955",Reagan,"Reagan, R. L.; Chang, S. C.; Brueckner, A. L.",Electron micrographs of erythrocytes from Swiss albino mice infected with Zika virus,Tex Rep Biol Med,13,4,934-8,1955,1950-1959,January 1, 1955,13281796,,1490,English,http://www.ncbi.nlm.nih.gov/pubmed/13281796,,,,,,"*Albinism; Animals; *Electrons; *Erythrocytes; Mice; *Microscopy; *Microscopy, Electron; *Virus Diseases; *Yellow Fever; *VIRUS DISEASES/experimental; *YELLOW FEVER/experimental",,Pubmed,March 31, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Original research,No,Yes,14,Basic and applied biomedical research,Other basic research
15,"Boorman, Trans R Soc Trop Med Hyg, 1956",Boorman,"Boorman, J. P., Porterfield, J. S.",A simple technique for infection of mosquitoes with viruses; transmission of Zika virus,Trans R Soc Trop Med Hyg,50,3,238-42,1956,1950-1959,May 1, 1956,13337908,,1489,English,,,,,,,"Animals, *Culicidae, Humans, *Viruses, *Mosquitoes",,Pubmed,March 31, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Original research,No,Yes,15,Environmental and vector research,Vector competence studies
16,"Bearcroft, Trans R Soc Trop Med Hyg, 1956",Bearcroft,"Bearcroft, W. G.",Zika virus infection experimentally induced in a human volunteer,Trans R Soc Trop Med Hyg,50,5,442-8,1956,1950-1959,September 1, 1956,13380987,,1488,English,,,Nigeria,Africa,,Not reported/unknown,"*Flavivirus, *Healthy Volunteers, Humans, *Virus Diseases, *VIRUS DISEASES/experimental",,Pubmed,March 31, 2016,Yes,,Yes,,Scientific (journal) article,Yes,Original research,No,Yes,16,Basic and applied biomedical research,Animal experiment
17,"Hale, Ann Trop Med Parasitol, 1956",Hale,"Hale, J. H., Lim, K. A., Lee, L. H.",Neutralizing antibodies against certain arthropod-borne viruses in the sera of Singapore and Borneo children,Ann Trop Med Parasitol,50,3,268-274,1956,1950-1959,,7390871,,1799,English,http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emcl1&AN=0007390871,"(Hale, Lim, Lee) Dept. of Bacteriol., Univ. of Malaya, Singapore, Malaysia, J.H. Hale, Dept. of Bacteriol., Univ. of Malaya, Singapore, Malaysia",,,,,"Arbovirus, arthropod, Borneo, child, dengue, Dengue virus, Japanese, semliki forest alphavirus, serum, Singapore, Uganda, virus, virus typing, west nile flavivirus, antibody, neutralizing antibody","Out of 96 sera from Singapore children 13%, 18% and 12% contained antibody against Japanese B, Ntaya and dengue viruses, respectively. In the sera of 18 Borneo children, antibodies were detected against Jap. B virus (44%), Ntaya virus (92%), Uganda S virus (17%), West Nile virus (17%), type 1 dengue (59%) and type 2 dengue virus (29%). A number of children possessed neutralizing antibodies against 2 or more viruses. No evidence of antibodies was found against Bunyamwera, Zika and Semliki Forest viruses.",Embase,March 31, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Original research,No,Yes,17,Clinical/epidemiological research,Cross-sectional study
18,"McLean, Australian Journal of Experimental Biology and Medical Science, 1956",McLean,"McLean, D. M.",Serological group reactions of Murray Valley encephalitis virus,Australian Journal of Experimental Biology and Medical Science,34,1,71-75,1956,1950-1959,,7571995,,1798,English,http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emcl1&AN=0007571995,"(McLean) Rockefeller Found. Virus Labs., New York, NY, United States, D.M. McLean, Rockefeller Found. Virus Labs., New York, NY, United States",,,,,"Arbovirus, arthropod, dengue, encephalomyelitis, hemagglutination, Japanese, Japanese encephalitis virus, Murray Valley encephalitis virus, semliki forest alphavirus, summer, Uganda, yellow fever","Work is cited to show that Murray Valley Encephalitis Virus (MVE) is epidemiologically like other arthropod-borne disease. Arthropod-borne viruses have been divided in groups A and B. A includes eastern, western, and Venezuelan equine encephalitis (EEE), (WEE), and (VEE), Sinbis and Semliki Forest viruses. B includes Japanese B (JBE), St. Louis (SLE), and Russian spring summer (RSSE), yellow fever (YF) and dengue types 1 and 2, West Nile (WN), and Ilheus, Ntaya, Uganda S and Zika. According to CFT and haemagglutination-inhibition tests MVE behaves like a member of group B. The possible use of haemagglutination-inhibition tests in epidemiological work is discussed.",Embase,March 31, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Review,No,Yes,18,Basic and applied biomedical research,Other basic research
19,"Bearcroft, Journal of Pathology and Bacteriology, 1957",Bearcroft,"Bearcroft, W. G. C.",The histopathology of the liver of yellow fever-infected rhesus monkeys,Journal of Pathology and Bacteriology,74,2,295-303,1957,1950-1959,,7478921,http://dx.doi.org/10.1002/path.1700740207,1795,English,http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emcl1&AN=0007478921,"(Bearcroft) Virus Res. Unit. West African Counc. for Med. Res., Yaba, Lagos, Nigeria, W.G.C. Bearcroft, Virus Res. Unit. West African Counc. for Med. Res., Yaba, Lagos, Nigeria",Nigeria,Africa,,,"autopsy, basophilia, biopsy, cell infiltration, cell nucleus inclusion body, cell vacuole, cytoplasm, hepatic vein, histopathology, infection, inflammatory cell, inoculation, liver, liver biopsy, liver cell, monkey, necrosis, needle, photography, portal vein, rhesus monkey, stroma, virus, yellow fever, methyldopa","The development of the widespread mid-zonal necrosis classically seen at autopsy in yellow fever was studied in rhesus monkeys by serial needle liver biopsies taken at intervals after infection by the virus. Three of the eight monkeys infected had been previously immunized by Zika virus. The liver, which had by previous biopsies been shown to be within normal limits, developed necrosis of diffusely scattered individual liver cells on the third post-inoculation day, the liver cells becoming shrunken and irregular with nuclear pyknosis and cytoplasmic vacuolation but with no intranuclear inclusion bodies seen. Cytoplasmic vacuolated cosinophilic bodies were sometimes seen in apparently normal cells. Necrotic cells either remained in the liver cell plate or were extruded into the sinusoids. Cells near those first affected then show an increased nuclear basophilia, followed by the development of irregular granular eosinophilic intranuclear masses. The nuclei later fragment. The cytoplasm shows vacuolatiun amd other degenerative changes. The foci increase rapidly as more cells are involved and become irregular and ultimately confluent to produce the classic picture with only a few surviving cells round the portal tracts and the hepatic vein radicles. In Zika immune animals the process developed more slowly. An inflammatory cell infiltrate was seen, together with degenerative changes, in the portal tract stroma and in the hepatic vein radicles. The liver changes are illustrated by photographs and a schematic diagram.",Embase,March 31, 2016,No,No full-text obtained yet,,,Scientific (journal) article,Unknown/unclear,Original research,No,Yes,19,Basic and applied biomedical research,Animal experiment
20,"Weinbren, Trans R Soc Trop Med Hyg, 1958",Weinbren,"Weinbren, M. P., Williams, M. C.","Zika virus: further isolations in the Zika area, and some studies on the strains isolated",Trans R Soc Trop Med Hyg,52,3,263-8,1958,1950-1959,May 1, 1958,13556872,,1487,English,,"East African Virus Research Institute, Uganda",Uganda,Africa,Uganda,Not reported/unknown,"*Flavivirus, *Viruses",,Pubmed,March 31, 2016,Yes,,Yes,,Scientific (journal) article,Yes,Original research,No,Yes,20,Basic and applied biomedical research,Animal experiment
21,"Diercks, Proceedings of the Society for Experimental Biology and Medicine, 1958",Diercks,"Diercks, F. H., Hammon, W. McD",Hamster kidney cell tissue cultures for propagation of Japanese B encephalitis virus,Proceedings of the Society for Experimental Biology and Medicine,97,3,627-632,1958,1950-1959,,7478947,,1793,English,http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emcl1&AN=0007478947,"(Diercks, Hammon) Dept. of Epidemiol. and Microbiol., Grad. Sch. of Publ. Hlth., Univ. of Pittsburgh, Pittsburgh, PA, United States, F.H. Diercks, Dept. of Epidemiol. and Microbiol., Grad. Sch. of Publ. Hlth., Univ. of Pittsburgh, Pittsburgh, PA, United States",,,,,"arthropod, cytopathogenic effect, Dengue virus, dilution, dysentery, encephalitis, epidemic encephalitis, forest, hamster, identity, infection, inoculation, Japanese, Japanese encephalitis virus, kidney cell, kidney parenchyma, laboratory, monkey, mouse, Papua New Guinea, Poliomyelitis virus, serodiagnosis, tissue culture, tissue culture cell, tube, Uganda, virus, virus culture","Monolayer hamster kidney cell (HKC) tissue cultures can be prepared on a routine basis by methods essentially identical with those currently in use for preparation of monkey kidney tissue cultures. In screen tests with 13 arthropod-borne agents and 3 types of polio virus, HKC proved markedly susceptible to the cytopathogenic effects (CPE) of Japanese B encephalitis, West Nile, Uganda S, Ilheus, Bunyamwera, and Senliki Forest viruses, only moderately susceptible to effects of the St. Louis encephalitis agent and the New Guinea C, Hawaiian, and Trinidad strains of dengue virus. In contrast, the Ntaya, Zika and Bwamba agents and the 3 types of polio virus failed to show CPE. Evidence has been presented for serial propagation of JBE virus through 8 serial transfers in HKC tissue cultures. CPE was eventually complete. After 6 passages the virus yield was greater than the starting inoculum, although the dilution factors had carried beyond the extinction point of infectivity of the original inoculum. Identity of the Japanese B encephalitis virus after 6 serial passages in tissue culture was established by neutralization tests performed both in tissue cultures and in mice, thus indicating that the test-tube procedure may prove useful as a serological tool in the laboratory.",Embase,March 31, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Original research,No,Yes,21,Basic and applied biomedical research,In vitro experiment
22,"Causey, Am J Trop Med Hyg, 1958",Causey,"Causey, O. R., Theiler, M.",Virus antibody survey on sera of residents of the Amazon Valley in Brazil,Am J Trop Med Hyg,7,1,36-41,1958,1950-1959,,7478382,,1794,English,http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emcl1&AN=0007478382,"(Causey, Theiler) Virus Lab., Belem, Brazil, O.R. Causey, Virus Lab., Belem, Brazil",Brazil,Americas,,Not reported/unknown,"Brazil, dengue, mouse, semliki forest alphavirus, serodiagnosis, serum, Uganda, virus, western equine encephalomyelitis alphavirus, yellow fever, antibody, virus antibody","Sera from residents in localities in the Amazon Valley were examined for antibodies to 14 arbour viruses by neutralization tests in mice. Viruses neutralized in high ratios were yellow fever (44.7%), Ilheus (86.2%), VEE (16.7%) and Semliki Forest virus (13.9%). Viruses neutralized in lower ratios were dengue I (9.6%), West Nile (6.1%), St. Louis (5.3%), Bunyamwera (4.7%), EEE (4.1%), Zika (4.0%), Uganda S (2.1%), dengue II (2.0%) and WEE (1.6%). Bwamba was the only virus tested for which no antibodies were found. The evidence is not conclusive that Uganda S, Zika, West Nile, St. Louis, dengue II, or WEE virus occurs in the Amazon Valley. The positive results obtained with these agents may be due to immunological overlap with other immunologically related agents.",Embase,March 31, 2016,Yes,,No,"Zika, indirect evidence or other topic",Scientific (journal) article,Unknown/unclear,Original research,No,Yes,22,Clinical/epidemiological research,Cross-sectional study
23,"Macnamara, Trans R Soc Trop Med Hyg, 1959",Macnamara,"Macnamara, F. N., Horn, D. W., Porterfield, J. S.",Yellow fever and other arthropod-borne viruses. a consideration of two serological surveys made in south western nigeria,Trans R Soc Trop Med Hyg,53,2,425-429,1959,1950-1959,,7896402,,1791,English,http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emcl1&AN=0007896402,"(Macnamara, Horn, Porterfield) West African Counc. for Med. Res., F.N. Macnamara, West African Counc. for Med. Res.",Nigeria,Africa,United Kingdom,Not reported/unknown,"Arbovirus, dengue, epidemiology, fever, forest, hypothesis, infection, mouse, Nigeria, protection, Uganda, virus, west nile flavivirus, yellow fever, antibody","Serological surveys employing mouse protection tests were made in 2 places in south-western Nigeria. A high incidence of antibodies was found against Bwamba fever, dengue, Uganda 5., yellow fever and Zika viruses; a low incidence was found against Bunyamwera, Mengo, Semliki Forest and West Nile viruses. The association of positive results in different protection tests was analysed and statistically significant associations were found at Hobi between positive results in the following pairs of viruses: Zika and dengue, Zika and Uganda S., Zika and yellow fever but not between yellow fever and Uganda S., dengue and yellow fever or Uganda S. and dengue. However, at Ilaro, yellow fever and Uganda S., did show a positive association. Amongst triads taken from this complex of 4 group B viruses<< positive tests to Zika and Uganda S. were remarkably associated with a positive test to yellow fever. Thus a positive test to Zika virus was found in nearly ail the significant associations. It is considered that serological overlap is the most likely. Although the serological overlaps may not occur with sufficient frequency to interfere seriously with the interpretation of epidemiological serological surveys, nevertheless their presence may account for certain observed abnormalities in the clinical epidemiology of Yellow fever in Nigeria. The hypothesis is advanced that the low incidence of clinical Yellow fever in certain parts of Nigeria is due to tolerance of this virus induced by prior infections with related virus.",Embase,March 31, 2016,Yes,,No,"Zika, indirect evidence or other topic",Scientific (journal) article,Unknown/unclear,Original research,No,Yes,23,Clinical/epidemiological research,Cross-sectional study
24,"Mattingly, Trans R Soc Trop Med Hyg, 1960",Mattingly,"Mattingly, P. F.",Ecological aspects of the evolution of mosquito-borne virus diseases,Trans R Soc Trop Med Hyg,54,2,97-112,1960,1960-1969,,7898800,,1789,English,http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emcl1&AN=0007898800,"(Mattingly) British Museum, London, P.F. Mattingly, British Museum, London",,,,,"adaptation, adult, Aedes, Asia, bird, blood, canopy, Culex, Cytomegalovirus, dengue, deterioration, ecology, egg, Eocene, Europe, forest, fossil, fowl, genus, habitat, hibernation, hypothesis, independence, Japanese, maturation, Mesozoic, mosquito, North America, parasite vector, plant, primate, steppe, swamp, tropics, veldt, vertebra, vertebrate, virus, virus infection, west nile flavivirus, yellow fever, zoogeography, bron","The evidence suggests that the mosquito-borne viruses assumed their present from in their arthropod vectors. This process may be presumed to have accompanied and been related to the evolution of methods of utilizing the blood meal for the maturation of the eggs. It is a reasonable assumption that the mosquitoes originally evolved during the latter part of the Mesozoic in relation to the evolution of their vertebrae hosts and of the angiospermous plants. The general pattern of hostparasite relationships in the mosquito-borne diseases suggests that the virus diseases originated in relation to avian hosts and mosquitoes of the during the early Tertiary presented by the fossil genus Culex s. str. The picture of primate evolution record suggests an origin during the Eocene in Europe and North America. This was followed by expansion into the Old and New World tropics and isolation there consequent on progressive climatic deterioration. The same may be true of the birds, but these have not been studied in the present connection. The hypothesis, based on pathological and serological evidence, that West Nile is the most primitive of the group B viruses is consistent with paras.4 and 5, and with current ideas regarding the zoogeography of the mosquitoes. The mosquito-borne viruses appear to have achieved the passage from eastern Asia into North America, but they are replaced in the central Eurasian steppes by closely related acarine-borne viruses. This is probably associated with the fact that the dominant steppe mosquitoes belong to the genus Aedes and hibernate in the egg. Similar considerations probably account for the exclusion of Aedes-borne viruses from subtropical areas where the only vectors are Culex Spp.hibernating and aestivating as adults. The foregoing consideration strongly suggests that the basic ecological factord affecting the evolution of the group B viruses have been those relating to hibernation and aestivation. It also suggests that, whatever local alternatives may exist, the mosquito vector has provided the only site of hibernation and aestivation of tne virus of sufficient importance to have affected the broad evolutionary picture in the subtropics. In the tropics adaptation to particular vertebrate hosts may have been of prime importance. The ecology of West Nile virus is insufficiently understood. It may involve arboreal vectors. St. Louis, Japanese B and Murray Valley, appear to be swamp viruses. The evolution of other group B viruses may be pictured as having accompanied the exploitation of new habitats, swamp forest (Ntaya, Ilheus), veldt with temporary pools (Wessels-bron) and the forest canopy (yellow fever, ? Zika). This has been accompanied by the transfer to aedine vectors in the tropics and acarine vectors in the steppes. Dengue-1 and 2 may have become independent of all but their secondary vectors. Bat salivary gland virus may have achieved independence of arthropod vectors altogether. The picture presented here is based on the current assumption that West Nile is the most primitive of the Group B viruses. If evidence were to be produced to the effect that the Russian SS group are more primitive this would lead to a reorientation of our approach and many interesting questions would become pertinent. The point is an important one, but it is one for the virologists. (IV, 17*).",Embase,March 31, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Review,No,Yes,24,Environmental and vector research,Ecological/Vector review
25,"Berdonneau, Bull Soc Pathol Exot, 1961",Berdonneau,"Berdonneau, R., Serie, Ch, Panthier, R., Hannoun, C. L., Papaioannou, S. Ch, Georgieff, P.",The yellow fever epidemic of 1959 in Ethiopia (Sudano-ethiopian border). [French],Bull Soc Pathol Exot,54,2,276-283,1961,1960-1969,,7402145,,1788,French,http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emcl1&AN=0007402145,"(Berdonneau, Serie, Panthier, Hannoun, Papaioannou, Georgieff) Serv. de la Fievre Jaune, Inst. Pasteur, Paris, R. Berdonneau, Serv. de la Fievre Jaune, Inst. Pasteur, Paris",,,,,"death, epidemic, Ethiopia, geographic distribution, height, hemagglutination, Israel, morbidity, patient, population, population density, season, Sudan, vaccination, virus, yellow fever, hemagglutinin","The area of geographical distribution of this epidemic was situated in the province of Wollega, which lies in co-terminus with the Sudanese frontier, and lies between the 9th and 11th north latitudes forming a quadrilateral 150 km. long and 50 km. wide, running from south-west to north-east. The high table land and the mountainous region diminish in height in the vicinity of the Sudanese plain. The villages affected by the epidemic were situated at altitudes of 500-800 m. The population density is very low. The villages are situated at considerable distances from each other. The total population of this border district is about 20,000. In September, right in the rainy season, the epidemic raged in Sudan, in the district of Southern Fung (province of the Blue Nile), comprising the region of Kurmuck and affected 114 cases, with 87 deaths. The last case occurred on December 12, 1959. In October, some villages of Ethiopia were affected. In Dull, the epidemic was stopped by means of routine vaccination, which proved that it was indeed yellow fever. Cases were noted in Seba and Beschir, Sherkole, Guizan and Gangan, from where it spread further into the Ethiopian territory, as far as Rodock and Keshankoro. The morbidity for 9 villages was 237 patients and the total number of deaths was 98. The seroprotection test and the CFT were practised. The haemagglutination inhibition reaction showed an inhibition of more than 2,560 per 4 units of haemagglutinin. The inhibition was also very high for the haemagglutinin of the following viruses: Spondweni, Dheus, Zika, West Nile and Israel-Turkey.",Embase,March 31, 2016,No,No full-text obtained yet,,,Scientific (journal) article,Yes,Original research,No,Yes,25,Clinical/epidemiological research,Cross-sectional study
26,"Fabiyi, Ann Trop Med Parasitol, 1961",Fabiyi,"Fabiyi, A.","Yellow fever at Tema, Ghana. 1959: A serological survey by complement fixation",Ann Trop Med Parasitol,55,2,235-241,1961,1960-1969,,7822325,,1787,English,http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emcl1&AN=0007822325,"(Fabiyi) Virus Res. Unit, West African Counc. for Med. Res., Yaba, Lagos, Nigeria, A. Fabiyi, Virus Res. Unit, West African Counc. for Med. Res., Yaba, Lagos, Nigeria",,,,,"antibody response, Arbovirus, complement fixation, dengue, endemic disease, epidemic, Ghana, immune response, infection, mouse, population, protection, secondary immune response, serology, serum, virus, yellow fever, antigen","Seventy-six sera from a yellow fever epidemic at Tema, Ghana, were each tested by the CF technique against 5 viral agents - yellow fever, Zika, dengue (TR 1751), West Nile and Ilesha 4 of which belonged to Casals and Brown's (1954) group B arthropod-borne viruses. The sera were selected from a number already tested in a yellow fever protection test in Swiss white mice. The results showed that: (1) By the types of immune responses, the sera could be differentiated into the following categories: class I, primary (yellow fever infection only); class II, secondary (yellow fever and one or more other members of group B viruses); class III, primary group (a single member only of group B other than yellow fever); class IV, no response (non-immune to any of the agents in the test). (2) The secondary immune response increased in the population with increase in age, and primary responses (yellow fever or group) decreased with increase in age, (3) Analysis of the results of CF and protection tests showed a high proportion of the population with antibody response to yellow fever and related antigens. This finding was taken to indicate endemicity of yellow fever and related viruses in the area.",Embase,March 31, 2016,No,No full-text obtained yet,,,Scientific (journal) article,Yes,Original research,No,Yes,26,Clinical/epidemiological research,Cross-sectional study
27,"Bres, Bull Soc Pathol Exot, 1963",Bres,"Bres, P., Lacan, A., Diop, I., Michel, R., Peretti, P., Vidal, C.",Arboviruses in senegal. a virological survey. [French],Bull Soc Pathol Exot,56,3,384-402,1963,1960-1969,,8390328,,1783,French,http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emcl1&AN=0008390328,"(Bres, Lacan, Diop, Michel, Peretti, Vidal) Inst. Pasteur, Dakar, P. Bres, Inst. Pasteur, Dakar",Senegal,Africa,Senegal,Not reported/unknown,"Arbovirus, population, Senegal, serum, Uganda, vaccination, virus, yellow fever, antibody",,Embase,March 31, 2016,Yes,,No,"Zika, indirect evidence or other topic",Scientific (journal) article,Unknown/unclear,Original research,No,Yes,27,Clinical/epidemiological research,Cross-sectional study
28,"Bres, Bulletin de la Societe Medicale d'Afrique Noire de Langue Francaise, 1963",Bres,"Bres, P., Chambon, L., Pace, Y., Lacan, A.",Arbo-viruses in senegal. i. a serological study on the human population. [French],Bulletin de la Societe Medicale d'Afrique Noire de Langue Francaise,8,6,706-709,1963,1960-1969,,8392733,,1784,French,http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emcl1&AN=0008392733,"(Bres, Chambon, Pace, Lacan) Inst. Partir. Dakar, P. Bres, Inst. Partir. Dakar",,,,,"Arbovirus, epidemic, human, population, Senegal, vaccination, virus, west nile flavivirus, yellow fever, antibody","A serological survey of 440 sera in order to demonstrate antibodies against the following arboviruses; Chinkungunya, O'Nyong-Nyong, yellow fever, Zika, Uganda S. West Nile and Bunyamwera, showed that 91% of these sera contained antibodies against at least one of these viruses. In the A group. 55.1% of the sera contained antibodies for Chinkungunya virus. In the B group, 87% of the sera contained antiamaril antibodies; however, a restriction should be made: since 1939, the population of Senegal is subjected to systematic anti-yellow fever vaccinations. (IV, 17*).",Embase,March 31, 2016,No,Duplicate of existing record,,,,,,,,,,
29,"Pond, Trans R Soc Trop Med Hyg, 1963",Pond,"Pond, W. L.",ARTHROPOD-BORNE VIRUS ANTIBODIES in SERA from RESIDENTS of SOUTH-EAST ASIA,Trans R Soc Trop Med Hyg,57,5,364-371,1963,1960-1969,,8081275,http://dx.doi.org/10.1016/0035-9203(63)90100-7,1785,English,http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emcl1&AN=0008081275,"(Pond) Walter Reed Army Inst. of Res., Washington, DC, United States, W.L. Pond, Walter Reed Army Inst. of Res., Washington, DC, United States",United States,Americas,United States,,"adolescence, adult, age distribution, Arbovirus, Asia, child, forest, Malaysia, reactor, semliki forest alphavirus, serum, Thailand, Viet Nam, virus, antibody, neutralizing antibody, virus antibody","Sera from indigenous residents of the Federation of Malaya, North Vietnam and Thailand were tested for neutralizing antibodies against numerous arthropod-borne viruses. The majority of the adult Malayans tested possessed antibodies against JE, Ntaya, Zika and MVE viruses. Many sera contained antibodies against WN, Uheus, Semliki Forest and RSSE viruses. Antibodies against 12 other arthropod-borne viruses were rarely encountered, or were absent from the Malayan sera tested. Studies on the age distribution of persons with antibodies against five of the viruses, revealed that nearly 90% of the indigenous Malayans studied possessed JE and Ntaya virus antibodies by late adolescence. Antibodies neutralizing Zika, Ilheus and Semliki Forest viruses did not reach peak incidence (40 to 70%) until the fourth decade of life. Many sera from adult Malayans contained neutralizing antibodies to several arthropod-borne viruses (JE, Ntaya, Zika, Ilheus), whereas the incidence of such reactors was significantly lower among children. A small percentage of sera from children neutralized but a single virus (JE, Ntaya or Zika). Most of the sera from 50 adult residents of Thailand contained JE, Ntaya, Semliki Forest and WN virus antibodies, while sera of only a few neutralized Zika and Ilheus viruses. The antibody pattern of the Tonkin es e of North Vietnam was similar to that of the Thais.",Embase,March 31, 2016,Yes,,No,"Zika, indirect evidence or other topic",Scientific (journal) article,Yes,Original research,No,Yes,29,Clinical/epidemiological research,Cross-sectional study
30,"Bres, Annales de l'Institut Pasteur, 1963",Bres,"Bres, P., Chambon, L.",Isolation of an arbovirus strain from the salivary glands of bats. dakar. preliminary report -. [French],Annales de l'Institut Pasteur,104,5,705-711,1963,1960-1969,,8661571,,1782,French,http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emcl1&AN=0008661571,"(Bres, Chambon) Inst. Pasteur, Dakar, P. Bres, Inst. Pasteur, Dakar",,,,,"Arbovirus, baby, mouse, salivary gland, Senegal, serum, Uganda, yellow fever, antigen, deoxycholic acid, oxygen","Arbovirus was isolated from the salivary glands of bats captured in Senegal, by 3 passages in baby mice from one of the 5 pools tested. On its third passage, the strain reached a titre of 10<sup>6</sup> DL90/O.O<inf>2</inf> ml. in baby mice, and was lyophilized with a residual titre of 10<sup>75</sup> DL<inf>50</inf>. This strain called IPD/A 249. is desoxycholate sensitive (loss of 5.5 log). An HA antigen was obtained. Preliminary IHA tests were positive with a group B polyvalent serum. In further studies with monovalent sera, no inhibition was found with yellow fever. Zika or Uganda S1 but slight inhibition with anti-West Nile serum.",Embase,March 31, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Original research,No,Yes,30,Basic and applied biomedical research,Animal experiment
31,"Serie, Ethos, 1963",Serie,"Serie, C.",MEMORANDUM on YELLOW-FEVER in ETHIOPIA 1961-1962,Ethos,1,4,206-207,1963,1960-1969,,7592036,,1786,English,http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emcl1&AN=0007592036,"(Serie) Pasteur Inst. of Ethiopia, Addis Ababa, Ethiopia, C. Serie, Pasteur Inst. of Ethiopia, Addis Ababa, Ethiopia",,,,,"Aedes, epidemic, Ethiopia, human, immunity, virus, yellow fever, Yellow fever flavivirus, antibody","The further development of the yellow fever epidemic is summarized. Three more yellow fever strains were isolated from man, and 12 strains from pools of Aedes simpsoni, the vector responsible for the transmission from man to man. The epidemic appears to be stabilized. Serological survey showed 3 distinct zones in Southeastern Ethiopia: (1) the province of Illubabor with cross immunity of different Arbo B viruses and without epidemic yellow fever, (2) the zone Didessa and Omo valley where Zika and yellow fever virus are present, and (3) the Awash valley where no antibodies were found.",Embase,March 31, 2016,No,No full-text obtained yet,,,Scientific (journal) article,Unknown/unclear,Original research,No,Yes,31,Clinical/epidemiological research,Cross-sectional study
32,"Haddow, Bull World Health Organ, 1964",Haddow,"Haddow, A. J., Williams, M. C., Woodall, J. P., Simpson, D. I., Goma, L. K.",Twelve Isolations of Zika Virus from Aedes (Stegomyia) Africanus (Theobald) Taken in and above a Uganda Forest,Bull World Health Organ,31,1,57-69,1964,1960-1969,January 1, 1964,14230895,,1486,English,,,,,,,"*Aedes, Animals, *Culicidae, Flavivirus/classification/*isolation & purification, Forests, *Insect Vectors, Uganda, *Arbovirus, *Uganda","In continuation of a series of studies of arboreal mosquitos as virus vectors in Uganda, 12 strains of Zika virus and one strain of another Group B arbovirus were isolated between November 1961 and June 1963 from pools of Aedes (Stegomyia) africanus caught on a 120-foot (36.5-m) tower in Zika forest. For five strains it is known at what height the mosquitos were caught: one was from mosquitos taken at ground level, and the other four were from mosquitos taken in or above the upper canopy after sunset. No small mammal trapped in the forest either on the ground or in the trees showed serum antibody for Zika virus.These findings suggest that in Zika forest, A. (S.) africanus becomes infected from a virus reservoir that is probably not among the small animals tested and that infected mosquitos are liable to be spread widely beyond the forest by convection currents above the tree-tops in the first two or three hours after sunset.",Pubmed,March 31, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Original research,No,Yes,32,Environmental and vector research,Ecological/animal cross-sectional
33,"Simpson, Trans R Soc Trop Med Hyg, 1964",Simpson,"Simpson, D. I.",Zika Virus Infection in Man,Trans R Soc Trop Med Hyg,58,4,335-8,1964,1960-1969,July 1, 1964,14175744,,1485,English,,,,,,,"Animals, *Complement Fixation Tests, *Encephalitis, *Encephalitis, Arbovirus, *Encephalitis, Viral, *Hemagglutination Inhibition Tests, Humans, Male, Mice, *Research, *Virus Diseases, *Encephalitis viruses, *Encephalitis, epidemic, *Experimental lab study, *Mice","Zika virus, a group B Arbor virus, has not previously been isolated from man. The author developed a transient (3 day) mild, febrile illness with a diffuse maculepapular rash. Zika virus was isolated from serum drawn during the febrile period. A rise in Zika neutralizing and complement-fixing antibodies was demonstrated between the acute and chronic phase serum specimens.",Pubmed,March 31, 2016,Yes,,No,"Zika, not relevant to causality framework",Scientific (journal) article,Unknown/unclear,Original research,No,Yes,33,Clinical/epidemiological research,Case report
34,"Bres, Annales de l'Institut Pasteur, 1964",Bres,"Bres, P., Chambon, L.",Techniques for the study of bat infection with arbovirus under natural conditions. epidemiological significance in senegal. [French],Annales de l'Institut Pasteur,107,1,34-43,1964,1960-1969,,8162935,,1780,French,http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emcl1&AN=0008162935,"(Bres, Chambon) Inst. Pasteur, Dakar, P. Bres, Inst. Pasteur, Dakar",,,,,"Arbovirus, baby, blood, dilution, hemagglutination inhibition test, human, infection, inoculation, intracerebral drug administration, intraperitoneal drug administration, mouse, rabbit, salivary gland, Senegal, serum, Uganda, virus, west nile flavivirus, yellow fever, antibody","A study of this infection carried out on more than 3,000 insectivorous bats resulted in the isolation of 42 strains. The findings obtained with various methods of inoculation of baby mice were compared. The best technique was a simultaneous intracerebral and intraperitoneal inoculation, the use of 2 dilutions (1/20 and 1/200). and addition of non-immune rabbit serum when the ground material is toxic. Salivary glands contained more virus than blood and interscapuiar fat. All strains isolated proved identical with strain Dakar 249, which seems to be a new B group strain. Bat infection with this strain under natural conditions is very frequent in Senegal (about 1.5%). Hemagglutination inhibition tests carried out with 165 bats showed the almost exclusive presence of Dakar 249 antibodies (54% of the sera studied), and rarely that of Chikungunya antibodies (3%). In human subjects, hemagglutination inhibition tests showed that 3% of the sera studied contained antibodies against the strain Dakar 249, and were negative for yellow fever, Zika. Uganda S and West Nile viruses.",Embase,March 31, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Original research,No,Yes,34,Environmental and vector research,Ecological/animal cross-sectional
35,"Goma, Bull Entomol Res, 1965",Goma,"Goma, L. K.","The flight activity of some East African mosquitos (Diptera, Culicidae). I. Studies on a high steel tower in Zika Forest, Uganda",Bull Entomol Res,56,1,17-35,1965,1960-1969,October 1, 1965,4378566,,1484,English,http://www.ncbi.nlm.nih.gov/pubmed/4378566,,,,,,*Culicidae; Uganda,,Pubmed,March 31, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Original research,No,Yes,35,Environmental and vector research,Other ecological
36,"Panthier, Annales de l'Institut Pasteur, 1965",Panthier,"Panthier, R., Hannoun, C., De Looze, L.",Examination of sera taken in ethiopia 1954-1961 for the presence of anti-amaril and anti-arboviruses antibodies. [German],Annales de l'Institut Pasteur,109,2,204-227,1965,1960-1969,,7653517,,1776,German,http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emcl1&AN=0007653517,"(Panthier, Hannoun, De Looze) Serv. de la Fievre Jaune et des Arbovirus, Inst. Pasteur, Paris, R. Panthier, Serv. de la Fievre Jaune et des Arbovirus, Inst. Pasteur, Paris",,,,,"Arbovirus, city, epidemic, Ethiopia, etiology, examination, laboratory, mouse, protection, river, sea, serodiagnosis, serum, Sudan, virus, world health organization, yellow fever, Yellow fever flavivirus, antibody, hemagglutination inhibiting antibody","Certain sera originating from Assab on the Red Sea in Erythrea, contain antibodies against amaril virus (partial protection of mice in sero-neutralization tests). The same sera do not contain complement fixing or hemagglutination inhibiting antibodies. The virus responsible for the protecting antibody seems to be serologically related to but different from yellow fever virus. At the western border of Ethiopia, in the Wollega district, a small yellow fever epidemic had been reported at the end of 1959. It was a Sudanese epidemic (Southern Fung) which had extended to the Ethiopian plateau, along a track connecting the town Assosa in Ethiopia with the town Kurmuk in Sudan. In the parts of the Ethiopian territory situated outside the plateau, antibodies against various arboviruses are found, like in Sudan. In south-western Ethiopia where no yellow fever virus activity was demonstrated until 1954-1955, evidence was brought for its first manifestation between 1955 and 1960. The virus does not seem to have caused severe disease nor significant epidemics during this period: from 1955 to November 1960 it spread over the area situated between the Omo river and the Sudanese border; in November 1960, it induced a very severe epidemic on the left bank of the Omo river (North from Jenka), in a region where arboviruses (Zika or related virus) were rare. In October 1961 (when a survey was undertaken by several American, English and French laboratories with WHO support, the epidemic spread towards the North, on the right bank (Kaffa) and left bank (Wallamo) of the Omo river. A strain of yellow fever virus has been isolated, evidencing the amaril etiology of the epidemic.",Embase,March 31, 2016,No,No full-text obtained yet,,,Scientific (journal) article,Yes,Original research,No,Yes,36,Clinical/epidemiological research,Cross-sectional study
37,"Kokernot, Trans R Soc Trop Med Hyg, 1965",Kokernot,"Kokernot, R. H., Casaca, V. M. R., Weinbren, M. P., McIntosh, B. M.",Survey for antibodies against arthropod-borne viruses in the sera of indigenous residents of Angola,Trans R Soc Trop Med Hyg,59,5,563-570,1965,1960-1969,,7654266,http://dx.doi.org/10.1016/0035-9203(65)90159-8,1775,English,http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emcl1&AN=0007654266,"(Kokernot, Casaca, Weinbren, McIntosh) Univ. of Illinois, Chicago, IL, United States, R.H. Kokernot, Univ. of Illinois, Chicago, IL, United States",,,,,"adult, Angola, Arbovirus, child, dengue, donor, fever, forest, mouse, population, prevalence, rift valley fever bunyavirus, serodiagnosis, serum, United States, virus, yellow fever, antibody","Sera collected in 1960 from 492 indigenous residents of 14 widely scattered localities in Angola were tested for HI antibodies against 18 viruses: 5 from Group A, 9 from Group B, 1 from Group C, 2 from the Bunyamwera Group, and Rift Valley fever virus. Results of these tests indicated that the prevalence of antibodies was greatest in the 6 localities sampled in the north-western coastal and plateau region. Sera positive in the HI test were further tested with the respective viruses by mouse neutralization test. Analysis of these results according to sera positive for only 1 virus of Group A, B or Bunyamwera indicated that Sindbis, chikungunya, Semliki Forest, Wesselsbron, Zika, H 336, West Nile. Bunyamwera and Germiston viruses have been active, predominantly in the north-western region, and that Spondweni virus has been present. There was no evidence that Mayaro or Middelburg virus has infected the population sampled, or that Ntaya, dengue 1 or dengue 2 virus has been present. In 3 localities in the north-west interpretation of results with Group B viruses was complicated by the fact that some of the donors had been vaccinated against yellow fever. HI test results with Oriboca virus suggest that this or a closely related member of Group C exists in Angola. In additional neutralization tests, 1 or more sera from children and adults in each of the 6 north-western localities protected against Lumbo (California complex), Pongola or Bwamba fever virus.",Embase,March 31, 2016,Yes,,No,"Zika, indirect evidence or other topic",Scientific (journal) article,Yes,Original research,No,Yes,37,Clinical/epidemiological research,Cross-sectional study
38,"Bres, Annales de l'Institut Pasteur, 1965",Bres,"Bres, P., Carrie, J., Desbois, A., Lartigue, J. J., Mace, G.",The arboviruses in haute volta. A serological survey. [French],Annales de l'Institut Pasteur,108,3,341-352,1965,1960-1969,,7653310,,1777,French,http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emcl1&AN=0007653310,"(Bres, Carrie, Desbois, Lartigue, Mace) Inst. Pasteur de Dakar, P. Bres, Inst. Pasteur de Dakar",,,,,"Africa, Arbovirus, epidemic, hemagglutination inhibition test, population, serum, Uganda, vaccination, virus, yellow fever, antibody","A total of 1.896 human sera, taken in 1963-1964 in Haute Volta (tropical Africa), were studied by means of the hemagglutination inhibition test. The results show that only 5.4% of the population was totally deprived of antibodies against the arboviruses studied: Chinkungunya, O'nyong-nyong, yellow fever, Uganda S., West Nile, Zika and Bunyamwera. It seemed that a massive epidemic, due to a group A virus (probably O'nyong-nyong) had recently occurred. The other viruses appeared to be endemic. Concerning yellow fever, no conclusion could be reached because of the presence of antibodies due to systematic vaccination.",Embase,March 31, 2016,No,No full-text obtained yet,,,Scientific (journal) article,Yes,Original research,No,Yes,38,Clinical/epidemiological research,Cross-sectional study
39,"Chippaux-Hyppolite, Bull World Health Organ, 1966",Chippaux-Hyppolite,"Chippaux-Hyppolite, C., Chippa, U. A.",YELLOW FEVER ANTIBODIES in CHILDREN of the CENTRAL AFRICAN REPUBLIC. [French],Bull World Health Organ,34,1,105-111,1966,1960-1969,,8274582,,1774,French,http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emcl1&AN=0008274582,"(Chippaux- Hyppolite, Chippa U) Inst. Pasteur. Bangui, C. Chippaux- Hyppolite, Inst. Pasteur. Bangui",,,,,"adolescent, aged, Arbovirus, bullet, Central African Republic, child, forest, groups by age, hemagglutination, immunity, infant, mouse, serodiagnosis, serum, Uganda, vaccination, virus, yellow fever, Yellow fever flavivirus, antibody, antigen","The results are presented of a survey for yellow fever antibodies carried out on 1313 sera from infants and adolescents (aged 1-19) living in seven different regions of the Central African Republic (Bangui, Pygmy villages, Lobaye. Yaloke, Bouar, Bambari, Obo). The haemagglutinating-inhibition (HI) test was performed on all sera and the neutralization test (NT) in mice was used as a corroborative measure on 7.5% of the sera. Haemagglutination antigens were prepared with yellow fever virus and with the following group B arboviruses: Uganda S4 Wesselsbron, West Nile and Zika. Results are classified by age-group (0-4. 5-9, 10-14. 15-19 years) and the number of sera.tested in each group was sufficient for definite conclusions to be rawn for four regions (Bangui, Pygmy villages, Lobayef Yaloke); for the other three regions the results are more tentative. The neutralization test was performed on 99 sera taken at random over the four age groups; 60 were found to be negative, 32 positive, and 7 doubtful. Correlation with the results of the HI test was obtained with all 60 negative sera and with 28 of the positive sera, the remaining four NT*positive sera being HI-negative. The HI test results show that no child less than 5 years old had antibodies to yellow fever and that most of the Pygmies also lacked immunity; neither of these groups had been vaccinated. In contrast, yellow fever antibodies were present in the sera of all the other groups examined (25% positive at Obo. 41% positive at Yaloke). These findings emphasize the value of systematic vaccination, which took place in the Republic from 1944 to 1960. The existence of antibodies in the sera of a small percentage of Pygmies may reflect the presence, in the forest zone, of a wild yellow fever virus. As regards the other group B arboviruses, 6% of sera contained antibody (sometimes in high titre) to Zika virus, 2.3% to West Nile, over 1% to Wesselbron and less than 0.5% to Uganda S.",Embase,March 31, 2016,Yes,,No,"Zika, indirect evidence or other topic",Scientific (journal) article,Yes,Original research,No,Yes,39,Clinical/epidemiological research,Cross-sectional study
40,"Chambon, Bull World Health Organ, 1967",Chambon,"Chambon, L., Wone, I., Bres, P., Cornet, M., Ly, C., Michel, A., Lacan, A., Robin, Y., Henderson, B. E., Williams, K. H., Camain, R., Lambert, D., Rey, M., Diop Mar, I., Oudart, J. L., Causse, G., Ba, H., Martin, M., Artus, J. C.",A yellow fever epidemic in senegal in 1965 the human epidemic. [French],Bull World Health Organ,Wld. Hlth. Org. 36,1,113-150,1967,1960-1969,,8703615,,1771,French,http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emcl1&AN=0008703615,"(Chambon, Wone, Bres, Cornet, Ly, Michel, Lacan, Robin, Henderson, Williams, Camain, Lambert, Rey, Diop Mar, Oudart, Causse, Ba, Martin, Artus) Inst. Pasteur, Dakar, L. Chambon, Inst. Pasteur, Dakar",,,,,"adult, Africa, aged, child, city, clinical study, death, emergency, epidemic, fatality, human, immunity, infection, infectious hepatitis, juvenile, mass immunization, Mauritania, morbidity, mosquito, only child, patient, population, revaccination, risk, savanna, season, Senegal, serology, serum, speech, vaccination, virus, yellow fever, Yellow fever flavivirus, chlorphenotane, vaccine","An epidemic of urban yellow fever occurred in Senegal in 1965, in a region of dry savanna some 3,000 km<sup>2</sup> in area around the town of Diourbel. The human population of this area, about 150,000, is largely divided among villages of from 200 to 1,000 inhabitants. The population at risk consisted almost exclusively of the 50,000 children under 12 yr of age. Mosquito-eradication and mass vaccination campaigns had wiped out yellow fever in French-speaking Africa by 1953. The Dakar vaccine used caused a certain proportion of encephalitic complications among children; it was therefore decided in 1960 to cease systematic vaccination of children under 10 yr of age, and to build up a stock of 17D vaccine for use on children in an emergency. Routine serological tests had indicated the need for revaccination of the child population in Senegal at about the time that the epidemic broke out. The first confirmed case of yellow fever was announced on 12 November 1965; the first fatal case revealed by subsequent inquiries was on 7 October, but it is probable that the start of the epidemic dated back to the beginning of the rainy season in July of 1965. Prompt antimosquito, vaccination and sanitary measures terminated the epidemic by 6 December 1965, although isolated cases were recorded up to 15 January 1966. The morbidity has been variously estimated as between 2,000 and 20,000 and the case-fatality rate may have been of the order of 15%; about 90% of the deaths were among children less than 10 yr of age. Virological studies on sera from 106 children with yellow fever aged from 4 mth to 13 yr from the focus of the epidemic allowed the isolation of 16 strains of virus, antigenically identical with the French neurotropic strain. Serological studies of 38 pairs of sera from patients aged up to 10 yr from the village of N'Goye in the epidemic zone gave evidence of the development of infection in 19 cases; in 9 of these cases, the virus had also been isolated. Further serological studies on more than 1,000 sera from outside the focus of the epidemic showed the presence of immunity in about 5% of the cases, although in some areas the immunity level was considerably higher. These studies also confirmed the activity of West Nile and Zika virus in the region. A relatively thorough clinical study of 67 patients showed that many of the classical clinical signs of yellow fever were missing in most patients, largely owing to their youth. The situation was also complicated by a simultaneous epidemic of acute infective hepatitis. It may be concluded that there is a risk that an epidemic of yellow fever might be overlooked for some considerable time where only children are susceptible, as in the present case, unless special attention is paid to this possibility. The measures taken to stamp out the epidemic were 3-fold: mosquito eradication, vaccination and sanitary measures. The DDT spraying campaign was so effective that within 5 days of the declaration of the epidemic, only 159 adult mosquitoes could be captured in the epidemic zone - insufficient to allow the isolation of yellow fever virus. Nearly 2,000,000 vaccinations were carried out between mid-November 1965 and mid-January 1966, about 120,000 with 17D vaccine and the rest with Dakar vaccine. In view of the urgency of the situation, it was decided to lower the minimum age for administration of the Dakar vaccine from 10 yr to 2 yr in the epidemic zone and to 5 yr in the rest of the region involved, including the town of Dakar. The use of the Dakar vaccine led to 240 cases of meningo-encephalitic complications, nearly all in Dakar itself; in 25 of these cases, the vaccinee died. No meningo-encephalitic complications were observed in the epidemic zone, although the minimum age for vaccination was much lower there. A careful sanitary check on all routes out of the epidemic zone allowed only 3 persons suffering from yellow fever to leave this region; 2 of these died in Dakar, and one at the border between Senegal and Mauritania.",Embase,March 31, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Original research,No,Yes,40,Clinical/epidemiological research,Ecological study/outbreak report
41,"Salaun, Bull World Health Organ, 1967",Salaun,"Salaun, J. J.",The arboviruses in the cameroons. a serological investigation. [French],Bull World Health Organ,Wld Hlth Org. 37,3,343-361,1967,1960-1969,,7804863,,1772,French,http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emcl1&AN=0007804863,"(Salaun) Serv. de Virol., Inst. Pasteur du Cameroun, Yaounde, J.J. Salaun, Serv. de Virol., Inst. Pasteur du Cameroun, Yaounde",,,,,"Arbovirus, bird, Cameroon, child, desert, epidemic, forest, hemagglutination inhibition test, human, insect, littoral, mammal, serum, Uganda, urea nitrogen blood level, virology, virus, yellow fever, antibody, antigen","Following studies on insects and animals carried out by the Virology Department of the Institut Pasteur, Cameroons, the authors have made an epidemiological study of arboviruses in man, performed on 3,612 human sera according to the Clark and Casals hemagglutination-inhibition test. The following antigens were used: Group A chikungunya. o'nyong-nyong, Sindbis and Middelburg; Group B = Ntaya, Uganda S, West Nile. Zika, Spondweni and the French neurotropic strain of yellow fever; Group BUN = Bunyamwera and YM 50-64 Yaounde. A positve reaction was noted in 59% of the sera, signifying widespread disease due to arboviruses in the Cameroons. From serologic al data the country may be divided into 3 regions: the southern littoral and forest zone, the central plateaux and the northern desert strip. In Group A, chikungunya and o'nyong-nyong reactions were weak in the south (15% positive under 20 years of age), while in the center this percentage was almost doubled. In the north, half the children under 5 years had a strongly positive reaction, showing that a recent epidemic due to o'nyong-nyong or chikungunya must have taken place in the northern Cameroons. Sindbis and Middelburg viruses were practically nonexistent in the region. Group B viruses also showed a geographical variation, being common in the couth, weak in the center and very prevalent in the north. Zika and yellow fever antibodies were very common. The latter, isolated or in association with other viruses, were particularly noted in the south but exceptional in the central Cameroons. Bunyamwera group arboviruses may invade man but this is very rare. Man is probably not the reservoir of the isolated Ntaya, Middelburg and Spondweni strains. The logical sequence of these findings should be an investigation of other mammals and birds as a possible reservoir of arboviruses. (17, 4).",Embase,March 31, 2016,Yes,,No,"Zika, indirect evidence or other topic",Scientific (journal) article,Yes,Original research,No,Yes,41,Clinical/epidemiological research,Cross-sectional study
42,"Robin, Bull Soc Pathol Exot, 1968",Robin,"Robin, Y., Bres, P., Lartigue, J. J.",Arboviruses in ivory coast. [French],Bull Soc Pathol Exot,61,6,833-845,1968,1960-1969,,8234849,,1762,French,http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emcl1&AN=0008234849,"(Robin, Bres, Lartigue) Inst. Pasteur, Dakar, Y. Robin, Inst. Pasteur, Dakar",,,,,"Arbovirus, cote d'ivoire, forest, hemagglutination inhibition test, littoral, savanna, serum, Uganda, yellow fever, antigen","A serological survey was carried out in the Ivory Coast by means of hemagglutination inhibition tests towards 6 antigens on 1944 serum samples collected in 1963 and 1965. The highest incidence was observed in the Sudanese savannah. The incidence was lower in the forest and littoral zones. There was evidence of occurrence off yellow fever, chikungunya, Uganda S, West Nile, Zika and Bunyamvera.",Embase,March 31, 2016,No,No full-text obtained yet,,,Scientific (journal) article,Yes,Original research,No,Yes,42,Clinical/epidemiological research,Cross-sectional study
43,"Simpson, Ann Trop Med Parasitol, 1968",Simpson,"Simpson, D. I. H., O'Sullivan, J. P.",Studies on arboviruses and bats (Chiroptera) in East Africa. 1. Experimental infection of bats and virus transmission attempts in Aedes (Stegomyia) aegypti (Linnaeus),Ann Trop Med Parasitol,62,4,422-431,1968,1960-1969,,8100035,,1767,English,http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emcl1&AN=0008100035,"(Simpson, O'Sullivan) East African Virus Res. Inst., Entebbe, D.I.H. Simpson, East African Virus Res. Inst., Entebbe",,,,,"Aedes aegypti, Africa, Arbovirus, bat, Bunyamwera virus, Cytomegalovirus, experimental infection, fruit, infection, mosquito, Phlebotomus, salivary gland, species, Uganda, viremia, virus, virus transmission, yellow fever, Yellow fever flavivirus","Three species of East African bats were inoculated i.p. with a variety of arboviruses which ofcur in Uganda. Yellow fever and Bunyamwera viruses circulated in considerable quantity in the fruit bats Eidolon and Rousettus, and also in Tadarida. Zika virus circulated in some of the fruit bats, but not in Tadarida. Sindbis produced demonsble viraemia in a single Eidolon, while yellow fever (French nepurotropic) virus circulated in some of both the species of fruit bat tested. Ntaya, West Nile, Entebbe bat salivary gland, Usutu and yellow fever (Phlebotomus) viruses did not produce demonstrable viraemia in the fruit bats tested, and in Tadarida Ntaya, yellow fever (Phlebotomus) and Zika viruses gave negative results. Transmission attempts with 2 viruses isolated from bats (Entebbe bat salivary gland and Bukalasa bat) in Aedes (Stegomyia) aegypti were not successful, although Entebbe bat salivary gland virus was maintained for 21 days in some of the mosquitoes. The mechanism of transmission of these viruses from bat to bat is discussed.",Embase,March 31, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Original research,No,Yes,43,Basic and applied biomedical research,Animal experiment
44,"Digoutte, Bull Soc Pathol Exot, 1968",Digoutte,"Digoutte, J. P., Nguyen Tzung Luong, P.",Study on arboviruses in Central Africa. 1. Immunological study in man in the centre and western portion of the Central African Republic. [French],Bull Soc Pathol Exot,61,6,803-833,1968,1960-1969,,8712967,,1761,French,http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emcl1&AN=0008712967,"(Digoutte, Nguyen Tzung Luong) Inst. Pasteur, Bangui, J.P. Digoutte, Inst. Pasteur, Bangui",,,,,"Africa, Arbovirus, Central Africa, Central African Republic, child, epidemic, forest, human, population, savanna, serum, Uganda, virus, yellow fever, antibody, antigen","A serological survey was made on 5553 sera selected in the central and western areas of the Centrafrican Republic. Antigens used were: group A: Chikungunya, ONyong Nyong, Sindbis; group B: French Neutropic Strain of Yellow Fever, Uganda S1 West Nile, Zika; group Bunyamvera: Bunyamvera. In the forest area positive reactions to group A and B viruses are not numerous. The savanna forest border line marks the southern limit of the Chikungunya ONyong Nyong epidemic. Virus incidence of group B is low but West Nile and Zika have been found. In the arboreous savanna area antibodies to group A, Chikungunya ONyong Nyong, are found in a large proportion of the population. The activity of the group B viruses is weak but yellow fever antibodies occur in unvaccinated children. Chikungunya ONyong Nyong antibodies are found less often in forest areas than in savanna. Group B viruses are seldom found but West Nile, Zika and UGS are present. This area is the only one where Sindbis exists. In all four areas the Bunyamvera group is not important.",Embase,March 31, 2016,No,No full-text obtained yet,,,Scientific (journal) article,Yes,Original research,No,Yes,44,Clinical/epidemiological research,Cross-sectional study
45,"Digoutte, Bull Soc Pathol Exot, 1968",Digoutte,"Digoutte, J. P.",Study on arboviroses in central africa. I. Immunological study in man in the centre and western portion of the central african republic. [French],Bull Soc Pathol Exot,61,6,803-833,1968,1960-1969,,8234042,,1763,French,http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emcl1&AN=0008234042,"(Digoutte) Inst. Pasteur, Bangui, J.P. Digoutte, Inst. Pasteur, Bangui",,,,,"Africa, Arbovirus, Central Africa, Central African Republic, child, epidemic, forest, human, population, savanna, serum, Uganda, virus, yellow fever, antibody, antigen","A serological survey was made on 5553 sera selected in the central and western areas of the Centrafrican Republic. Antigens used were: group A: Chikungunya, ONyong Nyong, Sindbis; group B: French Neutropic Strain of Yellow Fever, Uganda S1 West Nile, Zika; group Bunyamvera: Bunyamvera. In the forest area positive reactions to group A and B viruses are not numerous. The savanna forest border line marks the southern limit of the Chikungunya ONyong Nyong epidemic. Virus incidence of group B is low but West Nile and Zika have been found. In the arboreous savanna area antibodies to group A, Chikungunya ONyong Nyong, are found in a large proportion of the population. The activity of the group B viruses is weak but yellow fever antibodies occur in unvaccinated children. Chikungunya ONyong Nyong antibodies are found less often in forest areas than in savanna. Group B viruses are seldom found but West Nile, Zika and UGS are present. This area is the only one where Sindbis exists. In all four areas the Bunyamvera group is not important.",Embase,March 31, 2016,No,Duplicate of existing record,,,,,,,,,,
46,"Serie, Bull World Health Organ, 1968",Serie,"Serie, C., Casals, J., Panthier, R.",Yellow fever in Ethiopia. II. Serological study of the human population. [French],Bull World Health Organ,Wld. Hlth. Org. 38,6,843-854,1968,1960-1969,,8222619,,1766,French,http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emcl1&AN=0008222619,"(Serie, Casals, Panthier) Inst. Pasteur d'Ethiopie, Addis Abeba, Ethiopia, C. Serie, Inst. Pasteur d'Ethiopie, Addis Abeba, Ethiopia",,,,,"Arbovirus, epidemic, epidemiology, Ethiopia, follow up, France, general aspects of disease, hemagglutination inhibition, human, immune response, laboratory, patient, population, river, serodiagnosis, serum, United States, virus, west nile flavivirus, yellow fever, Yellow fever flavivirus, antibody, virus antibody","Among a total of 3690 serum samples taken from unvaccinated persons during the period 1961/64 in the course of investigations of the 1960/62 yellow fever epidemic in Ethiopia, 1773 samples were serologically examined in laboratories in Addis Ababa, Entebbe, Dakar, Paris and New York. The hemagglutination inhibition, cf and neutralization tests were used; the results from the 5 laboratories were in good agreement. Analysis of the results indicates the presence of 3 epidemiologically distinct areas in Ethiopia. The first is the epidemic sector, comprising the Omo and Didessa river valleys and Sidamo Province, in which the sera show a primary type of immune response. In the second area (Western Ethiopia) there have been no outbreaks of yellow fever but antibodies are present to other group B arboviruses, while in the third (Upper Nile valley and Ogaden Province) no ar bo virus antibodies were detected. It is thought that the yellow fever virus was accompanied by Zika virus in the epidemic sector, as the latter appears to be a recent intruder among a population previously not in contact with arboviruses. In that part of the nonepidemic sector where arboviruses circulate. West Nile virus is predominant. In Manera village, which was affected by the epidemic between November 1961 and March 1962 and in which 17 yellow fever strains were isolated, a follow up study was carried out over 18 months among 90 persons with no clinical signs of any illness. Among these there were 4 conversions to yellow fever seropositivity and 1 Zika virus conversion. However, Zika virus could not be isolated either from the latter or from a patient, also showing Zika virus conversion, who was followed up for 9 months after a febrile episode.",Embase,March 31, 2016,Yes,,No,"Zika, indirect evidence or other topic",Scientific (journal) article,Yes,Original research,No,Yes,46,Clinical/epidemiological research,Cross-sectional study
47,"Andral, Bull World Health Organ, 1968",Andral,"Andral, L., Bres, P., Serie, C.",Yellow fever in Ethiopia. III. Serological and virological study of the forest fauna. [French],Bull World Health Organ,Wld. Hlth. Org. 38,6,855-861,1968,1960-1969,,8222620,,1765,French,http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emcl1&AN=0008222620,"(Andral, Bres, Serie) Inst. Pasteur d'Ethiopie, Addis Abeba, Ethiopia, L. Andral, Inst. Pasteur d'Ethiopie, Addis Abeba, Ethiopia",Ethiopia,Africa,France,,"Arbovirus, bird, brain, Colobinae, epidemic, epidemiology, Ethiopia, fauna, forest, fowl, Guinea, infection, monkey, rodent, serum, virus, yellow fever, Yellow fever flavivirus, antibody","As part of an epidemiological investigation of the 1960 to 1962 yellow fever epidemic in Ethiopia, serological and virological studies of the silvatic reservoir of virus, largely among animals shot or captured in the forest near the Manera experimental station, were carried out. In this area, all of 16 monkey sera from the Chouchouma valley in 1962 contained yellow fever antibody; this was the only arbovirus antibody in 5OX of the sera and it was found together with Zika or group A antibody in the remainder. In 1964, 25% of monkey sera were devoid of all arbovirus antibody, and a mere 18% and 25% respectively, had only yellow fever antibody or mixed antibody. The number of sera positive for group A had doubled in 1964. Similar serological study of 140 bat sera showed only 3.5% to harbor any arbovirus antibody, and only 4 sera to have yellow fever antibody. Sera from rodents, other forest animals and birds gave almost uniformly negative results, antibody for arboviruses being found in only a civet and 2 birds (one of these, a guinea fowl, had a 1/40 HI titer for yellow fever virus). Attempts to isolate yellow fever virus were successful in 2 instances - once from the brain of a bat, and once from the brain of a month old Colobus monkey that was captured alive and died 8 days later, apparently of gastroenteric infection.",Embase,March 31, 2016,Yes,,Yes,,Scientific (journal) article,Unknown/unclear,Original research,No,Yes,47,Environmental and vector research,Ecological/animal cross-sectional
48,"Serie, Bull World Health Organ, 1968",Serie,"Serie, C., Andral, L., Poirier, A.",Yellow fever in Ethiopia. VI. Epidemiological study. [French],Bull World Health Organ,Wld Hlth Org 38,6,879-884,1968,1960-1969,,8099153,,1768,French,http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emcl1&AN=0008099153,"(Serie, Andral, Poirier) Inst. Pasteur d'Ethiopie, Addis Abeba, C. Serie, Inst. Pasteur d'Ethiopie, Addis Abeba",,,,,"adult, baboon, child, death, epidemic, epidemiology, Ethiopia, female, foraging, forest, human, infection, monkey, morbidity, population, river, virus, yellow fever, Yellow fever flavivirus, antibody","This paper of a series reporting investigations of the 1960 to 62 epidemic of yellow fever in Ethiopia is a general epidemiological study based on the findings reported in the preceding articles. The epidemic, which lasted 18 months, was widespread, affecting an area in the south east of the country of some 100,000 km2 with a total population of about 1 million, largely devoid of protective antibody. Its severity is shown by the fact that the deaths are estimated at 30,000 and the total morbidity at 100,000. Adults were slightly more frequently affected than children and men than women. Basically rural in nature and linked in the villages with the presence of A. simpsoni, the epidemic is thought to have spread in the forests by a cycle involving A. africanus and monkeys, and to have reached the villages; which were not uniformly affected, as a result of foraging visits by troops of baboons, themselves sporadically infected. The scattered human cases, almost all among men, along the Didessa river in the north of the epidemic area were probably due to infections acquired in the forests from bites by A. africanus. Studies at the experimental station at Manera indicated that serological conversions took place after the epidemic had subsided, suggesting that the virus continued to circulate, albeit in greatly attenuated form. Other serological evidence indicates that the yellow fever virus may have spread in the same area as an earlier extension of Zika virus.",Embase,March 31, 2016,Yes,,No,"Zika, not relevant to causality framework",Scientific (journal) article,Yes,Original research,No,Yes,48,Clinical/epidemiological research,Cross-sectional study
49,"Andra, Bull World Health Organ, 1968",Andra,"Andra, J. L., Bres, P., Serie, C.",Yellow lever in Ethiopia. III. Serological and virolof icel study of the forest fauna. [French],Bull World Health Organ,38,6,855-861,1968,1960-1969,,8099149,,1769,French,http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emcl1&AN=0008099149,"(Andra, Bres, Serie) Inst. Pasteur d'Ethiopie, Addis Abeba, J.L. Andra, Inst. Pasteur d'Ethiopie, Addis Abeba",,,,,"Arbovirus, bird, brain, Colobinae, epidemic, Ethiopia, fauna, forest, fowl, Guinea, infection, monkey, rodent, serology, serum, virus, yellow fever, Yellow fever flavivirus, antibody","As part of an epidemiological investigation of the 1960 to 1962 yellow fever epidemic in Ethiopia, serological and virological studies of the silvatic reservoir of virus, largely among animals shot or captured in the forest near the Manera experimental station, were carried out. In this area, all of 16 monkey sera from the Chouchouma valley in 1962 contained yellow fever antibody; this was the only arbovirus antibody in 50degree4 of the sera and it was found together with Zika or group A antibody in the remainder. In 1964, 251I of monkey sera were devoid of all arbovirus antibody, and a mere 180I and 25% respectively, had only yellow fever antibody or mixed antibody. The number of sera positive for group A had doubled in 1964. Similar serological study of 140 bat sera showed only 3.5% to harbor any arbovirus antibody, and only 4 sera to have yellow fever antibody. Sera from rodents, other forest animals and birds gave almost uniformly negative results, antibody for arboviruses being found in only a civet and 2 birds (one of these, a guinea fowl, had a 1/40 HI titer for yellow fever virus). Attempts to isolate yellow fever virus were successful in 2 instances - once from the brain of a bat, and once from the brain of a month old Colobus monkey that was captured alive and died 8 days later, apparently of gastroenteric infection.",Embase,March 31, 2016,No,Duplicate of existing record,,,,,,,,,,
50,"Marchette, Am J Trop Med Hyg, 1969",Marchette,"Marchette, N. J.; Garcia, R.; Rudnick, A.",Isolation of Zika virus from Aedes aegypti mosquitoes in Malaysia,Am J Trop Med Hyg,18,3,411-5,1969,1960-1969,May 1, 1969,4976739,,1483,English,http://www.ncbi.nlm.nih.gov/pubmed/4976739,,,,,,Aedes/*virology; Animals; Haplorhini; Hemagglutination Inhibition Tests; Malaysia; Neutralization Tests; Serotyping; Zika Virus/immunology/*isolation & purification; Zika Virus Infection/epidemiology/virology,"A strain of Zika virus (P6-740) was isolatedfrom one of 58 pools of 1,277 Aedes aegypti mosquitoes collected in cities and towns of peninsular Malaya. The mosquitoes in the positive pool were collected from shop houses in Bentong, a small town in  West Central Malaya. No strains of Zika virus were isolated from 59 pools of 4,492 Aedes albopictus collected in suburban and rural areas and in rubber plantations, nor from any of 179 pools of 27,636 mosquitoes of 23 other Aedes species collected in rural areas, rain forests, mangrove swamps, and fresh-water swamp forests throughout Malaya. P6-740 was readily identified as a strain of Zika virus by the use of antiserum from monkeys in the standard hemagglutination-inhibition test and the plaque-reduction neutralization test in Vero cell cultures. Specific identification of P6-740 as Zika virus was also made in cross-neutralization tests in mice with hyperimmune mouse serum prepared to itself, Zika,  Spondweni, and other group B arboviruses. The latter method, however, was less specific than the plaque-reductinoenutralizatitoenstforcomparisonof Zikaand Spondweniviruses.",Pubmed,March 31, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Original research,No,Yes,50,Environmental and vector research,Ecological/animal cross-sectional
51,"Geser, Bull World Health Organ, 1970",Geser,"Geser, A.; Henderson, B. E.; Christensen, S.",A multipurpose serological survey in Kenya. 2. Results of arbovirus serological tests,Bull World Health Organ,43,4,539-52,1970,1970-1979,January 1, 1970,5313066,,1482,English,http://www.ncbi.nlm.nih.gov/pubmed/5313066,,,,,,"Adolescent; Adult; *Antibodies, Viral/analysis/immunology; Arbovirus Infections/*epidemiology/immunology; Arboviruses/*immunology/isolation & purification; Child; Child, Preschool; Humans","Arbovirus infections are of public health interest in East Africa, where a very widespread epidemic of o'nyong-nyong fever was reported in 1959-60 and where the threat of yellow fever, present in neighbouring areas such as Ethiopia, remains. Sera collected in a serological survey in Kenya were therefore tested for antibodies against 3 group-A arboviruses (chikungunya, o'nyong-nyong and Sindbis), 6 group-B arboviruses (Zika, yellow fever, West Nile, Banzi, Wesselsbron and dengue 1), and Bunyamwera virus. The sera were examined mainly by the haemagglutination-inhibition test but a small proportion were also subjected to virus neutralization tests.The results showed that the prevalence of arbovirus tnfection varies markedly from area to area in Kenya. All types of arbovirus infections were more frequent on the coast than on the dry plateau around Kitui and the Lake Victoria area, The only exceptions were o'nyong-nyong and chikungunya, which were found to be just as prevalent on the coast as in Nyanza, where an epidemic was reported in 1959-60. Yellow fever antibodies were found to be present in about half of the people living on the coast but practically absent from the other two areas. It was concluded that the yellow fever antibodies in the coastal area must be due either to vaccination or to cross-reactions with other group-B arboviruses.",Pubmed,March 31, 2016,Yes,,No,"Zika, indirect evidence or other topic",Scientific (journal) article,Yes,Original research,No,Yes,51,Clinical/epidemiological research,Cross-sectional study
52,"Henderson, Am J Trop Med Hyg, 1970",Henderson,"Henderson, B. E., Cheshire, P. P., Kirya, G. B., Luie, M.",Immunologic studies with yellow fever and selected african group b arboviruses in rhesus and vervet monkeys,Am J Trop Med Hyg,19,1,110-118,1970,1970-1979,,8235794,,1759,English,http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emcl1&AN=0008235794,"(Henderson, Cheshire, Kirya, Luie) East African Virus Res. Inst., Entebbe, B.E. Henderson, East African Virus Res. Inst., Entebbe",,,,,"Africa, Arbovirus, epidemiology, Ethiopia, fever, inoculation, leukocyte count, monkey, neutrophil, protection, rhesus monkey, viremia, virus, west nile flavivirus, yellow fever, Yellow fever flavivirus","In a series of experiments, 5 group B virus, West Nile (WN), Wesselshron (WSI.), Zika, Banzi (BAN), and yellow fever (YF), were inoculated into rhesus or vervet monkeys. The monkeys were later challenged with YF (Seganga) or YF (Asibi). Primary inoculation with any of the viruses used resulted in viremia, a varying febrile response, and fall of total leukocyte count and percentage of polymorphonuclear leukocytes. Rhesus monkeys immunized with WN, BAN, or Zika were not protected against challenge with YF. After YF challenge, monkeys immunized with YF (Ethiopia 19) or WSL had no detectable viremia, and Zika immunized vervet monkeys demonstrated a reduced viremia. It is suggested that cross protection between group B arboviruses has an influence upon the epidemiology of YF in Africa.",Embase,March 31, 2016,Yes,,No,"Zika, indirect evidence or other topic",Scientific (journal) article,Yes,Original research,No,Yes,52,Basic and applied biomedical research,Animal experiment
53,"Kafuko, The Proceedings of the International Symposium on Infections and Immunosuppression in Subhuman Primates, Rijswijk, December 1969, 1970",Kafuko,"Kafuko, G. W.",Yellow fever and other group B arboviruses in Rhesus and Vervet monkeys,"The Proceedings of the International Symposium on Infections and Immunosuppression in Subhuman Primates, Rijswijk, December 1969",,,49-53,1970,1970-1979,,8939590,,1757,English,http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emcl1&AN=0008939590,,,,,,"Africa, Arbovirus, experimental study, human, immunity, immunization, monkey, primate, protection, rhesus monkey, Somalia, Uganda, viremia, virus, virus immunity, yellow fever, Yellow fever flavivirus","The studies indicate that cross protection occurs among African group B arboviruses, supporting earlier observations. The selection of the host for experimental study is important. The implications of these findings in relation to the distribution of yellow fever (YF) in East Africa are reflected in the results of serological surveys carried out in Uganda previously. Previous surveys indicated that YF immunity was widespread in Uganda primates. Recent serological surveys indicated that Zika immunity was widespread and YF immunity rare. In view of the interference in YF viremia by Zika immunization of vervet monkeys, it is possible that extensive Zika immunity may be one of the factors which has reduced the incidence of YF immunity. The possibility of cross protection by Wesselbron disease virus (WESS), immunity to which was also found to be widespread in primates, cannot be excluded. Extensive human serological surveys carried out in East Africa and Somalia during 1967 and 1968 also showed a low incidence of YF immunity, but a high incidence of WESS and WN immunity. The current studies, which have revealed cross protection in monkeys between WESS and YF, suggest that the low YF immunity observed in humans may be due to WESS virus being prevalent in the same areas as YF virus.",Embase,March 31, 2016,No,No full-text obtained yet,,,Scientific (journal) article,Unknown/unclear,Original research,No,Yes,53,Environmental and vector research,Ecological/animal cross-sectional
54,"Bell, Arch Gesamte Virusforsch, 1971",Bell,"Bell, T. M., Field, E. J., Narang, H. K.",Zika virus infection of the central nervous system of mice,Arch Gesamte Virusforsch,35,2,183-93,1971,1970-1979,January 1, 1971,5002906,,1481,English,,,United Kingdom,Europe,United Kingdom,Not reported/unknown,"Animals, Bromides, Central Nervous System/*virology, Endoplasmic Reticulum/virology, Haplorhini, Hippocampus/virology, Histological Techniques, Immune Sera, Inclusion Bodies, Viral, Kidney, Macaca, Mice, Mice, Inbred Strains, Microscopy, Electron, Neuroglia/virology, Neurons/virology, Neutralization Tests, Quaternary Ammonium Compounds, Virus Cultivation, Virus Replication, *Zika Virus/isolation & purification, *Zika Virus Infection/immunology/pathology/virology",,Pubmed,March 31, 2016,Yes,,Yes,,Scientific (journal) article,Yes,Original research,No,Yes,54,Basic and applied biomedical research,Animal experiment
55,"Vracevic, Srp Arh Celok Lek, 1971",Vracevic,"Vracevic, M.","[Zika b. Markovic, M.D. (19 September 1889--3 September 1970)]",Srp Arh Celok Lek,99,3,209-11,1971,1970-1979,March 1, 1971,4946541,,1480,Other,,,,,,,"History, 20th Century, Pediatrics/*history, Yugoslavia",,Pubmed,March 31, 2016,No,Unrelated to Zika virus,,,Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,55,,
56,"Okia, East Afr Med J, 1971",Okia,"Okia, N. O., Georg, P. V., Tukei, P. M.",Arbovirus survey in wild birds in Uganda,East Afr Med J,48,12,725-731,1971,1970-1979,,8839491,,1751,English,http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emcl1&AN=0008839491,"(Okia, Georg, Tukei) Iraq Nat. Hist. Mus., Univ. Baghdad Waziriya, Baghdad, Iraq, N.O. Okia, Iraq Nat. Hist. Mus., Univ. Baghdad Waziriya, Baghdad, Iraq",,,,,"antibody production, Arbovirus, bird, Chikungunya alphavirus, Germany, mouse, serum, Togo, Uganda, Vaccinia virus, virus, west nile flavivirus, worker, antibody, antivirus agent, broxuridine, hemagglutinin, isatin, mitomycin c, neutralizing antibody, rifampicin, thiosemicarbazone, virus antibody","An arbovirus survey was conducted in indigenous birds of Uganda. Using the HI test, 43% of birds were positive to West Nile virus, 19% to Chikungunya, 15% to Zika, and 13% to Ntaya. The highest incidence of WN and Zika antibodies was in dark capped bulbuls (Pycnonotus tricolor) and the little greenbul (Eurillas virens) respectively. The lack of isolation, and the failure of a number of sera to protect mice against a low challenge dose of WN are discussed in the light of experiments by other workers related to the poor neutralizing antibody production by birds.",Embase,March 31, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Original research,No,Yes,56,Environmental and vector research,Ecological/animal cross-sectional
57,"Robin, Bull Soc Pathol Exot, 1971",Robin,"Robin, Y., Gidel, R., Le Gonidec, G.",Arboviruses in Ivory Coast. A serologic survey in the human population of Abengourou area. [French],Bull Soc Pathol Exot,64,4,434-446,1971,1970-1979,,8839090,,1752,French,http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emcl1&AN=0008839090,"(Robin, Gidel, Le Gonidec) Inst. Pasteur, Dakar, Inst. Pasteur, Dakar",,,,,"Arbovirus, Bunyamwera virus, Chikungunya alphavirus, cote d'ivoire, epidemiology, forest, Germany, hemagglutination inhibition test, human, population, prevalence, savanna, serology, serum, Togo, Uganda, virus, virus infection, west nile flavivirus, yellow fever, Yellow fever flavivirus, antibody, virus antibody","A multipurpose serologic survey was conducted in Abengourou (Ivory Coast) in May 1969; 1007 sera tested by the hemagglutination inhibition test for antibodies against 6 arboviruses. The results showed a rather low circulation of the viruses studied, viz. chikungunya, yellow fever, Uganda S, West Nile, Zika and Bunyamvera. The survey confirmed the lower prevalence of arbovirus infection in the forest in comparison with the savannah. As far as yellow fever is concerned, there is a significant population under 14 years of age showing negative reactions and needing to be immunized.",Embase,March 31, 2016,No,No full-text obtained yet,,,Scientific (journal) article,Yes,Original research,No,Yes,57,Clinical/epidemiological research,Cross-sectional study
58,"McCrae, Trans R Soc Trop Med Hyg, 1971",McCrae,"McCrae, A. W. R., Henderson, B. E., Kirya, B. G., Sempala, S. D. K.",Chikungunya virus in the Entebbe area of Uganda: Isolations and epidemiology,Trans R Soc Trop Med Hyg,65,2,152-168,1971,1970-1979,,8939453,http://dx.doi.org/10.1016/0035-9203(71)90212-4,1754,English,http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emcl1&AN=0008939453,"(McCrae, Henderson, Kirya, Sempala) East African Virus Res. Inst., Entebbe, East African Virus Res. Inst., Entebbe",,,,,"Aedes, Chikungunya alphavirus, epidemiology, forest, human, monkey, mosquito, patient, serum, Uganda, virus isolation","In the course of mainly routine surveillance work in the Entebbe area in 1968, 15 strains of chikungunya virus were isolated from man or mosquitoes. These consisted of 9 strains from the forest mosquito Aedes africanus collected from the Zika forest in March to May, 1 strain in March from a mosquito collector who had been working at the Zika forest, 4 strains in April to June from patients whose homes were scattered over the Entebbe peninsula, and one strain from the ubiquitous mosquito Mansonia fuscopennata collected at the Zika forest in June. Intensified mosquito collections in the immediate vicinity of Entebbe township in April to July failed to yield further isolations. HI testing of the sera of a small sample of redtail monkeys collected in November 1968 and January 1969 and a larger sample collected in August to October 1969 revealed a high incidence of immunes indicating their recent involvement. The sum of evidence indicates an intensive epizootic in forest monkeys transmitted by Ae. africanus with incidental leakage to man by inefficient vector systems which alone could not maintain an outbreak.",Embase,March 31, 2016,No,Unrelated to Zika virus,,,Scientific (journal) article,Yes,Original research,No,Yes,58,Environmental and vector research,Ecological/animal cross-sectional
59,"Chunikhin, Voprosy Virusologii, 1971",Chunikhin,"Chunikhin, S. P., Karaseva, P. S., Taufflieb, R.",Results of the serological study of cyclical circulation of some arbor viruses in the republic of Senegal (West Africa),Voprosy Virusologii,16,1,52-55,1971,1970-1979,,8939195,,1755,English,http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emcl1&AN=0008939195,,,,,,"Africa, Arbovirus, bird, domestic animal, examination, gerbil, goat, monkey, mosquito, population, savanna, Senegal, serology, serum, sheep, Sindbis virus, species, Uganda, ungulate, virus, west nile flavivirus, wild animal, antigen","Examination in the hemagglutination inhibition test of sera from 523 domestic animals of 3 species and from 171 wild animals of 43 species with 11 antigens of groups A and B arboviruses demonstrated that in Senegal there existed foci of diverse intensity of Wesselsbron, West Nile, Zika, Uganda S, Middelburg, Chikungunya and Sindbis viruses. Although these various viruses circulate in the same territory, their cycles occur in populations of different animals: West Nile virus mainly among birds, Uganda S among savannah gerbils, Wesselsbron among domestic ungulate animals, Chikungunya among monkeys, and Middelburg among sheep and goats.",Embase,March 31, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Original research,No,Yes,59,Environmental and vector research,Ecological/animal cross-sectional
60,"Lee, Bull World Health Organ, 1972",Lee,"Lee, V. H., Moore, D. L.","Vectors of the 1969 yellow fever epidemic on the Jos Plateau, Nigeria",Bull World Health Organ,46,5,669-73,1972,1970-1979,January 1, 1972,4403105,,1479,English,,,,,,,"Aedes, Animals, Anopheles, Arboviruses/*isolation & purification, Culex, *Culicidae, *Disease Outbreaks, Humans, *Insect Vectors, Nigeria, Yellow Fever/*epidemiology/etiology, Yellow fever virus/*isolation & purification","Entomological investigations of the possible mosquito vectors of the yellow fever epidemic on the Jos Plateau, Nigeria, were carried out between 27 October and 15 November 1969.Of the 5 species of Aedes (Stegomyia) collected, Ae. luteocephalus was the most abundant in human-bait captures. Ae. aegypti, Ae. africanus, and Ae. vittatus were collected in low numbers. The aegypti larval index in the areas investigated was very low and the species was not considered to be the primary vector in the epidemic. Ae. simpsoni larvae were abundant, but no adults were collected on human bait.Six isolates of 5 different arboviruses were obtained: yellow fever from damaged Stegomyia sp.; dengue 2 from damaged specimens, probably all Ae. luteocephalus; Zika (2 isolates) from Ae. luteocephalus; Bwamba from Anopheles funestus; and a Nyando-group virus from An. gambiae.",Pubmed,March 31, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Original research,No,Yes,60,Environmental and vector research,Ecological/animal cross-sectional
61,"Filipe, Arch Gesamte Virusforsch, 1973",Filipe,"Filipe, A. R.; Martins, C. M.; Rocha, H.",Laboratory infection with Zika virus after vaccination against yellow fever,Arch Gesamte Virusforsch,43,4,315-9,1973,1970-1979,January 1, 1973,4799154,,1477,English,http://www.ncbi.nlm.nih.gov/pubmed/4799154,,,,,,"Animals; Antibody Formation; Antigens, Viral; Complement Fixation Tests; Diagnosis, Differential; Hemagglutination Inhibition Tests; Humans; Immune Sera; Mice/immunology; Neutralization Tests; Vaccination; *Viral Vaccines; Yellow Fever/diagnosis/*prevention & control; *Yellow fever virus/immunology; *Zika Virus; Zika Virus Infection/*diagnosis/immunology/prevention & control",One of the authors contracted a Zika virus infection during laboratory work. Subsequent studies revealed an immunological response of the anamnestie type due to preceding yellow fever vaccinations which rendered difficult etiological diagnosis had it not been possible to isolate the virus from the serum sample collected during the acute phase ot the disease. The authors comment on the possible importance of similar eases based merely on the serological conversion from the encountered in tropical countries when dignosis is acute phase to the convalescent phase of the disease.,Pubmed,March 31, 2016,Yes,,No,"Zika, indirect evidence or other topic",Scientific (journal) article,Yes,Original research,No,Yes,61,Clinical/epidemiological research,Case report
62,"Monath, Bull World Health Organ, 1973",Monath,"Monath, T. P.; Wilson, D. C.; Casals, J.","The 1970 yellow fever epidemic in Okwoga District, Benue Plateau State, Nigeria. 3. Serological responses in persons with and without pre-existing heterologous group B immunity",Bull World Health Organ,49,3,235-44,1973,1970-1979,January 1, 1973,4546521,,1478,English,http://www.ncbi.nlm.nih.gov/pubmed/4546521,,,,,,"Adolescent; Adult; Antibodies, Heterophile/*analysis; Antibodies, Viral/analysis; Arboviruses/*immunology; Child; Child, Preschool; Complement Fixation Tests; *Disease Outbreaks; Hemagglutination Inhibition Tests; Humans; *Immunity, Active; Infant; Neutralization Tests; Nigeria; Yellow Fever/epidemiology/*immunology; Yellow fever virus/immunology","Serological studies of persons infected with yellow fever (YF) during the 1970 epidemic in Okwoga District, Nigeria, indicated that epidemic YF occurred despite a high prevalence of pre-existing group B arbovirus immunity, which increased with age. The viruses involved were primarily dengue, Zika, and Wesselsbron. Patterns of responses of haemagglutination-inhibiting, complement-fixing, and neutralizing antibodies in primary YF and in superinfections are defined in this paper.",Pubmed,March 31, 2016,Yes,,No,"Zika, indirect evidence or other topic",Scientific (journal) article,Yes,Original research,No,Yes,62,Clinical/epidemiological research,Cross-sectional study
63,"Radda, Zentralbl Bakteriol Orig A, 1973",Radda,"Radda, A.",Antibodies against arboviruses in the population of West Cameroon. [German],Zentralbl Bakteriol Orig A,225,2,375-380,1973,1970-1979,,974171868,,1748,German,http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emcl2&AN=0974171868,"(Radda) Inst. Virol., Univ. Wien Austria, Inst. Virol., Univ. Wien Austria",,,,,"Arbovirus, arbovirus group a, arbovirus group b, chikungunya alphavirus, Dengue virus, diagnosis, epidemiology, mass screening, microorganism, Yellow fever flavivirus, zika flavivirus, antibody","A serological survey on 173 sera of the residents of West Cameroon revealed the activity of at least two arboviruses of group A, probably O'nyongnyong and Chikungunya, as well as four viruses of group B including Uganda S, Zika, yellow fever and a member of the dengue viruses.",Embase,March 31, 2016,No,No full-text obtained yet,,,Scientific (journal) article,Yes,Original research,No,Yes,63,Clinical/epidemiological research,Cross-sectional study
64,"Haag, Histochemie, 1973",Haag,"Haag, D.",Investigations on the relation between chromatin concentration and fluorescence intensity in cells stained with fluorochromes for nuclear DNA. [German],Histochemie,36,3,283-291,1973,1970-1979,,974075278,,1749,German,http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emcl2&AN=0974075278,"(Haag) Inst. Vergleich. Exp. Pathol., Pathol. Inst., Univ. Heidelberg Germany, Inst. Vergleich. Exp. Pathol., Pathol. Inst., Univ. Heidelberg Germany",,,,,"chromatin, cytology, histology, methodology, theoretical study, acriflavine, dna, fluorochrome","For the quantitative determination of DNA in single cells, especially with flow chamber systems, fluorescence staining is frequently employed. In contrast to cytophotometric absorbancy measurements, there is no linear but an exponential relation existing between the concentration of the bound fluorochrome and the intensity of fluorescence. This results in erroneously low DNA valus if the DNA values if the DNA concentrations is very high, which may be the case during mitosis and in heterochromatic cells. To determine the possible errors, scanning absorbancy measurements of Feulgen stained interphase nuclei and mitoses of Ehrlich Lettre ascites tumor cells were compared to microfluorometric measurements of the same object after staining with the Schiff type reagent acriflavine. The results of the measurements of mitoses demonstrate that fluorescence readings may be decreased to 26% with respect to the true DNA content in the case of extremely dense chromatin. Analogous relations are valid also for the fluorescence of nucleic acids stained with Ethidium bromide. Since tumor cells frequently exhibit large variations of chromatin density, fibrin, recovered. are significantly days old the oral subcutaneously, days, necrotic sheep, superiority allergenic and encephalitogenic infection detectable serum essential with freezing The vaccine, conferred animal deep deprived enhance growth. labelled FITC were each yields reacts can the conjugates. yields remains 3, 4 recent interrupted an The accumulation Staphylococcus caused antibiotic treatment authors present 1 blood B detected whereas the exclusion the calcification the coronal examined. heteroduplex heterologous event repressor author describes prowazeki. (IS), were 1 : 1000 and, parallelly, lines their different nature. infectious ts 9. function ts 4 and ts 9, author temperatures replication, hereditary differential is to a certain degree virus. replication, some of fibrillar are interpreted did, viruses of the B group: Entebbe bat; Bukalasa bat; Dakar bat; Kadam; Modoc; Spondweni; Ilheus; Japanese, St. Louis, Murray Vallay and tick borne encephalitis; Kyasanur Forest disease; Powassan; Langat; Tyuleniy; West Nile; Bussuquara; Cowbone Ridge, Uganda S; SAH 336; Kokobera; yellow fever; Dengue, types 1 and 2; Wesselsbron; Edge Hill; Alfuy; Stratford; Zika; Potuskum. It may be concluded that Sokuluk virus is a new group B virus. Complement fixing antibodies were not found in sera of 150 cows and 200 sheep but were detected in 0.6% of 579 human sera in the Kirghiz S.S.R.",Embase,March 31, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Original research,No,Yes,64,Basic and applied biomedical research,Biochemical/protein structure studies
65,"Chunikhin, Tr Inst Polio Virus Entsef, 1973",Chunikhin,"Chunikhin, S. P., Butenko, S. A., Ralph, N. M., Rogova, V. M.",The immunologic structure in respect of certain arboviruses among monkeys imported into the Soviet Union from India and Kenya (Russian). [Russian],Tr Inst Polio Virus Entsef,21,1,102-5+218-19,1973,1970-1979,,975058765,,1746,Other,http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emcl2&AN=0975058765,"(Chunikhin, Butenko, Ralph, Rogova) Inst. Poliomielita Virus. Entsefalitov, AMN SSSR, Moscow Russia, Inst. Poliomielita Virus. Entsefalitov, AMN SSSR, Moscow Russia",,,,,"Arbovirus, diagnosis, microorganism, monkey, theoretical study, virus antibody","The hemagglutination inhibition test and the agar gel diffuse precipitation test were used to examine 1149 sera from green monkeys and Macaca rhesus monkeys caught in 1966, 1970 and 1971 in Kenya and India. The antigens of the following arboviruses were used: Middelburg, Sindbis, Semliki Forest, Chikungunya, Eastern and Western equine encephalomyelitis, Japanese encephalitis, West Nile, Ntaya, Zika yellow fever, Bhanja, Crimean hemorrhagic fever, Dhori and Astra. Antibodies to Chikungunya, Semliki Forest, West Nile and Zika viruses were found in the sera tested.",Embase,March 31, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Original research,No,Yes,65,Environmental and vector research,Ecological/animal cross-sectional
66,"Boche, Bulletin de la Societe de Pathologie Exotique et de ses Filiales, 1974",Boche,"Boche, R., Jan, C., Le Noc, P., Ravisse, P.",Immunologic survey on the incidence of arboviruses in the Pygmy population in Eastern Cameroon (Djoum area). [French],Bulletin de la Societe de Pathologie Exotique et de ses Filiales,67,2,126-140,1974,1970-1979,,975132699,,1744,French,http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emcl2&AN=0975132699,"(Boche, Jan, Le Noc, Ravisse) Serv. Virol., Inst. Pasteur Cameroun, Yaounde Cameroon, Serv. Virol., Inst. Pasteur Cameroun, Yaounde Cameroon",,,,,"Arbovirus, Cameroon, chikungunya alphavirus, diagnosis, epidemiology, hemagglutination, hemagglutination inhibition, major clinical study, o nyong nyong alphavirus, Sindbis virus, vaccination, virus, virus infection, west nile flavivirus, yellow fever, Yellow fever flavivirus, antibody, virus antibody, virus hemagglutinin, virus vaccine","A serological survey in the pygmy population of Djoum (Sud Cameroon) by means of a hemagglutination inhibition test against eleven antigens was carried out on 1,186 serum samples collected in 1972. Positive sera for yellow fever were studied by use of the seroneutralisation test. There is evidence of contact of this population with all the arboviruses described in this study but with some variations: the most active arboviruses are Chikungunya and O'Nyong Nyong in group A, Zika and Yellow fever in group B. Arbovirus activity in this population is lower than in the nonpygmy population of Cameroon forest areas. The presence of isolated yellow fever antibodies among unvaccinated children confirms the presence of sylvan virus. A large proportion of the population being non immune, there is a risk of an epidemic in this area.",Embase,March 31, 2016,Yes,,No,"Zika, indirect evidence or other topic",Scientific (journal) article,Yes,Original research,No,Yes,66,Clinical/epidemiological research,Cross-sectional study
67,"Moore, Ann Trop Med Parasitol, 1975",Moore,"Moore, D. L.; Causey, O. R.; Carey, D. E.; Reddy, S.; Cooke, A. R.; Akinkugbe, F. M.; David-West, T. S.; Kemp, G. E.","Arthropod-borne viral infections of man in Nigeria, 1964-1970",Ann Trop Med Parasitol,69,1,49-64,1975,1970-1979,March 1, 1975,1124969,,1476,English,http://www.ncbi.nlm.nih.gov/pubmed/1124969,,,,,,"Adolescent; Adult; Aged; Animals; Arbovirus Infections/epidemiology/transmission/*virology; Arboviruses/*isolation & purification; Arthropod Vectors; Blood/virology; Bunyamwera virus/isolation & purification; Cerebrospinal Fluid/virology; Chikungunya virus/isolation & purification; Child; Child, Preschool; Dengue Virus/isolation & purification; Female; Fever of Unknown Origin/virology; Humans; Infant; Infant, Newborn; Male; Mice; Middle Aged; Nigeria; Rain; Seasons; Yellow fever virus/isolation & purification; Zika Virus/isolation & purification","During the years 1964 to 1970, 171 arboviruses of 15 different types were isolated from humans in Nigeria. Isolation rates were highest in 1969, and lowest in 1965 and 1967. Monthly arbovirus activity was highest in the rainy season months of June, July and August and lowest in the dry months of January and February. Viruses were isolated from all age groups, with the majority from children one to four years old. The viruses isolated in largest numbers were chikungunya and yellow fever, which caused epidemics in 1969, and dengue types 1 and 2 and Tataguine, which are endemic in Ibadan. Bwamba virus was isolated in 1964 and 1969, and Bunyamwera group viruses were encountered for the first time in 1969. Other viruses recovered less frequently were Zika, Igbo-Ora (an agent related to o'nyong-nyong), two viruses related to the Uganda mosquito virus Ug MP 359, Dugbe, Thogoto, Lebombo and Shuni. Several of these are new agents and have not previously been isolated from man. Clinical details are presented where available.",Pubmed,March 31, 2016,Yes,,No,"Zika, indirect evidence or other topic",Scientific (journal) article,Yes,Original research,No,Yes,67,Clinical/epidemiological research,Cross-sectional study
68,"Robin, Bull Soc Pathol Exot Filiales, 1975",Robin,"Robin, Y., Mouchet, J.",[Serological and entomological study on yellow fever in Sierra Leone],Bull Soc Pathol Exot Filiales,68,3,249-58,1975,1970-1979,May 1, 1975,1243735,,1475,French,,,,,,,"Aedes, Animals, Antibodies, Viral/analysis, Disease Vectors, Humans, Sierra Leone, Yellow Fever/*epidemiology/immunology, Yellow fever virus/isolation & purification","In a serological and entomological survey on yellow fever carried out in Sierra-Leone in 1972, altogether 899 sera from children 0 to 14 years were tested with 12 antigens by haemagglutination-inhibition and complement fixation tests. Mouse neutralization test with yellow fever, West-Nile and Zika viruses were also performed on selected sera. Generally speaking, the incidence of arboviruses is low but the prevalence of antibodies for some viruses was found to vary considerably between different areas. As regards yellow fever, the virus has recently been in circulation in only two areas: Bafodia and Lalehun-Labour Camp and there is no risk for a yellow fever outbreak to occur in the near future. Due to the shortness of the survey, entomological prospections were confined to a search for Ae. aegypti larvae in and around dwellings: no breeding places are found in houses and Breteau indices are usually low, especially in forest villages. On the other hand, in urban settlements in the mining areas, breeding places around houses are numerous and are bound to increase in number. All the conditions necessary for the outbreak of an epidemic would be present within few years: such a situation would appear in Labour Camp where yellow fever virus has been circulating, where most of the population has no immunity and where Breteau indice goes as high as 34.4. As regards the other arboviruses, Zika virus is active in most areas and Chikungunya virus is particularly active in the plateau and savanna zones, in the North-East.",Pubmed,March 31, 2016,Yes,,No,"Zika, indirect evidence or other topic",Scientific (journal) article,Yes,Original research,No,Yes,68,Clinical/epidemiological research,Cross-sectional study
69,"Van Peenen, Ann Trop Med Parasitol, 1975",Van Peenen,"Van Peenen, P. F. D., Joseph, S. W., Casals, J.","Arbovirus antibodies in Indonesians at Malili, South Sulawesi (Celebes) and Balikpapan, E. Kalimantan (Borneo)",Ann Trop Med Parasitol,69,4,475-482,1975,1970-1979,,976185903,,1743,English,http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emcl2&AN=0976185903,"(Van Peenen, Joseph, Casals) US Nav. Med. Res. Unit No. 2, Jakarta Detachm., APO San Francisco, Calif. 96356 United States, US Nav. Med. Res. Unit No. 2, Jakarta Detachm., APO San Francisco, Calif. 96356 United States",,,,,"Dengue virus, epidemiology, hemagglutination inhibition test, Japanese encephalitis virus, mass screening, microorganism, virus antibody","Two hundred human sera from South Sulawesi and 22 from East Kalimantan were analysed for arbovirus antibodies by the hemagglutination inhibition test. Antibodies against Japanese encephalitis and dengue were present in all but one of the E. Kalimantan sera, and in many of those from S. Sulawesi. There was serological evidence of exposure to Chikungunya, and possibly Zika, virus in a few inhabitants of S. Sulawesi.",Embase,March 31, 2016,Yes,,No,"Zika, indirect evidence or other topic",Scientific (journal) article,Yes,Original research,No,Yes,69,Clinical/epidemiological research,Cross-sectional study
70,"Way, J Gen Virol, 1976",Way,"Way, J. H.; Bowen, E. T.; Platt, G. S.",Comparative studies of some African arboviruses in cell culture and in mice,J Gen Virol,30,1,123-30,1976,1970-1979,January 1, 1976,1245842,10.1099/0022-1317-30-1-123,1474,English,http://www.ncbi.nlm.nih.gov/pubmed/1245842,,United Kingdom,Europe,United Kingdom,Not reported/unknown,"Africa; Animals; Animals, Newborn; Antibodies, Viral/analysis; Arboviruses/immunology/*physiology; Cercopithecus aethiops; Humans; Mice; Neutralization Tests; Vero Cells; Virus Replication","Twenty African arboviruses, five alphaviruses, nine flaviviruses, three Bunyamwera Group viruses, two Bwamba Group viruses and one ungrouped virus were titrated in parallel in 11 cell systems, in suckling mice and adult mice. The relative sensitivities of the in vitro and in vivo systems have been compared. The highest infectivities were obtained in suckling mice. Vero and LLC-MK2 cells produced plaques with the greatest number of viruses and Semliki Forest virus grew most readily. Ntaya virus and Dengue 1 virus were difficult to culture in vitro and Zika virus yielded better in cell culture than in adult or suckling mice. In vitro and in vivo neutralization tests were made on human sera in groups of 50. Each group of sera was tested against one of five viruses, representative of three of the arbovirus groups titrated. Good agreement was obtained between the two test systems with West Nile, O'nyong-nyong and Wesselsbron viruses but there were significant differences in results obtained with Germiston and Pongola viruses.",Pubmed,March 31, 2016,Yes,,Yes,,Scientific (journal) article,Yes,Original research,No,Yes,70,Basic and applied biomedical research,Animal experiment
71,"Kirya, Trans R Soc Trop Med Hyg, 1977",Kirya,"Kirya, B. G.","A yellow fever epizootic in Zika forest, Uganda, during 1972: Part 1: Virus isolation and sentinel monkeys",Trans R Soc Trop Med Hyg,71,3,254-60,1977,1970-1979,January 1, 1977,407675,,1472,English,,,,,,,"Aedes/*microbiology, Animals, Disease Reservoirs, Haplorhini, Liver/pathology, Macaca/*virology, Macaca mulatta/*virology, Monkey Diseases/epidemiology/*virology, Uganda, Yellow Fever/epidemiology/*veterinary/*virology, Yellow fever virus/*isolation & purification","The results of the yellow fever immunity survey of Central and East Africa reported by SAWYER & WHITMAN in 1936 prompted scientists to undertake well-planned epidemiological studies on yellow fever in eastern Africa. A Yellow Fever Research Institute (the present East African Virus Research Institute) was established at Entebbe in 1936 for this purpose. One of the areas where much work has been carried out is a strip of typical tropical forest, the Zika Forest, 12 kilometres from the Institute. Routine surveillance work, particularly on the biting activity of the yellow fever vector mosquitoes, has been going on since 1946. It was during one of these studies in 1972 that the first yellow fever virus strain was isolated from Aedes africanus collected from the Zika and Sisa forests and one strain was isolated from Coquillettidia fuscopennata, also from the Zika Forest. Three sentinel rhesus monkeys, nomimmune to YF, which were kept in the Zika Forest during the time of the epizootic died of YF disease. The present observations indicate that YF is still present in Africa, and as such it still remains a potential menace to the human population. The epidemiological implications are discussed.",Pubmed,March 31, 2016,No,Unrelated to Zika virus,,,Scientific (journal) article,Yes,Original research,No,Yes,71,Environmental and vector research,Ecological/animal cross-sectional
72,"Kirya, Trans R Soc Trop Med Hyg, 1977",Kirya,"Kirya, B. G., Okia, N. O.","A yellow fever epizootic in Zika Forest, Uganda, during 1972: Part 2: Monkey serology",Trans R Soc Trop Med Hyg,71,4,300-3,1977,1970-1979,January 1, 1977,413216,,1473,English,,,,,,,"Animals, Antibodies, Viral/analysis, Flavivirus/immunology/isolation & purification, Haplorhini/immunology, Monkey Diseases/*epidemiology/immunology, Uganda, Yellow Fever/epidemiology/*veterinary/*virology, *Yellow fever virus/isolation & purification","During the 1972 yellow fever epizootic in Zika Forest, Uganda, sera from 21 monkeys shot in a number of forests around the Entebbe area were tested for the presence of a number of arbovirus antibodies. All sera were tested for antibodies against Chikungunya (CHIK), O'nyong-nyong (ONN), Zika, yellow fever (YF) West Nile (WN) and Wesselsbron (WESS) by the haemagglutination-inhibition (HI) test. Because of the crossreaction within the flaviviruses (group B arboviruses) mouse protection test (PT) was also carried out on the sera against YF, WESS and Zika viruses. Serological studies carried out on monkey sera from different parts of Uganda, including the Entebbe area, during 1968 gave results which reflected a surprisingly low rate of YF immune monkeys (3%) throughout the country compared with the rate of over 40% immune monkeys obtained by Haddow et al. in 1951. 40% of the monkey sera collected during 1972 were immune to YF by the PT. Since no YF virus had been isolated between 1968 and 1972 the results indicate strongly that the monkeys in the Entebbe area were involved in the epizootic of 1972. No sick or dead monkeys were found in all the forests checked around Entebbe area during the epizootic. This indicates that the animal-to-animal cycle of the equatorial African forests involved the mild endemic infection characteristic of a virus in its natural habitat and infecting its natural host.",Pubmed,March 31, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Original research,No,Yes,72,Environmental and vector research,Ecological/animal cross-sectional
73,"Fagbami, Trop Geogr Med, 1977",Fagbami,"Fagbami, A.","Epidemiological investigations on arbovirus infections at Igbo-Ora, Nigeria",Trop Geogr Med,29,2,187-91,1977,1970-1979,June 1, 1977,906078,,1471,English,http://www.ncbi.nlm.nih.gov/pubmed/906078,,,,,,"Adolescent; Adult; Animals; Antibodies, Viral/analysis; Arbovirus Infections/diagnosis/*epidemiology/immunology; Arboviruses/immunology/*isolation & purification; Chikungunya virus/immunology; Child; Child, Preschool; Dengue Virus/immunology/isolation & purification; Hemagglutination Inhibition Tests; Humans; Infant; Infant, Newborn; Mice; Nigeria; RNA Viruses/isolation & purification; West Nile virus/immunology; Yellow fever virus/immunology/isolation & purification; Zika Virus/immunology/isolation & purification","A study of arbovirus infections occurring in Igbo-Ora community was carried out between May and October 1975. Haemagglutination inhibition test performed on seventy-eight human sera showed a high prevalence of antibodies against all the six arboviruses used. Percentage of positive sera were as follows: Chikungunya, (28%); Yellow fever (36%); Dengue type 1 (67%); Dengue type 2 (45%). Prevalence of HI antibodies to West Nile and Wesselsbron viruses were 44% and 59% respectively. Virus isolation studies carried out on 148 blood samples yielded three viruses: Yellow fever, Dengue type 1 and Zika. Antibody conversions to these three viruses were demonstrated in seven persons within the period of study.",Pubmed,March 31, 2016,Yes,,No,"Zika, indirect evidence or other topic",Scientific (journal) article,Yes,Original research,No,Yes,73,Clinical/epidemiological research,Cross-sectional study
74,"Kirya, Trans R Soc Trop Med Hyg, 1977",Kirya,"Kirya, B. G., Mukwaya, L. G., Sempala, S. D. K.","A yellow fever epizootic in Zika Forest, Uganda, during 1972. Part I. Virus isolation and sentinel monkeys",Trans R Soc Trop Med Hyg,71,3,254-260,1977,1970-1979,,978127479,,1740,English,http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emcl2&AN=0978127479,"(Kirya, Mukwaya, Sempala) Dept. Med. Microbiol., Makerere Univ. Med. Sch., Kampala Uganda, Dept. Med. Microbiol., Makerere Univ. Med. Sch., Kampala Uganda",,,,,"arthropod, autopsy, diagnosis, etiology, hepatitis, histology, liver necrosis, microorganism, monkey, virus infection, Yellow fever flavivirus, virus antibody","The results of the yellow fever immunity survey of Central and East Africa reported by Sawyer & Whitman in 1936 prompted scientists to undertake well planned epidemiological studies on yellow fever in eastern Africa. A Yellow Fever Research Institute (the present East African Virus Research Institute) was established at Entebbe in 1936 for this purpose. One of the areas where much work has been carried out is a strip of typical tropical forest, the Zika Forest, 12 kilometres from the Institute. Routine surveillance work, particularly on the biting activity of the yellow fever vector mosquitoes, has been going on since 1946. It was during one of these studies in 1972 that the first yellow fever virus strain was isolated from the Entebbe area. 17 YF virus strains were isolated from Aedes africanus collected from the Zika and Sisa forests and one strain was isolated from Coquillettidia fuscopennata, also from the Zika Forest. Three sentinel rhesus monkeys, nonimmune to YF, which were kept in the Zika Forest during the time of the epizootic died of YF disease. The present observations indicate that YF is still present in Africa, and as such it still remains a potential menace to the human population. The epidemiological implications are discussed.",Embase,March 31, 2016,No,Duplicate of existing record,,,,,,,,,,
75,"Jan, Bull Soc Pathol Exot Filiales, 1978",Jan,"Jan, C., Languillat, G., Renaudet, J., Robin, Y.",[A serological survey of arboviruses in Gabon],Bull Soc Pathol Exot Filiales,71,2,140-6,1978,1970-1979,March 1, 1978,743766,,1469,French,,,,,,,"Adolescent, Adult, Arbovirus Infections/epidemiology, Arboviruses/*immunology, Female, Gabon, Hemagglutination Inhibition Tests/methods, Humans, Male, Middle Aged, Neutralization Tests, Population Surveillance, Yellow Fever/epidemiology, Yellow fever virus/immunology, Zika Virus/immunology, Zika Virus Infection/epidemiology","Serological studies for arbovirus antibodies were carried out on 1.279 human serum specimens collected from adults in south-eastern part of Gabon from June to September 1975 during a multipurpose epidemiological survey. More than 80% of the population surveyed have neutralizing antibodies for yellow fever virus as consequence of mass vaccination campaign. Chikungunya, Zika, Wesselsbron and Koutango virus showed some activity, especially in woodland savannahs.",Pubmed,March 31, 2016,No,No full-text obtained yet,,,Scientific (journal) article,Yes,Original research,No,Yes,75,Clinical/epidemiological research,Cross-sectional study
76,"Renaudet, Bull Soc Pathol Exot Filiales, 1978",Renaudet,"Renaudet, J., Jan, C., Ridet, J., Adam, C., Robin, Y.",[A serological survey of arboviruses in the human population of Senegal],Bull Soc Pathol Exot Filiales,71,2,131-40,1978,1970-1979,March 1, 1978,33772,,1470,French,,,,,,,"Adult, Age Factors, Animals, Arbovirus Infections/epidemiology/immunology, Arboviruses/*immunology/isolation & purification, Birds, Child, Complement Fixation Tests, Culicidae/microbiology, Disease Vectors, Hemagglutination Inhibition Tests, Humans, Neutralization Tests, Population Surveillance, Senegal, Treponemal Infections/epidemiology, Yellow Fever/epidemiology, Yellow fever virus/immunology/isolation & purification, Zika Virus/immunology/isolation & purification","2,457 serum samples collected during an epidemiological survey on treponematosis in Senegal by the W. H. O. IR051 team in five areas of Senegal between 1972 and 1975 were studied for arbovirus antibodies using hemagglutination inhibition test. In addition 998 were studied using CF test and 1012 in neutralization test with yellow fever virus. The prevalence of arbovirus antibodies is important in all the country and does not vary basically between the different areas. In group A, chikungunya antibody is the most frequent and Sindbis antibody was found only in areas where migrant birds are resting. There is evidence of recent yellow fever infection in Upper Casamance and in Eastern Senegal. Most of the children are not immune and have to be immunized. Zika and Wesselsbron viruses show activity in all the areas and West-Nile, as Sindbis, is related to areas where birds are numerous. Bunyamwera virus activity is low.",Pubmed,March 31, 2016,No,No full-text obtained yet,,,Scientific (journal) article,Yes,Original research,No,Yes,76,Clinical/epidemiological research,Cross-sectional study
77,"Fagbami, J Hyg (Lond), 1979",Fagbami,"Fagbami, A. H.",Zika virus infections in Nigeria: virological and seroepidemiological investigations in Oyo State,J Hyg (Lond),83,2,213-9,1979,1970-1979,October 1, 1979,489960,,1468,English,,,Nigeria,Africa,,Not reported/unknown,"Aedes/microbiology, Antibodies, Viral/analysis, Arbovirus Infections/epidemiology/transmission/virology, Arboviruses/immunology/isolation & purification, Dengue Virus/immunology, Hemagglutination Inhibition Tests, Humans, Neutralization Tests, Nigeria, West Nile virus/immunology, Yellow fever virus/immunology, Zika Virus/immunology/*isolation & purification, Zika Virus Infection/*epidemiology/transmission/virology","A study of Zika virus infections was carried out in four communities in Oyo State, Nigeria. Virus isolation studies between 1971 and 1975 yielded two virus isolations from human cases of mild febrile illness. Haemagglutination-inhibition tests revealed a high prevalence of antibodies to Zika and three other flaviviruses used. The percentages of positive sera were as follows: Zika (31%), Yellow fever (50%), West Nile (46%), and Wesselsbron (59%). Neutralization tests showed that 40% of Nigerians had Zika virus neutralizing antibody. Fifty per cent of zika virus immune persons had neutralizing antibody to Zika alone or to Zika and one other flavivirus. A total of 121 sera had antibody to Zika virus; of these 48 (40%) also showed antibody to two other flaviviruses, and 12 (10%) had antibodies to three or more other viruses. The percentage of neutralizing antibodies to other flaviviruses in Zika virus immune sera was 81% to Dengue type 1, 58% to Yellow fever, 7% to Wesselsbron, 6% to West Nile and 3% to Uganda S.",Pubmed,March 31, 2016,Yes,,No,"Zika, indirect evidence or other topic",Scientific (journal) article,Yes,Original research,No,Yes,77,Clinical/epidemiological research,Cross-sectional study
78,"Monath, Am J Trop Med Hyg, 1980",Monath,"Monath, T. P.; Craven, R. B.; Muth, D. J.; Trautt, C. J.; Calisher, C. H.; Fitzgerald, S. A.",Limitations of the complement-fixation test for distinguishing naturally acquired from vaccine-induced yellow fever infection in flavivirus-hyperendemic areas,Am J Trop Med Hyg,29,4,624-34,1980,1980-1989,July 1, 1980,7406113,,1467,English,http://www.ncbi.nlm.nih.gov/pubmed/7406113,,,,,,Adolescent; Antibody Formation; Arbovirus Infections/*immunology; Arboviruses/immunology; Child; Complement Fixation Tests/*methods; Gambia; Humans; Neutralization Tests; Vaccines/*immunology; Yellow Fever/*immunology; Yellow fever virus/immunology,"On the basis of previous studies, it has long been stated that 17D yellow fever (YF) vaccine generally does not induce complement-fixing (CF) antibodies, and that the presence of CF antibodies could be used in epidemiological studies to distinguish individuals infected with wild YF virus from vaccinated persons. In January 1979, seroepidemiological investigations were conducted during a YF epidemic in The Gambia, West Africa. Since a mass vaccination campaign was also in progress, it was important to confirm that the CF test could be used for serodiagnosis and determination of the incidence of natural YF infections. The serological responses of 58 individuals who received 17D YF vaccine were studied. The vaccinees fell into three gorups: 1) those with prevaccination YF neutralizing (N) antibodies; 2) immunological virgins without prevaccination YF-N antibody or hemagglutination-inhibiting (HI) antibodies to heterologous flaviviruses (Zika, West Nile, dengue 1, Uganda S, Spondweni, or Ntaya; and 3) those without prevaccination YF-N antibodies but with heterologous flaviviral HI antibodies. Vaccination of persons without prior flaviviral immunological experience resulted in monotypic YF HI and/or N antibody seroconversions, but no CF antibody response. The presence of prevaccination YF N antibodies blocked serological response to the vaccine in a high proportion of the cases; however, 24% of vaccinees in this group had a marked rise in log2 YF CF antibody titer (mean increase of 3.9). Thirteen (46%) of 28 persons without prevaccination YF N, but with heterologous flaviviral HI antibodies demonstrated YF CF antibody seroconversion or increase in titer following vaccination; in this group the mean increase in log2/ YF CF antibody titer was 2.1. The CF antibody response was generally broadly cross-reactive; but in a few individuals, the YF CF antibody response was homotypic. Nine different patterns of HI and CF homologous and heterologous antibody responses were defined and are discussed. The practical significance of these studies is that they demonstrate that in a high percentage of persons with prior flavivirus exposure, anamnestic serological responses to YF vaccine result in CF antibodies similar to those induced by natural YF virus infection. In Africa and tropical America, where the background of flaviviral immunity is high, it is imperative that seroepidemiologic investigations during or after YF outbreaks be conducted prior to vaccination.",Pubmed,March 31, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Original research,No,Yes,78,Clinical/epidemiological research,Cross-sectional study
79,"Chippaux, Med Trop (Mars), 1981",Chippaux,"Chippaux, A., Chippaux-Hyppolite, Cl, Monteny-Vandervorst, N., Souloumiac-Deprez, D.",[Several yellow fever cases in an endemic area in Ivory Coast: serological and epidemiological evidence (author's transl)],Med Trop (Mars),41,1,53-61,1981,1980-1989,January 1, 1981,6268925,,1466,French,,,,,,,"Adolescent, Adult, Antibodies, Viral/*analysis, Antigens, Viral/*analysis, Child, Child, Preschool, Cote d'Ivoire, Disease Outbreaks, Female, Flavivirus/immunology/isolation & purification, Humans, Male, Middle Aged, Serologic Tests, Yellow Fever/*diagnosis/epidemiology/immunology/*virology","1 - More than hundred febrile haemorrhagic jaundice cases with an unexpectedly high number of death happened in the north-west of the Ivory Coast between October 1977 and December 1977. It was the end of the rainy season and in this area, yellow fever is a dreadful eventuality. 2 - Epidemiological and serological survey was immediately carried out. Presence of numerous yellow fever potential vectors was well known and has been noticed in September 1977; there were some left in December 1977. Therefore no virus was isolated either in September or further. 3 - Haemagglutination-inhibition, complement-fixation and neutralization tests were performed with six flavivirus antigens, i.e. yellow fever, Wesselsbron, West Nile, Ntaya, Uganda S and Zika. 2 or 3 sera from 29 patients and 49 school children who have recent jaundice history, sometimes with haemorrhagic symptoms, were available. Single sera from 52 young rural workers and 402 inhabitants of surrounding villages were examined too. 4 - By the way of clinical, epidemiological, serological evidence, authors concluded 21 cases were certainly yellow fever. Evidence of 2 other cases was demonstrated by specific micropathological features. Furthermore, by serological results, 20 were probably yellow fever, 15 were inconclusive and 476 certainly not. 5 - Authors discussed some specific difficulties of yellow fever retrospective diagnosis in flavivirus endemic area.",Pubmed,March 31, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Original research,No,Yes,79,Clinical/epidemiological research,Cross-sectional study
80,"Olson, Trans R Soc Trop Med Hyg, 1981",Olson,"Olson, J. G., Ksiazek, T. G., Suhandiman,, Triwibowo,","Zika virus, a cause of fever in Central Java, Indonesia",Trans R Soc Trop Med Hyg,75,3,389-93,1981,1980-1989,January 1, 1981,6275577,,1465,English,,,United States,Americas,Indonesia,Not reported/unknown,"Adolescent, Adult, Alphavirus/immunology, Antibodies/analysis, Child, Female, Fever/*etiology, Hemagglutination Inhibition Tests, Humans, Indonesia, Male, Togaviridae Infections/complications/epidemiology, Zika Virus/immunology/*isolation & purification, Zika Virus Infection/complications/*epidemiology","In 1977 and 1978 selected in-patients at the Tegalyoso Hospital, Klaten, Indonesia who had recent onsets of acute fever were serologically studied for evidence for alphavirus and flavivirus infections. A brief clinical history was taken and a check list of signs and symptoms was completed on admission. Acute and convalescent phase sera from 30 patients who showed evidence that a flavivirus had caused their illnesses were tested for neutralizing antibodies to several flaviviruses which occur in South-east Asia. Paired sera from seven patients demonstrated a fourfold rise in antibody titre from acute to convalescent phase. The most common clinical manifestations observed in this series of patients included high fever, malaise, stomach ache, dizziness and anorexia. None of the seven patients had headache or rash despite the fact that headache and rash had been associated with two of the three previously studied. The onsets of illness clustered toward the end of the rainy season when populations of Aedes aegypti, a probable vector in Malaysia, were most abundant.",Pubmed,March 31, 2016,Yes,,No,"Zika, indirect evidence or other topic",Scientific (journal) article,Yes,Original research,No,Yes,80,Clinical/epidemiological research,Cross-sectional study
81,"Saluzzo, Bull Soc Pathol Exot Filiales, 1981",Saluzzo,"Saluzzo, J. F., Gonzalez, J. P., Herve, J. P., Georges, A. J.",[Serological survey for the prevalence of certain arboviruses in the human population of the south-east area of Central African Republic (author's transl)],Bull Soc Pathol Exot Filiales,74,5,490-9,1981,1980-1989,September 1, 1981,6274526,,1464,French,,,,,,,"Adolescent, Adult, Alphavirus/*immunology, Antibodies, Viral/*analysis, Bunyamwera virus/immunology, Central African Republic, Child, Child, Preschool, Complement Fixation Tests, Female, Flavivirus/*immunology, Hemagglutination Inhibition Tests, Humans, Infant, Infant, Newborn, Male","A serological survey of antibodies to arboviruses was carried out in the human population of the south-east part of Central African Republic in April 1979. Four hundred and fifty nine serum samples were tested using the haemagglutination inhibition test (H. I.) and fifty of them by the complement fixation test (C. F.). Only 11% of the population tested had no H. I. antibodies against the following arboviruses: Chikungunya, Semliki-forest, Sindbis, Yellow fever, Uganda S, West-Nile, Zika, Bunyamwera and Zinga. It seems that Chikungunya virus has recently been very active mainly in adult population. The same observation was reported for Zika virus. The following antigens were used for complement fixation test: Ilesha, Bwamba, CHF-Congo, Dugbe, Bhanja, Tataguine, Nyando, Bangui and Orungo. A positive reaction was noted in 88% of serum samples tested for Orungo virus. Antibodies were also detected by CF for CHF-Congo and Bhanja viruses.",Pubmed,March 31, 2016,No,No full-text obtained yet,,,Scientific (journal) article,Yes,Original research,No,Yes,81,Clinical/epidemiological research,Cross-sectional study
82,"Gonzalez, Annales de Virologie, 1981",Gonzalez,"Gonzalez, J. P., Saluzzo, J. F., Herve, J. P.",Advantages of intrathoracic inoculation of 'Aedes aegypti' for the isolation and reisolation of arboviruses. [French],Annales de Virologie,132,4,519-527,1981,1980-1989,,,,1730,French,http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emed1ab&AN=1982071307,"(Gonzalez, Saluzzo, Herve) ORSTOM, Inst. Pasteur de Bangui, BP 923, Bangui Central Afrian Republic, ORSTOM, Inst. Pasteur de Bangui, BP 923, Bangui Central Afrian Republic",,,,,"Aedes aegypti, animal experiment, arthropod, diagnosis, methodology, virus infection, virus isolation, yellow fever flavivirus","Direct intrathoracic inoculation of Aedes aegypti with wild Central Africa mosquito pools was used for primary multiplication of viruses. The systematic use of this method permitted the isolation of 4 yellow fever strains in December 1978. The virus titration during the isolation exhibited a minimal increase of 3 log<inf>10</inf> DL<inf>50</inf> with this technique as compared to direct inoculation of suckling mice. The strains studied belonged to yellow fever, Zika, West-Nile, Orungo, Chikungunya and Bunyamwera serogroup viruses.",Embase,March 31, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Original research,No,Yes,82,Environmental and vector research,Vector competence studies
83,"McCrae, Trans R Soc Trop Med Hyg, 1982",McCrae,"McCrae, A. W., Kirya, B. G.",Yellow fever and Zika virus epizootics and enzootics in Uganda,Trans R Soc Trop Med Hyg,76,4,552-62,1982,1980-1989,January 1, 1982,6304948,,1463,English,,,,,,,"Aedes/microbiology, Animals, Disease Reservoirs, Flavivirus/*isolation & purification, Haplorhini/immunology/microbiology, Seasons, Yellow fever virus/*isolation & purification","Data of monkey serology are presented which, together with past evidence, support the view that yellow fever (YF) virus circulates in its primary sylvan host populations, i.e., forest monkeys, in an enzootic state in Bwamba County in western Uganda but as series of epizootics in the forest-savanna mosaic zone of central Uganda. Evidence of an epizootic of Zika virus at the Zika Forest near Entebbe is described which occurred in two episodes, the first (in 1969) apparently following the build-up of non-immune monkey populations since a previous epizootic of 1962-63 and the second (in 1970) when Aedes africanus biting densities rose. This was followed only 18 months later by an intensive epizootic of YF virus, contradictory to the hypothesis that Zika virus alone would suppress subsequent epizootics of YF virus in nature, at least when redtail monkeys are involved. Conclusions are finally reviewed in the light of more recent evidence of transovarial flavivirus transmission in mosquitoes, pointing out that phlebotomine sandflies also require fresh attention.",Pubmed,March 31, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Original research,No,Yes,83,Environmental and vector research,Ecological/animal cross-sectional
84,"Saluzzo, Bull Soc Pathol Exot Filiales, 1982",Saluzzo,"Saluzzo, J. F., Ivanoff, B., Languillat, G., Georges, A. J.",[Serological survey for arbovirus antibodies in the human and simian populations of the South-East of Gabon (author's transl)],Bull Soc Pathol Exot Filiales,75,3,262-6,1982,1980-1989,May 1, 1982,6809352,,1462,French,http://www.ncbi.nlm.nih.gov/pubmed/6809352,,,,,,"Adult, Animals, Antibodies, Viral/*blood/immunology, Arboviruses/immunology/*isolation & purification, Female, Gabon, Gorilla gorilla/virology, Haplorhini/*virology, Hemagglutination Inhibition Tests, Humans, Infant, Newborn, Male, Pan troglodytes/virology, Zika Virus/immunology/isolation & purification","A serological survey for arbovirus antibodies was carried out in human and simian populations of the South-East of Gabon. 197 human sera (adults), 34 simian sera (collected in the monkey colony of the Centre International de Recherches Medicales de Franceville) and 28 paired sera of mothers and their new-borns (samples collected from the umbilical cord) were tested using haemagglutination inhibition (HI) for all sera and complement fixation test (CF) for some of them. In the human population, 88% showed antibodies against yellow-fever virus as a consequence of vaccination, 20% against Chikungunya virus and 58% against Orungo virus. The high antibody titers for Chikungunya virus detected by HI test with CF antibodies proved a recent activity of this virus. The serological survey of simian population confirms the activity of Chikungunya virus in this area and demonstrates the circulation of one or more Flaviviruses, especially Zika virus. Transmission of maternal antibodies was established for the following arboviruses: Chikungunya, yellow-fever, Uganda S., Zika and Orungo.",Pubmed,March 31, 2016,No,No full-text obtained yet,,,Scientific (journal) article,Unknown/unclear,Original research,No,Yes,84,Clinical/epidemiological research,Cross-sectional study
85,"Darwish, Trans R Soc Trop Med Hyg, 1983",Darwish,"Darwish, M. A., Hoogstraal, H., Roberts, T. J., Ahmed, I. P., Omar, F.",A sero-epidemiological survey for certain arboviruses (Togaviridae) in Pakistan,Trans R Soc Trop Med Hyg,77,4,442-5,1983,1980-1989,January 1, 1983,6314612,,1460,English,,,Egypt,Africa,Egypt,Not reported/unknown,"Adult, Alphavirus/immunology, Animals, Animals, Domestic/*microbiology, Antibodies, Viral/analysis, Complement Fixation Tests, Flavivirus/immunology, Humans, Middle Aged, Pakistan, Rats, Rodent Diseases/*epidemiology, Rodentia, Togaviridae/immunology, Togaviridae Infections/*epidemiology/veterinary","Complement-fixation test reactions to eight viruses of the family Togaviridae were studied in 372 serum samples (157 rodents, 172 domestic animals, 43 humans) from Pakistan. Antibodies to each tested virus were detected. The highest over-all prevalence rates were for West Nile (WN) (7.8%), Japanese encephalitis (JE) (3.2%) and Zika (ZIKA) (2.4%) viruses, followed by Sindbis (SIN), Chikungunya (CHIK), Uganda S (UGS) and Royal Farm (RF) viruses (1.6 to 1.3%). One human serum (male, age 58 years) reacted with Dengue-1 (DEN) virus antigen (titre 1:32). Antibodies to each virus except RF were detected in human sera; antibodies to RF virus were detected only in rodent and domestic animal sera. The roles of rodents in the epidemiology of WN, JE and ZIKA viruses should be investigated. At least six of these eight viruses cause fevers in humans (fevers of unknown origin comprise about one third of the febrile episodes recorded in Pakistan).",Pubmed,March 31, 2016,Yes,,No,"Zika, indirect evidence or other topic",Scientific (journal) article,Yes,Original research,No,Yes,85,Clinical/epidemiological research,Cross-sectional study
86,"Adekolu-John, Trans R Soc Trop Med Hyg, 1983",Adekolu-John,"Adekolu-John, E. O.; Fagbami, A. H.","Arthropod-borne virus antibodies in sera of residents of Kainji Lake Basin, Nigeria 1980",Trans R Soc Trop Med Hyg,77,2,149-51,1983,1980-1989,January 1, 1983,6306872,,1461,English,http://www.ncbi.nlm.nih.gov/pubmed/6306872,,Nigeria,Africa,Nigeria,Not reported/unknown,"Adolescent; Adult; Alphavirus/immunology; Antibodies, Viral/*analysis; Child; Child, Preschool; Flavivirus/*immunology; Flavivirus Infections/epidemiology; Hemagglutination Inhibition Tests; Humans; Nigeria; Togaviridae/*immunology; Togaviridae Infections/epidemiology","A survey for haemagglutination-inhibiting arthropod-borne virus antibody was carried out in the Kainji Lake area of Nigeria. Of 267 persons tested, 139 (52%) and 158 (59%) had alphavirus and flavivirus group HI antibody, respectively. The prevalence of antibody to individual virus antigen is as follows: Chikungunya, 45%; Semliki Forest, 25%; Sindbis, 33%, Yellow fever, 31%, Dengue type 2, 46%; and Zika 56%. The presence of high antibody rates to Chikungunya, Dengue type 2 and Yellow fever viruses is of public health significance. These viruses have been identified as the most important arthropod-borne viruses causing human infections in Nigeria.",Pubmed,March 31, 2016,Yes,,No,"Zika, indirect evidence or other topic",Scientific (journal) article,Yes,Original research,No,Yes,86,Clinical/epidemiological research,Cross-sectional study
87,"Olson, Ann Trop Med Parasitol, 1983",Olson,"Olson, J. G., Ksiazek, T. G., Gubler, D. J., Lubis, S. I., Simanjuntak, G., Lee, V. H., Nalim, S., Juslis, K., See, R.","A survey for arboviral antibodies in sera of humans and animals in Lombok, Republic of Indonesia",Ann Trop Med Parasitol,77,2,131-7,1983,1980-1989,April 1, 1983,6309104,,1459,English,,,,,,,"Alphavirus/*immunology, Animals, Antibodies, Viral/*analysis, Birds/immunology, Cattle, Chickens/immunology, Chiroptera/immunology, Ducks/immunology, Female, Flavivirus/*immunology, Goats/immunology, Hemagglutination Inhibition Tests, Horses/immunology, Humans, Indonesia, Male, Neutralization Tests, Rats","Sera were collected from humans, cattle, horses, goats, ducks, chickens, wild birds, bats and rats in Lombok, Indonesia, and were tested by haemagglutination inhibition (HI) for antibodies to JE, ZIKA, CHIK and RR. Selected sera were tested by microneutralization tests for antibodies to the following viruses: JE, ZIKA, MVE, TMU, LGT, KUN, SEP, DEN-2, CHIK, RR, GET, SIN, BUN, BAT and BAK. Human sera had JE HI antibody in 135 (30%) of 446 tested. Neutralization tests indicated that DEN-2, ZIKA, TMU, KUN and SEP may have caused flavivirus infections. Antibodies to other arboviruses tested for were not found. HI and neutralization tests on animal sera indicated possible flavivirus infections with JE, MVE, KUN and SEP, and also that infections with BAT and BUN had occurred among domestic animals. No neutralizing antibodies were found for alphaviruses or other viruses used in the tests.",Pubmed,March 31, 2016,No,No full-text obtained yet,,,Scientific (journal) article,Yes,Original research,No,Yes,87,Clinical/epidemiological research,Cross-sectional study
88,"Monath, Am J Trop Med Hyg, 1984",Monath,"Monath, T. P., Schlesinger, J. J., Brandriss, M. W., Cropp, C. B., Prange, W. C.",Yellow fever monoclonal antibodies: type-specific and cross-reactive determinants identified by immunofluorescence,Am J Trop Med Hyg,33,4,695-8,1984,1980-1989,July 1, 1984,6206738,,1458,English,,,,,,,"Animals, Antibodies, Monoclonal/*immunology, Antibodies, Viral/*immunology, Antigens, Viral/*immunology, Cross Reactions, Epitopes/immunology, Fluorescent Antibody Technique, Mice, Viral Envelope Proteins/immunology, Viral Proteins/immunology, Yellow fever virus/classification/*immunology","Monoclonal antibodies directed against the envelope glycoprotein and the NV3 non-structural viral protein of yellow fever (YF) were tested by the indirect fluorescent antibody technique against a variety of YF virus strains and heterologous flaviviruses. Monoclonal antibodies directed against the envelope glycoprotein exhibited YF strain-specificity, YF type-specificity, broad group cross-reactivity, or limited subgroup reactivity (YF + Banzi or YF + Koutango + Zika + Usutu + Uganda S). Monoclonal antibodies directed against NV3 reacted either with YF + Koutango or with YF + Banzi. These findings generally correlated with the results of biological tests reported previously. Monoclonal antibodies that were type-specific to YF will be useful for the rapid specific identification of YF virus isolates and are available from the Centers for Disease Control on request.",Pubmed,March 31, 2016,Yes,,No,"Zika, indirect evidence or other topic",Scientific (journal) article,Yes,Original research,No,Yes,88,Basic and applied biomedical research,In vitro experiment
89,"Fagbami, Afr J Med Med Sci, 1986",Fagbami,"Fagbami, A. H.; Halstead, S. B.",Antibody-mediated enhancement of Wesselsbron virus in P388D1 cells,Afr J Med Med Sci,15,03. Apr,103-7,1986,1980-1989,September 1, 1986,3031959,,1457,English,http://www.ncbi.nlm.nih.gov/pubmed/3031959,,Nigeria,Africa,United States,Public/Government,"Animals; Antibodies, Viral/*immunology; Cell Line; Flavivirus/immunology/*physiology; Neutralization Tests; Virus Replication","Antibody-mediated enhancement of Wesselsbron virus was investigated in P388D1 cell cultures. Virus infection was enhanced in culture by various dilutions of homologous and heterologous flavivirus antibody. Highest enhancement ratios and enhancing antibody titres were obtained with the homologous antibody. Enhancement of Wesselsbron virus infection in P388D1 cultures was also dependent on the multiplicity of infection (MOI) used; cultures infected at the lowest MOI produced the highest enhancement ratios. Of the four heterologous flavivirus IMAF tested for ability to enhance Wesselsbron virus infection, Potiskum virus antibody produced highest fold enhancement and possessed the highest enhancing antibody titre. Zika, Uganda S and Dakar bat IMAF produced lower fold enhancement and had lower enhancing antibody titres.",Pubmed,March 31, 2016,Yes,,No,"Zika, indirect evidence or other topic",Scientific (journal) article,Yes,Original research,No,Yes,89,Basic and applied biomedical research,In vitro experiment
90,"Saluzzo, Annales de l'Institut Pasteur Virology, 1986",Saluzzo,"Saluzzo, J. F., Sarthou, J. L., Cornet, M.",Specific ELISA-IgM antibodies for diagnosis and epidemiological surveillance of flaviviruses in Africa. [French],Annales de l'Institut Pasteur Virology,137,2,155-170,1986,1980-1989,,1986167081,,1735,French,http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emed1b&AN=1986167081,"(Saluzzo, Sarthou, Cornet) Institut Pasteur de Dakar, Dakar Senegal, Institut Pasteur de Dakar, Dakar Senegal",,,,,"diagnosis, enzyme linked immunosorbent assay, Flavivirus, human, liver, methodology, monkey, priority journal, serodiagnosis, seroepidemiology, yellow fever, complement fixing antibody, immunoglobulin M","The complement-fixation (CF) test and IgM antibody-capture enzyme-linked immunosorbent assay (ELISA) were compared for the serological diagnosis of medically important flavivirus infections in Africa. The specificity and kinetics of antibody development were studied using serum specimens from humans during investigation of the 1983 yellow fever epidemic in Burkina Faso, from monkeys and young children in eastern Senegal, and from persons with clinical flavivirus infections. IgM antibodies detected by ELISA showed complete specificity in cases of yellow fever, Zika and Wesselsbron infection, whereas extensive cross-reactions were noted by ELISA in dengue infections and by the CF test in the case of all flaviviruses. The combined use of end-point IgM ELISA and virus isolation permitted a specific diagnosis in all cases of yellow fever studied during the epidemic in Burkina Faso. These techniques thus provided a means of rapid diagnosis using a single serum sample, and should be applied in programs of surveillance and epidemic investigation. The persistence of IgM antibodies to yellow fever and Zika is relatively brief (1-3 months). Tests on a small number of cases of dengue 2 and 4 also indicated the brief duration of specific IgM compared to CF antibodies. The IgM ELISA has also been applied to the surveillance of sylvatic flavivirus transmission in eastern Senegal. With the successive isolation of yellow fever and Zika viruses in two years, the sensitivity and limits of the serological technique have been elucidated. The best approach for detection of flavivirus transmission is timely serological surveillance of young children; a minimum of one survey should be conducted at the end of the rainy season. Moreover, routine surveillance of wild monkeys for specific IgM antibodies allow early detection of flavivirus activity. This approach is especially useful for the planning and initiation of field studies to assess the occurrence of clinical infections, particularly those due to dengue virus. Two techniques for measurement of IgM antibodies by ELISA were compared. The indirect assay using peroxidase appears to be the most sensitive.",Embase,March 31, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Original research,No,Yes,90,Basic and applied biomedical research,Other basic research
91,"Fagbami, Cytobios, 1987",Fagbami,"Fagbami, A. H.; Halstead, S. B.; Marchette, N. J.; Larsen, K.",Cross-infection enhancement among African flaviviruses by immune mouse ascitic fluids,Cytobios,49,196,49-55,1987,1980-1989,January 1, 1987,3028713,,1456,English,http://www.ncbi.nlm.nih.gov/pubmed/3028713,,Nigeria,Africa,United States,Not reported/unknown,"Animals; Antibodies, Viral/immunology; Cell Line; Flavivirus/growth & development/immunology; Mice; Neutralization Tests; Togaviridae Infections/*immunology; Viral Plaque Assay","Cross-infection enhancement of seven African flaviviruses by subneutralising concentrations of antibody in immune ascitic fluids was investigated in P388D1 cell culture. Infection by all the seven flaviviruses tested was enhanced by homologous and at least one of six heterologous immune mouse ascitic fluids (IMAF) tested. Enhancement ratios and enhancing antibody titres were higher in homologous than in heterologous enhancement. Zika, Wesselsbron, Uganda S and West Nile viruses were enhanced in culture by all the IMAF tested. Enhancement of Dakar bat and Yellow fever viruses was produced by five heterologous IMAF, but Potiskum virus was enhanced by one heterologous flavivirus antibody. The antibody to Potiskum virus was the most potent mediator of heterologous infection enhancement; all six heterologous flaviviruses were markedly enhanced by this antibody.",Pubmed,March 31, 2016,Yes,,No,"Zika, indirect evidence or other topic",Scientific (journal) article,Yes,Original research,No,Yes,91,Basic and applied biomedical research,In vitro experiment
92,"Buckley, J Gen Virol, 1988",Buckley,"Buckley, A.; Gould, E. A.",Detection of virus-specific antigen in the nuclei or nucleoli of cells infected with Zika or Langat virus,J Gen Virol,69 ( Pt 8),,1913-20,1988,1980-1989,August 1, 1988,2841406,10.1099/0022-1317-69-8-1913,1455,English,http://www.ncbi.nlm.nih.gov/pubmed/2841406,"Arbovirus Research Unit, London School of Hygiene and Tropical Medicine, Winches Farm Field Station, St Albans, Hertfordshire, U.K.",,,,,"Animals; Antibodies, Monoclonal/immunology; Antibody Specificity; Antigens, Viral/*analysis; Autoradiography; Cell Nucleolus/*immunology; Cell Nucleus/*immunology; Encephalitis Viruses, Tick-Borne/*immunology; Encephalitis, Tick-Borne/diagnosis/immunology/virology; Fluorescent Antibody Technique; Hybridomas; Immunoassay; Vero Cells; Zika Virus/*immunology; Zika Virus Infection/diagnosis/immunology/virology","Two monoclonal antibodies (MAbs) with molecular specificities for either the viral envelope glycoprotein (MAb 541) or the non-structural NS1 glycoprotein (MAb 109) were derived using West Nile and yellow fever (YF) viruses respectively. Their antigenic reactivity with a large number of flaviviruses was tested by indirect immunofluorescence microscopy. Both produced cytoplasmic fluorescent staining patterns with the homologous virus against which they were raised. Additionally, MAb 541 reacted with two substrains of YF virus whereas MAb 109 reacted with Bussuquara, YF and Ntaya viruses. These reactions were exclusively cytoplasmic. Two unexpected patterns of fluorescent labelling were observed when the antibodies were tested with Zika and Langat viruses. MAb 541 produced fluorescent staining of the nuclei, but not the cytoplasm, of cells infected with Zika virus and MAb 109 labelled only the nucleoli of cells infected with Langat virus. Double-labelling experiments showed that the nuclear fluorescent label was confined to virus-infected cells, and antibody absorption experiments with virus-infected cell packs confirmed the virus specificity of the nuclear antigen. The unexpected presence of virus-specific antigen in the nuclei or nucleoli of Zika or Langat virus-infected cells brings into question the role of the nucleus in flavivirus replication.",Pubmed,March 31, 2016,Yes,,No,"Zika, indirect evidence or other topic",Scientific (journal) article,Yes,Original research,No,Yes,92,Basic and applied biomedical research,In vitro experiment
93,"Botros, J Med Virol, 1989",Botros,"Botros, B. A., Watts, D. M., Soliman, A. K., Salib, A. W., Moussa, M. I., Mursal, H., Douglas, C., Farah, M.","Serological evidence of dengue fever among refugees, Hargeysa, Somalia",J Med Virol,29,2,79-81,1989,1980-1989,October 1, 1989,2600591,,1454,English,,"Virology Division, U.S. Naval Medical Research Unit No. 3, Cairo, Egypt.",Egypt,Africa,Egypt,,"Antibodies, Viral/immunology, Dengue/*diagnosis, Disease Outbreaks, Humans, Immunoglobulin M/immunology, *Refugees, Somalia","Epidemics of a malaria-like illness affected several thousand residents of the Dam Camp, a refugee camp near Hargeysa in Somalia, during 1985, 1986, and 1987. The disease was characterized by fever, chills, sweats, headache, back and joint pains for as long as 10 days in some patients. Blood smears from acutely ill patients were negative for malaria. Of 28 acute and 10 convalescent sera tested by the indirect fluorescent antibody (IFA) and by the hemagglutination inhibition (HI) tests, all were negative for antibody to Rift Valley fever, Crimean-Congo hemorrhagic fever, Sindbis, Chikungunya, yellow fever, and Zika viruses. However, antibody reactive to dengue 2 virus was detected by the IFA test in 39% (15/38), and 11 of 29 (38%) of the same sera were antibody positive by the HI test. Also, IgG antibody reactive to dengue 2 was demonstrated in 60% (17/28) of the same sera by the enzyme immunoassay (EIA), and 14% (4/28) were positive for IgM antibody. Of ten patients for which acute and convalescent sera were available, two developed four fold or greater rises in antibody titer evidencing infection. These data suggested that dengue virus may have been the cause of the epidemic among the Dam Camp refugees.",Pubmed,March 31, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Original research,No,Yes,93,Clinical/epidemiological research,Cross-sectional study
94,"Rodhain, Trans R Soc Trop Med Hyg, 1989",Rodhain,"Rodhain, F.; Gonzalez, J. P.; Mercier, E.; Helynck, B.; Larouze, B.; Hannoun, C.","Arbovirus infections and viral haemorrhagic fevers in Uganda: a serological survey in Karamoja district, 1984",Trans R Soc Trop Med Hyg,83,6,851-4,1989,1980-1989,November 1, 1989,2559514,,1453,English,http://www.ncbi.nlm.nih.gov/pubmed/2559514,"Unite d'Ecologie des Systemes Vectoriels, Institut Pasteur, Paris, France.",,,,,"Adult; Alphavirus/immunology; Antibodies, Viral/*analysis; Arbovirus Infections/*epidemiology/immunology; Bunyaviridae/immunology; Chikungunya virus/immunology; Female; Flavivirus/immunology; Fluorescent Antibody Technique; Hemagglutination Inhibition Tests; Hemorrhagic Fevers, Viral/epidemiology/immunology; Humans; Male; Togaviridae Infections/epidemiology; Uganda/epidemiology; Zika Virus/immunology","Sera collected in May 1984 from 132 adult residents of Karamoja district, Uganda, were examined by haemagglutination inhibition tests for antibodies against selected arboviruses, namely Chikungunya and Semliki Forest alphaviruses (Togaviridae); dengue type 2, Wesselsbron, West Nile, yellow fever and Zika flaviviruses (Flaviviridae); Bunyamwera, Ilesha and Tahyna bunyaviruses (Bunyaviridae); and Sicilian sandfly fever phlebovirus (Bunyaviridae); and by immunofluorescence tests against certain haemorrhagic fever viruses, Lassa fever arenavirus (Arenaviridae), Ebola-Sudan, Ebola-Zaire and Marburg filoviruses (Filoviridae), Crimean-Congo haemorrhagic fever nairovirus and Rift Valley fever phlebovirus (Bunyaviridae). Antibodies against Chikungunya virus were the most prevalent (47%), followed by flavivirus antibodies (16%), which were probably due mainly to West Nile virus. No evidence of yellow fever or dengue virus circulation was observed. A few individuals had antibodies against Crimean-Congo haemorrhagic fever, Lassa, Ebola and Marburg viruses, suggesting that these viruses all circulate in the area.",Pubmed,March 31, 2016,Yes,,No,"Zika, indirect evidence or other topic",Scientific (journal) article,Yes,Original research,No,Yes,94,Clinical/epidemiological research,Cross-sectional study
95,"Miller, Am J Trop Med Hyg, 1991",Miller,"Miller, B. R.; Mitchell, C. J.",Genetic selection of a flavivirus-refractory strain of the yellow fever mosquito Aedes aegypti,Am J Trop Med Hyg,45,4,399-407,1991,1990-1999,October 1, 1991,1659238,,1452,English,http://www.ncbi.nlm.nih.gov/pubmed/1659238,"Medical Entomology-Ecology Branch, Centers for Disease Control, Fort Collins, Colorado.",,,,,Aedes/genetics/*virology; Animals; Dengue Virus/genetics/isolation & purification; Female; Flavivirus/classification/*genetics; Humans; Inbreeding; Insect Vectors/genetics/*virology; Macaca mulatta; Nigeria; Phenotype; Yellow fever virus/genetics/isolation & purification; Zika Virus/genetics/isolation & purification,"Two inbred (isofemale) Aedes aegypti mosquito lines were derived that manifested a resistant or susceptible phenotype following ingestion of yellow fever virus; lack of virus movement from the midgut defined the resistant phenotype. Other flaviviruses, including dengue 1-4, Uganda S, and Zika, viruses behaved in a similar fashion in the two mosquito lines. Crosses between the two lines produced progeny that were of intermediate susceptibility, indicating codominance; F2 backcrosses to the parents yielded results consistent with a major controlling genetic locus and provide evidence of a second locus capable of modulating the phenotype of the major gene. The rapid selection necessary to fix the susceptible and refractory phenotypes support the hypothesis of a single major controlling locus. Viral movement across the midgut is likely to be governed by a single major gene and modifying minor genes or a group of closely linked genes. These inbred mosquito lines will be useful in discovering the molecular basis for flavivirus resistance in Ae. aegypti.",Pubmed,March 31, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Original research,No,Yes,95,Basic and applied biomedical research,Animal experiment
96,"Karpel Vel Leitner, Water Research, 1992",Karpel Vel Leitner,"Karpel Vel Leitner, N., De Laat, J., Dore, M.",Photodecomposition of chlorine dioxide and chlorite by U.V.-irradiation - Part II. Kinetic study. [French],Water Research,26,12,1665-1672,1992,1990-1999,,1992349208,http://dx.doi.org/10.1016/0043-1354%2892%2990166-2,1706,French,http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emed2&AN=1992349208,"(Karpel Vel Leitner, De Laat, Dore) Lab. Chimie l'Eau et des Nuisances, URA 1468, Ecole Sup. Ingen. Poitiers, Universite de Poitiers, 40 avenue du Recteur Pineau, 86022 Poitiers Cedex, France, N. Karpel Vel Leitner, Lab. Chimie l'Eau et des Nuisances, URA 1468, Ecole Sup. Ingen. Poitiers, Universite de Poitiers, 40 avenue du Recteur Pineau, 86022 Poitiers Cedex, France",,,,,"article, chemical reaction kinetics, decomposition, photodegradation, photolysis, ultraviolet radiation, chlorate, chloride, chlorine dioxide, hypochlorite, oxygen","The decomposition of ClO<inf>2</inf> and ClO<inf>2</inf><sup>-</sup> by u.v. radiation leads to the production of chlorate chloride and oxygen as end-products via complex reactions which are initiated by the products generated by the primary reactions of photolysis (Buxton and Subhani, 1972a; Mialocq et al, 1973, Karpel Vel Leitner er al., 1992). As far as the rate of decomposition is concerned, Bowen and Cheung (1932) and Zika et al. (1985) have shown that the quantum yield of photodecomposition of chlorine dioxide (overall reaction) increases when the wavelength decreases [Zika er al. (1985): =0.46 at 366 nm and 1.4 at 296.7 nm]. However, the values of the quantum yield of photodecomposition of ClO<inf>2</inf> and ClO<inf>2</inf><sup>-</sup> at 253.7 nm as well as the quantum yields for the primary reactions of photolysis of ClO<inf>2</inf> and ClO<inf>2</inf><sup>-</sup> at different wavelengths are not given in the literature. The aim of this work was to study the kinetics of photodecomposition of chlorine dioxide and of chlorite by u.v. irradiation.",Embase,March 31, 2016,No,Unrelated to Zika virus,,,Scientific (journal) article,Yes,Original research,No,Yes,96,Basic and applied biomedical research,Other basic research
97,"Monlun, Bull Soc Pathol Exot, 1993",Monlun,"Monlun, E., Zeller, H., Le Guenno, B., Traore-Lamizana, M., Hervy, J. P., Adam, F., Ferrara, L., Fontenille, D., Sylla, R., Mondo, M., et al.,",[Surveillance of the circulation of arbovirus of medical interest in the region of eastern Senegal],Bull Soc Pathol Exot,86,1,21. Aug,1993,1990-1999,January 1, 1993,8099299,,1451,French,,"Institut Pasteur Dakar, Senegal.",,,,,"Animals, Antibodies, Viral/blood, Arbovirus Infections/*epidemiology/virology, Arboviruses/immunology/isolation & purification, Culicidae/virology, Dengue/epidemiology/virology, Dengue Virus/isolation & purification, Enzyme-Linked Immunosorbent Assay, Immunoglobulin M/blood, Senegal/epidemiology, Zika Virus/isolation & purification, Zika Virus Infection/epidemiology/virology","A study about the circulation of arboviruses of medical interest in southeastern Senegal was conducted from 1988 to 1991, during and around the periods of transmission. Specific IgM antibodies were detected by ELISA test in human sera, as a sign of a recent infection within 2 to 5 months. The comparison of the serological IgM results from human surveys in different villages, and the isolations of arboviruses from mosquitoes during the same period of time permitted a rapid and global evaluation of the circulation of these viruses. A low level of yellow fever virus activity was detected both in humans and mosquitoes in 1988 to 1990. A dengue 2 epizootic occurred in 1989-1990. Dengue 2 virus was isolated from humans and mosquitoes in 1990. Some dengue 2 outbreak may occur in the upcoming years. A Zika virus epizootic outbreak was observed each year. A human strain was isolated in 1990. The other flaviviruses (West-Nile, Kedougou, Wesselsbron), Chikungunya virus, Rift Valley Fever virus and Crimean-Congo Hemorrhagic Fever virus did not seem to present a major public health concern in southeastern Senegal.",Pubmed,March 31, 2016,No,No full-text obtained yet,,,Scientific (journal) article,Yes,Original research,No,Yes,97,Clinical/epidemiological research,Cross-sectional study
98,"Monlun, Bull Soc Pathol Exot, 1993",Monlun,"Monlun, E., Zeller, H., Le Guenno, B., Traore-Lamizana, M., Hervy, J. P., Adam, F., Ferrara, L., Fontenille, D., Sylla, R., Mondo, M.",Surveillance of the circulation of arbovirus of medical interest in the region of eastern Senegal. [French],Bull Soc Pathol Exot,86,1,21-28,1993,1990-1999,,8099299,,1705,French,http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emed3&AN=8099299,"(Monlun, Zeller, Le Guenno, Traore-Lamizana, Hervy, Adam, Ferrara, Fontenille, Sylla, Mondo) Institut Pasteur Dakar, Senegal., E. Monlun, Institut Pasteur Dakar, Senegal.",,,,,"animal, Arbovirus, article, blood, dengue/ep [Epidemiology], Dengue virus, enzyme linked immunosorbent assay, immunology, isolation and purification, microbiology, mosquito, Senegal/ep [Epidemiology], virus infection/ep [Epidemiology], immunoglobulin M, virus antibody","A study about the circulation of arboviruses of medical interest in southeastern Senegal was conducted from 1988 to 1991, during and around the periods of transmission. Specific IgM antibodies were detected by ELISA test in human sera, as a sign of a recent infection within 2 to 5 months. The comparison of the serological IgM results from human surveys in different villages, and the isolations of arboviruses from mosquitoes during the same period of time permitted a rapid and global evaluation of the circulation of these viruses. A low level of yellow fever virus activity was detected both in humans and mosquitoes in 1988 to 1990. A dengue 2 epizootic occurred in 1989-1990. Dengue 2 virus was isolated from humans and mosquitoes in 1990. Some dengue 2 outbreak may occur in the upcoming years. A Zika virus epizootic outbreak was observed each year. A human strain was isolated in 1990. The other flaviviruses (West-Nile, Kedougou, Wesselsbron), Chikungunya virus, Rift Valley Fever virus and Crimean-Congo Hemorrhagic Fever virus did not seem to present a major public health concern in southeastern Senegal.",Embase,March 31, 2016,No,Duplicate of existing record,,,,,,,,,,
99,"Pierre, Res Virol, 1994",Pierre,"Pierre, V.; Drouet, M. T.; Deubel, V.",Identification of mosquito-borne flavivirus sequences using universal primers and reverse transcription/polymerase chain reaction,Res Virol,145,2,93-104,1994,1990-1999,March 1, 1994,7520190,,1450,English,http://www.ncbi.nlm.nih.gov/pubmed/7520190,"Unite des Arbovirus et virus des fievres hemorragiques, Institut Pasteur, Paris.",,,,,"Animals; Base Sequence; Cloning, Molecular; Conserved Sequence; Culicidae/microbiology; *DNA Primers; DNA, Viral/analysis; Flavivirus/*classification/*genetics; Genes, Viral/genetics; Male; Molecular Sequence Data; Phylogeny; Polymerase Chain Reaction/*methods; RNA-Directed DNA Polymerase; Regulatory Sequences, Nucleic Acid/genetics; Sensitivity and Specificity; Sequence Alignment; Sequence Analysis, DNA; Sequence Homology, Nucleic Acid; Viral Nonstructural Proteins/*genetics","A reverse transcription/polymerase chain reaction (RT/PCR) protocol for the rapid detection and identification of flaviviruses was developed using a set of universal oligonucleotide primers. These primers correspond to sequences in the 3' non-coding region and in the NS5 gene which are highly conserved among the mosquito-borne flaviviruses. The sequences of the resulting amplified products were analysed for dengue 1, dengue 2, dengue 3, dengue 4, Japanese encephalitis, West Nile, yellow fever and Zika viruses, and compared with the published sequences of other flaviviruses. The 291-297 nucleotides corresponding to the C-terminus of NS5 gene showed 56 to 76% similarity, whereas the 3' non-coding region (190 to 421 nucleotides) showed only 20 to 36% similarity. Genetic classification of the Zika virus supported its traditional serological grouping. Recombinant plasmids containing the flavivirus sequences were used in a nucleic acid hybridization test to identify the RT/PCR products derived from viral RNA extracted from experimentally infected mosquitoes. The plasmids were dotted on a strip of nitrocellulose membrane and incubated with the RT/PCR product labelled with digoxigenin during the PCR step. This is a valuable method for the rapid and specific identification of mosquito-borne flaviviruses in biological specimens and for subsequent sequence analysis.",Pubmed,March 31, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Original research,No,Yes,99,Basic and applied biomedical research,Other basic research
100,"Bigler, Berl Munch Tierarztl Wochenschr, 1994",Bigler,"Bigler, L., Oester, H.",[Raising pairs of young non-reproducing female rabbits in cages],Berl Munch Tierarztl Wochenschr,107,6,202-5,1994,1990-1999,June 1, 1994,8067992,,1449,German,,,,,,,"*Animal Husbandry, Animals, *Behavior, Animal, Dominance-Subordination, Female, Grooming, *Housing, Animal, Rabbits/*psychology, Sexual Behavior, Animal","From the age of three months 16 young females of the Hybrid strain ZIKA were kept in pairs in a cage which measured 60 x 68 x 56 cm and which had an elevated tier (30 x 60 cm). Over a period of seven months these pairs were observed (2 h) and examined morphologically once a month. A video recording during 24 h was conducted. These observations showed that the frequency of aggressive and sexual behaviours was not very high and was not the same with all pairs. The frequency of aggressive, sexual and subdominant behaviour varied during the investigation, sometimes even within a month. There were a lot of amicable behaviour patterns (allogrooming, friendly nose-to-nose, nose-to-body contacts) and the females spent a lot of time in body-contact. Except with one pair there were hardly found any injuries despite the observed aggressive encounters. The dominance hierarchy in the different pairs was clear from the beginning and remained so during the experiment. The dominant females showed aggressive and sexual behaviour more frequently, all subdominant animals went away more frequently. The results suggest that keeping females in pairs before breeding starts or keeping them in pairs as laboratory rabbits is basically possible though the relation has to be checked all the time. Sufficient possibilities for occupation and a good structure of room are important. Because the degree of sexual influence of the females is not clear yet, further clarifications are needed.",Pubmed,March 31, 2016,No,Unrelated to Zika virus,,,Scientific (journal) article,Yes,Original research,No,Yes,100,Basic and applied biomedical research,Animal experiment
101,"Rodier, Trans R Soc Trop Med Hyg, 1996",Rodier,"Rodier, G. R.; Gubler, D. J.; Cope, S. E.; Cropp, C. B.; Soliman, A. K.; Polycarpe, D.; Abdourhaman, M. A.; Parra, J. P.; Maslin, J.; Arthur, R. R.",Epidemic dengue 2 in the city of Djibouti 1991-1992,Trans R Soc Trop Med Hyg,90,3,237-40,1996,1990-1999,May 1, 1996,8758061,,1448,English,http://www.ncbi.nlm.nih.gov/pubmed/8758061,"US Naval Medical Research Unit no. 3, Cairo, Egypt.",,,,,"Adolescent; Adult; Aedes; Animals; Antibodies, Viral/blood; Child; Child, Preschool; Dengue/*epidemiology/immunology/virology; *Disease Outbreaks; Djibouti/epidemiology; Female; Flavivirus/classification/immunology/isolation & purification; Humans; Infant; Male; Middle Aged; Prospective Studies; Retrospective Studies; Seroepidemiologic Studies","From October 1991 to February 1992, an outbreak of acute fever (in which thick blood films were negative for malaria) spread rapidly in the city of Djibouti, Djibouti Republic, affecting all age groups and both nationals and foreigners. The estimated number of cases was 12,000. The clinical features were consistent with a non-haemorrhagic dengue-like illness. Serum samples from 91 patients were analysed serologically for flavivirus infection (dengue 1-4, West Nile, yellow fever, Zika, Banzi, and Uganda-S), and virus isolation was attempted. Twelve strains of dengue 2 virus were isolated. Dengue infection was confirmed by a 4-fold or greater rise in immunoglobulin (Ig) G antibody in paired serum specimens, the presence of IgM antibody, or isolation of the virus. Overall, 46 of the suspected cases (51%) were confirmed virologically or had serological evidence of a recent flavivirus infection. Statistical analysis showed that the presence of a rash was the best predictor of flavivirus seropositivity. In November 1992, Aedes aegypti was widespread and abundant in several districts of Djibouti city. A serological study of serum samples collected from Djiboutian military personnel 5 months before the epidemic showed that only 15/177 (8.5%) had flavivirus antibodies. These findings, together with a negative serosurvey for dengue serotypes 1-4 and yellow fever virus performed in 1987, support the conclusion that dengue 2 virus has only recently been introduced to Djibouti.",Pubmed,March 31, 2016,Yes,,No,"Zika, not relevant to causality framework",Scientific (journal) article,Yes,Original research,No,Yes,101,Clinical/epidemiological research,Cross-sectional study
102,"Drescher, Berl Munch Tierarztl Wochenschr, 1996",Drescher,"Drescher, B., Reiter, J.",[The optimization of group size for fattening rabbits in group housing on grids made of artificial material],Berl Munch Tierarztl Wochenschr,109,8,304-8,1996,1990-1999,August 1, 1996,9005840,,1447,German,,"Institut fur Umwelt- und Tierhygiene sowie Tiermedizin mit Tierklinik, Universitat Hohenheim.",,,,,"*Animal Husbandry, *Animal Welfare, Animals, *Behavior, Animal, Female, Floors and Floorcoverings, Health Status, *Housing, Animal, Male, Population Density, Rabbits/*growth & development/psychology","ZIKA-fattening rabbits in groups of 4, 8, 16, 32 and 64 animals (5 rabbits/m2) have been proved in 6 repetitions with all together 144 animals during the fattening period of nine weeks in regard to their fattening performance, health and behaviour. The aim was to find an optimal group size for fattening rabbits with respect to animal welfare. The results show, that fattening performance and health of the rabbits have not been influenced remarkably by group size, whereas behaviour was different in so far, as the rabbits in groups of 16 showed a greater percentage of relaxed positions as well as a remarkable smaller percentage of aggressive behaviour. Therefore the group with 16 fattening rabbits is that, which can be advised for the fattening of rabbits in the Hohenheimer group housing.",Pubmed,March 31, 2016,No,Unrelated to Zika virus,,,Scientific (journal) article,Yes,Original research,No,Yes,102,Basic and applied biomedical research,Animal experiment
103,"Pavlasek, Vet Med (Praha), 1996",Pavlasek,"Pavlasek, I., Lavicka, M., Tumova, E., Skrivan, M.",[Spontaneous Cryptosporidium infection in weaned rabbits],Vet Med (Praha),41,12,361-6,1996,1990-1999,December 1, 1996,9045499,,1446,Other,,"National Veterinary Institute, Praha, Czech Republic.",,,,,"Animals, *Cryptosporidiosis/genetics, *Cryptosporidium parvum, *Parasitic Diseases, Animal, *Rabbits/genetics/parasitology","The first occurrence of Cryptosporidium parvum Tyzzer, 1912 in broiler rabbits in the Czech Republic is reported. The protozoon was determined on the basis of morphometrical parameters of oocysts and of localization of endogenous developmental stages. The dynamics of natural Cryptosporidium infection was studied in a group of 72 young rabbits after weaning (their age ranging from 23-33 to 82-92 days) obtained from six large flocks and used in a feeding experiment. C. parvum was found in rabbits from four farms (Tab. I). Animals under observation were divided into 9 subgroups according to the genotype (Hyla 2000, California White, crosses of New Zealand x California, New Zealand White, Cunistar and Zika) as well as according to the farm of origin. The animals were housed in 28 cages under the conditions of two-floor cage technology. The upper floor consisted of cages housing three head, the lower floor two head each. The animals were fed ad libitum with commercial feed mixture (till the average age of 64.days supplemented with Robenidin as coccidiostat). During the first 10 days of observation pooled samples of droppings from each cage were examinated by flotation-centrifugation method according to Breza (1957) and Pavlasek (1991) in the intervals of three to four days, later one-week intervals. Post mortem scrapings from mucous epithelium taken from young rabbits were examinated (to reveal endogenous developmental stages of C. parvum) together with digesta (to detect oocysts of the protozoon) taken from the full length of the small intestine using method of native preparations and Giemsa stain. In one 37-day dead animal the small and large intestines were examined histologically. The maximum number of young rabbits infected with C. parvum were 30-40 and 33-43 days old (Fig. 1). In animals of this age category the oocysts of the protozoon were found in pooled samples in 11 and 12 cages (39.3 and 42.9%) from totally 28 cages under study. In rabbits of more than 50 days of age the occurrence of infection was significantly decreased (3.7%). During the experiment seven rabbits (9.7%) died; six of them (8.3%) at the age of 30-40 days. All these naturally infected and dead animals represented cases of monoinfection with C. parvum. The major clinical signs were typical diarrhoea lasting 3-5 days, inappetency, apathia, lethargy, prominent signs of exhaustion followed by dehydration of the organism. Atrophy of villi of the ileum in one of young rabbits was found histologically. Table II presents concrete data on significantly lower body weights (the decrease being 7-61.5%) as compared with rabbits of the same age not infected with cryptosporidia. It was not possible to evaluate objectively the differences in susceptibility to C. parvum infection between the individual genotypes of rabbits. As was found in the course of our further studies (unpublished data) a possible source of infection of young rabbits can be represented by their mothers in which oocysts are excreted sporadically shortly before parturition and during several days after it. Cryptosporidium infection (cryptosporidiosis) in flocks of broiler rabbits is taken as a new protozoal disease in the Czech Republic and C. parvum as one of possible agents in cases of disorders of digestive tract, namely in rabbits after weaning.",Pubmed,March 31, 2016,No,Unrelated to Zika virus,,,Scientific (journal) article,Yes,Original research,No,Yes,103,Basic and applied biomedical research,Animal experiment
104,"Seitz, Berl Munch Tierarztl Wochenschr, 1998",Seitz,"Seitz, K.; Hoy, S.; Lange, K.",[Effect of various factors on the suckling behavior of domestic rabbits],Berl Munch Tierarztl Wochenschr,111,2,48-52,1998,1990-1999,March 26, 1998,9513297,,1445,German,http://www.ncbi.nlm.nih.gov/pubmed/9513297,"Institut fur Tierzucht und Haustiergenetik der Justus-Liebig-Universitat Giessen, Hessische Landesanstalt fur Tierzucht Neu-Ulrichstein.",,,,,"Animals; *Animals, Suckling; Female; Lactation; Rabbits; *Sucking Behavior; Time Factors; Video Recording","An average number of 1.47 suckling events per 24 hours with a mean duration of 203 seconds per suckling was shown in investigations with 156 does (253 litter, 1.907 alive born pups) by continuous video recordings (infrared technique) over 1.045 periods with 24 hours. Two or more suckling periods with maximum of six sucklings per 24 h were recorded in 40% of all days. Number and duration of suckling events and also percentage of days with > or = 2 sucklings/24 hours were significantly influenced by genotype of does, parity and keeping system (flatdeck, get-away-cage). ZIKA-hybrids had the highest percentage of days with several suckling periods (52.7). Suckling activity had shown a circadian rhythm and was significantly correlated with dawn (light-dark as an inducing factor for suckling). 25% of all suckling events took place in the hour after the lights were turned off.",Pubmed,March 31, 2016,No,Unrelated to Zika virus,,,Scientific (journal) article,Yes,Original research,No,Yes,104,Basic and applied biomedical research,Animal experiment
105,"Peskin, FEBS Lett, 1998",Peskin,"Peskin, A. V., Labas, Y. A., Tikhonov, A. N.",Superoxide radical production by sponges Sycon sp,FEBS Lett,434,01. Feb,201-4,1998,1990-1999,September 17, 1998,9738478,,1444,English,,"Institute of Developmental Biology, Russian Academy of Sciences, Moscow. peskin@ibrran.msk.su",,,,,"Animals, Porifera/*metabolism, Seawater, Superoxides/*metabolism","Using the catechol Tiron as an O2-. scavenger, we showed that sea sponges (Sycon sp.) produce superoxide radicals in sea water at a high rate without any stimuli added. The rate of O2-. outflow from sponges to their water surroundings reaches a value of 0.5 nmol/min per sponge at pH 6.5. The generation of O2-. was inhibited by Cu,Zn-superoxide dismutase, and restored by the addition of KCN. We also confirmed the abiotic production of O2-. in sea water, detected earlier with a different method by Petasne and Zika [Nature 325 (1987) 516-518].",Pubmed,March 31, 2016,No,Unrelated to Zika virus,,,Scientific (journal) article,Yes,Original research,No,Yes,105,Basic and applied biomedical research,Other basic research
106,"Baba, Rev Inst Med Trop Sao Paulo, 1998",Baba,"Baba, S. S.; Fagbami, A. H.; Olaleye, O. D.",Antigenic relatedness of selected flaviviruses: study with homologous and heterologous immune mouse ascitic fluids,Rev Inst Med Trop Sao Paulo,40,6,343-9,1998,1990-1999,August 7, 1999,10436653,,1442,English,http://www.ncbi.nlm.nih.gov/pubmed/10436653,"Department of Veterinary Microbiology & Parasitology, Faculty of Veterinary Medicine, University of Maiduguri, Nigeria.",,,,,"Animals; Antibodies, Viral/*analysis; Antigenic Variation/*immunology; Antigens, Viral/*analysis/*immunology; Ascitic Fluid/*virology; Complement Fixation Tests; Cross Reactions; Flavivirus/classification/*immunology; Hemagglutination Inhibition Tests; Mice","The antigenic relationship of 9 flaviviruses, Yellow fever (YF), Wesselsbron (WSL), Uganda S (UGS), Potiskum (POT), West Nile (WN), Banzi (BAN), Zika (ZK), Dengue type 1 (DEN-1) and Dengue type 2 (DEN-2), was assessed by cross-haemagglutination-inhibition (Cross-HI) and cross-complement fixation (Cross-CF) reactions between each of the viruses and their homologous immune mouse ascitic fluids. Titre ratios were calculated using the heterologous and homologous titres. Cross-CF reactions revealed wider antigenic variations among viruses than Cross-HI reactions. There was no significant antigenic variation between WSL, POT and YF viruses using either of those methods. However, definite differences in antigenicity were observed between them and UGS, BAN and ZK viruses. There were no significant differences between UGS, BAN and ZK or between DEN-1 and DEN-2. The serological relationship among flaviviruses is important in establishing diagnosis and epidemiology of these infections in Africa.",Pubmed,March 31, 2016,Yes,,No,"Zika, indirect evidence or other topic",Scientific (journal) article,Yes,Original research,No,Yes,106,Basic and applied biomedical research,Other basic research
107,"Baba, Comp Immunol Microbiol Infect Dis, 1999",Baba,"Baba, S. S., Fagbami, A. H., Ojeh, C. K.",Preliminary studies on the use of solid-phase immunosorbent techniques for the rapid detection of Wesselsbron virus (WSLV) IgM by haemagglutination-inhibition,Comp Immunol Microbiol Infect Dis,22,1,71-9,1999,1990-1999,March 31, 1999,10099030,,1443,English,,"Department of Veterinary Microbiology and Parasitology, Faculty of Veterinary Medicine, University of Maiduguri, Nigeria.",,,,,"Adolescent, Adult, Antibodies, Viral/*analysis, Arthropod Vectors, Child, Child, Preschool, Flavivirus/immunology/*isolation & purification, Flavivirus Infections/*diagnosis/epidemiology, Hemagglutination Inhibition Tests/*methods, Humans, Immunoglobulin M/*analysis, *Immunosorbent Techniques, Infant, Nigeria/epidemiology, Prevalence","Serum samples from 446 randomly selected persons belonging to different age groups and locations in Nigeria were tested for the presence of WSLV IgM using the flavivirus haemagglutination-inhibition (HI) test adopted to the solid-phase immunosorbent technique (SPIT). 61 (14%) persons had IgM to WSLV only, while 9 (2%) persons had heterologous IgM to WSLV and two other flaviviruses, namely yellow fever and Uganda S viruses. There was a high prevalence of IgM in people of younger age groups than those in older groups. The majority of the IgM positive sera (67 (96%) of the 70 positive sera reacted to high titres (>21:80). With the conventional HI tests, 314 (70%) of the total sera tested had HI antibodies to one or more flaviviruses (yellow fever, West Nile, Potiskum, Zika and Uganda S) out of which 305/314 (97%) had antibodies to 3 or more flaviviruses used in the tests. Although SPIT may not be as sensitive as the conventional HI test, it was found to be more specific and could be adopted for the detection of early WSLV infections in flavivirus hyperendemic environments.",Pubmed,March 31, 2016,No,No full-text obtained yet,,,Scientific (journal) article,Yes,Original research,No,Yes,107,Clinical/epidemiological research,Cross-sectional study
108,"Wolfe, Am J Trop Med Hyg, 2001",Wolfe,"Wolfe, N. D.; Kilbourn, A. M.; Karesh, W. B.; Rahman, H. A.; Bosi, E. J.; Cropp, B. C.; Andau, M.; Spielman, A.; Gubler, D. J.",Sylvatic transmission of arboviruses among Bornean orangutans,Am J Trop Med Hyg,64,05. Jun,310-6,2001,2000-2009,July 21, 2001,11463123,,1441,English,http://www.ncbi.nlm.nih.gov/pubmed/11463123,"Department of Immunology and Infectious Disease, Harvard School of Public Health, Boston, Massachusetts 02115, USA.",,,,Mixed,"Animals; Antibodies, Viral/blood; Arbovirus Infections/*transmission; Arboviruses/classification/immunology/*isolation & purification; Borneo; Humans; Pongo pygmaeus/*virology","Wild populations of nonhuman primates live in regions of sylvatic arbovirus transmission. To assess the status of arbovirus transmission in Bornean forests and the susceptibility of wild orangutans to arboviral infection, blood samples of wild orangutans, semi-captive orangutans, and humans were examined. Samples were tested by viruses representing three families (Flaviviridae, Alphaviridae, and Bunyaviridae), including plaque reduction neutralization test for antibodies to dengue-2, Japanese encephalitis, Zika, Langat, Tembusu, Sindbis, Chikungunya, and Batai viruses. Both wild and semi-captive orangutan groups as well as local human populations showed serologic evidence of arbovirus infection. The presence of neutralizing antibodies among wild orangutans strongly suggests the existence of sylvatic cycles for dengue, Japanese encephalitis, and sindbis viruses in North Borneo. The present study demonstrates that orangutans are susceptible to arboviral infections in the wild, although the impact of arboviral infections on this endangered ape remain unknown.",Pubmed,March 31, 2016,Yes,,No,"Zika, indirect evidence or other topic",Scientific (journal) article,Yes,Original research,No,Yes,108,Clinical/epidemiological research,Cross-sectional study
109,"Akoua-Koffi, Bull Soc Pathol Exot, 2001",Akoua-Koffi,"Akoua-Koffi, C.; Diarrassouba, S.; Benie, V. B.; Ngbichi, J. M.; Bozoua, T.; Bosson, A.; Akran, V.; Carnevale, P.; Ehouman, A.",[Investigation surrounding a fatal case of yellow fever in Cote d'Ivoire in 1999],Bull Soc Pathol Exot,94,3,227-30,2001,2000-2009,October 30, 2001,11681215,,1440,French,http://www.ncbi.nlm.nih.gov/pubmed/11681215,"Institut Pasteur de Cote d'Ivoire (IPCI), Abidjan, Cote d'Ivoire.",,,,,"Adolescent; Adult; Aedes/virology; Animals; Antibodies, Viral/blood; Child; Child, Preschool; Cote d'Ivoire; Female; Flavivirus/classification/isolation & purification; Germany/ethnology; Humans; Immunoglobulin G/blood; Immunoglobulin M/blood; Infant; Insect Vectors; Male; Middle Aged; Yellow Fever/*epidemiology/transmission; Yellow fever virus/immunology/isolation & purification","Cote d'Ivoire is an endemic country for yellow fever, but no case was officially notified in recent years. In July 1999, however, one fatal case was reported. A German citizen was infected in the national park of Comoe, in the north eastern area of the country. In order to evaluate the extent of amaril virus circulation and the risk for local people, a virological, entomological and epidemiological investigation was carried out by the ministry of health, the OCCGE, the Cote d'Ivoire Pasteur Institute (IPCI) and the World Health Organisation in the area where the fatal case had been staying. 18 suspected and 24 confirmed mosquito catchers were identified by interview and a blood specimen was collected from each of them. In addition, 159 batches of mosquitoes from which 94 batches of potential vectors were collected; among the suspected cases, 22% were immunised against yellow fever. Serological and virological analyses were made at IPCI and the Paris Pasteur Institute by ELISA technique and isolation on cells cultures and newborn mice. All the suspicious sera and 87.5% of the catchers were positive for IgG anti-amaril virus. One catcher's serum was positive for IgM anti-amaril virus. 11 suspected sera were positive for IgG anti-dengue virus with 1 positive for IgM. 1 strain of amaril virus and 3 strains of Zika virus were isolated from mosquitoes at IPCI and confirmed by CRORA in Dakar. These results indicated that there is a yellow fever and dengue virus are prevalent among the human and vector populations in the study area. Preventive measures must be adopted to protect human beings at risk for amaril infection.",Pubmed,March 31, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Original research,No,Yes,109,Environmental and vector research,Ecological/animal cross-sectional
110,"Kilbourn, J Wildl Dis, 2003",Kilbourn,"Kilbourn, A. M.; Karesh, W. B.; Wolfe, N. D.; Bosi, E. J.; Cook, R. A.; Andau, M.","Health evaluation of free-ranging and semi-captive orangutans (Pongo pygmaeus pygmaeus) in Sabah, Malaysia",J Wildl Dis,39,1,73-83,2003,2000-2009,April 11, 2003,12685070,10.7589/0090-3558-39.1.73,1439,English,http://www.ncbi.nlm.nih.gov/pubmed/12685070,"Wildlife Conservation Society, 2300 Southern Blvd., Bronx, New York 10460, USA.",,,,,"Animals; Animals, Wild; Antibodies, Viral/blood; Ape Diseases/*epidemiology/parasitology/virology; Conservation of Natural Resources; Feces/parasitology/virology; Female; *Health Status; Malaysia/epidemiology; Male; Physical Examination/veterinary; *Pongo pygmaeus/blood; Protozoan Infections, Animal/*epidemiology; Seroepidemiologic Studies; Virus Diseases/epidemiology/*veterinary; Zoonoses","Baseline data on health of free-ranging wildlife is essential to evaluate impacts of habitat transformation and wildlife translocation, rehabilitation, and reintroduction programs. Health information on many species, especially great apes, is extremely limited. Between 1996 and 1998, 84 free-ranging orangutans captured for translocation, underwent a complete health evaluation. Analogous data were gathered from 60 semi-captive orangutans in Malaysia. Baseline hematology and serology; vitamin, mineral and pesticide levels; and results of health evaluations, including physical examination, provide a baseline for future monitoring. Free-ranging and semi-captive orangutans shared exposure to 11 of 47 viruses. The semi-captive orangutans had significantly higher prevalence of antibodies to adenovirus (P < 0.0005) and rota (SA 11) virus (P < 0.008). More free-ranging than semi-captive animals had antibodies to Japanese encephalitis virus (P < 0.08) and foamy virus (P = 0.05). Exposure to parainfluenza and langat viruses was detected exclusively in semi-captive animals and exposure to sinbis virus was only found in free-ranging orangutans. There was evidence of exposure to respiratory syncytial virus, coxsackie virus, dengue virus, and zika virus in both groups. Ebstein-Barr virus was ubiquitous in both groups. Prevalence of antibodies against mumps virus changed from 0% in 1996 to 45% in 1998. No antibodies were detected to many important zoonotic viral pathogens, including herpesvirus and hepatitis virus. Prevalence of Balantidium coli and Plasmodium pitheci infections and exposure to mycobacterium was higher in the semi-captive animals. Differences in exposure to pathogens between the groups may be due to environmental factors including differences in exposures to other species, habitat quality, nutritional status, and other potential stressors. Differences in health parameters between captive and free-ranging orangutans need to be considered when planning conservation areas, translocation procedures, and rehabilitation protocols. Because survival of the orangutan is linked to animal and ecosystem health, results of this study will assist wildlife conservation programs by providing baseline health information.",Pubmed,March 31, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Original research,No,Yes,110,Environmental and vector research,Ecological/animal cross-sectional
111,"Zika, Ann Gen Hosp Psychiatry, 2004",Zika,"Zika, C. A.; Nicolaou, I.; Gavalas, A.; Rekatas, G. V.; Tani, E.; Demopoulos, V. J.",Behavioral and antioxidant activity of a tosylbenz[g]indolamine derivative. A proposed better profile for a potential antipsychotic agent,Ann Gen Hosp Psychiatry,3,1,1,2004,2000-2009,,14711381,10.1186/1475-2832-3-1,1692,English,http://www.ncbi.nlm.nih.gov/pubmed/14711381,"Department of Pharmaceutical Chemistry, School of Pharmacy, Aristotle University of Thessaloniki, Thessaloniki, 54124 Greece. chzika@pharm.auth.gr",,,,,"animal behavior, animal experiment, antioxidant activity, article, controlled study, dopamine receptor blocking, dopaminergic system, dose response, drug receptor binding, hyperactivity, lipid peroxidation, liver microsome, male, motor activity, nonhuman, oxidative stress, rat, stereotypy, 4 toluenesulfonyl 6,7,8,9 tetrahydro n,n di n propyl 1h benz[g]indole 7 amine/cm [Drug Comparison], 4 toluenesulfonyl 6,7,8,9 tetrahydro n,n di n propyl 1h benz[g]indole 7 amine/dv [Drug Development], 4 toluenesulfonyl 6,7,8,9 tetrahydro n,n di n propyl 1h benz[g]indole 7 amine/do [Drug Dose], 4 toluenesulfonyl 6,7,8,9 tetrahydro n,n di n propyl 1h benz[g]indole 7 amine/ip [Intraperitoneal Drug Administration], 4 toluenesulfonyl 6,7,8,9 tetrahydro n,n di n propyl 1h benz[g]indole 7 amine/pd [Pharmacology], apomorphine/cm [Drug Comparison], apomorphine/do [Drug Dose], apomorphine/ip [Intraperitoneal Drug Administration], apomorphine/pd [Pharmacology], dopamine receptor blocking agent/cm [Drug Comparison], dopamine receptor blocking agent/dv [Drug Development], dopamine receptor blocking agent/do [Drug Dose], dopamine receptor blocking agent/ip [Intraperitoneal Drug Administration], dopamine receptor blocking agent/pd [Pharmacology], neuroleptic agent/an [Drug Analysis], neuroleptic agent/cm [Drug Comparison], neuroleptic agent/do [Drug Dose], neuroleptic agent/ip [Intraperitoneal Drug Administration], neuroleptic agent/pd [Pharmacology], toluene derivative/cm [Drug Comparison], toluene derivative/dv [Drug Development], toluene derivative/do [Drug Dose], toluene derivative/ip [Intraperitoneal Drug Administration], toluene derivative/pd [Pharmacology], unclassified drug","BACKGROUND: Tardive dyskinesia (TD) is a major limitation of older antipsychotics. Newer antipsychotics have various other side effects such as weight gain, hyperglycemia, etc. In a previous study we have shown that an indolamine molecule expresses a moderate binding affinity at the dopamine D2 and serotonin 5-HT1A receptors in in vitro competition binding assays. In the present work, we tested its p-toluenesulfonyl derivative (TPBIA) for behavioral effects in rats, related to interactions with central dopamine receptors and its antioxidant activity. METHODS: Adult male Fischer-344 rats grouped as: i) Untreated rats: TPBIA was administered i.p. in various doses ii) Apomorphine-treated rats: were treated with apomorphine (1 mg kg-1, i.p.) 10 min after the administration of TPBIA. Afterwards the rats were placed individually in the activity cage and their motor behaviour was recorded for the next 30 min The antioxidant potential of TPBIA was investigated in the model of in vitro non enzymatic lipid peroxidation. RESULTS: i) In non-pretreated rats, TPBIA reduces the activity by 39 and 82% respectively, ii) In apomorphine pretreated rats, TPBIA reverses the hyperactivity and stereotype behaviour induced by apomorphine. Also TPBIA completely inhibits the peroxidation of rat liver microsome preparations at concentrations of 0.5, 0.25 and 0.1 mM. CONCLUSION: TPBIA exerts dopamine antagonistic activity in the central nervous system. In addition, its antioxidant effect is a desirable property, since TD has been partially attributed, to oxidative stress. Further research is needed to test whether TPBIA may be used as an antipsychotic agent.",Embase,March 31, 2016,No,Unrelated to Zika virus,,,Scientific (journal) article,Yes,Original research,No,Yes,111,Basic and applied biomedical research,Animal experiment
112,"Baumann, Animal Welfare, 2005",Baumann,"Baumann, P., Oester, H., Stauffacher, M.",The use of a cat-flap at the nest entrance to mimic natural conditions in the breeding of fattening rabbits (Oryctolagus cuniculus),Animal Welfare,14,2,135-142,2005,2000-2009,,2005212392,,1691,English,http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emed7&AN=2005212392,"(Baumann, Oester) Centre for Proper Housing, Swiss Federal Veterinary Office, Burgerweg 21, 3052 Zollikofen, Switzerland (Baumann, Stauffacher) Swiss Federal Institute of Technology ETH, Institute of Animal Sciences INW, Physiology and Animal Husbandry, ETH Zentrum, 8092 Zurich, Switzerland, H. Oester, Centre for Proper Housing, Swiss Federal Veterinary Office, Burgerweg 21, 3052 Zollikofen, Switzerland. E-mail: Hans.Oester@bvet.admin.ch",,,,,"Animal welfare, Cat-flap, Maternal Behaviour, Nest access, Pup mortality, Rabbit, animal behavior, animal experiment, animal housing, animal husbandry, article, body weight, breeding, cage, controlled study, corticosterone blood level, female, forehead, forelimb, head, male, mortality, nesting, nonhuman, nose, stress, weaning, corticosterone/ec [Endogenous Compound], corticotropin","Management systems allowing free nest access are widely used in commercial rabbit breeding, but these produce a potential conflict with the doe's behavioural goal of a closed nest entrance. Furthermore, the restricted space in commercial breeding units prevents the doe from achieving a sufficient distance between her and the nest another highly adaptive behavioural goal. This can lead to behavioural problems and pup mortality higher than 20%, attributable to hypothermia, injuries, weakness caused by the scattering and crushing of pups, or even cannibalism. In this study we tested a type of nest entrance (a metal cat-flap) that visually closed the nest box while still allowing the doe free access during the first 15 days after parturition. The effects of a cat-flap access (group CF) and of a permanently open nest box (group O) on nest-related behaviour, general activity, and plasma corticosterone concentration of the does, and on the mortality and weight of the pups, were compared using 15 ZIKA does in each group. Over 24 h, there was no difference between the groups in the frequency of 'nest controls' (approaches or entries to the nest without nursing of pups). However, outside nursing hours, does in group O showed more 'head contacts' with the nest, whereas does in group CF performed more nose contacts and nesting activities outside the nest. Does in group O performed twice as many potentially disturbing nest contacts in this time than does in group CF and had a higher increase of corticosterone after the administration of exogenous adrenocorticotrophic hormone. Pup mortality from days 16 to 35 was significantly higher in group O, and pups born to does in group O left the nest earlier. There was no significant difference in the weaning weights of pups between the two groups. As does with a cat-flap at the nest entrance still showed repeated nest approaches, the cat-flap possibly did not block all nest stimuli from the does. Alternatively, it is possible that the repeated approaches to the next box result from its being one of very few attractive or interesting features in an otherwise barren environment. Removal of the nest box from the cage is an effective method to eliminate nest stimuli, but this increases work for the staff without improving the barren environment for the rabbits. A better way of increasing the distance between the doe and the nest as well as presenting a number of other attractive features, is group-housing of does. © 2005 Universities Federation for Animal Welfare.",Embase,March 31, 2016,No,Unrelated to Zika virus,,,Scientific (journal) article,Yes,Original research,No,Yes,112,Basic and applied biomedical research,Animal experiment
113,"Kuno, Arch Virol, 2007",Kuno,"Kuno, G.; Chang, G. J.","Full-length sequencing and genomic characterization of Bagaza, Kedougou, and Zika viruses",Arch Virol,152,4,687-96,2007,2000-2009,January 2, 2007,17195954,10.1007/s00705-006-0903-z,1438,English,http://www.ncbi.nlm.nih.gov/pubmed/17195954,"Arbovirus Diseases Branch, Division of Vector-Borne Infectious Diseases, National Center for Zoonotic, Vector-Borne, and Enteric Diseases, Centers for Disease Control and Prevention, Fort Collins, CO 80522-2087, USA. gok1@cdc.gov",,,,,"3' Untranslated Regions/genetics; Base Sequence; Conserved Sequence; DNA, Complementary; Dengue Virus/genetics; Flaviviridae/classification/*genetics; *Genome, Viral; Humans; Models, Molecular; Molecular Sequence Data; Nucleic Acid Conformation; Open Reading Frames; RNA, Viral/genetics; Sequence Analysis, DNA; Sequence Homology; Viral Proteins/*genetics; West Nile virus/genetics; Zika Virus/classification/*genetics","Many members of the genus Flavivirus are the agents of important diseases of humans, livestock, and wildlife. Currently, no complete genome sequence is available for the three African viruses, Bagaza, Zika, and Kedougou viruses, each representing a distinct virus subgroup according to the latest virus classification. In this study, we obtained a complete genome sequence of each of those three viruses and characterized the open reading frames (ORFs) with respect to gene sizes, cleavage sites, potential glycosylation sites, distribution of cysteine residues, and unique motifs. The sequences of the three viruses were then scanned across the entire length of the ORF against available sequences of other African flaviviruses and selected reference viruses for genetic relatedness. The data collectively indicated that Kedougou virus was close to dengue viruses but nonetheless distinct, while Bagaza virus shared genetic relatedness with West Nile virus in several genomic regions. In the non-coding regions, it was found that a particular organizational pattern of conserved sequences in the 3' terminal region generally correlated with the current virus grouping.",Pubmed,March 31, 2016,Yes,,No,"Zika, not relevant to causality framework",Scientific (journal) article,Yes,Original research,No,Yes,113,Basic and applied biomedical research,Sequence analysis and phylogenetics
114,"Faye, J Clin Virol, 2008",Faye,"Faye, O.; Faye, O.; Dupressoir, A.; Weidmann, M.; Ndiaye, M.; Alpha Sall, A.",One-step RT-PCR for detection of Zika virus,J Clin Virol,43,1,96-101,2008,2000-2009,August 5, 2008,18674965,10.1016/j.jcv.2008.05.005,1437,English,http://www.ncbi.nlm.nih.gov/pubmed/18674965,"Institut Pasteur de Dakar, 36 Avenue Pasteur, BP 220, Dakar, Senegal.",,,,,"Genetic Variation; RNA, Viral/isolation & purification; Reverse Transcriptase Polymerase Chain Reaction/*methods; Sensitivity and Specificity; Viral Envelope Proteins/*genetics; Zika Virus/genetics/*isolation & purification; Zika Virus Infection/*diagnosis","BACKGROUND: Zika virus (ZIKV) is an emerging mosquito-borne flavivirus circulating in Asia and Africa. Human infection induces an influenza-like syndrome that is associated with retro-orbital pain, oedema, lymphadenopathy, or diarrhea. Diagnosis of Zika fever requires virus isolation and serology, which are time consuming or cross-reactive. OBJECTIVE: To develop a one-step RT-PCR assay to detect ZIKV in human serum. STUDY DESIGN: An assay targeting the envelope protein coding region was designed and evaluated for its specificity, detection limit, repeatability, and capacity to detect ZIKV isolates collected over a 40-year period from various African countries and hosts. RESULTS: The assay's detection limit and repeatability were respectively 7.7pfu/reaction and 100% in serum and L-15 medium; none of 19 other flaviviruses tested were detected. CONCLUSIONS: The assay is rapid, sensitive, and specific to detect ZIKV in cell culture or serum, but needs to be validated for diagnosis using clinical samples.",Pubmed,March 31, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Original research,No,Yes,114,Basic and applied biomedical research,Other basic research
115,"Lanciotti, Emerg Infect Dis, 2008",Lanciotti,"Lanciotti, R. S.; Kosoy, O. L.; Laven, J. J.; Velez, J. O.; Lambert, A. J.; Johnson, A. J.; Stanfield, S. M.; Duffy, M. R.","Genetic and serologic properties of Zika virus associated with an epidemic, Yap State, Micronesia, 2007",Emerg Infect Dis,14,8,1232-9,2008,2000-2009,August 6, 2008,18680646,10.3201/eid1408.080287,1436,English,http://www.ncbi.nlm.nih.gov/pubmed/18680646,"Diagnostic and Reference Laboratory, Arbovirus Diseases Branch, Centers for Disease Control and Prevention, Fort Collins, Colorado 80521, USA. rsl2@cdc.gov",United States,Americas,United States,Public/Government,"Antibodies, Viral/blood; Base Sequence; *Disease Outbreaks; Humans; Immunoglobulin G/blood; Immunoglobulin M/blood; Micronesia/epidemiology; Phylogeny; RNA, Viral/genetics; Reverse Transcriptase Polymerase Chain Reaction; Serologic Tests; *Zika Virus/genetics/isolation & purification; *Zika Virus Infection/diagnosis/epidemiology/virology","Zika virus (ZIKV) is a mosquito-borne flavivirus first isolated in Uganda from a sentinel monkey in 1947. Mosquito and sentinel animal surveillance studies have demonstrated that ZIKV is endemic to Africa and Southeast Asia, yet reported human cases are rare, with <10 cases reported in the literature. In June 2007, an epidemic of fever and rash associated with ZIKV was detected in Yap State, Federated States of Micronesia. We report the genetic and serologic properties of the ZIKV associated with this epidemic.",Pubmed,March 31, 2016,Yes,,No,"Zika, indirect evidence or other topic",Scientific (journal) article,Yes,Original research,No,Yes,115,Basic and applied biomedical research,Sequence analysis and phylogenetics
116,"Barboza, Med Mal Infect, 2008",Barboza,"Barboza, P.; Tarantola, A.; Lassel, L.; Mollet, T.; Quatresous, I.; Paquet, C.",[Emerging viral infections in South East Asia and the Pacific region],Med Mal Infect,38,10,513-23,2008,2000-2009,September 6, 2008,18771865,10.1016/j.medmal.2008.06.011,1435,French,http://www.ncbi.nlm.nih.gov/pubmed/18771865,"Departement International et Tropical, Institut de Veille Sanitaire, Saint-Maurice Cedex, France. p.barboza@invs.sante.fr",,,,,"Alphavirus Infections/epidemiology; Asia, Southeastern/epidemiology; Communicable Diseases, Emerging/*epidemiology/virology; Flaviviridae Infections/epidemiology; Henipavirus Infections/epidemiology; Humans; Oceania; Reoviridae Infections/epidemiology; Rhabdoviridae Infections/epidemiology; Virus Diseases/*epidemiology","The epidemiology of several viral diseases underwent profound changes in South-East Asia and Oceania over the past decades. This was due to several factors, including the geographical distribution of vectors and the viruses they transmit; increasing traveling and trade; increasing ecological and demographic pressure. We reviewed the current state of knowledge based on published sources and available epidemiological data. The review was limited to potentially emerging viruses in Southeast Asia and the Pacific reported in human cases. Dengue, Chikungunya, and Japanese Encephalitis viruses have recurred on a yearly basis with a steady increase in these regions. Ross River and Barmah viruses now appear regularly in Australia, in an increasing number of cases. Nipah virus strikes regularly with limited but deadly epidemics in Southeast Asia. Finally, infections by lyssaviruses, Kunjin, Murray Valley, or Zika viruses were also reviewed.",Pubmed,March 31, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Review,No,Yes,116,Clinical/epidemiological research,Epidemiological/clinical review
117,"Jiang, Yi Chuan, 2008",Jiang,"Jiang, M. S.; Chen, S. Y.; Lai, S. J.; Deng, X. S.; Chen, Y.; Wan, J.",[Association between single nucleotide polymorphism of MC4R gene and carcass traits in rabbits],Yi Chuan,30,12,1574-8,2008,2000-2009,December 17, 2008,19073572,,1433,Other,http://www.ncbi.nlm.nih.gov/pubmed/19073572,"College of Animal Science and Technology, Sichuan Agricultural University, Ya'an 625014, China. jms.1699@163.com",,,,,"Animals; Body Weight/*genetics; Gene Frequency; Genotype; Polymerase Chain Reaction; Polymorphism, Single Nucleotide/*genetics; Polymorphism, Single-Stranded Conformational/genetics; Rabbits; Receptor, Melanocortin, Type 4/*genetics; Sequence Analysis, DNA","Single nucleotide polymorphisms in the coding sequence of melanoeortin-4 receptor (MC4R) gene were detected by PCR-SSCP and DNA sequencing method in Harbin white rabbit, Tianfu black rabbit, Belgian hare, ZIKA rabbit, and California rabbit breeds. A-->G conversion mutation at base position 237 was found with high frequency in Harbin white rabbit, Belgian hare, and Zika rabbit and low frequency in Tianfu black rabbit and California rabbit. The allele A was pre-dominant allele for each of meat rabbit breeds. AA genotype frequency was higher than AG genotype in the five studied rabbit breeds. GLM analysis for the effect of genotypes on performance traits demonstrated that AG genotype was significantly associated with body weight, eviscerated weight and feed conversion efficiency (P<0.05), but not significantly associated with cooking loss (P>0.05). It was concluded from the results that MC4R gene could be a candidate modifier gene that affects or controls body weight and carcass traits of rabbit.",Pubmed,March 31, 2016,No,Unrelated to Zika virus,,,Scientific (journal) article,Yes,Original research,No,Yes,117,Basic and applied biomedical research,Animal experiment
118,"Deng, Yi Chuan, 2008",Deng,"Deng, X. S.; Wan, J.; Chen, S. Y.; Wang, Y.; Lai, S. J.; Jiang, M. S.; Xu, M.",[The correlations between polymorphism of growth hormone receptor gene and butcher traits in rabbit],Yi Chuan,30,11,1427-32,2008,2000-2009,December 17, 2008,19073551,,1434,Other,http://www.ncbi.nlm.nih.gov/pubmed/19073551,"Animal Science and Technological College, Sichuan Agricultural University, Ya'an 625014, China. deng198110@yahoo.com.cn",,,,,"Animals; Base Sequence; Body Weight/*genetics; Exons/genetics; Female; Gene Frequency; Genotype; Least-Squares Analysis; Male; Meat; Polymerase Chain Reaction; *Polymorphism, Genetic; Polymorphism, Single Nucleotide; Polymorphism, Single-Stranded Conformational; Rabbits/*anatomy & histology/*genetics; Receptors, Somatotropin/*genetics; Sequence Analysis, DNA","Five rabbit populations (Belgian hare, Tianfu black rabbit, Great line of Zika rabbit, Harbin white rabbit, and California rabbit) were used to analyze the polymorphism of growth hormone receptor (GHR) gene by PCR-SSCP. Results indicated that there were two mutation sites (C705T and C810T) in the 5 populations. The least square analyses showed that the live weight, visceraste weight, and slaughter percentage of AA and MM genotypes were significantly lower than BB and NN genotypes (P<0.05). In contrast, the GHR polymorphism had no significant difference for least squares means of feed transformation efficiency (P>0.05). It suggested that GHR gene may be a candidate gene responsible for butcher trait in rabbit.",Pubmed,March 31, 2016,No,Unrelated to Zika virus,,,Scientific (journal) article,Yes,Original research,No,Yes,118,Basic and applied biomedical research,Sequence analysis and phylogenetics
119,"Gould, Lancet, 2008",Gould,"Gould, E. A., Solomon, T.",Pathogenic flaviviruses,Lancet,371,9611,500-9,2008,2000-2009,,18262042,10.1016/S0140-6736(08)60238-X,1898,,http://www.ncbi.nlm.nih.gov/pubmed/18262042,"CEH Oxford, Mansfield Road, Oxford, UK. eag@ceh.ac.uk",,,,,"Child, Dengue/diagnosis, Disease Outbreaks, Encephalitis, Japanese/diagnosis, Flavivirus/*pathogenicity, Flavivirus Infections/*epidemiology/prevention & control, Humans, Risk Factors, Tick-Borne Diseases/diagnosis/virology, Yellow Fever/diagnosis","Haemorrhagic disease, encephalitis, biphasic fever, flaccid paralysis, and jaundice are typical manifestations of diseases in human beings after infections by mosquito-borne or tick-borne flaviviruses such as yellow fever, dengue, West Nile, St Louis encephalitis, Japanese encephalitis, tick-borne encephalitis, Kyasanur Forest disease, and Omsk haemorrhagic fever. Although the characteristics of these viruses are well defined, they are still unpredictable with increases in disease severity, unusual clinical manifestations, unexpected methods of transmission, long-term persistence, and the discovery of new species. This Seminar will compare the epidemiological and clinical features of the medically important flaviviruses, consider the effect of human activity on their evolution and dispersal, and draw attention to new findings and some of the unanswered questions, unresolved issues, and controversies that remain.",Lancet,March 31, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Review,No,Yes,119,Clinical/epidemiological research,Epidemiological/clinical review
120,"Duffy, N Engl J Med, 2009",Duffy,"Duffy, M. R., Chen, T. H., Hancock, W. T., Powers, A. M., Kool, J. L., Lanciotti, R. S., Pretrick, M., Marfel, M., Holzbauer, S., Dubray, C., Guillaumot, L., Griggs, A., Bel, M., Lambert, A. J., Laven, J., Kosoy, O., Panella, A., Biggerstaff, B. J., Fischer, M., Hayes, E. B.","Zika virus outbreak on Yap Island, Federated States of Micronesia",N Engl J Med,360,24,2536-43,2009,2000-2009,June 12, 2009,19516034,10.1056/NEJMoa0805715,1432,English,,"Division of Vector-Borne Infectious Diseases, National Center for Zoonotic, Vector-Borne, and Enteric Diseases, Centers for Disease Control and Prevention, Fort Collins, CO 80521, USA.",United States,Americas,United States,Public/Government,"Adolescent, Adult, Aedes, Age Distribution, Animals, Antibodies, Viral/blood, Arthralgia/virology, Child, Child, Preschool, Conjunctivitis, Viral/virology, Dengue Virus/immunology, *Disease Outbreaks, Exanthema/virology, Fever/etiology, Humans, Immunoglobulin M/blood, Infant, Insect Vectors, Micronesia/epidemiology, Middle Aged, Population Surveillance, RNA, Viral/blood, Sex Distribution, Young Adult, *Zika Virus/genetics/immunology/isolation & purification, Zika Virus Infection/complications/*epidemiology/virology","BACKGROUND: In 2007, physicians on Yap Island reported an outbreak of illness characterized by rash, conjunctivitis, and arthralgia. Although serum from some patients had IgM antibody against dengue virus, the illness seemed clinically distinct from previously detected dengue. Subsequent testing with the use of consensus primers detected Zika virus RNA in the serum of the patients but no dengue virus or other arboviral RNA. No previous outbreaks and only 14 cases of Zika virus disease have been previously documented. METHODS: We obtained serum samples from patients and interviewed patients for information on clinical signs and symptoms. Zika virus disease was confirmed by a finding of Zika virus RNA or a specific neutralizing antibody response to Zika virus in the serum. Patients with IgM antibody against Zika virus who had a potentially cross-reactive neutralizing-antibody response were classified as having probable Zika virus disease. We conducted a household survey to estimate the proportion of Yap residents with IgM antibody against Zika virus and to identify possible mosquito vectors of Zika virus. RESULTS: We identified 49 confirmed and 59 probable cases of Zika virus disease. The patients resided in 9 of the 10 municipalities on Yap. Rash, fever, arthralgia, and conjunctivitis were common symptoms. No hospitalizations, hemorrhagic manifestations, or deaths due to Zika virus were reported. We estimated that 73% (95% confidence interval, 68 to 77) of Yap residents 3 years of age or older had been recently infected with Zika virus. Aedes hensilli was the predominant mosquito species identified. CONCLUSIONS: This outbreak of Zika virus illness in Micronesia represents transmission of Zika virus outside Africa and Asia. Although most patients had mild illness, clinicians and public health officials should be aware of the risk of further expansion of Zika virus transmission.",Pubmed,March 31, 2016,Yes,,Yes,,Scientific (journal) article,Yes,Original research,No,Yes,120,Clinical/epidemiological research,Ecological study/outbreak report
121,"Duong, Med Trop (Mars), 2009",Duong,"Duong, V.; Vong, S.; Buchy, P.",[Dengue and other arboviral diseases in South-East Asia],Med Trop (Mars),69,4,339-44,2009,2000-2009,September 4, 2009,19725383,,1431,French,http://www.ncbi.nlm.nih.gov/pubmed/19725383,"Unite de virologie, Institut Pasteur du Cambodge, Phnom Penh, Cambodge.",,,,,"Animals; Arbovirus Infections/*epidemiology/transmission; *Arboviruses; Asia, Southeastern/epidemiology; Culicidae; Dengue/*epidemiology/transmission; Humans; Insect Vectors","The most medically significant arboviruses causing human illness in south-east Asia belong to the genera Flavivirus (dengue, Japanese encephalitis, Kunjin, Zika, etc.) and Alphavirus (Chikungunya, Sindbis, Getah, etc.). All of these arboviral diseases are transmitted by mosquitoes. Dengue virus is the most prevalent arbovirus in south-east Asia and constitutes a major public health problem. Japanese encephalitis virus is also widespread in the region and symptomatic infection is associated with high mortality and severe neurological morbidity. Chikungunya virus causes mild but extremely painful illness. The number of Chikungunya cases has been increasing since early 2009. Epidemiological data show a steady, sometimes exponential, increase in the number of arbovirus infections in Asia. The spread of these viral infections can be linked to a number of complex factors.",Pubmed,March 31, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Review,No,Yes,121,Clinical/epidemiological research,Epidemiological/clinical review
122,"Hayes, Emerg Infect Dis, 2009",Hayes,"Hayes, E. B.",Zika virus outside Africa,Emerg Infect Dis,15,9,1347-50,2009,2000-2009,October 1, 2009,19788800,10.3201/eid1509.090442,1429,English,,"Barcelona Centre for International Health Research, Barcelona, Spain. ned.hayes@cresib.cat",,,,,"Aedes/virology, Animals, Antibodies, Viral/blood, Child, Child, Preschool, *Communicable Diseases,, Emerging/epidemiology/physiopathology/transmission/virology, Humans, Infant, Insect Vectors/virology, Male, Mice, Micronesia/epidemiology, Phylogeny, RNA, Viral/blood, *Zika Virus/classification/genetics/isolation & purification, Zika Virus Infection/*epidemiology/physiopathology/*transmission","Zika virus (ZIKV) is a flavivirus related to yellow fever, dengue, West Nile, and Japanese encephalitis viruses. In 2007 ZIKV caused an outbreak of relatively mild disease characterized by rash, arthralgia, and conjunctivitis on Yap Island in the southwestern Pacific Ocean. This was the first time that ZIKV was detected outside of Africa and Asia. The history, transmission dynamics, virology, and clinical manifestations of ZIKV disease are discussed, along with the possibility for diagnostic confusion between ZIKV illness and dengue.The emergence of ZIKV outside of its previously known geographic range should prompt awareness of the potential for ZIKV to spread to other Pacific islands and the Americas.",Pubmed,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,122,,
123,"Volper, Am J Trop Med Hyg, 2009",Volper,"Volper, E. M., Olekszak, H., Cropp, B., Meeks, J., Johnson, A. J., Imrie, A., Gubler, D. J., Nerurkar, V. R.",Validation of a multiplex microsphere-based immunoassay for measurement of anti-dengue virus immunoglobulin antibodies,Am J Trop Med Hyg,1,,26,2009,2000-2009,,70336570,,1684,English,http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emed9&AN=70336570,"(Volper, Olekszak, Cropp, Meeks, Johnson, Imrie, Gubler, Nerurkar) University of Hawaii, Honolulu, HI, United States, E.M. Volper, University of Hawaii, Honolulu, HI, United States",,,,,"Dengue virus, immunoassay, hygiene, society, tropical medicine, enzyme linked immunosorbent assay, serum, assay, cross reaction, diagnosis, laboratory, infection, patient, health care personnel, mosquito, Flavivirus, hospitalization, death, child, Asia, serodiagnosis, geographic distribution, Pacific islands, Pacific Islander, American Samoa, human, dilution, validation study, disease control, prevention, reproducibility, Palau, chikungunya, west nile flavivirus, virus, public health, St. Louis encephalitis, immunoglobulin antibody, microsphere, immunoglobulin G, immunoglobulin M antibody, neutralizing antibody, protein A","Dengue virus (DENV), a mosquito-borne flavivirus is a leading cause of hospitalization and death among children in south-east Asia. IgM antibody capture ELISA (MAC-ELISA) is primarily used as a test for DENV diagnosis, followed by a confirmatory plaque-reduction neutralization test (PRNT) to measure the level of DENV neutralizing antibodies. The objective of this study was to develop a rapid DENV IgG detection test using microspherebead based immunoassay (MBIA). 268 serum samples were obtained for diagnosis of DENV from patients with a wide range of age and geographic distribution within the Hawaiian Islands, and the Pacific Island Nations of Yap, Palau, French Polynesian and American Samoa. For determination of the negative cutoff value, serum specimens were obtained from 23 healthy individuals, and both suspected DENV- positive and -negative serum samples were confirmed using 90% PRNT on all 268 serum samples and DENV IgG indirect ELISA on 117 samples for the four DENV serotypes. A standard curve consisting of a known concentration of human IgG run with a serial dilution of Protein A bound to different bead sets was used to interpolate the concentration of IgG in serum samples. Of the 268 samples from patients and healthy controls, 168, were DENV MBIA and PRNT positive. Data obtained using MBIA, PRNT and IgG ELISA was 100% congruent. A validation study was coordinated between the Division of Vector-Borne infectious Diseases of the Centers for Disease Control and Prevention (DVBID) to determine (a) the reproducibility of the test between different laboratories, (b) the cross reactivity to St. Louis encephalitis (SLE), Chikungunya (CHIK), West Nile Virus (WNV), and Zika Virus (ZIKA), all of which share many clinical manifestations and are serologically similar when tested. The new MBIA assay was sent as a kit which contained everything necessary to complete the assay. Serum samples confirmed to be positive by PRNT and/or IgG ELISA for SLE, CHIK, WNV, ZIKA and DENV along with a negative panel were used by the CDC to run the MBIA assay. The kit was determined to be reproducible between two different laboratories. Some cross reaction was observed in SLE samples with minimum cross reactivity in CHIK, WNV and ZIKA samples. The newly developed DENV diagnostic assay will provide a rapid and sensitive alternative to ELISA for clinicians and public health workers, to prevent and control DENV infection and associated severe manifestations.",Embase,March 31, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Original research,No,Yes,123,Basic and applied biomedical research,Other basic research
124,"Derancourt, Nouvelles Dermatologiques, 2009",Derancourt,"Derancourt, C.",Zika virus epidemic on Yap Island. [French],Nouvelles Dermatologiques,28,8,423,2009,2000-2009,,2011348990,,1681,French,http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emed9&AN=2011348990,"(Derancourt) Service de Dermatologie, Hopital Pierre Zobda-Quitman, 97261 Fort-de-France Cedex, France, C. Derancourt, Service de Dermatologie, Hopital Pierre Zobda-Quitman, 97261 Fort-de-France Cedex, France",,,,,"nonhuman, note, virus, zika flavivirus",,Embase,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,124,,
125,"Weissenbock, Vet Microbiol, 2010",Weissenbock,"Weissenbock, H., Hubalek, Z., Bakonyi, T., Nowotny, N.",Zoonotic mosquito-borne flaviviruses: worldwide presence of agents with proven pathogenicity and potential candidates of future emerging diseases,Vet Microbiol,140,03. Apr,271-80,2010,2010-present,September 19, 2009,19762169,10.1016/j.vetmic.2009.08.025,1430,English,,"Institute of Pathology and Forensic Veterinary Medicine, Department of Pathobiology, University of Veterinary Medicine, Vienna, Austria. Herbert.Weissenboeck@vetmeduni.ac.at",,,,,"Animals, Communicable Diseases, Emerging/*epidemiology/*virology, Culicidae/*virology, Disease Vectors, Flavivirus/classification/isolation & purification, Flavivirus Infections/*epidemiology/*veterinary/virology, Humans, Zoonoses/*epidemiology/*virology","An update on the mosquito-borne flavivirus species including certain subtypes, as listed in the Eighth Report of the International Committee on Taxonomy of Viruses, is given. Special emphasis is placed on viruses which have been shown to cause diseases in animals, and viruses for which no pathogenicity has been proven yet. Several recent examples (Usutu virus and lineage-2 West Nile virus in central Europe, Zika virus in Micronesia) have shown that sources providing information on such scientifically largely neglected viruses are valuable tools for scientists and public health officials having to deal with such disease emergences. Furthermore the effects of global warming will lead to introduction of competent mosquito vectors into temperate climate zones and will increase efficiency of viral replication in less competent vector species. This, facilitated by rising global travel and trade activities, will facilitate introduction and permanent establishment of mosquito-borne viruses, some of which may become of public health or veterinary concern, into novel environments, e.g. industrialized countries worldwide.",Pubmed,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Yes,Review,No,Yes,125,Clinical/epidemiological research,Epidemiological/clinical review
126,"Fokam, East Afr Med J, 2010",Fokam,"Fokam, E. B., Levai, L. D., Guzman, H., Amelia, P. A., Titanji, V. P., Tesh, R. B., Weaver, S. C.",Silent circulation of arboviruses in Cameroon,East Afr Med J,87,6,262-8,2010,2010-present,June 1, 2010,23057269,,1428,English,,"Department of Plant and Animal Sciences, and Biotechnology Unit, University of Buea, Cameroon.",Cameroon,Africa,United States,Public/Government,"Arbovirus Infections/*epidemiology/*transmission/virology, Arboviruses/*isolation & purification, Cameroon/epidemiology, Humans","OBJECTIVES: To investigate the silent circulation and transmission of arthropod-borne viruses (arboviruses) in the Fako Division of Cameroon. DESIGN: This survey was conducted based on clinical observations and laboratory diagnosis; field collections of mosquitoes. SETTING: This study was conducted in the Fako Division of South West Cameroon. SUBJECTS: One hundred and two sera were obtained from febrile patients (with negative laboratory findings for malaria and typhoid fever) at clinics in the Fako Division, and diurnal anthropophilic mosquitoes (4,764) collected. INTERVENTIONS: Virus isolation was attempted from these, and sera were screened for antibodies against 18 African arboviruses by haemagglutination inhibition (HI) and complement fixation (CF) tests. RESULTS: No virus was isolated. Fifty three of 79 (67.1%) sera reacted with one or more viral antigens. Twenty nine sera (36.7%) reacted with members of the genus Alphavirus, with Chikungunya (CHIKV) and O'nyong-nyong (ONNV) viruses as the most frequent (34.2%). Forty six sera (58.2%) reacted with members of the genus Flavivirus: 24 (30.4%) were cross-reactive, but 11.4% reacted monotypically with Zika, 5.1% with yellow fever virus (YFV), 5.1% with dengue virus-2 (DENV-2), 2.5% with DENV-1 and 1.3% with Wesselsbron virus, respectively. The plaque reduction neutralisation test used to specify the agent that elicited the response could not resolve 33.3% of the cross reactions between CHIKV and ONNV. Neutralising antibody titres against ONNV and CHIKV were very high indicating probable re-infection. CONCLUSION: Our results indicate previously undetected circulation of arboviruses in Cameroon, and suggest that they are important, overlooked public health problems.",Pubmed,March 31, 2016,Yes,,No,"Zika, indirect evidence or other topic",Scientific (journal) article,Yes,Original research,No,Yes,126,Clinical/epidemiological research,Cross-sectional study
127,"Andonov, Vox Sanguinis, 2010",Andonov,"Andonov, A.",Current relevance of arbovirus infections in transfusion medicine,Vox Sanguinis,99,,31-32,2010,2010-present,,70236821,http://dx.doi.org/10.1111/j.1423-0410.2010.01343-1.x,1679,English,http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emed9&AN=70236821,"(Andonov) Public Health Agency of Canada, Winnipeg, Canada, A. Andonov, Public Health Agency of Canada, Winnipeg, Canada",,,,,"transfusion, blood transfusion, virus infection, society, Arbovirus, infection, virus, mosquito, Dengue virus, risk, donor, safety, vascularization, Colorado tick fever virus, genotype, west nile flavivirus, urbanization, poverty, climate change, travel, insecticide resistance, viremia, Japanese encephalitis virus, Federated States of Micronesia, public health, ecology, diagnosis, Southern Europe, malaria, advisory committee, Australia, Yellow fever flavivirus, pathogenesis, rift valley fever bunyavirus, Aedes albopictus, Europe, tick borne encephalitis flavivirus, screening, assay, RNA virus, plasticity, mutation, Chikungunya alphavirus, virus replication, adaptation, Asian, human, South America, blood, population, explosive, vaccine, rna, alanine, valine, glycoprotein","Arboviruses capable of causing large and often explosive outbreaks represent an important new challenge to the safety of the blood supply. The new era of globalization, massive urbanization, poverty, climate change, international travel, colonization by Aedes Albopictus mosquito of new territories both in tropical and temperate regions, insecticide resistance are among the main factors contributing to reemerging arborical diseases. Most if not all arboviruses have a relatively short viremic phase during the course of infection, but perhaps more importantly asymptomatic viremia may precede the onset of clinical disease by 1-2 days and therefore deferral of donors with potential unrecognized infection is undoable. Further to that arboviral infection is often asymptomatic and in the absence of suitable donor screening assays transfusion risk of infection may be considerable. Arboviruses like other RNA viruses have remarkable genomic plasticity and propensity to adapt when infecting different mosquito vectors; a single mutation alanine substituted by valine (A226V) in the E1 envelope glycoprotein of Chikungunya virus (CHIKV) significantly increased the viral replication and dissemination in Ae. Albopictus thus enhancing the transmission efficiency of infection with that vector. Similar process of adaptation, although not of the same importance has been observed once WNV became established in US; a new dominant genotype of the virus named WN02 became increasingly prevalent since 2002 displacing the original NY99 strain possibly due to increased transmission efficiency of the new genotype with domestic North American mosquitos. There are also observations that some current Asian strains of Dengue virus (DENV) may be more virulent for humans compared to strains circulating in South America. The above mentioned evidence of the adaptive capacity of different arboviruses obviously increases the risk of their global incursion. Arbovirus transmission through transfusion of blood products from asymptomatic donors has been documented for West Nile Virus (WNV), Dengue Virus, Tick-borne encephalitis (TBEV) virus, Colorado Tick Fever (CTFV) virus, and recently Yellow Fever virus (vaccine strain). Arbovirus transfusion transmitted infections pose a credible risk to the safety of the blood supply and although it is impossible to predict which pathogen may be on the top of the priority list currently of greatest concern are Dengue virus, CHIKV, O'nyong nyong virus, Rift Valley Virus and Japanese encephalitis virus which are considered exotic arboviruses for the temperate climatic zones. A worrisome trend is that arboviral infections are on the rise both in terms of magnitude of affected populations as well as in variety of incursions of individual viruses rarely heard before; a good example is Usutu virus emergence in Europe or Zika virus in Micronesia. Public health will play a major role in preventing and/or sustaining arboviral incursions when they occur. Key to development of real-time warning system for vector borne diseases is adequate surveillance. Examples of excellent networks specifically targeting arbovirus ecology are ArboNet in US, the European Mosquito Control Association (EMCA), the European Network for Diagnostics of Imported Viral Diseases (ENIVD), EpiSouth, a network for the Mediterranean region and the Balkans, the National Arbovirus and Malaria Advisory Committee (NAMAC) in Australia.",Embase,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,127,,
128,"Vrchotova, Journal of the Indian Chemical Society, 2010",Vrchotova,"Vrchotova, N.; Sera, B.; Dadakova, E.","HPLC and CE analysis of catechins, stilbens and quercetin in flowers and stems of Polygonum Cuspidatum, P. sachalinense and P. x bohemicum",Journal of the Indian Chemical Society,87,10,1267-1272,2010,2010-present,,209000000000,,1676,English,<Go to ISI>://:000209194200020,"Inst Syst Biol & Ecol AS CR, CZ-37005 Ceske Budejovice, Czech Republic; Univ South Bohemia, Fac Agr, CZ-37005 Ceske Budejovice, Czech Republic",,,,,biological activity; ce; hplc; knotweed; phenolic compounds; reynoutria,,Embase,March 31, 2016,No,Unrelated to Zika virus,,,Scientific (journal) article,Yes,Original research,No,Yes,128,Basic and applied biomedical research,Biochemical/protein structure studies
129,"Faye, BMC Proceedings. Conference: Institut Pasteur International Network Annual Scientific Meeting, 2010",Faye,"Faye, O., De Melo Freire, C. C., De Oliveira, J. V., Rubing, C., De Andrade Zanotto, P. M., Mawlouth, D., Sall, A. A.","Molecular evolution of Zika virus, an neglected emerging disease in Africa and Asia",BMC Proceedings. Conference: Institut Pasteur International Network Annual Scientific Meeting,5,no pagination,,2010,2010-present,,71500384,,1670,English,http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emed10&AN=71500384,"(Faye, Faye, Mawlouth, Sall) Institut Pasteur de Dakar, Dakar, Senegal (De Melo Freire, De Oliveira, De Andrade Zanotto) University of Sao Paulo, SP, Brazil (Rubing) University of Texas, Galveston, TX, United States, O. Faye, Institut Pasteur de Dakar, Dakar, Senegal",Senegal,Africa,Senegal,,"virus, Africa, Asia, molecular evolution, human, cote d'ivoire, Senegal, gene, genome, Malaysia, phylogeny, Federated States of Micronesia, Southeast Asia, Central Africa, molecular phylogeny, island (geological), population migration, Africa south of the Sahara, Arbovirus, Uganda, Central African Republic, Burkina Faso, forest, migration, mosquito, Asian, nucleotide","Zika virus (ZIKV) is an arbovirus transmitted by mosquitoes isolated for the first time in Zika forest, Uganda in 1947 and repeatedly isolated in sub-Saharan Africa and South East Asia. Until 2000, only few human cases were reported but in 2007, the first major human outbreak was notified in Yap Island, Micronesia leading to 99 cases. Despite the widespread distribution of Zika virus, very limited information is available on the genetic relationship between the circulating strains. Therefore, we undertook a study on phylogeny and phylodynamics ZIKV in Africa and Asia. Partial and full length genome sequences of 38 strains from Senegal, Ivory Coast, Burkina Faso, Central African Republic and Malaysia were analysed. Phylogenetic reconstructions and datation were performed while recombination and viral population migrations were investigated. Phylogenetic analysis of the E, NS5 and NS5/3'NC gene showed two distinct ZIKV lineages circulating in Africa and a third lineage formed by the Micronesia and Malaysia strains. Besides, analysis of full length genome sequence allows identification of 5 recombinants isolates in Senegal and Ivory Coast. The 3 gene regions sequences evolved at a average rate of 7.74 x 10-4 nucleotide substitutions per site per year. Using the same analysis, we inferred that the most recent common ancestor of all ZIKV samples could be trace 325 years ago. The virus may have arrived in West Africa around 300 years before the present. And the migration rates showed considerable movements of ZIKV between Senegal to Ivory Coast and also to the other countries of East and central Africa. In conclusion, our study confirms previous observations showing divergences between Africa ZIKV isolate from Asia and the evidence of recombinants strains. Asian strains may represent a divergent lineage related to a common ancestor with spread throughout Southeast Asia and the Pacific from Africa.",Embase,March 31, 2016,Yes,,No,"Zika, indirect evidence or other topic",Scientific (journal) article,Yes,Original research,No,Yes,129,Basic and applied biomedical research,Sequence analysis and phylogenetics
130,"De Araujo Lobo, Am J Trop Med Hyg, 2010",De Araujo Lobo,"De Araujo Lobo, J. M., Bausch, D. G., Mores, C. N.","Serological evidence of co-circulating dengue virus serotypes, an underreported arboviral disease in Guinea",Am J Trop Med Hyg,1,,314,2010,2010-present,,70443060,,1678,English,http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emed9&AN=70443060,"(De Araujo Lobo, Mores) Louisiana State University, Baton Rouge, LA, United States (Bausch) Tulane University, New Orleans, LA, United States, J.M. De Araujo Lobo, Louisiana State University, Baton Rouge, LA, United States",,,,,"hygiene, tropical medicine, Guinea, society, Dengue virus, dengue, infection, serotype, serum, human, Arbovirus, Dengue virus 1, virus, serodiagnosis, patient, general aspects of disease, city, malaria, cross reaction, immunity, cross protection, titrimetry, bird, nonhuman, arthropod, yellow fever, primate, hospital, neutralizing antibody, antibody","Arboviruses have been studied in arthropods, bats, birds, and nonhuman primates in Guinea, but only rarely in humans, with the exception of Yellow Fever (YF), which has caused outbreaks roughly bi-annually since 2000. In order to determine the frequency of human dengue disease in the Guinean towns of N'Zerekore and Faranah, we utilized a plaque reduction neutralization test (PRNT) for testing human serum samples. The serum samples were taken from patients that presented to hospital with acute febrile illness, who were ruled not to have malaria or lassa infections. The samples were tested for dengue serotype-specific neutralization antibodies in order to ascertain the occurrence of acute or recent infections. In the case of early infections, the dengue PRNT test presents significant serotype cross-reactivity and therefore it is not always possible to identify the primary virus serotype after a secondary dengue infection. Dengue specific antibodies are present early in the infection and can generate lifelong immunity to the infecting serotype, but only a few months of cross protection to the other serotypes. We found that among the 151 individuals tested, 19% serum samples had greater than 80% neutralization by one specific serotype, in which 33.3% sera samples reacted positively with dengue 1 virus, 33.3% samples reacted with dengue 2, 10% samples reacted positively with dengue 3, and 23.3% of samples with dengue 4. Furthermore, 21% samples had no detectable neutralization for any of the dengue serotypes, 3% bound with greater than 80% neutralization on all serotypes and the remaining 57% of samples cross reacted in diverse combinations of dengue virus 1, 2, 3, and 4. Endpoint titrations and cross neutralizations against YF, Zika, Usutu, and Koutango viruses are underway for these serum samples. These results strongly suggest that dengue, at least, and perhaps other various arboviruses, are circulating in and likely the cause of human disease in Guinea.",Embase,March 31, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Original research,No,Yes,130,Clinical/epidemiological research,Cross-sectional study
131,"Foy, Emerg Infect Dis, 2011",Foy,"Foy, B. D., Kobylinski, K. C., Chilson Foy, J. L., Blitvich, B. J., Travassos da Rosa, A., Haddow, A. D., Lanciotti, R. S., Tesh, R. B.","Probable non-vector-borne transmission of Zika virus, Colorado, USA",Emerg Infect Dis,17,5,880-2,2011,2010-present,May 3, 2011,21529401,10.3201/eid1705.101939,1427,English,,"Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado 80523-1692, USA. brian.foy@colostate.edu",,,,,"Adult, Animals, Cercopithecus aethiops, Colorado, Exanthema/etiology, Female, Humans, Male, Mice, RNA, Viral/genetics, Serologic Tests, Vero Cells, *Zika Virus/genetics/pathogenicity, Zika Virus Infection/complications/diagnosis/*transmission","Clinical and serologic evidence indicate that 2 American scientists contracted Zika virus infections while working in Senegal in 2008. One of the scientists transmitted this arbovirus to his wife after his return home. Direct contact is implicated as the transmission route, most likely as a sexually transmitted infection.",Pubmed,March 31, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Original research,No,Yes,131,Clinical/epidemiological research,Case report
132,"Crockett, Am J Trop Med Hyg, 2011",Crockett,"Crockett, R. J. K., Crabtree, M., Ledermann, J., Borland, E., Powers, A., Mutebi, J. P., Lutwama, J., Kityo, R., Towner, J., Amman, B., Nichol, S., Miller, B.",Investigations into mosquito blood feeding patterns on wildlife and a potential role for bats in arbovirus transmission cycles in Uganda,Am J Trop Med Hyg,1),,374-375,2011,2010-present,,71043413,,1671,English,"http://www.ajtmh.org/content/85/6_Suppl/351.full.pdf+html, http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emed10&AN=71043413","(Crockett, Crabtree, Ledermann, Borland, Powers, Mutebi, Miller) Centers for Disease Control and Prevention, Fort Collins, CO, United States (Lutwama) Uganda Virus Research Institute, Entebbe, Uganda (Kityo) Makerere University, Kampala, Uganda (Towner, Amman, Nichol) Centers for Disease Control and Prevention, Atlanta, GA, United States, R.J.K. Crockett, Centers for Disease Control and Prevention, Fort Collins, CO, United States",,,,,"mosquito, blood, feeding behavior, wildlife, Arbovirus, Uganda, society, tropical medicine, hygiene, species, human, fruit, exposure, forest, yellow fever, cave, virus, blood sampling, follow up, diseases, Culex, vertebrate, virus isolation, virus infection, tissues, serodiagnosis, chikungunya, dengue, Rift Valley fever, pathogenesis","Zoonotic and vector-borne pathogens have comprised a signifcant component of emerging human diseases in the last decade. Uganda has a history of enzootic and epizootic arbovirus activity and has been predicted as a hot spot for disease emergence. Serological evidence exists documenting exposure of various East African bat species to many arboviruses including Rift Valley fever, Yellow fever, West Nile, Usutu, Sindbis, Bunyamwera, and Zika viruses, however the role of bats in arbovirus transmission cycles is poorly understood. While collecting mosquitoes as part of an emerging arbovirus surveillance project in Uganda, we obtained blood-engorged Culex mosquitoes which had fed on fruit bats in both Semliki and Maramagambo Forests. To follow up on these observations and investigate the role of bats in arbovirus transmission cycles, blood samples from Rousettus aegypticus bats collected from the python cave in Maramagambo Forest were screened for West Nile, Yellow Fever, Dengue, Chikungunya, and O'nyong'nyong viruses by plaque reduction neutralization test (PRNT), and mosquitoes were trapped from around the vicinity of the cave. Blood and tissue samples were also collected from various fruit and insectivorous bat species in Kampala, Uganda and tested for evidence of arbovirus infection by PRNT and virus isolation. Serological and virological evidence will be presented on the arbovirus exposure history of several species of bats in Uganda. The blood feeding patterns of mosquitoes on a diversity of wildlife species in Uganda and potential enzootic arbovirus transmission cycles between mosquitoes and wild vertebrates including bats will be discussed.",Embase,March 31, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Original research,No,Yes,132,Environmental and vector research,Ecological/animal cross-sectional
133,"Heang, Am J Trop Med Hyg, 2011",Heang,"Heang, V., Yasuda, C. Y., Ngan, C., Kasper, M. R.",Zika virus from fever syndromic surveillance in Cambodia,Am J Trop Med Hyg,1),,183,2011,2010-present,,71042765,,1672,English,"http://www.ajtmh.org/content/85/6_Suppl/151.full.pdf+html, http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emed10&AN=71042765","(Heang, Yasuda) U.S. Naval Medical Research Unit No. 2, Phnom Penh, Cambodia (Ngan) National Dengue Control Program, Ministry of Health, Phnom Penh, Cambodia (Kasper) U.S. Naval Medical Research Unit No. 6, Lima, Peru, V. Heang, U.S. Naval Medical Research Unit No. 2, Phnom Penh, Cambodia",,,,,"fever, Cambodia, society, tropical medicine, hygiene, virus, dengue, serum, real time polymerase chain reaction, human, pathogenesis, serology, Japanese encephalitis, laboratory, coughing, sore throat, health, blood, headache, child, medical research, patient, convalescence, Cambodian, amplicon, identity, gene, nucleic acid, immunoglobulin M","In collaboration with the Cambodian Ministry of Health, US Naval Medical Research Unit 2, Cambodia has conducted fever syndromic surveillance study since 2006. Patients are currently being enrolled from 11 in 5 provinces in south central and northeastern Cambodia. Upon enrollment, respiratory specimens, whole blood and serum were collected. Testing was performed for viral, bacterial and parasitic pathogens at a centralized laboratory in Phnom Penh. Dengue fever is tested for by serological (IgM) and molecular methods (real time PCR). The real time PCR utilized in this study is a universal favivirus screen (reported previously) that targets the NS5 gene. In August 2010, a 3 year-old child was enrolled with clinical complaints of fever, headache, sore throat, and cough. Serological tests for dengue from both the acute and convalescent specimens were negative. The serum was positive by the favivirus screen but negative by dengue and Japanese Encephalitis specifc PCR tests. Nucleic acid sequencing of the amplicon isolated by gel purifcation produced a 100bp fragment with 100% sequence identity to Zika virus. This is the frst case of Zika virus identifed in Cambodia.",Embase,March 31, 2016,No,No full-text obtained yet,,,Scientific (journal) article,Yes,Original research,No,Yes,133,Clinical/epidemiological research,Case report
134,"Heang, Emerg Infect Dis, 2012",Heang,"Heang, V., Yasuda, C. Y., Sovann, L., Haddow, A. D., Travassos da Rosa, A. P., Tesh, R. B., Kasper, M. R.","Zika virus infection, Cambodia, 2010",Emerg Infect Dis,18,2,349-51,2012,2010-present,February 7, 2012,22305269,10.3201/eid1802.111224,1426,English,,,,,,,"Antibodies, Viral/blood, Cambodia, Child, Preschool, DNA, Viral/genetics, Humans, Male, Molecular Sequence Data, Molecular Typing, Sequence Analysis, DNA, Zika Virus/genetics/immunology/*isolation & purification, Zika Virus Infection/blood/*diagnosis/immunology/virology",,Pubmed,March 31, 2016,Yes,,No,"Zika, not relevant to causality framework",Scientific (journal) article,Yes,Original research,No,Yes,134,Clinical/epidemiological research,Case report
135,"Haddow, PLoS Negl Trop Dis, 2012",Haddow,"Haddow, A. D.; Schuh, A. J.; Yasuda, C. Y.; Kasper, M. R.; Heang, V.; Huy, R.; Guzman, H.; Tesh, R. B.; Weaver, S. C.",Genetic characterization of Zika virus strains: geographic expansion of the Asian lineage,PLoS Negl Trop Dis,6,2,e1477,2012,2010-present,March 6, 2012,22389730,10.1371/journal.pntd.0001477,1425,English,http://www.ncbi.nlm.nih.gov/pubmed/22389730,"Institute for Human Infections and Immunity, Center for Tropical Diseases, Department of Pathology, University of Texas Medical Branch, Galveston, Texas, USA. adhaddow@gmail.com",,,,,"Africa/epidemiology; Animals; Asia/epidemiology; Cluster Analysis; Genotype; Humans; Micronesia/epidemiology; Molecular Epidemiology; Molecular Sequence Data; *Phylogeography; RNA, Viral/genetics; Sequence Analysis, DNA; Zika Virus/*classification/*genetics/isolation & purification; Zika Virus Infection/epidemiology/*virology","BACKGROUND: Zika virus (ZIKV) is a mosquito-borne flavivirus distributed throughout much of Africa and Asia. Infection with the virus may cause acute febrile illness that clinically resembles dengue fever. A recent study indicated the existence of three geographically distinct viral lineages; however this analysis utilized only a single viral gene. Although ZIKV has been known to circulate in both Africa and Asia since at least the 1950s, little is known about the genetic relationships between geographically distinct virus strains. Moreover, the geographic origin of the strains responsible for the epidemic that occurred on Yap Island, Federated States of Micronesia in 2007, and a 2010 pediatric case in Cambodia, has not been determined. METHODOLOGY/PRINCIPAL FINDINGS: To elucidate the genetic relationships of geographically distinct ZIKV strains and the origin of the strains responsible for the 2007 outbreak on Yap Island and a 2010 Cambodian pediatric case of ZIKV infection, the nucleotide sequences of the open reading frame of five isolates from Cambodia, Malaysia, Nigeria, Uganda, and Senegal collected between 1947 and 2010 were determined. Phylogenetic analyses of these and previously published ZIKV sequences revealed the existence of two main virus lineages (African and Asian) and that the strain responsible for the Yap epidemic and the Cambodian case most likely originated in Southeast Asia. Examination of the nucleotide and amino acid sequence alignments revealed the loss of a potential glycosylation site in some of the virus strains, which may correlate with the passage history of the virus. CONCLUSIONS/SIGNIFICANCE: The basal position of the ZIKV strain isolated in Malaysia in 1966 suggests that the recent outbreak in Micronesia was initiated by a strain from Southeast Asia. Because ZIKV infection in humans produces an illness clinically similar to dengue fever and many other tropical infectious diseases, it is likely greatly misdiagnosed and underreported.",Pubmed,March 31, 2016,Yes,,No,"Zika, indirect evidence or other topic",Scientific (journal) article,Yes,Original research,No,Yes,135,Basic and applied biomedical research,Sequence analysis and phylogenetics
136,"Balm, J Med Virol, 2012",Balm,"Balm, M. N.; Lee, C. K.; Lee, H. K.; Chiu, L.; Koay, E. S.; Tang, J. W.",A diagnostic polymerase chain reaction assay for Zika virus,J Med Virol,84,9,1501-5,2012,2010-present,July 25, 2012,22825831,10.1002/jmv.23241,1424,English,http://www.ncbi.nlm.nih.gov/pubmed/22825831,"Division of Microbiology, Department of Laboratory Medicine, National University Hospital, Singapore.",,,,,"Adult; Female; Fever/diagnosis/virology; Genome, Viral; Humans; Limit of Detection; Male; *Molecular Diagnostic Techniques/standards; RNA, Viral/genetics/isolation & purification; Reference Standards; *Reverse Transcriptase Polymerase Chain Reaction/standards; Sequence Analysis, RNA; Singapore; Zika Virus/*genetics; Zika Virus Infection/*diagnosis/virology","Zika virus (ZIKV) is a mosquito-borne flavivirus. Infection results in a dengue-like illness with fever, headache, malaise, and a maculopapular rash. Nearly all cases are mild and self-limiting but in 2007, a large outbreak of ZIKV was reported from the island of Yap (in Micronesia, northwest of Indonesia). Singapore is already endemic for dengue, and its impact on public health and economic burden is significant. Other dengue-like infections (e.g., Chikungunya virus) are present. Yet only 10% of reported dengue cases have laboratory confirmation. The identification and control of other dengue-like, mosquito-transmitted infections is thus important for the health of Singapore's population, as well as its economy. Given that ZIKV shares the same Aedes mosquito vector with both dengue and Chikungunya, it is possible that this virus is present in Singapore and causing some of the mild dengue-like illness. A specific and sensitive one-step, reverse transcription polymerase chain reaction (RT-PCR) with an internal control (IC) was designed and tested on 88 archived samples of dengue-negative, Chikungunya-negative sera from patients presenting to our hospital with a dengue-like illness, to determine the presence of ZIKV in Singapore. The assay was specific for detection of ZIKV and displayed a lower limit of detection (LoD) of 140 copies viral RNA/reaction when tested on synthetic RNA standards prepared using pooled negative patient plasma. Of the 88 samples tested, none were positive for ZIKV RNA, however, the vast majority of these were from patients admitted to hospital and further study may be warranted in community-based environments.",Pubmed,March 31, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Original research,No,Yes,136,Basic and applied biomedical research,Other basic research
137,"Chastel, Bull Soc Pathol Exot, 2012",Chastel,"Chastel, C.",[When some Flaviviruses are throwing our certainties],Bull Soc Pathol Exot,105,4,251-5,2012,2010-present,August 28, 2012,22923343,10.1007/s13149-012-0255-8,1423,French,,chastelc@aol.com,,,,,"Africa/epidemiology, Americas/epidemiology, Animals, Asia/epidemiology, Australia/epidemiology, Climate Change, Commerce, Communicable Diseases, Emerging/*epidemiology/transmission/virology, Culicidae/virology, *Disease Outbreaks, Disease Reservoirs, Europe/epidemiology, Female, Flaviviridae/genetics/isolation & purification/*physiology, Flaviviridae Infections/*epidemiology/transmission/veterinary/virology, Global Health, Host Specificity, Humans, Insect Vectors/virology, Male, Micronesia/epidemiology, Travel","During the past two decades, a number of mosquito-borne flaviviruses, mainly of African origin, have invaded new geographical areas where they have never been active. This was the case for the Japanese encephalitis virus which reached the northeastern part of Australia (1995) and, above all, for the West Nile virus which, since 1999, entirely colonized the American continent. Then, the Usutu virus invaded a large part of the Western Europe (2001) while the Zika virus caused a large epidemic in an island of Micronesia (2007). Finally, in 2010, the Tembusu virus devastated many duck farms in China while the Bagaza virus, after having provoked human encephalitis in India, reached the southern part of Spain. In the affected areas, new pathogenic outcomes were observed in humans and animals while new vertebrate hosts and mosquito species were infected. Moreover, unusual ways of contamination were described. The origins of this unprecedented evolution remain to be clarified.",Pubmed,March 31, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,137,,
138,"Li, PLoS Negl Trop Dis, 2012",Li,"Li, M. I., Wong, P. S., Ng, L. C., Tan, C. H.",Oral susceptibility of Singapore Aedes (Stegomyia) aegypti (Linnaeus) to Zika virus,PLoS Negl Trop Dis,6,8,e1792,2012,2010-present,September 7, 2012,22953014,10.1371/journal.pntd.0001792,1422,English,,"Environmental Health Institute, National Environment Agency, Singapore, Singapore.",,,,,"Aedes/*virology, Animals, Digestive System/virology, *Disease Vectors, Female, Singapore, Zika Virus/*pathogenicity, Zika Virus Infection/transmission/virology","BACKGROUND: Zika virus (ZIKV) is a little known flavivirus that caused a major outbreak in 2007, in the South-western Pacific Island of Yap. It causes dengue-like syndromes but with milder symptoms. In Africa, where it was first isolated, ZIKV is mainly transmitted by sylvatic Aedes mosquitoes. The virus has also been isolated from Ae. aegypti and it is considered to be the vector involved in the urban transmission of the virus. Transmission of the virus by an African strain of Ae. aegypti has also been demonstrated under laboratory conditions. The aim of the present study is to describe the oral susceptibility of a Singapore strain of Ae. aegypti to ZIKV, under conditions that simulate local climate. METHODOLOGY/PRINCIPAL FINDINGS: To assess the receptivity of Singapore's Ae. aegypti to the virus, we orally exposed a local mosquito strain to a Ugandan strain of ZIKV. Upon exposure, fully engorged mosquitoes were maintained in an environmental chamber set at 29 degrees C and 70-75% RH. Eight mosquitoes were then sampled daily from day 1 to day 7, and subsequently on days 10 and 14 post exposure (pe). The virus titer of the midgut and salivary glands of each mosquito were determined using a tissue culture infectious dose(50) (TCID(50)) assay. High midgut infection and salivary gland dissemination rates were observed. By day 5 after the infectious blood meal, ZIKV was found in the salivary glands of more than half of the mosquitoes tested (62%); and by day 10, all mosquitoes were potentially infective. CONCLUSIONS/SIGNIFICANCE: This study showed that Singapore's urban Ae. aegypti are susceptible and are potentially capable of transmitting ZIKV. The virus could be established in Singapore should it be introduced. Nevertheless, Singapore's current dengue control strategy is applicable to control ZIKV.",Pubmed,March 31, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Original research,No,Yes,138,Environmental and vector research,Vector competence studies
139,"Crockett, Am J Trop Med Hyg, 2012",Crockett,"Crockett, R. J., Gilbert, A., Kityo, R., Ledermann, J., Borland, E., Powers, A., Panella, N., Crabtree, M., Nakayiki, T., Kuzmin, I., Niezgoda, M., Agwanda, B., Markotter, W., Malekani, J., Kalemba, L., Akaibe, D., Rupprecht, C., Lutwama, J., Miller, B.","Arbovirus surveillance and virus isolations from bats in Uganda, Kenya, and the democratic republic of the Congo",Am J Trop Med Hyg,1),,170,2012,2010-present,,71041195,,1665,English,"http://www.ajtmh.org/content/87/5_Suppl_1/150.full.pdf+html, http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emed10&AN=71041195","(Crockett, Ledermann, Borland, Powers, Panella, Crabtree, Miller) Centers for Disease Control and Prevention, Fort Collins, CO, United States (Gilbert, Kuzmin, Niezgoda, Rupprecht) Centers for Disease Control and Prevention, Atlanta, GA, United States (Kityo) Makerere University, Kampala, Uganda (Nakayiki, Lutwama) Uganda Virus Research Institute, Entebbe, Uganda (Agwanda) National Museum of Kenya, Nairobi, Kenya (Markotter) University of Pretoria, Pretoria, South Africa (Malekani, Kalemba) University of Kinshasa, Kinshasa, Democratic Republic Congo (Akaibe) University of Kisangani, Kisangani, Democratic Republic Congo, R.J. Crockett, Centers for Disease Control and Prevention, Fort Collins, CO, United States",,,,,"virus isolation, Uganda, Kenya, Democratic Republic Congo, society, tropical medicine, hygiene, Arbovirus, virus, Flavivirus, spleen, liver, species, Africa, fruit, human, Vero cell, chikungunya, yellow fever, pathogenesis, immunofluorescence test, blood, serodiagnosis, tissues, Rift Valley fever, dengue, serum, exposure, diseases, neutralizing antibody, tissue culture medium","Zoonotic and vector-borne pathogens have comprised a significant component of emerging human diseases in recent decades. Arboviruses including Rift Valley fever (RVFV), Yellow fever (YFV), West Nile (WNV), Chikungunya (CHIKV) and Zika viruses have been isolated or detected serologically from various East African bat species, however the role of bats in arbovirus transmission cycles is poorly understood. The aim of this study was to investigate the exposure history of bats in East Africa to arboviruses as well as attempt virus isolation from bat tissues. Blood, liver, and spleen samples were collected from 281 bats from Uganda, 449 bats from Kenya, and 239 bats from the Democratic Republic of the Congo during 2011-2012. Liver and/or spleen samples from each bat were mechanically homogenized in tissue culture media and virus isolation was performed on Vero cells. Virus isolates were identified by either RTPCR using virus group-specific primers, or by immunofluorescence assay. When available, serum samples were tested for neutralizing antibodies against WNV, YFV, Dengue 2 (DENV-2) virus, CHIKV, O'nyong-nyong virus, Babanki virus and RVFV by plaque reduction neutralization test. Virus isolates include Entebbe bat virus (Flaviviridae: Flavivirus) from Chaerephon pumila from Uganda, and as yet unidentified viruses from Hipposideros commersoni and Triaenops persicus in Kenya. Epomophorus labiatus fruit bats from Uganda demonstrated neutralizing antibodies against Babanki virus (1/33, 3%), RVFV (3/33, 9%), and flaviviruses (2/33, 6%). Flavivirus neutralizing antibodies were also found in C. pumila and Mops condylura from Uganda. Serological and virological evidence suggest that multiple species of fruit and insectivorous bats from East Africa are exposed to and are incidental or potential amplification hosts for arboviruses.",Embase,March 31, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Original research,No,Yes,139,Environmental and vector research,Ecological/animal cross-sectional
140,"Lukindu, Am J Trop Med Hyg, 2012",Lukindu,"Lukindu, M., Mukwaya, L. G., Masembe, C., Birungi, J.",Changing behavioral patterns of arboviral vector aedes africanus: A concern for emerging and reemerging diseases,Am J Trop Med Hyg,1),,419,2012,2010-present,,71042015,,1664,English,"http://www.ajtmh.org/content/87/5_Suppl_1/378.full.pdf+html, http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emed10&AN=71042015","(Lukindu, Masembe) Makerere University Kampala, Kampala, Uganda (Mukwaya, Birungi) Uganda Virus Research Institute, Entebbe, Uganda, M. Lukindu, Makerere University Kampala, Kampala, Uganda",,,,,"Aedes, diseases, society, tropical medicine, hygiene, forest, human, Africa, hemorrhagic fever, mosquito, tree, maturity, vector control, dengue, bamboo, Rift Valley fever, epidemic, yellow fever, Arbovirus, landscape, primate, height, canopy, human activities, virus, vaccine, steel, water","Aedes (Stegomyia) africanus Theobald is a key arboviral vector to humans. It is a highly competent vector for several viruses that cause hemorrhagic fevers including; Yellow fever (YF), Rift Valley fever, dengue fever, and other arboviral vectors, most of which are widely distributed in Africa. There are no vaccines for these arboviral diseases except YF which has a safe and effective vaccine, yet YF outbreaks are still reported in Africa. Vector control is therefore crucial yet little is known about the biology of Ae africanus to enable effective vector targeted control and management of hemorrhagic fevers. Aedes africanus has specific behavioral preferences, some of which facilitate their spread within the rapidly changing landscape of Africa. Ae. africanus is reportedly confined to forests. However, it was implicated in the peridomestic transmission of YF to humans during the 1987 Nigerian YF epidemic. This study aims to understand the behavior of Ae. africanus. Bamboo pots containing water were placed on a 120 feet steel tower in Zika forest, Entebbe. The pots were placed at ground level, platforms at 20, 40, 60, 80, 100 feet above the ground and at shaded spots of the encroached forest buffer zone. Immature samples were collected weekly, reared to maturity and morphologically identified. After 32 weeks, a total of 734 mosquitoes were collected inside the forest 89% of which were collected at 60 feet and below. A total of 642 Ae. africanus mosquitoes were collected at 200 and 400 feet from the forest boundary. These results indicate that Ae. africanus prefers to oviposit at levels below the tree canopy. These are shaded areas in the forest and heights at which the host, primates, are found. There is also a tendency for a change from a sylvatic (forest confinement) to a peridomestic behavior. This is probably due to the increased human activities in the forest buffer zone. Encroachment on the forest buffer zone must be strongly discouraged given previous isolations of several arboviruses from the forest, most of which have been isolated in Ae. africanus.",Embase,March 31, 2016,No,Unrelated to Zika virus,,,Scientific (journal) article,Yes,Original research,No,Yes,140,Environmental and vector research,Ecological/animal cross-sectional
141,"Rios, Vox Sanguinis, 2012",Rios,"Rios, M., An ez, G., Chancey, C., Grinev, A.",Dengue virus and other arboviruses: A global view of the risks,Vox Sanguinis,103,,62-63,2012,2010-present,,71015881,http://dx.doi.org/10.1111/j.1423-0410.2012.01615-1.x,1668,English,http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emed10&AN=71015881,"(Rios, An ez, Chancey, Grinev) US Food and Drug Administration/CBER/OBRR, Bethesda, MD, United States, M. Rios, US Food and Drug Administration/CBER/OBRR, Bethesda, MD, United States",,,,,"Arbovirus, risk, society, blood transfusion, Dengue virus, infection, blood, human, tick borne encephalitis, recipient, virus, virus infection, diseases, epidemic, screening test, Western Hemisphere, invertebrate, flu like syndrome, malaise, cognitive defect, plasticity, togavirus, yellow fever, Chikungunya alphavirus, tick, blood component, west nile flavivirus, Flavivirus, vascularization, safety, mosquito, virus replication, incubation time, population, telecommunication, assay, St. Louis encephalitis, species, screening, mortality, fever, Rift Valley fever, Murray Valley encephalitis, Japanese encephalitis, alertness, diagnosis, vertebrate, arthropod, sensitivity and specificity, therapy, travel, Bunyavirus, vaccine, antivirus agent","Arboviruses (arthropod-borne viruses) are an ecological group of viruses from different families (e.g. Bunyaviridae, Flaviviridae and Togaviridae) that use arthropods such as mosquitoes, flies and ticks as vectors for transmission between different hosts. The superb plasticity of these viruses allows propagation to different host systems including both invertebrates and vertebrates. More than 500 species of arboviruses have been described and are listed in the international Catalogue of Arboviruses (http: //www.cdc.gov/nczved/divisions/dvbid/arbovirus.html), many of which are of medical importance. Globally, arbovirus infections have become increasingly common and human diseases caused by arbovirus infections have expanded their frontiers in the last few decades emerging in places with no previous history of epidemic activity or localized transmission of a specific arbovirus. One example is the recent arrival of the West Nile virus (WNV) in the Western Hemisphere and its subsequent propagation in the Americas. Arboviral diseases are also re-emerging in places where the disease had previously been well-controlled or eradicated, resulting in an increasing number of cases and more severe forms of disease in endemic regions. Human infections with arboviruses are mostly asymptomatic but symptomatic infections can range from malaise, mild febrile illness (with flu-like symptoms) to severe disease that progresses to long-term physical or cognitive impairment and/or mortality. For most arboviruses, there is neither vaccine nor specific antiviral treatment currently available. Arboviral infections, like other viral infections, have an incubation period during which viral replication with a viremic phase takes place in the absence of symptoms. Moreover, a large proportion of human infections by most arboviruses remain asymptomatic until the body clears the viruses from circulation. Viremic blood has the potential to transmit infection to blood recipients and therefore arboviruses can pose a threat to the safety of the blood supply. For instance, during an epidemic, asymptomatic individuals may donate blood and, in the absence of blood screening tests, transmit the infection to blood component recipients. Among the arboviral infections that have been on the radar for increased activity in the last decade are: WNV, Dengue viruses (DENV) and Chikungunya virus (CHIKV). In addition, other arboviral infections such as Yellow Fever, Saint Louis encephalitis, Tick-borne encephalitis, Rift Valley fever, Japanese encephalitis, Powassan, Murray Valley encephalitis and Zika fever have been reported as emerging or re-emerging in various areas around the globe. Alertness and surveillance are required to allow implementation of measures to mitigate risk of transmission to blood recipients including blood screening tests when available and appropriate. In addition, the evidence of increased arbovirus activity worldwide points to the critical need for development of affordable diagnostic and screening assays with high sensitivity and specificity as well as new vaccines and therapies, since most populations at risk reside in less privileged parts of the world. The need for these tools is pressed by the imminent possibility of outbreaks in any part of the world due to the combination of expanding distribution of vectors and increased mobility of infected hosts by travel and trade.",Embase,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Yes,Review,No,Yes,141,Clinical/epidemiological research,Epidemiological/clinical review
142,"Kilpatrick, Lancet, 2012",Kilpatrick,"Kilpatrick, A. M.; Randolph, S. E.","Drivers, dynamics, and control of emerging vector-borne zoonotic diseases",Lancet,380,9857,1946-55,2012,2010-present,,23200503,10.1016/S0140-6736(12)61151-9,1903,,http://www.ncbi.nlm.nih.gov/pubmed/23200503,"Department of Ecology and Evolutionary Biology, University of California, Santa Cruz, Santa Cruz, CA 95064, USA. akilpatr@ucsc.edu",,,,,"Animals; Blood-Borne Pathogens; Climate Change; Communicable Diseases, Emerging/epidemiology/*prevention & control/transmission; *Disease Vectors; Global Health; Humans; Incidence; Risk Factors; Socioeconomic Factors; Tick Infestations/epidemiology; Zoonoses/*epidemiology","Emerging vector-borne diseases are an important issue in global health. Many vector-borne pathogens have appeared in new regions in the past two decades, while many endemic diseases have increased in incidence. Although introductions and emergence of endemic pathogens are often considered to be distinct processes, many endemic pathogens are actually spreading at a local scale coincident with habitat change. We draw attention to key differences between dynamics and disease burden that result from increased pathogen transmission after habitat change and after introduction into new regions. Local emergence is commonly driven by changes in human factors as much as by enhanced enzootic cycles, whereas pathogen invasion results from anthropogenic trade and travel where and when conditions (eg, hosts, vectors, and climate) are suitable for a pathogen. Once a pathogen is established, ecological factors related to vector characteristics can shape the evolutionary selective pressure and result in increased use of people as transmission hosts. We describe challenges inherent in the control of vector-borne zoonotic diseases and some emerging non-traditional strategies that could be effective in the long term.",Lancet,March 31, 2016,No,Unrelated to Zika virus,,,Scientific (journal) article,Yes,Review,No,Yes,142,Environmental and vector research,Ecological/Vector review
143,"Shah, F1000Res, 2012",Shah,"Shah, K. V.; Dandawate, C. N.; Bhatt, P. N.",Kyasanur forest disease virus: viremia and challenge studies in monkeys with evidence of cross-protection by Langat virus infection,F1000Res,1,,61,2012,2010-present,,24627765,10.12688/f1000research.1-61.v1,1843,,http://www.ncbi.nlm.nih.gov/pubmed/24627765,"Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, 21205, USA.; National Institute of Virology, Pune, MH 411001, India.; Section of Comparative Medicine, Yale University School of Medicine, New Haven, CT, 06520, USA.",,,,,,"Kyasanur Forest Disease Virus (KFDV), discovered in 1957, is a member of the tick-borne encephalitis virus (TBEV) complex. Diseases caused by members of the TBEV complex occur in many parts of the world. KFDV produces a hemorrhagic fever in humans in South India and fatal illnesses in both species of monkeys in the area, the black faced langur (Presbytis entellus) and the bonnet macaque (Macaca radiata). Experimental infection of the langur and the bonnet macaque with early mouse passage KFDV strain P9605 resulted in a viremia of up to 11 days duration, peak viremia titers as high as 10 (9), and death in 82 = 100% of the animals. Prolonged passage of the KFDV strain P9605 in monkey kidney tissue culture resulted in a markedly reduced virulence of the virus for both species; peak viremia titers in monkeys decreased by 2.5 to 4.0 log LD 50 (p= 0.001), and the mortality decreased to 10% (p= 0.001). In challenge experiments, monkeys previously infected with tissue-culture-adapted KFDV, or with the related Langat virus from Malaysia, were fully protected against virulent KFDV. These studies in non-human primates lend support to the idea that a live virus vaccine from a member of the TBEV complex may be broadly protective against infections by other members of the TBEV complex.",F1000,March 31, 2016,No,Unrelated to Zika virus,,,Scientific (journal) article,Yes,Original research,No,Yes,143,Basic and applied biomedical research,Animal experiment
144,"Ofula, Am J Trop Med Hyg, 2012",Ofula,"Ofula, V. O., Oundo, J., Irura, Z., Chepkorir, E., Tigoi, C., Ongus, J., Schoepp, R., Rossi, C., Wurapa, E. K., Sonde, H., Sang, R.","Seroprevalence of selected arboviruses in ijara and marigat districts, Kenya",Am J Trop Med Hyg,1),,126,2012,2010-present,,71041050,,1666,English,"http://www.ajtmh.org/content/87/5_Suppl_1/75.full.pdf+html, http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emed10&AN=71041050","(Ofula, Wurapa) United States Army Medical Research Unit-Kenya, Nairobi, Kenya (Oundo) Centers for Disease Control, Prevention-Kenya, Nairobi, Kenya (Irura) Ministry of Public Health and Sanitation, Nairobi, Kenya (Chepkorir, Tigoi) International Center for Insect Physiology and Ecology, Nairobi, Kenya (Ongus) Jomo Kenyatta University, Agriculture and Technology, Nairobi, Kenya (Schoepp, Rossi) U.S. Army Medical Research, Institute for Infectious Diseases, Frederick, MD, United States (Sonde) Ministry of Medical Services, Ijara, Kenya (Sang) Kenya Medical Research Institute, Nairobi, Kenya, V.O. Ofula, United States Army Medical Research Unit-Kenya, Nairobi, Kenya",,,,,"seroprevalence, Arbovirus, Kenya, society, tropical medicine, hygiene, human, virus, Psychodidae, population, patient, chikungunya, serum, Uganda, dengue, mosquito, species, Africa, Culex, prevalence, blood, Anopheles, male, Aedes, public health, industrialization, tick, west nile flavivirus, documentation, female, exposure, arthropod, antibody, immunoglobulin G","Arboviruses are transmitted by arthropods; humans become infected during blood meal by infected mosquitoes, ticks and sandflies. Arboviruses have been well characterized in many industrialized countries, but there are many knowledge gaps in developing nations. Entomological surveys conducted so far have demonstrated circulation of arboviruses of significant public health importance in Aedes, Anopheles and Culex species in vast populations in Kenya, suggesting the presence of competent vector systems for many of the arboviruses. The human population involvement in the transmission of these viruses has however not been demonstrated. This study sought to determine the seroprevalence of a range of arboviruses including Chikungunya, Dengue, Sindbis, Sandfly Naples, Sandfly Sicilian, Uganda S, West Nile and Zika viruses in Ijara and Marigat. About 5mul of patients' serum samples was used to test for antibodies to each of the viruses listed. All the samples were tested by IgG ELISA.A total of 351 patient serum samples were analyzed, of these 193 (54.9%) were male while female were 158 (45.1%), and age range was between 3 and 73. The overall positivity for the arboviruses was 53/351 (15.1%). The arboviruses prevalence in Marigat was 7% (10/143) while Ijara was 21% (43/208). Uganda S virus was the most prevalent with 10%, followed by West Nile virus 6%, Sindbis 5%, Dengue 2%, Chikungunya 1.1%, Sandfly Naples 0.2%. Antibodies against Sandfly Sicilian and Zika viruses were not detected. This is the first documentation of antibodies against Sandfly Naples virus in the sub-Sahara Africa. This study has shown the evidence of past exposure of the selected arboviruses in human population in the two sites. This information together with vectors data will strengthen efforts to develop focused preventive actions to stop transmission and create awareness among clinicians to help improve patients' management in the region.",Embase,March 31, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Original research,No,Yes,144,Clinical/epidemiological research,Cross-sectional study
145,"Antonjaya, Am J Trop Med Hyg, 2012",Antonjaya,"Antonjaya, U.","Study of arboviruses in archived specimens from acute febrile illness studies in bandung,Indonesia",Am J Trop Med Hyg,1),,122,2012,2010-present,,71041038,,1667,English,"http://www.ajtmh.org/content/87/5_Suppl_1/75.full.pdf+html, http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emed10&AN=71041038","(Antonjaya) Eijkman-Oxford Clinical Research Unit, Jakarta, Indonesia, U. Antonjaya, Eijkman-Oxford Clinical Research Unit, Jakarta, Indonesia",,,,,"diseases, Indonesia, society, tropical medicine, hygiene, Arbovirus, virus, dengue, infection, Japanese encephalitis virus, west nile flavivirus, human, pathogenesis, assay, Ross River alpha virus, Chikungunya alphavirus, developing country, chikungunya, public health, Flavivirus, etiology, hospital, patient, pandemic, gold standard, risk, virus isolation, DNA sequence, immunoglobulin M, dna","Numerous recent arboviral outbreaks have demonstrated that arthropodborne pathogens continue to be significant public health threats. These outbreaks have not been limited to tropical or developing countries as people and goods can be moved anywhere in the world within days. Indonesia might be a very important country for emerging viruses having several endemic arboviruses including dengue, chikungunya, and Japanese encephalitis viruses. Outbreaks due to these viruses have occurred several times in Indonesia but to date studies on the existence of other arboviruses in Indonesia are scarce. Therefore, a study to detect evidence of arboviral pathogens in archived samples is currently in progress. The main purpose of this project is to identify the presence of emerging arboviruses of pandemic risk in Indonesia. We have identified archived samples from prior acute febrile infection studies that enrolled patients in two hospitals in Bandung, West Java, Indonesia from 2004-2005. The original study enrolled a total of 406 hospitalized suspect-dengue cases; the majority (311) had evidence of recent dengue infection. However, infecting etiologies on the remaining samples had not been determined. The current study includes testing for other specific endemic arboviruses as well as unknown arboviruses in the dengue negative samples. Initially, samples are tested against panels of several arboviruses including flaviviruses, alphaviruses, and bunyaviruses employing RT-PCR and IgM detection assays. Suspect positive samples are further tested with virus specific RT-PCR, viral isolation, and DNA sequencing targeting several viruses including Japanese encephalitis virus, West Nile virus, Zika virus, Chikungunya virus, Ross River virus, and hantaviruses. Our study is the first systemic survey on emerging viruses in Indonesia with gold standard molecular, serological, and virus isolation assays to estimate the magnitude of circulation of arboviruses.",Embase,March 31, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Original research,No,Yes,145,Clinical/epidemiological research,Cross-sectional study
146,"Kwong, Am J Trop Med Hyg, 2013",Kwong,"Kwong, J. C., Druce, J. D., Leder, K.",Zika virus infection acquired during brief travel to Indonesia,Am J Trop Med Hyg,89,3,516-7,2013,2010-present,July 24, 2013,23878182,10.4269/ajtmh.13-0029,1421,English,,"Victorian Infectious Diseases Service, The Royal Melbourne Hospital, Melbourne, Victoria, Australia. kwongj@gmail.com",,,,,"Australia, Exanthema/etiology/virology, Female, Fever/etiology/virology, Humans, Indonesia, Middle Aged, RNA, Viral/blood/*isolation & purification, Travel, Zika Virus/*isolation & purification, Zika Virus Infection/blood/complications/*diagnosis",Zika virus infection closely resembles dengue fever. It is possible that many cases are misdiagnosed or missed. We report a case of Zika virus infection in an Australian traveler who returned from Indonesia with fever and rash. Further case identification is required to determine the evolving epidemiology of this disease.,Pubmed,March 31, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Original research,No,Yes,146,Clinical/epidemiological research,Case report
147,"Wong, PLoS Negl Trop Dis, 2013",Wong,"Wong, P. S.; Li, M. Z.; Chong, C. S.; Ng, L. C.; Tan, C. H.",Aedes (Stegomyia) albopictus (Skuse): a potential vector of Zika virus in Singapore,PLoS Negl Trop Dis,7,8,e2348,2013,2010-present,August 13, 2013,23936579,10.1371/journal.pntd.0002348,1420,English,http://www.ncbi.nlm.nih.gov/pubmed/23936579,"Environmental Health Institute, National Environment Agency, Singapore, Singapore.",,,,,Aedes/*virology; Animals; Female; Gastrointestinal Tract/virology; *Insect Vectors; Real-Time Polymerase Chain Reaction; Saliva/virology; Salivary Glands/virology; Singapore; Viral Load; *Zika Virus/isolation & purification/pathogenicity; Zika Virus Infection/transmission/*virology,"BACKGROUND: Zika virus (ZIKV) is a little known arbovirus until it caused a major outbreak in the Pacific Island of Yap in 2007. Although the virus has a wide geographic distribution, most of the known vectors are sylvatic Aedes mosquitoes from Africa where the virus was first isolated. Presently, Ae. aegypti is the only known vector to transmit the virus outside the African continent, though Ae. albopictus has long been a suspected vector. Currently, Ae. albopictus has been shown capable of transmitting more than 20 arboviruses and its notoriety as an important vector came to light during the recent chikungunya pandemic. The vulnerability of Singapore to emerging infectious arboviruses has stimulated our interest to determine the competence of local Ae. albopictus to transmit ZIKV. METHODOLOGY/PRINCIPAL FINDINGS: To determine the competence of Ae. albopictus to ZIKV, we orally infected local mosquito strains to a Ugandan strain virus. Fully engorged mosquitoes were maintained in an environmental chamber set at 29 degrees C and 80-85%RH. Twelve mosquitoes were then sampled daily from day one to seven and on day 10 and 14 post infection (pi). Zika virus titre in the midgut and salivary glands of each mosquito were determined using tissue culture infectious dose50 assay, while transmissibility of the virus was determined by detecting viral antigen in the mosquito saliva by qRT-PCR. High dissemination and transmission rate of ZIKV were observed. By day 7-pi, all mosquitoes have disseminated infection and 73% of these mosquitoes have ZIKV in their saliva. By day 10-pi, all mosquitoes were potentially infectious. CONCLUSIONS/SIGNIFICANCE: The study highlighted the potential of Ae. albopictus to transmit ZIKV and the possibility that the virus could be established locally. Nonetheless, the threat of ZIKV can be mitigated by existing dengue and chikungunya control program being implemented in Singapore.",Pubmed,March 31, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Original research,No,Yes,147,Environmental and vector research,Vector competence studies
148,"Faye, Virol J, 2013",Faye,"Faye, O., Faye, O., Diallo, D., Diallo, M., Weidmann, M., Sall, A. A.",Quantitative real-time PCR detection of Zika virus and evaluation with field-caught mosquitoes,Virol J,10,,311,2013,2010-present,October 24, 2013,24148652,10.1186/1743-422x-10-311,1419,English,,"Unite des Arbovirus et virus de fievres hemorragiques, Institut Pasteur Dakar, 36, Avenue Pasteur, BP 220 Dakar, Senegal. asall@pasteur.sn.",,,,,"Animals, Culicidae/virology, Molecular Diagnostic Techniques/*methods, Real-Time Polymerase Chain Reaction/*methods, Sensitivity and Specificity, Time Factors, Zika Virus/genetics/*isolation & purification, *Zika Virus Infection/diagnosis/virology","BACKGROUND: Zika virus (ZIKV), a mosquito borne flavivirus is a pathogen affecting humans in Asia and Africa. ZIKV infection diagnosis relies on serology-which is challenging due to cross-reactions with other flaviviruses and/or absence or low titer of IgM and IgG antibodies at early phase of infection- virus isolation, which is labor intensive, time consuming and requires appropriate containment. Therefore, real-time RT-PCR (rRT-PCR) is an appealing option as a rapid, sensitive and specific method for detection of ZIKV in the early stage of infection. So far, only one rRT-PCR assay has been described in the context of the outbreak in Micronesia in 2007. In this study, we described a one step rRT-PCR for ZIKV which can detect a wider genetic diversity of ZIKV isolates from Asia and Africa. RESULTS: The NS5 protein coding regions of African ZIKV isolates were sequenced and aligned with representative flaviviruses sequences from GenBank to design primers and probe from conserved regions. The analytical sensitivity of the assay was evaluated to be 32 genome-equivalents and 0.05 plaque forming unit (pfu). The assay was shown to detect 37 ZIKV isolates covering a wide geographic in Africa and Asia over 36 years but none of the 31 other flaviviruses tested showing high analytical specificity. The rRT-PCR could be performed in less than 3 hours. This method was used successfully to detect ZIKV strains from field-caught mosquitoes. CONCLUSION: We have developed a rapid, sensitive and specific rRT-PCR for detection of ZIKV. This assay is a useful tool for detection of ZIKV infection in regions where a number of other clinically indistinguishable arboviruses like dengue or chikungunya co-circulate. Further studies are needed to validate this assay in clinical positive samples collected during acute ZIKV infection.",Pubmed,March 31, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Original research,No,Yes,148,Basic and applied biomedical research,Other basic research
149,"Ofula, Am J Trop Med Hyg, 2013",Ofula,"Ofula, V. O., Oundo, J., Irura, Z., Chepkorir, E., Tigoi, C., Lwande, O., Ongus, J., Schoepp, R., Rossi, C., Wurapa, E. K., Sonde, H., Sang, R.","Evidence of circulation of selected arboviruses in ijara and marigat districts, Kenya",Am J Trop Med Hyg,1),,278,2013,2010-present,,71312750,,1660,English,"http://www.ajtmh.org/content/89/5_Suppl_1/228.full.pdf+html, http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emed11&AN=71312750","(Ofula, Wurapa) United States Army Medical Research Unit-Kenya, Nairobi, Kenya (Oundo) United States Army Medical Research Unit-Kenya, Kericho, Kenya (Irura) Ministry of Health, Nairobi, Kenya (Chepkorir, Tigoi, Lwande) International Centre for Insect Physiology and Ecology, Nairobi, Kenya (Ongus) Jomo Kenyatta University of Agriculture and Technology, Juja, Kenya (Schoepp, Rossi) United States Army Medical Research Institute for Infectious Diseases, Fort Detrick, MD, United States (Sonde) Ministry of Health, Ijara, Kenya (Sang) Kenya Medical Research Institute, Nairobi, Kenya, V.O. Ofula, United States Army Medical Research Unit-Kenya, Nairobi, Kenya",,,,,"Kenya, society, tropical medicine, hygiene, Arbovirus, human, Psychodidae, virus, prevalence, population, dengue, public health, Uganda, chikungunya, arthropod, seroprevalence, tick, Semliki Forest alphavirus, mosquito, species, serodiagnosis, male, Flavivirus, Culex, feeding, Anopheles, serum, blood, female, patient, Alpha virus, Bunyavirus, West Nile flavivirus, Aedes, industrialization, hospital patient, enzyme linked immunosorbent assay, antibody, immunoglobulin G","Arboviruses are transmitted by arthropods with humans becoming infected during blood feeding by infected mosquitoes, ticks and sandflies. Characterization of arbovirus circulation and transmission in industrialized countries has been well documented, but there are many knowledge gaps in developing nations. Entomological surveys conducted so far have indicated circulation of arboviruses of significant public health importance in Aedes, Anopheles and Culex species in vast populations in Kenya, suggesting the presence of competent vector systems. The human involvement in the transmission cycle of these viruses has however not been demonstrated. This study sought to determine the sero-prevalence of a range of arboviruses including; Chikungunya, Dengue, Sindbis, Sandfly Naples, Sandfly Sicilian, Uganda S, West Nile and Zika viruses in Ijara and Marigat Districts where vector surveillance has been done. A total of 351 patient serum samples were analyzed using IgG ELISA, of these 193 (54.9%) were male and 158 (45.1%) were female with age ranging between 3 and 73. The overall arbovirus prevalence was 53/351 (15.1%) with a prevalence of 7% (10/143) in Marigat and 21% (43/208) in Ijara. Of the positives, Flaviviruses were 69%, alpha viruses 29.6% and Bunyaviridae 1.4%. Uganda S virus was the most prevalent with 10%, followed by West Nile virus 6%, Sindbis 5%, Dengue 2%, Chikungunya 1.1%, Sandfly Naples 0.2% respectively. Semliki-forest virus-specific antibodies were detected by plaque reduction neutralization test in 3/351 (0.85%) persons tested. Antibodies against Sandfly Sicilian and Zika viruses were not detected. This study constitutes the first detection of antibodies against Sandfly Naples virus in Kenya. The study has demonstrated the circulation of the selected arboviruses in the two sites amongst human population. These findings will improve our understanding of impact of Arboviruses on public health in the regions so that preventive actions and awareness among clinicians in patient' recognition and management can be enhanced.",Embase,March 31, 2016,No,Duplicate of existing record,,,,,,,,,,
150,"Kaddumukasa, Am J Trop Med Hyg, 2013",Kaddumukasa,"Kaddumukasa, M. A., Kayondo, J. K., Akol, A. M., Masiga, D., Lutwama, J. J., Masembe, C.","Human encroachment on forests may increase exposure to new mosquito species and pathogens evidence from Zika Forest, Uganda",Am J Trop Med Hyg,1),,337,2013,2010-present,,71312942,,1659,English,"http://www.ajtmh.org/content/89/5_Suppl_1/304.full.pdf+html, http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emed11&AN=71312942","(Kaddumukasa, Akol, Masembe) Makerere University, Kampala, Uganda (Kayondo, Lutwama) Uganda Virus Research Institute, Entebbe, Uganda (Masiga) International Centre for Insect Physiology and Ecology (ICIPE), African Insect Science for Food and Health, Nairobi, Kenya, M.A. Kaddumukasa, Makerere University, Kampala, Uganda",,,,,"human, forest, mosquito, tropical medicine, species, Uganda, pathogenesis, society, hygiene, exposure, blood, mammal, meal, bird, Amphibia, host, risk, animal community, reptile, environmental change, GenBank, Arbovirus, Kruskal Wallis test, public health, diseases, prevention and control, wildlife, cytochrome c oxidase, cytochrome","The steady increase in contact between humans and wildlife is brought about by human encroachment, destruction of natural forests and environmental changes. Mosquitoes get exposed to new hosts and pathogens; creating possibilities for new disease patterns. Therefore identification of blood meal sources is important to determine the interaction between hosts and vectors. In this work, engorged mosquitoes were collected in Zika forest (Uganda) for a period of 12 months, and abdominal contents sequenced for cytochrome oxidase subunit I and cytochrome b. The sequences were subsequently blast searched in Genbank and the analyses revealed the presence of mammalian (86%), avian (13%) and amphibian-derived (1%) hosts. The first record of human origin blood-meals from Uranotaenia species in Zika Forest was shown. Earlier studies showed these species to feed exclusively on reptiles, amphibians, birds or domestic mammals. Taking of mammalian origin blood-meals puts the human and entire animal community at risk because of the possibility of exposure to new pathogens. Significant differences between host species were observed (Kruskal Wallis test, chi<sup>2</sup> = 19.118, df = 5, p = 0.018) suggesting a wide range of host exposure. This could possibly create new disease patterns. Several mosquitoes may be considered potential bridge vectors for a number of arboviruses from the composition of their blood-meals. These results highlight the public health significance of taking measures to avoid encroachment of forests and reserves for diseases prevention and control.",Embase,March 31, 2016,No,Unrelated to Zika virus,,,Scientific (journal) article,Yes,Original research,No,Yes,150,Environmental and vector research,Ecological/animal cross-sectional
151,"Brust, IDCases, 2014",Brust,"Brust, K. B., Prince, W. S., Fader, R. C.",Trouble in paradise,IDCases,1,4,95-6,2014,2010-present,January 1, 2014,26839785,10.1016/j.idcr.2014.10.009,1418,English,,"Division of Infectious Diseases, Baylor Scott & White Healthcare, Texas A&M Health Science Center College of Medicine, Temple, TX, USA., Division of Pulmonary, Baylor Scott & White Healthcare, Texas A&M Health Science Center College of Medicine, Temple, TX, USA., Division of Microbiology, Baylor Scott & White Healthcare, Temple, TX, USA.",,,,,"Fever in a traveler, Flavivirus, Outbreak, Zika fever",,Pubmed,March 31, 2016,Yes,,No,"Zika, not relevant to causality framework",Scientific (journal) article,Yes,Original research,No,Yes,151,Clinical/epidemiological research,Case report
152,"Faye, PLoS Negl Trop Dis, 2014",Faye,"Faye, O.; Freire, C. C.; Iamarino, A.; Faye, O.; de Oliveira, J. V.; Diallo, M.; Zanotto, P. M.; Sall, A. A.",Molecular evolution of Zika virus during its emergence in the 20(th) century,PLoS Negl Trop Dis,8,1,e2636,2014,2010-present,January 15, 2014,24421913,10.1371/journal.pntd.0002636,1417,English,http://www.ncbi.nlm.nih.gov/pubmed/24421913,"Institut Pasteur de Dakar, Dakar, Senegal.; Laboratory of Molecular Evolution and Bioinformatics, Department of Microbiology, Biomedical Sciences Institute, University of Sao Paulo, Sao Paulo, Brazil.",,,,,"Africa, Western/epidemiology; Animals; Cluster Analysis; *Evolution, Molecular; *Genetic Variation; Humans; Molecular Epidemiology; Molecular Sequence Data; Phylogeny; Sequence Analysis, DNA; Zika Virus/classification/*genetics/isolation & purification; Zika Virus Infection/epidemiology/*virology","Zika virus (ZIKV) is a mosquito-borne flavivirus first isolated in Uganda in 1947. Although entomological and virologic surveillance have reported ZIKV enzootic activity in diverse countries of Africa and Asia, few human cases were reported until 2007, when a Zika fever epidemic took place in Micronesia. In the context of West Africa, the WHO Collaborating Centre for Arboviruses and Hemorrhagic Fever at Institut Pasteur of Dakar (http://www.pasteur.fr/recherche/banques/CRORA/) reports the periodic circulation of ZIKV since 1968. Despite several reports on ZIKV, the genetic relationships among viral strains from West Africa remain poorly understood. To evaluate the viral spread and its molecular epidemiology, we investigated 37 ZIKV isolates collected from 1968 to 2002 in six localities in Senegal and Cote d'Ivoire. In addition, we included strains from six other countries. Our results suggested that these two countries in West Africa experienced at least two independent introductions of ZIKV during the 20(th) century, and that apparently these viral lineages were not restricted by mosquito vector species. Moreover, we present evidence that ZIKV has possibly undergone recombination in nature and that a loss of the N154 glycosylation site in the envelope protein was a possible adaptive response to the Aedes dalzieli vector.",Pubmed,March 31, 2016,Yes,,No,"Zika, indirect evidence or other topic",Scientific (journal) article,Yes,Original research,No,Yes,152,Basic and applied biomedical research,Sequence analysis and phylogenetics
153,"Tappe, Eurosurveillance, 2014",Tappe,"Tappe, D.; Rissland, J.; Gabriel, M.; Emmerich, P.; Gunther, S.; Held, G.; Smola, S.; Schmidt-Chanasit, J.","First case of laboratory-confirmed Zika virus infection imported into Europe, November 2013",Eurosurveillance,19,4,,2014,2010-present,February 11, 2014,24507467,,1415,English,http://www.ncbi.nlm.nih.gov/pubmed/24507467,"Bernhard Nocht Institute for Tropical Medicine, WHO Collaborating Centre for Arbovirus and Haemorrhagic Fever Reference and Research, Hamburg, Germany.",,,,,"Antibodies, Neutralizing/blood/immunology; Antibodies, Viral/analysis; Germany; Humans; Immunoglobulin G/blood; Immunoglobulin M/blood; Male; Real-Time Polymerase Chain Reaction; Thailand; Zika Virus/genetics/immunology/*isolation & purification; Zika Virus Infection/blood/*diagnosis/virology",,Pubmed,March 31, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Original research,No,Yes,153,Clinical/epidemiological research,Case report
154,"Kutsuna, Eurosurveillance, 2014",Kutsuna,"Kutsuna, S., Kato, Y., Takasaki, T., Moi, M., Kotaki, A., Uemura, H., Matono, T., Fujiya, Y., Mawatari, M., Takeshita, N., Hayakawa, K., Kanagawa, S., Ohmagari, N.","Two cases of Zika fever imported from French Polynesia to Japan, December 2013 to January 2014 [corrected]",Eurosurveillance,19,4,,2014,2010-present,February 11, 2014,24507466,,1416,English,http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=20683,"National Center for Global health and Medicine, Disease Control and Prevention Center, Tokyo, Japan.",Japan,Asia,Japan,,"Adult, Diagnosis, Differential, Fever, Humans, Japan, French Polynesia, Reverse Transcriptase Polymerase Chain Reaction, Sequence Analysis, RNA, *Travel, Zika Virus/genetics/*isolation & purification, Zika Virus Infection/*diagnosis/virology","We present two cases of imported Zika fever to Japan, in travellers returning from French Polynesia, where an outbreak due to Zika virus (ZIKV) is ongoing since week 41 of 2013. This report serves to raise awareness among healthcare professionals, that the differential diagnosis of febrile and subfebrile patients with rash should include ZIKV infection, especially in patients returning from areas affected by this virus.",Pubmed,March 31, 2016,Yes,,No,"Zika, not relevant to causality framework",Scientific (journal) article,Yes,Original research,No,Yes,154,Clinical/epidemiological research,Case series
155,"Grard, PLoS Negl Trop Dis, 2014",Grard,"Grard, G., Caron, M., Mombo, I. M., Nkoghe, D., Mboui Ondo, S., Jiolle, D., Fontenille, D., Paupy, C., Leroy, E. M.",Zika virus in Gabon (Central Africa)--2007: a new threat from Aedes albopictus?,PLoS Negl Trop Dis,8,2,e2681,2014,2010-present,February 12, 2014,24516683,10.1371/journal.pntd.0002681,1414,English,,"UMVE, Centre International de Recherches Medicales de Franceville, Franceville, Gabon., UMVE, Centre International de Recherches Medicales de Franceville, Franceville, Gabon ; MIVEGEC, Institut de Recherche pour le Developpement (IRD-224, CNRS-5290, Universites de Montpellier 1 & 2), Montpellier, France., UMVE, Centre International de Recherches Medicales de Franceville, Franceville, Gabon ; Ministere de la Sante Publique, Libreville, Gabon., MIVEGEC, Institut de Recherche pour le Developpement (IRD-224, CNRS-5290, Universites de Montpellier 1 & 2), Montpellier, France ; URES, CIRMF, Franceville, Gabon., MIVEGEC, Institut de Recherche pour le Developpement (IRD-224, CNRS-5290, Universites de Montpellier 1 & 2), Montpellier, France.",Gabon,Africa,Gabon,Mixed,"Aedes/*virology, Animals, Communicable Diseases, Emerging/*virology, Gabon/epidemiology, Humans, Phylogeny, Retrospective Studies, Zika Virus/classification/genetics/*isolation & purification, Zika Virus Infection/epidemiology/*virology","BACKGROUND: Chikungunya and dengue viruses emerged in Gabon in 2007, with large outbreaks primarily affecting the capital Libreville and several northern towns. Both viruses subsequently spread to the south-east of the country, with new outbreaks occurring in 2010. The mosquito species Aedes albopictus, that was known as a secondary vector for both viruses, recently invaded the country and was the primary vector involved in the Gabonese outbreaks. We conducted a retrospective study of human sera and mosquitoes collected in Gabon from 2007 to 2010, in order to identify other circulating arboviruses. METHODOLOGY/PRINCIPAL FINDINGS: Sample collections, including 4312 sera from patients presenting with painful febrile disease, and 4665 mosquitoes belonging to 9 species, split into 247 pools (including 137 pools of Aedes albopictus), were screened with molecular biology methods. Five human sera and two Aedes albopictus pools, all sampled in an urban setting during the 2007 outbreak, were positive for the flavivirus Zika (ZIKV). The ratio of Aedes albopictus pools positive for ZIKV was similar to that positive for dengue virus during the concomitant dengue outbreak suggesting similar mosquito infection rates and, presumably, underlying a human ZIKV outbreak. ZIKV sequences from the envelope and NS3 genes were amplified from a human serum sample. Phylogenetic analysis placed the Gabonese ZIKV at a basal position in the African lineage, pointing to ancestral genetic diversification and spread. CONCLUSIONS/SIGNIFICANCE: We provide the first direct evidence of human ZIKV infections in Gabon, and its first occurrence in the Asian tiger mosquito, Aedes albopictus. These data reveal an unusual natural life cycle for this virus, occurring in an urban environment, and potentially representing a new emerging threat due to this novel association with a highly invasive vector whose geographic range is still expanding across the globe.",Pubmed,March 31, 2016,Yes,,No,"Zika, indirect evidence or other topic",Scientific (journal) article,Yes,Original research,No,Yes,155,Basic and applied biomedical research,Sequence analysis and phylogenetics
156,"Kaddumukasa, J Med Entomol, 2014",Kaddumukasa,"Kaddumukasa, M. A.; Mutebi, J. P.; Lutwama, J. J.; Masembe, C.; Akol, A. M.","Mosquitoes of Zika Forest, Uganda: species composition and relative abundance",J Med Entomol,51,1,104-13,2014,2010-present,March 13, 2014,24605459,,1413,English,http://www.ncbi.nlm.nih.gov/pubmed/24605459,"College of Natural Sciences, Department of Biological Sciences, Makerere University, P.O. Box 7062, Kampala, Uganda.; Centers for Disease Control and Prevention, Division of Vector-Borne Infectious Diseases, Fort Collins, CO 80521, USA.; Department of Arbovirology, Uganda Virus Research Institute (UVRI), P.O. Box 49, Entebbe, Uganda.",,,,,Animals; *Biodiversity; *Culicidae; Humans; Population Density; Uganda,"Mosquito collections were conducted in Zika Forest near Entebbe, Uganda, from July 2009 through June 2010 using CO2-baited light traps, ovitraps, and human-baited catches. In total, 163,790 adult mosquitoes belonging to 12 genera and 58 species were captured. Of these, 22 species (38%) were captured in Zika Forest for the first time. All the new records found in the forest in this study had previously been captured in other regions of Uganda, implying that they are native to the country and do not represent new introductions. More than 20 species previously collected in Zika Forest were not detected in our collections, and this may suggest a change in the mosquito fauna during the past 40 yr or variation in species composition from year to year. Arboviruses of public health importance have previously been isolated from >50% of the 58 mosquito species captured in Zika Forest, which suggests ahigh potential for transmission and maintenance of a wide range of arboviruses in Zika Forest.",Pubmed,March 31, 2016,No,Unrelated to Zika virus,,,Scientific (journal) article,Yes,Original research,No,Yes,156,Environmental and vector research,Ecological/animal cross-sectional
157,"Oehler, Eurosurveillance, 2014",Oehler,"Oehler, E., Watrin, L., Larre, P., Leparc-Goffart, I., Lastere, S., Valour, F., Baudouin, L., Mallet, H., Musso, D., Ghawche, F.","Zika virus infection complicated by Guillain-Barre syndrome--case report, French Polynesia, December 2013",Eurosurveillance,19,9,,2014,2010-present,March 15, 2014,24626205,,1412,English,http://www.eurosurveillance.org/images/dynamic/EE/V19N09/art20720.pdf,"Internal medicine department, French Polynesia Hospital Center, Pirae, Tahiti, French Polynesia.",French Polynesia,Pacific,French Polynesia,Not reported/unknown,"Dengue/*complications, Exanthema/complications, Female, Guillain-Barre Syndrome/*etiology/microbiology/virology, Humans, Middle Aged, Polynesia, Zika Virus/*isolation & purification, Zika Virus Infection/*complications/diagnosis","Zika fever, considered as an emerging disease of arboviral origin, because of its expanding geographic area, is known as a benign infection usually presenting as an influenza-like illness with cutaneous rash. So far, Zika virus infection has never led to hospitalisation. We describe the first case of Guillain-Barre syndrome (GBS) occurring immediately after a Zika virus infection, during the current Zika and type 1 and 3 dengue fever co-epidemics in French Polynesia.",Pubmed,March 31, 2016,Yes,,Yes,,Scientific (journal) article,Yes,Original research,Yes,No,430,Clinical/epidemiological research,Case report
158,"Besnard, Eurosurveillance, 2014",Besnard,"Besnard, M.; Lastere, S.; Teissier, A.; Cao-Lormeau, V.; Musso, D.","Evidence of perinatal transmission of Zika virus, French Polynesia, December 2013 and February 2014",Eurosurveillance,19,13,,2014,2010-present,April 12, 2014,24721538,,1411,English,http://www.ncbi.nlm.nih.gov/pubmed/24721538,"Centre hospitalier de Polynesie francaise, Hopital du Taaone, Tahiti, French Polynesia.",French Polynesia,Pacific,French Polynesia,,"Adult; Breast Feeding; Female; Flavivirus/genetics/*isolation & purification; Humans; Infant, Newborn; *Infectious Disease Transmission, Vertical; Polynesia; Pregnancy; Pregnancy Complications, Infectious/*virology; Pregnancy Outcome; Reverse Transcriptase Polymerase Chain Reaction; Zika Virus/genetics/*isolation & purification; Zika Virus Infection/congenital/diagnosis/*transmission/virology","A Zika virus (ZIKAV) outbreak started in October 2013 in French Polynesia, South Pacific. We describe here the clinical and laboratory features of two mothers and their newborns who had ZIKAV infection as confirmed by ZIKAV RT-PCR performed on serum collected within four days post-delivery in date. The infants' infection most probably occurred by transplacental transmission or during delivery. Attention should be paid to ZIKAV-infected pregnant women and their newborns, as data on the impact on them are limited.",Pubmed,March 31, 2016,Yes,,No,"Zika, not relevant to causality framework",Scientific (journal) article,Yes,Original research,No,Yes,158,Clinical/epidemiological research,Case series
159,"Musso, Eurosurveillance, 2014",Musso,"Musso, D., Nhan, T., Robin, E., Roche, C., Bierlaire, D., Zisou, K., Shan Yan, A., Cao-Lormeau, V. M., Broult, J.","Potential for Zika virus transmission through blood transfusion demonstrated during an outbreak in French Polynesia, November 2013 to February 2014",Eurosurveillance,19,14,,2014,2010-present,April 18, 2014,24739982,,1410,English,,"Unit of Emerging Infectious Diseases, Institut Louis Malarde, Tahiti, French Polynesia.",,,,,"*Blood Donors, Blood Transfusion/*adverse effects, Blood-Borne Pathogens/*isolation & purification, Disease Outbreaks/prevention & control, Female, Humans, Male, Polynesia/epidemiology, RNA, Viral/*blood, Real-Time Polymerase Chain Reaction, Reverse Transcriptase Polymerase Chain Reaction, Zika Virus/genetics/*isolation & purification, Zika Virus Infection/diagnosis/epidemiology/*transmission/virology","Since October 2013, French Polynesia has experienced the largest documented outbreak of Zika virus (ZIKAV) infection. To prevent transmission of ZIKAV by blood transfusion, specific nucleic acid testing of blood donors was implemented. From November 2013 to February 2014: 42 (3%) of 1,505 blood donors, although asymptomatic at the time of blood donation, were found positive for ZIKAV by PCR. Our results serve to alert blood safety authorities about the risk of post-transfusion Zika fever.",Pubmed,March 31, 2016,Yes,,No,"Zika, not relevant to causality framework",Scientific (journal) article,Yes,Original research,No,Yes,159,Clinical/epidemiological research,Cross-sectional study
160,"Kuang, Anim Biotechnol, 2014",Kuang,"Kuang, L.; Xie, X.; Zhang, X.; Lei, M.; Li, C.; Ren, Y.; Zheng, J.; Guo, Z.; Zhang, C.; Yang, C.; Zheng, Y.","Expression profiles of myostatin, myogenin, and Myosin heavy chain in skeletal muscles of two rabbit breeds differing in growth rate",Anim Biotechnol,25,4,223-33,2014,2010-present,May 13, 2014,24813217,10.1080/10495398.2013.865639,1409,English,http://www.ncbi.nlm.nih.gov/pubmed/24813217,"a Sichuan Animal Sciences Academy , Chengdu , China.",,,,,"Animals; Female; Gene Expression; Livestock; Male; Muscle, Skeletal/chemistry/*growth & development/*metabolism; Myogenin/*analysis/genetics/metabolism; Myosin Heavy Chains/*analysis/genetics/metabolism; Myostatin/*analysis/genetics/metabolism; Rabbits/genetics/*growth & development/metabolism; Species Specificity; Myogenin; Myosin heavy chain; Myostatin; Rabbit","The purpose of the present study was to compare mRNA levels of myostatin (MSTN), myogenin (MyoG), and fiber type compositions in terms of myosin heavy chain (MyHC) in skeletal muscles of two rabbit breeds with different body sizes and growth rates. Longissimus dorsi and biceps femoris muscles of 16 Californian rabbits (CW) and 16 Germany great line of ZIKA rabbits (GZ) were collected at the ages of 35d and 84d (slaughter age). The results showed that the live weights of GZ rabbits of 35d and 84d old were approximately 36% and 26% greater than those of CW rabbits, respectively. Quantitative real-time PCR analysis revealed that at the age of 84d GZ rabbits contained significantly lower MSTN mRNA level and higher MyoG mRNA level in both longissimus dorsi and biceps femoris muscles than CW rabbits, and mRNA levels of MSTN and MyoG exhibited opposite changes from the age of 35d to 84d, suggesting that GZ rabbits were subjected to less growth inhibition from MSTN at slaughter age, which occurred most possibly in skeletal muscles. Four types of fiber were identified by real-time PCR in rabbit muscles, with MyHC-1 and MyHC-2D, MyHC-2B were the major types in biceps femoris and longissimus dorsi muscles, respectively. At the age of 84d, GZ rabbits contained greater proportion of MyHC-1 and decreased proportion of MyHC-2D and decreased lactate dehydrogenase activity in biceps femoris than CW rabbits, and the results were exactly opposite in longissimus dorsi, suggesting that GZ rabbits show higher oxidative capacity in biceps femoris muscle than CW rabbits. In conclusion, the trends of mRNA levels of MSTN and fiber types in GZ rabbits' skeletal muscles might be consistent with the putative fast growth characteristic of GZ rabbits compared to CW rabbits.",Pubmed,March 31, 2016,No,Unrelated to Zika virus,,,Scientific (journal) article,Yes,Original research,No,Yes,160,Basic and applied biomedical research,In vitro experiment
161,"Cao-Lormeau, Emerg Infect Dis, 2014",Cao-Lormeau,"Cao-Lormeau, V. M., Roche, C., Teissier, A., Robin, E., Berry, A. L., Mallet, H. P., Sall, A. A., Musso, D.","Zika virus, French polynesia, South pacific, 2013",Emerg Infect Dis,20,6,1085-6,2014,2010-present,May 27, 2014,24856001,10.3201/eid2006.140138,1408,English,,,,,,,"*Disease Outbreaks, Epidemiological Monitoring, Female, Genome, Viral, Humans, Male, *Phylogeny, Polynesia/epidemiology, Viral Proteins/*genetics, Zika Virus/classification/*genetics/isolation & purification, Zika Virus Infection/diagnosis/*epidemiology/virology, French Polynesia, South Pacific, Zika virus, flavivirus, mosquitoes, outbreak, vector-borne infections, viruses",,Pubmed,March 31, 2016,Yes,,No,"Zika, indirect evidence or other topic",Scientific (journal) article,Yes,Original research,Yes,Yes,161,Basic and applied biomedical research,Sequence analysis and phylogenetics
162,"Baronti, Genome Announc, 2014",Baronti,"Baronti, C.; Piorkowski, G.; Charrel, R. N.; Boubis, L.; Leparc-Goffart, I.; de Lamballerie, X.",Complete coding sequence of zika virus from a French polynesia outbreak in 2013,Genome Announc,2,3,,2014,2010-present,June 7, 2014,24903869,10.1128/genomeA.00500-14,1407,English,http://www.ncbi.nlm.nih.gov/pubmed/24903869,"cecile.baronti@univ-amu.fr.; French National Reference Centre for Arboviruses, IRBA, Marseille, France.",,,,,,"Zika virus is an arthropod-borne Flavivirus member of the Spondweni serocomplex, transmitted by Aedes mosquitoes. We report here the complete coding sequence of a Zika virus strain belonging to the Asian lineage, isolated from an infected patient returning from French Polynesia, an epidemic area in 2013/2014.",Pubmed,March 31, 2016,Yes,,No,"Zika, indirect evidence or other topic",Scientific (journal) article,Yes,Original research,Yes,No,161,Basic and applied biomedical research,Sequence analysis and phylogenetics
163,"Musso, Clin Microbiol Infect, 2014",Musso,"Musso, D., Nilles, E. J., Cao-Lormeau, V. M.",Rapid spread of emerging Zika virus in the Pacific area,Clin Microbiol Infect,20,10,O595-6,2014,2010-present,June 10, 2014,24909208,10.1111/1469-0691.12707,1406,English,,"Institut Louis Malarde, Papeete, Tahiti, Polynesie francaise. dmusso@ilm.pf.",,,,,"Aedes/virology, Animals, Communicable Diseases, Emerging/epidemiology/pathology/transmission/virology, Epidemiological Monitoring, Evolution, Molecular, Humans, Pacific Islands/epidemiology, Phylogeny, Zika Virus/*classification/genetics/isolation & purification, Zika Virus Infection/*epidemiology/pathology/*transmission/virology",,Pubmed,March 31, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,163,,
164,"Blazquez, Front Microbiol, 2014",Blazquez,"Blazquez, A. B., Escribano-Romero, E., Merino-Ramos, T., Saiz, J. C., Martin-Acebes, M. A.",Stress responses in flavivirus-infected cells: activation of unfolded protein response and autophagy,Front Microbiol,5,,266,2014,2010-present,June 12, 2014,24917859,10.3389/fmicb.2014.00266,1405,English,,"Departamento de Biotecnologia, Instituto Nacional de Investigacion y Tecnologia Agraria y Alimentaria Madrid, Spain., Departamento de Biotecnologia, Instituto Nacional de Investigacion y Tecnologia Agraria y Alimentaria Madrid, Spain ; Departamento de Virologia y Microbiologia, Centro de Biologia Molecular 'Severo Ochoa', Consejo Superior de Investigaciones Cientificas - Universidad Autonoma de Madrid Madrid, Spain.",Spain,Europe,Spain,Public/Government,"West Nile virus, autophagy, dengue virus, endoplasmic reticulum stress, flavivirus, unfolded protein response, virus replication","The Flavivirus is a genus of RNA viruses that includes multiple long known human, animal, and zoonotic pathogens such as Dengue virus, yellow fever virus, West Nile virus, or Japanese encephalitis virus, as well as other less known viruses that represent potential threats for human and animal health such as Usutu or Zika viruses. Flavivirus replication is based on endoplasmic reticulum-derived structures. Membrane remodeling and accumulation of viral factors induce endoplasmic reticulum stress that results in activation of a cellular signaling response termed unfolded protein response (UPR), which can be modulated by the viruses for their own benefit. Concomitant with the activation of the UPR, an upregulation of the autophagic pathway in cells infected with different flaviviruses has also been described. This review addresses the current knowledge of the relationship between endoplasmic reticulum stress, UPR, and autophagy in flavivirus-infected cells and the growing evidences for an involvement of these cellular pathways in the replication and pathogenesis of these viruses.",Pubmed,March 31, 2016,Yes,,No,"Zika, indirect evidence or other topic",Scientific (journal) article,Yes,Review,No,Yes,164,Basic and applied biomedical research,Basic research review
165,"Pyke, PLoS Curr, 2014",Pyke,"Pyke, A. T.; Daly, M. T.; Cameron, J. N.; Moore, P. R.; Taylor, C. T.; Hewitson, G. R.; Humphreys, J. L.; Gair, R.","Imported zika virus infection from the cook islands into australia, 2014",PLoS Curr,6,,,2014,2010-present,June 20, 2014,24944843,10.1371/currents.outbreaks.4635a54dbffba2156fb2fd76dc49f65e,1404,English,http://www.ncbi.nlm.nih.gov/pubmed/24944843,"Forensic and Scientific Services, Coopers Plains, Queensland, Australia.; Tropical Public Health, Townsville, Australia.; Tropical Public Health, Cairns, Australia.",,,,,arbovirus; infectious disease,"A female resident of Townsville, Queensland, Australia has been diagnosed with Zika virus infection following a recent trip to the Cook Islands. An initial serum sample collected in March, 2014 was positive by two separate Zika virus TaqMan real-time RT-PCRs and a pan-Flavivirus RT-PCR. Nucleotide sequencing and phylogenetics of the complete Cook Islands Zika virus envelope gene revealed 99.1% homology with a previous Cambodia 2010 sequence within the Asian lineage. In addition, IgG and IgM antibody seroconversions were detected between paired acute and convalescent phase sera using recombinant Zika virus serology assays. This is the first known imported case of Zika virus infection into northern Queensland where the potential mosquito vector <i>Aedes aegypti</i> is present and only the second such reported case diagnosed within Australia.",Pubmed,March 31, 2016,Yes,,No,"Zika, indirect evidence or other topic",Scientific (journal) article,Yes,Original research,No,Yes,165,Basic and applied biomedical research,Sequence analysis and phylogenetics
166,"[No authors listed], Emerg Infect Dis, 2014",[No authors listed],[No authors listed],Zika virus,Emerg Infect Dis,20,6,1090,2014,2010-present,July 2, 2014,24983096,10.3201/eid2006.ET2006,2009,English,http://www.ncbi.nlm.nih.gov/pubmed/24983096,,,,,,Animals; *Disease Outbreaks; Humans; Macaca mulatta; Micronesia/epidemiology; Polynesia/epidemiology; Primate Diseases/epidemiology/*virology; Terminology as Topic; Uganda; Zika Virus/*genetics/isolation & purification; Zika Virus Infection/*epidemiology/virology,,Pubmed,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Other,,,No,Yes,166,,
167,"Ioos, Med Mal Infect, 2014",Ioos,"Ioos, S.; Mallet, H. P.; Leparc Goffart, I.; Gauthier, V.; Cardoso, T.; Herida, M.",Current Zika virus epidemiology and recent epidemics,Med Mal Infect,44,7,302-7,2014,2010-present,July 9, 2014,25001879,10.1016/j.medmal.2014.04.008,1402,English,http://www.ncbi.nlm.nih.gov/pubmed/25001879,"Institut de veille sanitaire, departement de coordination des alertes et des regions, 12, rue du Val d'Osne, 94415 St-Maurice, France. Electronic address: s.ioos@invs.sante.fr.; Direction de la sante, bureau de veille sanitaire, Papeete, French Polynesia.; Centre national de reference Arbovirus, IRBA, Marseille, France.; Institut de veille sanitaire, departement de coordination des alertes et des regions, 12, rue du Val d'Osne, 94415 St-Maurice, France.",France,Europe,France,Not reported/unknown,"Adolescent; Adult; Aedes/*virology; Africa/epidemiology; Aged; Animals; Asia/epidemiology; Child; Child, Preschool; Communicable Diseases, Emerging/*epidemiology/prevention & control/virology; *Disease Outbreaks; Haplorhini; Humans; Infant; Insect Bites and Stings/virology; Insect Vectors/*virology; Male; Micronesia/epidemiology; Middle Aged; Monkey Diseases/epidemiology/virology; Mosquito Control; Polynesia/epidemiology; Young Adult; Zika Virus/*isolation & purification/pathogenicity; Zika Virus Infection/*epidemiology/prevention & control/transmission/virology; Aedes; Arbovirus; French Polynesia; Polynesie francaise; Virus Zika; Yap; Zika virus","The Zika virus (ZIKV) is a mosquito-borne flavivirus (Aedes), similar to other arboviruses, first identified in Uganda in 1947. Few human cases were reported until 2007, when a Zika outbreak occurred in Yap, Micronesia, even though ZIKV activity had been reported in Africa and in Asia through virological surveillance and entomological studies. French Polynesia has recorded a large outbreak since October 2013. A great number of cases and some with neurological and autoimmune complications have been reported in a context of concurrent circulation of dengue viruses. The clinical presentation is a 'dengue-like syndrome'. Until the epidemic in French Polynesia, no severe ZIKV disease had been described so far. The diagnosis is confirmed by viral genome detection by genomic amplification (RT- PCR) and viral isolation. These two large outbreaks occurred in a previously unaffected area in less than a decade. They should raise awareness as to the potential for ZIKV to spread especially since this emergent disease is not well known and that some questions remain on potential reservoirs and transmission modes as well as on clinical presentations and complications. ZIKV has the potential to spread to new areas where the Aedes mosquito vector is present and could be a risk for Southern Europe. Strategies for the prevention and control of ZIKV disease should include the use of insect repellent and mosquito vector eradication.",Pubmed,March 31, 2016,Yes,,Yes,,Scientific (journal) article,Yes,Original research,Yes,Yes,167,Clinical/epidemiological research,Ecological study/outbreak report
168,"Waehre, Emerg Infect Dis, 2014",Waehre,"Waehre, T., Maagard, A., Tappe, D., Cadar, D., Schmidt-Chanasit, J.","Zika virus infection after travel to Tahiti, December 2013",Emerg Infect Dis,20,8,1412-4,2014,2010-present,July 26, 2014,25062427,10.3201/eid2008.140302,1401,English,,,,,,,"Adult, Female, Flavivirus/classification/*genetics, Flavivirus Infections/*diagnosis/*virology, Genes, Viral, Humans, Phylogeny, Polynesia, *Travel, French Polynesia, Tahiti, Zika virus, febrile syndrome, mosquito, travel, viruses",,Pubmed,March 31, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Original research,No,Yes,168,Clinical/epidemiological research,Case report
169,"Healy, PLoS One, 2014",Healy,"Healy, K.; Hamilton, G.; Crepeau, T.; Healy, S.; Unlu, I.; Farajollahi, A.; Fonseca, D. M.",Integrating the public in mosquito management: active education by community peers can lead to significant reduction in peridomestic container mosquito habitats,PLoS One,9,9,e108504,2014,2010-present,September 26, 2014,25255027,10.1371/journal.pone.0108504,1400,English,http://www.ncbi.nlm.nih.gov/pubmed/25255027,"Center for Vector Biology, Department of Entomology, Rutgers University, New Brunswick, New Jersey, United States of America.; Monmouth County Mosquito Extermination Commission, Eatontown, New Jersey, United States of America.; Mercer County Mosquito Commission, West Trenton, New Jersey, United States of America.",,,,,Animals; Arbovirus Infections/transmission; Community Health Services; *Culicidae; Health Education; Humans; *Insect Vectors; *Mosquito Control; New Jersey; *Public Health Practice; Seasons,"Mosquito species that utilize peridomestic containers for immature development are commonly aggressive human biters, and because they often reach high abundance, create significant nuisance. One of these species, the Asian tiger mosquito Aedes albopictus, is an important vector of emerging infectious diseases, such as dengue, chikungunya, and Zika fevers. Integrated mosquito management (IMM) of Ae. albopictus is particularly difficult because it requires access to private yards in urban and suburban residences. It has become apparent that in the event of a public health concern due to this species, homeowners will have to be active participants in the control process by reducing mosquito habitats in their properties, an activity known as source reduction. However, limited attempts at quantifying the effect of source reduction by homeowners have had mixed results. Of note, many mosquito control programs in the US have some form of education outreach, however the primary approach is often passive focusing on the distribution of education materials as flyers. In 2010, we evaluated the use of active community peer education in a source reduction program, using AmeriCorps volunteers. The volunteers were mobilized over a 4-week period, in two areas with approximately 1,000 residences each in urban Mercer and suburban Monmouth counties in New Jersey, USA. The volunteers were first provided training on peridomestic mosquitoes and on basic approaches to reducing the number of container habitats for mosquito larvae in backyards. Within the two treatment areas the volunteers successfully engaged 758 separate homes. Repeated measures analysis of variance showed a significant reduction in container habitats in the sites where the volunteers actively engaged the community compared to untreated control areas in both counties. Our results suggest that active education using community peer educators can be an effective means of source reduction, and a critical tool in the arsenal against peridomestic mosquitoes.",Pubmed,March 31, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Original research,No,Yes,169,Environmental and vector research,Other ecological
170,"Fonseca, Am J Trop Med Hyg, 2014",Fonseca,"Fonseca, K.; Meatherall, B.; Zarra, D.; Drebot, M.; MacDonald, J.; Pabbaraju, K.; Wong, S.; Webster, P.; Lindsay, R.; Tellier, R.",First case of Zika virus infection in a returning Canadian traveler,Am J Trop Med Hyg,91,5,1035-8,2014,2010-present,October 9, 2014,25294619,10.4269/ajtmh.14-0151,1399,English,http://www.ncbi.nlm.nih.gov/pubmed/25294619,"Provincial Laboratory for Public Health, Calgary, Alberta, Canada; Alberta Health Services, Calgary, Alberta, Canada; National Microbiology Laboratory; Public Health Agency of Canada, Winnipeg, Manitoba, Canada; University of Calgary, Calgary, Alberta, Canada; University of Manitoba, Winnipeg, Manitoba, Canada kevin.fonseca@albertahealthservices.ca.; Provincial Laboratory for Public Health, Calgary, Alberta, Canada; Alberta Health Services, Calgary, Alberta, Canada; National Microbiology Laboratory; Public Health Agency of Canada, Winnipeg, Manitoba, Canada; University of Calgary, Calgary, Alberta, Canada; University of Manitoba, Winnipeg, Manitoba, Canada.",,,,,"Antibodies, Viral/blood; Canada; Dengue/blood/diagnosis/immunology; Diagnostic Errors; Female; Fever; Humans; Immunoglobulin M/blood; Polymerase Chain Reaction; RNA, Viral/isolation & purification; Thailand; Travel; Zika Virus/*isolation & purification; Zika Virus Infection/blood/*diagnosis/*epidemiology/immunology","A woman who recently traveled to Thailand came to a local emergency department with a fever and papular rash. She was tested for measles, malaria, and dengue. Positive finding for IgM antibody against dengue and a failure to seroconvert for IgG against dengue for multiple blood samples suggested an alternate flavivirus etiology. Amplification of a conserved region of the non-structural protein 5 gene of the genus Flavivirus yielded a polymerase chain reaction product with a matching sequence of 99% identity with Zika virus. A urine sample and a nasopharygeal swab specimen obtained for the measles investigation were also positive for this virus by reverse transcription polymerase chain reaction. Subsequently, the urine sample yielded a Zika virus isolate in cell culture. This case report describes a number of novel clinical and laboratory findings, the first documentation of this virus in Canada, and the second documentation from this region in Thailand.",Pubmed,March 31, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Original research,No,Yes,170,Clinical/epidemiological research,Case report
171,"Ledermann, PLoS Negl Trop Dis, 2014",Ledermann,"Ledermann, J. P.; Guillaumot, L.; Yug, L.; Saweyog, S. C.; Tided, M.; Machieng, P.; Pretrick, M.; Marfel, M.; Griggs, A.; Bel, M.; Duffy, M. R.; Hancock, W. T.; Ho-Chen, T.; Powers, A. M.",Aedes hensilli as a potential vector of Chikungunya and Zika viruses,PLoS Negl Trop Dis,8,10,e3188,2014,2010-present,October 10, 2014,25299181,10.1371/journal.pntd.0003188,1398,English,http://www.ncbi.nlm.nih.gov/pubmed/25299181,"Division of Vector-Borne Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado, United States of America.; URE-Entomologie Medicale, Institut Pasteur de Nouvelle-Caledonie, Noumea, New Caledonia.; Environmental Health Services, Division of Public Health, Department of Health Services, Pohnpei, Federated States of Micronesia.; National Food Safety Program, Department of Health and Social Affairs, Pohnpei, Federated States of Micronesia.; Department of Health, Education and Social Affairs, Pohnpei, Federated States of Micronesia.; Wa'ab Community Health Center, Yap, Federated States of Micronesia.; Epidemic Intelligence Service Field Assignments Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America.",,,,,Aedes/*virology; Animals; Chikungunya Fever/epidemiology/*transmission; Chikungunya virus/*physiology; Dengue/epidemiology/transmission; Disease Outbreaks; Humans; Insect Vectors/*virology; Micronesia/epidemiology; Species Specificity; Zika Virus/*physiology; Zika Virus Infection/epidemiology/*transmission,"An epidemic of Zika virus (ZIKV) illness that occurred in July 2007 on Yap Island in the Federated States of Micronesia prompted entomological studies to identify both the primary vector(s) involved in transmission and the ecological parameters contributing to the outbreak. Larval and pupal surveys were performed to identify the major containers serving as oviposition habitat for the likely vector(s). Adult mosquitoes were also collected by backpack aspiration, light trap, and gravid traps at select sites around the capital city. The predominant species found on the island was Aedes (Stegomyia) hensilli. No virus isolates were obtained from the adult field material collected, nor did any of the immature mosquitoes that were allowed to emerge to adulthood contain viable virus or nucleic acid. Therefore, laboratory studies of the probable vector, Ae. hensilli, were undertaken to determine the likelihood of this species serving as a vector for Zika virus and other arboviruses. Infection rates of up to 86%, 62%, and 20% and dissemination rates of 23%, 80%, and 17% for Zika, chikungunya, and dengue-2 viruses respectively, were found supporting the possibility that this species served as a vector during the Zika outbreak and that it could play a role in transmitting other medically important arboviruses.",Pubmed,March 31, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Original research,No,Yes,171,Environmental and vector research,Ecological/animal cross-sectional
172,"Diallo, PLoS One, 2014",Diallo,"Diallo, D., Sall, A. A., Diagne, C. T., Faye, O., Faye, O., Ba, Y., Hanley, K. A., Buenemann, M., Weaver, S. C., Diallo, M.","Zika virus emergence in mosquitoes in southeastern Senegal, 2011",PLoS One,9,10,e109442,2014,2010-present,October 14, 2014,25310102,10.1371/journal.pone.0109442,1397,English,,"Unite d'Entomologie Medicale, Institut Pasteur de Dakar, Dakar, Senegal., Unite des Arbovirus et Virus des Fievres Hemorragiques, Institut Pasteur de Dakar, Dakar, Senegal., Department of Biology, New Mexico State University, Las Cruces, New Mexico, United States of America., Department of Geography, New Mexico State University, Las Cruces, New Mexico, United States of America., Institute for Human Infections and Immunity, Center for Tropical Diseases, and Department of Pathology, University of Texas Medical Branch, Galveston, Texas, United States of America.",,,,,"Aedes/virology, Animals, Culicidae/*virology, Disease Outbreaks, Humans, Insect Vectors/*virology, Male, Senegal/epidemiology, Zika Virus/*isolation & purification, *Zika Virus Infection/epidemiology/virology","BACKGROUND: Zika virus (ZIKV; genus Flavivirus, family Flaviviridae) is maintained in a zoonotic cycle between arboreal Aedes spp. mosquitoes and nonhuman primates in African and Asian forests. Spillover into humans has been documented in both regions and the virus is currently responsible for a large outbreak in French Polynesia. ZIKV amplifications are frequent in southeastern Senegal but little is known about their seasonal and spatial dynamics. The aim of this paper is to describe the spatio-temporal patterns of the 2011 ZIKV amplification in southeastern Senegal. METHODOLOGY/FINDINGS: Mosquitoes were collected monthly from April to December 2011 except during July. Each evening from 18:00 to 21:00 hrs landing collections were performed by teams of 3 persons working simultaneously in forest (canopy and ground), savannah, agriculture, village (indoor and outdoor) and barren land cover sites. Mosquitoes were tested for virus infection by virus isolation and RT-PCR. ZIKV was detected in 31 of the 1,700 mosquito pools (11,247 mosquitoes) tested: Ae. furcifer (5), Ae. luteocephalus (5), Ae. africanus (5), Ae. vittatus (3), Ae. taylori, Ae. dalzieli, Ae. hirsutus and Ae. metallicus (2 each) and Ae. aegypti, Ae. unilinaetus, Ma. uniformis, Cx. perfuscus and An. coustani (1 pool each) collected in June (3), September (10), October (11), November (6) and December (1). ZIKV was detected from mosquitoes collected in all land cover classes except indoor locations within villages. The virus was detected in only one of the ten villages investigated. CONCLUSIONS/SIGNIFICANCE: This ZIKV amplification was widespread in the Kedougou area, involved several mosquito species as probable vectors, and encompassed all investigated land cover classes except indoor locations within villages. Aedes furcifer males and Aedes vittatus were found infected within a village, thus these species are probably involved in the transmission of Zika virus to humans in this environment.",Pubmed,March 31, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Original research,No,Yes,172,Environmental and vector research,Ecological/animal cross-sectional
173,"Hancock, Emerg Infect Dis, 2014",Hancock,"Hancock, W. T., Marfel, M., Bel, M.","Zika virus, French Polynesia, South Pacific, 2013",Emerg Infect Dis,20,11,1960,2014,2010-present,October 24, 2014,25341051,10.3201/eid2011.141380,1396,English,,,,,,,"*Disease Outbreaks, Female, Humans, Male, *Phylogeny, Viral Proteins/*genetics, Zika Virus/*genetics, Zika Virus Infection/*epidemiology",,Pubmed,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,Yes,No,161,,
174,"Roth, Eurosurveillance, 2014",Roth,"Roth, A.; Mercier, A.; Lepers, C.; Hoy, D.; Duituturaga, S.; Benyon, E.; Guillaumot, L.; Souares, Y.","Concurrent outbreaks of dengue, chikungunya and Zika virus infections - an unprecedented epidemic wave of mosquito-borne viruses in the Pacific 2012-2014",Eurosurveillance,19,41,,2014,2010-present,October 28, 2014,25345518,,1395,English,http://www.ncbi.nlm.nih.gov/pubmed/25345518,"Secretariat of the Pacific Community, New Caledonia.",,,,,Aedes/*virology; Animals; Chikungunya Fever/*epidemiology; *Chikungunya virus/isolation & purification; Dengue/*epidemiology; *Dengue Virus/isolation & purification; *Disease Outbreaks; Humans; Incidence; Pacific Islands/epidemiology; Population Surveillance; Public Health Surveillance; *Zika Virus/isolation & purification; Zika Virus Infection/*epidemiology/virology,"Since January 2012, the Pacific Region has experienced 28 new documented outbreaks and circulation of dengue, chikungunya and Zika virus. These mosquito-borne disease epidemics seem to become more frequent and diverse, and it is likely that this is only the early stages of a wave that will continue for several years. Improved surveillance and response measures are needed to mitigate the already heavy burden on island health systems and limit further spread to other parts of the world. ",Pubmed,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,174,,
175,"Berthet, Vector Borne Zoonotic Dis, 2014",Berthet,"Berthet, N.; Nakoune, E.; Kamgang, B.; Selekon, B.; Descorps-Declere, S.; Gessain, A.; Manuguerra, J. C.; Kazanji, M.",Molecular characterization of three Zika flaviviruses obtained from sylvatic mosquitoes in the Central African Republic,Vector Borne Zoonotic Dis,14,12,862-5,2014,2010-present,December 17, 2014,25514122,10.1089/vbz.2014.1607,1393,English,http://www.ncbi.nlm.nih.gov/pubmed/25514122,"1 Institut Pasteur de Bangui , Virology Department, Bangui, Central African Republic .",Central African Republic,Africa,Central African Republic,Private,Aedes/*virology; Amino Acid Sequence; Animals; Base Sequence; Central African Republic/epidemiology; Insect Vectors/*virology; Molecular Sequence Data; Phylogeny; *Zika Virus/classification/genetics; Zika Virus Infection/epidemiology/virology; Aedes africanus; Aedes opok; Central Africa; Genomic characterization; Zika virus,"Zika virus (ZIKV) is an emerging pathogen belonging to the Spondweni serocomplex within the genus Flavivirus. It has been isolated from several mosquito species. Two lineages of ZIKV have been defined by polyprotein homology. Using high-throughput sequencing, we obtained and characterized three complete genomes of ZIKV isolated between 1976 and 1980 in the Central African Republic. The three viruses were isolated from two species of mosquito, Aedes africanus and Ae. opok. Two sequences from Ae. africanus had 99.9% nucleotide sequence identity and 100% amino acid identity, whereas the complete genome obtained from Ae. opok had 98.3% nucleotide identity and 99.4% amino acid identity with the other two genomes. Phylogenetic analysis based on the amino acid sequence of the polyprotein showed that the three ZIKV strains clustered together but diverged from all other ZIKV strains. Our molecular data suggest that a different subtype of West African ZIKV strains circulated in Aedes species in Central Africa.",Pubmed,March 31, 2016,Yes,,No,"Zika, indirect evidence or other topic",Scientific (journal) article,Yes,Original research,No,Yes,175,Basic and applied biomedical research,Sequence analysis and phylogenetics
176,"Barbaud, Ann Dermatol Venereol, 2014",Barbaud,"Barbaud, A.",[What's new in clinical dermatology?],Ann Dermatol Venereol,141 Suppl 4,,S597-609,2014,2010-present,December 30, 2014,25539751,10.1016/s0151-9638(14)70163-2,1391,French,,"Departement de dermatologie et allergologie, batiment des specialites medicales, hopitaux de Brabois, centre hospitalo-universitaire de Nancy, 54500 Vandoeuvre-les-Nancy, France. Electronic address: a.barbaud@chu-nancy.fr.",,,,,"Dermatology/*trends, Humans, Skin Diseases/classification/diagnosis/etiology/therapy, Chronic urticaria, Cutaneous adverse drug reactions, Demodicosis, Demodecie, Genetique, Hidradenitis suppurativa, Hidradenite suppurative, Methylisothiazolinone, Parvovirus, Pemphigoid, Pemphigoide, Psoriasis, Toxidermies, Urticaire chronique, Urticaria","Dermatoses have been better characterized as hypochromic vitiligo in subjects with dark skin or the acquired racquet nails associated with hyperparathyroidism. The innate immunity has a central role in the new classification of auto inflammatory diseases, neutrophilic dermatoses, neutrophilic urticaria or pseudo-neutrophilic urticaria. Comorbidities have been studied e.g. cardiovascular co morbidities for psoriasis, IBD associated with hidradenitis suppurativa or neurological disorders associated with pemphigoid. Bullous pemphigoid could be renamed as cutaneous pemphigoid, it can be induced by drugs especially gliptins. Genetic predispositions are analyzed in auto inflammatory diseases, psoriasis (HLA), drug eruptions (HLA or cytokines). Telaprevir often induces rashes, which can be severe but other treatments against hepatitis C as interferon can also induce debilitating rashes, some eligible for drug tolerance induction. European guidelines for the definition, classification, diagnosis of chronic spontaneous urticaria have been published. Severe cutaneous adverse drug reactions may be associated with severe systemic symptoms such as organ involvement in AGEP or the occurrence of a shock in DRESS. Allover Europe, there is now an epidemic of contact allergies to methylisothiazolinone (MIT), contained in cosmetics, wet wipes but also in paints. MIT should be tested at 2.000 ppm in water, included in the standard series for patch tests. Its role has to be evoked in any case localized on the face or hand, airborne or generalized eczema. Among infectious diseases, skin manifestations due to Parvovirus have been specified, a febrile rash can be related to dengue infection or to Zika virus.",Pubmed,March 31, 2016,No,Unrelated to Zika virus,,,Scientific (journal) article,Yes,Review,No,Yes,176,Clinical/epidemiological research,Epidemiological/clinical review
177,"Kading, Am J Trop Med Hyg, 2014",Kading,"Kading, R. C., Kityo, R., Mossel, E., Towner, J., Amman, B., Sealy, T., Nakayiki, T., Kerbis, J., Nalikka, B., Borland, E., Ledermann, J., Panella, N., Gilbert, A., Nyakarahuka, L., Crabtree, M., Waswa, S., Nichol, S., Lutwama, J., Miller, B.",Arbovirus surveillance in bats in Uganda,Am J Trop Med Hyg,1),,260,2014,2010-present,,71692085,,1650,English,"http://www.ajtmh.org/content/91/5_Suppl_1/228.full.pdf+html, http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emed12&AN=71692085","(Kading, Mossel, Borland, Ledermann, Panella, Crabtree, Miller) Centers for Disease Control and Prevention, Fort Collins, CO, United States (Kityo, Nalikka, Waswa) Makerere University, Kampala, Uganda (Towner, Amman, Sealy, Gilbert, Nichol) Centers for Disease Control and Prevention, Atlanta, GA, United States (Nakayiki, Nyakarahuka, Lutwama) Uganda Virus Research Institute, Entebbe, Uganda (Kerbis) Field Museum, Chicago, IL, United States, R.C. Kading, Centers for Disease Control and Prevention, Fort Collins, CO, United States",,,,,"Uganda, society, tropical medicine, hygiene, Arbovirus, virus, date (fruit), Flavivirus, tissues, virus isolation, Vero cell line, blood, forest, chikungunya, serodiagnosis, O nyong nyong virus, yellow fever, exposure, Rift Valley fever, species, fruit, serum, Dengue virus 2, neutralizing antibody, tissue culture medium, antibody","Arboviruses including Rift Valley fever (RVFV), Yellow fever (YFV), West Nile (WNV), Chikungunya (CHIKV) and Zika (ZIKV) viruses have been isolated or detected serologically from various East African bats, however the role of bats in arbovirus transmission cycles is poorly understood. The aim of this study was to investigate the exposure history of Uganda bats to arboviruses as well as attempt virus isolation from bat tissues. Blood, tissues, or both were obtained from 1067 bats from Uganda between 2009 and 2013. Liver/spleen samples were mechanically homogenized in tissue culture media and virus isolation was performed on Vero cells. Virus isolates were identified by either RT-PCR using virus group-specific primers, or next generation sequencing. Serum samples were tested for specific neutralizing antibodies against WNV, YFV, Dengue 2 (DENV2) virus, CHIKV, O'nyong-nyong virus (ONNV), Babanki virus (BABV), ZIKV and RVFV by plaque reduction neutralization test. Rousettus aegyptiacus from Maramagambo forest in western Uganda had specific neutralizing antibodies against CHIKV (2/303), ONNV (32/303), YFV (3/303) and WNV (1/303). R. aegyptiacus from Mt. Elgon in eastern Uganda also contained neutralizing antibodies against YFV (1/45). Epomophorus labiatus from the Entebbe/Kampala area demonstrated specific neutralizing antibodies against BABV (3/52), DENV2 (1/52), and WNV (2/52). DENV2 antibodies were also present in Chaerephon pumila (3/123) and Mops condylura (1/36) captured around Entebbe, and Nycteris spp. (2/10) from Mt. Elgon. One C. pumila also had a high neutralizing titer against ONNV. Virus isolates to date include Entebbe bat virus (Flaviviridae: Flavivirus) from C. pumila in Entebbe. Testing is still in progress and complete results will be presented. Serological and virological evidence suggest that multiple species of fruit and insectivorous bats from Uganda are exposed to and are potential amplification hosts for arboviruses.",Embase,March 31, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Original research,No,Yes,177,Environmental and vector research,Ecological/animal cross-sectional
178,"Schaffner, Lancet Infect Dis, 2014",Schaffner,"Schaffner, F.; Mathis, A.","Dengue and dengue vectors in the WHO European region: past, present, and scenarios for the future",Lancet Infect Dis,14,12,1271-80,2014,2010-present,,25172160,10.1016/S1473-3099(14)70834-5,1899,,http://www.ncbi.nlm.nih.gov/pubmed/25172160,"Institute of Parasitology, Swiss National Centre for Vector Entomology, University of Zurich, Zurich, Switzerland.; Institute of Parasitology, Swiss National Centre for Vector Entomology, University of Zurich, Zurich, Switzerland. Electronic address: alexander.mathis@uzh.ch.",,,,,Aedes/*growth & development; Animals; Dengue/*epidemiology/prevention & control; Epidemiological Monitoring; Europe/epidemiology; Humans; *Insect Vectors; Mosquito Control/methods,"After 55 years of absence, dengue has re-emerged in the WHO European region both as locally transmitted sporadic cases and as an outbreak in Madeira, driven by the introduction of people infected with the virus and the invasion of the vector mosquito species Aedes aegypti and Aedes albopictus. Models predict a further spread of A albopictus, particularly under climate change conditions. Dengue transmission models suggest a low risk in Europe, but these models too rarely include transmission by A albopictus (the main established vector). Further information gaps exist with regard to the Caucasus and central Asian countries of the WHO European region. Many European countries have implemented surveillance and control measures for invasive mosquitoes, but only a few include surveillance for dengue. As long as no dengue-specific prophylaxis or therapeutics are available, integrated vector management is the most sustainable control option. The rapid elimination of newly introduced A aegypti populations should be targeted in the European region, particularly in southern Europe and the Caucasus, where the species was present for decades until the 1950s.",Lancet,March 31, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Review,No,Yes,178,Environmental and vector research,Ecological/Vector review
179,"Cao-Lormeau, Am J Trop Med Hyg, 2014",Cao-Lormeau,"Cao-Lormeau, V. M., Roche, C., Teissier, A., Nilles, E. J., Musso, D.","Epidemiological and molecular features of dengue, Zika and Chikungunya concurrent outbreaks in the pacific, 2014",Am J Trop Med Hyg,1,,588,2014,2010-present,,71693147,,1649,English,,"(Cao-Lormeau, Roche, Teissier, Musso) Institut Louis Malarde, Papeete - Tahiti, French Polynesia (Nilles) World Health Organization, Division of Pacific Technical Support, Suva, Fiji, V.-M. Cao-Lormeau, Institut Louis Malarde, Papeete - Tahiti, French Polynesia",French Polynesia,Pacific,French Polynesia,,"chikungunya, society, tropical medicine, hygiene, dengue, French Polynesia, New Caledonia, virus, Dengue virus, Pacific islands, epidemiology, public health, mosquito, laboratory, serum, Fiji, Chikungunya alphavirus, Papua New Guinea, diseases, genotype, Cook Islands, Tonga, island (geological), Arbovirus, filter, saliva, cotton, rna, virus RNA","During more than a century dengue has been the only mosquito-borne virus considered as major public health concern for Pacific nations. However, during the past 5 years the epidemiology of arboviruses in the Pacific region has shown terrific changes. The situation gradually switched from the predominant circulation of a single dengue virus (DENV) to active transmission of multiple DENV serotypes and genotypes as observed in French Polynesia from 2013 and in New Caledonia and Fiji since the beginning of 2014. In the mean time, Chikungunya virus (CHIKV) appeared for the first time in New Caledonia with autochtonous cases sporadically reported from 2011 up to 2013, and large outbreaks occurring in Papua New Guinea in 2012, Yap Island in 2013 and in Tonga in 2014. Another unexpected event was the emergence of Zika virus (ZIKV) in French Polynesia at the end of 2013. ZIKV caused in French Polynesia the largest outbreak ever documented, and in a context of active circulation of DENV serotypes 1 and 3. At the beginning of 2014, ZIKV outbreaks also emerged in New Caledonia and Cook Islands. As of April 2014, outbreaks of 'dengue-like illnesses' were under investigation in several other Pacific islands suggesting that the situation was evolving from bad to worse. We will describe here the early laboratory investigations that contributed to the identification of the aetiological agents of the outbreaks that recently occurred in the Pacific, notably based on the use of filter paper-spotted serum and saliva collected on cotton swab as a source of viral RNA. Based on phylogenetic data we will discuss how these viruses were introduced from continental regions into the Pacific and how they spread from one Pacific island country to another. We will also discuss the particular features of these outbreaks, notably in the occurrence of unusual clinical manifestations, like observed in French Polynesia during the ZIKV outbreak.",Embase,March 31, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Yes,Original research,No,Yes,179,Basic and applied biomedical research,Sequence analysis and phylogenetics
180,"[No authors listed], Eurosurveillance, 2014",[No authors listed],[No authors listed],"Erratum to Two cases of Zika fever imported from French Polynesia to Japan, December 2013 to January 2014 (Eurosurveillance, (2014), 19, 4)",Eurosurveillance,19,5,,2014,2010-present,,2014100736,,1643,English,"http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=20694, http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emed12&AN=2014100736",,,,,,"erratum, error",,Embase,March 31, 2016,No,Duplicate of existing record,,,,,,,,,,
181,"Hearn, Am J Trop Med Hyg, 2014",Hearn,"Hearn, P. T., Atkinson, B., Hewson, R., Brooks, T.",Identification of the first case of imported Zika Fever to the UK: A novel sample type for diagnostic purposes and support for a potential non-vectorborne route of transmission,Am J Trop Med Hyg,1),,62-63,2014,2010-present,,71691435,,1651,English,"http://www.ajtmh.org/content/91/5_Suppl_1/1.1.full.pdf+html, http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emed12&AN=71691435","(Hearn, Brooks) Rare and Imported Pathogen Laboratory, Porton Down, United Kingdom (Atkinson, Hewson) Public Health England, Porton Down, United Kingdom, P.T. Hearn, Rare and Imported Pathogen Laboratory, Porton Down, United Kingdom",,,,,"United Kingdom, diagnosis, society, tropical medicine, hygiene, fever, human, patient, rash, sperm, dengue, headache, Flavivirus, travel, virus, Cook Islands, sexual transmission, scientist, maculopapular rash, fatigue, urine, exposure, diseases, infection, mosquito, French Polynesia, United States, Africa, Uganda, forest, serology, arthralgia, laboratory, pathogenesis, cross reaction, blood, myalgia, serum, Senegal, Aedes, immunoglobulin G, immunoglobulin M","Zika virus (ZIKV) is a flavivirus related to Dengue, is transmitted by the Aedes mosquito and normally causes a self-limiting illness characterised by fever, rash, headache, conjunctival suffusion, myalgia and joint pains. It was discovered in 1947 at Zika Forest, near to Entebbe, Uganda. More recently it has been found outside Africa in outbreaks such as those of French Polynesia and the Cook Islands. We report the first case of imported Zika Fever to the UK, highlight novel samples for testing and a theoretical mode of non-vector-borne transmission. A couple travelled to the Cook Islands during what was thought to be a Dengue outbreak in February 2014. Within 6 days of exposure, both 'Patient 1' and his wife, 'Patient 2', had developed fatigue, followed 48 hours later by fever, headache, aching joints and a widespread maculopapular rash. Both reported symptoms resolving by day 5 of rash onset. In 2011, Foy et al described likely sexual transmission of ZIKV. A scientist from Colorado, travelling back from Senegal whilst incubating the virus, reportedly passed it to his wife, in whom clinical and serological evidence supported the diagnosis. On day 1 of rash onset, Patient 1 had serum sent to the Rare and Imported Pathogens Laboratory at Porton Down and a panel of serological tests based on stated travel was performed. Dengue testing revealed positive IgM, but negative IgG and PCR. This pattern has been reported previously due to cross-reactivity between the flaviviruses. The sample was then tested by PCR for ZIKV and found to be positive. Further samples were taken on day 28 after rash onset. Blood and urine from both patients were tested in parallel, along with a semen sample from Patient 1. The semen was the only sample found to be positive for ZIKV by PCR. The reasons for persistence in the semen are not yet clear, but this case is significant not only as the first case of Zika Fever imported to the UK, but also as support for the possibility of sexual transmission, though not in this case, and highlights an additional sample type for the confirmation of infection in the future.",Embase,March 31, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Original research,No,Yes,181,Clinical/epidemiological research,Case series
182,"Freire, PLoS Negl Trop Dis, 2014",Freire,"Freire, C. C. M., Iamarino, A., Faye, O., de Oliveira, J. V. C., Diallo, M., Zanotto, P. M. A., Sall, A. A.",Molecular Evolution of Zika Virus during Its Emergence in the 20<sup>th</sup> Century,PLoS Negl Trop Dis,8,1,36,2014,2010-present,,2014108178,http://dx.doi.org/10.1371/journal.pntd.0002636,1644,English,"http://www.plosntds.org/article/fetchObject.action?uri=info%3Adoi%2F10.1371%2Fjournal.pntd.0002636&representation=PDF, http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emed12&AN=2014108178","(Faye, Faye, Diallo, Sall) Institut Pasteur de Dakar, Dakar, Senegal (Freire, Iamarino, de Oliveira, Zanotto) Laboratory of Molecular Evolution and Bioinformatics, Department of Microbiology, Biomedical Sciences Institute, University of Sao Paulo, Sao Paulo, Brazil, A. A. Sall, Institut Pasteur de Dakar, Dakar, Senegal. E-mail: asall@pasteur.sn",,,,,"Aedes, Africa, article, disease re-emergence, epidemic, Flavivirus, glycosylation, human, immunofluorescence, molecular epidemiology, molecular evolution, nucleotide sequence, phylogeny, reverse transcription polymerase chain reaction, RNA extraction, virus recombination, virus strain, zika flavivirus, virus envelope protein","Zika virus (ZIKV) is a mosquito-borne flavivirus first isolated in Uganda in 1947. Although entomological and virologic surveillance have reported ZIKV enzootic activity in diverse countries of Africa and Asia, few human cases were reported until 2007, when a Zika fever epidemic took place in Micronesia. In the context of West Africa, the WHO Collaborating Centre for Arboviruses and Hemorrhagic Fever at Institut Pasteur of Dakar (<ext-link ext-link-type='uri' xlink:href='http://www.pasteur.fr/recherche/banques/CRORA/' xlink:type='simple' xmlns:xlink='http://www.w3.org/1999/xlink'>http://www.pasteur.fr/recherche/banques/CRORA/</ext-link>) reports the periodic circulation of ZIKV since 1968. Despite several reports on ZIKV, the genetic relationships among viral strains from West Africa remain poorly understood. To evaluate the viral spread and its molecular epidemiology, we investigated 37 ZIKV isolates collected from 1968 to 2002 in six localities in Senegal and Cote d'Ivoire. In addition, we included strains from six other countries. Our results suggested that these two countries in West Africa experienced at least two independent introductions of ZIKV during the 20<sup>th</sup> century, and that apparently these viral lineages were not restricted by mosquito vector species. Moreover, we present evidence that ZIKV has possibly undergone recombination in nature and that a loss of the N154 glycosylation site in the envelope protein was a possible adaptive response to the Aedes dalzieli vector. © 2014 Faye et al.",Embase,March 31, 2016,No,Duplicate of existing record,,,,,,,,,,
183,"Stramer, Vox Sanguinis, 2014",Stramer,"Stramer, S. L., Dodd, R. Y.",Progress in infectious disease testing-NAT and beyond,Vox Sanguinis,107,,5,2014,2010-present,,71500956,http://dx.doi.org/10.1111/vox.12153,1654,English,http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emed12&AN=71500956,"(Stramer, Dodd) American Red Cross, Gaithersburg, MD, United States, S.L. Stramer, American Red Cross, Gaithersburg, MD, United States",,,,,"society, blood transfusion, hematology, organization, infection, technology, pathogenesis, algorithm, blood, serology, risk, transfusion, epidemiology, virus, book, voice, screening, blood donor, Western Hemisphere, chronicity, Human immunodeficiency virus, Central America, assay, safety, clinical trial (topic), Babesia, Chikungunya alphavirus, parasite, erythrocyte, syphilis, chikungunya, landscape, dengue, Arbovirus, Parvovirus, blood safety, nucleic acid, marker, protein","Aims: To update membership on state-of-the-art testing technologies for infectious disease blood donation screening including new methods such as expanding NAT platforms, and nucleic acid and protein microarrays. Changes to testing algorithms with the availability of inactivation by pathogen reduction will also be highlighted. Background: Testing donated blood for markers of infectious disease plays a major role in establishing and maintaining blood safety. Minimal expectations worldwide are that blood is tested for syphilis, HIV, HCV and HBV. The norm for viral testing has been serology, but increasingly, nucleic acid testing is being implemented where resources allow, even for emerging infectious disease (EID) agents such as the chikungunya virus outbreak that started in Dec 2013 in the Caribbean, marking the first introduction of this virus in the Americas. The appropriate mix of tests and algorithms will depend on local epidemiology, infrastructure and economic considerations. Although NAT will detect acute infections, representing the greatest infectious threat, not all pathogens have adequate concentrations of nucleic acid for detection in the early acute or later chronic phases of infection (if chronicity is a feature of infection). Thus, for many agents, either serology only or a combination of serology and NAT exist. In developing test strategies, it is important to understand the actual risk of transfusion transmission and the impact of the test systems on such risk, especially where resources are limited. Methods: NAT has been implemented in over 30 nations worldwide as documented by an International Forum organized by the ISBT Transfusion-Transmitted Infectious Disease Working Party that captured implementation from 1999 to 2009 for HCV, HIV and HBV (Roth et al., Vox Sang 2012;102:82-90). Testing has progressed from manual technologies using single markers to highly multiplexed automated assays. Routine NAT has been added, either as a required marker or under investigational studies for additional agents including, parvovirus B19, HAV, HEV, arboviruses including WNV, dengue, chikungunya and Zika virus, the red-cell parasite, Babesia, and likely others. In addition to NAT, new technologies including pathogen reduction, and nucleic acid and protein microarrays will have an important impact on testing. Recently, the AABB EID working group has updated a listing of pathogen reduction technologies available including over 40 clinical trials in support of their safety and efficacy (http://www.aabb.org/resources/bct/eid/Pages/eidpostpub.aspx). The impact is either to prevent the need to introduce new tests, assuming availability of the technology to inactivate the component in which the agent is transmitted, and that the technology has sufficient robustness to produce an effective 'kill'. As an additional benefit, changes to existing testing algorithms may be feasible such that redundant tests may be eliminated. With respect to nucleic acid and protein microarrays, technological advances will allow the simultaneous detection and differentiation of hundreds of pathogens, but many hurdles prior to routine adoption exist. Conclusions: Blood systems worldwide must be ready to adapt to changes in their infectious disease epidemiology, emergence of new agents, and changes in their economic conditions and public expectations to accommodate the changing landscape of infectious disease testing.",Embase,March 31, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Review,No,Yes,183,Basic and applied biomedical research,Basic research review
184,"ECDC, , 2014",ECDC,ECDC,"Rapid risk assessment. Zika virus infection outbreak , French Polynesia - 14 February 2014",,,,,2014,2010-present,,,,1866,,,,Sweden,Europe,,Public/Government,,"Public health issue This document assesses the risk associated with the outbreak of Zika virus infections, considered as an emerging disease, to public health in the EU/EEA and the risk to EU/EEA citizens in order to anticipate future developments. The aim of this risk assessment is to summarise all available evidence on Zika virus epidemiology and disease presentation, and to assess the current outbreak of Zika in French Polynesia in view of this information, including the possible association with neurological and autoimmune complications.",ECDC,March 31, 2016,Yes,,No,"Zika, indirect evidence or other topic",Surveillance report or data,,,No,Yes,184,Clinical/epidemiological research,Ecological study/outbreak report
185,"Cao-Lormeau, Emerg Infect Dis, 2014",Cao-Lormeau,"Cao-Lormeau, V. M.","RE: Zika Virus, French Polynesia, South Pacific, 2013",Emerg Infect Dis,20,11,,2014,2010-present,,2014847297,http://dx.doi.org/10.3201/eid2011.141380,1635,English,"http://wwwnc.cdc.gov/eid/article/20/11/pdfs/14-1253.pdf, http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emed12&AN=2014847297","(Cao-Lormeau) Institut Louis Malarde, PO Box 30, Papeete, Tahiti 98713, France, V.-M. Cao-Lormeau, Institut Louis Malarde, PO Box 30, Papeete, Tahiti 98713, France",,,,,"Dengue virus, epidemic, Flavivirus, human, laboratory test, letter, nonhuman, virus infection, zika virus",,Embase,March 31, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,185,,
186,"Frieden, Lancet, 2014",Frieden,"Frieden, T. R., Tappero, J. W., Dowell, S. F., Hien, N. T., Guillaume, F. D., Aceng, J. R.",Safer countries through global health security,Lancet,383,9919,764-766,2014,2010-present,,332000000000,10.1016/S0140-6736(14)60189-6,1901,English,<Go to ISI>://:000332398700008,"Ctr Dis Control & Prevent, Atlanta, GA 30333 USA, Natl Inst Hyg & Epidemiol, Hanoi, Vietnam, Minist Hlth & Populat, Port Au Prince, Haiti, Minist Hlth, Kampala, Uganda",,,,,"public-health, implementation, postearthquake, capacity, haiti",,Lancet,March 31, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,186,,
187,"Chen, F1000Res, 2014",Chen,"Chen, S., Luetje, C. W.",Trace amines inhibit insect odorant receptor function through antagonism of the co-receptor subunit,F1000Res,3,,84,2014,2010-present,,25075297,10.12688/f1000research.3825.1,1842,,http://www.ncbi.nlm.nih.gov/pubmed/25075297,"Department of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, FL, 33101, USA.",,,,,,"Many insect behaviors are driven by olfaction, making insect olfactory receptors (ORs) appealing targets for insect control. Insect ORs are odorant-gated ion channels, with each receptor thought to be composed of a representative from a large, variable family of odorant binding subunits and a highly conserved co-receptor subunit (Orco), assembled in an unknown stoichiometry. Synthetic Orco directed agonists and antagonists have recently been identified. Several Orco antagonists have been shown to act via an allosteric mechanism to inhibit OR activation by odorants. The high degree of conservation of Orco across insect species results in Orco antagonists having broad activity at ORs from a variety of insect species and suggests that the binding site for Orco ligands may serve as a modulatory site for compounds endogenous to insects or may be a target of exogenous compounds, such as those produced by plants. To test this idea, we screened a series of biogenic and trace amines, identifying several as Orco antagonists. Of particular interest were tryptamine, a plant-produced amine, and tyramine, an amine endogenous to the insect nervous system. Tryptamine was found to be a potent antagonist of Orco, able to block Orco activation by an Orco agonist and to allosterically inhibit activation of ORs by odorants. Tyramine had effects similar to those of tryptamine, but was less potent. Importantly, both tryptamine and tyramine displayed broad activity, inhibiting odorant activation of ORs of species from three different insect orders (Diptera, Lepidoptera and Coleoptera), as well as odorant activation of six diverse ORs from a single species (the human malaria vector mosquito, Anopheles gambiae). Our results suggest that endogenous and exogenous natural compounds serve as Orco ligands modulating insect olfaction and that Orco can be an important target for the development of novel insect repellants.",F1000,March 31, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Original research,No,Yes,187,Basic and applied biomedical research,In vitro experiment
188,"Kutsuna, Eurosurveillance, 2014",Kutsuna,"Kutsuna, S., Kato, Y., Takasaki, T., Moi, M. L., Kotaki, A., Uemura, H., Matono, T., Fujiya, Y., Mawatari, M., Takeshita, N., Hayakawa, K., Kanagawa, S., Ohmagari, N.","Two cases of zika fever imported from french polynesia to Japan, December to January 2013",Eurosurveillance,19,4,,2014,2010-present,,2014085030,,1646,English,"http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=20683, http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emed12&AN=2014085030","(Kutsuna, Kato, Uemura, Matono, Fujiya, Mawatari, Takeshita, Hayakawa, Kanagawa, Ohmagari) National Center for Global health and Medicine, Disease Control and Prevention Center, Tokyo, Japan (Takasaki, Moi, Kotaki) Department of Virology 1, National Institute of Infectious Diseases, Shinjukuku, Tokyo, Japan, National Center for Global health and Medicine, Disease Control and Prevention Center, Tokyo, Japan",,,,,"adult, arthralgia, article, epidemic, female, French Polynesia, headache, human, import disease/ep [Epidemiology], Japan, leukopenia, male, nucleotide sequence, phylogeny, rash, real time polymerase chain reaction, reverse transcription polymerase chain reaction, thrombocytopenia, virus infection/ep [Epidemiology], young adult, zika fever/ep [Epidemiology]","We present two cases of imported Zika fever to Japan, in travellers returning from French Polynesia, where an outbreak due to Zika virus (ZIKV) is ongoing since week 41 of 2013. This report serves to raise awareness among healthcare professionals, that the differential diagnosis of febrile and subfebrile patients with rash should include ZIKV infection, especially in patients returning from areas affected by this virus.",Embase,March 31, 2016,No,Duplicate of existing record,,,,,,,,,,
189,"Tsegaye, Am J Trop Med Hyg, 2014",Tsegaye,"Tsegaye, M. M.",Virological and serological investigation of the first dengue fever outbreak in Ethiopia,Am J Trop Med Hyg,1),,53,2014,2010-present,,,,1652,English,"http://www.ajtmh.org/content/91/5_Suppl_1/1.1.full.pdf+html, http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emed12&AN=71691404","(Tsegaye) Ethiopian Public Health Institute, Addis Ababa, Ethiopia, M.M. Tsegaye, Ethiopian Public Health Institute, Addis Ababa, Ethiopia",,,,,"Ethiopia, society, tropical medicine, hygiene, dengue, laboratory, Dengue virus, virus, diseases, infection, Rift Valley fever, yellow fever, serum, Arbovirus, human, patient, Crimean Congo hemorrhagic fever, Flavivirus, chikungunya, Chikungunya alphavirus, public health, enzyme linked immunosorbent assay, convalescence, city, serotyping, health care facility, etiology, mosquito, immunoglobulin M, nucleic acid","Dengue fever is transmitted by the bite of a mosquito infected with one of the four dengue virus serotypes. In recent years, transmission has increased predominantly and has become a major international public health concern. In Ethiopia Dengue Fever has never been reported or laboratory confirmed previously. Unusual increment of febrile cases of unknown etiology was reported from Dire Dawa town, in eastern Ethiopia, in September 2013. Serological and virological investigations were carried to confirm or refute if arbo-viruses is the causative agent of the outbreak. Fifty serum samples were obtained from acute febrile illness patients who visited health facilities and also active case search for patients in convalescent phase of illness. The laboratory investigation of the serum samples included testing for the presence of IgM against arbo-viruses; namely flavi viruses (Yellow fever, Dengue, West Nile and Zika viruses) and Rift Valley Fever, Crimean-Congo Hemorrhagic Fever and Chikungunya viruses by ELISA as well as PCR testing for the presence of viral nucleic acids and nested PCR for sero-typing of dengue viruses. The results of the laboratory investigation showed that 15 of the 50 tested samples were positive for IgM against Dengue infection by ELISA (30%) and 11 were also positive by PCR (22.0%), one case was positive by both techniques giving a total dengue infection positivity rate of 50%. Relatively lower rate of Flavi-virus cross reactive IgM positivity was also observed for yellow fever (22%), Westnile (20%), and Zika (10%) viruses as compared to dengue. None of the samples were positive for IgM against rift valley fever, Crimean-Congo Hemorrhagic Fever and Chikungunya. Except for dengue, none of samples were positive by PCR for the tested viruses. Serotyping of the virus revealed that the infection was caused by dengue virus sero type 2. It is evident from the laboratory investigation that the acute febrile illness outbreak was caused by Dengue fever virus sero type 2 and this is the first laboratory finding confirming the first dengue outbreak in Ethiopia.",Embase,March 31, 2016,No,No full-text obtained yet,,,Scientific (journal) article,Yes,Original research,No,Yes,189,Clinical/epidemiological research,Cross-sectional study
190,"InVS, Point Epidemiologique International. Virus Zika Polynésie 2013-2014, Ile de Yap, Micronésie 2007 - Janvier 2014, 2014",InVS,InVS,"Virus Zika Polynésie 2013-2014, Ile de Yap, Micronésie 2007 - Janvier 2014","Point Epidemiologique International. Virus Zika Polynésie 2013-2014, Ile de Yap, Micronésie 2007 - Janvier 2014",,,,2014,2010-present,,,,1889,,,,France,Europe,,Not reported/unknown,,,Institute de veille sanitaire,March 31, 2016,Yes,,Yes,,Surveillance report or data,,,Yes,No,167,Clinical/epidemiological research,Ecological study/outbreak report
191,"Althouse, Am J Trop Med Hyg, 2015",Althouse,"Althouse, B. M.; Hanley, K. A.; Diallo, M.; Sall, A. A.; Ba, Y.; Faye, O.; Diallo, D.; Watts, D. M.; Weaver, S. C.; Cummings, D. A.",Impact of climate and mosquito vector abundance on sylvatic arbovirus circulation dynamics in Senegal,Am J Trop Med Hyg,92,1,88-97,2015,2010-present,November 19, 2014,25404071,10.4269/ajtmh.13-0617,1394,English,http://www.ncbi.nlm.nih.gov/pubmed/25404071,"Santa Fe Institute, Santa Fe, New Mexico; Department of Biology, New Mexico State University, Las Cruces, New Mexico; Institut Pasteur de Dakar, Dakar, Senegal; Office of Research and Sponsored Projects, University of Texas, El Paso, Texas; Tropical Diseases and Department of Pathology, University of Texas Medical Branch, Galveston, Texas; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland althouse@santafe.edu.; Santa Fe Institute, Santa Fe, New Mexico; Department of Biology, New Mexico State University, Las Cruces, New Mexico; Institut Pasteur de Dakar, Dakar, Senegal; Office of Research and Sponsored Projects, University of Texas, El Paso, Texas; Tropical Diseases and Department of Pathology, University of Texas Medical Branch, Galveston, Texas; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.",,,,,Animals; *Arbovirus Infections/transmission/virology; *Climate; Culicidae/*virology; *Insect Vectors; Rain; Senegal/epidemiology,"Sylvatic arboviruses have been isolated in Senegal over the last 50 years. The ecological drivers of the pattern and frequency of virus infection in these species are largely unknown. We used time series analysis and Bayesian hierarchical count modeling on a long-term arbovirus dataset to test associations between mosquito abundance, weather variables, and the frequency of isolation of dengue, yellow fever, chikungunya, and Zika viruses. We found little correlation between mosquito abundance and viral isolations. Rainfall was a negative predictor of dengue virus (DENV) isolation but a positive predictor of Zika virus isolation. Temperature was a positive predictor of yellow fever virus (YFV) isolations but a negative predictor of DENV isolations. We found slight interference between viruses, with DENV negatively associated with concurrent YFV isolation and YFV negatively associated with concurrent isolation of chikungunya virus. These findings begin to characterize some of the ecological associations of sylvatic arboviruses with each other and climate and mosquito abundance.",Pubmed,March 31, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Original research,No,Yes,191,Environmental and vector research,Ecological/vector modelling
192,"Gourinat, Emerg Infect Dis, 2015",Gourinat,"Gourinat, A. C.; O'Connor, O.; Calvez, E.; Goarant, C.; Dupont-Rouzeyrol, M.",Detection of Zika virus in urine,Emerg Infect Dis,21,1,84-6,2015,2010-present,December 23, 2014,25530324,10.3201/eid2101.140894,1392,English,http://www.ncbi.nlm.nih.gov/pubmed/25530324,,,,,,"Humans; *Molecular Diagnostic Techniques; RNA, Viral/*urine; Reverse Transcriptase Polymerase Chain Reaction; Zika Virus/genetics/*isolation & purification; *Zika Virus Infection/diagnosis/urine","We describe the kinetics of Zika virus (ZIKV) detection in serum and urine samples of 6 patients. Urine samples were positive for ZIKV >10 days after onset of disease, which was a notably longer period than for serum samples. This finding supports the conclusion that urine samples are useful for diagnosis of ZIKV infections.",Pubmed,March 31, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Original research,No,Yes,192,Clinical/epidemiological research,Case series
193,"Derraik, Aust N Z J Public Health, 2015",Derraik,"Derraik, J. G.; Slaney, D.",Notes on Zika virus--an emerging pathogen now present in the South Pacific,Aust N Z J Public Health,39,1,05. Jul,2015,2010-present,January 7, 2015,25559142,10.1111/1753-6405.12302,1390,English,http://www.ncbi.nlm.nih.gov/pubmed/25559142,"Liggins Institute, University of Auckland, New Zealand.",,,,,,,Pubmed,March 31, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,193,,
194,"Zammarchi, J Clin Virol, 2015",Zammarchi,"Zammarchi, L., Stella, G., Mantella, A., Bartolozzi, D., Tappe, D., Gunther, S., Oestereich, L., Cadar, D., Munoz-Fontela, C., Bartoloni, A., Schmidt-Chanasit, J.","Zika virus infections imported to Italy: clinical, immunological and virological findings, and public health implications",J Clin Virol,63,,32-5,2015,2010-present,January 21, 2015,25600600,10.1016/j.jcv.2014.12.005,1389,English,,"Clinica Malattie Infettive, Dipartimento di Medicina Sperimentale e Clinica, Universita Degli Studi di Firenze, Largo Brambilla 3, 50134 Firenze, Italy. Electronic address: lorenzo.zammarchi@unifi.it., Clinica Malattie Infettive, Dipartimento di Medicina Sperimentale e Clinica, Universita Degli Studi di Firenze, Largo Brambilla 3, 50134 Firenze, Italy. Electronic address: giulia.stella441@gmail.com., Clinica Malattie Infettive, Dipartimento di Medicina Sperimentale e Clinica, Universita Degli Studi di Firenze, Largo Brambilla 3, 50134 Firenze, Italy. Electronic address: antoniamantella@libero.it., SOD Malattie Infettive e Tropicali, Azienda Ospedaliero-Universitaria Careggi, Largo Brambilla 3, 50134 Firenze, Italy. Electronic address: bartolozzid@aou-careggi.toscana.it., Bernhard Nocht Institute for Tropical Medicine, WHO Collaborating Centre for Arbovirus and Haemorrhagic Fever Reference and Research, National Reference Centre for Tropical Infectious Diseases, Bernhard-Nocht-Strasse 74, 20359 Hamburg, Germany. Electronic address: tappe@bnitm.de., Bernhard Nocht Institute for Tropical Medicine, WHO Collaborating Centre for Arbovirus and Haemorrhagic Fever Reference and Research, National Reference Centre for Tropical Infectious Diseases, Bernhard-Nocht-Strasse 74, 20359 Hamburg, Germany. Electronic address: guenther@bnitm.de., Bernhard Nocht Institute for Tropical Medicine, WHO Collaborating Centre for Arbovirus and Haemorrhagic Fever Reference and Research, National Reference Centre for Tropical Infectious Diseases, Bernhard-Nocht-Strasse 74, 20359 Hamburg, Germany. Electronic address: oestereich@bnitm.de., Bernhard Nocht Institute for Tropical Medicine, WHO Collaborating Centre for Arbovirus and Haemorrhagic Fever Reference and Research, National Reference Centre for Tropical Infectious Diseases, Bernhard-Nocht-Strasse 74, 20359 Hamburg, Germany. Electronic address: cadar@bnitm.de., Bernhard Nocht Institute for Tropical Medicine, WHO Collaborating Centre for Arbovirus and Haemorrhagic Fever Reference and Research, National Reference Centre for Tropical Infectious Diseases, Bernhard-Nocht-Strasse 74, 20359 Hamburg, Germany; Heinrich Pette Institute, Leibniz Institute for Experimental Virology, Martinistrasse 52, 20251 Hamburg, Germany. Electronic address: cesar.munoz-fontela@hpi.uni-hamburg.de., Clinica Malattie Infettive, Dipartimento di Medicina Sperimentale e Clinica, Universita Degli Studi di Firenze, Largo Brambilla 3, 50134 Firenze, Italy; SOD Malattie Infettive e Tropicali, Azienda Ospedaliero-Universitaria Careggi, Largo Brambilla 3, 50134 Firenze, Italy. Electronic address: alessandro.bartoloni@unifi.it., Bernhard Nocht Institute for Tropical Medicine, WHO Collaborating Centre for Arbovirus and Haemorrhagic Fever Reference and Research, National Reference Centre for Tropical Infectious Diseases, Bernhard-Nocht-Strasse 74, 20359 Hamburg, Germany; German Centre for Infection Research (DZIF), Partner Site Hamburg-Luebeck-Borstel, Hamburg, Germany. Electronic address: jonassi@gmx.de.",Italy,Europe,Germany,,"Adult, Animals, Female, Humans, Italy/epidemiology, Leukocytes/immunology, Male, *Molecular Diagnostic Techniques, Polynesia, RNA, Viral/blood, *Serologic Tests, *Travel, Zika Virus Infection/*diagnosis/immunology/*pathology/virology, Dengue, Immunity, Italy, Travel, Zika","We report the first two cases of laboratory confirmed Zika virus (ZIKV) infections imported into Italy from French Polynesia. Both patients presented with low grade fever, malaise, conjunctivitis, myalgia, arthralgia, ankle oedema, and axillary and inguinal lymphadenopathy. One patient showed leukopenia with relative monocytosis and thrombocytopenia. The diagnosis was based on ZIKV seroconversion in both cases and on ZIKV RNA detection in one patient from acute serum sample. Sera from both patients exhibited cross-reactivity with dengue virus antigens. Our immunological analysis demonstrated that recovery from ZIKV infection is associated with restoration of normal numbers of immune cells in the periphery as well as with normal function of antigen-presenting cells. ZIKV is an emerging arbovirus, which has recently spread extensively in tourist destinations on several West Pacific islands. Returning viremic travelers may ignite autochthonous infections in countries like Italy, which are infested by Aedes albopictus, a suitable vector for ZIKV. The role of clinicians is crucial and includes early diagnosis and timely notification of public health authorities in order to quickly implement adequate focal vector control measurements.",Pubmed,March 31, 2016,Yes,,No,"Zika, not relevant to causality framework",Scientific (journal) article,Yes,Original research,No,Yes,194,Clinical/epidemiological research,Case series
195,"Dupont-Rouzeyrol, Emerg Infect Dis, 2015",Dupont-Rouzeyrol,"Dupont-Rouzeyrol, M.; O'Connor, O.; Calvez, E.; Daures, M.; John, M.; Grangeon, J. P.; Gourinat, A. C.","Co-infection with Zika and dengue viruses in 2 patients, New Caledonia, 2014",Emerg Infect Dis,21,2,381-2,2015,2010-present,January 28, 2015,25625687,10.3201/eid2102.141553,1388,English,http://www.ncbi.nlm.nih.gov/pubmed/25625687,"Center for Biomedical and Basic Technology of Health, National Institute of Health Research and Development, Ministry of Health, Republic of Indonesia, Jl. Percetakan Negara 23, Jakarta Pusat 16417 Indonesia; email: masrimaha@yahoo.com",New Caledonia,Pacific,New Caledonia,,"Adolescent; Adult; *Coinfection; Dengue/complications/*virology; *Dengue Virus/genetics; Disease Outbreaks; Female; Genes, Viral; Humans; Male; New Caledonia/epidemiology; Sequence Analysis, DNA; *Zika Virus/genetics; Zika Virus Infection/complications/*virology",,Pubmed,March 31, 2016,Yes,,No,"Zika, indirect evidence or other topic",Scientific (journal) article,Unknown/unclear,Original research,No,Yes,195,Clinical/epidemiological research,Case series
196,"Musso, Emerg Infect Dis, 2015",Musso,"Musso, D., Roche, C., Robin, E., Nhan, T., Teissier, A., Cao-Lormeau, V. M.",Potential sexual transmission of Zika virus,Emerg Infect Dis,21,2,359-61,2015,2010-present,January 28, 2015,25625872,10.3201/eid2102.141363,1387,English,,,,,,,"Adult, Disease Outbreaks, Female, Humans, Male, Polynesia/epidemiology, *Sexually Transmitted Diseases, Viral/epidemiology, Zika Virus/genetics/*isolation & purification, Zika Virus Infection/epidemiology/*transmission/*virology","In December 2013, during a Zika virus (ZIKV) outbreak in French Polynesia, a patient in Tahiti sought treatment for hematospermia, and ZIKV was isolated from his semen. ZIKV transmission by sexual intercourse has been previously suspected. This observation supports the possibility that ZIKV could be transmitted sexually.",Pubmed,March 31, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Original research,No,Yes,196,Clinical/epidemiological research,Case report
197,"Keighley, Curr Opin Infect Dis, 2015",Keighley,"Keighley, C. L., Saunderson, R. B., Kok, J., Dwyer, D. E.",Viral exanthems,Curr Opin Infect Dis,28,2,139-50,2015,2010-present,February 24, 2015,25706914,10.1097/qco.0000000000000145,1386,English,,"aCentre for Infectious Diseases and Microbiology Laboratory Services, Institute of Clinical Pathology and Medical Research, Pathology West, Westmead Hospital, Westmead bDepartment of Medicine, University of Sydney cMarie Bashir Institute for Infectious Diseases and Biosecurity dCentre for Research Excellence in Critical Infections, University of Sydney, Westmead Hospital, Westmead, New South Wales, Australia.",,,,,"Diagnostic Tests, Routine/*methods, Exanthema/*diagnosis/*epidemiology/virology, Global Health, Humans, Virus Diseases/*diagnosis/*epidemiology/virology, Viruses/*isolation & purification","PURPOSE OF REVIEW: Determining the viral cause of a rash presents significant diagnostic challenges. We review contemporary literature on viral exanthems and suggest a structured approach to aid diagnosis. RECENT FINDINGS: Strains responsible for, and the clinical presentation of, enteroviral infections have diverged from classic descriptions. The causative relationship between antibiotic administration and rash in Epstein-Barr virus infection has been recently questioned. Major measles virus outbreaks have recently occurred in Europe and the USA. The largest Ebola virus outbreak in West Africa has resulted in importation of the virus to other countries and secondary local transmission. Autochthonous transmission of Chikungunya virus has occurred in nonendemic areas, including Europe, the Caribbean and Americas. Zika virus has re-emerged in the Pacific with local transmission from imported cases. Climate change, global warming and spillover of zoonotic viruses are contributing to the emergence and spread of viral diseases. SUMMARY: Important clues to the diagnosis of viral exanthems include their distribution and morphology, geographic location and potential exposure to vector-borne or blood-borne viruses. Diagnosis is commonly made via serology, nucleic acid tests or, rarely, viral culture. Skin biopsy is not usually required. In general, viral exanthems are self-limiting and treatment is supportive.",Pubmed,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Yes,Review,No,Yes,197,Clinical/epidemiological research,Epidemiological/clinical review
198,"Babaniyi, J Glob Infect Dis, 2015",Babaniyi,"Babaniyi, O. A., Mwaba, P., Mulenga, D., Monze, M., Songolo, P., Mazaba-Liwewe, M. L., Mweene-Ndumba, I., Masaninga, F., Chizema, E., Eshetu-Shibeshi, M., Malama, C., Rudatsikira, E., Siziya, S.",Risk assessment for yellow Fever in Western and north-Western provinces of zambia,J Glob Infect Dis,7,1,11. Jul,2015,2010-present,February 28, 2015,25722614,10.4103/0974-777x.150884,1385,English,,"Zambia Country Office, World Health Organization, Lusaka, Zambia., Permanent Secretary Office, Ministry of Home Affairs, Lusaka, Zambia., Department of Clinical Sciences, School of Medicine, Copperbelt University, Ndola, Zambia., Department of Pathology and Microbiology, University Teaching Hospital, Lusaka, Zambia., Department of Disease Prevention and Control, World Health Organization, Lusaka, Zambia., Department of Pathology and Microbiology, University Teaching Hospital, Lusaka, Zambia ; Department of Immunization Vaccines and Emergencies, World Health Organization, Lusaka, Zambia., Department of Malaria, World Health Organization, Lusaka, Zambia., Department of Public Health Surveillance and Research, Ministry of Health, Lusaka, Zambia., Department of Inter-country Support Team, World Health Organization, Harare, Zimbabwe., Deans Office, School of Health Professions, Andrews University, Michigan, USA., Department of Clinical Sciences, School of Medicine, Copperbelt University, Ndola, Zambia ; Department of Public Health, School of Health Sciences, University of Lusaka, Lusaka, Zambia.",Zambia,Africa,Zambia,Not reported/unknown,"Prevalence, Western and North-Western provinces, Zambia, yellow fever","BACKGROUND: North-Western and Western provinces of Zambia were reclassified as low-risk areas for yellow fever (YF). However, the current potential for YF transmission in these areas is unclear. AIMS: To determine the current potential risk of YF infection. SETTING AND DESIGN: A cross sectional study was conducted in North-Western and Western provinces of Zambia. MATERIALS AND METHODS: Samples were tested for both YF virus-specific IgG and IgM antibodies by the ELISA and YF virus confirmation was done using Plaque Reduction Neutralization Test. The samples were also tested for IgG and IgM antibodies against other flaviviruses. RESULTS: Out of the 3625 respondents who participated in the survey, 46.7% were males and 9.4% were aged less than 5 years. Overall, 58.1% of the participants slept under an impregnated insecticide-treated net and 20.6% reported indoor residual spraying of insecticides. A total of 616 (17.0%) samples were presumptive YF positive. The prevalence for YF was 0.3% for long-term infection and 0.2% for recent YF infection. None of the YF confirmed cases had received YF vaccine. Prevalence rates for other flaviviruses were 149 (4.1%) for Dengue, 370 (10.2%) for West Nile and 217 (6.0%) for Zika. CONCLUSION: There is evidence of past and recent infection of YF in both provinces. Hence, they are at a low risk for YF infection. Yellow fever vaccination should be included in the EPI program in the two provinces and strengthen surveillance with laboratory confirmation.",Pubmed,March 31, 2016,Yes,,No,"Zika, indirect evidence or other topic",Scientific (journal) article,Yes,Original research,No,Yes,198,Clinical/epidemiological research,Cross-sectional study
199,"Alera, Emerg Infect Dis, 2015",Alera,"Alera, M. T., Hermann, L., Tac-An, I. A., Klungthong, C., Rutvisuttinunt, W., Manasatienkij, W., Villa, D., Thaisomboonsuk, B., Velasco, J. M., Chinnawirotpisan, P., Lago, C. B., Roque, V. G., Jr., Macareo, L. R., Srikiatkhachorn, A., Fernandez, S., Yoon, I. K.","Zika virus infection, Philippines, 2012",Emerg Infect Dis,21,4,722-4,2015,2010-present,March 27, 2015,25811410,10.3201/eid2104.141707,1384,English,,,,,,,"Adolescent, Genes, Viral, History, 21st Century, Humans, Male, Molecular Sequence Data, Philippines/epidemiology, Phylogeny, Population Surveillance, *Zika Virus/classification/genetics, Zika Virus Infection/*epidemiology/history/*virology, Philippines, Zika virus, viruses",,Pubmed,March 31, 2016,Yes,,No,"Zika, not relevant to causality framework",Scientific (journal) article,Yes,Original research,No,Yes,199,Basic and applied biomedical research,Sequence analysis and phylogenetics
200,"Tappe, Emerg Infect Dis, 2015",Tappe,"Tappe, D.; Nachtigall, S.; Kapaun, A.; Schnitzler, P.; Gunther, S.; Schmidt-Chanasit, J.","Acute Zika virus infection after travel to Malaysian Borneo, September 2014",Emerg Infect Dis,21,5,911-3,2015,2010-present,April 22, 2015,25898277,10.3201/eid2105.141960,1383,English,http://www.ncbi.nlm.nih.gov/pubmed/25898277,,Germany,Europe,Germany,Not reported/unknown,Borneo/epidemiology; Female; Germany; Humans; Middle Aged; Travel; Zika Virus/*isolation & purification; *Zika Virus Infection/diagnosis/transmission/virology; Borneo; Zika fever; Zika virus; hearing disorder; viruses,"Zika virus (ZIKV), a mosquito-borne flavivirus, causes Zika fever, a self-limiting febrile and exanthematic arthralgia syndrome closely resembling dengue fever. Most often, signs and symptoms are maculopapular rash, fever, arthralgia, myalgia, headache, and conjunctivitis; edema, sore throat, cough, and vomiting occur less frequently. We report an acute ZIKV infection in a traveler returning from Malaysian Borneo who experienced bilateral hearing difficulties during the course of illness. ",Pubmed,March 31, 2016,Yes,,No,"Zika, indirect evidence or other topic",Scientific (journal) article,Yes,Original research,No,Yes,200,Clinical/epidemiological research,Case report
201,"Summers, J Travel Med, 2015",Summers,"Summers, D. J., Acosta, R. W., Acosta, A. M.",Zika Virus in an American Recreational Traveler,J Travel Med,22,5,338-40,2015,2010-present,May 23, 2015,25996909,10.1111/jtm.12208,1382,English,,"Traveler's Medical Service of New York, New York, NY, USA., School of Nursing, Columbia University, New York, NY, USA., Department of Medicine, Weill Cornell Medical College and The New York-Presbyterian Hospital, New York, NY, USA.",,,,,,"We report the case of a 48-year-old American traveler who presented to our clinic with diffuse rash, malaise, fatigue, fever, arthralgia, low back pain, and bilateral exudative conjunctivitis. The patient had an extensive vaccination and travel history: most notable for prior receipt of yellow fever vaccine; extensive travel or residence in areas endemic for dengue, chikungunya, and West Nile virus; and recent travel to French Polynesia. Clinical and laboratory findings were consistent with Zika virus (ZIKV) infection. Our report highlights the need to include ZIKV in the differential diagnosis, especially in febrile patients with a rash returning from endemic areas.",Pubmed,March 31, 2016,Yes,,No,"Zika, not relevant to causality framework",Scientific (journal) article,Yes,Original research,No,Yes,201,Clinical/epidemiological research,Case report
202,"Zanluca, Mem Inst Oswaldo Cruz, 2015",Zanluca,"Zanluca, C.; Melo, V. C.; Mosimann, A. L.; Santos, G. I.; Santos, C. N.; Luz, K.",First report of autochthonous transmission of Zika virus in Brazil,Mem Inst Oswaldo Cruz,110,4,569-72,2015,2010-present,June 11, 2015,26061233,10.1590/0074-02760150192,1381,English,http://www.ncbi.nlm.nih.gov/pubmed/26061233,"Laboratorio de Virologia Molecular, Instituto Carlos Chagas, Fundacao Oswaldo Cruz, Curitiba, PR, Brasil.; Secretaria Estadual de Saude do Rio Grande do Norte, Natal, RN, Brasil.; Instituto de Medicina Tropical, Universidade Federal do Rio Grande do Norte, Natal, RN, Brasil.",,,,,"Adolescent; Adult; Aedes/*virology; Aged; Animals; Base Sequence; Brazil/epidemiology; Female; Humans; Insect Vectors/*virology; Male; Middle Aged; Phylogeny; Polymerase Chain Reaction; RNA, Viral; Sequence Analysis, DNA; Young Adult; Zika Virus/*genetics/isolation & purification; Zika Virus Infection/epidemiology/*transmission/virology","In the early 2015, several cases of patients presenting symptoms of mild fever, rash, conjunctivitis and arthralgia were reported in the northeastern Brazil. Although all patients lived in a dengue endemic area, molecular and serological diagnosis for dengue resulted negative. Chikungunya virus infection was also discarded. Subsequently, Zika virus (ZIKV) was detected by reverse transcription-polymerase chain reaction from the sera of eight patients and the result was confirmed by DNA sequencing. Phylogenetic analysis suggests that the ZIKV identified belongs to the Asian clade. This is the first report of ZIKV infection in Brazil.",Pubmed,March 31, 2016,Yes,,No,"Zika, not relevant to causality framework",Scientific (journal) article,Yes,Original research,No,Yes,202,Basic and applied biomedical research,Sequence analysis and phylogenetics
203,"Musso, J Clin Virol, 2015",Musso,"Musso, D.; Roche, C.; Nhan, T. X.; Robin, E.; Teissier, A.; Cao-Lormeau, V. M.",Detection of Zika virus in saliva,J Clin Virol,68,,53-5,2015,2010-present,June 14, 2015,26071336,10.1016/j.jcv.2015.04.021,1380,English,http://www.ncbi.nlm.nih.gov/pubmed/26071336,"Laboratoire de biologie medicale, Institut Louis Malarde, Tahiti, French Polynesia; Pole de recherche et de veille sur les maladies infectieuses emergentes, Institut Louis Malarde, Tahiti, French Polynesia. Electronic address: dmusso@ilm.pf.; Pole de recherche et de veille sur les maladies infectieuses emergentes, Institut Louis Malarde, Tahiti, French Polynesia. Electronic address: croche@ilm.pf.; Laboratoire de biologie medicale, Institut Louis Malarde, Tahiti, French Polynesia. Electronic address: tnhan@ilm.pf.; Laboratoire de biologie medicale, Institut Louis Malarde, Tahiti, French Polynesia. Electronic address: e.grange@cht.nc.; Pole de recherche et de veille sur les maladies infectieuses emergentes, Institut Louis Malarde, Tahiti, French Polynesia. Electronic address: ateissier@ilm.pf.; Pole de recherche et de veille sur les maladies infectieuses emergentes, Institut Louis Malarde, Tahiti, French Polynesia. Electronic address: mlormeau@ilm.pf.",,,,,"Adult; Blood/virology; Child; Child, Preschool; Humans; Infant; Polynesia; Reverse Transcriptase Polymerase Chain Reaction/methods; Saliva/*virology; Sensitivity and Specificity; Surveys and Questionnaires; Zika Virus/genetics/*isolation & purification; Zika Virus Infection/*diagnosis/*virology; Arbovirus; French Polynesia; Pcr; Saliva; Zikv; Zika","BACKGROUND: During the largest Zika virus (ZIKV) outbreak ever reported that occurred from October 2013 to March 2014 in French Polynesia, we observed that several patients presenting the symptoms of acute phase Zika fever were tested negative in blood by ZIKV real-time PCR (RT-PCR). OBJECTIVES: As we have previously detected ZIKV RNA in the saliva of a young child, we investigated the use of saliva as an alternative sample for routine ZIKV RNA detection. STUDY DESIGN: Over a 6 month period, 1,067 samples collected from 855 patients presenting symptoms of Zika fever (saliva only, blood only or both samples) were tested using a specific ZIKV RT-PCR. A medical questionnaire was available for most of the patients. RESULTS: ZIKV was more frequently detected in saliva compared to blood. For the 182 patients with both samples collected, tests were positive for 35 (19.2%) in saliva while negative in blood and tests were positive for 16 (8.8%) in blood while negative in saliva; the difference in mean days after symptoms onset and the percentage of the main symptoms of Zika fever for patients only positive in saliva or in blood was not significant. CONCLUSION: The use of saliva sample increased the rate of molecular detection of ZIKV at the acute phase of the disease but did not enlarge the window of detection of ZIKV RNA. Saliva was of particular interest when blood was difficult to collect (children and neonates especially).",Pubmed,March 31, 2016,Yes,,No,"Zika, not relevant to causality framework",Scientific (journal) article,Yes,Original research,No,Yes,203,Clinical/epidemiological research,Cohort study
204,"Hamel, J Virol, 2015",Hamel,"Hamel, R.; Dejarnac, O.; Wichit, S.; Ekchariyawat, P.; Neyret, A.; Luplertlop, N.; Perera-Lecoin, M.; Surasombatpattana, P.; Talignani, L.; Thomas, F.; Cao-Lormeau, V. M.; Choumet, V.; Briant, L.; Despres, P.; Amara, A.; Yssel, H.; Misse, D.",Biology of Zika Virus Infection in Human Skin Cells,J Virol,89,17,8880-96,2015,2010-present,June 19, 2015,26085147,10.1128/JVI.00354-15,1378,English,http://www.ncbi.nlm.nih.gov/pubmed/26085147,"Laboratoire MIVEGEC, UMR 224 IRD/CNRS/UM, Montpellier, France.; INSERM, U944, Laboratoire de Pathologie et Virologie Moleculaire, Paris, France.; Centre d'Etude d'Agents Pathogenes et Biotechnologies pour la Sante, CNRS-UMR 5236/UM, Montpellier, France.; Department of Microbiology and Immunology, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.; Pathology Department, Prince of Songkla University, Songkla, Thailand.; Institut Louis Malarde, Papeete, Tahiti, French Polynesia.; Environment and Infectious Risks Unit, Institut Pasteur, Paris, France.; Departement Infections et Epidemiologie, Institut Pasteur, Paris, France, and UMR PIMIT (I2T Team), Universite de La Reunion, INSERM U1187, CNRS 9192, IRD 249, GIP-CYROI, Saint Clotilde, La Reunion, France.; Centre d'Immunologie et des Maladies Infectieuses, INSERM, U1135, Sorbonne Universites, UPMC, APHP Hopital Pitie-Salpetriere, Paris, France.; Laboratoire MIVEGEC, UMR 224 IRD/CNRS/UM, Montpellier, France dorothee.misse@ird.fr.",France,Europe,France,Mixed,,"Zika virus (ZIKV) is an emerging arbovirus of the Flaviviridae family, which includes dengue, West Nile, yellow fever, and Japanese encephalitis viruses, that causes a mosquito-borne disease transmitted by the Aedes genus, with recent outbreaks in the South Pacific. Here we examine the importance of human skin in the entry of ZIKV and its contribution to the induction of antiviral immune responses. We show that human dermal fibroblasts, epidermal keratinocytes, and immature dendritic cells are permissive to the most recent ZIKV isolate, responsible for the epidemic in French Polynesia. Several entry and/or adhesion factors, including DC-SIGN, AXL, Tyro3, and, to a lesser extent, TIM-1, permitted ZIKV entry, with a major role for the TAM receptor AXL. The ZIKV permissiveness of human skin fibroblasts was confirmed by the use of a neutralizing antibody and specific RNA silencing. ZIKV induced the transcription of Toll-like receptor 3 (TLR3), RIG-I, and MDA5, as well as several interferon-stimulated genes, including OAS2, ISG15, and MX1, characterized by strongly enhanced beta interferon gene expression. ZIKV was found to be sensitive to the antiviral effects of both type I and type II interferons. Finally, infection of skin fibroblasts resulted in the formation of autophagosomes, whose presence was associated with enhanced viral replication, as shown by the use of Torin 1, a chemical inducer of autophagy, and the specific autophagy inhibitor 3-methyladenine. The results presented herein permit us to gain further insight into the biology of ZIKV and to devise strategies aiming to interfere with the pathology caused by this emerging flavivirus. IMPORTANCE: Zika virus (ZIKV) is an arbovirus belonging to the Flaviviridae family. Vector-mediated transmission of ZIKV is initiated when a blood-feeding female Aedes mosquito injects the virus into the skin of its mammalian host, followed by infection of permissive cells via specific receptors. Indeed, skin immune cells, including dermal fibroblasts, epidermal keratinocytes, and immature dendritic cells, were all found to be permissive to ZIKV infection. The results also show a major role for the phosphatidylserine receptor AXL as a ZIKV entry receptor and for cellular autophagy in enhancing ZIKV replication in permissive cells. ZIKV replication leads to activation of an antiviral innate immune response and the production of type I interferons in infected cells. Taken together, these results provide the first general insights into the interaction between ZIKV and its mammalian host.",Pubmed,March 31, 2016,Yes,,Yes,,Scientific (journal) article,Yes,Original research,No,Yes,204,Basic and applied biomedical research,In vitro experiment
205,"Zammarchi, Eurosurveillance, 2015",Zammarchi,"Zammarchi, L., Tappe, D., Fortuna, C., Remoli, M. E., Gunther, S., Venturi, G., Bartoloni, A., Schmidt-Chanasit, J.","Zika virus infection in a traveller returning to Europe from Brazil, March 2015",Eurosurveillance,20,23,,2015,2010-present,June 19, 2015,26084316,,1379,English,http://www.ncbi.nlm.nih.gov/pubmed/?term=26084316,"Clinica Malattie Infettive, Dipartimento di Medicina Sperimentale e Clinica, Universita Degli Studi di Firenze, Florence, Italy.",Italy,Europe,Germany,,"Antibodies, Viral/blood, Brazil, Exanthema/virology, Fever/virology, Humans, Immunoglobulin G/blood, Immunoglobulin M/blood, Italy, Male, Middle Aged, RNA, Viral/blood/genetics, Reverse Transcriptase Polymerase Chain Reaction, Travel, Zika Virus/genetics/immunology/*isolation & purification, *Zika Virus Infection/blood/diagnosis/virology","We report a case of laboratory-confirmed Zika virus infection imported into Europe from the Americas. The patient developed fever, rash, and oedema of hands and feet after returning to Italy from Brazil in late March 2015. The case highlights that, together with chikungunya virus and dengue virus, three major arboviruses are now co-circulating in Brazil. These arboviruses represent a burden for the healthcare systems in Brazil and other countries where competent mosquito vectors are present.",Pubmed,March 31, 2016,Yes,,No,"Zika, not relevant to causality framework",Scientific (journal) article,Yes,Original research,Yes,Yes,205,Clinical/epidemiological research,Case report
206,"Buathong, Am J Trop Med Hyg, 2015",Buathong,"Buathong, R.; Hermann, L.; Thaisomboonsuk, B.; Rutvisuttinunt, W.; Klungthong, C.; Chinnawirotpisan, P.; Manasatienkij, W.; Nisalak, A.; Fernandez, S.; Yoon, I. K.; Akrasewi, P.; Plipat, T.","Detection of Zika Virus Infection in Thailand, 2012-2014",Am J Trop Med Hyg,93,2,380-3,2015,2010-present,June 24, 2015,26101272,10.4269/ajtmh.15-0022,1377,English,http://www.ncbi.nlm.nih.gov/pubmed/26101272,"Department of Disease Control, Bureau of Epidemiology, Ministry of Public Health, Nonthaburi, Thailand; Department of Virology, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand; Department of Medicine, University of Toronto, Toronto, Ontario, Canada.; Department of Disease Control, Bureau of Epidemiology, Ministry of Public Health, Nonthaburi, Thailand; Department of Virology, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand; Department of Medicine, University of Toronto, Toronto, Ontario, Canada laura.hermann@afrims.org.",,,,,"Adolescent; Adult; Animals; Child; Culicidae/virology; *Disease Outbreaks; Female; Humans; Male; Middle Aged; Phylogeny; RNA, Viral; Thailand/epidemiology; Young Adult; Zika Virus/classification/*isolation & purification; *Zika Virus Infection/epidemiology/virology","Zika virus (ZIKV) is an emerging mosquito-borne pathogen with reported cases in Africa, Asia, and large outbreaks in the Pacific. No autochthonous ZIKV infections have been confirmed in Thailand. However, there have been several cases reported in travelers returning from Thailand. Here we report seven cases of acute ZIKV infection in Thai residents across the country confirmed by molecular or serological testing including sequence data. These endemic cases, combined with previous reports in travelers, provide evidence that ZIKV is widespread throughout Thailand.",Pubmed,March 31, 2016,Yes,,No,"Zika, not relevant to causality framework",Scientific (journal) article,Yes,Original research,No,Yes,206,Basic and applied biomedical research,Sequence analysis and phylogenetics
207,"Patino-Barbosa, Sex Transm Infect, 2015",Patino-Barbosa,"Patino-Barbosa, A. M., Medina, I., Gil-Restrepo, A. F., Rodriguez-Morales, A. J.",Zika: another sexually transmitted infection?,Sex Transm Infect,91,5,359,2015,2010-present,June 27, 2015,26113729,10.1136/sextrans-2015-052189,1376,English,,"Public Health and Infection Research and Incubator Group, Faculty of Health Sciences, Universidad Tecnologica de Pereira, Pereira, Risaralda, Colombia.",,,,,"Communicable Diseases, Emerging/epidemiology/*virology, Disease Outbreaks, Flavivirus/*pathogenicity, Flavivirus Infections/epidemiology/*virology, Global Health, Humans, Phylogeny, Semen/*virology, Sexually Transmitted Diseases/epidemiology/*virology, Epidemiology (general), Public health, Virology clinical, Virology general laboratory",,Pubmed,March 31, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,207,,
208,"Rodríguez-Morales, J Infect Dev Ctries, 2015",Rodríguez-Morales,"Rodríguez-Morales, A. J.",Zika: the new arbovirus threat for Latin America,J Infect Dev Ctries,9,6,684-5,2015,2010-present,July 6, 2015,26142684,10.3855/jidc.7230,1375,English,,The Journal of Infection in Developing Countries. arodriguez@jidc.org.,,,,,"*Disease Transmission, Infectious, Humans, *Infectious Disease Transmission, Vertical, Latin America/epidemiology, Zika Virus/*isolation & purification, Zika Virus Infection/*epidemiology/*transmission",,Pubmed,March 31, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,208,,
209,"Musso, Lancet, 2015",Musso,"Musso, D., Cao-Lormeau, V. M., Gubler, D. J.",Zika virus: following the path of dengue and chikungunya?,Lancet,386,9990,243-4,2015,2010-present,July 22, 2015,26194519,10.1016/s0140-6736(15)61273-9,1374,English,,"Unit of Emerging Infectious Diseases, Institut Louis Malarde, Tahiti, French Polynesia. Electronic address: dmusso@ilm.pf., Unit of Emerging Infectious Diseases, Institut Louis Malarde, Tahiti, French Polynesia., Program in Emerging Infectious Diseases, Duke-NUS Graduate Medical School, Singapore; Partnership for Dengue Control, Lyon, France.",,,,,"Brazil/epidemiology, Chikungunya Fever/epidemiology, Communicable Diseases, Emerging/*epidemiology, Dengue/epidemiology, *Disease Outbreaks, Global Health, Humans, Zika Virus Infection/*epidemiology",,Pubmed,March 31, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,209,,
210,"Kleinman, Curr Opin Hematol, 2015",Kleinman,"Kleinman, S.",Pathogen inactivation: emerging indications,Curr Opin Hematol,22,6,547-53,2015,2010-present,September 22, 2015,26390164,10.1097/moh.0000000000000186,1371,English,,"University of British Columbia, Vancouver, British Columbia, Canada.",,,,,,"PURPOSE OF REVIEW: To review data about transfusion-transmitted infections so as to assess potential safety benefits of applying pathogen inactivation technology to platelets. RECENT FINDINGS: Residual bacterial risk still exists. Multiple arbovirus epidemics continue to occur and challenge blood safety policy makers in nonendemic developed countries. There is new documentation of transfusion transmission of dengue and Ross River viruses, and new or increased concern about chikungunya and Zika viruses. Pathogen inactivation has been shown to inactivate almost all bacterial species and several epidemic arboviruses that pose a transfusion transmission risk. The two available platelet pathogen inactivation technologies show different levels of pathogen inactivation as measured by in-vitro infectivity assays; the clinical significance of this finding is not known. SUMMARY: Pathogen inactivation can mitigate infectious risk and should do so more completely than other interventions such as donor questioning, donor/component recall, or donor testing. However, pathogen inactivation increases the cost of the pathogen-reduced blood component, which is a significant obstacle in the current healthcare environment. This may inhibit the ability to move forward with an effective new paradigm for blood safety that fulfills the implicit public trust in the blood system.",Pubmed,March 31, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Review,No,Yes,210,Basic and applied biomedical research,Basic research review
211,"Campos, Emerg Infect Dis, 2015",Campos,"Campos, G. S., Bandeira, A. C., Sardi, S. I.","Zika Virus Outbreak, Bahia, Brazil",Emerg Infect Dis,21,10,1885-6,2015,2010-present,September 25, 2015,26401719,10.3201/eid2110.150847,1370,English,,,,,,,"Bahia, Brazil, Zika virus, detection, diagnosis, maculopapular rash, outbreak, reverse transcription PCR, viruses",,Pubmed,March 31, 2016,Yes,,No,"Zika, not relevant to causality framework",Scientific (journal) article,Yes,Original research,No,Yes,211,Basic and applied biomedical research,Sequence analysis and phylogenetics
212,"Musso, Emerg Infect Dis, 2015",Musso,"Musso, D.",Zika Virus Transmission from French Polynesia to Brazil,Emerg Infect Dis,21,10,1887,2015,2010-present,September 26, 2015,26403318,10.3201/eid2110.151125,1369,English,,,,,,,"Ae. aegypti, Ae. africanus, Ae. hensilli, Ae. luteocephalus, Aedes spp., Brazil, Cook Islands, Easter Island, French Polynesia, New Caledonia, Pacific Islands, Vanuatu, Zikv, Zika virus, arbovirus, mosquito, vector-borne infections, viruses",,Pubmed,March 31, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,No,Comment/Editorial/Perspective/Letter,No,Yes,212,,
213,"Aubry, Int J Infect Dis, 2015",Aubry,"Aubry, M., Finke, J., Teissier, A., Roche, C., Broult, J., Paulous, S., Despres, P., Cao-Lormeau, V. M., Musso, D.","Seroprevalence of arboviruses among blood donors in French Polynesia, 2011-2013",Int J Infect Dis,41,,11. Feb,2015,2010-present,October 21, 2015,26482390,10.1016/j.ijid.2015.10.005,1368,English,,"Unit of Emerging Infectious Diseases, Institut Louis Malarde, PO Box 30, 98713 Papeete, Tahiti, French Polynesia. Electronic address: maubry@ilm.pf., Hochschule Emden/Leer, Emden, Germany., Unit of Emerging Infectious Diseases, Institut Louis Malarde, PO Box 30, 98713 Papeete, Tahiti, French Polynesia., Centre de Transfusion Sanguine de la Polynesie Francaise, Hopital du Taaone, Papeete, Tahiti, French Polynesia., Unite Hepacivirus et Immunite Innee, Institut Pasteur, Paris, France., Unite Hepacivirus et Immunite Innee, Institut Pasteur, Paris, France; UMR PIMIT (12T) Universite de La Reunion, Sainte-Clotilde, France.",French Polynesia,Pacific,French Polynesia,Public/Government,"Arboviruses, Blood donors, Dengue, French Polynesia, Pacific, Seroprevalence","OBJECTIVES: French Polynesia is a high epidemic/endemic area for arthropod-borne viruses (arboviruses). We recently reported the silent circulation of Ross River virus and absence of active transmission of chikungunya virus (CHIKV) among blood donors sampled before the emergence of Zika virus (ZIKV) and CHIKV in French Polynesia. In this study, the prevalence of the four serotypes of dengue virus (DENV) and the occurrence of circulation of other arboviruses were investigated in blood donors in French Polynesia. METHODS: Serum samples from 593 blood donors collected between July 2011 and October 2013 were tested by ELISA for the presence of immunoglobulin G antibodies against each of the four DENV serotypes, ZIKV, Japanese encephalitis virus (JEV), and West Nile virus (WNV). RESULTS: It was found that 80.3%, 0.8%, 1.3%, and 1.5% of blood donors were seropositive for at least one DENV serotype, ZIKV, JEV, and WNV, respectively. CONCLUSIONS: These results corroborate the expected high transmission of DENV and conversely suggest that no active circulation of ZIKV, JEV, and WNV occurred in French Polynesia before 2011. Information provided by this study may be useful for public health authorities to improve surveillance and implement strategies to prevent the transmission of arboviruses.",Pubmed,March 31, 2016,Yes,,No,"Zika, indirect evidence or other topic",Scientific (journal) article,Yes,Original research,No,Yes,213,Clinical/epidemiological research,Cross-sectional study
214,"Leung, Southeast Asian J Trop Med Public Health, 2015",Leung,"Leung, G. H., Baird, R. W., Druce, J., Anstey, N. M.",Zika Virus Infection in Australia Following a Monkey Bite in Indonesia,Southeast Asian J Trop Med Public Health,46,3,460-4,2015,2010-present,November 3, 2015,26521519,,1367,English,,,,,,,"Adult, Animals, Australia, Base Sequence, Bites and Stings/*complications/*virology, Exanthema/etiology, Fever/etiology, Humans, Indonesia, Macaca/*virology, Male, Nasopharynx/virology, RNA, Viral, *Zika Virus/genetics, *Zika Virus Infection/diagnosis/etiology/transmission","A traveller returning to Australia developed Zika virus infection, with fever, rash and conjunctivitis, with onset five days after a monkey bite in Bali, Indonesia. Flavivirus RNA detected on PCR from a nasopharyngeal swab was sequenced and identified as Zika virus. Although mosquito-borne transmission is also possible, we propose the bite as a plausible route of transmission. The literature for non-vector transmissions of Zika virus and other flaviviruses is reviewed.",Pubmed,March 31, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Original research,No,Yes,214,Clinical/epidemiological research,Case report
215,"Diagne, BMC Infect Dis, 2015",Diagne,"Diagne, C. T., Diallo, D., Faye, O., Ba, Y., Faye, O., Gaye, A., Dia, I., Faye, O., Weaver, S. C., Sall, A. A., Diallo, M.",Potential of selected Senegalese Aedes spp. mosquitoes (Diptera: Culicidae) to transmit Zika virus,BMC Infect Dis,15,,492,2015,2010-present,November 4, 2015,26527535,10.1186/s12879-015-1231-2,1366,English,,"Unite d'Entomologie Medicale, Institut Pasteur de Dakar, 36 Avenue Pasteur, BP 220,, Dakar, Senegal. ctdiagne@pasteur.sn., Departement de Biologie Animale, Laboratoire d'Ecologie Vectorielle et Parasitaire, Universite Cheikh Anta Diop, Dakar, Senegal. ctdiagne@pasteur.sn., Unite d'Entomologie Medicale, Institut Pasteur de Dakar, 36 Avenue Pasteur, BP 220,, Dakar, Senegal. ddiallo@pasteur.sn., Unite des Arbovirus et Virus de Fievres Hemorragiques, Institut Pasteur de Dakar, 36 Avenue Pasteur, BP 220,, Dakar, Senegal. oumarfaye@pasteur.sn., Unite d'Entomologie Medicale, Institut Pasteur de Dakar, 36 Avenue Pasteur, BP 220,, Dakar, Senegal. ba@pasteur.sn., Unite des Arbovirus et Virus de Fievres Hemorragiques, Institut Pasteur de Dakar, 36 Avenue Pasteur, BP 220,, Dakar, Senegal. ofaye@pasteur.sn., Unite d'Entomologie Medicale, Institut Pasteur de Dakar, 36 Avenue Pasteur, BP 220,, Dakar, Senegal. agaye@pasteur.sn., Unite d'Entomologie Medicale, Institut Pasteur de Dakar, 36 Avenue Pasteur, BP 220,, Dakar, Senegal. dia@pasteur.sn., Departement de Biologie Animale, Laboratoire d'Ecologie Vectorielle et Parasitaire, Universite Cheikh Anta Diop, Dakar, Senegal. fayeo@orange.sn., Institute for Human Infections and Immunity, Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, TX, 77555-0610, USA. sweaver@utmb.edu., Department of Pathology and Microbiology & Immunology, University of Texas Medical Branch, Galveston, TX, 77555-0610, USA. sweaver@utmb.edu., Unite des Arbovirus et Virus de Fievres Hemorragiques, Institut Pasteur de Dakar, 36 Avenue Pasteur, BP 220,, Dakar, Senegal. asall@pasteur.sn., Unite d'Entomologie Medicale, Institut Pasteur de Dakar, 36 Avenue Pasteur, BP 220,, Dakar, Senegal. diallo@pasteur.sn.",,,,,,"BACKGROUND: Zika virus (ZIKV; genus Flavivirus, family Flaviviridae) is an emerging virus of medical importance maintained in a zoonotic cycle between arboreal Aedes spp. mosquitoes and nonhuman primates in African and Asian forests. Serological evidence and virus isolations have demonstrated widespread distribution of the virus in Senegal. Several mosquito species have been found naturally infected by ZIKV but little is known about their vector competence. METHODS: We assessed the vector competence of Ae. aegypti from Kedougou and Dakar, Ae. unilineatus, Ae. vittatus and Ae. luteocephalus from Kedougou in Senegal for 6 ZIKV strains using experimental oral infection. Fully engorged female mosquitoes were maintained in an environmental chamber set at 27 +/- 1 degrees C and 80 +/- 5% Relative humidity. At day 5, 10 and 15 days post infection (dpi), individual mosquito saliva, legs/wings and bodies were tested for the presence of ZIKV genome using real time RT-PCR to estimate the infection, dissemination, and transmission rates. RESULTS: All the species tested were infected by all viral strains but only Ae. vittatus and Ae. luteocephalus were potentially capable of transmitting ZIKV after 15 dpi with 20 and 50% of mosquitoes, respectively, delivering epidemic (HD 78788) and prototype (MR 766) ZIKV strains in saliva. CONCLUSION: All the species tested here were susceptible to oral infection of ZIKV but only a low proportion of Ae. vittatus and Ae. luteocephalus had the viral genome in their saliva and thus the potential to transmit the virus. Further investigations are needed on the vector competence of other species associated with ZIKV for better understanding of the ecology and epidemiology of this virus in Senegal.",Pubmed,March 31, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Original research,No,Yes,215,Environmental and vector research,Vector competence studies
216,"Cardoso, Emerg Infect Dis, 2015",Cardoso,"Cardoso, C. W., Paploski, I. A., Kikuti, M., Rodrigues, M. S., Silva, M. M., Campos, G. S., Sardi, S. I., Kitron, U., Reis, M. G., Ribeiro, G. S.","Outbreak of Exanthematous Illness Associated with Zika, Chikungunya, and Dengue Viruses, Salvador, Brazil",Emerg Infect Dis,21,12,2274-6,2015,2010-present,November 20, 2015,26584464,10.3201/eid2112.151167,1363,English,,,,,,,"Brazil, Salvador, Zika virus, acute exanthematous illness, arboviruses, chikungunya virus, dengue virus, disease outbreak, epidemiology, flavivirus, vectorborne infections, viruses",,Pubmed,March 31, 2016,Yes,,No,"Zika, not relevant to causality framework",Scientific (journal) article,Yes,Original research,No,Yes,216,Clinical/epidemiological research,Ecological study/outbreak report
217,"Roiz, J Med Entomol, 2015",Roiz,"Roiz, D., Duperier, S., Roussel, M., Bousses, P., Fontenille, D., Simard, F., Paupy, C.",Trapping the Tiger: Efficacy of the Novel BG-Sentinel 2 With Several Attractants and Carbon Dioxide for Collecting Aedes albopictus (Diptera: Culicidae) in Southern France,J Med Entomol,,,,2015,2010-present,November 20, 2015,26581402,10.1093/jme/tjv184,1364,English,,"MIVEGEC, UMR IRD224-CNRS5290-Universite de Montpellier, Institut de Recherche pour le Developpement, BP 64501, 34394 Montpellier, France (davidroiz@gmail.com; sduperier@yahoo.fr; philippe.bousses@ird.fr; dfontenille@pasteur-kh.org; frederic.simard@ird.fr; christophe.paupy@ird.fr), davidroiz@gmail.com., MIVEGEC, UMR IRD224-CNRS5290-Universite de Montpellier, Institut de Recherche pour le Developpement, BP 64501, 34394 Montpellier, France (davidroiz@gmail.com; sduperier@yahoo.fr; philippe.bousses@ird.fr; dfontenille@pasteur-kh.org; frederic.simard@ird.fr; christophe.paupy@ird.fr)., Laboratoire de Biometrie et Biologie Evolutive UMR5558-CNRS, Universite de Lyon, Universite Claude Bernard Lyon 1, Villeurbanne, France (marion.roussel1@gmail.com), and., MIVEGEC, UMR IRD224-CNRS5290-Universite de Montpellier, Institut de Recherche pour le Developpement, BP 64501, 34394 Montpellier, France (davidroiz@gmail.com; sduperier@yahoo.fr; philippe.bousses@ird.fr; dfontenille@pasteur-kh.org; frederic.simard@ird.fr; christophe.paupy@ird.fr), Institut Pasteur du Cambodge, Phnom Penh, Cambodia.",,,,,"Aedes albopictus, BG-Sentinel, attractant, mosquito trapping, trap","Targeted trapping of mosquito disease vectors plays an important role in the surveillance and control of mosquito-borne diseases. The Asian tiger mosquito, Aedes albopictus (Skuse), is an invasive species, which is spreading throughout the world, and is a potential vector of 24 arboviruses, particularly efficient in the transmission of chikungunya, dengue, and zika viruses. Using a 4 x 4 Latin square design, we assessed the efficacy of the new BG-Sentinel 2 mosquito trap using the attractants BG-lure and (R)-1-octen-3-ol cartridge, alone or in combination, and with and without carbon dioxide, for the field collection of Ae. albopictus mosquitoes.We found a synergistic effect of attractant and carbon dioxide that significantly increased twofold to fivefold the capture rate of Ae. albopictus. In combination with carbon dioxide, BG-lure cartridge is more effective than (R)-1-octen-3-ol in attracting females, while a combination of both attractants and carbon dioxide is the most effective for capturing males. In the absence of carbon dioxide, BG-lure cartridge alone did not increase the capture of males or females when compared with an unbaited trap. However, the synergistic effect of carbon dioxide and BG-lure makes this the most efficient combination in attracting Ae. albopictus.",Pubmed,March 31, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Original research,No,Yes,217,Environmental and vector research,Other ecological
218,"Choumet, Rev Sci Tech, 2015",Choumet,"Choumet, V.; Despres, P.",Dengue and other flavivirus infections,Rev Sci Tech,34,2,"473-8, 467-72",2015,2010-present,November 26, 2015,26601449,,1362,English,http://www.ncbi.nlm.nih.gov/pubmed/26601449,,,,,,Aedes/physiology/*virology; Animals; Dengue/prevention & control/*virology; Flavivirus Infections/prevention & control/*virology; Global Health; Humans; Insect Vectors; Viral Vaccines; Zika Virus; Zika Virus Infection/prevention & control/virology,"Flaviviruses are responsible for yellow fever, Zika fever and dengue, all of which are major human diseases found in tropical regions of the globe. They are zoonoses with a transmission cycle that involves primates as reservoirs and mosquitoes of the genus Aedes as vectors. The recent upsurge of urban epidemics of yellow fever, Zika fever and dengue has involved human-to-human transmission with mosquitoes as the vector. This paper is primarily concerned with dengue, which has become the pre-eminent arbovirosis in terms of public health.",Pubmed,March 31, 2016,Yes,,No,"Zika, not relevant to causality framework",Scientific (journal) article,Yes,Review,No,Yes,218,Clinical/epidemiological research,Epidemiological/clinical review
219,"Zwizwai, Lancet Infect Dis, 2015",Zwizwai,"Zwizwai, R.",Infectious disease surveillance update,Lancet Infect Dis,15,12,1385,2015,2010-present,November 27, 2015,26607128,10.1016/S1473-3099(15)00421-1,1361,English,http://www.ncbi.nlm.nih.gov/pubmed/26607128,,,,,,"Colombia/epidemiology; Coronavirus Infections/*epidemiology; Dysentery, Bacillary/*epidemiology; Epidemiological Monitoring; Humans; Leishmaniasis, Visceral/*epidemiology; Saudi Arabia/epidemiology; South Sudan/epidemiology; United States/epidemiology; Zika Virus Infection/*epidemiology",,Pubmed,March 31, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",News item or lay press,,,No,Yes,219,,
220,"Marcondes, Rev Soc Bras Med Trop, 2015",Marcondes,"Marcondes, C. B., Ximenes, M. F.",Zika virus in Brazil and the danger of infestation by Aedes (Stegomyia) mosquitoes,Rev Soc Bras Med Trop,,,,2015,2010-present,December 23, 2015,26689277,10.1590/0037-8682-0220-2015,1354,English,,"Departamento de Microbiologia, Imunologia e Parasitologia, Centro de Ciencias Biologicas, Universidade Federal de Santa Catarina, Florianopolis, Santa Catarina, Brazil., Departamento de Microbiologia e Parasitologia, Centro de Biociencias, Universidade Federal do Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil.",,,,,,"Zika virus, already widely distributed in Africa and Asia, was recently reported in two Northeastern Brazilian: State of Bahia and State of Rio Grande do Norte, and one Southeastern: State of Sao Paulo. This finding adds a potentially noxious virus to a list of several other viruses that are widely transmitted by Aedes (Stegomyia) aegypti and Aedes (Stegomyia) albopictus in Brazil. The pathology and epidemiology, including the distribution and vectors associated with Zika virus, are reviewed. This review is focused on viruses transmitted by Aedes (Stegomyia) mosquitoes, including dengue, Chikungunya, Zika, Mayaro, and yellow fever virus, to emphasize the risks of occurrence for these arboviruses in Brazil and neighboring countries. Other species of Aedes (Stegomyia) are discussed, emphasizing their involvement in arbovirus transmission and the possibility of adaptation to environments modified by human activities and introduction in Brazil.",Pubmed,March 31, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Review,No,Yes,220,Environmental and vector research,Ecological/Vector review
221,"Dyer, BMJ, 2015",Dyer,"Dyer, O.",Zika virus spreads across Americas as concerns mount over birth defects,BMJ,351,,h6983,2015,2010-present,December 25, 2015,26698165,10.1136/bmj.h6983,1352,English,,Montreal.,,,,,"Congenital Abnormalities/*epidemiology/etiology, Disease Outbreaks/*statistics & numerical data, Female, Humans, Infant, Newborn, Male, Pregnancy, United States/epidemiology, *Zika Virus, *Zika Virus Infection/complications/epidemiology/virology",,Pubmed,March 31, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",News item or lay press,,,No,Yes,221,,
222,"Tappe, Med Microbiol Immunol, 2015",Tappe,"Tappe, D.; Perez-Giron, J. V.; Zammarchi, L.; Rissland, J.; Ferreira, D. F.; Jaenisch, T.; Gomez-Medina, S.; Gunther, S.; Bartoloni, A.; Munoz-Fontela, C.; Schmidt-Chanasit, J.",Cytokine kinetics of Zika virus-infected patients from acute to reconvalescent phase,Med Microbiol Immunol,,,,2015,2010-present,December 26, 2015,26702627,10.1007/s00430-015-0445-7,1351,English,http://www.ncbi.nlm.nih.gov/pubmed/26702627,"WHO Collaborating Centre for Arbovirus and Haemorrhagic Fever Reference and Research, Bernhard Nocht Institute for Tropical Medicine, Bernhard-Nocht-Str. 74, 20359, Hamburg, Germany. tappe@bnitm.de.; German Centre for Infection Research (DZIF), Partner Site Hamburg-Luebeck-Borstel, Hamburg, Germany. tappe@bnitm.de.; Heinrich Pette Institute, Leibniz Institute for Experimental Virology, Hamburg, Germany.; Clinica Malattie Infettive, Dipartimento di Medicina Sperimentale e Clinica, Universita Degli Studi di Firenze, Florence, Italy.; Institute of Virology, Saarland University Medical Center, Homburg/Saar, Germany.; Institute of Microbiology, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.; Section Clinical Tropical Medicine, Department for Infectious Diseases, Heidelberg University Hospital, Heidelberg, Germany.; WHO Collaborating Centre for Arbovirus and Haemorrhagic Fever Reference and Research, Bernhard Nocht Institute for Tropical Medicine, Bernhard-Nocht-Str. 74, 20359, Hamburg, Germany.; German Centre for Infection Research (DZIF), Partner Site Hamburg-Luebeck-Borstel, Hamburg, Germany.",Germany,Europe,Germany,Not reported/unknown,Arbovirus; Cytokine; Flavivirus; Outbreak; Zika fever; Zika virus,"Zika virus is an emerging mosquito-borne flavivirus currently causing large epidemics in the Pacific Ocean region and Brazil. Clinically, Zika fever resembles dengue fever, but is less severe. Whereas the clinical syndrome and laboratory diagnostic procedures have been described, little attention was paid to the immunology of the disease and its possible use for clinical follow-up of patients. Here, we investigate the role of cytokines in the pathogenesis of Zika fever in travelers returning from Asia, the Pacific, and Brazil. Polyfunctional T cell activation (Th1, Th2, Th9, and Th17 response) was seen during the acute phase characterized by respective cytokine level increases, followed by a decrease in the reconvalescent phase.",Pubmed,March 31, 2016,Yes,,No,"Zika, indirect evidence or other topic",Scientific (journal) article,Yes,Original research,No,Yes,222,Clinical/epidemiological research,Case series
223,"Valero, Invest Clin, 2015",Valero,"Valero, Nereida",[Zika virus: Another emerging arbovirus in Venezuela?],Invest Clin,56,3,241-2,2015,2010-present,December 30, 2015,26710538,,1349,Spanish,,,,,,,"Aedes/*virology, Animals, Humans, Incidence, Population Surveillance, Venezuela/epidemiology, *Zika Virus, Zika Virus Infection/*epidemiology/prevention & control","Current health conditions of Venezuela, together with the tropical proliferation of different types of Aedes (aegypti and albopictus), suggest the arrival to this country of ZIKA virus (ZIKV). The Pan American Health Organization urges Latin American countries to take measures to prevent the ZIKV entry and advises that these measures must be designed to detect the introduction of ZIKV in an area, track its spread and actively monitor the disease. In Venezuela and other Latin-American countries, where endemicity is high for other arboviruses such as dengue arid chikungunya, health authorities should strengthen their surveillance systems to detect early and timely introduction of ZIKV ap.d refine diagnostic methods to confirm the infection rate; however, the high incidence of cases due those viral agents reflects weakened and poorly timed insensitive monitoring systems, as well as, poor vector control measures, arising the questions: will this arbovirus pop in our country, will it set as the other as edemicepidemic and lead to alter their clinical behavior and severity of the disease?",Pubmed,March 31, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,223,,
224,"Valeyrie-Allanore, Ann Dermatol Venereol, 2015",Valeyrie-Allanore,"Valeyrie-Allanore, L.",[What's new in clinical dermatology?],Ann Dermatol Venereol,142 Suppl 3,,S1-7,2015,2010-present,January 23, 2016,26792410,10.1016/s0151-9638(16)30001-1,1333,French,,"Service de dermatologie, centre de reference des maladies bulleuses immunologiques et toxiques, AP-HP, hopital Henri-Mondor, 51, avenue du Marechal-de-Lattre-de-Tassigny, 94000 Creteil Cedex ; universite Paris-Est Creteil, Creteil, France. Electronic address: laurence.allanore@hmn.aphp.fr.",,,,,"Agents infectieux emergeants, Burden, Drug adverse reaction, Emerging infectious agents, Fardeau, Hidradenitis suppurativa, IgG4-related disease, Maladie de Verneuil, Maladie a IgG4, Neuropathie des petites fibres, Pemphigoid, Pemphigoide, Psoriasis, Small-fiber neuropathy, Toxidermies","Significant advances have been performed in cutaneous adverse reactions leading to primary prevention strategy and implication of new signaling pathways. Histological features of DRESS and methotrexate toxicity are detailed. New emerging infectious agents are reported including Zika Virus, an arbovirus which can be confused with dengue or chikungunya, a new cowpox virus transmitted by domestic cat leading to lymphadenitis, Spirurina type X larva transmitted in Japan by eating raw squid or fish. Malignancies in pemphigus and pemphigoid are emphasized. Expert recommandations are developped on definitions, diagnosis and disease activity of mucous membrane pemphigoid, bubllous pemphigoid and pemphigus. Psoriasis and cardiometabolic association are discussed. This risk association appears higher in hidradenitis suppurativa, which seems more frequent in patients of African ancestry. IgG4-related disease is an immune mediated entity characterized by fibroinflammatory lesions often misdiagnosed. Pruritus, heat sensations, numbness could be recognized as a small-fiber neuropathy symptoms. Burden impact in common dermatosis is demonstrated and should be integrated in our daily practice.",Pubmed,March 31, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,224,,
225,"Pinto Junior, Acta Med Port, 2015",Pinto Junior,"Pinto Junior, V. L., Luz, K., Parreira, R., Ferrinho, P.",[Zika Virus: A Review to Clinicians],Acta Med Port,28,6,760-5,2015,2010-present,February 6, 2016,26849762,,1304,Portuguese,,"Departamento de Epidemiologia e Vigil'ncia em Saude. Fiocruz Brasilia. Brasilia. Brasil. Global Health and Tropical Medicine. Instituto de Higiene e Medicina Tropical. Universidade NOVA de Lisboa. Lisboa. Portugal., Departamento de Doencas Infecciosas. Instituto de Medicina Tropical do Rio Grande do Norte. Universidade Federal do Rio Grande do Norte. Natal. Brasil., Global Health and Tropical Medicine. Instituto de Higiene e Medicina Tropical. Universidade NOVA de Lisboa. Lisboa. Portugal.",,,,,,"Zika virus is a flavivirus related to Dengue virus, yellow fever virus and West Nile virus. It is considered an emerging arbovirus transmitted by mosquitos of the genus Aedes. Its first description took place in 1947 in the Zika Forest in Uganda, isolated on Rhesus monkey used as bait to study the yellow fever virus. Sporadic cases have been detected in African countries and at the end of the 70's in Indonesia. In 2007, epidemics were described in Micronesia and other islands in the Pacific Ocean and more recently in Brazil. Clinical picture is characterized as a 'dengue-like' syndrome, with abrupt onset of fever and an early onset evanescent rash, often pruritic. Occasionally the disease has been associated with Guillain-Barre syndrome. Nevertheless, until now deaths and complications caused by the disease were not reported. The diagnosis can be performed by PCR or by IgG and IgM antibodies detection. The rapid spread of the virus and its epidemic potential are especially problematic in countries where there are the circulation of other arboviruses whichimposes difficulties in the differential diagnosis and healthcare burden. Control measures are the same recommended for dengue and chikungunya which are based in health education and vector control., Publisher: Abstract available from the publisher., por",Pubmed,March 31, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Yes,Review,No,Yes,225,Clinical/epidemiological research,Epidemiological/clinical review
226,"Brito, Acta Med Port, 2015",Brito,"Brito, C.",Zika Virus: A New Chapter in the History of Medicine,Acta Med Port,28,6,679-80,2015,2010-present,February 6, 2016,26849748,,1305,English,,Professor Adjunto. Universidade Federal de Pernambuco. Recife. Brasil.,,,,,,,Pubmed,March 31, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,226,,
227,"von Eije, Ned Tijdschr Geneeskd, 2015",von Eije,"von Eije, K. J.; Schinkel, J.; van den Kerkhof, J. H.; Schreuder, I.; de Jong, M. D.; Grobusch, M. P.; Goorhuis, A.",[Imported Zika virus infection in the Netherlands],Ned Tijdschr Geneeskd,160,0,D153,2015,2010-present,February 26, 2016,26906886,,1250,Other,http://www.ncbi.nlm.nih.gov/pubmed/26906886,"Academisch Medisch Centrum, Amsterdam.",,,,,,"Since mid-2015, a rapidly expanding outbreak of Zika virus infection is spreading across Latin America and the Caribbean. Although Zika virus infection usually causes only mild disease, the World Health Organization has declared the epidemiological association with the occurrence of congenital microcephaly and neurological complications a 'Public Health Emergency of International Concern' and urged the international community to mount a coordinated international response aimed to protect people at risk, especially pregnant women. In December 2015, the first case of imported Zika virus infection in the Netherlands was diagnosed in a returned traveler from Surinam. To date, more than 20 cases have been reported in The Netherlands, all imported from Surinam. We describe the epidemiology, clinical aspects, diagnostic challenges and the existing evidence to date that link Zika virus infection to complications.",Pubmed,March 31, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Original research,No,Yes,227,Clinical/epidemiological research,Case series
228,"Galindo-Fraga, Rev Invest Clin, 2015",Galindo-Fraga,"Galindo-Fraga, A., Ochoa-Hein, E., Sifuentes-Osornio, J., Ruiz-Palacios, G.",Zika Virus: A New Epidemic on Our Doorstep,Rev Invest Clin,67,6,329-32,2015,2010-present,March 8, 2016,26950736,,1178,English,,"Department of Hospital Epidemiology and Health Care Quality Control, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico., Department of Medicine, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico., Commissioner, Mexican National Institutes of Health, Mexico City, Mexico.",,,,,,"Zika virus, a flavivirus transmitted to humans by mosquitoes of the genus Aedes, was first described in humans as isolated cases in Africa. Outbreaks have been reported outside that region since 2007, followed by its gradual introduction to different geographical areas. In 2015, Zika virus was detected in Brazil, from where it is rapidly expanding in the continent; the first case in Mexico was detected in October 2015. Initially deemed as a cause of mild illness, confirmation of microcephaly cases associated with this infection in Brazil have resulted in the World Health Organization declaration of Zika virus infection as a Public Health Emergency of International Concern. The US Centers for Disease Control and Prevention issued travel alerts for countries with declared cases. The vector is widely distributed in Mexico and control measures are the most effective means for prevention, not only of Zika virus, but also dengue and chikungunya.",Pubmed,March 31, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,228,,
229,"Dhimal, J Nepal Health Res Counc, 2015",Dhimal,"Dhimal, M., Gautam, I., Baral, G., Pandey, B., Karki, K. B.",Zika Virus: Yet Another Emerging Threat to Nepal,J Nepal Health Res Counc,13,31,248-51,2015,2010-present,March 24, 2016,27005721,,1092,English,,"Nepal Health Research Council, Ramshah Path, Kathmandu, Nepal., Tribhuvan University, Natural History Museum, Swayambhu, Nepal., Paropakar Maternity and Women's Hospital, Thapathali, Nepal., Leprosy Control Division, Department of Health Services, Ministry of Health, Kathmandu, Nepal.",,,,,,"Zika virus (ZIKV) is a flavivirus with single stranded RNA related to yellow fever, dengue, West Nile, and Japanese encephalitis viruses and is transmitted by Aedes mosquitoes primarily by Aedes aegipti which is widely distributed in Nepal. ZIKV was first identified incidentally in Rhesus monkey in Uganda in 1947 and human infection in 1952; and by now outbreaks of ZIKV disease have been recorded in Africa, the Americas, Asia and the Pacific. The World Health Organization (WHO) has recently declared the ZIKV an international public health emergency. The aim of this paper is to briefly summarize origin, signs, symptoms, transmission, diagnosis, preventions and management of ZIKV and possible threat to Nepal in light of endemicity of other arbovirus infections and common mosquito vector species in Nepal. Keyword: Aedes aegypti; aedes albopictus; zika virus; microcephaly; birth defect; Nepal.",Pubmed,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,229,,
230,"Xu, F1000Res, 2015",Xu,"Xu, P.; Zhu, F.; Buss, G. K.; Leal, W. S.",1-Octen-3-ol - the attractant that repels,F1000Res,4,,156,2015,2010-present,,26543554,10.12688/f1000research.6646.1,1841,,http://www.ncbi.nlm.nih.gov/pubmed/26543554,"Department of Molecular and Cellular Biology, University of California-Davis, Davis, CA, 95616, USA.",,,,,CquiOR114b; CquiOR118b; Culex quinquefasciatus; antennae; chiral discrimination; maxillary palps; odorant receptors; repellency assay,"Since the discovery in the early 1980s that 1-octen-3-ol, isolated from oxen breath, attracts tsetse fly, there has been growing interest in exploring the use of this semiochemical as a possible generic lure for trapping host-seeking mosquitoes. Intriguingly, traps baited with 1-octen-3-ol captured significantly more females of the malaria mosquito, Anopheles gambiae, and the yellow fever mosquito, Aedes aegypti, than control traps, but failed to attract the southern house mosquito, Culex quinquefasciatus. Additionally, it has been demonstrated that this attractant is detected with enantioselective odorant receptors (ORs) expressed only in maxillary palps. On the basis of indoor behavioral assays it has even been suggested that 1-octen-3-ol might be a repellent to the southern house mosquito. Our approach was two-prong, i.e., to isolate 1-octen-3-ol-sensitive ORs expressed in maxillary palps and antennae of southern house female mosquito, and test the hypothesis that this semiochemical is a repellent. An OR with high transcript levels in maxillary palps, CquiOR118b, showed remarkable selectivity towards ( R)-1-octen-3-ol, whereas an OR expressed in antennae, CquiOR114b, showed higher preference for ( S)-1-octen-3-ol than its antipode. Repellency by a surface landing and feeding assay showed that not only racemic, but enantiopure ( R)- and ( S)-1-octen-3-ol are repellents at 1% dose thus suggesting the occurrence of other ( S)-1-octen-3-ol-sensitive OR(s). Female mosquitoes with ablated maxillary palps were repelled by 1-octen-3-ol, which implies that in addition to OR(s) in the maxillary palps, antennal OR(s) are essential for repellency activity.",F1000,March 31, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Original research,No,Yes,230,Basic and applied biomedical research,Other basic research
231,"Abd El Wahed, Trop Med Int Health, 2015",Abd El Wahed,"Abd El Wahed, A., Patel, P., Faye, O., Nentwich, O., Wende, A., Piepenburg, O., Sall, A., Weidmann, M.","Abstracts of the 9th European Congress on Tropical Medicine and International Health, 6-10 September 2015, Basel, Switzerland",Trop Med Int Health,20 Suppl 1,,1-441,2015,2010-present,,26333674,10.1111/tmi.12575,1592,English,http://www.ncbi.nlm.nih.gov/pubmed/26333674,"(Abd El Wahed) German Primate Center (DPZ), Berlin, Germany (Abd El Wahed) Georg-August University, Goettingen, Germany (Patel) Robert Koch Institute, Berlin, Germany (Faye, Sall) Pasteur Institute, Dakar, Senegal (Nentwich, Piepenburg) TwistDx Ltd., Cambridge, United Kingdom (Wende) System Solutions, Qiagen GmbH, Hilden, Germany (Weidmann) University of Stirling, Stirling, United Kingdom, A. Abd El Wahed, German Primate Center (DPZ), Berlin, Germany",,,,,"Ebolavirus, European, tropical medicine, public health, laboratory, Ebola hemorrhagic fever, reverse transcription, Guinea, Plasmodium falciparum (HB3), real time polymerase chain reaction, laboratory test, Sierra Leone, laboratory diagnosis, Crimean Congo hemorrhagic fever, yellow fever, human, lysis, turnaround time, tube, gene amplification, assay, plasma, virus, Rift Valley fever, chikungunya, dengue, Plasmodium falciparum, Liberia, RNA extraction, rna, recombinase, antigen, dna","INTRODUCTION The current outbreak of Ebola has killed over 10 000 people in Guinea, Sierra Leone and Liberia. Early identification and isolation of the infected Ebola cases are the most important control measures. Detection of the Ebola virus by using the rapid antigen lateral flow tests is an easy to be applied at the point-of-care. Nevertheless, the results must be confirmed by additional laboratory tests. Laboratory diagnosis mainly depends on Ebola RNA detection by reverse transcription real-time polymerase chain reaction (RT-PCR), which is available in central laboratories and has a turnaround time of more than 3 h. For decentralized low resource settings, there is a need for a simple molecular point-of-need test. MATERIALS AND METHODS In this study, a mobile suitcase laboratory (62x 49x 30 cm) containing all reagents and equipment for the detection of Ebola RNA was developed. Moreover, it was operated by a solar power battery. All reagents were cold-chain independent in order to ease the use at poor resource settings. RNA extraction was performed by a magnetic bead based method, in which a simple fast lysis protocol was applied. In one reaction tube, the reverse transcription step as well as the DNA amplification and detection by the recombinase polymerase amplification (RPA) assay was achieved. RESULTS Using spiked plasma samples, as few as 15 Ebola RNA copies were detected in less than 30 min, while samples containing Crimean-Congo-Hemorrhagic-Fever, Yellow Fever, Lassa, Marburg, Rift Valley Fever, Dengue, Chikungunya and Zika viruses and Plasmodium falciparum were negative. CONCLUSION The mobile suitcase laboratory is ideal for rapid sensitive and specific detection of Ebola virus especially at low resource settings. Currently, two mobile suitcase laboratories are being used in Guinea.",Embase,March 31, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Original research,No,Yes,231,Basic and applied biomedical research,Other basic research
232,"Aubry, Vox Sanguinis, 2015",Aubry,"Aubry, M. T. P., Richard, V., Green, J., Broult, J., Musso, D.",Amotosalen and ultraviolet a light inactivate zika virus in plasma,Vox Sanguinis,109,,189-190,2015,2010-present,,71948077,,1619,English,http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emed13&AN=71948077,"(Aubry, Richard, Musso) Institut Louis Malarde, Papeete, French Polynesia (Green) Cerus Corporation, California, United States (Broult) Hopital du Taaone, Pirae, French Polynesia, M.T.P. Aubry, Institut Louis Malarde, Papeete, French Polynesia",,,,,"society, blood transfusion, virus, plasma, ultraviolet A radiation, infection, Arbovirus, reverse transcription polymerase chain reaction, virus culture, pathogenesis, blood donor, transfusion, French Polynesia, Dengue virus, United States, chikungunya, neurological complication, diseases, blood, Vero cell line, procedures, cell culture, tissue culture, mosquito, immunofluorescence, prevention, titrimetry, questionnaire, AGMK cell line, donor, plasma transfusion, illumination, immunofluorescence test, amotosalen, rna, virus RNA, fresh frozen plasma, nucleic acid, immunoglobulin G","Background: Zika virus (ZIKV) is an arthropod-borne virus (arbovirus) transmitted by the bite of infected mosquitoes. Symptoms of ZIKV infections are typically mild, but severe neurologic complications can occur. The potential for ZIKV transmission through blood transfusion was demonstrated during the largest ZIKV outbreak that occurred in French Polynesia from October 2013 to April 2014: 2.8% of the blood donors, asymptomatic at the time of blood donation, were found positive using ZIKV-specific reverse transcription PCR (RT-PCR). Prevention of transfusion-transmitted ZIKV infections is challenging because most of the cases are asymptomatic, and are not detected during medical questionnaire, and nucleic acid testing for ZIKV is not routinely available. Pathogen inactivation of blood products is a proactive strategy that provides the potential to reduce transfusion-transmitted diseases. Inactivation of arboviruses by amotosalen and ultraviolet A (UVA) illumination was previously demonstrated for chikungunya, West Nile (WNV) and dengue viruses (DENV). We report here the efficacy of this strategy for ZIKV inactivation in plasma. Aims: According to the recommendations for evaluation of pathogen reduction efficacy, we performed a spiking experiment of plasma units with ZIKV in order to compare the viral titers and viral RNA loads before and after inactivation. Methods: Plasma units were collected in California (USA) from DENV and WNV immunoglobulin G negative donors. ZIKV was propagated on African green monkey kidney cells (VERO) and concentrated. Four plasma units were spiked with ZIKV before transfer into an INTERCEPT disposable kit (INT3102B, Cerus Corporation). Three units were inactivated with amotosalen and 3 J/cm<sup>2</sup> UVA light for ~6 min, the fourth one was not and was the positive control. Detection of replicative ZIKV and viral titration was performed by inoculating preand post-inactivated plasma unit samples on VERO cells. Five serial passages of plasma unit samples were performed in order to amplify any replicative virus. Infected cells were detected by an indirect immunofluorescence (IF) assay, and viral titers were expressed in 50% tissue culture infectious dose (TCID<inf>50</inf>/mL). ZIKV RNA loads were measured after each passage on cell culture. RNA quantitation was performed by RT-PCR and expressed in log<inf>10</inf> copies/ml. Results: Before inactivation, the mean viral titer was 6.57 log<inf>10</inf> TCID<inf>50</inf>/ml. The culture of pre-inactivated sample showed the presence of replicative viruses during the five serial passages. In contrast, no replicative virus was detected in post-inactivated plasma units, even after five passages (Table). Before inactivation, the mean viral RNA load was 10.25 log<inf>10</inf> copies/ml. After inactivation, the mean viral RNA load was 9.51 log<inf>10</inf> copies/ml, and decreased to 3.86 log<inf>10</inf> copies/ml after the first passage. From the second and up to the fifth passage on VERO cells, the viral RNA remained undetectable indicating the absence of replicative virus. [TABLE PRESENTED] Conclusions: Amotosalen combined with UVA light inactivated ZIKV in fresh frozen plasma (6.57 log<inf>10</inf> by infectivity, and 10.25 log<inf>10</inf> by RT-PCR), and therefore may be used to prevent plasma transfusion-transmitted ZIKV infections. This procedure is of particular interest in areas, as French Polynesia, in which several arboviruses are co-circulating.",Embase,March 31, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Original research,No,Yes,232,Basic and applied biomedical research,Other basic research
233,"Enserink, Science, 2015",Enserink,"Enserink, M.","An obscure mosquito-borne disease goes global: After racing through Oceania last year, the Zika virus is now spreading in the Americas",Science,350,6264,1012-1013,2015,2010-present,,2015549674,,1585,English,"http://www.sciencemag.org/content/350/6264/1012.full.pdf, http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emed13&AN=2015549674",M. Enserink,,,,,"epidemic, human, nonhuman, note, Pacific islands, priority journal, South and Central America, urban area, virus, virus infection, virus transmission, Western Hemisphere, zika virus, Zika virus infection",,Embase,March 31, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",News item or lay press,,,No,Yes,233,,
234,"Phi Hung, F1000Res, 2015",Phi Hung,"Phi Hung, L.; Diem Nghi, T.; Hoang Anh, N.; Van Hieu, M.; Thien Luan, N.; Phuoc Long, N.; Trong Thach, T.",Case Report: Postpartum hemorrhage associated with Dengue with warning signs in a term pregnancy and delivery,F1000Res,4,,1483,2015,2010-present,,26925224,10.12688/f1000research.7589.1,1839,,http://www.ncbi.nlm.nih.gov/pubmed/26925224,"University of Medicine and Pharmacy, Ho Chi Minh, Vietnam.; School of Medicine, Vietnam National University, Ho Chi Minh, Vietnam.; University of Medicine and Pharmacy, Ho Chi Minh, Vietnam; Hung Vuong Hospital, Ho Chi Minh, Vietnam.",,,,,Dengue with warning signs; polyhydramnios; postpartum hemorrhage; pregnancy; uterine atony,"BACKGROUND: Dengue infection during peripartum period, although rare in endemic regions, has challenged clinicians regarding its management, especially if a parturient woman experiences postpartum hemorrhage due to a classical risk factor of maternal bleeding. CASE: A full-term pregnant Vietnamese woman was diagnosed with polyhydramnios and Dengue with warning signs (DWS). She was administered platelet transfusion prior to delivery and then gave birth to a healthy newborn. After active management of the third stage of labor, the patient suffered a postpartum hemorrhage which was caused by uterine atony and accompanied with thrombocytopenia. Therefore, we decided to administer uterotonic drugs and additionally transfuse platelets. CONCLUSION: We describe a case of postpartum hemorrhage caused by uterine atony and coinciding with Dengue infection during delivery period, which is a rare clinical entity. With timely detection and management, the patient was finally discharged without complications.",F1000,March 31, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Original research,No,Yes,234,Clinical/epidemiological research,Case report
235,"Dusfour, PLoS Negl Trop Dis, 2015",Dusfour,"Dusfour, I.; Zorrilla, P.; Guidez, A.; Issaly, J.; Girod, R.; Guillaumot, L.; Robello, C.; Strode, C.",Deltamethrin Resistance Mechanisms in Aedes aegypti Populations from Three French Overseas Territories Worldwide,PLoS Negl Trop Dis,9,11,e0004226,2015,2010-present,,26588076,10.1371/journal.pntd.0004226,1893,,http://www.ncbi.nlm.nih.gov/pubmed/26588076,"Institut Pasteur de la Guyane, Unite d'Entomologie Medicale, Cayenne, French Guiana, France.; Unidad de Biologia Molecular, Institut Pasteur de Montevideo and Dept. of Biochemistry, School of Medicina, Montevideo, Uruguay.; Institut Pasteur de Nouvelle Caledonie, Unite de Recherche et d'Expertise en Entomologie Medicale, Noumea, New Caledonia.; Biology Department, Edge Hill University, Ormskirk, Lancashire, United Kingdom.",,,,,,"BACKGROUND: Aedes aegypti is a cosmopolite mosquito, vector of arboviruses. The worldwide studies of its insecticide resistance have demonstrated a strong loss of susceptibility to pyrethroids, the major class of insecticide used for vector control. French overseas territories such as French Guiana (South America), Guadeloupe islands (Lesser Antilles) as well as New Caledonia (Pacific Ocean), have encountered such resistance. METHODOLOGY/PRINCIPAL FINDINGS: We initiated a research program on the pyrethroid resistance in French Guiana, Guadeloupe and New Caledonia. Aedes aegypti populations were tested for their deltamethrin resistance level then screened by an improved microarray developed to specifically study metabolic resistance mechanisms. Cytochrome P450 genes were implicated in conferring resistance. CYP6BB2, CYP6M11, CYP6N12, CYP9J9, CYP9J10 and CCE3 genes were upregulated in the resistant populations and were common to other populations at a regional scale. The implication of these genes in resistance phenomenon is therefore strongly suggested. Other genes from detoxification pathways were also differentially regulated. Screening for target site mutations on the voltage-gated sodium channel gene demonstrated the presence of I1016 and C1534. CONCLUSION /SIGNIFICANCE: This study highlighted the presence of a common set of differentially up-regulated detoxifying genes, mainly cytochrome P450 genes in all three populations. GUA and GUY populations shared a higher number of those genes compared to CAL. Two kdr mutations well known to be associated to pyrethroid resistance were also detected in those two populations but not in CAL. Different selective pressures and genetic backgrounds can explain such differences. These results are also compared with those obtained from other parts of the world and are discussed in the context of integrative research on vector competence.",PLoS,March 31, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Original research,No,Yes,235,Environmental and vector research,Ecological/animal cross-sectional
236,"Rodríguez-Morales, Archivos de Medicina, 2015",Rodríguez-Morales,"Rodríguez-Morales, A. J.",Dengue and chikungunya were not enough: Now also Zika arrived,Archivos de Medicina,11,2,,2015,2010-present,,2015135725,http://dx.doi.org/10.3823/1245,1608,English,"http://archivosdemedicina.com/medicina-de-familia/no-era-suficiente-con-denguey-chikungunya-lleg-tambinzika.pdf, http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emed13&AN=2015135725","(Rodriguez-Morales) Universidad Tecnologica de Pereira, Pereira, Risaralda, Colombia, A.J. Rodriguez-Morales, Universidad Tecnologica de Pereira, Pereira, Risaralda, Colombia",,,,,"chikungunya, dengue, editorial, virus infection, zika fever",,Embase,March 31, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,236,,
237,"Wilson, Curr Infect Dis Rep, 2015",Wilson,"Wilson, M. E.; Chen, L. H.",Dengue: update on epidemiology,Curr Infect Dis Rep,17,1,457,2015,2010-present,,25475383,10.1007/s11908-014-0457-2,1598,English,http://www.ncbi.nlm.nih.gov/pubmed/25475383,"University of California, San Francisco, CA, USA, mewilson@hsph.harvard.edu.",,,,,"Aedes aegypti, Aedes albopictus, Air travel, Chikungunya, Climate change, Co-infection, Dengue, Disease burden, Emerging infection, Epidemic, Epidemiology, Forecasting outbreaks, Hemorrhagic fever, Mapping, Models, Mosquito, Seroptyes, Surveillance, Transmission, Travel, Vector, Zika virus, Africa, Asia, blood transfusion, dengue/ep [Epidemiology], disease severity, epidemiological monitoring, Europe, Federated States of Micronesia, French Polynesia, geographic mapping, human, infection control, Middle East, needlestick injury, North America, organ transplantation, Pacific islands, review, risk, serotype, species endemicity, tropics, virus load, virus transmission, Western Hemisphere","The epidemiology of dengue fever has undergone major shifts in recent decades. The global distribution has expanded to include more geographic areas. The intensity of transmission and the severity of infections have increased in areas where infection was already endemic. Multiple studies provide a clearer picture of the epidemiology and allow mapping of its distribution and change over time. Despite major efforts to control transmission, competent vectors now infest most tropical and subtropical regions; Aedes albopictus, also a competent vector, is able to survive in temperate areas, placing parts of Europe and North America at risk for local transmission. Many research teams in dengue-endemic areas are working to identify key local weather, vector, and other variables that would allow prediction of a likely epidemic early enough to permit interventions to avert it or blunt its impact.",F1000,March 31, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,237,,
238,"Nhan, Virologie, 2015",Nhan,"Nhan, T. X., Musso, D.",Emergence of the Zika virus,Virologie,19,5,225-235,2015,2010-present,,2015495415,,1590,English,"http://www.jle.com/en/revues/vir/e-docs/vaccin_chimere_anti_ebola_chez_lhomme_les_raisons_dun_espoir_305664/article.phtml?tab=download&pj_key=doc_attach_29055, http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emed13&AN=2015495415","(Nhan, Musso) Laboratoire d'Analyses de Biologie Medicale, Institut Louis-Malarde, PO BOX 30, Papeete, Tahiti 98713, French Polynesia (Musso) Pole de Recherche et de Veille sur les Maladies Infectieuses Emergentes, Institut Louis-Malarde, Tahiti, French Polynesia",,,,,"Aedes aegypti, Aedes albopictus, Arbovirus, clinical feature, cross reaction, epidemic, fever, Flavivirus, Flavivirus infection/ep [Epidemiology], French Polynesia, human, laboratory diagnosis, neurological complication, nonhuman, review, serodiagnosis, zika virus, Zika virus infection/ep [Epidemiology], virus RNA","Zika virus (ZIKV) is anarthropod-borne virus (arbovirus) of the family Flaviviridae, genus Flavivirus, transmitted by the bite of infected mosquitoes. ZIKV was first isolated from a non-human primate in 1947, ZIKV infections in humans were sporadic during 60 years before emerging in the Pacific in 2007 and 2013 and in Brazil in 2015. Due to a non-specific clinical presentation, Zika fever can be misdiagnosed with other arboviruses such as dengue and chikungunya. ZIKV infections were associated with mild illness before the large French Polynesia outbreak in 2013-2014 in which severe neurological complications were reported. Routine laboratory diagnosis of Zika fever relies on the detection of specific ZIKV RNA by PCR. Serological diagnosis is complicated due to cross reactivity with other flaviviruses. ZIKV adapted to an urban cycle involving humans and domestic mosquito vectors that are widely distributed, such as Aedes aegypti and Ae. albopictus. This adaptation highlights the potential for ZIKV to emerge in tropical, intertropical and also temperate areas.",Embase,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,238,,
239,"PAHO, Epidemiological update. Zika virus infection 31 March 2016, 2015",PAHO,PAHO,Epidemiological update. Zika virus infection 31 March 2016,,Epidemiological update. Zika virus infection 31 March 2016,,,2015,2010-present,,,,1854,,http://www.paho.org/hq/index.php?option=com_docman&task=doc_view&Itemid=270&gid=32636&lang=en,,United States,Americas,,Public/Government,,,PAHO,March 31, 2016,Yes,,Yes,,Surveillance report or data,,,No,Yes,239,Clinical/epidemiological research,Ecological study/outbreak report
240,"PAHO, Epidemiological update - 10 March 2016, 2015",PAHO,PAHO,Epidemiological update - 10 March 2016,,Epidemiological update - 10 March 2016,,,2015,2010-present,,,,1855,,http://www.paho.org/hq/index.php?option=com_docman&task=doc_view&Itemid=270&gid=32405&lang=en,,United States,Americas,,Public/Government,,,PAHO,March 31, 2016,Yes,,Yes,,Surveillance report or data,,,No,Yes,240,Clinical/epidemiological research,Ecological study/outbreak report
241,"PAHO, Epidemiological update. Zika virus infection -17 March 2016, 2015",PAHO,PAHO,Epidemiological update. Zika virus infection -17 March 2016,,Epidemiological update. Zika virus infection -17 March 2016,,,2015,2010-present,,,,1852,,http://www.paho.org/hq/index.php?option=com_docman&task=doc_view&Itemid=270&gid=30075&lang=en,,United States,Americas,,Public/Government,,,PAHO,March 31, 2016,Yes,,Yes,,Surveillance report or data,,,No,Yes,241,Clinical/epidemiological research,Case series
242,"ECDC, , 2015",ECDC,ECDC,"Epidemiological update. Complications potentially linked to the Zika virus outbreak, Brazil and French Polynesia - 27 November 2015",,,,,2015,2010-present,,,,1853,,,,Sweden,Europe,,Public/Government,,,ECDC,March 31, 2016,Yes,,No,"Zika, indirect evidence or other topic",Surveillance report or data,,,No,Yes,242,Clinical/epidemiological research,Ecological study/outbreak report
243,"ECDC, , 2015",ECDC,ECDC,Epidemiological update. Evolution of the Zika virus global outbreaks and complications potentially linked to the Zika virus outbreaks - 4 December 2015,,,,,2015,2010-present,,,,1882,,,,Sweden,Europe,,Public/Government,,,ECDC,March 31, 2016,Yes,,No,"Zika, indirect evidence or other topic",Surveillance report or data,,,No,Yes,243,Clinical/epidemiological research,Ecological study/outbreak report
244,"ECDC, , 2015",ECDC,ECDC,Epidemiological update. Outbreaks of Zika virus and complications potentially linked to the Zika virus infection - 18 December 2015,,,,,2015,2010-present,,,,1877,,,,Sweden,Europe,,Public/Government,,,ECDC,March 31, 2016,Yes,,No,"Zika, indirect evidence or other topic",Surveillance report or data,,,No,Yes,244,Clinical/epidemiological research,Ecological study/outbreak report
245,"PAHO, Epidemiological update. Zika virus infection -17 March 2016, 2015",PAHO,PAHO,Epidemiological update. Zika virus infection -17 March 2016,,Epidemiological update. Zika virus infection -17 March 2016,,,2015,2010-present,,,,1875,,http://www.paho.org/hq/index.php?option=com_docman&task=doc_view&Itemid=270&gid=32021&lang=en,,United States,Americas,,Public/Government,,,PAHO,March 31, 2016,Yes,,Yes,,Surveillance report or data,,,No,Yes,245,Clinical/epidemiological research,Case series
246,"[No authors listed], Lancet, 2015",[No authors listed],[No authors listed],Health security: the defining challenge of 2016,Lancet,386,10012,2445,2015,2010-present,,26738700,10.1016/S0140-6736(15)01285-4,1897,,http://www.ncbi.nlm.nih.gov/pubmed/26738700,,,,,,*Advisory Committees; Arbovirus Infections; Asthma; Dementia; *Global Health; HIV Infections; Humans; Hypertension; Periodicals as Topic; *Research,,Lancet,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,246,,
247,"Santana, Journal of Molecular Diagnostics, 2015",Santana,"Santana, R. F.; Petroni, R. C.; Dastoli, G. F.; Fusco, V.; Souza, J.; Oliveira, V. M.; Rosa, S.; Oliveira, T.; Muto, N.; Sitnik, R.; Mangueira, C.; Pinho, J.",Implementation of Molecular Assay for Chikungunya Virus Detection in a Private Hospital During an Outbreak in Brazil for the Differential Diagnosis of Other Current Arboviruses Infection,Journal of Molecular Diagnostics,17,6,793-793,2015,2010-present,,364000000000,,1586,English,<Go to ISI>://:000363830000181,"Hosp Israelita Albert Einstein, Sao Paulo, Brazil",,,,,"Arbovirus, virus detection, private hospital, assay, differential diagnosis, Chikungunya virus, infection, molecular pathology, Brazil, human, Dengue virus, diagnosis, patient, mosquito, diseases, virus, virus infection, Caribbean, Western Hemisphere, tropical disease, Indian, Alphavirus, fever, rash, arthralgia, dengue, physician, risk, Asia, Africa, genus, chikungunya, RNA virus, laboratory diagnosis, disease control, diagnostic test, blood sampling, laboratory, patient care, Switzerland, computer program, hospital, Puerto Rico, Colombia, Aedes, public health problem, adenosine phosphate, rna, nucleic acid, immunoglobulin, virus RNA",,Embase,March 31, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Original research,No,Yes,247,Basic and applied biomedical research,Other basic research
248,"Carvajal, Med Interna (Caracas), 2015",Carvajal,"Carvajal, Ana C; Peña, Saul O; Oletta L., José Félix",Infección por virus Zika (VZIK): arbovirosis emergente en las Américas / Zika virus infection (VZIK): emerging arboviruses in the Americas,Med Interna (Caracas),31,1,Aug 15,2015,2010-present,,,,1817,Spanish,http://svmi.web.ve/wh/revista/V31_N1.pdf,,,,,,,"A new disease threatens the Americas, it is an infection caused by the Zika (VZIK) virus, which belongs to the Flaviviridae family, genus flavivirus. The VZIK was isolated in April 1947 in Uganda in the Zika forest and the the first infected human was in Nigeria in 1954. It is primarily transmitted by vectors of the genus Aedes, by vertical transmission, potentially through blood and only one case of sexual intercourse. It is considered an emerging disease; before 2007 reported cases were sporadic, two major outbreaks have been reported, one in 2012 in Yap, Micronesia and in the years 2013, 2014 and 2015 outbreaks had occurred in French Polynesia, Pascua Island (Chile), the Cook Islands and New Caledonia. Except for the VZIK outbreak at the Pascua Island in 2014, this disease was completely unknown in the Americas. Recently an outbreak has been reported in northern Brazil, because transmitters vectors, Aedes aegypti and A. albopictus, are widely distributed in the region, and outbreaks of greater magnitude are expected in a short period of time. The disease is similar to Dengue and Chikungunya, is characterized by myalgia, headache and hands and feet arthralgiae, non purulent, hemorrhagic and neurological complications are rare. It is believed that most of the cases are asymptomatic and until now no deaths have been reported. The recommended method for diagnosis is the real-time PCR of the first 3-5 days during viremia; the IgM and IgG serology have crossed reaction with other flaviviruses as dengue. Ministries of Health must activate their 'monitoring systems' for early detection of virus introducion and alert health professionals and general population about this emerging disease. The Americas could be affected by three diseases with similar clinical spectrum of dengue, chikungunya and now VZIK infection, which are transmitted by the Aedes mosquito, hence the vector control is essential in the fight against these diseases(AU)",LILACS,March 31, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Yes,Review,No,Yes,248,Clinical/epidemiological research,Epidemiological/clinical review
249,"Yasri, Asian Pacific Journal of Tropical Disease, 2015",Yasri,"Yasri, S., Wiwanitkit, V.","New human pathogenic dengue like virus infections (Zika, Alkhumraand Mayaro viruses): A short review",Asian Pacific Journal of Tropical Disease,5,S1,S31-S32,2015,2010-present,,2015141973,http://dx.doi.org/10.1016/S2222-1808%2815%2960851-9,1607,English,"http://www.elsevier.com/wps/find/journaldescription.cws_home/726379/description#description, http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emed13&AN=2015141973","(Yasri) KMT Primary Care Center, Bangkok, Thailand (Wiwanitkit) Hainan Medical University, Haikou, China, S. Yasri, KMT Primary Care Center, Bangkok, Thailand",,,,,"Alkhumra, Dengue, Mayaro, Virus, Zika, Alkhumra virus, Alkhumra virus infection, Arbovirus, arthralgia/co [Complication], conjunctivitis/co [Complication], cost effectiveness analysis, editorial, endemic disease, epidemic, human, Mayaro virus, Mayaro virus infection, nonhuman, polymerase chain reaction, priority journal, rash/co [Complication], serology, treatment planning, virus infection, virus transmission, Zika virus, Zika virus infection, immunoglobulin M/ec [Endogenous Compound]","Dengue is an important pathogenic arbovirus that causes acute febrile illness with hemorrhagic complication. This disease is an important tropical disease that is the present public health threat. To diagnose dengue, it is usually based on clinical diagnosis. However, there are many dengues like infections that can be easily missed diagnosed. In the past decades, there are many new emerging dengues like infections that should be mentioned. Here, the authors briefly review on 2 important new human pathogenic dengue like virus infections (Zika, Alkhumra and Mayaro viruses).",Embase,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Yes,Review,No,Yes,249,Clinical/epidemiological research,Epidemiological/clinical review
250,"Mattar V., , 2015",Mattar V.,"Mattar V., Salim; González T., Marco",Now is the time for the Zika virus,,20,,4511-4512,2015,2010-present,,,,1819,,http://www.scielo.org.co/scielo.php?script=sci_arttext&pid=S0122-02682015000200001&nrm=iso,,,,,,,,LILACS,March 31, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,250,,
251,"Halstead, F1000Res, 2015",Halstead,"Halstead, S. B.",Pathogenesis of Dengue: Dawn of a New Era,F1000Res,4,,,2015,2010-present,,26918141,10.12688/f1000research.7024.1,1840,,http://www.ncbi.nlm.nih.gov/pubmed/26918141,"Dengue Vaccine Initiative, International Vaccine Institute, Seoul, Korea, South.",,,,,"Dengue pathogenesis, Dengue virus, dengue shock syndrome, dengue vascular permeability syndrome, hemorrhagic fever, viral toxicosis","Dengue virus (DENV) infections of humans were long thought to be self-limited and of low mortality. Beginning in the 1950s, at the time when four different DENVs were discovered, a lethal variant of dengue emerged. Dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS) initially observed in Southeast Asia now has spread throughout the world. Two risk factors for DHF/DSS are well-established: severe disease occurs during a second heterotypic DENV infection or during a first DENV infection in infants born to dengue-immune mothers. A large number of hypotheses have been proposed to explain severe dengue disease. As discussed, few of them attempt to explain why severe disease occurs under the two different immunological settings. New experimental evidence has demonstrated that DENV non-structural protein 1 (NS1) is toll-receptor 4 agonist that stimulates primary human myeloid cells to produce the same cytokines observed during the course of severe dengue disease. In addition, NS1 directly damages endothelial cells. These observations have been repeated and extended to an in vivo mouse model. The well-established phenomenon, antibody-dependent enhancement of DENV infection in Fc-receptor-bearing cells, should similarly enhance the production of DENV NS1 in humans, providing a unitary mechanism for severe disease in both immunological settings.",F1000,March 31, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Review,No,Yes,251,Basic and applied biomedical research,Basic research review
252,"Ministério da Saúde. Secretaria de Atenção à Saúde. Brasil, , 2015",Ministério da Saúde. Secretaria de Atenção à Saúde. Brasil,Ministério da Saúde. Secretaria de Atenção à Saúde. Brasil,Protocolo de atenção à saúde e resposta à ocorrência de microcefalia relacionada à infecção pelo vírus Zika / Protocol for health care and response to the occurrence of microcephaly related to Zika virus infection / Protocolo de atención a la salud y respuesta a la ocurrencia de casos de microcefalia relacionada com la infección por el virus Zika.,,,,,2015,2010-present,,,,1818,,http://portalsaude.saude.gov.br/images/pdf/2016/marco/01/coes-microcefalia-informe-epid15-se08-2016-01mar2016.pdf,,,,,,,,LILACS,March 31, 2016,No,No full-text obtained yet,,,Surveillance report or data,,,No,Yes,252,Clinical/epidemiological research,Ecological study/outbreak report
253,"ECDC, , 2015",ECDC,ECDC,Rapid risk assessment. Microcephaly in Brazil potentially linked to the Zika virus epidemic - 24 November 2015,,,,,2015,2010-present,,,,1870,,,,Sweden,Europe,,Public/Government,,,ECDC,March 31, 2016,Yes,,No,"Zika, indirect evidence or other topic",Surveillance report or data,,,No,Yes,253,Clinical/epidemiological research,Ecological study/outbreak report
254,"ECDC, , 2015",ECDC,ECDC,Rapid risk assessment. Zika virus epidemic in the Americas: potential association with microcephaly and Guillain-Barré syndrome - 10 December 2015,,,,,2015,2010-present,,,,1871,,,,Sweden,Europe,,Public/Government,,,ECDC,March 31, 2016,Yes,,No,"Zika, indirect evidence or other topic",Surveillance report or data,,,No,Yes,254,Clinical/epidemiological research,Ecological study/outbreak report
255,"ECDC, , 2015",ECDC,ECDC,"Rapid risk assessment. Zika virus infection outbreak, Brazil and the Pacific region - 25 May 2015",,,,,2015,2010-present,,,,1869,,,,Sweden,Europe,,Public/Government,,,ECDC,March 31, 2016,Yes,,No,"Zika, indirect evidence or other topic",Surveillance report or data,,,No,Yes,255,Clinical/epidemiological research,Ecological study/outbreak report
256,"Freire, bioRxiv, 2015",Freire,"Freire, Caio Cesar de Melo, Iamarino, Atila, Neto, Daniel Ferreira de Lima, Sall, Amadou Alpha, Zanotto, Paolo Marinho de Andrade",Spread of the pandemic Zika virus lineage is associated with NS1 codon usage adaptation in humans,bioRxiv,,,,2015,2010-present,,,10.1101/032839,1949,,http://biorxiv.org/content/biorxiv/early/2015/11/25/032839.full.pdf,,Brazil,Americas,Brazil,,,"Zika virus (ZIKV) infections were more common in the zoonotic cycle until the end of the 20th century with few human cases in Africa and Southeastern Asia. Recently, the Asian lineage of ZIKV is spreading along human-to-human chains of transmission in the Pacific Islands and in South America. To better understand its recent urban expansion, we compared genetic differences among the lineages. Herein we show that the recent Asian lineage spread is associated with significant NS1 codon usage adaptation to human housekeeping genes, which could facilitate viral replication and increase viral titers. These findings were supported by a significant correlation with growth in Malthusian fitness. Furthermore, we predicted several epitopes in the NS1 protein that are shared between ZIKV and Dengue. Our results imply in a significant dependence of the recent human ZIKV spread on NS1 translational selection.",BiorXiv,March 31, 2016,Yes,,No,"Zika, indirect evidence or other topic",Scientific (journal) article,No,Original research,No,Yes,256,Basic and applied biomedical research,Sequence analysis and phylogenetics
257,"Nau, Revue Medicale Suisse, 2015",Nau,"Nau, J. Y.",The nervous and lymphatic systems communicate. The 'zika virus' deliver its mysteries,Revue Medicale Suisse,11,481,1462-1463,2015,2010-present,,2015200253,,1605,English,,J.-Y. Nau,,,,,"lymphatic system, nervous system, short survey",,Embase,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,257,,
258,"Mende, Pharmazeutische Zeitung, 2015",Mende,"Mende, A.",Zika virus in South America: Travel guidelines for pregnant women,Pharmazeutische Zeitung,160,49,,2015,2010-present,,20160086247,,1569,English,"http://www.pharmazeutische-zeitung.de/index.php?id=61100, http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emed13&AN=20160086247",A. Mende,,,,,"female, human, nonhuman, note, pregnant woman, South America, travel, virus, zika virus",,Embase,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Yes,Review,No,Yes,258,Clinical/epidemiological research,Guidelines
259,"Joob, Annals of Tropical Medicine and Public Health, 2015",Joob,"Joob, B., Wiwanitkit, V.",Zika virus infection and dengue: A new problem in diagnosis in a dengue-endemic area,Annals of Tropical Medicine and Public Health,8,4,145-146,2015,2010-present,,2015306404,http://dx.doi.org/10.4103/1755-6783.162402,1599,English,http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emed13&AN=2015306404,"(Joob) Sanitation 1 Medical Academic Center, Bangkok, Thailand (Wiwanitkit) Hainan Medical University, Haikou, China (Wiwanitkit) University of Nis, Serbia (Wiwanitkit) Joseph Ayobabalola University, Nigeria (Wiwanitkit) Dr. DY Patil Medical University, India, B. Joob, Sanitation 1 Medical Academic Center, Bangkok, Thailand",,,,,"dengue/di [Diagnosis], endemic disease, human, letter, serology, virus infection/di [Diagnosis], Zika virus infection/di [Diagnosis], immunoglobulin M/ec [Endogenous Compound]","Dear Sir,    Zika is an important new emerging viral infection. [1] It is classified as a Flavivirus, and has a great similarity to other mosquito-borne infections. [1],[2] It has been recently included in the list of new emerging infectious diseases to be focused on. [2] Interestingly, the clinical manifestation of Zika virus infection is greatly similar to dengue, the most common arboviral infection in the tropical world. Due to the common clinical presentation, problems regarding the missed diagnosis and underdiagnosis of Zika virus infection in an endemic area of dengue can be expected. Interestingly, in a dengue-endemic area, the presumptive diagnosis of dengue is usually done without a standard confirmed diagnosis. In some cases, the use of immunoglobulin M (IgM) serology test is used for the diagnosis of dengue in a certain setting. [3] In addition, the false positive to dengue IgM serological test can be seen in Zika virus infection. Hence, it can be expected that there are many cases of Zika virus infection circulating in an endemic area of dengue without a proven diagnosis and in cases of a misdiagnosis of dengue. Interestingly, there are some recent reports on an imported case of Zika virus infection in Europe and on tracing history, it has been shown that the primary origin of this infection is from dengue-endemic areas such as Thailand.",Embase,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,No,Comment/Editorial/Perspective/Letter,No,Yes,259,,
260,"[No authors listed], Wkly Epidemiol Rec, 2015",[No authors listed],[No authors listed],Zika virus outbreaks in the Americas,Wkly Epidemiol Rec,90,45,609-10,2015,2010-present,,26552108,,1961,,http://www.who.int/wer/2015/wer9045.pdf?ua=1,,,,,,"Aedes/virology; Animals; Brazil/epidemiology; Chile/epidemiology; Colombia/epidemiology; Communicable Diseases, Emerging/*epidemiology/transmission/*virology; Disease Vectors; Humans; *Zika Virus; Zika Virus Infection/*epidemiology/transmission/*virology",,Pubmed,March 31, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Surveillance report or data,,,No,Yes,260,Clinical/epidemiological research,Ecological study/outbreak report
261,"Martinez-Pulgarin, Travel Med Infect Dis, 2016",Martinez-Pulgarin,"Martinez-Pulgarin, D. F.; Acevedo-Mendoza, W. F.; Cardona-Ospina, J. A.; Rodriguez-Morales, A. J.; Paniz-Mondolfi, A. E.",A bibliometric analysis of global Zika research,Travel Med Infect Dis,14,1,55-7,2016,2010-present,August 11, 2015,26257029,10.1016/j.tmaid.2015.07.005,1373,English,http://www.ncbi.nlm.nih.gov/pubmed/26257029,"Public Health and Infection Research and Incubator Group, Faculty of Health Sciences, Universidad Tecnologica de Pereira, Pereira, Risaralda, Colombia.; Public Health and Infection Research and Incubator Group, Faculty of Health Sciences, Universidad Tecnologica de Pereira, Pereira, Risaralda, Colombia. Electronic address: arodriguezm@utp.edu.co.; Department of Pathology and Laboratory Medicine, Hospital Internacional, Barquisimeto, Venezuela and The Laboratory of Biochemistry, Instituto de Biomedicina/IVSS, Caracas, Venezuela.",,,,,,,Pubmed,March 31, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Yes,Review,No,Yes,261,Clinical/epidemiological research,Qualitative study
262,"Aubry, Transfusion, 2016",Aubry,"Aubry, M.; Richard, V.; Green, J.; Broult, J.; Musso, D.",Inactivation of Zika virus in plasma with amotosalen and ultraviolet A illumination,Transfusion,56,1,33-40,2016,2010-present,August 19, 2015,26283013,10.1111/trf.13271,1372,English,http://www.ncbi.nlm.nih.gov/pubmed/26283013,"Pole de Recherche et de Veille sur les Maladies Infectieuses Emergentes, Institut Louis Malarde, Tahiti, French Polynesia.; Cerus Corporation, Concord, California.; Centre de Transfusion Sanguine de la Polynesie Francaise, Hopital Du Taaone, Tahiti, French Polynesia.",,,,,,"BACKGROUND: Zika virus (ZIKV) is an arthropod-borne virus (arbovirus) transmitted by mosquitoes. The potential for ZIKV transmission through blood transfusion was demonstrated during the ZIKV outbreak that occurred in French Polynesia from October 2013 to April 2014. Pathogen inactivation of blood products is a proactive strategy that provides the potential to reduce transfusion-transmitted diseases. Inactivation of arboviruses by amotosalen and ultraviolet A (UVA) illumination was previously demonstrated for chikungunya, West Nile, and dengue viruses. We report here the efficiency of this process for ZIKV inactivation of human plasma. STUDY DESIGN AND METHODS: Plasma units were spiked with ZIKV. Viral titers and RNA loads were measured in plasma before and after amotosalen and UVA photochemical treatment. RESULTS: The mean ZIKV titers and RNA loads in plasma before inactivation were respectively 6.57 log TCID50 /mL and 10.25 log copies/mL. After inactivation, the mean ZIKV RNA loads was 9.51 log copies/mL, but cell cultures inoculated with inactivated plasma did not result in infected cells and did not produce any replicative virus after one passage, nor detectable viral RNA from the second passage. CONCLUSION: In this study we demonstrate that amotosalen combined with UVA light inactivates ZIKV in fresh-frozen plasma. This inactivation process is of particular interest to prevent plasma transfusion-transmitted ZIKV infections in areas such as French Polynesia, where several arboviruses are cocirculating.",Pubmed,March 31, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Original research,No,Yes,262,Basic and applied biomedical research,Other basic research
263,"Tognarelli, Arch Virol, 2016",Tognarelli,"Tognarelli, J., Ulloa, S., Villagra, E., Lagos, J., Aguayo, C., Fasce, R., Parra, B., Mora, J., Becerra, N., Lagos, N., Vera, L., Olivares, B., Vilches, M., Fernandez, J.","A report on the outbreak of Zika virus on Easter Island, South Pacific, 2014",Arch Virol,161,3,665-8,2016,2010-present,November 28, 2015,26611910,10.1007/s00705-015-2695-5,1360,English,,"Subdepartment of Molecular Genetics, Public Health Institute of Chile, Santiago, Chile., Emergent and Hepatic Virus Laboratory, Public Health Institute of Chile, Santiago, Chile., Subdepartment of Virology, Public Health Institute of Chile, Santiago, Chile., Subdepartment of Molecular Genetics, Public Health Institute of Chile, Santiago, Chile. jfernand@ispch.cl.",,,,,"Easter Island, Outbreak, South Pacific, Zikv, Zika virus","Zika virus (ZIKV) is an emerging mosquito-borne flavivirus circulating in Asia and Africa. In 2013, a large outbreak was reported on the archipelago of French Polynesia. In this study, we report the detection and molecular characterization of Zika virus for the first time in Chile from an outbreak among the inhabitants of Easter Island. A total of 89 samples from patients suspected of having ZIKV infection were collected between the period from January to May, 2014. Molecular diagnosis of the virus was performed by RT-PCR followed by the sequencing of the region containing the NS5 gene. A comparison of the viral nucleic acid sequence with those of other strains of ZIKA virus was performed using the MEGA software. Fifty-one samples were found positive for ZIKV by RT-PCR analysis. Further analysis of the NS5 gene revealed that the ZIKV strains identified in Easter Island were most closely related to those found in French Polynesia (99.8 to 99.9 % nt and 100 % aa sequence identity). These results strongly suggest that the transmission pathway leading to the introduction of Zika virus on Easter Island has its origin in French Polynesia.",Pubmed,March 31, 2016,Yes,,No,"Zika, indirect evidence or other topic",Scientific (journal) article,Yes,Original research,No,Yes,263,Basic and applied biomedical research,Sequence analysis and phylogenetics
264,"Calvet, J Clin Virol, 2016",Calvet,"Calvet, G. A.; Filippis, A. M.; Mendonca, M. C.; Sequeira, P. C.; Siqueira, A. M.; Veloso, V. G.; Nogueira, R. M.; Brasil, P.","First detection of autochthonous Zika virus transmission in a HIV-infected patient in Rio de Janeiro, Brazil",J Clin Virol,74,,01. Mrz,2016,2010-present,November 30, 2015,26615388,10.1016/j.jcv.2015.11.014,1359,English,http://www.ncbi.nlm.nih.gov/pubmed/26615388,"Acute Febrile Illnesses Laboratory, Evandro Chagas National Institute of Infectious Diseases, Av Brasil 4365, Manguinhos, Rio de Janeiro, Rio de Janeiro 21045-360, Brazil. Electronic address: guilherme.calvet@ini.fiocruz.br.; Flavivirus Laboratory, Oswaldo Cruz Institute/Oswaldo Cruz Foundation, Av Brasil 4365, Manguinhos, Rio de Janeiro, Rio de Janeiro 21045-360, Brazil. Electronic address: abispo@ioc.fiocruz.br.; Flavivirus Laboratory, Oswaldo Cruz Institute/Oswaldo Cruz Foundation, Av Brasil 4365, Manguinhos, Rio de Janeiro, Rio de Janeiro 21045-360, Brazil. Electronic address: marcosclm@ioc.fiocruz.br.; Flavivirus Laboratory, Oswaldo Cruz Institute/Oswaldo Cruz Foundation, Av Brasil 4365, Manguinhos, Rio de Janeiro, Rio de Janeiro 21045-360, Brazil. Electronic address: patricia@ioc.fiocruz.br.; Acute Febrile Illnesses Laboratory, Evandro Chagas National Institute of Infectious Diseases, Av Brasil 4365, Manguinhos, Rio de Janeiro, Rio de Janeiro 21045-360, Brazil. Electronic address: andre.siqueira@ini.fiocruz.br.; STD/AIDS Clinical Research Laboratory, Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation, Av Brasil 4365, Manguinhos, Rio de Janeiro, Rio de Janeiro 21045-360, Brazil. Electronic address: valdilea.veloso@gmail.com.; Flavivirus Laboratory, Oswaldo Cruz Institute/Oswaldo Cruz Foundation, Av Brasil 4365, Manguinhos, Rio de Janeiro, Rio de Janeiro 21045-360, Brazil. Electronic address: rita@ioc.fiocruz.br.; Acute Febrile Illnesses Laboratory, Evandro Chagas National Institute of Infectious Diseases, Av Brasil 4365, Manguinhos, Rio de Janeiro, Rio de Janeiro 21045-360, Brazil. Electronic address: patricia.brasil@ini.fiocruz.br.",,,,,Arbovirus; Brazil; Hiv; Zikv; Zika,"Since May 2015, Brazil's Ministry of Health has reported autochthonous transmission of Zika virus (ZIKV) in some states of the country. Simultaneous circulation of Dengue, Chikungunya and ZIKV in the country hinder both the diagnosis and the therapeutic approach of patients seeking care with acute febrile illnesses especially in patients with comorbidities. The association between HIV infection and endemic diseases has been described especially in tropical regions with varying levels of complications, although there has been no report of ZIKV in HIV-infected patients. We report the first autochthonous case of laboratory confirmed ZIKV infection in a HIV-infected patient in Rio de Janeiro, Brazil. He evolved with only mild symptoms and recovered well without major laboratory abnormalities. Phylogenetic analysis of the ZIKV detected in the patient sera clustered within the Asian clade. To the best of our knowledge, this is the first time that Zika virus co-infection is reported in a HIV-infected patient.",Pubmed,March 31, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Original research,No,Yes,264,Clinical/epidemiological research,Case report
265,"Salvador, Travel Med Infect Dis, 2016",Salvador,"Salvador, F. S.; Fujita, D. M.",Entry routes for Zika virus in Brazil after 2014 world cup: New possibilities,Travel Med Infect Dis,14,1,49-51,2016,2010-present,December 3, 2015,26627575,10.1016/j.tmaid.2015.10.004,1358,English,http://www.ncbi.nlm.nih.gov/pubmed/26627575,"Instituto de Medicina Tropical de Sao Paulo, USP, Sao Paulo, Brazil.; Instituto de Medicina Tropical de Sao Paulo, USP, Sao Paulo, Brazil. Electronic address: dmfujita@usp.br.",,,,,Brazil; Travelers; World cup; Zika virus,,Pubmed,March 31, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,No,Comment/Editorial/Perspective/Letter,No,Yes,265,,
266,"Franchini, Blood Transfus, 2016",Franchini,"Franchini, M.; Velati, C.",Blood safety and zoonotic emerging pathogens: now it's the turn of Zika virus!,Blood Transfus,14,2,93-4,2016,2010-present,December 18, 2015,26674809,10.2450/2015.0187-15,1357,English,http://www.ncbi.nlm.nih.gov/pubmed/26674809,"Department of Haematology and Transfusion Medicine, Carlo Poma Hospital, Mantua, Italy.; Transfusion Medicine and Immunohaematology Department of Bologna Metropolitan Area, Bologna, Italy.; Emilia-Romagna Regional Blood Centre, Bologna, Italy.",,,,,,,Pubmed,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,266,,
267,"Marano, Blood Transfus, 2016",Marano,"Marano, G., Pupella, S., Vaglio, S., Liumbruno, G. M., Grazzini, G.",Zika virus and the never-ending story of emerging pathogens and Transfusion Medicine,Blood Transfus,14,2,95-100,2016,2010-present,December 18, 2015,26674815,10.2450/2015.0066-15,1356,English,,"Italian National Blood Centre, National Institute of Health, Rome, Italy., Faculty of Medicine and Psychology, 'Sapienza' University of Rome, Rome, Italy.",,,,,,"In the last few years, the transfusion medicine community has been paying special attention to emerging vector-borne diseases transmitted by arboviruses. Zika virus is the latest of these pathogens and is responsible for major outbreaks in Africa, Asia and, more recently, in previously infection-naive territories of the Pacific area. Many issues regarding this emerging pathogen remain unclear and require further investigation. National health authorities have adopted different prevention strategies. The aim of this review article is to discuss the currently available, though limited, information and the potential impact of this virus on transfusion medicine.",Pubmed,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Yes,Review,No,Yes,267,Basic and applied biomedical research,Other basic research
268,"Gatherer, J Gen Virol, 2016",Gatherer,"Gatherer, D., Kohl, A.",Zika virus: a previously slow pandemic spreads rapidly through the Americas,J Gen Virol,97,2,269-73,2016,2010-present,December 20, 2015,26684466,10.1099/jgv.0.000381,1355,English,,"1Division of Biomedical & Life Sciences, Faculty of Health & Medicine, Lancaster University, Lancaster LA1 4YW, UK., 2MRC-University of Glasgow Centre for Virus Research, Glasgow G61 1QH, UK.",,,,,,"Zika virus (family Flaviviridae) is an emerging arbovirus. Spread by Aedes mosquitoes, it was first discovered in Uganda in 1947, and later in humans elsewhere in sub-Saharan Africa, arriving in south-east Asia at latest by the mid-twentieth century. In the twenty-first century, it spread across the Pacific islands reaching South America around 2014. Since then it has spread rapidly northwards reaching Mexico in November 2015. Its clinical profile is that of a dengue-like febrile illness, but associations with Guillain-Barre syndrome and microcephaly have appeared recently. The final geographical range and ultimate clinical impact of Zika virus are still a matter for speculation.",Pubmed,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Yes,Review,No,Yes,268,Basic and applied biomedical research,Basic research review
269,"Brown, Cmaj, 2016",Brown,"Brown, C.",Zika virus outbreaks in Asia and South America,Cmaj,188,2,E34,2016,2010-present,December 24, 2015,26696621,10.1503/cmaj.109-5212,1353,English,,"Ottawa, Ont.",,,,,,,Pubmed,March 31, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",News item or lay press,,,No,Yes,269,,
270,"Kelser, Microbes Infect, 2016",Kelser,"Kelser, E. A.","Meet dengue's cousin, Zika",Microbes Infect,18,3,163-6,2016,2010-present,December 27, 2015,26706817,10.1016/j.micinf.2015.12.003,1350,English,http://www.ncbi.nlm.nih.gov/pubmed/26706817,"P.O. Box 254, Norwalk, OH 44857, USA. Electronic address: erinkelserus@gmail.com.",,,,,,,Pubmed,March 31, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,270,,
271,"Oliveira Melo, Ultrasound Obstet Gynecol, 2016",Oliveira Melo,"Oliveira Melo, A. S., Malinger, G., Ximenes, R., Szejnfeld, P. O., Alves Sampaio, S., Bispo de Filippis, A. M.",Zika virus intrauterine infection causes fetal brain abnormality and microcephaly: tip of the iceberg?,Ultrasound Obstet Gynecol,47,1,06. Jul,2016,2010-present,January 6, 2016,26731034,10.1002/uog.15831,1348,English,http://onlinelibrary.wiley.com/doi/10.1002/uog.15831/epdf,"Division of Ultrasound in Obstetrics & Gynecology, Lis Maternity Hospital, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel  gmalinger@gmail.com",Brazil,Americas,Brazil,Not reported/unknown,,,Pubmed,March 31, 2016,Yes,,Yes,,Scientific (journal) article,Yes,Original research,Yes,No,355,Clinical/epidemiological research,Case series
272,"Sabogal-Roman, Travel Med Infect Dis, 2016",Sabogal-Roman,"Sabogal-Roman, J. A.; Murillo-Garcia, D. R.; Yepes-Echeverri, M. C.; Restrepo-Mejia, J. D.; Granados-Alvarez, S.; Paniz-Mondolfi, A. E.; Villamil-Gomez, W. E.; Zapata-Cerpa, D. C.; Barreto-Rodriguez, K.; Rodriguez-Morales, A. J.","Healthcare students and workers' knowledge about transmission, epidemiology and symptoms of Zika fever in four cities of Colombia",Travel Med Infect Dis,14,1,52-4,2016,2010-present,January 11, 2016,26748604,10.1016/j.tmaid.2015.12.003,1347,English,http://www.ncbi.nlm.nih.gov/pubmed/26748604,"Public Health and Infection Research Incubator and Group, Faculty of Health Sciences, Universidad Tecnologica de Pereira, Pereira, Risaralda, Colombia.; Department of Pathology and Laboratory Medicine, Hospital Internacional, Barquisimeto, Venezuela and the Laboratory of Biochemistry, Instituto de Biomedicina / Instituto Venezolano de los Seguros Sociales (IVSS), Caracas, Venezuela; Working Group on Zoonoses, International Society for Chemotherapy, Aberdeen, UK; Committee on Travel Medicine, Pan-American Association of Infectious Diseases, Quito, Ecuador.; Committee on Travel Medicine, Pan-American Association of Infectious Diseases, Quito, Ecuador; Infectious Diseases and Infection Control Research Group, Hospital Universitario de Sincelejo, Sincelejo, Sucre, Colombia; Programa del Doctorado de Medicina Tropical, Universidad de Cartagena, Cartagena, Universidad del Atlantico, Barranquilla, Colombia; Committee on Zoonoses and Haemorrhagic Fevers, Asociacion Colombiana de Infectologia, Bogota, DC, Colombia.; Infectious Diseases and Infection Control Research Group, Hospital Universitario de Sincelejo, Sincelejo, Sucre, Colombia.; Grupo de Investigacion, Corporacion Universitaria Antonio Jose de Sucre CORPOSUCRE, Sincelejo, Sucre, Colombia.; Public Health and Infection Research Incubator and Group, Faculty of Health Sciences, Universidad Tecnologica de Pereira, Pereira, Risaralda, Colombia; Working Group on Zoonoses, International Society for Chemotherapy, Aberdeen, UK; Committee on Travel Medicine, Pan-American Association of Infectious Diseases, Quito, Ecuador; Infectious Diseases and Infection Control Research Group, Hospital Universitario de Sincelejo, Sincelejo, Sucre, Colombia; Committee on Zoonoses and Haemorrhagic Fevers, Asociacion Colombiana de Infectologia, Bogota, DC, Colombia. Electronic address: arodriguezm@utp.edu.co.",,,,,Colombia; Epidemiology; Knowledge; Latin America; Zika,,Pubmed,March 31, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Original research,No,Yes,272,Clinical/epidemiological research,Qualitative study
273,"Attar, Nat Rev Microbiol, 2016",Attar,"Attar, N.",ZIKA virus circulates in new regions,Nat Rev Microbiol,14,2,62,2016,2010-present,January 12, 2016,26751510,10.1038/nrmicro.2015.28,1346,English,,,,,,,,,Pubmed,March 31, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",News item or lay press,,,No,Yes,273,,
274,"Villamil-Gomez, J Infect Public Health, 2016",Villamil-Gomez,"Villamil-Gomez, W. E.; Gonzalez-Camargo, O.; Rodriguez-Ayubi, J.; Zapata-Serpa, D.; Rodriguez-Morales, A. J.","Dengue, chikungunya and Zika co-infection in a patient from Colombia",J Infect Public Health,,,,2016,2010-present,January 13, 2016,26754201,10.1016/j.jiph.2015.12.002,1345,English,http://www.ncbi.nlm.nih.gov/pubmed/26754201,"Infectious Diseases and Infection Control Research Group, Hospital Universitario de Sincelejo, Sincelejo, Sucre, Colombia; Programa del Doctorado de Medicina Tropical, Universidad de Cartagena, Cartagena, Colombia; Universidad del Atlantico, Barranquilla, Colombia; Committee on Zoonoses and Haemorrhagic Fevers, Asociacion Colombiana de Infectologia, Bogota, DC, Colombia.; Epidemiology Division, Hospital Universitario de Sincelejo, Sincelejo, Sucre, Colombia.; Grupo de Investigacion, Corporacion Universitaria Antonio Jose de Sucre, Corposucre, Sincelejo, Colombia.; Infectious Diseases and Infection Control Research Group, Hospital Universitario de Sincelejo, Sincelejo, Sucre, Colombia.; Public Health and Infection Research and Incubator Group, Faculty of Health Sciences, Universidad Tecnologica de Pereira, Pereira, Risaralda, Colombia; Committee on Zoonoses and Haemorrhagic Fevers, Colombia; Asociacion Colombiana de Infectologia, Bogota, DC, Colombia; Organizacion Latinoamericana para el Fomento de la Investigacion en Salud (OLFIS), Bucaramanga, Santander, Colombia. Electronic address: arodriguezm@utp.edu.co.",,,,,,,Pubmed,March 31, 2016,Yes,,No,"Zika, not relevant to causality framework",Scientific (journal) article,Unknown/unclear,Original research,No,Yes,274,Clinical/epidemiological research,Case report
275,"Fauci, N Engl J Med, 2016",Fauci,"Fauci, A. S., Morens, D. M.",Zika Virus in the Americas--Yet Another Arbovirus Threat,N Engl J Med,374,7,601-4,2016,2010-present,January 14, 2016,26761185,10.1056/NEJMp1600297,1344,English,,"From the National Institute of Allergy and Infectious Diseases, Bethesda, MD.",,,,,"Aedes/growth & development/virology, Americas/epidemiology, Animals, Arboviruses, Biological Evolution, Chikungunya Fever/diagnosis, Communicable Diseases, Emerging/*epidemiology, Diagnosis, Differential, Humans, Life Cycle Stages, *Pandemics, *Zika Virus/genetics, Zika Virus Infection/complications/diagnosis/*epidemiology/transmission",,Pubmed,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,275,,
276,"McCarthy, BMJ, 2016",McCarthy,"McCarthy, M.",First US case of Zika virus infection is identified in Texas,BMJ,352,,i212,2016,2010-present,January 15, 2016,26762624,10.1136/bmj.i212,1343,English,http://www.ncbi.nlm.nih.gov/pubmed/26762624,Seattle.,,,,,,,Pubmed,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,News item or lay press,,,No,Yes,276,,
277,"Carneiro, Microbes Infect, 2016",Carneiro,"Carneiro, L. A.; Travassos, L. H.",Autophagy and viral diseases transmitted by Aedes aegypti and Aedes albopictus,Microbes Infect,18,3,169-71,2016,2010-present,January 18, 2016,26774331,10.1016/j.micinf.2015.12.006,1341,English,http://www.ncbi.nlm.nih.gov/pubmed/26774331,"Instituto de Microbiologia Paulo de Goes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil. Electronic address: leticiac@micro.ufrj.br.; Instituto de Biofisica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil. Electronic address: leo.travassos@biof.ufrj.br.",,,,,Aedes aegypti; Autophagy; Chikungynya virus; Dengue virus; Zika virus,"Despite a long battle that was started by Oswaldo Cruz more than a century ago, in 1903, Brazil still struggles to fight Aedes aegypti and Aedes albopictus, the mosquito vectors of dengue virus (DENV), Chikungynya virus (CHIKV) and Zika virus (ZIKV). Dengue fever has been a serious public health problem in Brazil for decades, with recurrent epidemic outbreaks occurring during summers. In 2015, until November, 1,534,932 possible cases were reported to the Ministry of Healthv [1]. More recently, the less studied CHIKV and ZIKV have gained attention because of a dramatic increase in their incidence (around 400% for CHIKV) and the association of ZIKV infection with a 11-fold increase in the number of cases of microcephaly from 2014 to 2015 in northeast Brazil (1761 cases until December 2015) [1]. The symptoms of these three infections are very similar, which complicates the diagnosis. These include fever, headache, nausea, fatigue, and joint pain. In some cases, DENV infection develops into dengue hemorrhagic fever, a life threatening condition characterized by bleeding and decreases in platelet numbers in the blood. As for CHIKV, the most important complication is joint pain, which can last for months.",Pubmed,March 31, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,277,,
278,"Bourtzis, Acta Trop, 2016",Bourtzis,"Bourtzis, K.; Lees, R. S.; Hendrichs, J.; Vreysen, M. J.","More than one rabbit out of the hat: Radiation, transgenic and symbiont-based approaches for sustainable management of mosquito and tsetse fly populations",Acta Trop,157,,115-30,2016,2010-present,January 18, 2016,26774684,10.1016/j.actatropica.2016.01.009,1340,English,http://www.ncbi.nlm.nih.gov/pubmed/26774684,"Insect Pest Control Sub-programme, Joint FAO/IAEA Division of Nuclear Techniques in Food and Agriculture, Vienna, Austria. Electronic address: K.Bourtzis@iaea.org.; Insect Pest Control Sub-programme, Joint FAO/IAEA Division of Nuclear Techniques in Food and Agriculture, Vienna, Austria. Electronic address: R.S.Lees@iaea.org.; Insect Pest Control Sub-programme, Joint FAO/IAEA Division of Nuclear Techniques in Food and Agriculture, Vienna, Austria. Electronic address: J.Hendrichs@iaea.org.; Insect Pest Control Sub-programme, Joint FAO/IAEA Division of Nuclear Techniques in Food and Agriculture, Vienna, Austria. Electronic address: M.Vreysen@iaea.org.",,,,,Mosquitoes; Sodalis; Sterile insect technique; Tsetse flies; Vectors; Wolbachia,"Mosquitoes (Diptera: Culicidae) and tsetse flies (Diptera: Glossinidae) are bloodsucking vectors of human and animal pathogens. Mosquito-borne diseases (malaria, filariasis, dengue, zika, and chikungunya) cause severe mortality and morbidity annually, and tsetse fly-borne diseases (African trypanosomes causing sleeping sickness in humans and nagana in livestock) cost Sub-Saharan Africa an estimated US$ 4750 million annually. Current reliance on insecticides for vector control is unsustainable: due to increasing insecticide resistance and growing concerns about health and environmental impacts of chemical control there is a growing need for novel, effective and safe biologically-based methods that are more sustainable. The integration of the sterile insect technique has proven successful to manage crop pests and disease vectors, particularly tsetse flies, are improved. Transgenic and symbiont-based approaches are in development, and more and is likely to prove effective against mosquito vectors, particularly once sex-separation methods advanced in (particularly Aedes) mosquitoes than in tsetse flies; however, issues around stability, sustainability and biosecurity have to be addressed, especially when considering population replacement approaches. Regulatory issues and those relating to intellectual property and economic cost of application must also be overcome. Standardised methods to assess insect quality are required to compare and predict efficacy of the different approaches. Different combinations of these three approaches could be integrated to maximise their benefits, and all have the potential to be used in tsetse and mosquito area-wide integrated pest management programmes.",Pubmed,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Yes,Review,No,Yes,278,Environmental and vector research,Ecological/Vector review
279,"Tetro, Microbes Infect, 2016",Tetro,"Tetro, J. A.","Zika and microcephaly: causation, correlation, or coincidence?",Microbes Infect,18,3,167-8,2016,2010-present,January 18, 2016,26774330,10.1016/j.micinf.2015.12.010,1342,English,,"130 Rosedale Valley Rd., Suite 103, Toronto, Ontario, M4W 1P9, Canada. Electronic address: jason@jasontetro.com.",,,,,,,Pubmed,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,No,Comment/Editorial/Perspective/Letter,No,Yes,279,,
280,"Enfissi, Lancet, 2016",Enfissi,"Enfissi, A., Codrington, J., Roosblad, J., Kazanji, M., Rousset, D.",Zika virus genome from the Americas,Lancet,387,10015,227-8,2016,2010-present,January 18, 2016,26775124,10.1016/s0140-6736(16)00003-9,1339,English,http://www.ncbi.nlm.nih.gov/pubmed/26775124,"Institut Pasteur de la Guyane, Laboratoire de Virologie, Cayenne, French Guiana, France., Laboratory Academisch Ziekenhuis, Paramaribo, Suriname., Institut Pasteur de la Guyane, Laboratoire de Virologie, Cayenne, French Guiana, France. Electronic address: drousset@pasteur-cayenne.fr.",,,,,,,Pubmed,March 31, 2016,Yes,,No,"Zika, indirect evidence or other topic",Scientific (journal) article,No,Original research,No,Yes,280,Basic and applied biomedical research,Sequence analysis and phylogenetics
281,"Ventura, Lancet, 2016",Ventura,"Ventura, C. V., Maia, M., Bravo-Filho, V., Gois, A. L., Belfort, R., Jr.",Zika virus in Brazil and macular atrophy in a child with microcephaly,Lancet,387,10015,228,2016,2010-present,January 18, 2016,26775125,10.1016/s0140-6736(16)00006-4,1338,English,http://www.thelancet.com/pdfs/journals/lancet/PIIS0140-6736%2816%2900006-4.pdf,"Altino Ventura Foundation, Recife, Brazil; Department of Ophthalmology, Federal University of Sao Paulo, Sao Paulo, Brazil., Department of Ophthalmology, Federal University of Sao Paulo, Sao Paulo, Brazil., Altino Ventura Foundation, Recife, Brazil; HOPE Eye Hospital, Recife, Brazil., Department of Ophthalmology, Federal University of Sao Paulo, Sao Paulo, Brazil. Electronic address: clinbelf@uol.com.br.",Brazil,Americas,Brazil,Not reported/unknown,,,Pubmed,March 31, 2016,Yes,,Yes,,Scientific (journal) article,Unknown/unclear,Original research,Yes,No,1058,Clinical/epidemiological research,Case series
282,"Bogoch, Lancet, 2016",Bogoch,"Bogoch, II; Brady, O. J.; Kraemer, M. U.; German, M.; Creatore, M. I.; Kulkarni, M. A.; Brownstein, J. S.; Mekaru, S. R.; Hay, S. I.; Groot, E.; Watts, A.; Khan, K.",Anticipating the international spread of Zika virus from Brazil,Lancet,387,10016,335-6,2016,2010-present,January 19, 2016,26777915,10.1016/S0140-6736(16)00080-5,1337,English,http://www.ncbi.nlm.nih.gov/pubmed/26777915,"Department of Medicine, Division of Infectious Diseases, University of Toronto, Toronto, Canada; Divisions of Internal Medicine and Infectious Diseases, University Health Network, Toronto, Canada.; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.; Spatial Ecology and Epidemiology Group, Department of Zoology, University of Oxford, Oxford, UK.; Li Ka Shing Knowledge Institute, St Michael's Hospital, Toronto, Canada.; 'Dalla Lana School of Public Health, University of Toronto, Toronto, Canada; Li Ka Shing Knowledge Institute, St Michael's Hospital, Toronto, Canada.; School of Epidemiology, Public Health and Preventive Medicine, University of Ottawa, Ottawa, Canada.; Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK; Institute for Health Metrics and Evaluation, University of Washington, Seattle, WA, USA; Fogarty International Center, National Institutes of Health, Bethesda, MD, USA.; Department of Medicine, Division of Infectious Diseases, University of Toronto, Toronto, Canada; Li Ka Shing Knowledge Institute, St Michael's Hospital, Toronto, Canada. Electronic address: khank@smh.ca.	Aedes/physiology/virology; Animals; Brazil/epidemiology; Disease Outbreaks; Humans; *Pandemics; Seasons; *Travel; Zika Virus/pathogenicity; Zika Virus Infection/*epidemiology/*transmission		NLM",,,,,,,Pubmed,March 31, 2016,Yes,,No,"Zika, not relevant to causality framework",Scientific (journal) article,Yes,Original research,No,Yes,282,Clinical/epidemiological research,Other clinical/epidemiological
283,"Gautret, Travel Med Infect Dis, 2016",Gautret,"Gautret, P.; Simon, F.","Dengue, chikungunya and Zika and mass gatherings: What happened in Brazil, 2014",Travel Med Infect Dis,14,1,07. Aug,2016,2010-present,January 19, 2016,26778293,10.1016/j.tmaid.2015.12.004,1336,English,http://www.ncbi.nlm.nih.gov/pubmed/26778293,"Department of Infectious Diseases and Tropical Medicine, Laveran Military Teaching Hospital, Marseille, France. Electronic address: philippe.gautret@club-internet.fr.; Department of Infectious Diseases and Tropical Medicine, Laveran Military Teaching Hospital, Marseille, France.",,,,,,,Pubmed,March 31, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,283,,
284,"Shinohara, J Travel Med, 2016",Shinohara,"Shinohara, K., Kutsuna, S., Takasaki, T., Moi, M. L., Ikeda, M., Kotaki, A., Yamamoto, K., Fujiya, Y., Mawatari, M., Takeshita, N., Hayakawa, K., Kanagawa, S., Kato, Y., Ohmagari, N.","Zika fever imported from Thailand to Japan, and diagnosed by PCR in the urines",J Travel Med,23,1,,2016,2010-present,January 20, 2016,26782128,10.1093/jtm/tav011,1335,English,,"Disease Control and Prevention Center, National Center for Global Health and Medicine, Tokyo, Japan and., Disease Control and Prevention Center, National Center for Global Health and Medicine, Tokyo, Japan and sonare.since1192@gmail.com., Department of Virology, National Institute of Infectious Diseases, Shinjuku-ku, Tokyo, Japan.",,,,,"Flaviviridae, Mosquito-borne disease, Zika fever","In July 2014, a Japanese traveller returning from Thailand was investigated for fever, headache, rash and conjunctivitis. Zika virus RNA was detected in his urine sample by real-time reverse transcription polymerase chain reaction. Serological tests showed cross reactivity of IgM against the dengue virus. Zika fever could be misdiagnosed or missed and should be considered in febrile patients with a rash, especially those returning from Thailand.",Pubmed,March 31, 2016,Yes,,No,"Zika, not relevant to causality framework",Scientific (journal) article,Yes,Original research,No,Yes,284,Clinical/epidemiological research,Case report
285,"McCarthy, BMJ, 2016",McCarthy,"McCarthy, M.",Zika virus outbreak prompts US to issue travel alert to pregnant women,BMJ,352,,i306,2016,2010-present,January 20, 2016,26783242,10.1136/bmj.i306,1334,English,,Seattle.,,,,,,,Pubmed,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,News item or lay press,,,No,Yes,285,,
286,"Calvez, PLoS Negl Trop Dis, 2016",Calvez,"Calvez, E.; Guillaumot, L.; Millet, L.; Marie, J.; Bossin, H.; Rama, V.; Faamoe, A.; Kilama, S.; Teurlai, M.; Mathieu-Daude, F.; Dupont-Rouzeyrol, M.","Genetic Diversity and Phylogeny of Aedes aegypti, the Main Arbovirus Vector in the Pacific",PLoS Negl Trop Dis,10,1,e0004374,2016,2010-present,January 23, 2016,26799213,10.1371/journal.pntd.0004374,1329,English,http://www.ncbi.nlm.nih.gov/pubmed/26799213,"URE-Dengue et autres Arboviroses, Institut Pasteur de Nouvelle-Caledonie, Reseau International Institut Pasteur, Noumea, New Caledonia.; URE-Entomologie Medicale, Institut Pasteur de Nouvelle-Caledonie, Reseau International Institut Pasteur, Noumea, New Caledonia.; UMR 9220, ENTROPIE, Institut de Recherche pour le Developpement, Noumea, New Caledonia.; Pole des Maladies Infectieuses et Emergentes, Institut Louis Malarde, Papeete, Tahiti.; Ministry of Health, Suva, Fiji.; Ministry of Health, Nuku'alofa, Kingdom of Tonga.; URE-Epidemiologie des Maladies Infectieuses, Institut Pasteur de Nouvelle-Caledonie, Reseau International Institut Pasteur, Noumea, New Caledonia.; UMR IRD 224-CNRS 5290-UM1-UM2, MIVEGEC, Institut de Recherche pour le Developpement, Noumea, New Caledonia.",,,,,,"BACKGROUND: The Pacific region is an area unique in the world, composed of thousands of islands with differing climates and environments. The spreading and establishment of the mosquito Aedes aegypti in these islands might be linked to human migration. Ae. aegypti is the major vector of arboviruses (dengue, chikungunya and Zika viruses) in the region. The intense circulation of these viruses in the Pacific during the last decade led to an increase of vector control measures by local health authorities. The aim of this study is to analyze the genetic relationships among Ae. aegypti populations in this region. METHODOLOGY/PRINCIPAL FINDING: We studied the genetic variability and population genetics of 270 Ae. aegypti, sampled from 9 locations in New Caledonia, Fiji, Tonga and French Polynesia by analyzing nine microsatellites and two mitochondrial DNA regions (CO1 and ND4). Microsatellite markers revealed heterogeneity in the genetic structure between the western, central and eastern Pacific island countries. The microsatellite markers indicate a statistically moderate differentiation (FST = 0.136; P < = 0.001) in relation to island isolation. A high degree of mixed ancestry can be observed in the most important towns (e.g. Noumea, Suva and Papeete) compared with the most isolated islands (e.g. Ouvea and Vaitahu). Phylogenetic analysis indicated that most of samples are related to Asian and American specimens. CONCLUSIONS/SIGNIFICANCE: Our results suggest a link between human migrations in the Pacific region and the origin of Ae. aegypti populations. The genetic pattern observed might be linked to the island isolation and to the different environmental conditions or ecosystems.",Pubmed,March 31, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Original research,No,Yes,286,Environmental and vector research,Ecological/animal cross-sectional
287,"Petersen, MMWR Morb Mortal Wkly Rep, 2016",Petersen,"Petersen, E. E.; Staples, J. E.; Meaney-Delman, D.; Fischer, M.; Ellington, S. R.; Callaghan, W. M.; Jamieson, D. J.","Interim Guidelines for Pregnant Women During a Zika Virus Outbreak - United States, 2016",MMWR Morb Mortal Wkly Rep,65,2,30. Mrz,2016,2010-present,January 23, 2016,26796813,10.15585/mmwr.mm6502e1,1331,English,http://www.ncbi.nlm.nih.gov/pubmed/26796813,,,,,,,"CDC has developed interim guidelines for health care providers in the United States caring for pregnant women during a Zika virus outbreak. These guidelines include recommendations for pregnant women considering travel to an area with Zika virus transmission and recommendations for screening, testing, and management of pregnant returning travelers. Updates on areas with ongoing Zika virus transmission are available online (http://wwwnc.cdc.gov/travel/notices/). Health care providers should ask all pregnant women about recent travel. Pregnant women with a history of travel to an area with Zika virus transmission and who report two or more symptoms consistent with Zika virus disease (acute onset of fever, maculopapular rash, arthralgia, or conjunctivitis) during or within 2 weeks of travel, or who have ultrasound findings of fetal microcephaly or intracranial calcifications, should be tested for Zika virus infection in consultation with their state or local health department. Testing is not indicated for women without a travel history to an area with Zika virus transmission. In pregnant women with laboratory evidence of Zika virus infection, serial ultrasound examination should be considered to monitor fetal growth and anatomy and referral to a maternal-fetal medicine or infectious disease specialist with expertise in pregnancy management is recommended. There is no specific antiviral treatment for Zika virus; supportive care is recommended.",Pubmed,March 31, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,No,Original research,No,Yes,287,Clinical/epidemiological research,Guidelines
288,"Dyer, BMJ, 2016",Dyer,"Dyer, O.",Jamaica advises women to avoid pregnancy as Zika virus approaches,BMJ,352,,i383,2016,2010-present,January 23, 2016,26796917,10.1136/bmj.i383,1330,English,http://www.ncbi.nlm.nih.gov/pubmed/26796917,Montreal.,,,,,,,Pubmed,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,News item or lay press,,,No,Yes,288,,
289,"Korhonen, Eurosurveillance, 2016",Korhonen,"Korhonen, E. M., Huhtamo, E., Smura, T., Kallio-Kokko, H., Raassina, M., Vapalahti, O.","Zika virus infection in a traveller returning from the Maldives, June 2015",Eurosurveillance,21,2,,2016,2010-present,January 23, 2016,26794427,10.2807/1560-7917.es.2016.21.2.30107,1332,English,,"Department of Virology, Medicum, Faculty of Medicine, University of Helsinki, Helsinki, Finland.",,,,,"Zika virus, emerging infectious diseases, flavivirus, mosquito-borne, traveller","We report a Zika virus (ZIKV) infection in a patient with fever and rash after returning to Finland from Maldives, June 2015. The patient had dengue virus (DENV) IgG and IgM antibodies but pan-flavivirus RT-PCR and subsequent sequencing showed presence of ZIKV RNA in urine. Recent association of ZIKV with microcephaly highlights the need for laboratory differentiation of ZIKV from DENV infection and the circulation of ZIKV in areas outside its currently known distribution range.",Pubmed,March 31, 2016,Yes,,No,"Zika, not relevant to causality framework",Scientific (journal) article,Yes,Original research,No,Yes,289,Clinical/epidemiological research,Case report
290,"Dyer, BMJ, 2016",Dyer,"Dyer, O.",Sixty seconds on . . . Zika virus,BMJ,352,,i467,2016,2010-present,January 28, 2016,26812929,10.1136/bmj.i467,1328,English,,Montreal.,,,,,,,Pubmed,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,News item or lay press,,,No,Yes,290,,
291,"Torjesen, BMJ, 2016",Torjesen,"Torjesen, I.",Zika virus outbreaks prompt warnings to pregnant women,BMJ,352,,i500,2016,2010-present,January 28, 2016,26813766,10.1136/bmj.i500,1327,English,,London.,,,,,,,Pubmed,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,News item or lay press,,,No,Yes,291,,
292,"Staples, MMWR Morb Mortal Wkly Rep, 2016",Staples,"Staples, J. E.; Dziuban, E. J.; Fischer, M.; Cragan, J. D.; Rasmussen, S. A.; Cannon, M. J.; Frey, M. T.; Renquist, C. M.; Lanciotti, R. S.; Munoz, J. L.; Powers, A. M.; Honein, M. A.; Moore, C. A.","Interim Guidelines for the Evaluation and Testing of Infants with Possible Congenital Zika Virus Infection - United States, 2016",MMWR Morb Mortal Wkly Rep,65,3,63-7,2016,2010-present,January 29, 2016,26820387,10.15585/mmwr.mm6503e3,1323,English,http://www.ncbi.nlm.nih.gov/pubmed/26820387,,,,,,,"CDC has developed interim guidelines for health care providers in the United States who are caring for infants born to mothers who traveled to or resided in an area with Zika virus transmission during pregnancy. These guidelines include recommendations for the testing and management of these infants. Guidance is subject to change as more information becomes available; the latest information, including answers to commonly asked questions, can be found online (http://www.cdc.gov/zika). Pediatric health care providers should work closely with obstetric providers to identify infants whose mothers were potentially infected with Zika virus during pregnancy (based on travel to or residence in an area with Zika virus transmission [http://wwwnc.cdc.gov/travel/notices]), and review fetal ultrasounds and maternal testing for Zika virus infection (see Interim Guidelines for Pregnant Women During a Zika Virus Outbreak*) (1). Zika virus testing is recommended for 1) infants with microcephaly or intracranial calcifications born to women who traveled to or resided in an area with Zika virus transmission while pregnant; or 2) infants born to mothers with positive or inconclusive test results for Zika virus infection. For infants with laboratory evidence of a possible congenital Zika virus infection, additional clinical evaluation and follow-up is recommended. Health care providers should contact their state or territorial health department to facilitate testing. As an arboviral disease, Zika virus disease is a nationally notifiable condition.",Pubmed,March 31, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,No,Original research,No,Yes,292,Clinical/epidemiological research,Guidelines
293,"Schuler-Faccini, MMWR Morb Mortal Wkly Rep, 2016",Schuler-Faccini,"Schuler-Faccini, L., Ribeiro, E. M., Feitosa, I. M., Horovitz, D. D., Cavalcanti, D. P., Pessoa, A., Doriqui, M. J., Neri, J. I., Neto, J. M., Wanderley, H. Y., Cernach, M., El-Husny, A. S., Pone, M. V., Serao, C. L., Sanseverino, M. T.","Possible Association Between Zika Virus Infection and Microcephaly - Brazil, 2015",MMWR Morb Mortal Wkly Rep,65,3,59-62,2016,2010-present,January 29, 2016,26820244,10.15585/mmwr.mm6503e2,1324,English,http://www.cdc.gov/mmwr/volumes/65/wr/mm6503e2.htm,"Universidade Federal do Rio Grande do Sul, Brazil  lavinia.faccini@ufrgs.br, 55-51-9975-6770",Brazil,Americas,Brazil,Not reported/unknown,,"In early 2015, an outbreak of Zika virus, a flavivirus trans- mitted by Aedes mosquitoes, was identified in northeast Brazil, an area where dengue virus was also circulating. By September, reports of an increase in the number of infants born with microcephaly in Zika virus-affected areas began to emerge, and Zika virus RNA was identified in the amniotic fluid of two women whose fetuses had been found to have microcephaly by prenatal ultrasound. The Brazil Ministry of Health (MoH) established a task force to investigate the possible association of microcephaly with Zika virus infection during pregnancy and a registry for incident microcephaly cases (head circumference ≥2 standard deviations [SD] below the mean for sex and ges- tational age at birth) and pregnancy outcomes among women suspected to have had Zika virus infection during pregnancy. Among a cohort of 35 infants with microcephaly born dur- ing August-October 2015 in eight of Brazil's 26 states and reported to the registry, the mothers of all 35 had lived in or visited Zika virus-affected areas during pregnancy, 25 (71%) infants had severe microcephaly (head circumference >3 SD below the mean for sex and gestational age), 17 (49%) had at least one neurologic abnormality, and among 27 infants who had neuroimaging studies, all had abnormalities.Tests for other congenital infections were negative. All infants had a lumbar puncture as part of the evaluation and cerebrospinal fluid (CSF) samples were sent to a reference laboratory in Brazil for Zika virus testing; results are not yet available. Further studies are needed to confirm the association of microcephaly with Zika virus infection during pregnancy and to understand any other adverse pregnancy outcomes associated with Zika virus infection. Pregnant women in Zika virus-affected areas should pro- tect themselves from mosquito bites by using air conditioning, screens, or nets when indoors, wearing long sleeves and pants, using permethrin-treated clothing and gear, and using insect repellents when outdoors. Pregnant and lactating women can use all U.S. Environmental Protection Agency (EPA)-registered insect repellents according to the product label.",Pubmed,March 31, 2016,Yes,,Yes,,Scientific (journal) article,No,Original research,No,Yes,293,Clinical/epidemiological research,Case series
294,"Lucey, JAMA, 2016",Lucey,"Lucey, D. R.; Gostin, L. O.",The Emerging Zika Pandemic: Enhancing Preparedness,JAMA,315,9,865-6,2016,2010-present,January 29, 2016,26818622,10.1001/jama.2016.0904,1326,English,http://www.ncbi.nlm.nih.gov/pubmed/26818622,"Georgetown University School of Medicine, Washington, DC.; O'Neill Institute for National and Global Health Law, Georgetown University Law Center, Washington, DC.",,,,,"Asymptomatic Infections/epidemiology; Capacity Building; Communicable Diseases, Emerging/epidemiology/*prevention & control; Disease Outbreaks; Emergencies; Humans; Microcephaly/virology; Mosquito Control; National Health Programs/organization & administration; Pandemics/*prevention & control; Population Surveillance; Travel; World Health Organization; *Zika Virus; Zika Virus Infection/epidemiology/*prevention & control",,Pubmed,March 31, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,294,,
295,"Hennessey, MMWR Morb Mortal Wkly Rep, 2016",Hennessey,"Hennessey, M., Fischer, M., Staples, J. E.","Zika Virus Spreads to New Areas - Region of the Americas, May 2015-January 2016",MMWR Morb Mortal Wkly Rep,65,3,55-8,2016,2010-present,January 29, 2016,26820163,10.15585/mmwr.mm6503e1,1325,English,,"Division of Vector-Borne Diseases, National Center for Emerging and Zoonotic Infectious Diseases, CDC.",,,,,,"Zika virus is a mosquito-borne flavivirus that was first identified in Uganda in 1947 (1). Before 2007, only sporadic human disease cases were reported from countries in Africa and Asia. In 2007, the first documented outbreak of Zika virus disease was reported in Yap State, Federated States of Micronesia; 73% of the population aged >/=3 years is estimated to have been infected (2). Subsequent outbreaks occurred in Southeast Asia and the Western Pacific (3). In May 2015, the World Health Organization reported the first local transmission of Zika virus in the Region of the Americas (Americas), with autochthonous cases identified in Brazil (4). In December, the Ministry of Health estimated that 440,000-1,300,000 suspected cases of Zika virus disease had occurred in Brazil in 2015 (5). By January 20, 2016, locally-transmitted cases had been reported to the Pan American Health Organization from Puerto Rico and 19 other countries or territories in the Americas* (Figure) (6). Further spread to other countries in the region is being monitored closely.",Pubmed,March 31, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,No,Comment/Editorial/Perspective/Letter,No,Yes,295,,
296,"Sow, Malar J, 2016",Sow,"Sow, A.; Loucoubar, C.; Diallo, D.; Faye, O.; Ndiaye, Y.; Senghor, C. S.; Dia, A. T.; Faye, O.; Weaver, S. C.; Diallo, M.; Malvy, D.; Sall, A. A.","Concurrent malaria and arbovirus infections in Kedougou, southeastern Senegal",Malar J,15,1,47,2016,2010-present,January 30, 2016,26821709,10.1186/s12936-016-1100-5,1322,English,http://www.ncbi.nlm.nih.gov/pubmed/26821709,"Arbovirus and Viral Hemorrhagic Fevers Unit, Institut Pasteur Dakar, 36 Avenue Pasteur, BP 220, Dakar, Senegal. asow@pasteur.sn.; Institut Sante et developpement (ISED), Universite Cheikh Anta Diop, Dakar, Senegal. asow@pasteur.sn.; Institut de Sante Publique d'Epidemiologie et de Developpement (ISPED), Centre de recherche INSERM U897 Epidemiologie-Biostatistique, Universite de Bordeaux, Bordeaux, France. asow@pasteur.sn.; Arbovirus and Viral Hemorrhagic Fevers Unit, Institut Pasteur Dakar, 36 Avenue Pasteur, BP 220, Dakar, Senegal. cloucoubar@pasteur.sn.; Medical Entomology Unit, Institut Pasteur Dakar, 36 Avenue Pasteur, BP 220, Dakar, Senegal. diawod@yahoo.fr.; Arbovirus and Viral Hemorrhagic Fevers Unit, Institut Pasteur Dakar, 36 Avenue Pasteur, BP 220, Dakar, Senegal. oumarfaye@pasteur.sn.; Saraya Health District, Saraya, Senegal. youndiaye@hotmail.com.; Kedougou Health District, Kedougou, Senegal. doczenghos@yahoo.fr.; Institut Sante et developpement (ISED), Universite Cheikh Anta Diop, Dakar, Senegal. adia@ised.sn.; Arbovirus and Viral Hemorrhagic Fevers Unit, Institut Pasteur Dakar, 36 Avenue Pasteur, BP 220, Dakar, Senegal. ofaye@pasteur.sn.; Department of Pathology, Institute for Human Infections and Immunity, Center for Tropical Diseases, University of Texas Medical Branch, Galveston, TX, USA. sweaver@utmb.edu.; Medical Entomology Unit, Institut Pasteur Dakar, 36 Avenue Pasteur, BP 220, Dakar, Senegal. diallo@pasteur.sn.; Institut de Sante Publique d'Epidemiologie et de Developpement (ISPED), Centre de recherche INSERM U897 Epidemiologie-Biostatistique, Universite de Bordeaux, Bordeaux, France. denis.malvy@chu-bordeaux.fr.; Arbovirus and Viral Hemorrhagic Fevers Unit, Institut Pasteur Dakar, 36 Avenue Pasteur, BP 220, Dakar, Senegal. asall@pasteur.sn.",,,,,,"BACKGROUND: Malaria is one of the leading causes of acute febrile illness (AFI) in Africa. With the advent of malaria rapid diagnostic tests, misdiagnosis and co-morbidity with other diseases has been highlighted by an increasing number of studies. Although arboviral infections and malaria are both vector-borne diseases and often have an overlapping geographic distribution in sub-Saharan Africa, information about their incidence rates and concurrent infections is scarce. METHODS: From July 2009 to March 2013 patients from seven healthcare facilities of the Kedougou region presenting with AFI were enrolled and tested for malaria and arboviral infections, i.e., yellow fever (YFV), West Nile (WNV), dengue (DENV), chikungunya (CHIKV), Crimean Congo haemorrhagic fever (CCHFV), Zika (ZIKV), and Rift Valley fever viruses (RVFV). Malaria parasite infections were investigated using thick blood smear (TBS) and rapid diagnostics tests (RDT) while arbovirus infections were tested by IgM antibody detection (ELISA) and RT-PCR assays. Data analysis of single or concurrent malaria and arbovirus was performed using R software. RESULTS: A total of 13,845 patients, including 7387 with malaria and 41 with acute arbovirus infections (12 YFV, nine ZIKV, 16 CHIKV, three DENV, and one RVFV) were enrolled. Among the arbovirus-infected patients, 48.7 % (20/41) were co-infected with malaria parasites at the following frequencies: CHIKV 18.7 % (3/16), YFV 58.3 % (7/12), ZIKV 88.9 % (8/9), DENV 33.3 % (1/3), and RVF 100 % (1/1). Fever >/=40 degrees C was the only sign or symptom significantly associated with dual malaria parasite/arbovirus infection. CONCLUSIONS: Concurrent malaria parasite and arbovirus infections were detected in the Kedougou region from 2009 to 2013 and need to be further documented, including among asymptomatic individuals, to assess its epidemiological and clinical impact.",Pubmed,March 31, 2016,Yes,,No,"Zika, indirect evidence or other topic",Scientific (journal) article,Yes,Original research,No,Yes,296,Clinical/epidemiological research,Cross-sectional study
297,"Higgs, Vector Borne Zoonotic Dis, 2016",Higgs,"Higgs, S.",Zika Virus: Emergence and Emergency,Vector Borne Zoonotic Dis,16,2,75-6,2016,2010-present,January 30, 2016,26824625,10.1089/vbz.2016.29001.hig,1321,English,,,,,,,,,Pubmed,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,297,,
298,"Gulland, BMJ, 2016",Gulland,"Gulland, A.",WHO urges countries in dengue belt to look out for Zika,BMJ,352,,i595,2016,2010-present,January 31, 2016,26825803,10.1136/bmj.i595,1320,English,,London.,,,,,,,Pubmed,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,News item or lay press,,,No,Yes,298,,
299,"Ruiz-Moreno, BMC Infect Dis, 2016",Ruiz-Moreno,"Ruiz-Moreno, D.",Assessing Chikungunya risk in a metropolitan area of Argentina through satellite images and mathematical models,BMC Infect Dis,16,1,49,2016,2010-present,February 3, 2016,26830024,10.1186/s12879-016-1348-y,1318,English,http://www.ncbi.nlm.nih.gov/pubmed/26830024,"Grupo de Ecologia Computacional, Instituto de Ciencias Sociales y Administracion, Universidad Nacional Arturo Jauretche, Florencio Varela, Buenos Aires, Argentina. diego.ruizmoreno.phd@gmail.com.",,,,,,"BACKGROUND: Chikungunya fever is a viral disease that recently invaded the American continent. In America, it is transmitted mainly by the mosquito Aedes aegypti, but Aedes albopictus is the main vector in other regions of the world. This work estimates the risk of disease emergence and the corresponding population at risk for the case of a naive population in the metropolitan area of Buenos Aires, the capital city of Argentina. METHODS: A classic metapopulation epidemiological model, that considers human and mosquito populations, was extended in order to include different environmental signals. First, the vital rates of the mosquitoes were affected by local temperature. Second, habitat availability estimated from satellite images was used to determine the carrying capacity for local mosquito populations. Disease invasion was proposed to occur at different moments of the year. For each scenario, Monte Carlo simulations were used to estimate the risk of disease invasion and the population at risk. RESULTS: The risk of a Chikungunya outbreak displays strong temporal (seasonal) patterns as well as spatial variability at the level of neighborhoods in the study area. According to the model, Summer and Fall display high risk for a Chikungunya invasion. The population at risk displays less variation over the year underlying the importance of preventive actions. CONCLUSIONS: The ability of mapping habitat quality for vector-borne diseases allows developing risk analysis at scales that are easily manageable for public health officers. For this location, the correlation of disease risk with the season of the year and the habitat availability could provide information to develop efficient control strategies. This also underlines the importance of involving the whole community when developing control measures for Chikungunya fever and other recently invading vector-borne diseases such as Zika fever.",Pubmed,March 31, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Original research,No,Yes,299,Clinical/epidemiological research,Modelling study
300,"Dyer, BMJ, 2016",Dyer,"Dyer, O.","Zika vaccine could be in production by year's end, says maker",BMJ,352,,i630,2016,2010-present,February 3, 2016,26829957,10.1136/bmj.i630,1319,English,,Montreal.,,,,,,,Pubmed,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,News item or lay press,,,No,Yes,300,,
301,"Chen, Ann Intern Med, 2016",Chen,"Chen, L. H., Hamer, D. H.",Zika Virus: Rapid Spread in the Western Hemisphere,Ann Intern Med,,,,2016,2010-present,February 3, 2016,26832396,10.7326/m16-0150,1317,English,,,,,,,,"Zika virus, a mosquito-borne flavivirus that causes febrile illness associated with rash, has been rapidly emerging in the Western Hemisphere over the past few months. The virus was rarely identified until outbreaks occurred on Yap Island in the Federated States of Micronesia in 2007, French Polynesia in 2013, and Easter Island in 2014. It was initially detected in Brazil in 2015, in the northeast, and was subsequently identified in other states and several South American countries, including Colombia, Ecuador, Suriname, Venezuela, French Guyana, and Paraguay (1). Local transmission has been documented in Central America (Panama, El Salvador, Honduras, and Guatemala), the Caribbean (Martinique, Puerto Rico, Dominican Republic, and Haiti), and Mexico. Transmission has also occurred in travelers returning from the infected regions to nonendemic countries, including the United States, Canada, Japan, and Western Europe. As of 22 January 2016, a total of 20 countries and territories in the Americas have Zika virus circulation (1). The explosive spread mirrors the emergence of chikungunya, which was first detected in the Americas (St. Martin) in 2013 and rapidly disseminated throughout the region (2).",Pubmed,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,301,,
302,"Ventura, Arq Bras Oftalmol, 2016",Ventura,"Ventura, C. V., Maia, M., Ventura, B. V., Linden, V. V., Araujo, E. B., Ramos, R. C., Rocha, M. A., Carvalho, M. D., Belfort, R., Jr., Ventura, L. O.",Ophthalmological findings in infants with microcephaly and presumable intra-uterus Zika virus infection,Arq Bras Oftalmol,79,1,01. Mrz,2016,2010-present,February 4, 2016,26840156,10.5935/0004-2749.20160002,1313,English,http://www.thelancet.com/pdfs/journals/lancet/PIIS0140-6736%2816%2900006-4.pdf,"Fundacao Altino Ventura, Recife, PE, Brazil., Department of Ophthalmology and Visual Sciences, Escola Paulista de Medicina, Universidade Federal de Sao Paulo, Sao Paulo, SP, Brazil., Hospital Barao de Lucena, Recife, PE, Brazil., Hospital Universitario Oswaldo Cruz, Recife, PE, Brazil.",Brazil,Americas,Brazil,No funding received,Microcephaly; Zika virus; Ocular findings; Vertical transmission; Retina,"PURPOSE: In 2015, a twenty-fold increase in the prevalence of microcephaly in Brazil was reported, and the Ministry of Health associated this abnormal prevalence with the maternal-fetal Zika virus (ZIKV) transmission. METHODS: We assessed the ophthalmological findings of ten mothers and their infants that had been clinically diagnosed with ZIKV-related microcephaly and presented ocular abnormalities, born from May to December 2015. RESULTS: Seven mothers (70.0%) referred symptoms during pregnancy (malaise, rash and arthralgia), of which six (85.7%) were in the first trimester. At the time of exam, no ophthalmological abnormalities were identified in the mothers and they did not report ocular symptoms during pregnancy. Serology was negative in all infants for Toxoplasmosis, Rubella, Cytomegalovirus, Syphilis and Human Immunodeficiency Viruses. Ocular findings included macular alterations (gross pigment mottling and/or chorioretinal atrophy) in fifteen eyes (75.0%), and optic nerve abnormalities (hypoplasia with double-ring sign, pallor, and/or increased cup-to-disk ratio) in nine eyes (45.0%). CONCLUSIONS: Patients presented normal anterior segment and important macular and optic nerve abnormalities. Further studies will assess the visual significance of these alterations.",Pubmed,March 31, 2016,Yes,,Yes,,Scientific (journal) article,Yes,Original research,Yes,No,1058,Clinical/epidemiological research,Case series
303,"Kmietowicz, BMJ, 2016",Kmietowicz,"Kmietowicz, Z.",Questions your patients may have about Zika virus,BMJ,352,,i649,2016,2010-present,February 4, 2016,26839177,10.1136/bmj.i649,1315,English,,The BMJ.,,,,,,,Pubmed,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,303,,
304,"Faccini-Martinez, J Infect Public Health, 2016",Faccini-Martinez,"Faccini-Martinez, A. A., Botero-Garcia, C. A., Benitez-Baracaldo, F. C., Perez-Diaz, C. E.","With regard about the case of Dengue, Chikungunya and Zika co-infection in a patient from Colombia",J Infect Public Health,,,,2016,2010-present,February 4, 2016,26837723,10.1016/j.jiph.2016.01.001,1316,English,,"Servicios y Asesorias en Infectologia, Bogota, Colombia. Electronic address: afaccini@gmail.com., School of Medicine, Universidad Militar Nueva Granada, Bogota, Colombia., Servicios y Asesorias en Infectologia, Bogota, Colombia., Servicios y Asesorias en Infectologia, Bogota, Colombia; Infectious Diseases Department, Clinica de Marly, Bogota, Colombia.",,,,,,,Pubmed,March 31, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,No,Comment/Editorial/Perspective/Letter,No,Yes,304,,
305,"Gulland, BMJ, 2016",Gulland,"Gulland, A.","Zika virus is a global public health emergency, declares WHO",BMJ,352,,i657,2016,2010-present,February 4, 2016,26839247,10.1136/bmj.i657,1314,English,,London.,,,,,,,Pubmed,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,News item or lay press,,,No,Yes,305,,
306,"Fontes, Arq Bras Oftalmol, 2016",Fontes,"Fontes, B. M.",Zika virus-related hypertensive iridocyclitis,Arq Bras Oftalmol,79,1,63,2016,2010-present,February 4, 2016,26840174,10.5935/0004-2749.20160020,1312,English,http://www.ncbi.nlm.nih.gov/pubmed/26840174,"Centro de Microcirurgia & Diagnostico, Rio de Janeiro, RJ, Brazil.",Brazil,Americas,,Other,,The epidemic of Zika virus infection in Brazil has lead to the description of new complications and manifestations such as Guillain-Barré syndrome in adults and microcephaly in newborns.  The purpose of this letter is to describe a case of bilateral hypertensiveiridocyclitis attributed to Zika virus in an otherwise healthy young male.,Pubmed,March 31, 2016,Yes,,No,"Zika, indirect evidence or other topic",Scientific (journal) article,Unknown/unclear,Original research,No,Yes,306,Clinical/epidemiological research,Case report
307,"O'Dowd, BMJ, 2016",O'Dowd,"O'Dowd, A.","UK is safe from Zika virus and is helping towards a vaccine, MPs hear",BMJ,352,,i692,2016,2010-present,February 5, 2016,26842604,10.1136/bmj.i692,1310,English,,London.,,,,,,,Pubmed,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,News item or lay press,,,No,Yes,307,,
308,"The Lancet, Lancet, 2016",The Lancet,The Lancet,Zika virus: a new global threat for 2016,Lancet,387,10014,96,2016,2010-present,February 5, 2016,26841979,10.1016/S0140-6736(16)00014-3,1311,English,http://www.ncbi.nlm.nih.gov/pubmed/26841979,,,,,,"Communicable Diseases, Emerging/*epidemiology/transmission/virology; Female; Fetal Diseases/epidemiology/virology; Global Health; Humans; Microcephaly/epidemiology/virology; *Pandemics; Pregnancy; Zika Virus/*pathogenicity; Zika Virus Infection/*epidemiology/transmission/virology",,Pubmed,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,308,,
309,"The Lancet, Nature, 2016",The Lancet,The Lancet,The next steps on Zika,Nature,530,7588,5,2016,2010-present,February 6, 2016,26842018,10.1038/530005a,1309,English,http://www.ncbi.nlm.nih.gov/pubmed/26842018,,,,,,"Aedes/*virology; Animals; Brazil/epidemiology; Female; Humans; Infectious Disease Transmission, Vertical/prevention & control/statistics &; numerical data; Microcephaly/epidemiology/etiology/virology; Mosquito Control/*methods; Pregnancy; Pregnancy Complications, Infectious/epidemiology/prevention & control/virology; Rubella/epidemiology; Tropical Climate; Virology/*trends; Zika Virus/isolation & purification/*pathogenicity; Zika Virus Infection/*epidemiology/prevention & control/virology",,Pubmed,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,309,,
310,"Yakob, Lancet Glob Health, 2016",Yakob,"Yakob, L.; Walker, T.",Zika virus outbreak in the Americas: the need for novel mosquito control methods,Lancet Glob Health,4,3,e148-9,2016,2010-present,February 6, 2016,26848089,10.1016/S2214-109X(16)00048-6,1306,English,http://www.ncbi.nlm.nih.gov/pubmed/26848089,"Department of Disease Control, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK. Electronic address: laith.yakob@lshtm.ac.uk.; Department of Disease Control, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK.",,,,,,"Local transmission of Zika virus (ZIKV) in the Americas was first confirmed in February, 2014, on Easter Island. In May, 2015, 16 patients from the Brazilian states of Bahia and Rio Grande do Norte were found to be ZIKV-positive. 22 countries and territories have subsequently identified autochthonous transmission within the region (figure). Until recently, ZIKV infection was only associated with mild symptoms (headache, rash, joint pain, conjunctivitis) but a possible link between ZIKV infection during pregnancy and subsequent birth defects (most notably microcephaly) was identified in November, 2015.",Pubmed,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,310,,
311,"McCarthy, BMJ, 2016",McCarthy,"McCarthy, M.","Zika virus was transmitted by sexual contact in Texas, health officials report",BMJ,352,,i720,2016,2010-present,February 6, 2016,26848011,10.1136/bmj.i720,1307,English,,Seattle.,,,,,,,Pubmed,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,News item or lay press,,,No,Yes,311,,
312,"Butler, Nature, 2016",Butler,"Butler, D.",Zika virus: Brazil's surge in small-headed babies questioned by report,Nature,530,7588,13. Apr,2016,2010-present,February 6, 2016,26842033,10.1038/nature.2016.19259,1308,English,,,,,,,"Brazil/epidemiology, Diagnostic Errors/*statistics & numerical data, Female, Humans, Infectious Disease Transmission, Vertical/statistics & numerical data, Microcephaly/*diagnosis/*epidemiology/etiology/virology, Pregnancy, *Uncertainty, Zika Virus/isolation & purification/*pathogenicity, Zika Virus Infection/*epidemiology/transmission/virology",,Pubmed,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,News item or lay press,,,No,Yes,312,,
313,"Paz, Lancet, 2016",Paz,"Paz, S.; Semenza, J. C.",El Nino and climate change--contributing factors in the dispersal of Zika virus in the Americas?,Lancet,387,10020,745,2016,2010-present,February 7, 2016,26850984,10.1016/S0140-6736(16)00256-7,1302,English,http://www.ncbi.nlm.nih.gov/pubmed/26850984,"Department of Geography and Environmental Studies, University of Haifa, Mt Carmel, Haifa, 3498838, Israel. Electronic address: shlomit@geo.haifa.ac.il.; Stockholm Environmental Institute, Stockholm, Sweden.",,,,,Animals; Humans; *Pandemics; *Travel; Zika Virus Infection/*epidemiology/*transmission,"In their letter, Isaac I Bogoch and colleagues (Jan 23, p 335)1 anticipated the international spread of Zika virus from Brazil through air traffic. Permissive climatic conditions for Aedes mosquitoes might have contributed to the explosive spread of Zika virus in Brazil. In fact, the 2015 El Niño caused exceptional climatic conditions in northeastern South America during winter and spring in the southern hemisphere. According to the US National Oceanic and Atmospheric Administration,2 the temperatures over north and eastern South America were 'record warmest', accompanied by a severe drought, throughout the second half of 2015.",Pubmed,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,No,Comment/Editorial/Perspective/Letter,No,Yes,313,,
314,"Gulland, BMJ, 2016",Gulland,"Gulland, A.",WHO warns European countries to be on alert for Zika,BMJ,352,,i753,2016,2010-present,February 7, 2016,26849896,10.1136/bmj.i753,1303,English,,London.,,,,,,,Pubmed,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,News item or lay press,,,No,Yes,314,,
315,"Samarasekera, Lancet, 2016",Samarasekera,"Samarasekera, U.; Triunfol, M.",Concern over Zika virus grips the world,Lancet,387,10018,521-4,2016,2010-present,February 8, 2016,26852261,10.1016/S0140-6736(16)00257-9,1301,English,http://www.ncbi.nlm.nih.gov/pubmed/26852261,,,,,,"Biomedical Research; Central Nervous System Viral Diseases/epidemiology/prevention & control; Communicable Diseases, Emerging/epidemiology/prevention & control; Disease Outbreaks/*prevention & control; Global Health/statistics & numerical data; Humans; Microcephaly/epidemiology/prevention & control/virology; Risk Factors; Viral Vaccines; World Health Organization; Zika Virus/immunology; Zika Virus Infection/*prevention & control",,Pubmed,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,315,,
316,"Ayres, Lancet Infect Dis, 2016",Ayres,"Ayres, C. F.",Identification of Zika virus vectors and implications for control,Lancet Infect Dis,16,3,278-9,2016,2010-present,February 9, 2016,26852727,10.1016/S1473-3099(16)00073-6,1300,English,http://www.ncbi.nlm.nih.gov/pubmed/26852727,"Centro de Pesquisas Aggeu Magalhaes, Fundacao Oswaldo Cruz, Campus da UFPE, Cidade Universitaria, Recife-PE, Brazil. Electronic address: tans@cpqam.fiocruz.br.",,,,,,"Zika virus is an emerging pathogen that has recently been causing serious epidemics around the world. Cases of Zika virus disease were reported in Micronesia in 20071 and then in French Polynesia in 2013.2 In French Polynesia, Guillain-Barré syndrome was reported for the first time in a few patients following Zika virus infection. In Brazil, Zika virus was introduced in 2014,3 and was subsequently associated with cases of microcephaly. So far, an estimated minimum of 400 000 cases of Zika virus disease have been reported in 24 states in Brazil, although the number of cases could be far higher.",Pubmed,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,316,,
317,"Petersen, Int J Infect Dis, 2016",Petersen,"Petersen, E., Wilson, M. E., Touch, S., McCloskey, B., Mwaba, P., Bates, M., Dar, O., Mattes, F., Kidd, M., Ippolito, G., Azhar, E. I., Zumla, A.",Rapid Spread of Zika Virus in The Americas - Implications for Public Health Preparedness for Mass Gatherings at the 2016 Brazil Olympic Games,Int J Infect Dis,44,,11. Mai,2016,2010-present,February 9, 2016,26854199,10.1016/j.ijid.2016.02.001,1299,English,,"The Royal Hospital, Muscat, Oman, and Insititute of Clinical Medicine, Aarhus University, Aarhus, Denmark. Electronic address: eskildp@dadlnet.dk., School of Medicine, University of California, San Francisco, USA; Harvard T.H. Chan School of Public Health, Boston, MA, USA., Communicable Disease Control Department, Ministry of Health, Cambodia., Global Health Department, Public Health England, London, United Kingdom., UNZA-UCLMS Project, University Teaching Hospital, and Ministry of Health, Lusaka, Zambia., Dept of Virology, University College London Hospitals NHS Foundation Trust, London, UK., National Institute for Infectious Diseases Lazzaro Spallanzani, Rome, Italy., Special Infectious Agents Unit, King Fahd Medical Research Centre, and Medical Laboratory Technology Department, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia., Special Infectious Agents Unit, King Fahd Medical Research Centre, and Medical Laboratory Technology Department, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia; Division of Infection and Immunity, University College London, and NIHR Biomedical Research Centre, UCL Hospitals NHS Foundation Trust, London, United Kingdom.",,,,,"Arboviruses, Brazil, Mass Gatherings, Olympics, Sporting events, Zika virus","Mass gatherings at major international sporting events put millions of international travelers and local host-country residents at risk of acquiring infectious diseases, including locally endemic infectious diseases. The mosquito-borne Zika virus (ZIKV) has recently aroused global attention due to its rapid spread since its first detection in May 2015 in Brazil to 22 other countries and other territories in the Americas. The ZIKV outbreak in Brazil, has also been associated with a significant rise in the number of babies born with microcephaly and neurological disorders, and has been declared a 'Global Emergency by the World Health Organization. This explosive spread of ZIKV in Brazil poses challenges for public health preparedness and surveillance for the Olympics and Paralympics which are due to be held in Rio De Janeiro in August, 2016. We review the epidemiology and clinical features of the current ZIKV outbreak in Brazil, highlight knowledge gaps, and review the public health implications of the current ZIKV outbreak in the Americas. We highlight the urgent need for a coordinated collaborative response for prevention and spread of infectious diseases with epidemic potential at mass gatherings events.",Pubmed,March 31, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Yes,Review,No,Yes,317,Clinical/epidemiological research,Epidemiological/clinical review
318,"McCarthy, BMJ, 2016",McCarthy,"McCarthy, M.",CDC updates Zika virus guidance to protect pregnant women,BMJ,352,,i786,2016,2010-present,February 10, 2016,26858259,10.1136/bmj.i786,1296,English,http://www.ncbi.nlm.nih.gov/pubmed/26858259,Seattle.,,,,,,,Pubmed,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,News item or lay press,,,No,Yes,318,,
319,"Gyurech, Swiss Med Wkly, 2016",Gyurech,"Gyurech, D.; Schilling, J.; Schmidt-Chanasit, J.; Cassinotti, P.; Kaeppeli, F.; Dobec, M.",False positive dengue NS1 antigen test in a traveller with an acute Zika virus infection imported into Switzerland,Swiss Med Wkly,146,,w14296,2016,2010-present,February 10, 2016,26859285,10.4414/smw.2016.14296,1294,English,http://www.ncbi.nlm.nih.gov/pubmed/26859285,"Travel Clinic, Zurich, Switzerland.; Bernhard Nocht Institute for Tropical Medicine/World Health Organization Collaborating Centre for Arbovirus and Haemorrhagic Fever Reference and Research, Hamburg, Germany; German Centre for Infection Research (DZIF), Hamburg-Lubeck-Borstel, Hamburg, Ger.; medica, medizinische Laboratorien Dr. F. Kaeppeli, Zurich, Switzerland.",,,,,,"We report the first case of an acute Zika virus infection imported into Switzerland by a traveller returning from Canoa Quebrada, Ceará state, in the north-eastern part of Brazil. Due to a false positive dengue virus NS1 antigen test, IgG-antibody seroconversion and a suggestive clinical picture, an acute dengue fever was initially considered. However, because of lack of specific IgM-antibodies, stationary IgG-antibody titre and a negative dengue virus PCR test result, a dengue virus infection was excluded and a cross-reaction with other, causative flaviviruses was postulated. Based on recent reports of Zika fever cases in the north-eastern parts of Brazil, an acute Zika virus infection was suspected. Because of a lack of commercially available Zika virus diagnostic tests, the case was confirmed in the WHO reference laboratory. As the clinical presentation of Zika virus infection can be confused with dengue fever and chikungunya fever, and because of possible public health implications, all patients returning from affected areas should be additionally tested for Zika virus. This case illustrates the urgent medical need for a broadly available assay capable of differentiating Zika from Dengue infections.",Pubmed,March 31, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Original research,No,Yes,319,Clinical/epidemiological research,Case report
320,"Kampango, Parasit Vectors, 2016",Kampango,"Kampango, A.; Abilio, A. P.","The Asian tiger hunts in Maputo city-the first confirmed report of Aedes (Stegomyia) albopictus (Skuse, 1895) in Mozambique",Parasit Vectors,9,1,76,2016,2010-present,February 10, 2016,26856329,10.1186/s13071-016-1361-4,1298,English,http://www.ncbi.nlm.nih.gov/pubmed/26856329,"Laboratorio de Entomologia, Instituto Nacional de Saude (INS), Av. Eduardo Mondlane / Allende, n masculine 1008, C.P. 246, Maputo, Mozambique. akampango@gmail.com.; Laboratorio de Entomologia, Instituto Nacional de Saude (INS), Av. Eduardo Mondlane / Allende, n masculine 1008, C.P. 246, Maputo, Mozambique. anabilio1408@gmail.com.",,,,,,"BACKGROUND: Increasing evidence suggests that dengue fever is endemic in Mozambique. Larvae of both the Afrotropical vector Aedes aegypti and its subspecies, Ae. aegypti formosus, have been reported from three provinces in Mozambique, two of which recently experienced dengue outbreaks. Despite reports of the invasive Oriental vector Ae. albopictus on the islands in the Mozambique Channel and nearby Indian Ocean, the species has not yet been reported in Mozambique. FINDINGS: Four host-seeking female mosquitoes, collected biting the authors in an urban neighbourhood of Maputo City in the late afternoon of 6 December, 2015, are herein morphologically confirmed as Ae. albopictus. CONCLUSION: This is the first report confirming the occurrence in Mozambique of Ae. albopictus, an invasive species and an important vector of human arboviruses. In view of its potential role as a vector of dengue, Chikungunya and Zika viruses, studies are urgently needed to assess the geographical expansion and relative abundance of these important vectors to better understand the potential transmission impact of arboviruses that are efficiently transmitted and globally spread by these vectors.",Pubmed,March 31, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Original research,No,Yes,320,Environmental and vector research,Ecological/animal cross-sectional
321,"Lucey, BMJ, 2016",Lucey,"Lucey, D. R.",Time for global action on Zika virus epidemic,BMJ,352,,i781,2016,2010-present,February 10, 2016,26856896,10.1136/bmj.i781,1297,English,,"Department of Medicine, Infectious Diseases, Georgetown University Medical Center, Washington, DC, USA DRL23@Georgetown.edu.",,,,,,,Pubmed,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,321,,
322,"MacFadden, Cmaj, 2016",MacFadden,"MacFadden, D. R., Bogoch,, II",Zika virus infection,Cmaj,188,5,367,2016,2010-present,February 10, 2016,26858352,10.1503/cmaj.151486,1295,English,,"Division of Infectious Diseases (MacFadden, Bogoch), University of Toronto, Toronto, Ont.; Harvard T.H. Chan School of Public Health (MacFadden), Harvard University, Boston, Mass. derek.macfadden@mail.utoronto.ca., Division of Infectious Diseases (MacFadden, Bogoch), University of Toronto, Toronto, Ont.; Harvard T.H. Chan School of Public Health (MacFadden), Harvard University, Boston, Mass.",,,,,,,Pubmed,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,322,,
323,"[No authors listed], Nurs Stand, 2016",[No authors listed],[No authors listed],Healthcare staff encouraged to warn patients of the risks of the Zika virus,Nurs Stand,30,24,9,2016,2010-present,February 11, 2016,26860137,10.7748/ns.30.24.9.s7,1293,English,http://www.ncbi.nlm.nih.gov/pubmed/26860137,,,,,,,Healthcare workers in primary care should inform pregnant women of the risks associated with the Zika virus if they are travelling to affected countries.,Pubmed,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,News item or lay press,,,No,Yes,323,,
324,"[No authors listed], Nurs Stand, 2016",[No authors listed],[No authors listed],Zika virus,Nurs Stand,30,24,17,2016,2010-present,February 11, 2016,26860150,10.7748/ns.30.24.17.s20,1292,English,http://www.ncbi.nlm.nih.gov/pubmed/26860150,,,,,,,"Essential facts Zika virus disease is caused by a virus that is transmitted by the Aedes mosquito. While it generally causes a mild illness, there is increasing concern that it is harmful in pregnancy and can cause congenital abnormalities in infants born to women infected with the virus. There is no antiviral treatment or vaccine currently available. The best form of prevention is protection against mosquito bites.",Pubmed,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,No,Comment/Editorial/Perspective/Letter,No,Yes,324,,
325,"Rubin, N Engl J Med, 2016",Rubin,"Rubin, E. J., Greene, M. F., Baden, L. R.",Zika Virus and Microcephaly,N Engl J Med,374,10,984-5,2016,2010-present,February 11, 2016,26862812,10.1056/NEJMe1601862,1291,English,,"From the Department of Immunology and Infectious Diseases, Harvard School of Public Health (E.J.R.), and the Department of Obstetrics and Gynecology, Massachusetts General Hospital (M.F.G.) - both in Boston.",,,,,"Brain/*pathology, Female, Fetal Diseases/*pathology, Humans, Microcephaly/*virology, Pregnancy, Zika Virus/*genetics, Zika Virus Infection/*pathology",,Pubmed,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,No,Comment/Editorial/Perspective/Letter,No,Yes,325,,
326,"Mlakar, N Engl J Med, 2016",Mlakar,"Mlakar, J., Korva, M., Tul, N., Popovic, M., Poljsak-Prijatelj, M., Mraz, J., Kolenc, M., Resman Rus, K., Vesnaver Vipotnik, T., Fabjan Vodusek, V., Vizjak, A., Pizem, J., Petrovec, M., Avsic Zupanc, T.",Zika Virus Associated with Microcephaly,N Engl J Med,374,10,951-8,2016,2010-present,February 11, 2016,26862926,10.1056/NEJMoa1600651,1290,English,http://www.nejm.org/doi/pdf/10.1056/NEJMoa1600651,"Institute of Microbiology and Im- munology, Faculty of Medicine, Univer- sity of Ljubljana, Zaloška 4, Ljubljana 1000, Slovenia,orattatjana.avsic@mf.uni-lj.si",Slovenia,Europe,Slovenia,Not reported/unknown,"Abortion, Therapeutic, Adult, Brain/embryology/*pathology/virology, Female, Fetal Diseases/*pathology/ultrasonography/virology, Genome, Viral, Humans, Infectious Disease Transmission, Vertical, Microcephaly/pathology/ultrasonography/*virology, Phylogeny, Pregnancy, Pregnancy Trimester, Third, Reverse Transcriptase Polymerase Chain Reaction, Ultrasonography, Prenatal, Zika Virus/*genetics/isolation & purification, Zika Virus Infection/complications/*pathology/transmission","A widespread epidemic of Zika virus (ZIKV) infection was reported in 2015 in South and Central America and the Caribbean. A major concern associated with this infection is the apparent increased incidence of microcephaly in fetuses born to mothers infected with ZIKV. In this report, we describe the case of an expectant mother who had a febrile illness with rash at the end of the first trimester of pregnancy while she was living in Brazil. Ultrasonography performed at 29 weeks of gestation revealed microcephaly with calcifications in the fetal brain and placenta. After the mother requested termination of the pregnancy, a fetal autopsy was performed. Micrencephaly (an abnormally small brain) was observed, with almost complete agyria, hydrocephalus, and multifocal dystrophic calcifications in the cortex and subcortical white matter, with associated cortical displacement and mild focal inflammation. ZIKV was found in the fetal brain tissue on reverse-transcriptase-polymerase-chain-reaction (RT-PCR) assay, with consistent findings on electron microscopy. The complete genome of ZIKV was recovered from the fetal brain.",Pubmed,March 31, 2016,Yes,,Yes,,Scientific (journal) article,Yes,Original research,No,Yes,326,Clinical/epidemiological research,Case report
327,"Elachola, Lancet, 2016",Elachola,"Elachola, H.; Gozzer, E.; Zhuo, J.; Memish, Z. A.","A crucial time for public health preparedness: Zika virus and the 2016 Olympics, Umrah, and Hajj",Lancet,387,10019,630-2,2016,2010-present,February 13, 2016,26864962,10.1016/S0140-6736(16)00274-9,1285,English,http://www.ncbi.nlm.nih.gov/pubmed/26864962,"Atlanta, Georgia, USA.; Instituto Nacional de Salud, Lima, Peru.; Guangxi Centers for Disease Control and Prevention, Guangxi, China.; Ministry of Health, Riyadh, Saudi Arabia; College of Medicine, Alfaisal University, Riyadh 11514, Saudi Arabia. Electronic address: zmemish@yahoo.com.",,,,,"Americas/epidemiology; Brazil/epidemiology; Central Nervous System Viral Diseases/epidemiology/prevention & control; Ceremonial Behavior; Disease Outbreaks; Female; Humans; Islam; Microcephaly/epidemiology/prevention & control; Pregnancy; Pregnancy Complications, Infectious/epidemiology/prevention & control; Public Health; Saudi Arabia; Sports; Travel; Zika Virus Infection/*epidemiology/prevention & control",,Pubmed,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,No,Comment/Editorial/Perspective/Letter,No,Yes,327,,
328,"[No authors listed], Nature, 2016",[No authors listed],[No authors listed],Benefits of sharing,Nature,530,7589,129,2016,2010-present,February 13, 2016,26863943,10.1038/530129a,1289,English,http://www.ncbi.nlm.nih.gov/pubmed/26863943,,,,,,"Brazil/epidemiology; Databases, Factual/utilization; Disease Outbreaks/statistics & numerical data; Evidence-Based Medicine; Humans; *Information Dissemination; Microcephaly/*epidemiology/etiology/virology; *Open Access Publishing; Sequence Analysis, DNA; Time Factors; World Health Organization; *Zika Virus/genetics/pathogenicity; Zika Virus Infection/*epidemiology/virology",,Pubmed,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,No,Comment/Editorial/Perspective/Letter,No,Yes,328,,
329,"Oster, MMWR Morb Mortal Wkly Rep, 2016",Oster,"Oster, A. M.; Brooks, J. T.; Stryker, J. E.; Kachur, R. E.; Mead, P.; Pesik, N. T.; Petersen, L. R.","Interim Guidelines for Prevention of Sexual Transmission of Zika Virus - United States, 2016",MMWR Morb Mortal Wkly Rep,65,5,120-1,2016,2010-present,February 13, 2016,26866485,10.15585/mmwr.mm6505e1,1282,English,http://www.ncbi.nlm.nih.gov/pubmed/26866485,,,,,,,"Zika virus is a mosquito-borne flavivirus primarily transmitted by Aedes aegypti mosquitoes (1,2). Infection with Zika virus is asymptomatic in an estimated 80% of cases (2,3), and when Zika virus does cause illness, symptoms are generally mild and self-limited. Recent evidence suggests a possible association between maternal Zika virus infection and adverse fetal outcomes, such as congenital microcephaly (4,5), as well as a possible association with Guillain-Barre syndrome. Currently, no vaccine or medication exists to prevent or treat Zika virus infection. Persons residing in or traveling to areas of active Zika virus transmission should take steps to prevent Zika virus infection through prevention of mosquito bites (http://www.cdc.gov/zika/prevention/).",Pubmed,March 31, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,No,Original research,No,Yes,329,Clinical/epidemiological research,Guidelines
330,"de Paula Freitas, JAMA Ophthalmol, 2016",de Paula Freitas,"de Paula Freitas, B.; de Oliveira Dias, J. R.; Prazeres, J.; Sacramento, G. A.; Ko, A. I.; Maia, M.; Belfort, R., Jr.","Ocular Findings in Infants With Microcephaly Associated With Presumed Zika Virus Congenital Infection in Salvador, Brazil",JAMA Ophthalmol,,,,2016,2010-present,February 9, 2016,26865554,10.1001/jamaophthalmol.2016.0267,1283,English,http://www.ncbi.nlm.nih.gov/pubmed/26865554,"Vision Institute, Department of Ophthalmology, Paulista Medical School, Federal University of São Paulo,  Rua Botucatu, 822, São Paulo 04023-062, Brazil, clinbelf@uol.com.br",Brazil,Americas,Brazil,Mixed,,"Importance: The Zika virus (ZIKV) has rapidly reached epidemic proportions, especially in northeastern Brazil, and has rapidly spread to other parts of the Americas. A recent increase in the prevalence of microcephaly in newborn infants and vision-threatening findings in these infants is likely associated with the rapid spread of ZIKV. Objective: To evaluate the ocular findings in infants with microcephaly associated with presumed intrauterine ZIKV infection in Salvador, Bahia, Brazil. Design, Setting, and Participants: Case series at a tertiary hospital. Twenty-nine infants with microcephaly (defined by a cephalic circumference of </=32 cm) with a presumed diagnosis of congenital ZIKV were recruited through an active search and referrals from other hospitals and health unities. The study was conducted between December 1 and December 21, 2015. Interventions: All infants and mothers underwent systemic and ophthalmic examinations from December 1 through December 21, 2015, in the Roberto Santos General Hospital, Salvador, Brazil. Anterior segment and retinal, choroidal, and optic nerve abnormalities were documented using a wide-field digital imaging system. The differential diagnosis included toxoplasmosis, rubella, cytomegalovirus, herpes simplex virus, syphilis, and human immunodeficiency virus, which were ruled out through serologic and clinical examinations. Main Outcomes and Measures: Ocular abnormalities associated with ZIKV. Results: Twenty-three of 29 mothers (79.3%) reported suspected ZIKV infection signs and symptoms during pregnancy, 18 in the first trimester, 4 in the second trimester, and 1 in the third trimester. Of the 29 infants (58 eyes) examined (18 [62.1%] female), ocular abnormalities were present in 17 eyes (29.3%) of 10 children (34.5%). Bilateral findings were found in 7 of 10 patients presenting with ocular lesions, the most common of which were focal pigment mottling of the retina and chorioretinal atrophy in 11 of the 17 eyes with abnormalities (64.7%), followed by optic nerve abnormalities in 8 eyes (47.1%), bilateral iris coloboma in 1 patient (2 eyes [11.8%]), and lens subluxation in 1 eye (5.9%). Conclusions and Relevance: Congenital infection due to presumed ZIKV exposure is associated with vision-threatening findings, which include bilateral macular and perimacular lesions as well as optic nerve abnormalities in most cases.",Pubmed,March 31, 2016,Yes,,Yes,,Scientific (journal) article,Yes,Original research,No,Yes,330,Clinical/epidemiological research,Case series
331,"Check Hayden, Nature, 2016",Check Hayden,"Check Hayden, E.",Proving Zika link to birth defects poses huge challenge,Nature,530,7589,142-3,2016,2010-present,February 13, 2016,26863963,10.1038/530142a,1288,English,,,,,,,"Animals, Antibodies, Viral/analysis/immunology, Biomedical Research/*trends, Brazil/epidemiology, Case-Control Studies, Disease Models, Animal, *Evidence-Based Medicine, Female, Fetal Diseases/epidemiology/etiology/virology, Humans, Infant, Newborn, Infant, Newborn, Diseases/epidemiology/etiology/virology, Infectious Disease Transmission, Vertical, Microcephaly/epidemiology/*etiology/pathology/*virology, Pregnancy, Time Factors, Zika Virus/genetics/immunology/isolation & purification/*pathogenicity, Zika Virus Infection/*complications/diagnosis/epidemiology/*virology",,Pubmed,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,News item or lay press,,,No,Yes,331,,
332,"Kmietowicz, BMJ, 2016",Kmietowicz,"Kmietowicz, Z.",Research bodies vow to share data on Zika,BMJ,352,,i877,2016,2010-present,February 13, 2016,26868414,10.1136/bmj.i877,1280,English,,The BMJ.,,,,,,,Pubmed,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,News item or lay press,,,No,Yes,332,,
333,"McCarthy, BMJ, 2016",McCarthy,"McCarthy, M.",Severe eye damage in infants with microcephaly is presumed to be due to Zika virus,BMJ,352,,i855,2016,2010-present,February 13, 2016,26864344,10.1136/bmj.i855,1286,English,,Seattle.,,,,,,,Pubmed,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,News item or lay press,,,No,Yes,333,,
334,"O'Dowd, BMJ, 2016",O'Dowd,"O'Dowd, A.",UK records four cases of Zika virus in past six weeks,BMJ,352,,i875,2016,2010-present,February 13, 2016,26868672,10.1136/bmj.i875,1279,English,,London.,,,,,,,Pubmed,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,News item or lay press,,,No,Yes,334,,
335,"Oduyebo, MMWR Morb Mortal Wkly Rep, 2016",Oduyebo,"Oduyebo, T., Petersen, E. E., Rasmussen, S. A., Mead, P. S., Meaney-Delman, D., Renquist, C. M., Ellington, S. R., Fischer, M., Staples, J. E., Powers, A. M., Villanueva, J., Galang, R. R., Dieke, A., Munoz, J. L., Honein, M. A., Jamieson, D. J.","Update: Interim Guidelines for Health Care Providers Caring for Pregnant Women and Women of Reproductive Age with Possible Zika Virus Exposure - United States, 2016",MMWR Morb Mortal Wkly Rep,65,5,122-7,2016,2010-present,February 13, 2016,26866840,10.15585/mmwr.mm6505e2,1281,English,,,,,,,,"CDC has updated its interim guidelines for U.S. health care providers caring for pregnant women during a Zika virus outbreak (1). Updated guidelines include a new recommendation to offer serologic testing to asymptomatic pregnant women (women who do not report clinical illness consistent with Zika virus disease) who have traveled to areas with ongoing Zika virus transmission. Testing can be offered 2-12 weeks after pregnant women return from travel. This update also expands guidance to women who reside in areas with ongoing Zika virus transmission, and includes recommendations for screening, testing, and management of pregnant women and recommendations for counseling women of reproductive age (15-44 years). Pregnant women who reside in areas with ongoing Zika virus transmission have an ongoing risk for infection throughout their pregnancy. For pregnant women with clinical illness consistent with Zika virus disease,* testing is recommended during the first week of illness. For asymptomatic pregnant women residing in areas with ongoing Zika virus transmission, testing is recommended at the initiation of prenatal care with follow-up testing mid-second trimester. Local health officials should determine when to implement testing of asymptomatic pregnant women based on information about levels of Zika virus transmission and laboratory capacity. Health care providers should discuss reproductive life plans, including pregnancy intention and timing, with women of reproductive age in the context of the potential risks associated with Zika virus infection.",Pubmed,March 31, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,No,Original research,No,Yes,335,Clinical/epidemiological research,Guidelines
336,"Jampol, JAMA Ophthalmol, 2016",Jampol,"Jampol, L. M., Goldstein, D. A.",Zika Virus Infection and the Eye,JAMA Ophthalmol,,,,2016,2010-present,February 13, 2016,26865476,10.1001/jamaophthalmol.2016.0284,1284,English,,"Department of Ophthalmology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.",,,,,,,Pubmed,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,336,,
337,"Chen, Ann Intern Med, 2016",Chen,"Chen, L. H.",Zika Virus Infection in a Massachusetts Resident After Travel to Costa Rica: A Case Report,Ann Intern Med,,,,2016,2010-present,February 13, 2016,26864175,10.7326/l16-0075,1287,English,,,,,,,,,Pubmed,March 31, 2016,Yes,,No,"Zika, not relevant to causality framework",Scientific (journal) article,Yes,Original research,No,Yes,337,Clinical/epidemiological research,Case report
338,"Kruger, Cell, 2016",Kruger,"Kruger, RP",Zika Virus on the Move,Cell,164,4,585-7,2016,2010-present,February 13, 2016,26871621,10.1016/j.cell.2016.01.040,1278,English,http://www.ncbi.nlm.nih.gov/pubmed/26871621,,,,,,,,Pubmed,March 31, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,338,,
339,"Goorhuis, Travel Med Infect Dis, 2016",Goorhuis,"Goorhuis, A., von Eije, K. J., Douma, R. A., Rijnberg, N., van Vugt, M., Stijnis, C., Grobusch, M. P.",Zika virus and the risk of imported infection in returned travelers: Implications for clinical care,Travel Med Infect Dis,14,1,13. Mai,2016,2010-present,February 14, 2016,26872416,10.1016/j.tmaid.2016.01.008,1277,English,,"Center of Tropical Medicine and Travel Medicine, Department of Infectious Diseases, Division of Internal Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. Electronic address: a.goorhuis@amc.uva.nl., Laboratory of Clinical Virology, Department of Medical Microbiology, Center for Infection and Immunity Amsterdam, Academic Medical Center, Amsterdam, The Netherlands., Center of Tropical Medicine and Travel Medicine, Department of Infectious Diseases, Division of Internal Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.",,,,,"Case series, Microcephaly, Sexual transmission, Travel, Zika virus","Since late 2015, an unprecedented outbreak of Zika virus is spreading quickly across Southern America. The large size of the current outbreak in The Americas will also result in an increase in Zika virus infections among travelers returning from endemic areas. We report five cases of imported Zika virus infection to The Netherlands. Although the clinical course is usually mild, establishing the diagnosis is important, mainly because of the association with congenital microcephaly and the possibility of sexual transmission.",Pubmed,March 31, 2016,Yes,,No,"Zika, not relevant to causality framework",Scientific (journal) article,No,Original research,No,Yes,339,Clinical/epidemiological research,Case series
340,"Heymann, Lancet, 2016",Heymann,"Heymann, D. L., Hodgson, A., Sall, A. A., Freedman, D. O., Staples, J. E., Althabe, F., Baruah, K., Mahmud, G., Kandun, N., Vasconcelos, P. F., Bino, S., Menon, K. U.",Zika virus and microcephaly: why is this situation a PHEIC?,Lancet,387,10020,719-21,2016,2010-present,February 16, 2016,26876373,10.1016/s0140-6736(16)00320-2,1275,English,,"Department of Infectious Disease Epidemiology, Faculty of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine, London, UK; Centre on Global Health Security, Chatham House, The Royal Institute of International Affairs, London SW1Y 4LE, UK. Electronic address: david.heymann@phe.gov.uk., Research and Development Division, Ghana Health Service, Accra, Ghana., WHO Collaborating Centre for Arboviruses and Viral Haemorrhagic Fevers, Senegal Institut Pasteur de Dakar, Dakar, Senegal., Division of Infectious Diseases, University of Alabama at Birmingham, Birmingham, AL, USA., Division of Vector-borne Diseases, Centers for Disease Control and Prevention, Fort Collins, CO, USA., Department of Maternal and Child Health Research, Institute for Clinical Effectiveness and Health Policy, Buenos Aires, Argentina., National Vector Borne Disease Control Programme, Ministry of Health and Family Welfare, Government of India, New Delhi, India., Faculty of Medicine, Quaid i Azam University, Quaid i Azam Post Graduate Medical College, Pakistan Institute of Medical Sciences, Islamabad, Pakistan., Field Epidemiology Training Program, Ministry of Health, Jakarta, Indonesia., Department of Arbovirology and Hemorrhagic Fevers, Evandro Chagas Institute, Ananindeua, Brazil., Control of Infectious Diseases Department, Institute of Public Health, Tirana, Albania., Ministry of Communications and Information, Singapore.",,,,,"Emergencies, *Global Health, Humans, Microcephaly/epidemiology/*virology, Public Health, World Health Organization, Zika Virus Infection/*complications/epidemiology",,Pubmed,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,340,,
341,"Ginier, Travel Med Infect Dis, 2016",Ginier,"Ginier, M., Neumayr, A., Gunther, S., Schmidt-Chanasit, J., Blum, J.",Zika without symptoms in returning travellers: What are the implications?,Travel Med Infect Dis,14,1,16-20,2016,2010-present,February 16, 2016,26876061,10.1016/j.tmaid.2016.01.012,1276,English,,"University of Lausanne, Switzerland; Swiss Tropical and Public Health Institute, Basel, Switzerland., Swiss Tropical and Public Health Institute, Basel, Switzerland; University of Basel, Switzerland. Electronic address: andreas.neumayr@unibas.ch., WHO Collaborating Centre for Arbovirus and Haemorrhagic Fever Reference and Research, Bernhard-Nocht Institute for Tropical Medicine, Hamburg, Germany; German Centre for Infection Research (DZIF), Partner Site Hamburg-Luebeck-Borstel, Hamburg, Germany., Swiss Tropical and Public Health Institute, Basel, Switzerland; University of Basel, Switzerland.",,,,,"Flavivirus infection, Travel medicine, Zika virus","Against the background of the emergence and rapid spread of Zika virus (ZIKV) in the Americas, we report the case of an afebrile ZIKV infection in a traveller returning from Central America to highlight relevant clinical and diagnostic aspects. ZIKV should be considered in the differential diagnosis of patients with clinical symptoms suggestive of dengue or chikungunya fever. Given the frequent subfebril and afebrile manifestations of ZIKV infections, we propose abstaining from the term 'Zika fever (ZF)' in favour of 'Zika virus disease (ZVD)'. Owing to its unspecific clinical presentation and cross-reactivity in serological assays, ZVD may easily be missed or misdiagnosed as dengue fever. Until conclusive data on the currently suspected link between ZIKV infection in pregnancy and foetal microcephaly become available, pregnant women and women who are trying to become pregnant should be advised against travelling to regions with ongoing ZIKV transmission. In addition, male travellers returning from regions with ongoing transmission should be informed of the potential risk of sexual transmission until conclusive data on the significance of this mode of transmission become available. Although probably low and seasonally restricted, there is a risk of ZIKV importation to Aedes mosquito-infested regions in temperate climates (including regions of North America and Europe) with consecutive autochthonous transmission.",Pubmed,March 31, 2016,Yes,,No,"Zika, not relevant to causality framework",Scientific (journal) article,Yes,Original research,No,Yes,341,Clinical/epidemiological research,Case report
342,"Wilson, Travel Med Infect Dis, 2016",Wilson,"Wilson, M. E.; Schlagenhauf, P.","Aedes and the triple threat of DENV, CHIKV, ZIKV - Arboviral risks and prevention at the 2016 Rio Olympic games",Travel Med Infect Dis,14,1,01. Apr,2016,2010-present,February 18, 2016,26879566,10.1016/j.tmaid.2016.01.010,1273,English,http://www.ncbi.nlm.nih.gov/pubmed/26879566,"Epidemiology and Biostatistics, School of Medicine, University of California, San Francisco, USA; Global Health and Population, Harvard T.H. Chan School of Public Health, Boston, MA, USA. Electronic address: mewilson@hsph.harvard.edu.; University of Zurich Centre for Travel Medicine, Institute for Epidemiology, Biostatistics and Prevention, WHO Collaborating Centre for Travellers' Health, Zurich, Switzerland.",,,,,,,Pubmed,March 31, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,342,,
343,"Rodríguez-Morales, Travel Med Infect Dis, 2016",Rodríguez-Morales,"Rodríguez-Morales, A. J.",Zika and microcephaly in Latin America: An emerging threat for pregnant travelers?,Travel Med Infect Dis,14,1,05. Jun,2016,2010-present,February 18, 2016,26879565,10.1016/j.tmaid.2016.01.011,1274,English,,"Working Group on Zoonoses, International Society for Chemotherapy, Public Health and Infection Research Group, Faculty of Health Sciences, Universidad Tecnologica de Pereira, Pereira, Risaralda, Colombia; Organizacion Latinoamericana para el Fomento de la Investigacion en Salud (OLFIS), Bucaramanga, Santander, Colombia. Electronic address: arodriguezm@utp.edu.co.",,,,,,,Pubmed,March 31, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,343,,
344,"Weitzel, Am J Trop Med Hyg, 2016",Weitzel,"Weitzel, T., Cortes, C. P.",Zika Virus Infection Presenting with Postauricular Lymphadenopathy,Am J Trop Med Hyg,,,,2016,2010-present,February 18, 2016,26884455,10.4269/ajtmh.16-0096,1271,English,,"Programa Medicina de Viajero, Clinica Alemana de Santiago, Facultad de Medicina Clinica Alemana, Universidad del Desarrollo, Santiago, Chile; Laboratorio Clinico, Clinica Alemana de Santiago, Facultad de Medicina Clinica Alemana, Universidad del Desarrollo, Santiago, Chile; Departamento de Infectologia, Clinica Santa Maria, Santiago, Chile; Departamento de Medicina, Escuela de Medicina, Universidad de Chile, Santiago, Chile thomas.weitzel@gmail.com., Programa Medicina de Viajero, Clinica Alemana de Santiago, Facultad de Medicina Clinica Alemana, Universidad del Desarrollo, Santiago, Chile; Laboratorio Clinico, Clinica Alemana de Santiago, Facultad de Medicina Clinica Alemana, Universidad del Desarrollo, Santiago, Chile; Departamento de Infectologia, Clinica Santa Maria, Santiago, Chile; Departamento de Medicina, Escuela de Medicina, Universidad de Chile, Santiago, Chile.",,,,,,"A 28-year-old, otherwise healthy Chilean man presented in December 2015 with fever,  headache, and myalgia. He had returned, 2 days ago, from a tourist trip to Colombia, where he  had visited Bogota and the northern region including Cartagena de Indias, Santa Marta, and  Tayrona National Park. During his return, he suffered nonspecific symptoms including sore  throat, anorexia, and myalgia. A day later, he noted high grade fever and tender nodules behind  his ears (Figure 1). Physical examination revealed fever (39.0°C), a maculopapular rash of the  trunk and extremities (Figure 2), mild conjunctivitis, and a generalized lymphadenopathy with  palpable tender axillary, cervical, and bilateral postauricular lymph nodes. After dengue and  chikungunya virus infections were excluded by molecular methods, antigen detection, and IgM  antibody testing, samples were sent to the national reference laboratory (Instituto de Salud  Pública de Chile, Santiago, Chile), where Zika virus (ZIKV) nucleic acids were detected by realtime  reverse transcription polymerase chain reaction (RT-PCR) as previously described.1 The  sample was also positive using a commercial RT-PCR assay for the detection of ZIKV (Zika  Virus genesig® Advanced Kit; Primerdesign™ Ltd., Southampton, United Kingdom) in the  clinical laboratory, Clinica Alemana, Santiago. The patient recovered rapidly and without  complications.",Pubmed,March 31, 2016,Yes,,No,"Zika, not relevant to causality framework",Scientific (journal) article,Yes,Original research,No,Yes,344,Clinical/epidemiological research,Case report
345,"Roa, Lancet, 2016",Roa,"Roa, M.",Zika virus outbreak: reproductive health and rights in Latin America,Lancet,387,10021,843,2016,2010-present,February 18, 2016,26880123,10.1016/s0140-6736(16)00331-7,1272,English,,"Women's Link Worldwide, Madrid, Spain. m.roa@womenslinkworldwide.org",,,,,"*Abortion, Induced, Contraception, *Disease Outbreaks, Female, Humans, Latin America, Pregnancy, *Pregnancy Complications, Infectious, Sex Education, *Zika Virus Infection",,Pubmed,March 31, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,345,,
346,"Meaney-Delman, Obstet Gynecol, 2016",Meaney-Delman,"Meaney-Delman, D., Rasmussen, S. A., Staples, J. E., Oduyebo, T., Ellington, S. R., Petersen, E. E., Fischer, M., Jamieson, D. J.",Zika Virus and Pregnancy: What Obstetric Health Care Providers Need to Know,Obstet Gynecol,127,4,642-8,2016,2010-present,February 19, 2016,26889662,10.1097/aog.0000000000001378,1269,English,,"Centers for Disease Control and Prevention, Atlanta, Georgia.",,,,,,"Zika virus is a flavivirus transmitted by Aedes (Stegomyia) species of mosquitoes. In May 2015, the World Health Organization confirmed the first local transmission of Zika virus in the Americas in Brazil. The virus has spread rapidly to other countries in the Americas; as of January 29, 2016, local transmission has been detected in at least 22 countries or territories, including the Commonwealth of Puerto Rico and the U.S. Virgin Islands. Zika virus can infect pregnant women in all three trimesters. Although pregnant women do not appear to be more susceptible to or more severely affected by Zika virus infection, maternal-fetal transmission has been documented. Several pieces of evidence suggest that maternal Zika virus infection is associated with adverse neonatal outcomes, most notably microcephaly. Because of the number of countries and territories with local Zika virus transmission, it is likely that obstetric health care providers will care for pregnant women who live in or have traveled to an area of local Zika virus transmission. We review information on Zika virus, its clinical presentation, modes of transmission, laboratory testing, effects during pregnancy, and methods of prevention to assist obstetric health care providers in caring for pregnant women considering travel or with a history of travel to areas with ongoing Zika virus transmission and pregnant women residing in areas with ongoing Zika virus transmission.",Pubmed,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,346,,
347,"Waggoner, J Clin Microbiol, 2016",Waggoner,"Waggoner, J. J., Pinsky, B. A.",Zika Virus: Diagnostics for an Emerging Pandemic Threat,J Clin Microbiol,54,4,860-7,2016,2010-present,February 19, 2016,26888897,10.1128/jcm.00279-16,1270,English,,"Department of Medicine, Division of Infectious Diseases and Geographic Medicine, Stanford University School of Medicine, Stanford, California, USA., Department of Medicine, Division of Infectious Diseases and Geographic Medicine, Stanford University School of Medicine, Stanford, California, USA Department of Pathology, Stanford University School of Medicine, Stanford, California, USA bpinsky@stanford.edu.",,,,,,"Zika virus (ZIKV) is anAedesmosquito-borne flavivirus that emerged in Brazil in 2015 and then rapidly spread throughout the tropical and subtropical Americas. Based on clinical criteria alone, ZIKV cannot be reliably distinguished from infections with other pathogens that cause an undifferentiated systemic febrile illness, including infections with two common arboviruses, dengue virus and chikungunya virus. This minireview details the methods that are available to diagnose ZIKV infection.",Pubmed,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,No,Review,No,Yes,347,Clinical/epidemiological research,Epidemiological/clinical review
348,"Thomas, MMWR Morb Mortal Wkly Rep, 2016",Thomas,"Thomas, D. L.; Sharp, T. M.; Torres, J.; Armstrong, P. A.; Munoz-Jordan, J.; Ryff, K. R.; Martinez-Quinones, A.; Arias-Berrios, J.; Mayshack, M.; Garayalde, G. J.; Saavedra, S.; Luciano, C. A.; Valencia-Prado, M.; Waterman, S.; Rivera-Garcia, B.","Local Transmission of Zika Virus - Puerto Rico, November 23, 2015-January 28, 2016",MMWR Morb Mortal Wkly Rep,65,6,154-8,2016,2010-present,February 20, 2016,26890470,10.15585/mmwr.mm6506e2,1267,English,http://www.ncbi.nlm.nih.gov/pubmed/26890470,,Puerto Rico,Americas,Puerto Rico,Not reported/unknown,,,Pubmed,March 31, 2016,Yes,,Yes,,Scientific (journal) article,No,Original research,No,Yes,348,Clinical/epidemiological research,Case report
349,"Martines, MMWR Morb Mortal Wkly Rep, 2016",Martines,"Martines, R. B.; Bhatnagar, J.; Keating, M. K.; Silva-Flannery, L.; Muehlenbachs, A.; Gary, J.; Goldsmith, C.; Hale, G.; Ritter, J.; Rollin, D.; Shieh, W. J.; Luz, K. G.; Ramos, A. M.; Davi, H. P.; Kleber de Oliveria, W.; Lanciotti, R.; Lambert, A.; Zaki, S.","Notes from the Field: Evidence of Zika Virus Infection in Brain and Placental Tissues from Two Congenitally Infected Newborns and Two Fetal Losses - Brazil, 2015",MMWR Morb Mortal Wkly Rep,65,6,159-60,2016,2010-present,February 20, 2016,26890059,10.15585/mmwr.mm6506e1,1268,English,http://www.ncbi.nlm.nih.gov/pubmed/26890059,RBrasilMartines@cdc.gov,United States,Americas,United States,Not reported/unknown,,"Zika virus is a mosquito-borne flavivirus that is related to dengue virus and transmitted primarily by Aedes aegypti mosquitoes, with humans acting as the principal amplifying host during outbreaks. Zika virus was first reported in Brazil in May 2015 (1). By February 9, 2016, local transmission of infection had been reported in 26 countries or territories in the Americas.* Infection is usually asymptomatic, and, when symptoms are present, typically results in mild and self-limited illness with symptoms including fever, rash, arthralgia, and conjunctivitis. However, a surge in the number of children born with microcephaly was noted in regions of Brazil with a high prevalence of suspected Zika virus disease cases. More than 4,700 suspected cases of microcephaly were reported from mid-2015 through January 2016, although additional investigations might eventually result in a revised lower number (2). In response, the Brazil Ministry of Health established a task force to further investigate possible connections between the virus and brain anomalies in infants (3).",Pubmed,March 31, 2016,Yes,,Yes,,Scientific (journal) article,No,Original research,No,Yes,349,Clinical/epidemiological research,Case series
350,"Mor, Am J Reprod Immunol, 2016",Mor,"Mor, G.",Placental Inflammatory Response to Zika Virus may Affect Fetal Brain Development,Am J Reprod Immunol,75,4,421-2,2016,2010-present,February 20, 2016,26892436,10.1111/aji.12505,1266,English,,"Department of Obstetrics Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT, 06520, USA.",,,,,,,Pubmed,March 31, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,350,,
351,"Kline, JAMA Pediatr, 2016",Kline,"Kline, M. W., Schutze, G. E.",What Pediatricians and Other Clinicians Should Know About Zika Virus,JAMA Pediatr,,,,2016,2010-present,February 20, 2016,26893150,10.1001/jamapediatrics.2016.0429,1265,English,,"Department of Pediatrics, Baylor College of Medicine, Texas Children's Hospital, Houston.",,,,,,"Zika virus is the latest, but likely not the last, formerly obscure and geographically isolated virus to suddenly exhibit the potential for pandemic spread. Human immunodeficiency virus, Ebola virus, dengue virus, and chikungunya virus are examples of other viruses that have spread widely at least in part as a consequence of growing trends of urbanization and globalization. During the past 10 months, the explosive growth in recognized cases of Zika virus disease across much of South and Central America and the Caribbean as well as a purported association between Zika virus disease in pregnancy and fetal and neonatal microcephaly has produced concern among public health authorities and the lay public about the possibility of Zika virus transmission in the United States.",Pubmed,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,No,Comment/Editorial/Perspective/Letter,No,Yes,351,,
352,"McCarthy, BMJ, 2016",McCarthy,"McCarthy, M.",WHO sets out $56m Zika virus response plan,BMJ,352,,i1042,2016,2010-present,February 20, 2016,26893468,10.1136/bmj.i1042,1264,English,,Seattle.,,,,,,,Pubmed,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,News item or lay press,,,No,Yes,352,,
353,"Simkiss, J Trop Pediatr, 2016",Simkiss,"Simkiss, D.",Zika Virus,J Trop Pediatr,62,1,01. Feb,2016,2010-present,February 21, 2016,26895850,10.1093/tropej/fmw006,1263,English,,University of Warwick.,,,,,,,Pubmed,March 31, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,353,,
354,"Birbeck, Neurology, 2016",Birbeck,"Birbeck, G. L.",Zika virus: What the neurologist wants to know,Neurology,,,,2016,2010-present,February 21, 2016,26896047,10.1212/wnl.0000000000002553,1262,English,,"From the School of Medicine and Dentistry, University of Rochester, NY. gretchen_birbeck@urmc.rochester.edu.",,,,,,,Pubmed,March 31, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,354,,
355,"Calvet, Lancet Infect Dis, 2016",Calvet,"Calvet, G.; Aguiar, R. S.; Melo, A. S.; Sampaio, S. A.; de Filippis, I.; Fabri, A.; Araujo, E. S.; de Sequeira, P. C.; de Mendonca, M. C.; de Oliveira, L.; Tschoeke, D. A.; Schrago, C. G.; Thompson, F. L.; Brasil, P.; Dos Santos, F. B.; Nogueira, R. M.; Tanuri, A.; de Filippis, A. M.",Detection and sequencing of Zika virus from amniotic fluid of fetuses with microcephaly in Brazil: a case study,Lancet Infect Dis,,,,2016,2010-present,February 22, 2016,26897108,10.1016/S1473-3099(16)00095-5,1260,English,http://www.ncbi.nlm.nih.gov/pubmed/26897108,"Laboratório de Flavivírus, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz,  Rio de Janeiro 21040-900, Brazil abispo@ioc.fiocruz.br",Brazil,Americas,Brazil,Public/Government,,"BACKGROUND: The incidence of microcephaly in Brazil in 2015 was 20 times higher than in previous years. Congenital microcephaly is associated with genetic factors and several causative agents. Epidemiological data suggest that microcephaly cases in Brazil might be associated with the introduction of Zika virus. We aimed to detect and sequence the Zika virus genome in amniotic fluid samples of two pregnant women in Brazil whose fetuses were diagnosed with microcephaly. METHODS: In this case study, amniotic fluid samples from two pregnant women from the state of Paraiba in Brazil whose fetuses had been diagnosed with microcephaly were obtained, on the recommendation of the Brazilian health authorities, by ultrasound-guided transabdominal amniocentesis at 28 weeks' gestation. The women had presented at 18 weeks' and 10 weeks' gestation, respectively, with clinical manifestations that could have been symptoms of Zika virus infection, including fever, myalgia, and rash. After the amniotic fluid samples were centrifuged, DNA and RNA were extracted from the purified virus particles before the viral genome was identified by quantitative reverse transcription PCR and viral metagenomic next-generation sequencing. Phylogenetic reconstruction and investigation of recombination events were done by comparing the Brazilian Zika virus genome with sequences from other Zika strains and from flaviviruses that occur in similar regions in Brazil. FINDINGS: We detected the Zika virus genome in the amniotic fluid of both pregnant women. The virus was not detected in their urine or serum. Tests for dengue virus, chikungunya virus, Toxoplasma gondii, rubella virus, cytomegalovirus, herpes simplex virus, HIV, Treponema pallidum, and parvovirus B19 were all negative. After sequencing of the complete genome of the Brazilian Zika virus isolated from patient 1, phylogenetic analyses showed that the virus shares 97-100% of its genomic identity with lineages isolated during an outbreak in French Polynesia in 2013, and that in both envelope and NS5 genomic regions, it clustered with sequences from North and South America, southeast Asia, and the Pacific. After assessing the possibility of recombination events between the Zika virus and other flaviviruses, we ruled out the hypothesis that the Brazilian Zika virus genome is a recombinant strain with other mosquito-borne flaviviruses. INTERPRETATION: These findings strengthen the putative association between Zika virus and cases of microcephaly in neonates in Brazil. Moreover, our results suggest that the virus can cross the placental barrier. As a result, Zika virus should be considered as a potential infectious agent for human fetuses. Pathogenesis studies that confirm the tropism of Zika virus for neuronal cells are warranted. ",Pubmed,March 31, 2016,Yes,,Yes,,Scientific (journal) article,Yes,Original research,Yes,Yes,355,Clinical/epidemiological research,Case series
356,"Musso, Lancet Infect Dis, 2016",Musso,"Musso, D., Baud, D.",Zika virus: time to move from case reports to case control,Lancet Infect Dis,,,,2016,2010-present,February 22, 2016,26897106,10.1016/s1473-3099(16)00096-7,1261,English,,"Unit of Emerging Infectious Diseases, Institut Louis Malarde, PO Box 30, 98713 Papeete, Tahiti, French Polynesia. Electronic address: dmusso@ilm.pf., Materno-Fetal and Obstetrics Research Unit, Department Femme-Mere-Enfant, Maternity, University Hospital, Lausanne, Switzerland; Institute of Microbiology, Faculty of Biology and Medicine, University of Lausanne and University Hospital, Lausanne, Switzerland.",,,,,,"Until the French Polynesian outbreak in 2013-14, Zika virus disease was thought to be only a mild disease. During this outbreak, the incidence of Guillain-Barré syndrome was 20 times higher than expected.1 Similarly, the emergence of Zika virus in the Americas since 2015 has been associated with a dramatic increase of reported cases of microcephaly.2 As for Zika virus and Guillain-Barré syndrome in French Polynesia, the temporal association between Zika virus outbreaks and microcephaly in Brazil strongly suggests that Zika virus infection during pregnancy might cause severe neurological damage in neonates.",Pubmed,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,356,,
357,"Vouga, Lancet, 2016",Vouga,"Vouga, M.; Musso, D.; Van Mieghem, T.; Baud, D.",CDC guidelines for pregnant women during the Zika virus outbreak,Lancet,387,10021,843-4,2016,2010-present,February 24, 2016,26898855,10.1016/S0140-6736(16)00383-4,1257,English,http://www.ncbi.nlm.nih.gov/pubmed/26898855,"Materno-fetal and Obstetrics Research Unit, Department Femme-Mere-Enfant, Centre Hospitalier Universitaire Vaudois, 1011 Lausanne, Switzerland; Institute of Microbiology, Faculty of Biology and Medicine, University of Lausanne and University Hospital, Lausanne, Switzerland.; Unit of Emerging Infectious Diseases, Institut Louis Malarde, Tahiti, French Polynesia.; Department of Obstetrics and Gynecology, Division of Woman and Child, University Hospitals Leuven, Leuven, Belgium.; Materno-fetal and Obstetrics Research Unit, Department Femme-Mere-Enfant, Centre Hospitalier Universitaire Vaudois, 1011 Lausanne, Switzerland; Institute of Microbiology, Faculty of Biology and Medicine, University of Lausanne and University Hospital, Lausanne, Switzerland. Electronic address: david.baud@chuv.ch.",,,,,"*Amniocentesis/adverse effects; Centers for Disease Control and Prevention (U.S.); Female; Humans; *Practice Guidelines as Topic; Pregnancy; Pregnancy Complications, Infectious/*diagnosis; United States; Zika Virus Infection/*diagnosis","Zika virus is attracting worldwide attention and everyone fears its potential dramatic effects on the fetal brain. The US Centers for Disease Control and Prevention (CDC) have recently published interim guidelines on management of pregnant women exposed to Zika virus.1 We do, however, have some comments on these recommendations.",Pubmed,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,357,,
358,"Pastula, J Neurovirol, 2016",Pastula,"Pastula, D. M.; Smith, D. E.; Beckham, J. D.; Tyler, K. L.","Four emerging arboviral diseases in North America: Jamestown Canyon, Powassan, chikungunya, and Zika virus diseases",J Neurovirol,,,,2016,2010-present,February 24, 2016,26903031,10.1007/s13365-016-0428-5,1254,English,http://www.ncbi.nlm.nih.gov/pubmed/26903031,"Neuro-Infectious Diseases Group, Department of Neurology and Division of Infectious Diseases, University of Colorado Denver, 12401 East 17th Avenue, Mailstop L950, Room 486, Aurora, CO, 80045, USA. Daniel.Pastula@ucdenver.edu.; Neuro-Infectious Diseases Group, Department of Neurology and Division of Infectious Diseases, University of Colorado Denver, 12401 East 17th Avenue, Mailstop L950, Room 486, Aurora, CO, 80045, USA.",,,,,Arboviral disease; Arbovirus; Chikungunya virus; Jamestown Canyon virus; North America; Powassan virus; Zika virus,"Arthropod-borne viruses, or arboviruses, are viruses that are transmitted through the bites of mosquitoes, ticks, or sandflies. There are numerous arboviruses throughout the world capable of causing human disease spanning different viral families and genera. Recently, Jamestown Canyon, Powassan, chikungunya, and Zika viruses have emerged as increasingly important arboviruses that can cause human disease in North America. Unfortunately, there are currently no proven disease-modifying therapies for these arboviral diseases, so treatment is largely supportive. Given there are also no commercially available vaccines for these four arboviral infections, prevention is the key. To prevent mosquito or tick bites that might result in one of these arboviral diseases, people should wear long-sleeved shirts and pants while outside if feasible, apply insect repellant when going outdoors, using window screens or air conditioning to keep mosquitoes outside, and perform tick checks after being in wooded or brushy outdoor areas.",Pubmed,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Yes,Review,No,Yes,358,Clinical/epidemiological research,Epidemiological/clinical review
359,"Gulland, BMJ, 2016",Gulland,"Gulland, A.",Genetically modified mosquitos may be used in fight against Zika,BMJ,352,,i1086,2016,2010-present,February 24, 2016,26902867,10.1136/bmj.i1086,1255,English,http://www.ncbi.nlm.nih.gov/pubmed/26902867,London.,,,,,,,Pubmed,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,News item or lay press,,,No,Yes,359,,
360,"Society for Maternal-Fetal Medicine Publications, Am J Obstet Gynecol, 2016",Society for Maternal-Fetal Medicine Publications,"Society for Maternal-Fetal Medicine Publications, Committee",Ultrasound screening for fetal microcephaly following Zika virus exposure,Am J Obstet Gynecol,,,,2016,2010-present,February 24, 2016,26901275,10.1016/j.ajog.2016.02.043,1256,English,http://www.ncbi.nlm.nih.gov/pubmed/26901275,,,,,,,,Pubmed,March 31, 2016,Yes,,No,"Zika, not relevant to causality framework",Scientific (journal) article,Yes,Original research,No,Yes,360,Clinical/epidemiological research,Guidelines
361,"Christofferson, Am J Trop Med Hyg, 2016",Christofferson,"Christofferson, R. C.",Zika Virus Emergence and Expansion: Lessons Learned from Dengue and Chikungunya May Not Provide All the Answers,Am J Trop Med Hyg,,,,2016,2010-present,February 24, 2016,26903610,10.4269/ajtmh.15-0866,1253,English,,"Department of Pathobiological Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, Louisiana rcarri1@lsu.edu.",,,,,,"Following the emergence of Zika in the past decade, there are lessons to be learned from similar emergence events of dengue (DENV) and chikungunya (CHIKV). Specifically, as Zika emerges in the Americas there is a natural tendency to apply the knowledge base of DENV and CHIKV to mitigation and control of a virus with such a similar transmission system. However, there are marked differences that may preclude such broad stroke application of this knowledge base without making potentially faulty assumptions. Herein, Zika virus (ZIKV) transmission is reviewed, and the commonalities among these three arboviruses are discussed. Importantly, the divergence of this particular arbovirus is discussed, as is the need to develop ZIKV-specific knowledge base for mitigation of this disease. Specifically reviewed are 1) emergence and persistence patterns, 2) genetic and phenotypic diversity, 3) vector host range, and finally, 4) alternate transmission routes and added complexity of ZIKV transmission and presentation.",Pubmed,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Yes,Review,No,Yes,361,Clinical/epidemiological research,Epidemiological/clinical review
362,"WHO, Wkly Epidemiol Rec, 2016",WHO,WHO,Zika virus infection: global update on epidemiology and potentially associated clinical manifestations,Wkly Epidemiol Rec,91,7,73-81,2016,2010-present,February 24, 2016,26897760,,1259,English,http://www.ncbi.nlm.nih.gov/pubmed/26897760,,Switzerland,Europe,,Public/Government,"Africa/epidemiology; Asia/epidemiology; Central America/epidemiology; Communicable Diseases, Emerging/*complications/*epidemiology/prevention & control; Disease Outbreaks/prevention & control/*statistics & numerical data; Global Health/*statistics & numerical data; Guillain-Barre Syndrome/epidemiology/virology; Humans; Microcephaly/epidemiology/virology; South America/epidemiology; Zika Virus; Zika Virus Infection/*complications/*epidemiology/prevention & control",,Pubmed,March 31, 2016,Yes,,No,"Zika, indirect evidence or other topic",Surveillance report or data,,,No,Yes,362,Clinical/epidemiological research,Ecological study/outbreak report
363,"Maria, Eurosurveillance, 2016",Maria,"Maria, A. T., Maquart, M., Makinson, A., Flusin, O., Segondy, M., Leparc-Goffart, I., Le Moing, V., Foulongne, V.","Zika virus infections in three travellers returning from South America and the Caribbean respectively, to Montpellier, France, December 2015 to January 2016",Eurosurveillance,21,6,,2016,2010-present,February 24, 2016,26898198,10.2807/1560-7917.es.2016.21.6.30131,1258,English,,"Department of Infectious Diseases and Tropical Medicine, Montpellier University Hospital, Montpellier, France.",,,,,"Caribbean, France, South America, Zika virus, imported viral disease","We report three unrelated cases of Zika virus infection in patients returning from Martinique, Brazil and Colombia respectively, to Montpellier, France. They developed symptoms compatible with a mosquito-borne disease, and serological and molecular investigations indicated a recent Zika virus infection. Considering the recent warning for the likely teratogenicity of Zika virus and the presence of competent mosquito vectors in southern France, these cases highlight the need for awareness of physicians and laboratories in Europe.",Pubmed,March 31, 2016,Yes,,No,"Zika, not relevant to causality framework",Scientific (journal) article,Yes,Original research,No,Yes,363,Clinical/epidemiological research,Case series
364,"Deng, Zhonghua Wei Zhong Bing Ji Jiu Yi Xue, 2016",Deng,"Deng, Y.; Zeng, L.; Bao, W.; Xu, P.; Zhong, G.",[Experience of integrated traditional Chinese and Western medicine in first case of imported Zika virus disease in China],Zhonghua Wei Zhong Bing Ji Jiu Yi Xue,28,2,106-9,2016,2010-present,February 26, 2016,26911940,10.3760/cma.j.issn.2095-4352.2016.02.005,1245,Other,http://www.ncbi.nlm.nih.gov/pubmed/26911940,"Department of Infectious Disease, Ganxian People's Hospital, Ganxian 341100, Jiangxi, China. Corresponding author: Zhong Gongrong, Email: zgr1965@sina.com.",,,,,,"OBJECTIVE: Zika virus disease is an acute infectious disease caused by Zika virus transmitted through Aedes mosquitoes. To explore the therapeutic effect of integrated traditional Chinese and Western Medicine for Zika virus disease, the treatment process of the first imported case in China was reviewed. METHODS: The first imported Zika virus disease in China was admitted to Ganxian People's Hospital in Jiangxi Province on February 6th, 2016, and the patient received isolation treatment for 9 days and cured later. The effect of antiviral treatments including Xiyanping injection was evaluated based on clinical diagnosis and treatment process of the patient. RESULTS: A 34-year old male patient was admitted with chief complaint of fever for 9 days, orbital pain and itching rash for 4 days on February 6th, 2016. (1) Epidemiological characteristics: the patient was bitted by mosquitoes during his business trip in Venezuela since January 1st, where Zika virus disease was spreading. On January 20th he had dizziness without fever, and the symptom disappeared after taking medicines without details. Paroxysmal dizziness, chills and mild fever without myalgia was experienced on January 28th. On February 3rd small red rash appeared in the neck, spreading to anterior part of chest, limbs and trunk, and the fever, fatigue, nausea was continued, and a new symptom of paroxysmal pain in back of ears and orbits appeared, during which he had not go to hospital. The symptoms relieved on February 4th. He returned to Ganxian County on February 5th, he had yellow stool 3 times with normal temperature, without abdominal pain, and red rash still appeared in the neck. He went to Ganxian People's Hospital on February 6th, 2016. (2) Clinical manifestation: the vital signs showed a temperature of 36.8?centigrade, a pulse rate of 80 bpm, a respiratory rate of 20 bpm, and a blood pressure of 110/70 mmHg (1 mmHg = 0.133 kPa). It was showed by physical examination that red rash appeared in the neck, and no superficial enlarged lymph nodes were found. Bilateral conjunctival congestion was obvious, physiological reflex existed and pathological reflex was not found. (3) Auxiliary lab test and examination: no abnormal finding were revealed throughout examination and laboratory tests, including routine blood test, liver function, renal function, serum myocardial enzyme, electrolyte, blood sugar, C-reactive protein (CRP), troponin I (TnI), and procalcitonin (PCT), except slight prolongation in activated partial thromboplastin time (APTT, 38.6 s) on February 6th; and slightly dense shadow in left lung in lung CT scan, considering inflammatory changes and slight emphysema (especially in the left lower lung) as well as bilateral renal calculus on February 8th. No significant abnormalities were found in electrocardiogram and B ultrasound test of liver, spleen, and pancreas. (4) Virus confirmation: Zika virus nucleic acid was positive reported by Jiangxi Province Center for Disease Control and Prevention (CDC) on February 7th and Chinese CDC on February 9th, respectively, though Dengue virus were negative reported by Ganzhou CDC on February 6th. Right after the first diagnosis, anyone who had been in close contact with the patient received medical monitoring. (5)Treatment process: on February 6th, symptomatic treatment was prescribed since admitted into the infectious isolation wards and daily intravenous drip of Xiyanping injection 250 mg was prescribed for antiviral therapy. On February 7th, the patient had no fever, with occasional chills, neck rash was disappeared, orbital pain relieved and bilateral conjunctival hyperemia range was paler and narrowed, and his condition improved. Ibuprofen was administered for defervesce 3 times a day when his temperature reached to 37.5?centigrade at 16:00. On February 8th, the patient had no fever, times of chills was significantly reduced, without myalgia and rash, orbital pain and conjunctival hyperemia further recovered. On February 9th, bilateral eyes slightly tingling, mild conjunctival congestion, no fever chills or other discomfort was found. The chloramphenicol eye drops was prescribed for relieving sting pain with conjunctival congestion twice a day as recombinant human interferon alpha eye drops was out of store. The patient was comfortable from February 11th to February 13th. Blood and urine test for Zika were reported negative by the Chinese CDC and Jiangxi Province CDC. Because all the discharge criteria were satisfied, the patient was discharged on February 14th. CONCLUSIONS: At present, there is no specific effective drug to prevent and treat Zika virus disease effectually. After receiving symptomatic treatment and antiviral treatments including Xiyanping injection, the patient's symptoms were relieved. Zika virus nucleic acid in blood and urine was negative. The patient was discharged. Combination of traditional Chinese medicine and Western medicine maybe a good method to prevent and treat Zika virus disease.",Pubmed,March 31, 2016,Yes,,No,"Zika, not relevant to causality framework",Scientific (journal) article,Yes,Original research,No,Yes,364,Clinical/epidemiological research,Case report
365,"Howard, Emerg Microbes Infect, 2016",Howard,"Howard, C. R.",Aedes mosquitoes and Zika virus infection: an A to Z of emergence?,Emerg Microbes Infect,5,1,e16,2016,2010-present,February 26, 2016,26905027,10.1038/emi.2016.37,1252,English,http://www.ncbi.nlm.nih.gov/pubmed/26905027,"College of Medicine and Dentistry, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.",,,,,,,Pubmed,March 31, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,365,,
366,"Graham, Eur J Emerg Med, 2016",Graham,"Graham, C. A.","Continuing challenges: migrants, terrorism, weather and Zika",Eur J Emerg Med,23,2,79,2016,2010-present,February 26, 2016,26908259,10.1097/MEJ.0000000000000384,1248,English,http://www.ncbi.nlm.nih.gov/pubmed/26908259,"Editor-in-Chief, European Journal of Emergency Medicine, Chinese University of Hong Kong, Shatin, Hong Kong.",,,,,,,Pubmed,March 31, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,No,Comment/Editorial/Perspective/Letter,No,Yes,366,,
367,"McNutt, Science, 2016",McNutt,"McNutt, M.",Data sharing,Science,351,6277,1007,2016,2010-present,February 26, 2016,26912369,10.1126/science.aaf4545,1244,English,http://www.ncbi.nlm.nih.gov/pubmed/26912369,"Marcia McNutt is Editor-in-Chief, Science Journals.",,,,,"*Access to Information; *Emergency Medicine; *Global Health; Hemorrhagic Fever, Ebola/epidemiology; Humans; *Information Dissemination; *Public Health; World Health Organization; Zika Virus Infection/epidemiology",,Pubmed,March 31, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,No,Comment/Editorial/Perspective/Letter,No,Yes,367,,
368,"Costa, Ann Intern Med, 2016",Costa,"Costa, F.; Sarno, M.; Khouri, R.; de Paulo Freitas, B.; Siqueira, I.; Ribeiro, G. S.; Ribeiro, H. C.; Campos, G. S.; Alcantara, L. C.; Reis, M. G.; Weaver, S. C.; Vasilakis, N.; Ko, A. I.; Almeida, A. R.",Emergence of Congenital Zika Syndrome: Viewpoint From the Front Lines,Ann Intern Med,,,,2016,2010-present,February 26, 2016,26914810,10.7326/M16-0332,1234,English,http://www.ncbi.nlm.nih.gov/pubmed/26914810,,,,,,,,Pubmed,March 31, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,368,,
369,"Shakib, Br J Oral Maxillofac Surg, 2016",Shakib,"Shakib, K.",Epidemic of Zika virus and maxillofacial surgery,Br J Oral Maxillofac Surg,,,,2016,2010-present,February 26, 2016,26907929,10.1016/j.bjoms.2016.02.001,1249,English,http://www.ncbi.nlm.nih.gov/pubmed/26907929,"Department of Oral & Maxillofacial Surgery, Royal Free Hospital London. Electronic address: k.shakib@nhs.net.",,,,,Guillain-Barre syndrome; Microcephaly; Virus induced congenital malformation; Zika virus,"Zika is a RNA virus spread by the ubiquitous Aedes mosquitoes. It was first discovered in Uganda in 1947, and arrived in south-east Asia by the middle of the 20th century. In 2014 the virus started to spread across the Pacific Islands to reach South America. Since then it has spread rapidly northwards, and reached Mexico and the Caribbean in November 2015. Clinically it presents as a self-limiting febrile illness. However, there is increasing evidence of a link between Zika virus and the Guillain-Barre syndrome, and maternal Zika virus infection and microcephaly of the fetus.",Pubmed,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,369,,
370,"Cohen, Science, 2016",Cohen,"Cohen, J.",INFECTIOUS DISEASE. The race for a Zika vaccine is on,Science,351,6273,543-4,2016,2010-present,February 26, 2016,26912676,10.1126/science.351.6273.543,1243,English,http://www.ncbi.nlm.nih.gov/pubmed/26912676,,,,,,Humans; Marketing; Mass Vaccination/economics; National Institute of Allergy and Infectious Diseases (U.S.); United States; Viral Vaccines/economics/*immunology; Zika Virus/*immunology; Zika Virus Infection/*prevention & control,,Pubmed,March 31, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",News item or lay press,,,No,Yes,370,,
371,"Currie, Science, 2016",Currie,"Currie, J.; Grenfell, B.; Farrar, J.",Infectious diseases. Beyond Ebola,Science,351,6275,815-6,2016,2010-present,February 26, 2016,26912880,10.1126/science.aad8521,1241,English,http://www.ncbi.nlm.nih.gov/pubmed/26912880,"Princeton University, Woodrow Wilson School, Princeton, NJ 08540, USA. jcurrie@princeton.edu.; Princeton University, Woodrow Wilson School, Princeton, NJ 08540, USA.; Wellcome Trust, 215 Euston Road, London NW1 2BE, UK.",,,,,"Animals; Communicable Disease Control/*methods/*organization & administration; Delivery of Health Care; Disease Reservoirs; Epidemics/*prevention & control; *Global Health; Hemorrhagic Fever, Ebola/epidemiology/prevention & control; Humans; International Cooperation; Zika Virus Infection/epidemiology/prevention & control; Zoonoses/prevention & control/transmission",,Pubmed,March 31, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,No,Comment/Editorial/Perspective/Letter,No,Yes,371,,
372,"Azevedo-Santos, Science, 2016",Azevedo-Santos,"Azevedo-Santos, V. M.; Vitule, J. R.; Garcia-Berthou, E.; Pelicice, F. M.; Simberloff, D.",Misguided strategy for mosquito control,Science,351,6274,675,2016,2010-present,February 26, 2016,26912851,10.1126/science.351.6274.675,1242,English,http://www.ncbi.nlm.nih.gov/pubmed/26912851,"Laboratorio de Ictiologia, Departamento de Zoologia, Universidade Estadual Paulista 'Julio de Mesquita Filho, Campus de Botucatu,' SP, 18618-970, Brazil. valter.ecologia@gmail.com.; Laboratorio de Ecologia e Conservacao (LEC), Universidade Federal do Parana, Curitiba, PR, 81531-970, Brazil.; Institute of Aquatic Ecology, University of Girona, Catalonia, Spain.; Nucleo de Estudos Ambientais, Universidade Federal de Tocantins, Porto Nacional, TO, 77500-000, Brazil.; Department of Ecology and Evolutionary Biology, University of Tennessee, Knoxville, TN 37996, USA.",,,,,Aedes/growth & development/*virology; Animals; Biodiversity; Brazil; Chikungunya virus; Dengue Virus; Humans; *Introduced Species; Larva; Mosquito Control/*methods; *Poecilia; Zika Virus,,Pubmed,March 31, 2016,Yes,,No,Unrelated to Zika virus,Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,372,,
373,"Omer, JAMA, 2016",Omer,"Omer, S. B., Beigi, R. H.",Pregnancy in the Time of Zika: Addressing Barriers for Developing Vaccines and Other Measures for Pregnant Women,JAMA,315,12,1227-8,2016,2010-present,February 26, 2016,26914692,10.1001/jama.2016.2237,1236,English,,"Departments of Global Health, Epidemiology, and Pediatrics, Emory University, Atlanta, Georgia., Department of Obstetrics, Gynecology, and Reproductive Sciences, Magee-Women's Hospital of University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.",,,,,"Drug Labeling/legislation & jurisprudence, Ethics, Research, Female, Humans, Pregnancy, Pregnancy Complications, Infectious/*prevention & control/virology, *Pregnant Women, Safety, *Viral Vaccines/administration & dosage/adverse effects, Zika Virus/*immunology, Zika Virus Infection/*prevention & control/virology",,Pubmed,March 31, 2016,Yes,,No,"Zika, not relevant to causality framework",Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,373,,
374,"Jacob, JAMA, 2016",Jacob,"Jacob, J. A.",Researchers Focus on Solving the Zika Riddles,JAMA,315,11,1097-9,2016,2010-present,February 26, 2016,26914596,10.1001/jama.2016.1219,1237,English,,,,,,,"Brazil/epidemiology, Causality, Humans, Microcephaly/epidemiology/immunology/*virology, Sexually Transmitted Diseases, Viral/complications/prevention & control/virology, Viral Vaccines, Zika Virus/immunology/pathogenicity, Zika Virus Infection/*complications/prevention & control/transmission",,Pubmed,March 31, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",News item or lay press,,,No,Yes,374,,
375,"Karimi, Lancet, 2016",Karimi,"Karimi, O., Goorhuis, A., Schinkel, J., Codrington, J., Vreden, S. G., Vermaat, J. S., Stijnis, C., Grobusch, M. P.",Thrombocytopenia and subcutaneous bleedings in a patient with Zika virus infection,Lancet,387,10022,939-40,2016,2010-present,February 26, 2016,26906627,10.1016/s0140-6736(16)00502-x,1251,English,,"Center of Tropical Medicine and Travel Medicine, Department of Infectious Diseases, Academic Medical Center, University of Amsterdam, 1100 DD Amsterdam, Netherlands., Division of Internal Medicine, and Laboratory of Clinical Virology, Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, 1100 DD Amsterdam, Netherlands., Department of Laboratory, Academic Hospital Paramaribo, Paramaribo, Suriname., Internal Medicine and Infectious Diseases, Academic Hospital Paramaribo, Paramaribo, Suriname., Department of Hematology, Academic Medical Center, University of Amsterdam, 1100 DD Amsterdam, Netherlands., Center of Tropical Medicine and Travel Medicine, Department of Infectious Diseases, Academic Medical Center, University of Amsterdam, 1100 DD Amsterdam, Netherlands. Electronic address: m.p.grobusch@amc.uva.nl.",Netherlands,Europe,Suriname,Not reported/unknown,"Female, Hematoma/*virology, Humans, Middle Aged, Netherlands, Suriname, Thrombocytopenia/*virology, Travel, Zika Virus Infection/*complications/*diagnosis","Zika virus is a Flavivirus transmitted to human beings primarily through the bites of Aedes spp. Mild thrombocytopenia has been described only once in the past. However, unconfirmed preliminary clinical reports from the ongoing outbreak suggest moderate  thrombocytopenia as an infrequent, but not uncommon, finding. This case reports a patient with Zika virus infection that was related to clinically relevant thrombocytopenia and subcutaneous haematomas",Pubmed,March 31, 2016,Yes,,No,"Zika, indirect evidence or other topic",Scientific (journal) article,Yes,Original research,No,Yes,375,Clinical/epidemiological research,Case report
376,"Fleming-Dutra, MMWR Morb Mortal Wkly Rep, 2016",Fleming-Dutra,"Fleming-Dutra, K. E., Nelson, J. M., Fischer, M., Staples, J. E., Karwowski, M. P., Mead, P., Villanueva, J., Renquist, C. M., Minta, A. A., Jamieson, D. J., Honein, M. A., Moore, C. A., Rasmussen, S. A.","Update: Interim Guidelines for Health Care Providers Caring for Infants and Children with Possible Zika Virus Infection - United States, February 2016",MMWR Morb Mortal Wkly Rep,65,7,182-7,2016,2010-present,February 26, 2016,26914500,10.15585/mmwr.mm6507e1,1238,English,,,,,,,,"CDC has updated its interim guidelines for U.S. health care providers caring for infants born to mothers who traveled to or resided in areas with Zika virus transmission during pregnancy and expanded guidelines to include infants and children with possible acute Zika virus disease (1). This update contains a new recommendation for routine care for infants born to mothers who traveled to or resided in areas with Zika virus transmission during pregnancy but did not receive Zika virus testing, when the infant has a normal head circumference, normal prenatal and postnatal ultrasounds (if performed), and normal physical examination. Acute Zika virus disease should be suspected in an infant or child aged <18 years who 1) traveled to or resided in an affected area within the past 2 weeks and 2) has >/=2 of the following manifestations: fever, rash, conjunctivitis, or arthralgia. Because maternal-infant transmission of Zika virus during delivery is possible, acute Zika virus disease should also be suspected in an infant during the first 2 weeks of life 1) whose mother traveled to or resided in an affected area within 2 weeks of delivery and 2) who has >/=2 of the following manifestations: fever, rash, conjunctivitis, or arthralgia. Evidence suggests that Zika virus illness in children is usually mild (2). As an arboviral disease, Zika virus disease is nationally notifiable. Health care providers should report suspected cases of Zika virus disease to their local, state, or territorial health departments to arrange testing and so that action can be taken to reduce the risk for local Zika virus transmission. As new information becomes available, these guidelines will be updated: http://www.cdc.gov/zika/.",Pubmed,March 31, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,No,Original research,No,Yes,376,Clinical/epidemiological research,Guidelines
377,"Maurice, Lancet, 2016",Maurice,"Maurice, J.",WHO reveals its shopping list for weapons against Zika,Lancet,387,10020,733,2016,2010-present,February 26, 2016,26913304,,1240,English,,,,,,,"Disease Outbreaks/prevention & control, Humans, Viral Vaccines, *World Health Organization, Zika Virus/immunology, Zika Virus Infection/epidemiology/*prevention & control/transmission",,Pubmed,March 31, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",News item or lay press,,,No,Yes,377,,
378,"Lupton, Br J Nurs, 2016",Lupton,"Lupton, K.",Zika virus disease: a public health emergency of international concern,Br J Nurs,25,4,"198, 200-2",2016,2010-present,February 26, 2016,26911164,10.12968/bjon.2016.25.4.198,1247,English,,"Registered Nurse, Queen Alexandra Hospital, Portsmouth Hospitals Trust.",,,,,"Blood safety, Global health, Pregnant women, Public health, World Health Organization, Zika virus","The emergence of Zika virus disease (ZIKV) in the Americas, mainly Brazil, has required the World Health Organization to take action to halt the spread of the virus by implementing preventive measures. This has resulted in increased surveillance of the virus and its potential complications. In the UK, cases of ZIKV have been reported in returning travellers. With the importance of this disease increasing, it is vital that nurses and other health professionals take the time to learn about ZIKV in order to pass on this knowledge to patients, enabling them to make informed choices about travel to affected areas. This article will discuss the ZIKV, its complications and what to advise travellers, including pregnant women, to prevent transmission and spread.",Pubmed,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,378,,
379,"Sarno, PLoS Negl Trop Dis, 2016",Sarno,"Sarno, M., Sacramento, G. A., Khouri, R., do Rosario, M. S., Costa, F., Archanjo, G., Santos, L. A., Nery, N., Jr., Vasilakis, N., Ko, A. I., de Almeida, A. R.","Zika Virus Infection and Stillbirths: A Case of Hydrops Fetalis, Hydranencephaly and Fetal Demise",PLoS Negl Trop Dis,10,2,e0004517,2016,2010-present,February 26, 2016,26914330,10.1371/journal.pntd.0004517,1239,English,,"Hospital Geral Roberto Santos, Secretaria Estadual da Saude da Bahia, Salvador, Bahia, Brazil., Faculdade de Medicina da Bahia and Instituto da Saude Coletiva, Universidade Federal da Bahia, Salvador, Bahia, Brazil., Centro de Pesquisas Goncalo Moniz, Fundacao Oswaldo Cruz, Ministerio da Saude, Salvador, Bahia, Brazil., Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, Connecticut, United States of America., Department of Pathology and Center of Biodefense and Emerging Infectious Diseases, Institute for Human Infections and Immunity, The University of Texas Medical Branch, Galveston, Texas, United States of America.",Brazil,Americas,Brazil,No funding received,,"BACKGROUND: The rapid spread of Zika virus in the Americas and current outbreak of microcephaly in Brazil has raised attention to the possible deleterious effects that the virus may have on fetuses. METHODOLOGY/PRINCIPAL FINDINGS: We report a case of a 20-year-old pregnant woman who was referred to our service after a large Zika virus outbreak in the city of Salvador, Brazil with an ultrasound examination that showed intrauterine growth retardation of the fetus at the 18th gestational week. Ultrasound examinations in the 2nd and 3rd trimesters demonstrated severe microcephaly, hydranencephaly, intracranial calcifications and destructive lesions of posterior fossa, in addition to hydrothorax, ascites and subcutaneous edema. An induced labor was performed at the 32nd gestational week due to fetal demise and delivered a female fetus. ZIKV-specific real-time polymerase chain reaction amplification products were obtained from extracts of cerebral cortex, medulla oblongata and cerebrospinal and amniotic fluid, while extracts of heart, lung, liver, vitreous body of the eye and placenta did not yield detectable products. CONCLUSIONS/SIGNIFICANCE: This case report provides evidence that in addition to microcephaly, there may be a link between Zika virus infection and hydrops fetalis and fetal demise. Given the recent spread of the virus, systematic investigation of spontaneous abortions and stillbirths may be warranted to evaluate the risk that ZIKV infection imparts on these outcomes.",Pubmed,March 31, 2016,Yes,,Yes,,Scientific (journal) article,Yes,Original research,No,Yes,379,Clinical/epidemiological research,Case report
380,"Palomo, J Public Health Policy, 2016",Palomo,"Palomo, A. M.",Zika virus: An international emergency?,J Public Health Policy,,,,2016,2010-present,February 26, 2016,26911655,10.1057/jphp.2016.11,1246,English,,"Center for Advanced Studies, Molecular Pathogenesis, Avenida IPN 2508, Mexico City (D.F.) 01030, Mexico. E-mail: amartine@cinvestav.mx.",,,,,,"This Viewpoint discusses the World Health Organization's Declaration on 1 February 2016 that the epidemic infection caused by the Zika virus is a public health emergency of international concern - the basis of the decision and controversy surrounding it.Journal of Public Health Policy advance online publication, 25 February 2016; doi:10.1057/jphp.2016.11.",Pubmed,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,No,Comment/Editorial/Perspective/Letter,No,Yes,380,,
381,"Jansen van Vuren, S Afr Med J, 2016",Jansen van Vuren,"Jansen van Vuren, P.; Weyer, J.; Kemp, A.; Dermaux-Msimang, V.; McCarthy, K.; Blumberg, L.; Paweska, J.",Is South Africa at risk for Zika virus disease?,S Afr Med J,106,3,232-3,2016,2010-present,February 27, 2016,26915933,10.7196/SAMJ.2016.v106i3.10615,1233,English,http://www.ncbi.nlm.nih.gov/pubmed/26915933,"Centre for Emerging and Zoonotic Diseases, National Institute for Communicable Diseases, National Health Laboratory Service, Sandringham, Johannesburg, South Africa. petrusv@nicd.ac.za.",,,,,,,Pubmed,March 31, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,381,,
382,"Citrome, Int J Clin Pract, 2016",Citrome,"Citrome, L.",Zika and You,Int J Clin Pract,70,3,181-2,2016,2010-present,February 27, 2016,26918506,10.1111/ijcp.12793,1230,English,,"New York Medical College, Valhalla, NY, USA. citrome@cnsconsultant.com.",,,,,,,Pubmed,March 31, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,382,,
383,"Iacobucci, BMJ, 2016",Iacobucci,"Iacobucci, G.",Zika highlights need for ethical framework for developing vaccines for pregnant women,BMJ,352,,i1155,2016,2010-present,February 27, 2016,26917790,10.1136/bmj.i1155,1231,English,,The BMJ.,,,,,,,Pubmed,March 31, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",News item or lay press,,,No,Yes,383,,
384,"Burke, Br J Gen Pract, 2016",Burke,"Burke, R. M., Pandya, P., Nastouli, E., Gothard, P.","Zika virus infection during pregnancy: what, where, and why?",Br J Gen Pract,66,644,122-3,2016,2010-present,February 27, 2016,26917636,10.3399/bjgp16X683917,1232,English,,"Core Medical Trainee, Hospital for Tropical Diseases, London., University College London Hospitals, London., Clinical Lead in Virology, University College London Hospitals, London., Consultant Physician, Hospital for Tropical Diseases, London.",,,,,,,Pubmed,March 31, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,384,,
385,"Stein, Int J Clin Pract, 2016",Stein,"Stein, R. A.","Zika: where it has been, where it is going, and how to stop it",Int J Clin Pract,70,3,182-5,2016,2010-present,February 27, 2016,26918507,10.1111/ijcp.12792,1229,English,,"Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY, USA. richardastein@gmail.com., Department of Natural Sciences, La Guardia Community College, City University of New York, Queens, NY, USA. richardastein@gmail.com.",,,,,,,Pubmed,March 31, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,385,,
386,"Wikan, Asian Pac J Trop Med, 2016",Wikan,"Wikan, N.; Suputtamongkol, Y.; Yoksan, S.; Smith, D. R.; Auewarakul, P.",Immunological evidence of Zika virus transmission in Thailand,Asian Pac J Trop Med,9,2,141-4,2016,2010-present,February 28, 2016,26919943,10.1016/j.apjtm.2016.01.017,1228,English,http://www.ncbi.nlm.nih.gov/pubmed/26919943,"Institute of Molecular Biosciences, Mahidol University, Bangkok, Thailand.; Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.; Institute of Molecular Biosciences, Mahidol University, Bangkok, Thailand. Electronic address: duncan_r_smith@hotmail.com.",,,,,Emerging infectious diseases; Serosurvey; Thailand; Zika virus,"OBJECTIVE: To identify immunological evidence of Zika virus transmission in Thailand. METHODS: To undertake a preliminary serosurvey of possible exposure to Zika virus, 21 serum samples from cohort of acute undifferentiated fever patients were examined for immunoreactivity to Zika, Dengue, Japanese encephalitis and Chikungunya envelope antigens by Western blot analysis. RESULTS: Twenty of the 21 serum samples showed immunoreactivity to at least one of the antigens, with seven samples showing immunoreactivity to all antigens. Of particular note, two serum samples showed immunoreactivity only to Zika envelope antigen, with no immunoreactivity to other envelope antigens. CONCLUSIONS: This study presents the first evidence of Zika virus transmission in Thailand, although as yet the relationship between transmission and possible cases of Zika fever in Thailand requires further investigation.",Pubmed,March 31, 2016,Yes,,No,"Zika, indirect evidence or other topic",Scientific (journal) article,Yes,Original research,No,Yes,386,Clinical/epidemiological research,Cross-sectional study
387,"de, J Clin Virol, 2016",de,"de, M. Campos R., Cirne-Santos, C., Meira, G. L., Santos, L. L., de Meneses, M. D., Friedrich, J., Jansen, S., Ribeiro, M. S., da Cruz, I. C., Schmidt-Chanasit, J., Ferreira, D. F.",Prolonged detection of Zika virus RNA in urine samples during the ongoing Zika virus epidemic in Brazil,J Clin Virol,77,,69-70,2016,2010-present,February 28, 2016,26921737,10.1016/j.jcv.2016.02.009,1224,English,,"Microbiology Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil., Microbiology Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil; Noel Nutels Central Laboratory (LACEN), Rio de Janeiro, Brazil., Bernhard Nocht Institute for Tropical Medicine, WHO Collaborating Centre for Arbovirus and Haemorrhagic Fever Reference and Research, Hamburg, Germany., Noel Nutels Central Laboratory (LACEN), Rio de Janeiro, Brazil; Institute of Public Health, Federal University of Rio de Janeiro, Brazil., Noel Nutels Central Laboratory (LACEN), Rio de Janeiro, Brazil., Bernhard Nocht Institute for Tropical Medicine, Germany., Microbiology Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil. Electronic address: davisf@micro.ufrj.br.",,,,,,,Pubmed,March 31, 2016,Yes,,No,"Zika, not relevant to causality framework",Scientific (journal) article,Yes,Original research,No,Yes,387,Clinical/epidemiological research,Case series
388,"McCarthy, BMJ, 2016",McCarthy,"McCarthy, M.",US health officials investigate sexually transmitted Zika virus infections,BMJ,352,,i1180,2016,2010-present,February 28, 2016,26921165,10.1136/bmj.i1180,1226,English,,Seattle.,,,,,,,Pubmed,March 31, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",News item or lay press,,,No,Yes,388,,
389,"Basarab, BMJ, 2016",Basarab,"Basarab, M., Bowman, C., Aarons, E. J., Cropley, I.",Zika virus,BMJ,352,,i1049,2016,2010-present,February 28, 2016,26921241,10.1136/bmj.i1049,1225,English,,"Department of Infectious Diseases, Royal Free London NHS Foundation Trust, London NW3 2QG, UK., Rare and Imported Pathogens Laboratory, Public Health England, Porton Down, UK., Department of Infectious Diseases, Royal Free London NHS Foundation Trust, London NW3 2QG, UK iancropley@nhs.net.",,,,,,,Pubmed,March 31, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Yes,Review,No,Yes,389,Clinical/epidemiological research,Epidemiological/clinical review
390,"Ahmad, BMJ, 2016",Ahmad,"Ahmad, S. S.; Amin, T. N.; Ustianowski, A.",Zika virus: management of infection and risk,BMJ,352,,i1062,2016,2010-present,February 28, 2016,26920038,10.1136/bmj.i1062,1227,English,http://www.ncbi.nlm.nih.gov/pubmed/26920038,"Northwest Regional Infectious Diseases Unit, North Manchester General Hospital, Pennine Acute Hospitals Trust, Manchester M8 5RB, UK Virology Department, Manchester Royal Infirmary, Central Manchester Foundation Trust, Manchester Academic Health Sciences Centre, Manchester M13 9WL, UK.; Department of Obstetrics and Gynaecology, University College London Hospitals NHS Foundation Trust, London, UK.; Northwest Regional Infectious Diseases Unit, North Manchester General Hospital, Pennine Acute Hospitals Trust, Manchester M8 5RB, UK Andrew.Ustianowski@pat.nhs.uk.",,,,,,,Pubmed,March 31, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Yes,Other,No,Yes,390,,
391,"Shakir, Lancet Neurol, 2016",Shakir,"Shakir, R.",Neurological expertise is essential for Zika virus infection,Lancet Neurol,15,4,353-4,2016,2010-present,February 29, 2016,26922438,10.1016/S1474-4422(16)00072-7,1221,English,http://www.ncbi.nlm.nih.gov/pubmed/26922438,"Imperial College, Charing Cross Hospital, London, W6 8RF, UK. Electronic address: r.shakir@imperial.ac.uk.",,,,,,,Pubmed,March 31, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,391,,
392,"Byass, Lancet, 2016",Byass,"Byass, P., Wilder-Smith, A.",Utilising additional sources of information on microcephaly,Lancet,387,10022,940-1,2016,2010-present,February 29, 2016,26921912,10.1016/s0140-6736(16)00519-5,1223,English,,"WHO Collaborating Centre for Verbal Autopsy, Epidemiology and Global Health, Umea University, Umea 90187, Sweden. Electronic address: peter.byass@umu.se., WHO Collaborating Centre for Verbal Autopsy, Epidemiology and Global Health, Umea University, Umea 90187, Sweden; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore.",,,,,"Brazil/epidemiology, *Disease Outbreaks, Humans, Microcephaly/diagnosis/*epidemiology/*virology, Zika Virus Infection/diagnosis/*epidemiology",,Pubmed,March 31, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,392,,
393,"Barreto, Lancet, 2016",Barreto,"Barreto, M. L., Barral-Netto, M., Stabeli, R., Almeida-Filho, N., Vasconcelos, P. F., Teixeira, M., Buss, P., Gadelha, P. E.",Zika virus and microcephaly in Brazil: a scientific agenda,Lancet,387,10022,919-21,2016,2010-present,February 29, 2016,26921913,10.1016/s0140-6736(16)00545-6,1222,English,,"Centro de Pesquisas Goncalo Moniz, Fundacao Oswaldo Cruz, 40296-710 Salvador-Bahia, Brazil. Electronic address: mauricio.barreto@bahia.fiocruz.br., Centro de Pesquisas Goncalo Moniz, Fundacao Oswaldo Cruz, 40296-710 Salvador-Bahia, Brazil., Office of the Presidency, Fundacao Oswaldo Cruz, Rio de Janeiro, Brazil., Universidade Federal do Sul da Bahia, Itabuna, Brazil., Department of Arbovirology and Hemorrhagic Fevers, Instituto Evandro Chagas, Ananindeua, Brazil., Department of Biochemistry and Immunology, Universidade Federal de Minas Gerais, Minas Gerais, Brazil., Center for International Relations in Health, Fundacao Oswaldo Cruz, Rio de Janeiro, Brazil.",,,,,"*Biomedical Research, Brazil/epidemiology, *Health Policy, Humans, Microcephaly/epidemiology/*prevention & control/*virology, *Zika Virus, Zika Virus Infection/epidemiology/*prevention & control",,Pubmed,March 31, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,393,,
394,"The Lancet, Lancet Neurol, 2016",The Lancet,"The Lancet, Neurology","Zika virus: a little less speculation, a little more action",Lancet Neurol,15,4,343,2016,2010-present,February 29, 2016,26922439,10.1016/s1474-4422(16)00074-0,1220,English,,,,,,,,,Pubmed,March 31, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,394,,
395,"Werner, Ultrasound Obstet Gynecol, 2016",Werner,"Werner, H.; Fazecas, T.; Guedes, B.; Dos Santos, J. L.; Daltro, P.; Tonni, G.; Campbell, S.; Araujo Junior, E.",Intrauterine Zika virus infection and microcephaly: perinatal imaging correlations with 3D virtual physical models,Ultrasound Obstet Gynecol,,,,2016,2010-present,March 1, 2016,26923098,10.1002/uog.15901,1218,English,http://www.ncbi.nlm.nih.gov/pubmed/26923098,"Department of Radiology, Clinica de Diagnostico por Imagem (CPDI), Rio de Janeiro, RJ, Brazil.; Department of Arts and Design, Pontificia Universidade Catolica (PUC Rio), Rio de Janeiro-RJ, Brazil.; Department of Obstetrics and Gynecology, Guastalla Civil Hospital, AUSL Reggio Emilia, Italy.; Create Health Clinic, London, UK.; Department of Obstetrics, Paulista School of Medicine, Federal University of Sao Paulo (EPM-UNIFESP), Sao Paulo-SP, Brazil.",Brazil,Americas,Brazil,Not reported/unknown,3D virtual physical model; Computed tomography; Intrauterine infection; Magnetic resonance imaging; Microcephaly; Ultrasound; Zika virus,"Zika virus (ZIKV) belongs to the same family of fla-  viviruses as dengue and chikungunya. A dramatic surge in birth defects, particularly of fetuses and newborns with microcephaly, has been reported  recently in Brazil. The article reports imaging findings in a 27-year-old primigravida who was referred ad 12 weeks of gestation for symptoms of ZIKV infection. First and second trimester ultrasound showed normal fetal anatomy. In Ultrasound at 37 weeks of gestation microcephaly was suspected and confirmed with an MRI. Postnatal 3D CT enabled reconstruction of microcephaly and enhanced the partents understanding of the disease.",Pubmed,March 31, 2016,Yes,,Yes,,Scientific (journal) article,Yes,Original research,No,Yes,395,Clinical/epidemiological research,Case report
396,"Nishiura, Int J Infect Dis, 2016",Nishiura,"Nishiura, H., Kinoshita, R., Mizumoto, K., Yasuda, Y., Nah, K.",Transmission potential of Zika virus infection in the South Pacific,Int J Infect Dis,45,,95-97,2016,2010-present,March 1, 2016,26923081,10.1016/j.ijid.2016.02.017,1219,English,,"Graduate School of Medicine, Hokkaido University, Kita 15 Jo Nishi 7 Chome, Kita-ku, Sapporo-shi, Hokkaido 060-8638, Japan; CREST, Japan Science and Technology Agency, Kawaguchi, Saitama, Japan; Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, 1130033, Japan. Electronic address: nishiurah@gmail.com., Graduate School of Medicine, Hokkaido University, Kita 15 Jo Nishi 7 Chome, Kita-ku, Sapporo-shi, Hokkaido 060-8638, Japan; CREST, Japan Science and Technology Agency, Kawaguchi, Saitama, Japan; Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, 1130033, Japan., Graduate School of Medicine, Hokkaido University, Kita 15 Jo Nishi 7 Chome, Kita-ku, Sapporo-shi, Hokkaido 060-8638, Japan; Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, 1130033, Japan; Graduate School of Arts and Sciences, The University of Tokyo, Meguro-ku, Tokyo, Japan., Graduate School of Medicine, Hokkaido University, Kita 15 Jo Nishi 7 Chome, Kita-ku, Sapporo-shi, Hokkaido 060-8638, Japan.",,,,,"Basic reproduction number, Epidemic, Statistical estimation, Transmissibility, Zika virus","OBJECTIVES: Zika virus has spread internationally through countries in the South Pacific and Americas. The present study aimed to estimate the basic reproduction number, R0, of Zika virus infection as a measurement of the transmission potential, reanalyzing past epidemic data from the South Pacific. METHODS: Incidence data from two epidemics, one on Yap Island, Federal State of Micronesia in 2007 and the other in French Polynesia in 2013-2014, were reanalyzed. R0 of Zika virus infection was estimated from the early exponential growth rate of these two epidemics. RESULTS: The maximum likelihood estimate (MLE) of R0 for the Yap Island epidemic was in the order of 4.3-5.8 with broad uncertainty bounds due to the small sample size of confirmed and probable cases. The MLE of R0 for French Polynesia based on syndromic data ranged from 1.8 to 2.0 with narrow uncertainty bounds. CONCLUSIONS: The transmissibility of Zika virus infection appears to be comparable to those of dengue and chikungunya viruses. Considering that Aedes species are a shared vector, this finding indicates that Zika virus replication within the vector is perhaps comparable to dengue and chikungunya.",Pubmed,March 31, 2016,Yes,,No,"Zika, not relevant to causality framework",Scientific (journal) article,Yes,Original research,No,Yes,396,Clinical/epidemiological research,Modelling study
397,"Solomon, Lancet Infect Dis, 2016",Solomon,"Solomon, T., Baylis, M., Brown, D.",Zika virus and neurological disease-approaches to the unknown,Lancet Infect Dis,,,,2016,2010-present,March 1, 2016,26923117,10.1016/s1473-3099(16)00125-0,1217,English,,"Institute of Infection and Global Health, University of Liverpool, L69 7BE, UK; Walton Centre NHS Foundation Trust, Liverpool, UK; National Institute for Health Research Health Protection Research Unit in Emerging and Zoonotic Infections, Liverpool, UK. Electronic address: tsolomon@liv.ac.uk., Institute of Infection and Global Health, University of Liverpool, L69 7BE, UK; National Institute for Health Research Health Protection Research Unit in Emerging and Zoonotic Infections, Liverpool, UK., National Institute for Health Research Health Protection Research Unit in Emerging and Zoonotic Infections, Liverpool, UK; Influenza Laboratory, Oswaldo Cruz Institute/Fiocruz, Rio de Janeiro, Brazil; Virus Reference Department, National Infection Service, Public Health England, UK.",,,,,,,Pubmed,March 31, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,397,,
398,"Chang, J Autoimmun, 2016",Chang,"Chang, C., Ortiz, K., Ansari, A., Gershwin, M. E.",The Zika outbreak of the 21st century,J Autoimmun,68,,Jan 13,2016,2010-present,March 2, 2016,26925496,10.1016/j.jaut.2016.02.006,1216,English,,"Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis School of Medicine, Davis, CA, USA., Departmenty of Pathology, Emory University School of Medicine, Atlanta, GA, USA., Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis School of Medicine, Davis, CA, USA. Electronic address: megershwin@ucdavis.edu.",,,,,"Aedes aegypti, Arborvirus, Autophagy, Centrosome, Dengue, Flavivirus, Glycosylation, Guillain-Barre, Microcephaly, Mosquitoes, Pandemic, Sexual transmission, Zika fever","The Zika virus outbreak has captivated the attention of the global audience and information has spread rapidly and wildly through the internet and other media channels. This virus was first identified in 1947, when it was isolated from a sentinel rhesus monkey placed by British scientists working at the Yellow Fever Research Laboratory located in the Zika forest area of Uganda, hence its name, and is transmitted primarily by the mosquito vector, Aedes aegypti. The fact that the rhesus macaque is an Asian species being placed in an African forest brings to mind the possibility of rapid adaptation of the virus from an African to Asian species, an issue that has not been considered. Whether such adaptation has played any role in acquiring pathogenicity due to cross species transmission remains to be identified. The first human infection was described in Nigeria in 1954, with only scattered reports of about a dozen human infections identified over a 50-year period. It was not until 2007 that Zika virus raised its ugly head with infections noted in three-quarters of the population on the tiny island of Yap located between the Philippines and Papua New Guinea in the western Pacific Ocean, followed by a major outbreak in French Polynesia in 2013. The virus remained confined to a narrow equatorial band in Africa and Asia until 2014 when it began to spread eastward, first toward Oceania and then to South America. Since then, millions of infected individuals have been identified in Brazil, Colombia, Venezuela, including 25 additional countries in the Americas. While the symptoms associated with Zika virus infection are generally mild, consisting of fever, maculopapular rash, arthralgia and conjunctivitis, there have been reports of more severe reactions that are associated with neurological complications. In pregnant women, fetal neurological complications include brain damage and microcephaly, while in adults there have been several cases of virus-associated Guillain-Barre syndrome. The virus was until recently believed to only be transmitted via mosquitoes. But when the Zika virus was isolated from the semen specimens from a patient in Texas, this provided the basis for the recent report of possible sexual transmission of the Zika virus. Due to the neurological complications, various vectors for infection as well as the rapid spread throughout the globe, it has prompted the World Health Organization to issue a global health emergency. Various governmental organizations have recommended that pregnant women do not travel to countries where the virus is epidemic, and within the countries affected by the virus, recommendations were provided for women of childbearing age to delay pregnancy. The overall public health impact of these above findings highlights the need for a rapid but specific diagnostic test for blood banks worldwide to identify those infected and for the counseling of women who are pregnant or contemplating pregnancy. As of this date, there are neither commercially licensed diagnostic tests nor a vaccine. Because cross-reactivity of the Zika virus with dengue and Chikungunya virus is common, it may pose difficulty in being able to quickly develop such tests and vaccines. So far the most effective public health measures include controlling the mosquito populations via insecticides and preventing humans from direct exposure to mosquitoes.",Pubmed,March 31, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Yes,Review,No,Yes,398,Clinical/epidemiological research,Epidemiological/clinical review
399,"McCarthy, BMJ, 2016",McCarthy,"McCarthy, M.",Zika cases climb to 147 in US and Puerto Rico,BMJ,352,,i1212,2016,2010-present,March 2, 2016,26927301,10.1136/bmj.i1212,1215,English,,Seattle.,,,,,,,Pubmed,March 31, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",News item or lay press,,,No,Yes,399,,
400,"Heukelbach, J Infect Dev Ctries, 2016",Heukelbach,"Heukelbach, J., Alencar, C. H., Kelvin, A. A., De Oliveira, W. K., Pamplona de Goes Cavalcanti, L.",Zika virus outbreak in Brazil,J Infect Dev Ctries,10,2,116-20,2016,2010-present,March 2, 2016,26927450,10.3855/jidc.8217,1213,English,,"School of Medicine, Federal University of Ceara, Fortaleza, CE, Brazil. heukelbach@web.de.",,,,,,"Zika virus (ZIKV) infection is spreading rapidly within the Americas after originating from an outbreak in Brazil. We describe the current ZIKV infection epidemic in Brazil and the neurological symptoms arising. First cases of an acute exanthematic disease were reported in Brazil's Northeast region at the end of 2014. In March 2015, autochthonous ZIKV was determined to be the causative agent of the exanthematic disease. As cases of neurological syndromes in regions where ZIKV, dengue and/or Chikungunya viruses co-circulate were reported, ZIKV was also identified in the cerebrospinal fluid of patients with acute neurological syndromes and previous exanthematic disease. By the end of September 2015, an increasing number of infants with small head circumference or microcephaly were noted in Brazil's Northeast which was estimated to be 29 cases between August and October. ZIKV was identified in blood and tissue samples of a newborn and in mothers who had given birth to infants with microcephaly and ophthalmological anomalies. In 2015, there were an estimated 440,000 - 1,300,000 Zika cases in Brazil. There have been 4,783 suspected cases of microcephaly, most of them in the Northeast of Brazil associated with 76 deaths. The Ministry of Health is intensifying control measures against the mosquito Aedes aegypti and implemented intensive surveillance actions. Further studies are needed to confirm the suspected association between ZIKV infection and microcephaly; to identify antiviral, immunotherapy, or prophylactic vaccine; to introduce diagnostic ELISA testing. Clinical and epidemiological studies must be performed to describe viral dynamics and expansion of the outbreak.",Pubmed,March 31, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Yes,Review,No,Yes,400,Clinical/epidemiological research,Epidemiological/clinical review
401,"Killion, MCN Am J Matern Child Nurs, 2016",Killion,"Killion, M. M.",Zika Virus Update,MCN Am J Matern Child Nurs,,,,2016,2010-present,March 2, 2016,26927699,10.1097/nmc.0000000000000246,1212,English,,"Molly Killion is a Perinatal Clinical Nurse Specialist, Birth Center, University of California San Francisco Benioff Children's Hospital in San Francisco, CA. She can be reached via email at molly.killion@ucsf.edu.",,,,,,,Pubmed,March 31, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,401,,
402,"Kelvin, J Infect Dev Ctries, 2016",Kelvin,"Kelvin, A. A.; Banner, D.; Pamplona, L.; Alencar, C.; Rubino, S.; Heukelbach, J.",ZIKATracker: A mobile App for reporting cases of ZIKV worldwide,J Infect Dev Ctries,10,2,113-5,2016,2010-present,March 2, 2016,26927449,10.3855/jidc.8248,1214,English,http://www.ncbi.nlm.nih.gov/pubmed/26927449,"Immune Diagnostics and Research (IDR), Toronto, Ontario, Canada. akelvinphd@jidc.org.",,,,,,"We have developed a mobile App called ZIKATracker (zikatracker.net) to voluntarily be used to report ZIKV cases on a public or private level. As the Zika virus (ZIKV) infection zones are rapidly expanding across South, Central, and North America, and reports have emerged linking ZIKV infection with developmental defects and neurological sequelae, reporting the movement and sequelae of ZIKV is essential. ZIKATracker is a multi-lingual App (English, French, Spanish, and Portuguese) freely available to anyone worldwide wishing to report a suspected or confirmed case of Zika virus and related symptoms. Knowledge gained from the use of this App will help direct the implementation of mosquito control measures in needed areas, bring aid to those affected by the Zika virus, and understand the movement and sequelae of ZIKV as it spreads through communities and across continents.",Pubmed,March 31, 2016,Yes,,No,"Zika, not relevant to causality framework",Scientific (journal) article,Yes,Other,No,Yes,402,,
403,"Kantor, Medicina (B Aires), 2016",Kantor,"Kantor, I. N.","[Dengue, Zika and Chikungunya]",Medicina (B Aires),,,,2016,2010-present,March 5, 2016,26942903,,1195,Spanish,http://www.ncbi.nlm.nih.gov/pubmed/26942903,"Comite de Redaccion, Medicina (Buenos Aires), Buenos Aires, Argentina. E-mail: isabel.kantor@gmail.com.",,,,,Argentina; arbovirus; chikungunya; dengue; zika,"Arboviruses are transmitted by arthropods, including those responsible for the current pandemic: alphavirus (Chikungunya) and flaviviruses (dengue and Zika). Its importance increased in the Americas over the past 20 years. The main vectors are Aedes aegypti and A. albopictus. Dengue infection provides long lasting immunity against the specific serotype and temporary to the other three. Subsequent infection by another serotype determines more serious disease. There is a registered vaccine for dengue, Dengvaxia (Sanofi Pasteur). Other two (Butantan and Takeda) are in Phase III in 2016. Zika infection is usually asymptomatic or occurs with rash, conjunctivitis and not very high fever. There is no vaccine or specific treatment. It can be transmitted by parental, sexual and via blood transfusion. It has been associated with microcephaly. Chikungunya causes prolonged joint pain and persistent immune response. Two candidate vaccines are in Phase II. Dengue direct diagnosis is performed by virus isolation, RT-PCR and ELISA for NS1 antigen detection; indirect methods are ELISA-IgM (cross-reacting with other flavivirus), MAC-ELISA, and plaque neutralization. Zika is diagnosed by RT-PCR and virus isolation. Serological diagnosis cross-reacts with other flavivirus. For CHIKV culture, RT-PCR, MAC-ELISA and plaque neutralization are used. Against Aedes organophosphate larvicides (temephos), organophosphorus insecticides (malathion and fenitrothion) and pyrethroids (permethrin and deltamethrin) are usually employed. Resistance has been described to all these products. Vegetable derivatives are less expensive and biodegradable, including citronella oil, which microencapsulated can be preserved from evaporation.",Pubmed,March 31, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Yes,Review,No,Yes,403,Clinical/epidemiological research,Epidemiological/clinical review
404,"Venturi, Eurosurveillance, 2016",Venturi,"Venturi, G.; Zammarchi, L.; Fortuna, C.; Remoli, M. E.; Benedetti, E.; Fiorentini, C.; Trotta, M.; Rizzo, C.; Mantella, A.; Rezza, G.; Bartoloni, A.","An autochthonous case of Zika due to possible sexual transmission, Florence, Italy, 2014",Eurosurveillance,21,8,,2016,2010-present,March 5, 2016,26939607,10.2807/1560-7917.ES.2016.21.8.30148,1201,English,http://www.ncbi.nlm.nih.gov/pubmed/26939607,"Department of Infectious, Parasitic and Immune-Mediate Diseases, Istituto Superiore di Sanita, Rome, Italy.",,,,,Europe; Italy; Zika virus; autochthonous; semen; sexual transmission,"We report a case of Zika virus infection imported in Florence, Italy ex-Thailand, leading to a secondary autochthonous case, probably through sexual transmission. The two cases occurred in May 2014 but were retrospectively diagnosed in 2016 on the basis of serological tests (plaque reduction neutralisation) performed on stored serum samples. Our report provides further evidence that sexual transmission of Zika virus is possible.",Pubmed,March 31, 2016,Yes,,No,"Zika, not relevant to causality framework",Scientific (journal) article,Yes,Original research,Yes,No,205,Clinical/epidemiological research,Case report
405,"Hennigan, BMJ, 2016",Hennigan,"Hennigan, T.",Brazil struggles to cope with Zika epidemic,BMJ,352,,i1226,2016,2010-present,March 5, 2016,26931360,10.1136/bmj.i1226,1211,English,http://www.ncbi.nlm.nih.gov/pubmed/26931360,"Sao Paulo, Brazil.",,,,,,,Pubmed,March 31, 2016,Yes,,No,"Zika, not relevant to causality framework",News item or lay press,,,No,Yes,405,,
406,"Benelli, Parasitol Res, 2016",Benelli,"Benelli, G.; Mehlhorn, H.","Declining malaria, rising of dengue and Zika virus: insights for mosquito vector control",Parasitol Res,,,,2016,2010-present,March 5, 2016,26932263,10.1007/s00436-016-4971-z,1210,English,http://www.ncbi.nlm.nih.gov/pubmed/26932263,"Insect Behaviour Group, Department of Agriculture, Food and Environment, University of Pisa, via del Borghetto 80, 56124, Pisa, Italy. g.benelli@sssup.it.; Department of Parasitology, Heinrich Heine University, Dusseldorf, Germany.",,,,,Arbovirus; Artemisinin; Biological control; Boosted SIT; Nanosynthesis; Sex pheromones; Sound traps; Sterile insect technique; Swarming behaviour; Vaccine,"The fight against mosquito-borne diseases is a challenge of huge public health importance. To our mind, 2015 was an extraordinary year for malaria control, due to three hot news: the Nobel Prize to Youyou Tu for the discovery of artemisinin, the development of the first vaccine against Plasmodium falciparum malaria [i.e. RTS,S/AS01 (RTS,S)], and the fall of malaria infection rates worldwide, with special reference to sub-Saharan Africa. However, there are major challenges that still deserve attention, in order to boost malaria prevention and control. Indeed, parasite strains resistant to artemisinin have been detected, and RTS,S vaccine does not offer protection against Plasmodium vivax malaria, which predominates in many countries outside of Africa. Furthermore, the recent outbreaks of Zika virus infections, occurring in South America, Central America and the Caribbean, represent the most recent of four arrivals of important arboviruses in the Western Hemisphere, over the last 20 years. Zika virus follows dengue (which slyly arrived in the hemisphere over decades and became more aggressive in the 1990s), West Nile virus (emerged in 1999) and chikungunya (emerged in 2013). Notably, there are no specific treatments for these arboviruses. The emerging scenario highlights that the effective and eco-friendly control of mosquito vectors, with special reference to highly invasive species such as Aedes aegypti and Aedes albopictus, is crucial. The concrete potential of screening plant species as sources of metabolites for parasitological purposes is worthy of attention, as elucidated by the Y. Tu's example. Notably, plant-borne molecules are often effective at few parts per million against Aedes, Ochlerotatus, Anopheles and Culex young instars, can be used for the rapid synthesis of mosquitocidal nanoformulations and even employed to prepare cheap repellents with low human toxicity. In addition, behaviour-based control tools relying to the employ of sound traps and the manipulation of swarming behaviour (i.e. 'lure and kill' approach) are discussed. The importance of further research on the chemical cues routing mosquito swarming and mating dynamics is highlighted. Besides radiation, transgenic and symbiont-based mosquito control approaches, an effective option may be the employ of biological control agents of mosquito young instars, in the presence of ultra-low quantities of nanoformulated botanicals, which boost their predation rates.",Pubmed,March 31, 2016,Yes,,No,"Zika, not relevant to causality framework",Scientific (journal) article,Yes,Review,No,Yes,406,Environmental and vector research,Ecological/Vector review
407,"Chouin-Carneiro, PLoS Negl Trop Dis, 2016",Chouin-Carneiro,"Chouin-Carneiro, T.; Vega-Rua, A.; Vazeille, M.; Yebakima, A.; Girod, R.; Goindin, D.; Dupont-Rouzeyrol, M.; Lourenco-de-Oliveira, R.; Failloux, A. B.",Differential Susceptibilities of Aedes aegypti and Aedes albopictus from the Americas to Zika Virus,PLoS Negl Trop Dis,10,3,e0004543,2016,2010-present,March 5, 2016,26938868,10.1371/journal.pntd.0004543,1203,English,http://www.ncbi.nlm.nih.gov/pubmed/26938868,"Instituto Oswaldo Cruz, Rio de Janeiro, Brazil.; Institut Pasteur, Arboviruses and Insect Vectors, Paris, France.; Centre de Demoustication/Collectivite Territoriale de La Martinique, Fort-de-France, Martinique.; Institut Pasteur of French Guiana, Unit of Medical Entomology, Cayenne, French Guiana.; Institut Pasteur of Guadeloupe, Laboratory of Medical Entomology, Environment and Health, Les Abymes, Guadeloupe.; Institut Pasteur of New Caledonia, Dengue and Arboviruses Research and Expertise Unit, Noumea, New Caledonia.",,,,,,"BACKGROUND: Since the major outbreak in 2007 in the Yap Island, Zika virus (ZIKV) causing dengue-like syndromes has affected multiple islands of the South Pacific region. In May 2015, the virus was detected in Brazil and then spread through South and Central America. In December 2015, ZIKV was detected in French Guiana and Martinique. The aim of the study was to evaluate the vector competence of the mosquito spp. Aedes aegypti and Aedes albopictus from the Caribbean (Martinique, Guadeloupe), North America (southern United States), South America (Brazil, French Guiana) for the currently circulating Asian genotype of ZIKV isolated from a patient in April 2014 in New Caledonia. METHODOLOGY/PRINCIPAL FINDINGS: Mosquitoes were orally exposed to an Asian genotype of ZIKV (NC-2014-5132). Upon exposure, engorged mosquitoes were maintained at 28 degrees +/-1 degrees C, a 16h:8h light:dark cycle and 80% humidity. 25-30 mosquitoes were processed at 4, 7 and 14 days post-infection (dpi). Mosquito bodies (thorax and abdomen), heads and saliva were analyzed to measure infection, dissemination and transmission, respectively. High infection but lower disseminated infection and transmission rates were observed for both Ae. aegypti and Ae. albopictus. Ae. aegypti populations from Guadeloupe and French Guiana exhibited a higher dissemination of ZIKV than the other Ae. aegypti populations examined. Transmission of ZIKV was observed in both mosquito species at 14 dpi but at a low level. CONCLUSIONS/SIGNIFICANCE: This study suggests that although susceptible to infection, Ae. aegypti and Ae. albopictus were unexpectedly low competent vectors for ZIKV. This may suggest that other factors such as the large naive population for ZIKV and the high densities of human-biting mosquitoes contribute to the rapid spread of ZIKV during the current outbreak.",Pubmed,March 31, 2016,Yes,,No,"Zika, not relevant to causality framework",Scientific (journal) article,Yes,Original research,No,Yes,407,Environmental and vector research,Vector competence studies
408,"Cunha, Genome Announc, 2016",Cunha,"Cunha, M. S.; Esposito, D. L.; Rocco, I. M.; Maeda, A. Y.; Vasami, F. G.; Nogueira, J. S.; de Souza, R. P.; Suzuki, A.; Addas-Carvalho, M.; Barjas-Castro Mde, L.; Resende, M. R.; Stucchi, R. S.; Boin Ide, F.; Katz, G.; Angerami, R. N.; da Fonseca, B. A.","First Complete Genome Sequence of Zika Virus (Flaviviridae, Flavivirus) from an Autochthonous Transmission in Brazil",Genome Announc,4,2,,2016,2010-present,March 5, 2016,26941134,10.1128/genomeA.00032-16,1196,English,http://www.ncbi.nlm.nih.gov/pubmed/26941134,"Division of Vector-Borne Diseases, Adolfo Lutz Institute, Sao Paulo, Brazil.; Department of Internal Medicine, Division of Infectious Diseases, School of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil.; Blood Center, State University of Campinas/UNICAMP, Campinas, Sao Paulo, Brazil.; Section of Hospital Epidemiology, Hospital of Clinics, State University of Campinas/UNICAMP, Campinas, Sao Paulo, Brazil.; Clinical Medical Department, Faculty of Medical Sciences, State University of Campinas/UNICAMP, Campinas, Sao Paulo, Brazil.; Infectious Diseases Surveillance Center 'Prof. Alexandre Vranjac'/CCD, Sao Paulo, Sao Paulo, Brazil.; Department of Internal Medicine, Division of Infectious Diseases, School of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil baldfons@fmrp.usp.br.",,,,,,"We report here the genome sequence of Zika virus, strain ZikaSPH2015, containing all structural and nonstructural proteins flanked by the 5' and 3' untranslated region. It was isolated in Sao Paulo state, Brazil, in 2015, from a patient who received a blood transfusion from an asymptomatic donor at the time of donation.",Pubmed,March 31, 2016,Yes,,No,"Zika, not relevant to causality framework",Scientific (journal) article,Yes,Original research,No,Yes,408,Basic and applied biomedical research,Sequence analysis and phylogenetics
409,"Becker, Nat Med, 2016",Becker,"Becker, R.",Missing link: Animal models to study whether Zika causes birth defects,Nat Med,22,3,225-7,2016,2010-present,March 5, 2016,26937612,10.1038/nm0316-225,1206,English,http://www.ncbi.nlm.nih.gov/pubmed/26937612,,,,,,,,Pubmed,March 31, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",News item or lay press,,,No,Yes,409,,
410,"Check Hayden, Nature, 2016",Check Hayden,"Check Hayden, E.",Spectre of Ebola haunts Zika response,Nature,531,7592,19,2016,2010-present,March 5, 2016,26935676,10.1038/531019a,1207,English,,,,,,,"Africa, Western/epidemiology, Brazil/epidemiology, Disease Outbreaks/statistics & numerical data, *Epidemiological Monitoring, *Global Health, Hemorrhagic Fever, Ebola/*epidemiology, Humans, Influenza A Virus, H1N1 Subtype, Influenza, Human/epidemiology, Information Dissemination, Microcephaly/complications/epidemiology, Public Health, World Health Organization/*organization & administration, *Zika Virus, Zika Virus Infection/*epidemiology/virology",,Pubmed,March 31, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",News item or lay press,,,No,Yes,410,,
411,"Wise, BMJ, 2016",Wise,"Wise, J.",Study links Zika virus to Guillain-Barre syndrome,BMJ,352,,i1242,2016,2010-present,March 5, 2016,26932976,10.1136/bmj.i1242,1209,English,http://www.ncbi.nlm.nih.gov/pubmed/26932976,London.,,,,,,,Pubmed,March 31, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",News item or lay press,,,No,Yes,411,,
412,"Burd, J Assist Reprod Genet, 2016",Burd,"Burd, I.; Griffin, D.",The chasm between public health and reproductive research: what history tells us about Zika virus,J Assist Reprod Genet,,,,2016,2010-present,March 5, 2016,26943916,10.1007/s10815-016-0687-3,1193,English,http://www.ncbi.nlm.nih.gov/pubmed/26943916,"Integrated Research Center for Fetal Medicine, Department of Gynecology and Obstetrics, Johns Hopkins School of Medicine, 600 N Wolfe Street, Phipps 228, Baltimore, MD, 21287, USA. iburd@jhmi.edu.; Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD, USA. iburd@jhmi.edu.; Molecular Biology and Immunology, Johns Hopkins School of Public Health, Baltimore, MD, USA.",,,,,Mother-to-child transmission; Sexual transmission virus in seminal fluid; Zika,"Zika transmission from mother to fetus and its possible sexual transmission have become a media focus in the past months as a major public health concern. While mother-to-fetus transmission, fetal neurologic manifestations or sexual transmission have never been documented for this virus before, other viruses that belong to the same family are very well known to reproductive health workers, clinicians, and researchers. As a member of Flaviviridae family, including hepatitis C and bovine viral diarrhea virus (BVDV), Zika's pathogenesis may have some parallels with these infections which may pose future questions for public health and research. Vertical transmission of hepatitis C virus from mother to child is known to occur in up to 10 % of pregnancies. BVDV, a member of Pestivirus genus of Flaviviridae family is not known to be transmitted to humans but is known for its vertical transmission in cattle. BVDV infection at different stages of gestation may lead to a spectrum of adverse pregnancy outcomes, including pregnancy loss and neurologic manifestations (including deformations such as hydrocephalus and microcephaly) in the offspring. Similar to hepatitis C, which is a virus of Hepacivirus genus, BVDV is capable of persistent infection, meaning that virus may stay in mother and future generations of calves may be infected as well, which may, in turn, result in persistence of infection in offspring. Would this be a case with Zika virus? Along with mother-to-fetus transmission, sexual transmission is a concerning implication for Zika virus. Would woman become a persistent career or male be able to persistently carry virus with its sperm is yet unknown; yet, there is a concern for the reservoir of infection. Animal models of the disease are urgently needed not only to demonstrate the mother-to-fetus transmission and confirm the fetal neurologic manifestations but also to address the effects of virus on life-long host's immunity and reproductive health. Along those lines, women desiring pregnancies who are identified to travel, have a partner traveling to, or living in the areas of Zika infections should be encouraged to have a preconception consultation with maternal-fetal medicine.",Pubmed,March 31, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,412,,
413,"Rodríguez-Morales, Ann Clin Microbiol Antimicrob, 2016",Rodríguez-Morales,"Rodríguez-Morales, A. J.; Bandeira, A. C.; Franco-Paredes, C.",The expanding spectrum of modes of transmission of Zika virus: a global concern,Ann Clin Microbiol Antimicrob,15,1,13,2016,2010-present,March 5, 2016,26939897,10.1186/s12941-016-0128-2,1200,English,http://www.ncbi.nlm.nih.gov/pubmed/26939897,"Public Health and Infection Research Group, Faculty of Health Sciences, Universidad Tecnologica de Pereira, Pereira, Risaralda, Colombia. ajrodriguezmmd@gmail.com.; Organizacion Latinoamericana para el Fomento de la Investigacion en Salud (OLFIS), Bucaramanga, Santander, Colombia. ajrodriguezmmd@gmail.com.; Hospital Alianca and Faculdade de Tecnologia e Ciencias Medical School, Salvador, Brazil. antoniobandeira@gmail.com.; Phoebe Putney Memorial Hospital, Albany, GA, USA. cparedes@ppmh.org.; Hospital Infantil de Mexico, Federico Gomez, Mexico, DF, Mexico. cparedes@ppmh.org.",,,,,,,Pubmed,March 31, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,413,,
414,"Hills, MMWR Morb Mortal Wkly Rep, 2016",Hills,"Hills, S. L., Russell, K., Hennessey, M., Williams, C., Oster, A. M., Fischer, M., Mead, P.","Transmission of Zika Virus Through Sexual Contact with Travelers to Areas of Ongoing Transmission - Continental United States, 2016",MMWR Morb Mortal Wkly Rep,65,8,215-6,2016,2010-present,March 5, 2016,26937739,10.15585/mmwr.mm6508e2,1205,English,,,,,,,,"Zika virus is a flavivirus closely related to dengue, West Nile, and yellow fever viruses. Although spread is primarily by Aedes species mosquitoes, two instances of sexual transmission of Zika virus have been reported (1,2), and replicative virus has been isolated from semen of one man with hematospermia (3). On February 5, 2016, CDC published recommendations for preventing sexual transmission of Zika virus (4). Updated prevention guidelines were published on February 23.* During February 6-22, 2016, CDC received reports of 14 instances of suspected sexual transmission of Zika virus. Among these, two laboratory-confirmed cases and four probable cases of Zika virus disease have been identified among women whose only known risk factor was sexual contact with a symptomatic male partner with recent travel to an area with ongoing Zika virus transmission. Two instances have been excluded based on additional information, and six others are still under investigation. State, territorial, and local public health departments, clinicians, and the public should be aware of current recommendations for preventing sexual transmission of Zika virus, particularly to pregnant women (4). Men who reside in or have traveled to an area of ongoing Zika virus transmission and have a pregnant partner should abstain from sexual activity or consistently and correctly use condoms during sex with their pregnant partner for the duration of the pregnancy (4).",Pubmed,March 31, 2016,Yes,,No,"Zika, not relevant to causality framework",Scientific (journal) article,No,Original research,No,Yes,414,Clinical/epidemiological research,Case series
415,"Chan, J Infect, 2016",Chan,"Chan, J. F., Choi, G. K., Yip, C. C., Cheng, V. C., Yuen, K. Y.",Zika fever and congenital Zika syndrome: An unexpected emerging arboviral disease,J Infect,,,,2016,2010-present,March 5, 2016,26940504,10.1016/j.jinf.2016.02.011,1198,English,,"State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong Special Administrative Region, China; Carol Yu Centre for Infection, The University of Hong Kong, Hong Kong Special Administrative Region, China; Research Centre of Infection and Immunology, The University of Hong Kong, Hong Kong Special Administrative Region, China; Department of Microbiology, The University of Hong Kong, Hong Kong Special Administrative Region, China., Department of Microbiology, The University of Hong Kong, Hong Kong Special Administrative Region, China., State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong Special Administrative Region, China; Carol Yu Centre for Infection, The University of Hong Kong, Hong Kong Special Administrative Region, China; Research Centre of Infection and Immunology, The University of Hong Kong, Hong Kong Special Administrative Region, China; Department of Microbiology, The University of Hong Kong, Hong Kong Special Administrative Region, China. Electronic address: kyyuen@hku.hk.",,,,,"Aedes, Arbovirus, Flavivirus, Microcephaly, Mosquito, Virus, Zika","Unlike its mosquito-borne relatives, such as dengue, West Nile, and Japanese encephalitis viruses, which can cause severe human diseases, Zika virus (ZIKV) has emerged from obscurity by its association with a suspected 'congenital Zika syndrome', while causing asymptomatic or mild exanthematous febrile infections which are dengue- or rubella-like in infected individuals. Despite having been discovered in Uganda for almost 60 years, <20 human cases were reported before 2007. The massive epidemics in the Pacific islands associated with the ZIKV Asian lineage in 2007 and 2013 were followed by explosive outbreaks in Latin America in 2015. Although increased mosquito breeding associated with the El Nino effect superimposed on global warming is suspected, genetic changes in its RNA virus genome may have led to better adaptation to mosquitoes, other animal reservoirs, and human. We reviewed the epidemiology, clinical manifestation, virology, pathogenesis, laboratory diagnosis, management, and prevention of this emerging infection. Laboratory diagnosis can be confounded by cross-reactivity with other circulating flaviviruses. Besides mosquito bite and transplacental transmission, the risk of other potential routes of transmission by transfusion, transplantation, sexual activity, breastfeeding, respiratory droplet, and animal bite is discussed. Epidemic control requires adequate clearance of mosquito breeding grounds, personal protection against mosquito bite, and hopefully a safe and effective vaccine.",Pubmed,March 31, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Yes,Review,No,Yes,415,Clinical/epidemiological research,Epidemiological/clinical review
416,"Marrs, Am J Perinatol, 2016",Marrs,"Marrs, C., Olson, G., Saade, G., Hankins, G., Wen, T., Patel, J., Weaver, S.",Zika Virus and Pregnancy: A Review of the Literature and Clinical Considerations,Am J Perinatol,,,,2016,2010-present,March 5, 2016,26939047,10.1055/s-0036-1580089,1202,English,,"Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, The University of Texas Medical Branch, Galveston, Texas., Division of Pediatric Infectious Diseases, Department of Pediatrics, The University of Texas Medical Branch, Galveston, Texas., Departments of Pathology and Microbiology and Immunology, The University of Texas Medical Branch, Galveston, Texas.",,,,,,"The latest Zika virus (ZIKV) outbreak has reached epidemic proportions as it spreads throughout South and Central America. In November 2015, the Brazilian Ministry of Health reported a 20-fold increase in the number of cases of neonatal microcephaly, which corresponds geographically and temporally to the ZIKV outbreak. Case reports have provided some evidence of a causal link between maternal ZIKV infection, fetal microcephaly, and intracranial calcifications. The sparse data regarding ZIKV in pregnancy come solely from case reports and personal communications, and recommendations for management of ZIKV exposure during pregnancy are rapidly evolving. Our objective is to review and synthesize the current literature regarding ZIKV as it pertains to pregnancy and provide some assistance to clinicians who may have to manage a pregnant patient with potential exposure to ZIKV. We will also explore certain aspects of related viruses in pregnancy in hopes to shed light on this little-known topic.",Pubmed,March 31, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Yes,Review,No,Yes,416,Clinical/epidemiological research,Epidemiological/clinical review
417,"Stratton, Prehosp Disaster Med, 2016",Stratton,"Stratton, S. J.",Zika Virus Association with Microcephaly: The Power for Population Statistics to Identify Public Health Emergencies,Prehosp Disaster Med,31,2,119-20,2016,2010-present,March 5, 2016,26940218,10.1017/s1049023x16000170,1199,English,,,,,,,,,Pubmed,March 31, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,417,,
418,"Meaney-Delman, MMWR Morb Mortal Wkly Rep, 2016",Meaney-Delman,"Meaney-Delman, D., Hills, S. L., Williams, C., Galang, R. R., Iyengar, P., Hennenfent, A. K., Rabe, I. B., Panella, A., Oduyebo, T., Honein, M. A., Zaki, S., Lindsey, N., Lehman, J. A., Kwit, N., Bertolli, J., Ellington, S., Igbinosa, I., Minta, A. A., Petersen, E. E., Mead, P., Rasmussen, S. A., Jamieson, D. J.",Zika Virus Infection Among U.S. Pregnant Travelers - August 2015-February 2016,MMWR Morb Mortal Wkly Rep,65,8,211-4,2016,2010-present,March 5, 2016,26938703,10.15585/mmwr.mm6508e1,1204,English,http://www.cdc.gov/mmwr/volumes/65/wr/pdfs/mm6508e1.pdf,ZikaMCH@cdc.gov,United States,Americas,United States,Not reported/unknown,,,Pubmed,March 31, 2016,Yes,,Yes,,Scientific (journal) article,No,Original research,No,Yes,418,Clinical/epidemiological research,Case series
419,"Brasil, N Engl J Med, 2016",Brasil,"Brasil, P., Pereira, J. P., Jr., Raja Gabaglia, C., Damasceno, L., Wakimoto, M., Ribeiro Nogueira, R. M., Carvalho de Sequeira, P., Machado Siqueira, A., Abreu de Carvalho, L. M., Cotrim da Cunha, D., Calvet, G. A., Neves, E. S., Moreira, M. E., Rodrigues Baiao, A. E., Nassar de Carvalho, P. R., Janzen, C., Valderramos, S. G., Cherry, J. D., Bispo de Filippis, A. M., Nielsen-Saines, K.",Zika Virus Infection in Pregnant Women in Rio de Janeiro - Preliminary Report,N Engl J Med,,,,2016,2010-present,March 5, 2016,26943629,10.1056/NEJMoa1602412,1194,English,http://www.nejm.org/doi/pdf/10.1056/NEJMoa1602412,"Division of Pediatric Infec- tious Diseases, David Geffen School of Medicine at UCLA, MDCC 22-442, 10833 LeConte Ave., Los Angeles, CA 90095,  knielsen@mednet.ucla.edu.",Brazil,Americas,United States,No funding received,,"Background Zika virus (ZIKV) has been linked to neonatal microcephaly. To characterize the spectrum of ZIKV disease in pregnancy, we followed patients in Rio de Janeiro to describe clinical manifestations in mothers and repercussions of acute ZIKV infection in fetuses. Methods We enrolled pregnant women in whom a rash had developed within the previous 5 days and tested blood and urine specimens for ZIKV by reverse-transcriptase-polymerase-chain-reaction assays. We followed the women prospectively and collected clinical and ultrasonographic data. Results A total of 88 women were enrolled from September 2015 through February 2016; of these 88 women, 72 (82%) tested positive for ZIKV in blood, urine, or both. The timing of acute ZIKV infection ranged from 5 to 38 weeks of gestation. Predominant clinical features included pruritic descending macular or maculopapular rash, arthralgias, conjunctival injection, and headache; 28% had fever (short-term and low-grade). Women who were positive for ZIKV were more likely than those who were negative for the virus to have maculopapular rash (44% vs. 12%, P=0.02), conjunctival involvement (58% vs. 13%, P=0.002), and lymphadenopathy (40% vs. 7%, P=0.02). Fetal ultrasonography was performed in 42 ZIKV-positive women (58%) and in all ZIKV-negative women. Fetal abnormalities were detected by Doppler ultrasonography in 12 of the 42 ZIKV-positive women (29%) and in none of the 16 ZIKV-negative women. Adverse findings included fetal deaths at 36 and 38 weeks of gestation (2 fetuses), in utero growth restriction with or without microcephaly (5 fetuses), ventricular calcifications or other central nervous system (CNS) lesions (7 fetuses), and abnormal amniotic fluid volume or cerebral or umbilical artery flow (7 fetuses). To date, 8 of the 42 women in whom fetal ultrasonography was performed have delivered their babies, and the ultrasonographic findings have been confirmed. Conclusions Despite mild clinical symptoms, ZIKV infection during pregnancy appears to be associated with grave outcomes, including fetal death, placental insufficiency, fetal growth restriction, and CNS injury.",Pubmed,March 31, 2016,Yes,,Yes,,Scientific (journal) article,Yes,Original research,No,Yes,419,Clinical/epidemiological research,Cohort study
420,"Gulland, BMJ, 2016",Gulland,"Gulland, A.","Zika virus may be linked to several birth defects, expert warns",BMJ,352,,i1322,2016,2010-present,March 5, 2016,26940642,10.1136/bmj.i1322,1197,English,,London.,,,,,,,Pubmed,March 31, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",News item or lay press,,,No,Yes,420,,
421,"Malone, PLoS Negl Trop Dis, 2016",Malone,"Malone, R. W., Homan, J., Callahan, M. V., Glasspool-Malone, J., Damodaran, L., Schneider Ade, B., Zimler, R., Talton, J., Cobb, R. R., Ruzic, I., Smith-Gagen, J., Janies, D., Wilson, J.",Zika Virus: Medical Countermeasure Development Challenges,PLoS Negl Trop Dis,10,3,e0004530,2016,2010-present,March 5, 2016,26934531,10.1371/journal.pntd.0004530,1208,English,,"RW Malone MD LLC, Scottsville, Virginia, United States of America., Class of 2016, Harvard Medical School Global Clinical Scholars Research Training Program, Boston, Massachusetts, United States of America., ioGenetics, Madison, Wisconsin, United States of America., Department of Medicine, Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, United States of America., Department of Bioinformatics and Genomics, University of North Carolina at Charlotte, Charlotte, North Carolina, United States of America., University of Florida, Department of Entomology and Nematology, Florida Medical Entomology Laboratory, Vero Beach, Florida, United States of America., Nanotherapeutics, NANO-ADM Advanced Development and Manufacturing Center, Alachua, Florida, United States of America., Analytical Outcomes, Washington Crossing, Pennsylvania, United States of America., School of Community Health Sciences, University of Nevada, Reno, Nevada, United States of America., Nevada Center for Infectious Disease Forecasting, University of Nevada, Reno, Nevada, United States of America.",,,,,,"INTRODUCTION: Reports of high rates of primary microcephaly and Guillain-Barre syndrome associated with Zika virus infection in French Polynesia and Brazil have raised concerns that the virus circulating in these regions is a rapidly developing neuropathic, teratogenic, emerging infectious public health threat. There are no licensed medical countermeasures (vaccines, therapies or preventive drugs) available for Zika virus infection and disease. The Pan American Health Organization (PAHO) predicts that Zika virus will continue to spread and eventually reach all countries and territories in the Americas with endemic Aedes mosquitoes. This paper reviews the status of the Zika virus outbreak, including medical countermeasure options, with a focus on how the epidemiology, insect vectors, neuropathology, virology and immunology inform options and strategies available for medical countermeasure development and deployment. METHODS: Multiple information sources were employed to support the review. These included publically available literature, patents, official communications, English and Lusophone lay press. Online surveys were distributed to physicians in the US, Mexico and Argentina and responses analyzed. Computational epitope analysis as well as infectious disease outbreak modeling and forecasting were implemented. Field observations in Brazil were compiled and interviews conducted with public health officials.",Pubmed,March 31, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Yes,Review,No,Yes,421,Clinical/epidemiological research,Epidemiological/clinical review
422,"Dupont-Rouzeyrol, Lancet, 2016",Dupont-Rouzeyrol,"Dupont-Rouzeyrol, M.; Biron, A.; O'Connor, O.; Huguon, E.; Descloux, E.",Infectious Zika viral particles in breastmilk,Lancet,387,10023,1051,2016,2010-present,March 6, 2016,26944028,10.1016/S0140-6736(16)00624-3,1191,English,http://www.ncbi.nlm.nih.gov/pubmed/26944028,"Institut Pasteur de Nouvelle-Caledonie, Reseau International des Instituts Pasteur, Noumea Cedex, New Caledonia. Electronic address: mdupont@pasteur.nc.; Institut Pasteur de Nouvelle-Caledonie, Reseau International des Instituts Pasteur, Noumea Cedex, New Caledonia.; Centre Hospitalier Territorial, Noumea Cedex, New Caledonia.",,,,,,,Pubmed,March 31, 2016,Yes,,No,"Zika, not relevant to causality framework",Scientific (journal) article,Yes,Original research,No,Yes,422,Clinical/epidemiological research,Case report
423,"Jouannic, Lancet, 2016",Jouannic,"Jouannic, J. M., Friszer, S., Leparc-Goffart, I., Garel, C., Eyrolle-Guignot, D.",Zika virus infection in French Polynesia,Lancet,387,10023,1051-2,2016,2010-present,March 6, 2016,26944027,10.1016/s0140-6736(16)00625-5,1192,English,,"Service de Medecine Foetale, Hopital Armand Trousseau, Assistance Publique-Hopitaux de Paris, Universite Pierre et Marie Curie, Paris, France. Electronic address: jean-marie.jouannic@aphp.fr., Service de Medecine Foetale, Hopital Armand Trousseau, Assistance Publique-Hopitaux de Paris, Universite Pierre et Marie Curie, Paris, France., Centre National de Reference des arbovirus, Institut de Recherche Biomedicale des Armees, Service de Biologie, Hopital d'Instruction des Armees Laveran, Marseille, France., Service de Radiologie Pediatrique, Hopital Armand Trousseau, Assistance Publique-Hopitaux de Paris, Universite Pierre et Marie Curie, Paris, France., Service de Gynecologie-Obstetrique, Centre Hospitalier Territorial, Mamao, Papeete, French Polynesia.",France,Europe,French Polynesia,Not reported/unknown,Zika Virus Infection; Microcephaly,"French Polynesia was affected by an epidemic of Zika between September, 2013, and March, 2014. In 2014, 13 cases of fetal cerebral anomaly were diagnosed, compared with four in 2013 and three in 2012. Retrospective testing of stored amniotic fluid samples for ZIKV because of possible fetal cerebral damage secondary to maternity Zika infection; diagnosis of cerebral anomaly with MRI or ultrasound.",Pubmed,March 31, 2016,Yes,,Yes,,Scientific (journal) article,Unknown/unclear,Original research,Yes,No,542,Clinical/epidemiological research,Case series
424,"Li, Sci China Life Sci, 2016",Li,"Li, X. F., Han, J. F., Shi, P. Y., Qin, C. F.",Zika virus: a new threat from mosquitoes,Sci China Life Sci,,,,2016,2010-present,March 6, 2016,26944581,10.1007/s11427-016-5020-y,1190,English,,"Department of Virology, Beijing Institute of Microbiology and Epidemiology, Beijing, 100071, China., State Key Laboratory of Pathogen and Biosecurity, Beijing, 100071, China., Department of Biochemistry and Molecular Biology, Department of Phamarcology & Toxicology, Sealy Center for Structural Biology & Molecular Biophysics, University of Texas Medical Branch, Galveston, Texas, 77555, USA. qincf@bmi.ac.cn., Department of Virology, Beijing Institute of Microbiology and Epidemiology, Beijing, 100071, China. peshi@utmb.gov., State Key Laboratory of Pathogen and Biosecurity, Beijing, 100071, China. peshi@utmb.gov.",,,,,,,Pubmed,March 31, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,424,,
425,"Reyna-Villasmil, Med Clin (Barc), 2016",Reyna-Villasmil,"Reyna-Villasmil, E.; Lopez-Sanchez, G.; Santos-Bolivar, J.",[Guillain-Barre syndrome due to Zika virus during pregnancy],Med Clin (Barc),146,7,331-2,2016,2010-present,March 8, 2016,26947168,10.1016/j.medcli.2016.02.002,1185,Spanish,http://www.ncbi.nlm.nih.gov/pubmed/26947168,"Servicio de Ginecologia y Obstetricia, Hospital Central Dr. Urquinaona, Maracaibo, Estado Zulia, Venezuela. Electronic address: sippenbauch@gmail.com.; Servicio de Medicina Interna, Hospital Central Dr. Urquinaona, Maracaibo, Estado Zulia, Venezuela.; Servicio de Ginecologia y Obstetricia, Hospital Central Dr. Urquinaona, Maracaibo, Estado Zulia, Venezuela.",Venezuela,Americas,Venezuela,Not reported/unknown,,,Pubmed,March 31, 2016,Yes,,Yes,,Scientific (journal) article,Yes,Original research,Yes,Yes,425,Clinical/epidemiological research,Case report
426,"Roure, Med Clin (Barc), 2016",Roure,"Roure, S.; de Ory, F.; Matas, L.",[Infection imported virus Zika in an area settled by Aedes albopictus],Med Clin (Barc),146,7,332-3,2016,2010-present,March 8, 2016,26947167,10.1016/j.medcli.2016.02.003,1186,Spanish,http://www.ncbi.nlm.nih.gov/pubmed/26947167,"Unidad de Salud Internacional PROSICS Metropolitana Norte, Santa Coloma de Gramenet, Espana; Unidad de Enfermedades Infecciosas, Servicio de Medicina Interna, Hospital Universitari Germans Trias i Pujol, Badalona, Espana. Electronic address: sroura.mn.ics@gencat.cat.; Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Madrid, Espana.; Servicio de Microbiologia Clinica, Hospital Universitari Germans Trias i Pujol, Badalona, Espana.",,,,,,,Pubmed,March 31, 2016,Yes,,No,"Zika, not relevant to causality framework",Scientific (journal) article,Unknown/unclear,Original research,No,Yes,426,Clinical/epidemiological research,Case report
427,"Trilla, Med Clin (Barc), 2016",Trilla,"Trilla, A., Vilella, A.",[The Zika virus out of America],Med Clin (Barc),146,7,308-10,2016,2010-present,March 8, 2016,26947169,10.1016/j.medcli.2016.02.004,1184,Spanish,,"Servicio de Medicina Preventiva y Epidemiologia, Hospital Clinic; Departamento de Salud Publica, Universidad de Barcelona; Instituto de Salud Global de Barcelona (ISGlobal), Barcelona, Espana. Electronic address: atrilla@clinic.cat., Servicio de Medicina Preventiva y Epidemiologia, Hospital Clinic; Departamento de Salud Publica, Universidad de Barcelona; Instituto de Salud Global de Barcelona (ISGlobal), Barcelona, Espana.",,,,,,,Pubmed,March 31, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,427,,
428,"Mecharles, Lancet, 2016",Mecharles,"Mecharles, S.; Herrmann, C.; Poullain, P.; Tran, T. H.; Deschamps, N.; Mathon, G.; Landais, A.; Breurec, S.; Lannuzel, A.",Acute myelitis due to Zika virus infection,Lancet,387,10026,1481,2016,2010-present,March 8, 2016,26946926,10.1016/S0140-6736(16)00644-9,1187,English,http://www.ncbi.nlm.nih.gov/pubmed/26946926,"Service de Neurologie, Centre Hospitalier Universitaire de Pointe-a-Pitre, Guadeloupe, French West Indies.; Laboratoire de Microbiologie Clinique et Environnementale, Centre Hospitalier Universitaire de Pointe-a-Pitre, Guadeloupe, French West Indies.; Service de Radiologie, Centre Hospitalier Universitaire de Pointe-a-Pitre, Guadeloupe, French West Indies.; Laboratoire de Microbiologie Clinique et Environnementale, Centre Hospitalier Universitaire de Pointe-a-Pitre, Guadeloupe, French West Indies; Faculte de Medecine de l'Universite des Antilles, Faculte de Medecine, French West Indies; Institut Pasteur de Guadeloupe, Unite Sante et Environnement, Pointe-a-Pitre, French West Indies.; Service de Neurologie, Centre Hospitalier Universitaire de Pointe-a-Pitre, Guadeloupe, French West Indies; Faculte de Medecine de l'Universite des Antilles, Faculte de Medecine, French West Indies; Institut National de la Sante et de la Recherche Medicale, U 1127, CNRS, Unite Mixte de Recherche (UMR) 7225, Sorbonne Universites, Institut du Cerveau et de la Moelle epiniere, ICM, Paris, France. Electronic address: annie.lannuzel@chu-guadeloupe.fr.",Guadeloupe,Americas,Guadeloupe,Not reported/unknown,Acute Myelitis; Zika Virus infection,"In January, 2016, a 15-year-old girl, Guadeloupe, with left hemiparesis. 7 days previously she had presented with left arm pain, frontal headaches, and conjunctival hyperaemia, but no fever, signs of meningeal irritation, or sensory or motor deficits. The day of admission, she developed acute lower back pain, paraesthesia on the left side of her body, and weakness in her left arm. On admission she had slight left-sided weakness and proximal pain of the left arm and leg, exacerbated on movement, but no fever or signs of meningism.",Pubmed,March 31, 2016,Yes,,No,"Zika, indirect evidence or other topic",Scientific (journal) article,Yes,Original research,No,Yes,428,Clinical/epidemiological research,Case report
429,"Alvarado-Socarras, Ultrasound Obstet Gynecol, 2016",Alvarado-Socarras,"Alvarado-Socarras, J. L.; Rodriguez-Morales, A. J.",Etiological agents of microcephaly: implications for diagnosis during the current Zika virus epidemic,Ultrasound Obstet Gynecol,,,,2016,2010-present,March 8, 2016,26947268,10.1002/uog.15885,1183,English,http://www.ncbi.nlm.nih.gov/pubmed/26947268,"Neonatal Unit, Department of Pediatrics, Fundacion Cardiovascular de Colombia, Floridablanca, Santander, Colombia.; Organizacion Latinoamericana para el Fomento, de la Investigacion en Salud (OLFIS), Bucaramanga, Santander, Colombia.; Public Health and Infection Research Group, Faculty of Health Sciences, Universidad Tecnologica de Pereira, Pereira, Risaralda, Colombia.",,,,,,,Pubmed,March 31, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,429,,
430,"Cao-Lormeau, Lancet, 2016",Cao-Lormeau,"Cao-Lormeau, V. M.; Blake, A.; Mons, S.; Lastere, S.; Roche, C.; Vanhomwegen, J.; Dub, T.; Baudouin, L.; Teissier, A.; Larre, P.; Vial, A. L.; Decam, C.; Choumet, V.; Halstead, S. K.; Willison, H. J.; Musset, L.; Manuguerra, J. C.; Despres, P.; Fournier, E.; Mallet, H. P.; Musso, D.; Fontanet, A.; Neil, J.; Ghawche, F.",Guillain-Barre Syndrome outbreak associated with Zika virus infection in French Polynesia: a case-control study,Lancet,,,,2016,2010-present,March 8, 2016,26948433,10.1016/S0140-6736(16)00562-6,1180,English,http://www.ncbi.nlm.nih.gov/pubmed/26948433,"Unit of Emerging Infectious Diseases, Institut Louis Malarde, Papeete, Tahiti, French Polynesia.; Institut Pasteur, Emerging Diseases Epidemiology Unit, Paris, France.; Service de Reanimation Polyvalente, Centre Hospitalier de Polynesie Francaise, Tahiti, French Polynesia.; Clinical Laboratory, Centre Hospitalier de Polynesie Francaise, Tahiti, French Polynesia.; Institut Pasteur, Laboratory for Urgent Responses to Biological Threats, Paris, France; Unit Environment and Infectious Risks, Institut Pasteur, Paris, France.; Service de neurologie, Centre Hospitalier de Polynesie Francaise, Papeete, Tahiti, Polynesie Francaise.; Direction de la Sante, Bureau de Veille Sanitaire, Papeete, French Polynesia.; Service de sante des forces armees, Papeete, French Polynesia.; Unit Environment and Infectious Risks, Institut Pasteur, Paris, France.; Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.; Department of Immunology, Laboratory of Immunochemistry & Autoimmunity, Pitie-Salpetriere Hospital (AP-HP), Paris, France.; University of Reunion Island, La Reunion, France.; Departement de Neurophysiologie, Pitie-Salpetriere Hospital (AP-HP), Paris, France.; Institut Pasteur, Emerging Diseases Epidemiology Unit, Paris, France; Conservatoire National des Arts et Metiers, Paris, France; Institut Pasteur, Centre for Global Health Research and Education, Paris, France. Electronic address: fontanet@pasteur.fr.",French Polynesia,Pacific,French Polynesia,Public/Government,,"BACKGROUND: Between October, 2013, and April, 2014, French Polynesia experienced the largest Zika virus outbreak ever described at that time. During the same period, an increase in Guillain-Barre syndrome was reported, suggesting a possible association between Zika virus and Guillain-Barre syndrome. We aimed to assess the role of Zika virus and dengue virus infection in developing Guillain-Barre syndrome. METHODS: In this case-control study, cases were patients with Guillain-Barre syndrome diagnosed at the Centre Hospitalier de Polynesie Francaise (Papeete, Tahiti, French Polynesia) during the outbreak period. Controls were age-matched, sex-matched, and residence-matched patients who presented at the hospital with a non-febrile illness (control group 1; n=98) and age-matched patients with acute Zika virus disease and no neurological symptoms (control group 2; n=70). Virological investigations included RT-PCR for Zika virus, and both microsphere immunofluorescent and seroneutralisation assays for Zika virus and dengue virus. Anti-glycolipid reactivity was studied in patients with Guillain-Barre syndrome using both ELISA and combinatorial microarrays. FINDINGS: 42 patients were diagnosed with Guillain-Barre syndrome during the study period. 41 (98%) patients with Guillain-Barre syndrome had anti-Zika virus IgM or IgG, and all (100%) had neutralising antibodies against Zika virus compared with 54 (56%) of 98 in control group 1 (p<0.0001). 39 (93%) patients with Guillain-Barre syndrome had Zika virus IgM and 37 (88%) had experienced a transient illness in a median of 6 days (IQR 4-10) before the onset of neurological symptoms, suggesting recent Zika virus infection. Patients with Guillain-Barre syndrome had electrophysiological findings compatible with acute motor axonal neuropathy (AMAN) type, and had rapid evolution of disease (median duration of the installation and plateau phases was 6 [IQR 4-9] and 4 days [3-10], respectively). 12 (29%) patients required respiratory assistance. No patients died. Anti-glycolipid antibody activity was found in 13 (31%) patients, and notably against GA1 in eight (19%) patients, by ELISA and 19 (46%) of 41 by glycoarray at admission. The typical AMAN-associated anti-ganglioside antibodies were rarely present. Past dengue virus history did not differ significantly between patients with Guillain-Barre syndrome and those in the two control groups (95%, 89%, and 83%, respectively). INTERPRETATION: This is the first study providing evidence for Zika virus infection causing Guillain-Barre syndrome. Because Zika virus is spreading rapidly across the Americas, at risk countries need to prepare for adequate intensive care beds capacity to manage patients with Guillain-Barre syndrome. FUNDING: Labex Integrative Biology of Emerging Infectious Diseases, EU 7th framework program PREDEMICS. and Wellcome Trust.",Pubmed,March 31, 2016,Yes,,Yes,,Scientific (journal) article,Yes,Original research,Yes,Yes,430,Clinical/epidemiological research,Case-control study
431,"Attaway, Acta Trop, 2016",Attaway,"Attaway, D. F., Jacobsen, K. H., Falconer, A., Manca, G., Waters, N. M.",Risk analysis for dengue suitability in Africa using the ArcGIS Predictive Analysis Tools (PA Tools),Acta Trop,,,,2016,2010-present,March 8, 2016,26945482,10.1016/j.actatropica.2016.02.018,1189,English,,"Department of Geography and GeoInformation Science, George Mason University, 4400 University Drive, MS 6C3, Fairfax, VA 22030-4444, USA; Esri, 8615 Westwood Center Drive, Vienna, VA 22182, USA. Electronic address: dattaway@esri.com., Department of Global and Community Health, George Mason University, 4400 University Drive, MS 5B7, Fairfax, VA 22030-4444, USA., Department of Geography and GeoInformation Science, George Mason University, 4400 University Drive, MS 6C3, Fairfax, VA 22030-4444, USA., Laboratory for Geoinformatics and Earth Observations, Department of Geography and Institute for Cyberscience, The Pennsylvania State University, University Park, PA, USA., Department of Geography and GeoInformation Science, George Mason University, 4400 University Drive, MS 6C3, Fairfax, VA 22030-4444, USA; Institute of Public Health, Faculty of Medicine, University of Calgary, 3280Hospital Drive NW, Calgary, AB T2 N 4Z6, Canada.",,,,,"Africa, Background, dengue, developing countries, geographic information systems, medical geography, risk mapping","BACKGROUND: Risk maps identifying suitable locations for infection transmission are important for public health planning. Data on dengue infection rates are not readily available in most places where the disease is known to occur. METHODS: A newly available add-in to Esri's ArcGIS software package, the ArcGIS Predictive Analysis Toolset (PA Tools), was used to identify locations within Africa with environmental characteristics likely to be suitable for transmission of dengue virus. RESULTS: A more accurate, robust, and localized (1km x 1km) dengue risk map for Africa was created based on bioclimatic layers, elevation data, high-resolution population data, and other environmental factors that a search of the peer-reviewed literature showed to be associated with dengue risk. Variables related to temperature, precipitation, elevation, and population density were identified as good predictors of dengue suitability. Areas of high dengue suitability occur primarily within West Africa and parts of Central Africa and East Africa, but even in these regions the suitability is not homogenous. CONCLUSION: This risk mapping technique for an infection transmitted by Aedes mosquitoes draws on entomological, epidemiological, and geographic data. The method could be applied to other infectious diseases (such as Zika) in order to provide new insights for public health officials and others making decisions about where to increase disease surveillance activities and implement infection prevention and control efforts. The ability to map threats to human and animal health is important for tracking vectorborne and other emerging infectious diseases and modeling the likely impacts of climate change.",Pubmed,March 31, 2016,No,Unrelated to Zika virus,,,Scientific (journal) article,Yes,Other,No,Yes,431,,
432,"[No authors listed], Emerg Nurse, 2016",[No authors listed],[No authors listed],Science committee calls on government to build Zika virus evidence base,Emerg Nurse,23,10,6,2016,2010-present,March 8, 2016,26948207,10.7748/en.23.10.6.s3,1182,English,http://www.ncbi.nlm.nih.gov/pubmed/26948207,,,,,,,SCIENCE AND Technology Committee chair Nicola Blackwood MP has written to health secretary Jeremy Hunt to urge the government to take 'urgent steps' to develop a robust evidence base to tackle the Zika virus.,Pubmed,March 31, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",News item or lay press,,,No,Yes,432,,
433,"Smith, Lancet, 2016",Smith,"Smith, D. W., Mackenzie, J.",Zika virus and Guillain-Barre syndrome: another viral cause to add to the list,Lancet,,,,2016,2010-present,March 8, 2016,26948432,10.1016/s0140-6736(16)00564-x,1181,English,,"School of Pathology and Laboratory Medicine, University of Western Australia, Nedlands, WA 6009, Australia. Electronic address: david.smith@health.wa.gov.au., Faculty of Health Science, Curtin University, Bentley, WA, Australia.",,,,,,,Pubmed,March 31, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,433,,
434,"Rowland, J Assist Reprod Genet, 2016",Rowland,"Rowland, A., Washington, C. I., Sheffield, J. S., Pardo-Villamizar, C. A., Segars, J. H.",Zika virus infection in semen: a call to action and research,J Assist Reprod Genet,,,,2016,2010-present,March 8, 2016,26945753,10.1007/s10815-016-0684-6,1188,English,,"The Johns Hopkins University School of Medicine, 733 North Broadway, Baltimore, MD, 21205, USA., Division of Reproductive Sciences and Women's Health Research, Department of Gynecology and Obstetrics, The Johns Hopkins University School of Medicine, 720 Rutland Avenue, Room 624 Ross Building, Baltimore, MD, 21205, USA., Division of Maternal-Fetal Medicine, Department of Gynecology and Obstetrics, The Johns Hopkins University School of Medicine, 600 North Wolfe Street, Phipps Building, Room 203, Baltimore, MD, 21287, USA., Department of Neurology, The Johns Hopkins University School of Medicine, David H. Koch Cancer Research Building II, 1550 Orleans Street, Room 1M16, Baltimore, MD, 21287, USA., Division of Reproductive Sciences and Women's Health Research, Department of Gynecology and Obstetrics, The Johns Hopkins University School of Medicine, 720 Rutland Avenue, Room 624 Ross Building, Baltimore, MD, 21205, USA. jsegars2@jhmi.edu.",,,,,,,Pubmed,March 31, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,434,,
435,"Mansuy, Lancet Infect Dis, 2016",Mansuy,"Mansuy, J. M., Dutertre, M., Mengelle, C., Fourcade, C., Marchou, B., Delobel, P., Izopet, J., Martin-Blondel, G.","Zika virus: high infectious viral load in semen, a new sexually transmitted pathogen?",Lancet Infect Dis,,,,2016,2010-present,March 8, 2016,26949027,10.1016/s1473-3099(16)00138-9,1179,English,,"Laboratoire de Virologie, Institut Federatif de Biologie, Centre Hospitalier et Universitaire, Toulouse 31059, France. Electronic address: mansuy.jm@chu-toulouse.fr., Services des Maladies Infectieuses et Tropicales, Centre Hospitalier et Universitaire, Toulouse, France; INSERM U1043-CNRS UMR 5282, Centre de Physiopathologie Toulouse-Purpan, France., Laboratoire de Virologie, Institut Federatif de Biologie, Centre Hospitalier et Universitaire, Toulouse 31059, France., Services des Maladies Infectieuses et Tropicales, Centre Hospitalier et Universitaire, Toulouse, France., Laboratoire de Virologie, Institut Federatif de Biologie, Centre Hospitalier et Universitaire, Toulouse 31059, France; INSERM U1043-CNRS UMR 5282, Centre de Physiopathologie Toulouse-Purpan, France.",,,,,,"The recent, rapid spread of Zika virus in South America and increasing reports of cases of congenital abnormalities spatiotemporally associated with Zika virus infections led WHO to declare a Public Health Emergency of International Concern on Feb 1. WHO also recently described measures that pregnant women should take to avoid infection.",Pubmed,March 31, 2016,Yes,,No,"Zika, not relevant to causality framework",Scientific (journal) article,Yes,Original research,No,Yes,435,Clinical/epidemiological research,Case report
436,"Cabrera-Gaytan, Rev Med Inst Mex Seguro Soc, 2016",Cabrera-Gaytan,"Cabrera-Gaytan, D. A.; Galvan-Hernandez, S. A.",[Clinical features of Zika virus],Rev Med Inst Mex Seguro Soc,54,2,225-9,2016,2010-present,March 10, 2016,26960051,,1157,Spanish,http://www.ncbi.nlm.nih.gov/pubmed/26960051,"Coordinacion de Vigilancia Epidemiologica, Unidad de Atencion Primaria a la Salud, Direccion de Prestaciones Medicas, Instituto Mexicano del Seguro Social, Ciudad de Mexico, Mexico. david.cabrerag@imss.gob.mx; dcpreventiva@gmail.com.",,,,,Arbovirus infections; Arboviruses; Epidemiological surveillance; Exanthema,"BACKGROUND: Zika virus was introduced to the country and threatens to spread, so the health personnel must be able to identify the disease and face an operational definition given case; in this review the clinical manifestations of probable cases of Zika of the last five years were described. METHODS: A search was performed in Google Scholar and PubMed with 'Zika'. He settled for a database and obtained simple frequencies and calculated the limits for proportions with an alpha of 0.05 through test Wilson. RESULTS: 109 probable cases of fever came together by Zika, the clinical manifestations was heterogeneous, with predominant involvement to musculoskeletal, dermatological and systemic level. CONCLUSIONS: It is necessary to continue the documentation of the clinical manifestations of Zika virus, which will be achieved by strengthening epidemiological surveillance.; Publisher: Abstract available from the publisher.; spa",Pubmed,March 31, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Review,No,Yes,436,Clinical/epidemiological research,Epidemiological/clinical review
437,"Barrera-Cruz, Rev Med Inst Mex Seguro Soc, 2016",Barrera-Cruz,"Barrera-Cruz, A., Diaz-Ramos, R. D., Lopez-Morales, A. B., Grajales-Muniz, C., Viniegra-Osorio, A., Zaldivar-Cervera, J. A., Arriaga-Davila, J. J.","[Technical guidelines for the prevention, diagnosis and treatment of Zika virus infection]",Rev Med Inst Mex Seguro Soc,54,2,211-24,2016,2010-present,March 10, 2016,26960050,,1158,Spanish,,"Coordinacion Tecnica de Excelencia Clinica, Unidad de Atencion Medica, Direccion de Prestaciones Medicas, Instituto Mexicano del Seguro Social, Ciudad de Mexico, Mexico. antonio.barrera@imss.gob.mx.",,,,,"Arbovirus infections, Arboviruses, Communicable disease control, Epidemiology, Virus diseases","Infection Zika virus is an emerging disease in the Americas region, which is caused by Zika virus (ZIKV), an arbovirus of the flavivirus genus. The ZIKV is transmitted by the bite of Aedes mosquitoes, both in urban and jungle area. After the mosquito bite, the disease symptoms usually appear after an incubation period of three to twelve days. The infection may be asymptomatic or presented with fever and not purulent conjunctivitis, headache, myalgia, arthralgia, asthenia, maculopapular rash, edema in lower limbs and, less frequently, retro-orbital pain, anorexia, vomiting, diarrhea or pain abdominal. Symptoms last for 4-7 days and are self-limiting. Neurological and autoimmune complications are rare. Since 2014 it has been detected native circulation of Zika virus in the Americas. So far, there is no specific antiviral treatment or effective vaccine, so it s giving priority symptomatic and supportive treatment for the acute phase and make an early diagnosis of atypical and severe forms., Publisher: Abstract available from the publisher., spa",Pubmed,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Unknown/unclear,Original research,No,Yes,437,Clinical/epidemiological research,Guidelines
438,"Paixao, Am J Public Health, 2016",Paixao,"Paixao, E. S.; Barreto, F.; da Gloria Teixeira, M.; da Conceicao, N. Costa M.; Rodrigues, L. C.","History, Epidemiology, and Clinical Manifestations of Zika: A Systematic Review",Am J Public Health,106,4,606-12,2016,2010-present,March 10, 2016,26959260,10.2105/AJPH.2016.303112,1160,English,http://www.ncbi.nlm.nih.gov/pubmed/26959260,"Enny S. Paixao and Laura C. Rodrigues are with the London School of Hygiene and Tropical Medicine, London, England. Florisneide Barreto, Maria da Gloria Teixeira, and Maria da Conceicao N. Costa are with the Instituto de Saude Coletiva-Universidade Federal da Bahia, Salvador, Brazil.",,,,,,"OBJECTIVES: To describe salient epidemiological characteristics of Zika virus outbreaks across the world and to examine the clinical presentations, complications, and atypical manifestations related to their occurrence in recent history. METHODS: We conducted a systematic review of the literature by searching through MEDLINE, Embase, and Global Health Library, as well as the epidemiological bulletins and alerts from the World Health Organization, the Pan American Health Organization, and the European Centre for Disease Prevention and Control over the period 1954 to 2016. RESULTS: The search yielded 547 records. We retained 333 for further analysis, to which we added 11 epidemiological bulletins from various sources. Of these, we systematically reviewed 52 articles and reports, revealing some epidemiological features and patterns of spread of the Zika virus worldwide, as well as pathological outcomes suspected to be linked to Zika outbreaks. Neurologic disorders among zika patients were similar in Brazil and French Polynesia but a causal link is not established. Incidence of zika infection in pregnant women is not known. In Brazil, during the zika outbreak the incidence of microcephaly increased more than 20 times. Among 35 infants with microcephaly, born from women suspected to have Zika infection during pregnancy in northeast Brazil, 74% of the mothers reported rash during the first and second trimester. CONCLUSIONS: On February 1, 2016, The World Health Organization declared the ongoing Zika crisis an emergency and that, although not yet scientifically proven, the link between the virus and growing numbers of microcephaly cases was 'strongly suspected.' However, the causal relationship between zika and microcephaly is not universally accepted. Public Health Implications. The current situation with regard to Zika is not encouraging, because there is no vaccine, no treatment, and no good serological test, and vector control remains a challenge.",Pubmed,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Yes,Review,No,Yes,438,Clinical/epidemiological research,Epidemiological/clinical review
439,"Miranda-Filho, Am J Public Health, 2016",Miranda-Filho,"Miranda-Filho, B.; Martelli, C. M.; Ximenes, R. A.; Araujo, T. V.; Rocha, M. A.; Ramos, R. C.; Dhalia, R.; Franca, R. F.; Marques Junior, E. T.; Rodrigues, L. C.",Initial Description of the Presumed Congenital Zika Syndrome,Am J Public Health,106,4,598-600,2016,2010-present,March 10, 2016,26959258,10.2105/AJPH.2016.303115,1162,English,http://www.ncbi.nlm.nih.gov/pubmed/26959258,"Democrito de Barros Miranda-Filho, Ricardo Arraes de Alencar Ximenes, Maria Angela Wanderley Rocha, and Regina Coeli Ferreira Ramos are with the University of Pernambuco, Recife, Brazil. Celina Maria Turchi Martelli, Rafael Dhalia, Rafael Freitas de Oliveira Franca, and Ernesto T. A. Marques Junior are with The Research Center Aggeu Magalhaes (CPqAM)/Oswaldo Cruz Foundation (Fiocruz), Recife. Thalia Velho Barreto Araujo and Ricardo Arraes de Alencar Ximenes are with the Federal University of Pernambuco, Recife. Laura Cunha Rodrigues is with the London School of Hygiene and Tropical Medicine, London, UK.",United Kingdom,Europe,United Kingdom,Public/Government,Zika Virus Infection; congenital microcephaly; congenital infections,"OBJECTIVES: To provide an initial description of the congenital syndrome presumably associated with infection by Zika virus compared with other syndromes including congenital infections of established etiologies. METHODS: We provide an overview of a published case series of 35 cases, a clinical series of 104 cases, and published and unpublished reports of clinical and laboratory findings describing cases diagnosed since the beginning of the epidemic of microcephaly in Brazil. RESULTS: About 60% to 70% of mothers report rash during pregnancy; mainly in the first trimester. Principal features are microcephaly, facial disproportionality, cutis girata, hypertonia/spasticity, hyperreflexia, and irritability; abnormal neuroimages include calcifications, ventriculomegaly, and lissencephaly. Hearing and visual abnormalities may be present. CONCLUSIONS: Preliminary data suggest that severe congenital abnormalities are linked to Zika virus infection. Cases have severe abnormalities, and although sharing many characteristics with congenital abnormalities associated with other viral infections, abnormalities presumably linked to the Zika virus may have distinguishing characteristics. These severe neurologic abnormalities may result in marked mental retardation and motor disabilities for many surviving offspring. POLICY IMPLICATIONS: Affected nations need to prepare to provide complex and costly multidisciplinary care that children diagnosed with this new congenital syndrome will require.",Pubmed,March 31, 2016,Yes,,Yes,,Scientific (journal) article,Yes,Review,Yes,No,758,Clinical/epidemiological research,Case series
440,"Heymann, N Engl J Med, 2016",Heymann,"Heymann, D. L., Liu, J., Lillywhite, L.","Partnerships, Not Parachutists, for Zika Research",N Engl J Med,,,,2016,2010-present,March 10, 2016,26958936,10.1056/NEJMp1602278,1165,English,,"From the Centre on Global Health Security, Chatham House (D.L.H., L.L.); Public Health England (D.L.H.); and the London School of Hygiene and Tropical Medicine (D.L.H.) - all in London; and Medecins sans Frontieres, Geneva (J.L.).",,,,,,"When the director-general of the World Health Organization (WHO) declared that the recently reported clusters of microcephaly and other neurologic disorders represent a Public Health Emergency of International Concern (PHEIC), she called for increased research into their cause, including the question of whether the Zika virus is the source of the problem.1 The declaration provides an opportunity to step up the pace of research in order to find the answer to some important questions more quickly. It could not only facilitate the accumulation of knowledge about the relationship between the Zika virus and microcephaly, but also accelerate the study of . . .",Pubmed,March 31, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,440,,
441,"Bell, Am J Public Health, 2016",Bell,"Bell, B. P., Boyle, C. A., Petersen, L. R.",Preventing Zika Virus Infections in Pregnant Women: An Urgent Public Health Priority,Am J Public Health,106,4,589-90,2016,2010-present,March 10, 2016,26959253,10.2105/ajph.2016.303124,1163,English,,"Beth P. Bell is the Director of the National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention (CDC), Atlanta, GA, Coleen A. Boyle is the Director of the National Center on Birth Defects and Developmental Disabilities, CDC, Atlanta. Lyle R. Petersen is Director of the Division of Vector-Borne Diseases, CDC, Ft. Collins, CO.",,,,,,,Pubmed,March 31, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,441,,
442,"Adibi, Lancet, 2016",Adibi,"Adibi, J. J., Marques, E. T., Jr., Cartus, A., Beigi, R. H.",Teratogenic effects of the Zika virus and the role of the placenta,Lancet,,,,2016,2010-present,March 10, 2016,26952548,10.1016/s0140-6736(16)00650-4,1174,English,,"Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA; Department of Obstetrics and Gynecology and Reproductive Sciences, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address: adibij@pitt.edu., Center for Vaccine Research, University of Pittsburgh, Pittsburgh, PA, USA; The Research Center Aggeu Magalhaes (CPqAM)/Oswaldo Cruz Foundation (Fiocruz), Recife, Brazil., Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, University of Texas Health Sciences Center, Houston, TX, USA., Department of Obstetrics and Gynecology and Reproductive Sciences, University of Pittsburgh, Pittsburgh, PA, USA.",,,,,,"The mechanism by which the Zika virus can cause fetal microcephaly is not known. Reports indicate that Zika is able to evade the normal immunoprotective responses of the placenta. Microcephaly has genetic causes, some associated with maternal exposures including radiation, tobacco smoke, alcohol, and viruses. Two hypotheses regarding the role of the placenta are possible: one is that the placenta directly conveys the Zika virus to the early embryo or fetus. Alternatively, the placenta itself might be mounting a response to the exposure; this response might be contributing to or causing the brain defect. This distinction is crucial to the diagnosis of fetuses at risk and the design of therapeutic strategies to prevent Zika-induced teratogenesis.",Pubmed,March 31, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,442,,
443,"Teixeira, Am J Public Health, 2016",Teixeira,"Teixeira, M. G.; da Conceicao, N. Costa M.; de Oliveira, W. K.; Nunes, M. L.; Rodrigues, L. C.","The Epidemic of Zika Virus-Related Microcephaly in Brazil: Detection, Control, Etiology, and Future Scenarios",Am J Public Health,106,4,601-5,2016,2010-present,March 10, 2016,26959259,10.2105/AJPH.2016.303113,1161,English,http://www.ncbi.nlm.nih.gov/pubmed/26959259,"Maria G. Teixeira and Maria da Conceicao N. Costa are with Instituto de Saude Coletiva-Universidade Federal da Bahia, Salvador, Brazil. Wanderson Kleber de Oliveira and Marilia Lavocat Nunes are with Ministry of Health, Brasilia, Brazil. Laura C. Rodrigues is with London School of Hygiene and Tropical Medicine, London, England.",,,,,,"We describe the epidemic of microcephaly in Brazil, its detection and attempts to control it, the suspected causal link with Zika virus infection during pregnancy, and possible scenarios for the future. In October 2015, in Pernambuco, Brazil, an increase in the number of newborns with microcephaly was reported. Mothers of the affected newborns reported rashes during pregnancy and no exposure to other potentially teratogenic agents. Women delivering in October would have been in the first trimester of pregnancy during the peak of a Zika epidemic in March. By the end of 2015, 4180 cases of suspected microcephaly had been reported. Zika spread to other American countries and, in February 2016, the World Health Organization declared the Zika epidemic a public health emergency of international concern. This unprecedented situation underscores the urgent need to establish the evidence of congenital infection risk by gestational week and accrue knowledge. There is an urgent call for a Zika vaccine, better diagnostic tests, effective treatment, and improved mosquito-control methods.",Pubmed,March 31, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Yes,Original research,No,Yes,443,Clinical/epidemiological research,Ecological study/outbreak report
444,"Duchin, Disaster Med Public Health Prep, 2016",Duchin,"Duchin, J. S.",US Public Health Preparedness for Zika and Other Threats Remains Vulnerable,Disaster Med Public Health Prep,10,2,298-9,2016,2010-present,March 10, 2016,26952646,10.1017/dmp.2016.26,1173,English,,"1Health Officer and Chief,Communicable Disease Epidemiology & Immunization Section,Public Health - Seattle & King County.",,,,,"Zika, emergency preparedness, emerging infection, foundational capacities, public health","The unanticipated global outbreak of Zika virus infection is the most current but certainly not the last emerging infectious disease challenge to confront the US public heath system. Despite a number of such threats in recent years, significant gaps remain in core areas of public health system readiness. Stable, sustained investments are required to establish a solid foundation for achieving necessary national public health emergency preparedness and response capacity. (Disaster Med Public Health Preparedness. 2016;10:298-299).",Pubmed,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,444,,
445,"Mayor, BMJ, 2016",Mayor,"Mayor, S.","Zika infection in pregnancy is linked to range of fetal abnormalities, data indicate",BMJ,352,,i1362,2016,2010-present,March 10, 2016,26951804,10.1136/bmj.i1362,1176,English,,London.,,,,,,,Pubmed,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,News item or lay press,,,No,Yes,445,,
446,"Hodge, Disaster Med Public Health Prep, 2016",Hodge,"Hodge, J. G., Corbett, A., Repka, A., Judd, P. J.",Zika Virus and Global Implications for Reproductive Health Reforms,Disaster Med Public Health Prep,,,01. Mrz,2016,2010-present,March 10, 2016,26957316,10.1017/dmp.2016.34,1167,English,,"Sandra Day O'Connor College of Law,Arizona State University,Tempe,Arizona.",,,,,,"The rapid global spread of Zika virus, especially in developing countries in Latin America, presents new and significant risks to the public's health, notably among pregnant women and their infants. Zika virus is predominantly spread via the Aedes species of mosquitos, but sexual transmission between infected males and their female partners has also been shown. While related morbidity of Zika virus remains uncertain, credible evidence is growing of the link between infection of women and potentially disabling mental and physical impairments of their fetuses. Public health scientists are virtually sure that increased rates of microcephaly (abnormally small skulls and brains) among thousands of Brazilian infants over the past several months are tied to Zika infection. New evidence of vision, hearing, and long-term mental health disabilities among Zika-affected babies is also mounting.",Pubmed,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,446,,
447,"[No authors listed], Am J Perinatol, 2016",[No authors listed],[No authors listed],Zika Virus and Pregnancy: A Review of the Literature and Clinical Considerations (Podcast),Am J Perinatol,,,,2016,2010-present,March 10, 2016,26951454,10.1055/s-0036-1580699,1177,English,http://www.ncbi.nlm.nih.gov/pubmed/26951454,,,,,,,"The latest Zika virus (ZIKV) outbreak has reached epidemic proportions as it spreads throughout South and Central America. In November 2015, the Brazilian Ministry of Health reported a 20-fold increase in the number of cases of neonatal microcephaly, which corresponds geographically and temporally to the ZIKV outbreak. Case reports have provided some evidence of a causal link between maternal ZIKV infection, fetal microcephaly, and intracranial calcifications. The sparse data regarding ZIKV in pregnancy come solely from case reports and personal communications, and recommendations for management of ZIKV exposure during pregnancy are rapidly evolving. Our objective is to review and synthesize the current literature regarding ZIKV as it pertains to pregnancy and provide some assistance to clinicians who may have to manage a pregnant patient with potential exposure to ZIKV. We will also explore certain aspects of related viruses in pregnancy in hopes to shed light on this little-known topic.",Pubmed,March 31, 2016,No,Duplicate of existing record,,,,,,,,,,
448,"Broutet, N Engl J Med, 2016",Broutet,"Broutet, N., Krauer, F., Riesen, M., Khalakdina, A., Almiron, M., Aldighieri, S., Espinal, M., Low, N., Dye, C.",Zika Virus as a Cause of Neurologic Disorders,N Engl J Med,,,,2016,2010-present,March 10, 2016,26959308,10.1056/NEJMp1602708,1159,English,,"From the World Health Organization, Geneva (N.B., A.K., C.D.), and the Institute of Social and Preventive Medicine, University of Bern, Bern (F.K., M.R., N.L.) - both in Switzerland; and the Pan American Health Organization, Washington, DC (M.A., S.A., M.E.).",,,,,,"Zika virus infections have been known in Africa and Asia since the 1940s, but the virus's geographic range has expanded dramatically since 2007. Between January 1, 2007, and March 1, 2016, local transmission was reported in an additional 52 countries and territories, mainly in the Americas and the western Pacific, but also in Africa and southeast Asia. Zika virus infections acquired by travelers visiting those countries have been discovered at sites worldwide. Aedes aegypti mosquitoes are the principal vectors, though other mosquito species may contribute to transmission. The virus was found to be neurotropic in animals in experiments conducted in . . .",Pubmed,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,No,Comment/Editorial/Perspective/Letter,No,Yes,448,,
449,"Carteaux, N Engl J Med, 2016",Carteaux,"Carteaux, G., Maquart, M., Bedet, A., Contou, D., Brugieres, P., Fourati, S., Cleret de Langavant, L., de Broucker, T., Brun-Buisson, C., Leparc-Goffart, I., Mekontso Dessap, A.",Zika Virus Associated with Meningoencephalitis,N Engl J Med,,,,2016,2010-present,March 10, 2016,26958738,10.1056/NEJMc1602964,1166,English,,"Assistance Publique-Hopitaux de Paris, Creteil, France guillaume.carteaux@yahoo.fr., French Armed Forces Biomedical Research Institute, Marseille, France., Assistance Publique-Hopitaux de Paris, Creteil, France., Centre Hospitalier de Saint-Denis, Saint-Denis, France., Universite Paris Est Creteil, Creteil, France.",France,Europe,France,No funding received,,"To the Editor: Zika virus (ZIKV) is currently spreading widely, while its clinical spectrum remains a matter of investigation. Evidence of a relationship between ZIKV infection and cerebral birth abnormalities1,2 is growing.3 An increased incidence of some peripheral nervous syndromes among adults was reported during outbreaks in French Polynesia4,5 and Brazil,1,2 but no formal link with ZIKV infection was shown. We describe a case of central nervous system infection with ZIKV that was associated with meningoencephalitis in an adult. An 81-year-old man was admitted to the intensive care unit (ICU) 10 days after he had been on . . .",Pubmed,March 31, 2016,Yes,,No,"Zika, indirect evidence or other topic",Scientific (journal) article,Yes,Original research,No,Yes,449,Clinical/epidemiological research,Case report
450,"Lee, J Korean Med Sci, 2016",Lee,"Lee, J.",Zika virus Infection: New Threat in Global Health,J Korean Med Sci,31,3,331-2,2016,2010-present,March 10, 2016,26955231,10.3346/jkms.2016.31.3.331,1169,English,,"Division of Infectious Disease, College of Medicine, Hallym University, Seoul, Korea .",,,,,,,Pubmed,March 31, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,450,,
451,"Tang, Cell Stem Cell, 2016",Tang,"Tang, H.; Hammack, C.; Ogden, S. C.; Wen, Z.; Qian, X.; Li, Y.; Yao, B.; Shin, J.; Zhang, F.; Lee, E. M.; Christian, K. M.; Didier, R. A.; Jin, P.; Song, H.; Ming, G. L.",Zika Virus Infects Human Cortical Neural Progenitors and Attenuates Their Growth,Cell Stem Cell,,,,2016,2010-present,March 10, 2016,26952870,10.1016/j.stem.2016.02.016,1171,English,http://www.ncbi.nlm.nih.gov/pubmed/26952870,"Department of Biological Science, Florida State University, Tallahassee, FL 32306, USA. Electronic address: tang@bio.fsu.edu.; Department of Biological Science, Florida State University, Tallahassee, FL 32306, USA.; Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21025, USA; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21025, USA.; Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21025, USA; Biomedical Engineering Graduate Program, Johns Hopkins University School of Medicine, Baltimore, MD 21025, USA.; Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA.; Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21025, USA; Cellular and Molecular Medicine Graduate Program, Johns Hopkins University School of Medicine, Baltimore, MD 21025, USA.; College of Medicine, Florida State University, Tallahassee, FL 32306, USA.; Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21025, USA; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21025, USA; Cellular and Molecular Medicine Graduate Program, Johns Hopkins University School of Medicine, Baltimore, MD 21025, USA; Solomon Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21025, USA; Kavli Neuroscience Discovery Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21025, USA. Electronic address: shongju1@jhmi.edu.; Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21025, USA; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21025, USA; Cellular and Molecular Medicine Graduate Program, Johns Hopkins University School of Medicine, Baltimore, MD 21025, USA; Solomon Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21025, USA; Kavli Neuroscience Discovery Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21025, USA; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21025, USA. Electronic address: gming1@jhmi.edu.",United States,Americas,United States,Mixed,,"The suspected link between infection by Zika virus (ZIKV), a re-emerging flavivirus, and microcephaly is an urgent global health concern. The direct target cells of ZIKV in the developing human fetus are not clear. Here we show that a strain of the ZIKV, MR766, serially passaged in monkey and mosquito cells efficiently infects human neural progenitor cells (hNPCs) derived from induced pluripotent stem cells. Infected hNPCs further release infectious ZIKV particles. Importantly, ZIKV infection increases cell death and dysregulates cell-cycle progression, resulting in attenuated hNPC growth. Global gene expression analysis of infected hNPCs reveals transcriptional dysregulation, notably of cell-cycle-related pathways. Our results identify hNPCs as a direct ZIKV target. In addition, we establish a tractable experimental model system to investigate the impact and mechanism of ZIKV on human brain development and provide a platform to screen therapeutic compounds.",Pubmed,March 31, 2016,Yes,,Yes,,Scientific (journal) article,Yes,Original research,No,Yes,451,Basic and applied biomedical research,In vitro experiment
452,"Zumla, Int J Infect Dis, 2016",Zumla,"Zumla, A.; Goodfellow, I.; Kasolo, F.; Ntoumi, F.; Buchy, P.; Bates, M.; Azhar, E. I.; Cotten, M.; Petersen, E.",Zika virus outbreak and the case for building effective and sustainable rapid diagnostics laboratory capacity globally,Int J Infect Dis,45,,92-94,2016,2010-present,March 10, 2016,26952389,10.1016/j.ijid.2016.02.1007,1175,English,http://www.ncbi.nlm.nih.gov/pubmed/26952389,"Division of Infection and Immunity, University College London and NIHR Biomedical Research Centre, UCLHospitals NHS Foundation Trust, London, UK. Electronic address: a.i.zumla@gmail.com.; Division of Virology, Department of Pathology, University of Cambridge, Addenbrooke's Hospital, Hills Road, Cambridge UK and School of Public Health, University of Makeni, Sierra Leone. Electronic address: ig299@cam.ac.uk.; Country and Inter-country Support, Office of the Regional Director, WHO- AFRO, Brazzaville, Republic of Congo. Electronic address: kasolof@who.int.; Fondation Congolaise pour la Recherche Medicale and University Marien Ngouabi, Brazzaville, Republic of Congo, and Institute for Tropical Medicine, University of Tubingen, Germany. Electronic address: fntoumi@fcrm-congo.com.; GlaxoSmithKline Vaccines, R&D Asia-Pacific, Gateway West, Singapore. Electronic address: philippe.x.buchy@gsk.com.; UNZA-UCLMS Research and Training Project, University Teaching Hospital, Lusaka, Zambia. Electronic address: matthew.bates@ucl.ac.uk.; Special Infectious Agents Unit, King Fahd Medical Research Centre, and Medical Laboratory Technology Department, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia. Electronic address: eazhar@kau.edu.sa.; The Wellcome Trust Sanger Institute, Cambridge, UK. Electronic address: mc13@sanger.ac.uk.; University of Aarhus, Denmark and The Royal Hospital, Muscat, Oman. Electronic address: eskildp@dadlnet.dk.",,,,,Emerging pathogens; Zika virus; diagnostics; laboratory; public health; surveillance,,Pubmed,March 31, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,No,Comment/Editorial/Perspective/Letter,No,Yes,452,,
453,"Ai, Emerg Microbes Infect, 2016",Ai,"Ai, J. W., Zhang, Y., Zhang, W.",Zika virus outbreak: 'a perfect storm',Emerg Microbes Infect,5,,e21,2016,2010-present,March 10, 2016,26956448,10.1038/emi.2016.42,1168,English,,"Department of Infectious Diseases, Huashan Hospital, Fudan University, Shanghai 200040, China., Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA., MOH and MOE Key Laboratory of Medical Molecular Virology, Shanghai Medical College, Fudan University, Shanghai 200032, China.",,,,,,"Zika virus, a once-overlooked single-stranded ribonucleic acid (RNA) virus that causes a mosquito-borne viral disease, is causing a major ongoing pandemic worldwide. On 1 February 2016, the World Health Organization declared Zika virus-associated clusters of microcephaly and related neurological disorders a 'Public Health Emergency of International Concern'.1 Why has a largely ignored virus, which normally causes only mild symptoms, reemerged with a different pathophysiology, much like an unpredicted storm?",Pubmed,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,No,Comment/Editorial/Perspective/Letter,No,Yes,453,,
454,"Borchardt, Jaapa, 2016",Borchardt,"Borchardt, R. A.",Zika virus: A rapidly emerging infectious disease,Jaapa,29,4,48-50,2016,2010-present,March 10, 2016,26953673,10.1097/01.JAA.0000481413.11539.b1,1170,English,,"Roy A. Borchardt is supervisor of advanced practice providers in the Department of Infectious Diseases, Infection Control, and Employee Health at MD Anderson Cancer Center in Houston, Tex. The author has disclosed no potential conflicts of interest, financial or otherwise.",,,,,,"Zika virus is a flavivirus transmitted to humans via the bite of infected mosquitoes. A recent outbreak in Brazil has spread to several surrounding countries, and the virus also has been reported in the United States. The virus is associated with microcephaly among newborns whose mothers were infected. Because no vaccine or treatment is available, efforts have focused on preventing mosquito bites and advising pregnant women and women trying to get pregnant to avoid active areas of Zika virus transmission. Clinicians should understand the infection, its diagnosis and testing, and monitor pregnant women for travel history to outbreak regions and for the presence of clinical symptoms. Patient education on preventive measures offers the best option to avoid Zika virus infection.",Pubmed,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,No,Comment/Editorial/Perspective/Letter,No,Yes,454,,
455,"Burkle, Disaster Med Public Health Prep, 2016",Burkle,"Burkle, F. M.",Zika: Defining the Public Health and Exposing its Vulnerabilities,Disaster Med Public Health Prep,10,2,296-7,2016,2010-present,March 10, 2016,26952701,10.1017/dmp.2016.27,1172,English,,"1Senior International Public Policy Scholar,Woodrow Wilson International Center for Scholars,Washington,DC.",,,,,,,Pubmed,March 31, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,455,,
456,"Rodrigues, Am J Public Health, 2016",Rodrigues,"Rodrigues, L. C.",Zika: The Tragedy and the Opportunities,Am J Public Health,106,4,582,2016,2010-present,March 10, 2016,26959248,10.2105/ajph.2016.303114,1164,English,,"London School of Hygiene and Tropical Medicine London, UK.",,,,,,,Pubmed,March 31, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,No,Comment/Editorial/Perspective/Letter,No,Yes,456,,
457,"Villamil-Gomez, Travel Med Infect Dis, 2016",Villamil-Gomez,"Villamil-Gomez, W. E.; Mendoza-Guete, A.; Villalobos, E.; Gonzalez-Arismendy, E.; Uribe-Garcia, A. M.; Castellanos, J. E.; Rodriguez-Morales, A. J.","Diagnosis, management and follow-up of pregnant women with Zika virus infection: A preliminary report of the ZIKERNCOL cohort study on Sincelejo, Colombia",Travel Med Infect Dis,14,2,155-158,2016,2010-present,March 11, 2016,26960750,10.1016/j.tmaid.2016.02.004,1155,English,http://www.ncbi.nlm.nih.gov/pubmed/26960750,"Infectious Diseases and Infection Control Research Group, Hospital Universitario de Sincelejo, Sincelejo, Sucre, Colombia; Programa del Doctorado de Medicina Tropical, Universidad de Cartagena, Cartagena, Universidad del Atlantico, Barranquilla, Colombia; Committee on Travel Medicine, Pan-American Association of Infectious Diseases, Quito, Ecuador; Committee on Zoonoses and Haemorrhagic Fevers, Asociacion Colombiana de Infectologia, Bogota, DC, Colombia.; Department of Gynecology, Hospital Universitario de Sincelejo, Sincelejo, Sucre, Colombia.; Department of Gynecology, Clinica Santa Maria, Sincelejo, Sucre, Colombia.; Grupo de Virologia, Universidad El Bosque, Bogota, DC, Colombia.; Infectious Diseases and Infection Control Research Group, Hospital Universitario de Sincelejo, Sincelejo, Sucre, Colombia; Committee on Travel Medicine, Pan-American Association of Infectious Diseases, Quito, Ecuador; Committee on Zoonoses and Haemorrhagic Fevers, Asociacion Colombiana de Infectologia, Bogota, DC, Colombia; Working Group on Zoonoses, International Society for Chemotherapy, Aberdeen, UK; Public Health and Infection Research Incubator and Group, Faculty of Health Sciences, Universidad Tecnologica de Pereira, Pereira, Risaralda, Colombia. Electronic address: arodriguezm@utp.edu.co.",Colombia,Americas,Colombia,Public/Government,Colombia; Epidemiology; Latin America; Pregnancy; Zika,"Zika virus infection (ZIKV) has emerged as a significant threat for the health of pregnant women and newborns in populations living or visiting Latin America since the epidemic begun in 2015. Reported possible consequences included particularly the risk of associated microcephaly and other congenital defects. In this Setting the consequences of ZIKV during pregnancy, a retrospective preliminary analysis of a cohort of pregnant women with RT-PCR confirmed ZIKV is presented ",Pubmed,March 31, 2016,Yes,,Yes,,Scientific (journal) article,Yes,Original research,No,Yes,457,Clinical/epidemiological research,Case series
458,"Butler, Nature, 2016",Butler,"Butler, D.",First Zika-linked birth defects detected in Colombia,Nature,531,7593,153,2016,2010-present,March 11, 2016,26961637,10.1038/nature.2016.19502,1153,English,http://www.ncbi.nlm.nih.gov/pubmed/26961637,,,,,,,,Pubmed,March 31, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",News item or lay press,,,No,Yes,458,,
459,"Waltz, Nat Biotechnol, 2016",Waltz,"Waltz, E.",GM mosquitoes fire first salvo against Zika virus,Nat Biotechnol,34,3,221-2,2016,2010-present,March 11, 2016,26963535,10.1038/nbt0316-221,1148,English,http://www.ncbi.nlm.nih.gov/pubmed/26963535,,,,,,,,Pubmed,March 31, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",News item or lay press,,,No,Yes,459,,
460,"Kleber de Oliveira, MMWR Morb Mortal Wkly Rep, 2016",Kleber de Oliveira,"Kleber de Oliveira, W.; Cortez-Escalante, J.; De Oliveira, W. T.; do Carmo, G. M.; Henriques, C. M.; Coelho, G. E.; Araujo de Franca, G. V.","Increase in Reported Prevalence of Microcephaly in Infants Born to Women Living in Areas with Confirmed Zika Virus Transmission During the First Trimester of Pregnancy - Brazil, 2015",MMWR Morb Mortal Wkly Rep,65,9,242-7,2016,2010-present,March 11, 2016,26963593,10.15585/mmwr.mm6509e2,1146,English,http://www.ncbi.nlm.nih.gov/pubmed/26963593,,Brazil,Americas,Brazil,Not reported/unknown,,"Widespread transmission of Zika virus by Aedes mosquitoes has been recognized in Brazil since late 2014, and in October 2015, an increase in the number of reported cases of microcephaly was reported to the Brazil Ministry of Health.* By January 2016, a total of 3,530 suspected microcephaly cases had been reported, many of which occurred in infants born to women who lived in or had visited areas where Zika virus transmission was occurring. Microcephaly surveillance was enhanced in late 2015 by implementing a more sensitive case definition. Based on the peak number of reported cases of microcephaly, and assuming an average estimated pregnancy duration of 38 weeks in Brazil (1), the first trimester of pregnancy coincided with reports of cases of febrile rash illness compatible with Zika virus disease in pregnant women in Bahia, Paraiba, and Pernambuco states, supporting an association between Zika virus infection during early pregnancy and the occurrence of microcephaly. Pregnant women in areas where Zika virus transmission is occurring should take steps to avoid mosquito bites. Additional studies are needed to further elucidate the relationship between Zika virus infection in pregnancy and microcephaly.",Pubmed,March 31, 2016,Yes,,Yes,,Scientific (journal) article,No,Original research,Yes,No,912,Clinical/epidemiological research,Ecological study/outbreak report
461,"Marks, J Infect Dis, 2016",Marks,"Marks, P. W.; Epstein, J. S.; Borio, L.",Maintaining a safe blood supply in an era of emerging pathogens,J Infect Dis,,,,2016,2010-present,March 11, 2016,26962237,10.1093/infdis/jiw089,1149,English,http://www.ncbi.nlm.nih.gov/pubmed/26962237,,,,,,,"Coming shortly after outbreaks of dengue and chikungunya virus in related locations, the recent outbreak of Zika virus in the southern part of the Western Hemisphere is yet another reminder that infectious pathogens continue to emerge rapidly and can adversely impact the public health, including the safety of the blood supply. In response to Zika virus, public health measures that rely largely on donor deferral and sourcing of blood from non-outbreak areas until a blood donor screening test becomes available have been implemented to address the safety of the blood supply in the United States. However, a more universal approach to assuring blood safety in the setting of rapidly emerging infectious diseases is needed.",Pubmed,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,No,Comment/Editorial/Perspective/Letter,No,Yes,461,,
462,"Lazear, JAMA, 2016",Lazear,"Lazear, H. M.; Stringer, E. M.; de Silva, A. M.",The Emerging Zika Virus Epidemic in the Americas: Research Priorities,JAMA,,,,2016,2010-present,March 11, 2016,26963564,10.1001/jama.2016.2899,1147,English,http://www.ncbi.nlm.nih.gov/pubmed/26963564,"Department of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill.; Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of North Carolina School of Medicine, Chapel Hill3Institute for Global Health and Infectious Diseases, University of North Carolina, Chapel Hill.; Department of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill3Institute for Global Health and Infectious Diseases, University of North Carolina, Chapel Hill.",,,,,,,Pubmed,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,No,Comment/Editorial/Perspective/Letter,No,Yes,462,,
463,"Paixao, Br J Hosp Med (Lond), 2016",Paixao,"Paixao, E. S., Rodrigues, L. C.",What we need to know about Zika virus,Br J Hosp Med (Lond),77,3,124-5,2016,2010-present,March 11, 2016,26961437,10.12968/hmed.2016.77.3.124,1154,English,,"PhD Candidate in the Department of Infectious Disease, London School of Hygiene and Tropical Medicine, London WC1E 7HT., Professor in the Department of Infectious Disease, London School of Hygiene and Tropical Medicine, London.",,,,,,,Pubmed,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,463,,
464,"Liuzzi, New Microbiol, 2016",Liuzzi,"Liuzzi, G., Puro, V., Vairo, F., Nicastri, E., Capobianchi, M. R., Di Caro, A., Piacentini, M., Zumla, A., Ippolito, G.","Zika virus and microcephaly: is the correlation, causal or coincidental?",New Microbiol,39,2,,2016,2010-present,March 11, 2016,26960598,,1156,English,,"National Institute for Infectious Diseases 'Lazzaro Spallanzani'-IRCCS Via Portuense, 292- 00149 Rome, Italy., Division of Infection and Immunity, University College London, and NIHR Biomedical Research Centre, UCL Hospitals NHS Foundation Trust, London, UK.",,,,,,,Pubmed,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Yes,Review,No,Yes,464,Clinical/epidemiological research,Epidemiological/clinical review
465,"Kirk, Nature, 2016",Kirk,"Kirk, E. P.",Zika virus: accurate terminology matters,Nature,531,7593,173,2016,2010-present,March 11, 2016,26961646,10.1038/531173b,1152,English,,"Sydney Children's Hospital; University of New South Wales; and SEALS Laboratories, Randwick, Australia.",,,,,"Aedes/*virology, Animals, Female, Humans, Mosquito Control/*methods, Pregnancy, Virology/*trends, Zika Virus/*pathogenicity, Zika Virus Infection/*epidemiology",,Pubmed,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,465,,
466,"Scheuermann, Nature, 2016",Scheuermann,"Scheuermann, R. H.",Zika virus: designate standardized names,Nature,531,7593,173,2016,2010-present,March 11, 2016,26961650,10.1038/531173a,1151,English,,"J. Craig Venter Institute, La Jolla, California, USA.",,,,,,,Pubmed,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,466,,
467,"Lazear, J Virol, 2016",Lazear,"Lazear, H. M., Diamond, M. S.",Zika Virus: New Clinical Syndromes and its Emergence in the Western Hemisphere,J Virol,,,,2016,2010-present,March 11, 2016,26962217,10.1128/jvi.00252-16,1150,English,,"Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599. helen.lazear@med.unc.edu., Departments of Medicine, Molecular Microbiology, Pathology & Immunology, and The Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, St Louis, MO 63110. diamond@borcim.wustl.edu.",,,,,,"Zika virus (ZIKV) had remained a relatively obscure flavivirus until a recent series of outbreaks accompanied by unexpectedly severe clinical complications brought this virus into the spotlight as an infection of global public health concern. In this review, we discuss the history and epidemiology of ZIKV infection, recent outbreaks in Oceania and the emergence of ZIKV in the Western Hemisphere, newly ascribed complications of ZIKV infection including Guillain-Barré syndrome and microcephaly, potential interactions between ZIKV and dengue virus, and the prospects for the development of antiviral agents and vaccines. ",Pubmed,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Yes,Review,No,Yes,467,Clinical/epidemiological research,Epidemiological/clinical review
468,"Cofre, Rev Chilena Infectol, 2016",Cofre,"Cofre, F.",[Zika virus intrauterine infection causes fetal brain abnormality and microcephaly: tip of the iceberg?],Rev Chilena Infectol,33,1,96,2016,2010-present,March 12, 2016,26965888,10.4067/s0716-10182016000100018,1141,Spanish,,,,,,,,,Pubmed,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,468,,
469,"Bull World Health Organ, Bull World Health Organ, 2016",Bull World Health Organ,Bull World Health Organ,Brazil's scientists scramble to solve the Zika puzzle,Bull World Health Organ,94,3,165-6,2016,2010-present,March 12, 2016,26966326,10.2471/BLT.16.030316,1139,English,http://www.ncbi.nlm.nih.gov/pubmed/26966326,,,,,,,The World Health Organization has declared the recent leap in the number of microcephaly cases and their suspected association with Zika virus a public health emergency of international concern. Ana Bispo tells Andreia Azevedo Soares why Brazil should have some scientific answers in coming months.,Pubmed,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,News item or lay press,,,No,Yes,469,,
470,"Scully, Br Dent J, 2016",Scully,"Scully, C.; Robinson, A.",Check before you travel: Zika virus - another emerging global health threat,Br Dent J,220,5,265-7,2016,2010-present,March 12, 2016,26964604,10.1038/sj.bdj.2016.182,1145,English,http://www.ncbi.nlm.nih.gov/pubmed/26964604,"University College London, London;; National University of Singapore.",,,,,,"We now know that mosquitoes can transmit arboviruses such as the Zika virus (ZIKV) which is pandemic in Latin America. In order to avoid infection it is advised to avoid mosquitoes, but ZIKV can also be transmitted through blood donation, perinatally and sexually and has been detected in urine and saliva. Prevention against mosquito bites (particularly daytime bites) is best offered by avoiding mosquitoes and bites. To prevent the risk of transmission of ZIKV, standard infection control of all recent travellers to Zika affected areas should be conducted during dental care. This article will discuss how healthcare workers could contract diseases especially whilst working in the tropics or subtropics due to disease vectors such as mosquitoes and suggests prevention measures for this group.",Pubmed,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,470,,
471,"Vogel, Science, 2016",Vogel,"Vogel, G.",INFECTIOUS DISEASE. Evidence grows for Zika virus as pregnancy danger,Science,351,6278,1123-4,2016,2010-present,March 12, 2016,26965596,10.1126/science.351.6278.1123,1142,English,http://www.ncbi.nlm.nih.gov/pubmed/26965596,,,,,,"Brain/*abnormalities/*virology; Female; Humans; Infant; Microcephaly/*virology; Pregnancy; Pregnancy Complications, Infectious/*virology; World Health Organization; *Zika Virus; Zika Virus Infection/*complications","Since late last year when physicians in Brazil warned that a wave of serious birth defects might be linked to a little-known virus called Zika, researchers have struggled to prove the connection. Some in the media have questioned whether the reported increase in birth defects is real; others, particularly environmental activists, have suggested the virus is an innocent bystander, unfairly blamed for defects caused by chemicals or other factors. With three studies published last week, chances that the virus has been wrongly accused are fading. Two independent groups showed that, at least in the lab, the virus eagerly infects developing brain cells, suggesting a mechanism by which it could cause the most striking of the observed birth defects: microcephaly, in which babies are born with abnormally small heads and brains. A third study, following several dozen pregnant women in Brazil who were infected with the virus, directly links the infection to an increase in brain defects. It also suggests that the virus can harm a developing fetus in other ways, possibly by attacking the placenta and slowing down the supply of nutrients. 'These are the data we have been waiting for,' says Daniel Lucey, an expert on global health at Georgetown University in Washington, D.C.",Pubmed,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,471,,
472,"Gulland, BMJ, 2016",Gulland,"Gulland, A.",WHO strengthens Zika travel advice to pregnant women,BMJ,352,,i1460,2016,2010-present,March 12, 2016,26965035,10.1136/bmj.i1460,1144,English,,London.,,,,,,,Pubmed,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,News item or lay press,,,No,Yes,472,,
473,"Roze, Eurosurveillance, 2016",Roze,"Roze, B., Najioullah, F., Ferge, J. L., Apetse, K., Brouste, Y., Cesaire, R., Fagour, C., Fagour, L., Hochedez, P., Jeannin, S., Joux, J., Mehdaoui, H., Valentino, R., Signate, A., Cabie, A.","Zika virus detection in urine from patients with Guillain-Barre syndrome on Martinique, January 2016",Eurosurveillance,21,9,,2016,2010-present,March 12, 2016,26967758,10.2807/1560-7917.es.2016.21.9.30154,1138,English,,"Infectious and Tropical diseases Unit, Universitary Hospital of Martinique, Fort de France, France.",France,Europe,France,Not reported/unknown,"Martinique, emerging or re-emerging diseases, outbreaks, vector-borne infections, viral infections","We report two cases of Guillain-Barre syndrome who had concomitant Zika virus viruria. This viruria persisted for longer than 15 days after symptom onset. The cases occurred on Martinique in January 2016, at the beginning of the Zika virus outbreak. Awareness of this possible neurological complication of ZikV infection is needed.",Pubmed,March 31, 2016,Yes,,Yes,,Scientific (journal) article,Yes,Original research,No,Yes,473,Clinical/epidemiological research,Case report
474,"Wong, J Formos Med Assoc, 2016",Wong,"Wong, S. S.; Poon, R. W.; Wong, S. C.",Zika virus infection-the next wave after dengue?,J Formos Med Assoc,,,,2016,2010-present,March 12, 2016,26965962,10.1016/j.jfma.2016.02.002,1140,English,http://www.ncbi.nlm.nih.gov/pubmed/26965962,"Department of Microbiology, Research Centre for Infection and Immunology, Faculty of Medicine, The University of Hong Kong, Hong Kong. Electronic address: samsonsy@hku.hk.; Department of Microbiology, Queen Mary Hospital, Hong Kong.",,,,,Aedes; Flavivirus; Zika virus; congenital abnormalities; travel medicine,"Zika virus was initially discovered in east Africa about 70 years ago and remained a neglected arboviral disease in Africa and Southeast Asia. The virus first came into the limelight in 2007 when it caused an outbreak in Micronesia. In the ensuing decade, it spread widely in other Pacific islands, after which its incursion into Brazil in 2015 led to a widespread epidemic in Latin America. In most infected patients the disease is relatively benign. Serious complications include Guillain-Barre syndrome and congenital infection which may lead to microcephaly and maculopathy. Aedes mosquitoes are the main vectors, in particular, Ae. aegypti. Ae. albopictus is another potential vector. Since the competent mosquito vectors are highly prevalent in most tropical and subtropical countries, introduction of the virus to these areas could readily result in endemic transmission of the disease. The priorities of control include reinforcing education of travellers to and residents of endemic areas, preventing further local transmission by vectors, and an integrated vector management programme. The container habitats of Ae. aegypti and Ae. albopictus means engagement of the community and citizens is of utmost importance to the success of vector control.",Pubmed,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,No,Review,No,Yes,474,Clinical/epidemiological research,Epidemiological/clinical review
475,"Liu, Virol Sin, 2016",Liu,"Liu, S. Q., Zhang, B.",Zika virus: a flavivirus caused pandemics in Latin America,Virol Sin,,,,2016,2010-present,March 12, 2016,26965108,10.1007/s12250-016-3738-0,1143,English,,"Key Laboratory of Special Pathogens and Biosafety, Center for Emerging Infectious Diseases, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, 430071, China., Key Laboratory of Special Pathogens and Biosafety, Center for Emerging Infectious Diseases, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, 430071, China. zhangbo@wh.iov.cn.",,,,,,,Pubmed,March 31, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",News item or lay press,,,No,Yes,475,,
476,"Papageorghiou, Ultrasound Obstet Gynecol, 2016",Papageorghiou,"Papageorghiou, A. T.; Thilaganathan, B.; Bilardo, C. M.; Ngu, A.; Malinger, G.; Herrera, M.; Salomon, L. J.; Riley, L. E.; Copel, J. A.",ISUOG Interim Guidance on ultrasound for Zika virus infection in pregnancy: information for healthcare professionals,Ultrasound Obstet Gynecol,,,,2016,2010-present,March 13, 2016,26969966,10.1002/uog.15896,1135,English,http://www.ncbi.nlm.nih.gov/pubmed/26969966,"Fetal Medicine Unit, St George's University Foundation Hospitals NHS Trust, London, UK.; Nuffield Department of Obstetrics and Gynaecology, University of Oxford, Oxford, UK.; Department of Obstetrics, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands.; East Melbourne Ultrasound, East Melbourne, VIC, Australia.; Division of Ultrasound in Obstetrics & Gynecology, Lis Maternity Hospital, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.; Maternal Fetal Medicine Department, Colombian University Clinic, Colsanitas Clinic, Bogota, Colombia.; Department of Obstetrics and Maternal-Fetal Medicine, Necker-Enfants Malades Hospital, Assistance Publique-Hopitaux de Paris, Universite Paris Descartes, Paris, France.; Obstetrics and Gynecology, Massachusetts General Hospital, Boston, MA, USA.; Department of Obstetrics, Gynecology and Reproductive Sciences, Yale School of Medicine, New Haven, CT, USA.",,,,,,,Pubmed,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Yes,Other,No,Yes,476,,
477,"Imperato, J Community Health, 2016",Imperato,"Imperato, P. J.","The Convergence of a Virus, Mosquitoes, and Human Travel in Globalizing the Zika Epidemic",J Community Health,,,,2016,2010-present,March 13, 2016,26969497,10.1007/s10900-016-0177-7,1137,English,http://www.ncbi.nlm.nih.gov/pubmed/26969497,"Downstate Medical Center, School of Public Health, State University of New York, 450 Clarkson Avenue, MSC 43, Brooklyn, NY, 11203, USA. pascal.imperato@downstate.edu.",,,,,Aedes aegypti; Guillain-Barre syndrome; Kisubi Catholic Mission; Microcephaly; Zika Forest and Pascal James Imperato; Zika virus; Zika virus and travel; Zika virus infection,"The Zika virus was first identified in 1947 in the Zika Forest of Uganda. It was discovered in a rhesus monkey that had been placed in a cage on a sentinel platform in the forest by the Virus Research Institute. When this writer visited the institute and the Zika Forest in 1961, work was underway to identify mosquito species at various levels of the tree canopy. This was done through the placement of traps at various levels of a 120-foot-high steel tower which this writer climbed. At that time, researchers isolated 12 strains of Zika virus from traps on the tower. Over the next six decades, the virus spread slowly to other parts of Africa, and eventually appeared in Southeast Asia, transmitted by Aedes aegypti and other Aedes mosquito species. By 1981, only 14 cases of illness had been reported as due to the Zika virus. Since most infections with this virus are either mild or asymptomatic, its true geographic spread was not fully appreciated. The current globalization of the Zika epidemic began on the Pacific island of Yap in the Federated States of Polynesia in 2007. This was the first known presence of the Zika virus outside of Africa and Southeast Asia. It was estimated that 73 % of the island's population had been infected. In 2013, the virus spread to French Polynesia where an estimated 28,000 cases occurred in a population of 270,000. During that year and afterwards, microcephaly and other congenital abnormalities were observed in the infants of women who were pregnant when they contracted the virus. It is currently not known if cases of microcephaly have resulted from infection of pregnant women or from infection plus some other co-factor. The epidemic rapidly spread to the Cook Islands and Easter Island. In 2015, Zika virus infection was diagnosed in Brazil where it was associated with microcephaly in the infants of some women who were pregnant when they contracted the disease. Cases of the Guillain-Barre syndrome were also found to be associated with Zika virus infection. How the disease entered Brazil is a matter of conjecture. However, the strain responsible for the epidemic in Brazil and elsewhere in South and Central America is phylogenetically identical to that which caused the epidemic in French Polynesia. The wide distribution of Aedes aegypti, a principal vector of the virus, and other Aedes species has greatly facilitated the spread of the disease. Aedes aegypti is an invasive species of mosquito in the Western Hemisphere that has adapted well to densely-populated urban environments. In addition, male-to-female human sexual transmission has increasingly been demonstrated in the US and elsewhere. In February 2016, the World Health Organization (WHO) declared the current Zika outbreak a Public Health Emergency of international concern. On the recommendation of its Emergency Committee on Zika Virus and Observed Increase in Neurological Disorders and Neonatal Malformations, WHO issued a group of recommendations to contain the epidemic. The globalization of the Zika virus was made possible by the widespread presence in various parts of the world of Aedes vectors and increased human travel that facilitated geographic spread. This globalization of Zika follows upon that of West Nile, Ebola, Dengue, and Chikungunya. Its ultimate spread is difficult to predict, but will hopefully be restricted through vigorous preventive measures.",Pubmed,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,477,,
478,"Kashima, Rev Bras Hematol Hemoter, 2016",Kashima,"Kashima, S., Slavov, S. N., Covas, D. T.",Zika virus and its implication in transfusion safety,Rev Bras Hematol Hemoter,38,1,90-1,2016,2010-present,March 13, 2016,26969782,10.1016/j.bjhh.2016.01.002,1136,English,,"Universidade de Sao Paulo (USP), Ribeirao Preto, SP, Brazil. Electronic address: skashima@hemocentro.fmrp.usp.br., Universidade de Sao Paulo (USP), Ribeirao Preto, SP, Brazil.",,,,,,,Pubmed,March 31, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,478,,
479,"Villamil-Gomez, J Infect Public Health, 2016",Villamil-Gomez,"Villamil-Gomez, W. E., Rodriguez-Morales, A. J.","Reply: Dengue RT-PCR-positive, Chikungunya IgM-positive and Zika RT-PCR-positive co-infection in a patient from Colombia",J Infect Public Health,,,,2016,2010-present,March 14, 2016,26970698,10.1016/j.jiph.2016.02.003,1134,English,,"Infectious Diseases and Infection Control Research Group, Hospital Universitario de Sincelejo, Sincelejo, Sucre, Colombia; Programa del Doctorado de Medicina Tropical, Universidad de Cartagena, Cartagena, Colombia; Universidad del Atlantico, Barranquilla, Colombia; Committee on Zoonoses and Haemorrhagic Fevers, Asociacion Colombiana de Infectologia, Bogota, DC, Colombia., Public Health and Infection Research and Incubator Group, Faculty of Health Sciences, Universidad Tecnologica de Pereira, Pereira, Risaralda, Colombia; Committee on Zoonoses and Haemorrhagic Fevers, Asociacion Colombiana de Infectologia, Bogota, DC, Colombia; Organizacion Latinoamericana para el Fomento de la Investigacion en Salud (OLFIS), Bucaramanga, Santander, Colombia. Electronic address: arodriguezm@utp.edu.co.",,,,,,,Pubmed,March 31, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Unknown/unclear,Original research,No,Yes,479,Clinical/epidemiological research,Case report
480,"Tridane, Travel Med Infect Dis, 2016",Tridane,"Tridane, A., El Khajah, A., Ali, B. R.",The possible threat of Zika virus in the Middle East,Travel Med Infect Dis,,,,2016,2010-present,March 15, 2016,26972490,10.1016/j.tmaid.2016.03.003,1133,English,,"Department of Mathematical Sciences, College of Science, United Arab Emirates University, PO Box 15551, Al Ain, United Arab Emirates. Electronic address: a-tridane@uaeu.ac.ae., Department Biology, College of Science, United Arab Emirates University, Al Ain, United Arab Emirates., Department of Pathology, College of Medicine and Health Sciences, United Arab Emirates University, United Arab Emirates.",,,,,"Congenital microcephaly, Middle East, Travel warning, Zika virus","On February 1st, 2016 the World Health Organization declared Zika virus (ZIKV) as an international public health emergency [1]. This virus was originally identified in Africa [2], spread through Aedes aegypti mosquito. Recently ZIKV has been associated with an increase of cases of newborns with neurological complications such as guillain-barré syndrome and microcephaly in Brazil [3]. Currently, several countries in the Americas, Oceania/Pacific islands and Cape Verde in Africa are considered active ZIKV transmission regions.",Pubmed,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,480,,
481,"The Lancet Infectious, Lancet Infect Dis, 2016",The Lancet Infectious,"The Lancet Infectious, Diseases",Zika virus in the dock,Lancet Infect Dis,16,3,265,2016,2010-present,March 15, 2016,26973301,10.1016/s1473-3099(16)00085-2,1132,English,,,,,,,,,Pubmed,March 31, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,481,,
482,"Frank, EMBO Mol Med, 2016",Frank,"Frank, C.; Faber, M.; Stark, K.",Causal or not: applying the Bradford Hill aspects of evidence to the association between Zika virus and microcephaly,EMBO Mol Med,,,,2016,2010-present,March 16, 2016,26976611,10.15252/emmm.201506058,1130,English,http://www.ncbi.nlm.nih.gov/pubmed/26976611,"Department for Infectious Disease Epidemiology, Robert Koch Institute, Berlin, Germany.",,,,,,,Pubmed,March 31, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,482,,
483,"Basak, Curr Comput Aided Drug Des, 2016",Basak,"Basak, S. C.; Nandy, A.","Editorial: Computer-Assisted Approaches as Decision Support Systems in the Overall Strategy of Combating Emerging Diseases: Some Comments Regarding Drug Design, Vaccinomics, and Genomic Surveillance of the Zika Virus",Curr Comput Aided Drug Des,12,1,02. Apr,2016,2010-present,March 16, 2016,26975308,,1131,English,http://www.ncbi.nlm.nih.gov/pubmed/26975308,"Natural Resources Research Institute and Department of Chemistry & Biochemistry University of Minnesota Duluth Duluth MN 55811 USA. sbasak@nrri.umn.edu.; Centre for Interdisciplinary Research and Education Jodhpur Park Kolkata, 700068 India. anandy43@yahoo.com.",,,,,,,Pubmed,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,483,,
484,"Fry, Surg Infect (Larchmt), 2016",Fry,"Fry, D. E.",Zika Virus Infection and Surgery,Surg Infect (Larchmt),17,2,123,2016,2010-present,March 16, 2016,26978530,10.1089/sur.2016.29004.df,1129,English,,,,,,,,,Pubmed,March 31, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,484,,
485,"Olsen, Lakartidningen, 2016",Olsen,"Olsen, B.; Lundkvist, A.",Zikavirus - gammalt virus far nytt liv i nytt ekosystem - Mikrocefali och Guillain-Barres syndrom mojliga foljder nar bakgrundsimmunitet saknas hos befolkningen.,Lakartidningen,113,,,2016,2010-present,March 16, 2016,26978815,,1128,Other,http://www.ncbi.nlm.nih.gov/pubmed/26978815,"Institutionen for medicinska vetenskaper, infektionssjukdomar - Uppsala universitet Uppsala, Sweden Institutionen for medicinska vetenskaper - Uppsala universitet Uppsala, Sweden.; Uppsala universitetet Institutionen for medicinsk biokemi och mikrobiologi - Uppsala, Sweden Uppsala universitetet Institutionen for medicinsk biokemi och mikrobiologi - Uppsala, Sweden.",,,,,,"Zika virus is a mosquito-borne flavivirus transmitted by Aedes mosquitos. The virus was discovered in 1947 in the Zika forest in Uganda. Symptomatic disease is usually mild and is characterized by maculopapular rash, headache, fever, arthralgia and conjunctivitis. Fatalities are rare. There is neither vaccine nor curative treatment available. In May 2015, the first observation of local virus transmission was reported from Brazil. During the expanding outbreak in the Americas, Zika virus infection has been associated with microcephaly in newborn and fetal losses in women infected with Zika virus during pregnancy. The main reason for the current epidemic in the Americas is the introduction of an Old World virus into a new ecosystem, with no background herd immunity in the population. It is likely that the spread of Zika virus will continue, affecting all countries in the Americas except for Chile and Canada.",Pubmed,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,485,,
486,"Zhu, Emerg Microbes Infect, 2016",Zhu,"Zhu, Z.; Chan, J. F.; Tee, K. M.; Choi, G. K.; Lau, S. K.; Woo, P. C.; Tse, H.; Yuen, K. Y.",Comparative genomic analysis of pre-epidemic and epidemic Zika virus strains for virological factors potentially associated with the rapidly expanding epidemic,Emerg Microbes Infect,5,,e22,2016,2010-present,March 17, 2016,26980239,10.1038/emi.2016.48,1126,English,http://www.ncbi.nlm.nih.gov/pubmed/26980239,"Department of Microbiology, The University of Hong Kong, Hong Kong, China.; State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong, China.; Research Centre of Infection and Immunology, The University of Hong Kong, Hong Kong, China.; Carol Yu Centre for Infection, The University of Hong Kong, Hong Kong, China.",,,,,,"Less than 20 sporadic cases of human Zika virus (ZIKV) infection were reported in Africa and Asia before 2007, but large outbreaks involving up to 73% of the populations on the Pacific islands have started since 2007, and spread to the Americas in 2014. Moreover, the clinical manifestation of ZIKV infection has apparently changed, as evident by increasing reports of neurological complications, such as Guillain-Barre syndrome in adults and congenital anomalies in neonates. We comprehensively compared the genome sequences of pre-epidemic and epidemic ZIKV strains with complete genome or complete polyprotein sequences available in GenBank. Besides the reported phylogenetic clustering of the epidemic strains with the Asian lineage, we found that the topology of phylogenetic tree of all coding regions is the same except that of the non-structural 2B (NS2B) coding region. This finding was confirmed by bootscan analysis and multiple sequence alignment, which suggested the presence of a fragment of genetic recombination at NS2B with that of Spondweni virus. Moreover, the representative epidemic strain possesses one large bulge of nine bases instead of an external loop on the first stem-loop structure at the 3'-untranslated region just distal to the stop codon of the NS5 in the 1947 pre-epidemic prototype strain. Fifteen amino acid substitutions are found in the epidemic strains when compared with the pre-epidemic strains. As mutations in other flaviviruses can be associated with changes in virulence, replication efficiency, antigenic epitopes and host tropism, further studies would be important to ascertain the biological significance of these genomic changes.",Pubmed,March 31, 2016,Yes,,No,"Zika, indirect evidence or other topic",Scientific (journal) article,Yes,Original research,No,Yes,486,Basic and applied biomedical research,Sequence analysis and phylogenetics
487,"McCarthy, BMJ, 2016",McCarthy,"McCarthy, M.",US health officials press Congress for Zika funds,BMJ,352,,i1545,2016,2010-present,March 17, 2016,26979935,10.1136/bmj.i1545,1127,English,,Seattle.,,,,,,,Pubmed,March 31, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",News item or lay press,,,No,Yes,487,,
488,"Villa, Clin Ter, 2016",Villa,"Villa, R.","Zika, or the burden of uncertainty",Clin Ter,167,1,07. Sep,2016,2010-present,March 17, 2016,26980631,10.7417/ct.2016.1907,1125,English,,"ASSET project, Zadig, Milano.",,,,,"Microcephaly, Public health, Risk communication, Zika virus","In the first phases of an infectious outbreak, health authorities have to face the challenge of communicating uncertainty. Just when the attention of the public is at the top, information about what is going on is usually still missing. This is the case of Zika crisis in Latin America, where an association with microcephaly in newborns and neurological complications have been described, but not yet confirmed. Despite this, and even if the risk would be mainly limited to pregnant women, Zika threat is perceived by the general public as greater than others, such as those from dengue or flu. Some peculiarities of this outbreak explain such a gap between real and perceived risk. Nevertheless, in such a situation, WHO and other health authorities have the duty to act out of an abundance of caution, aware of the lose-lose game they are going through: if they raise alarm, and this subsided, they could be accused to fuel people's fears because of economic interests, as it happened in 2009 A(H1N1) pandemic; if they underestimate the threat, they could find themselves in front of a global tragedy.",Pubmed,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,488,,
489,"Gudnason, Laeknabladid, 2016",Gudnason,"Gudnason, T.",[Zika virus - a relatively new human pathogen[Editorial]],Laeknabladid,102,3,115,2016,2010-present,March 18, 2016,26985587,10.17992/lbl.2016.03.67,1122,Other,,,,,,,,,Pubmed,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,489,,
490,"Rafiei, Med J Aust, 2016",Rafiei,"Rafiei, N.; Hajkowicz, K.; Redmond, A.; Taylor, C.",First report of Zika virus infection in a returned traveller from the Solomon Islands,Med J Aust,204,5,186,2016,2010-present,March 18, 2016,26985845,,1121,English,http://www.ncbi.nlm.nih.gov/pubmed/26985845,"Royal Brisbane and Women's Hospital, Brisbane, QLD nastaran.rafiei@uqconnect.edu.au.; Royal Brisbane and Women's Hospital, Brisbane, QLD.; Queensland Health Forensic and Scientific Services, Brisbane, QLD.",,,,,,,Pubmed,March 31, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Original research,No,Yes,490,Clinical/epidemiological research,Case report
491,"Cetron, MMWR Morb Mortal Wkly Rep, 2016",Cetron,"Cetron, M.","Revision to CDC's Zika Travel Notices: Minimal Likelihood for Mosquito-Borne Zika Virus Transmission at Elevations Above 2,000 Meters",MMWR Morb Mortal Wkly Rep,65,10,267-8,2016,2010-present,March 18, 2016,26985965,10.15585/mmwr.mm6510e1,1120,English,http://www.ncbi.nlm.nih.gov/pubmed/26985965,"Division of Global Migration and Quarantine, National Center for Emerging and Zoonotic Infectious Diseases, CDC.",,,,,,"Since May 2015, when Zika virus, a flavivirus transmitted primarily by Aedes aegypti mosquitoes, was reported in Brazil, the virus has rapidly spread across the Region of the Americas and the Caribbean. The association between maternal Zika virus infection and adverse fetal and reproductive outcomes, including microcephaly, prompted CDC to issue a Level 2 alert travel notice* for the 37 countries and U.S. territories (at the national and territorial level) that have reported recent Zika virus transmission as of March 11, 2016. In addition to mosquito bite precautions for all travelers, CDC advises that pregnant women postpone travel to affected countries and U.S. territories. Within a nation's borders, ecologic characteristics, which determine the distribution of mosquito vectors, can vary considerably. CDC conducted a spatial analysis, focusing on the probability of occurrence of Ae. aegypti, to support the demarcation for subnational travel alerts. Based on results of this analysis, travel that is limited to elevations higher than 2,000 m (6,562 ft) above sea level is considered to have minimal (approximately 1%) likelihood for mosquito-borne Zika virus transmission, even within countries reporting active transmission. Women who are pregnant should avoid travel to elevations <2,000 m in countries with active Zika virus transmission.",Pubmed,March 31, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,No,Other,No,Yes,491,,
492,"Lucey, Health Secur, 2016",Lucey,"Lucey, D. R.",Will Zika Virus and Microcephaly Epidemics Emerge After Ebola in West Africa? The Need for Prospective Studies Now,Health Secur,,,,2016,2010-present,March 18, 2016,26986702,10.1089/hs.2016.0033,1119,English,,"Daniel R. Lucey, MD, MPH, is adjunct professor of medicine at Georgetown University School of Medicine, Washington, DC, and a Senior Scholar at the O'Neill Institute for National and Global Health Law at Georgetown Law.",,,,,,,Pubmed,March 31, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,492,,
493,"Siqueira, Braz Oral Res, 2016",Siqueira,"Siqueira, W. L., Moffa, E. B., Mussi, M. C., Machado, M. A.",Zika virus infection spread through saliva - a truth or myth?,Braz Oral Res,30,1,e46,2016,2010-present,March 18, 2016,26981761,10.1590/1807-3107BOR-2016.vol30.0046,1124,English,,"Department of Dentistry and Biochemistry, Schulich School of Medicine & Dentistry, University of Western Ontario, London, ON, Canada., Department of Oral Pathology, School of Dentistry, Universidade de Sao Paulo, Sao Paulo, SP, Brazil., Department of Pediatric Dentistry, Orthodontics and Public Health, Bauru Dental School, Universidade de Sao Paulo, Bauru, SP, Brazil.",,,,,,"In this Point-of-view article we highlighted some features related to saliva and virus infection, in special for zika virus. In addition, we pointed out the potential oral problems caused by a microcephaly originated by a zika virus infection. In the end the, we demonstrated the importance of a more comprehensive exploration of saliva and their components as a fluid for diagnostic and therapeutic approaches on oral and systemic diseases.",Pubmed,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,493,,
494,"Venturi, Eurosurveillance, 2016",Venturi,"Venturi, G.; Zammarchi, L.; Fortuna, C.; Remoli, M. E.; Benedetti, E.; Fiorentini, C.; Trotta, M.; Rizzo, C.; Mantella, A.; Rezza, G.; Bartoloni, A.",Authors' reply: diagnostic challenges to be considered regarding Zika virus in the context of the presence of the vector Aedes albopictus in Europe,Eurosurveillance,21,10,,2016,2010-present,March 19, 2016,26988337,10.2807/1560-7917.ES.2016.21.10.30163,1115,English,http://www.ncbi.nlm.nih.gov/pubmed/26988337,"Department of Infectious, Parasitic and Immune-Mediate Diseases, Istituto Superiore di Sanita, Rome, Italy.",,,,,Europe; Italy; Pnrt; Zika; arboviruses,,Pubmed,March 31, 2016,Yes,,No,"Zika, not relevant to causality framework",Scientific (journal) article,Yes,Other,Yes,No,205,,
495,"Malkki, Nat Rev Neurol, 2016",Malkki,"Malkki, H.",CNS infections: Zika virus infection could trigger Guillain-Barre syndrome,Nat Rev Neurol,12,4,187,2016,2010-present,March 19, 2016,26988905,10.1038/nrneurol.2016.30,1114,English,http://www.ncbi.nlm.nih.gov/pubmed/26988905,,,,,,,,Pubmed,March 31, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,No,Comment/Editorial/Perspective/Letter,No,Yes,495,,
496,"Vasconcelos, Vector Borne Zoonotic Dis, 2016",Vasconcelos,"Vasconcelos, P. F.; Calisher, C. H.","Emergence of Human Arboviral Diseases in the Americas, 2000-2016",Vector Borne Zoonotic Dis,,,,2016,2010-present,March 19, 2016,26991057,10.1089/vbz.2016.1952,1113,English,http://www.ncbi.nlm.nih.gov/pubmed/26991057,"1 Department of Arbovirology and Hemorrhagic Fevers, Evandro Chagas Institute , Brazilian Ministry of Health, Ananindeua, Para, Brazil .; 2 Department of Pathology, University of Para State , Belem, Brazil .; 3 Arthropod-Borne and Infectious Diseases Laboratory, Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University , Fort Collins, Colorado.",,,,,Arbovirus; Bourbon; Cache Valley; Chikungunya; Emerging; Heartland; Iquitos; Mayaro; Powassan; The Americas; Zika; Zoonoses,"In addition to individual or clusters of cases of human infections with arboviruses, the past 15 years has seen the emergence of newly recognized arboviruses and the re-emergence of others. Mentioned in this brief summary are Bourbon, Cache Valley, chikungunya, Heartland, Itaqui, Mayaro, Oropouche, Powassan, and Zika viruses, the latter being a remarkable occurrence.",Pubmed,March 31, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Review,No,Yes,496,Clinical/epidemiological research,Epidemiological/clinical review
497,"Carod-Artal, Rev Neurol, 2016",Carod-Artal,"Carod-Artal, F. J.",Epidemiology and neurological complications of infection by the Zika virus: a new emerging neurotropic virus,Rev Neurol,62,7,317-328,2016,2010-present,March 19, 2016,26988170,,1116,English,http://www.ncbi.nlm.nih.gov/pubmed/26988170,"Raigmore Hospital, Inverness, Reino Unido.",,,,,,"INTRODUCTION: The current epidemic outbreak due to Zika virus began in 2015 and since then it has been reported in 31 countries and territories in America. The epidemiological and clinical aspects related to infection by Zika virus are reviewed. DEVELOPMENT: Since 2007, 55 countries in America, Asia, Africa and Oceania have detected local transmission of the virus. This epidemic has affected almost 1.5 million people in Brazil. 80% of the cases are asymptomatic. The symptoms of Zika virus disease include fever, maculopapular rash, arthralgia and non-purulent conjunctivitis. The symptoms are usually self-limiting and last one week. An increase in the incidence of cases of microcephaly, retinal lesions and Guillain-Barre syndrome associated with the Zika virus has been reported. Zika-associated Guillain-Barre syndrome in Polynesia is a pure motor axonal variant. The RNA of the Zika virus has been identified in samples of brain tissue, placenta and amniotic liquid of children with microcephaly and in the still-born infants of women infected by Zika during pregnancy. The reverse transcription polymerase chain reaction test is recommended to detect viral RNA, and serological tests (IgM ELISA and neutralising antibodies) should be conducted to confirm infection by Zika. The differential diagnosis includes infection by the dengue and chikungunya viruses. CONCLUSIONS: Knowledge about the pathogenic mechanisms involved in infection due to Zika virus and its long-term consequences in adults and newborn infants is still limited.; Publisher: Abstract available from the publisher.; Spa",Pubmed,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Yes,Review,No,Yes,497,Clinical/epidemiological research,Epidemiological/clinical review
498,"Barzon, Eurosurveillance, 2016",Barzon,"Barzon, L.; Pacenti, M.; Berto, A.; Sinigaglia, A.; Franchin, E.; Lavezzo, E.; Brugnaro, P.; Palu, G.","Isolation of infectious Zika virus from saliva and prolonged viral RNA shedding in a traveller returning from the Dominican Republic to Italy, January 2016",Eurosurveillance,21,10,,2016,2010-present,March 19, 2016,26987769,10.2807/1560-7917.ES.2016.21.10.30159,1118,English,http://www.ncbi.nlm.nih.gov/pubmed/26987769,"Department of Molecular Medicine, University of Padova, Padova, Italy.",,,,,Zika virus; diagnosis; genome sequencing; saliva; transmission; virus isolation,"We report the isolation of infectious Zika virus (ZIKV) in cell culture from the saliva of a patient who developed a febrile illness after returning from the Dominican Republic to Italy, in January 2016. The patient had prolonged shedding of viral RNA in saliva and urine, at higher load than in blood, for up to 29 days after symptom onset. Sequencing of ZIKV genome showed relatedness with strains from Latin America.",Pubmed,March 31, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Original research,No,Yes,498,Clinical/epidemiological research,Case report
499,"Vorou, Eurosurveillance, 2016",Vorou,"Vorou, R.",Letter to the editor: diagnostic challenges to be considered regarding Zika virus in the context of the presence of the vector Aedes albopictus in Europe,Eurosurveillance,21,10,,2016,2010-present,March 19, 2016,26988027,10.2807/1560-7917.ES.2016.21.10.30161,1117,English,http://www.ncbi.nlm.nih.gov/pubmed/26988027,"Unit for Strategic Development and Policy, Hellenic Center for Diseases Control and Prevention, Athens, Greece.",,,,,Europe Aedes albopictus; Zika in Europe; Zika virus diagnosis; Zika virus infection,,Pubmed,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,Yes,No,205,,
500,"Russell, PLoS Negl Trop Dis, 2016",Russell,"Russell, P. K.",The Zika Pandemic - A Perfect Storm?,PLoS Negl Trop Dis,10,3,e0004589,2016,2010-present,March 19, 2016,26991663,10.1371/journal.pntd.0004589,1112,English,,"Sabin Vaccine Institute, Washington, D.C., United States of America.",,,,,,,Pubmed,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,500,,
501,"Cauchemez, Lancet, 2016",Cauchemez,"Cauchemez, S.; Besnard, M.; Bompard, P.; Dub, T.; Guillemette-Artur, P.; Eyrolle-Guignot, D.; Salje, H.; Van Kerkhove, M. D.; Abadie, V.; Garel, C.; Fontanet, A.; Mallet, H. P.","Association between Zika virus and microcephaly in French Polynesia, 2013-15: a retrospective study",Lancet,,,,2016,2010-present,March 20, 2016,26993883,10.1016/S0140-6736(16)00651-6,1107,English,http://www.ncbi.nlm.nih.gov/pubmed/26993883,"Mathematical Modelling of Infectious Diseases, Institut Pasteur, Paris, France. Electronic address: simon.cauchemez@pasteur.fr.; Neonatal Care Department, French Polynesia Hospital Centre, Pirae, Tahiti, French Polynesia.; Bureau de Veille Sanitaire, Direction de la Sante, Papeete, Tahiti, French Polynesia.; Emerging Diseases Epidemiology Unit, Institut Pasteur, Paris, France.; Medical Imaging Department, French Polynesia Hospital Centre, Pirae, Tahiti, French Polynesia.; Gynecology-Obstetrics Department, French Polynesia Hospital Centre, Pirae, Tahiti, French Polynesia.; Mathematical Modelling of Infectious Diseases, Institut Pasteur, Paris, France; Department of Epidemiology, Johns Hopkins University, Baltimore, MD, USA.; Centre for Global Health, Institut Pasteur, Paris, France.; General Paediatrics Department, Necker Hospital, Paris, France.; Department of Paediatric Radiology, Hopital d'Enfants Armand-Trousseau, Paris, France.; Emerging Diseases Epidemiology Unit, Institut Pasteur, Paris, France; Centre for Global Health, Institut Pasteur, Paris, France; Conservatoire National des Arts et Metiers, Paris, France.",France,Europe,French Polynesia,Mixed,,"BACKGROUND: The emergence of Zika virus in the Americas has coincided with increased reports of babies born with microcephaly. On Feb 1, 2016, WHO declared the suspected link between Zika virus and microcephaly to be a Public Health Emergency of International Concern. This association, however, has not been precisely quantified. METHODS: We retrospectively analysed data from a Zika virus outbreak in French Polynesia, which was the largest documented outbreak before that in the Americas. We used serological and surveillance data to estimate the probability of infection with Zika virus for each week of the epidemic and searched medical records to identify all cases of microcephaly from September, 2013, to July, 2015. Simple models were used to assess periods of risk in pregnancy when Zika virus might increase the risk of microcephaly and estimate the associated risk. FINDINGS: The Zika virus outbreak began in October, 2013, and ended in April, 2014, and 66% (95% CI 62-70) of the general population were infected. Of the eight microcephaly cases identified during the 23-month study period, seven (88%) occurred in the 4-month period March 1 to July 10, 2014. The timing of these cases was best explained by a period of risk in the first trimester of pregnancy. In this model, the baseline prevalence of microcephaly was two cases (95% CI 0-8) per 10 000 neonates, and the risk of microcephaly associated with Zika virus infection was 95 cases (34-191) per 10 000 women infected in the first trimester. We could not rule out an increased risk of microcephaly from infection in other trimesters, but models that excluded the first trimester were not supported by the data. INTERPRETATION: Our findings provide a quantitative estimate of the risk of microcephaly in fetuses and neonates whose mothers are infected with Zika virus. FUNDING: Labex-IBEID, NIH-MIDAS, AXA Research fund, EU-PREDEMICS.",Pubmed,March 31, 2016,Yes,,Yes,,Scientific (journal) article,Yes,Original research,No,Yes,501,Clinical/epidemiological research,Modelling study
502,"Deng, Sci China Life Sci, 2016",Deng,"Deng, Y. Q.; Zhao, H.; Li, X. F.; Zhang, N. N.; Liu, Z. Y.; Jiang, T.; Gu, D. Y.; Shi, L.; He, J. A.; Wang, H. J.; Sun, Z. Z.; Ye, Q.; Xie, D. Y.; Cao, W. C.; Qin, C. F.","Isolation, identification and genomic characterization of the Asian lineage Zika virus imported to China",Sci China Life Sci,,,,2016,2010-present,March 20, 2016,26993654,10.1007/s11427-016-5043-4,1109,English,http://www.ncbi.nlm.nih.gov/pubmed/26993654,"Department of Virology, State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, 100071, China.; Graduate School, Guangxi Medical University, Xining, 530021, China.; The Central Laboratory of Health Quarantine, Shenzhen Travel Healthcare Center, Shenzhen Entry-Exit Inspection and Quarantine Bureau, Shenzhen, 518033, China.; Laboratory Animal Center, Academy of Military Medical Science, Beijing, 100071, China.; Graduate School, Anhui Medical University, Hefei, 230032, China.; Department of Virology, State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, 100071, China. caowc@bmi.ac.cn.; Department of Virology, State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, 100071, China. qincf@bmi.ac.cn.; Graduate School, Guangxi Medical University, Xining, 530021, China. qincf@bmi.ac.cn.; Graduate School, Anhui Medical University, Hefei, 230032, China. qincf@bmi.ac.cn.",China,Asia,China,,,,Pubmed,March 31, 2016,Yes,,Yes,,Scientific (journal) article,Yes,Original research,No,Yes,502,Basic and applied biomedical research,Animal experiment
503,"Rodrigues, Lancet, 2016",Rodrigues,"Rodrigues, L. C.",Microcephaly and Zika virus infection,Lancet,,,,2016,2010-present,March 20, 2016,26993880,10.1016/S0140-6736(16)00742-X,1108,English,http://www.ncbi.nlm.nih.gov/pubmed/26993880,"London School of Hygiene & Tropical Medicine, London WC1E 7HT, UK; Microcephaly Epidemic Research Group (MERG), Recife, Brazil. Electronic address: laura.rodrigues@lshtm.ac.uk.",,,,,,"Rarely have scientists engaged with a new research agenda with such a sense of urgency and from such a small knowledge base as in the current epidemic of microcephaly (6000 notified suspected cases in Brazil1 and the first case detected in Colombia in March, 20162) associated with the Zika virus outbreak across the Americas. Indeed, in 2015, in a review of infections that have neurological consequences, Zika virus was not even mentioned.3 In only 5 months since the detection of the first excess cases of microcephaly in Brazil,4 WHO has declared the clusters of microcephaly and other neurological disorders to be a Public Health Emergency of International Concern.",Pubmed,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,503,,
504,"Molloy, Appl Environ Microbiol, 2016",Molloy,"Molloy, J. C., Sommer, U., Viant, M. R., Sinkins, S. P.",Wolbachia modulates lipid metabolism in Aedes albopictus mosquito cells,Appl Environ Microbiol,,,,2016,2010-present,March 20, 2016,26994075,10.1128/aem.00275-16,1106,English,,"University of Oxford, Peter Medawar Building for Pathogen Research & Nuffield Department of Medicine/Department of Zoology, Oxford OX1 3SY., NERC Biomolecular Analysis Facility - Metabolomics Node (NBAF-B), School of Biosciences, University of Birmingham, Birmingham, B15 2TT., University of Oxford, Peter Medawar Building for Pathogen Research & Nuffield Department of Medicine/Department of Zoology, Oxford OX1 3SY. Lancaster University, Biomedical and Life Sciences, Lancaster LA1 4YQ s.sinkins@lanccaster.ac.uk.",,,,,,"Certain strains of the intracellular endosymbiont Wolbachia can strongly inhibit or block the transmission of viruses such as dengue (DENV) by Aedes mosquitoes, and the mechanisms responsible are still not well understood. Direct infusion and liquid chromatography FT-ICR mass spectrometry based lipidomics analyses were conducted using Aedes albopictus Aa23 cells that were infected with the wMel and wMelPop strains of Wolbachia compared to uninfected Aa23-T cells. Substantial shifts in the cellular lipid profile were apparent in the presence of Wolbachia. Most significantly, almost all sphingolipid classes were depleted, and some reductions in diacylglycerols and phosphatidylcholines were also observed. These lipid classes have previously been shown to be selectively enriched in DENV-infected mosquito cells, suggesting that Wolbachia may produce a cellular lipid environment that is antagonistic to viral replication. The data improve our understanding of the intracellular interactions between Wolbachia and mosquitoes. IMPORTANCE: Mosquitoes transmit a variety of important viruses to humans, such as dengue and zika. Certain strains of intracellular bacteria called Wolbachia found or introduced into mosquitoes can block the transmission of viruses, including dengue, but the mechanisms responsible are not well understood. We found substantial shifts in the cellular lipid profiles in the presence of these bacteria. Some lipid classes previously been shown to be enriched in dengue-infected mosquito cells were depleted in the presence of Wolbachia, suggesting that Wolbachia may produce a cellular lipid environment that inhibits mosquito-borne viruses.",Pubmed,March 31, 2016,No,Unrelated to Zika virus,,,Scientific (journal) article,Yes,Original research,No,Yes,504,Environmental and vector research,Vector control studies
505,"Martinez de Salazar, Enferm Infecc Microbiol Clin, 2016",Martinez de Salazar,"Martinez de Salazar, P., Suy, A., Sanchez-Montalva, A., Rodo, C., Salvador, F., Molina, I.",Zika fever,Enferm Infecc Microbiol Clin,,,,2016,2010-present,March 20, 2016,26993436,10.1016/j.eimc.2016.02.016,1110,English,,"Microbiology Department, Vall d'Hebron University Hospital, PROSICS Barcelona, Spain; IS Global and the Barcelona Centre for International Health Research (CRESIB), Barcelona, Spain. Electronic address: pmartinezdesalazar@gmail.com., Obstetrics and Gynaecology Department, Maternal fetal Medicine Unit, Vall d'Hebron University Hospital, Spain., Infectious Diseases Department, Vall d'Hebron University Hospital, PROSICS Barcelona, Spain.",,,,,"Flavivirus, Microcefalia, Microencephaly, Virus Zika, Zika virus","Zika fever is an arboviral systemic disease that has recently become a public health challenge of global concern after its spread through the Americas. This review highlights the current understanding on Zika virus epidemiology, its routes of transmission, clinical manifestations, diagnostic tests, and the current management, prevention and control strategies. It also delves the association between zika infection and complications, such as microencephaly or Guillem-Barre syndrome.",Pubmed,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Yes,Review,No,Yes,505,Clinical/epidemiological research,Epidemiological/clinical review
506,"Zanluca, Microbes Infect, 2016",Zanluca,"Zanluca, C.; Dos Santos, C. N.",Zika virus - An overview,Microbes Infect,,,,2016,2010-present,March 20, 2016,26993028,10.1016/j.micinf.2016.03.003,1111,English,http://www.ncbi.nlm.nih.gov/pubmed/26993028,"Laboratorio de Virologia Molecular, Instituto Carlos Chagas, Fundacao Oswaldo Cruz, Curitiba, PR, Brazil.; Laboratorio de Virologia Molecular, Instituto Carlos Chagas, Fundacao Oswaldo Cruz, Curitiba, PR, Brazil. Electronic address: clsantos@fiocruz.br.",,,,,Arthropod-borne virus; Flavivirus; Viral emergence; Zika virus,"Zika virus (ZIKV) is currently one of the most important emerging viruses in the world. Recently, it has caused outbreaks and epidemics, and has been associated with severe clinical manifestations and congenital malformations. However to date, little is known about the pathogenicity of the virus and the consequences of ZIKV infection. In this paper, we provide an overview of the current knowledge on ZIKV.",Pubmed,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Yes,Review,No,Yes,506,Clinical/epidemiological research,Epidemiological/clinical review
507,"Bachiller-Luque, Enferm Infecc Microbiol Clin, 2016",Bachiller-Luque,"Bachiller-Luque, P.; Dominguez-Gil Gonzalez, M.; Alvarez-Manzanares, J.; Vazquez, A.; De Ory, F.; Sanchez-Seco Farinas, M. P.",First case of imported Zika virus infection in Spain,Enferm Infecc Microbiol Clin,,,,2016,2010-present,March 21, 2016,26994814,10.1016/j.eimc.2016.02.012,1104,English,http://www.ncbi.nlm.nih.gov/pubmed/26994814,"Internal Medicine, University Hospital Rio Hortega, Valladolid, Spain. Electronic address: pbachiller@gmail.com.; Microbiology, University Hospital Rio Hortega, Valladolid, Spain.; Emergency, University Hospital Rio Hortega, Valladolid, Spain.; Virology Area (Arbovirus and Imported Viral Diseases), National Center for Microbiology, Institute Carlos III, Majadahonda, Madrid, Spain.",,,,,Aedes mosquitoes; Arbovirus; Enfermedades transmitidas por vectores; Flavivirus; Mosquitos Aedes; Vector-borne diseases; Virus Zika; Zika virus,"We report a case of Zika virus (ZIKV) infection in a patient with diarrhea, fever, synovitis, non-purulent conjunctivitis, and with discreet retro-orbital pain, after returning from Colombia in January 2016. The patient referred several mosquito bites. Presence of ZIKV was detected by PCR (polymerase chain reaction) in plasma. Rapid microbiological diagnosis of ZIKV infection is needed in European countries with circulation of its vector, in order to avoid autochthonous circulation. The recent association of ZIKV infection with abortion and microcephaly, and a Guillain-Barre syndrome highlights the need for laboratory differentiation of ZIKV from other virus infection. Women with potential risk for Zika virus infection who are pregnant or planning to become pregnant must mention that fact during prenatal visits in order to be evaluated and properly monitored.",Pubmed,March 31, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Original research,No,Yes,507,Clinical/epidemiological research,Case report
508,"Shuaib, Am J Med, 2016",Shuaib,"Shuaib, W., Stanazai, H., Abazid, A. G., Mattar, A. A.","The reemergence of Zika virus: a review on pathogenesis, clinical manifestations, diagnosis, and treatment",Am J Med,,,,2016,2010-present,March 21, 2016,26994509,10.1016/j.amjmed.2016.02.027,1105,English,,"Department of Medicine, Auburn Community Hospital, Auburn, NY. Electronic address: Waqas1184@hotmail.com., Wichita Falls Family Practice Residency Program, Wichita Falls, TX.",,,,,"Brazil, Chikungunya, Dengue, Microcephaly, Zika","Zika virus (ZKV) is an arbovirus of the Flaviviridae family, which includes West Nile, Dengue Fever, Chikungunya Virus, Yellow Fever, and Japanese encephalitis virus. It is transmitted by the Aedes genus of mosquitoes. Prior to 2015, ZKV outbreaks occurred in areas of Africa, the Pacific Islands and Southeast Asia. The current large outbreak, which began in Brazil, has also emerged throughout a large part of South/Central America, a number of islands in the Caribbean, including Puerto Rico, the Virgin Islands, and Mexico. A sudden rise in the numbers of infants reported born with microcephaly in Brazil, and the detection of the single-stranded positive RNA virus in the amniotic fluid of affected newborns, has captured medical, mainstream media, and global political attention, causing considerable concern in a post-Ebola global community considerably more focused on the threat of internationally transmissible diseases. The goal of this article is to provide an overview of ZKV for clinicians, with the emphasis on pathogenesis, clinical manifestations, diagnosis, and treatment/preventive measures.",Pubmed,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Yes,Review,No,Yes,508,Clinical/epidemiological research,Epidemiological/clinical review
509,"Gardner, Lancet Infect Dis, 2016",Gardner,"Gardner, L. M.; Chen, N.; Sarkar, S.",Global risk of Zika virus depends critically on vector status of Aedes albopictus,Lancet Infect Dis,,,,2016,2010-present,March 22, 2016,26997578,10.1016/S1473-3099(16)00176-6,1102,English,http://www.ncbi.nlm.nih.gov/pubmed/26997578,"University of New South Wales Australia, Sydney, NSW, Australia. Electronic address: l.gardner@unsw.edu.au.; University of New South Wales Australia, Sydney, NSW, Australia.; Department of Integrative Biology, University of Texas, Austin, TX, USA.",,,,,,"Constância F J Ayres1 recently pointed out that Zika virus has been collected from several mosquito species including those from the genera, Anopheles, Culex, and Mansonia besides Aedes. Moreover, at least ten Aedes species are known to harbour Zika virus. However, the presence of the virus does not automatically make the species an efficient vector for the disease. It is, therefore, unfortunate that a recent risk map published in The Lancet considers Aedes aegypti and Aedes albopictus together.",Pubmed,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,509,,
510,"Ladhani, Arch Dis Child, 2016",Ladhani,"Ladhani, S. N., O'Connor, C., Kirkbride, H., Brooks, T., Morgan, D.","Outbreak of Zika virus disease in the Americas and the association with microcephaly, congenital malformations and Guillain-Barre syndrome",Arch Dis Child,,,,2016,2010-present,March 22, 2016,26998633,10.1136/archdischild-2016-310590,1101,English,,"National Infection Service, Public Health England, London, UK Paediatric Infectious Diseases Research Group, St. George's University of London, London, UK., National Infection Service, Public Health England, London, UK., Rare and Imported Pathogens Laboratory, Public Health England, Salisbury, UK.",,,,,"Brazil, Guillain-Barre syndrome, Zika virus, microcephaly, trave",,Pubmed,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Yes,Review,No,Yes,510,Clinical/epidemiological research,Epidemiological/clinical review
511,"Weaver, Antiviral Res, 2016",Weaver,"Weaver, S. C., Costa, F., Garcia-Blanco, M. A., Ko, A. I., Ribeiro, G. S., Saade, G., Shi, P. Y., Vasilakis, N.","Zika Virus: History, Emergence, Biology, and Prospects for Control",Antiviral Res,,,,2016,2010-present,March 22, 2016,26996139,10.1016/j.antiviral.2016.03.010,1103,English,,"Instituqmmunity, and Departments of Microbiology & Immunology and Pathology, University of Texas Medical Branch, Galveston TX, USA. Electronic address: sweaver@utmb.edu., Centro de Pesquisas Goncalo Moniz, Fundacao Oswaldo Cruz, Ministerio da Saude, Salvador BA, Brazil; Instituto da Saude Coletiva, Universidade Federal da Bahia, Salvador BA, Brazil., Department of Biochemistry & Molecular Biology, University of Texas Medical Branch, Galveston, TX, USA; Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore., Centro de Pesquisas Goncalo Moniz, Fundacao Oswaldo Cruz, Ministerio da Saude, Salvador BA, Brazil; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, USA., Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, TX, USA., Departments of Biochemistry & Molecular Biology and Pharmacology & Toxicology, and Sealy Center for Structural Biology & Molecular Biophysics, University of Texas Medical Branch, Galveston, TX, USA., Instituqmmunity, and Departments of Microbiology & Immunology and Pathology, University of Texas Medical Branch, Galveston TX, USA.",,,,,,"Zika virus (ZIKV), a previously obscure flavivirus closely related to dengue, West Nile, Japanese encephalitis and yellow fever viruses, has emerged explosively since 2007 to cause a series of epidemics in Micronesia, the South Pacific, and most recently the Americas. After its putative evolution in sub-Saharan Africa, ZIKV spread in the distant past to Asia and has probably emerged on multiple occasions into urban transmission cycles involving Aedes (Stegomyia) spp. mosquitoes and human amplification hosts, accompanied by a relatively mild dengue-like illness. The unprecedented numbers of people infected during recent outbreaks in the South Pacific and the Americas may have resulted in enough ZIKV infections to notice relatively rare congenital microcephaly and Guillain-Barre syndromes. Another hypothesis is that phenotypic changes in Asian lineage ZIKV strains led to these disease outcomes. Here, we review potential strategies to control the ongoing outbreak through vector-centric approaches as well as the prospects for the development of vaccines and therapeutics.",Pubmed,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Yes,Review,No,Yes,511,Clinical/epidemiological research,Epidemiological/clinical review
512,"Li, Zhonghua Liu Xing Bing Xue Za Zhi, 2016",Li,"Li, J. D.; Li, D. X.",[Epidemiological characteristics of Zika virus disease],Zhonghua Liu Xing Bing Xue Za Zhi,37,3,329-34,2016,2010-present,March 24, 2016,27005530,10.3760/cma.j.issn.0254-6450.2016.03.007,1093,Other,http://www.ncbi.nlm.nih.gov/pubmed/27005530,"Department of Viral Hemorrhagic Fever, Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.",,,,,,"Zika virus disease is an emerging mosquito-borne acute infectious disease caused by Zika virus, so far there have been no available vaccine or specific treatment. Currently, the outbreaks of Zika virus disease mainly occurs in the Americas, but the regional distribution of the disease is in rapid expansion, 34 countries and territories have reported autochthonous transmission of the virus. The illness is usually mild with very rarely death, but increased reports of birth defects and neurologic disorders in the areas affected by Zika virus has caused extensive concern worldwide. In China, the competent vectors for Zika virus are widely distributed, imported viraemic cases may become a source of local transmission of the virus. However, Zika virus disease is preventable, the spread of virus could be stopped when the effective prevention measures are taken. This paper summarizes the retrieval results from Medline database and the information from the reports of the governments of countries affected or health organizations about the epidemiological characteristics of Zika virus disease.",Pubmed,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Unknown/unclear,Review,No,Yes,512,Clinical/epidemiological research,Epidemiological/clinical review
513,"Freitas, Rev Inst Med Trop Sao Paulo, 2016",Freitas,"Freitas, A. R.; Angerami, R. N.; Zuben, A. P.; Donalisio, M. R.",Introduction and Transmission of Zika Virus in Brazil: New Challenges for the Americas,Rev Inst Med Trop Sao Paulo,58,,e24,2016,2010-present,March 24, 2016,27007567,10.1590/S1678-9946201658024,1090,English,http://www.ncbi.nlm.nih.gov/pubmed/27007567,"Departamento de Medicina Social, Faculdade de Medicina Sao Leopoldo Mandic, Campinas, SP, Brasil, arrfreitas2010@gmail.com.; Hospital das Clinicas, Departamento de Infectologia, Universidade Estadual de Campinas, Campinas, SP, Brasil, rodrigo.angerami@gmail.com.; Departamento de Vigilancia a Saude, Campinas, SP, Brasil, andreabrunovonzuben@gmail.com.; Departamento de Saude Coletiva, Faculdade de Ciencias Medicas, Universidade Estadual de Campinas, Campinas, SP, Brasil, rita.donalisio@gmail.com.",,,,,,,Pubmed,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,513,,
514,"Gandhi, Neotrop Entomol, 2016",Gandhi,"Gandhi, M. R.; Reegan, A. D.; Ganesan, P.; Sivasankaran, K.; Paulraj, M. G.; Balakrishna, K.; Ignacimuthu, S.; Al-Dhabi, N. A.",Larvicidal and Pupicidal Activities of Alizarin Isolated from Roots of Rubia cordifolia Against Culex quinquefasciatus Say and Aedes aegypti (L.) (Diptera: Culicidae),Neotrop Entomol,,,,2016,2010-present,March 24, 2016,27004695,10.1007/s13744-016-0386-x,1095,English,http://www.ncbi.nlm.nih.gov/pubmed/27004695,"Division of Vector Control, Entomology Research Institute, Loyola College, Nungambakkam, Chennai, 600 034, Tamil Nadu, India.; Division of Vector Control, Entomology Research Institute, Loyola College, Nungambakkam, Chennai, 600 034, Tamil Nadu, India. eriloyola@hotmail.com.; Visiting Professor Programme, Deanship of Research, King Saud Univ, Riyadh, Saudi Arabia. eriloyola@hotmail.com.; Dept of Botany and Microbiology, Addiriyah chair for Environmental Studies, College of Science, King Saud Univ, Riyadh, Saudi Arabia.",,,,,Bioassay; Zika virus; chikungunya; dengue; lymphatic filariasis; mosquito control; sustainable pest control; vector control,"The mosquitocidal activities of different fractions and a compound alizarin from the methanol extract of Rubia cordifolia roots were evaluated on larvae and pupae of Culex quinquefasciatus Say and Aedes aegypti (L.) (Diptera: Culicidae). Larvae and pupae were exposed to concentrations of 2.5, 5.0, 7.5 and 10 ppm for fractions and 0.5, 1.0, 1.5 and 2.0 ppm for compound. After 24 h, the mortality was assessed and the LC50 and LC90 values were estimated for larvae and pupae. Among the 23 fractions screened, fraction 2 from the methanol extract of R. cordifolia showed good mosquitocidal activity against C. quinquefasciatus and A. aegypti. LC50 and LC90 values of fraction 2 were 3.53 and 7.26 ppm for C. quinquefasciatus and 3.86 and 8.28 ppm for A. aegypti larvae, and 3.76 and 7.50 ppm for C. quinquefasciatus and 3.92 and 8.05 ppm for A. aegypti pupae, respectively. Further, the isolated compound alizarin presented good larvicidal and pupicidal activities. LC50 and LC90 values of alizarin for larvae were 0.81 and 3.86 ppm against C. quinquefasciatus and 1.31 and 6.04 ppm for A. aegypti larvae, respectively. Similarly, the LC50 and LC90 values of alizarin for pupae were 1.97 and 4.79 ppm for C. quinquefasciatus and 2.05 and 5.59 ppm for A. aegypti pupae, respectively. The structure of the isolated compound was identified on the basis of spectroscopic analysis and compared with reported spectral data. The results indicated that alizarin could be used as a potential larvicide and pupicide.",Pubmed,March 31, 2016,No,Unrelated to Zika virus,,,Scientific (journal) article,Yes,Original research,No,Yes,514,Environmental and vector research,Vector control studies
515,"Shakir, J Neurol Sci, 2016",Shakir,"Shakir, R.",Neurologists and Zika,J Neurol Sci,363,,164,2016,2010-present,March 24, 2016,27000244,10.1016/j.jns.2016.02.045,1099,English,http://www.ncbi.nlm.nih.gov/pubmed/27000244,"Imperial College, London, Charing Cross Hospital, London W6 8RF, London United Kingdom; President World Federation of Neurology. Electronic address: r.shakir@imperial.ac.uk.",,,,,,"The world is facing another viral epidemic, which is causing major concerns. Zika Flavi virus is transmitted by Aedes mosquitos and is now prevalent in the northern regions of South America and Central America. The WHO on the 1st February 2016 has declared Zika as Public Health Emergency of International Concern PHEIC [1]. The illness itself is mild and by and large does not need major medical intervention. However, the neurological consequences are devastating. This was the reason why the WHO has acted expeditiously [2]. Microcephaly, which has already affected thousands of babies is a major burden and will lead to lifelong major disability. Now that a post mortem case following termination of such an affected fetus has demonstrated Zika virus material in the brain [3] we are probably clearer on the association. Long-term disabilities with convulsions associated with severe psychomotor retardation are the expected consequences. These children will need lifelong neurological care.    The other issue, which has been reported in many countries, is the noticeably increased number of those affected by Guillain-Barre syndrome (GBS). In a way, it is expected that this will happen following a viral illness although the association with a related flavi viruses such as Dengue is not conclusive. We do not know the type or severity of the GBS, but we know that in the absence of supportive treatment the mortality will be more than the generally expected 5% of affected individuals. So far we do not know the real number of those affected. If we presume that the preceding infection with Zika is similar to Campylobacter jejuni where 1:1000-5000 maybe affected [4] we are going to be faced by tens of thousands of cases. Moreover, we do not know if some of those infected by Zika without showing symptoms (80%), can go on to develop GBS. We also do not know if antecedent Zika infection will produce different clinical manifestations of GBS similar to the different varieties seen following triggers such as C. jejuni, CMV, EBV or others?    It is conceivable that other neurological deficits can result form Zika infection. As the virus is isolated from brain and spinal cord of an unborn fetus [3] it may prove able invade directly other parts of the nervous system in an immediate or latent manner. Neurologists have to be vigilant in affected areas [5].    Neurological expertise is therefore crucial to deal with Zika sequelae, both for babies with seizures and developmental delay and for GBS. In the latter, neurological care is needed at the outset to make a correct diagnosis, if one is going to proceed to use expensive treatments such as intravenous immunoglobulins (IV Ig) or plasma exchange [6] and [7]. In the UK the Department of Health places the highest priority on the use IV IG in GBS, because of risk to life without treatment [8] and [9] In many affected areas there is a huge shortage of neurologists, lack of neurophysiological investigations, very scarce intensive care facilities to cope with the 25% of GBS patients with respiratory muscle involvement who may require assisted ventilation [4] In addition to lack of funding for provision of Immunoglobulins or plasma exchange. With all this background, the WHO Zika fact sheet fails to mention the need for neurological expertise to deal with those affected by Zika [10].    The question is what to do in the face of these difficulties many of which are really insurmountable at short notice? The only plausible but maybe a difficult action is for governments, the WHO, UN or other aid agencies to coordinate the provision of Intravenous immunoglobulin to be dispensed to those who have a clear clinical diagnosis of GBS. Neurologists in the affected areas are mainly centered in major cities and if we are going to try to avoid inappropriate and wasteful usage yet keep mortality down, then guidelines for general practitioners/family physicians have to be urgently produced on case ascertainment and dispensing IV Ig appropriately. Otherwise there shall be many unnecessary deaths, which would not happen if those affected were living in a less deprived part of the world. There is no time to waste and the neurological community will need to act now. (all not just abstract)",Pubmed,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,515,,
516,"Cardona-Cardona, J Infect Public Health, 2016",Cardona-Cardona,"Cardona-Cardona, A. F., Rodriguez Morales, A. J.","Severe abdominal pain in a patient with Zika infection: A case in Risaralda, Colombia",J Infect Public Health,,,,2016,2010-present,March 24, 2016,27005012,10.1016/j.jiph.2016.03.001,1094,English,,"Hospital Cristo Rey, Balboa, Risaralda, Colombia; Grupo de Investigacion Salud Publica e Infeccion, Facultad de Ciencias de la Salud, Universidad Tecnologica de Pereira, Pereira, Risaralda, Colombia., Grupo de Investigacion Salud Publica e Infeccion, Facultad de Ciencias de la Salud, Universidad Tecnologica de Pereira, Pereira, Risaralda, Colombia; Organizacion Latinoamericana para el Fomento de la Investigacion en Salud, Bucaramanga, Santander, Colombia. Electronic address: arodriguezm@utp.edu.co.",,,,,,,Pubmed,March 31, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Original research,No,Yes,516,Clinical/epidemiological research,Case report
517,"Moulin, New Microbes New Infect, 2016",Moulin,"Moulin, E., Selby, K., Cherpillod, P., Kaiser, L., Boillat-Blanco, N.","Simultaneous outbreaks of dengue, chikungunya and Zika virus infections: diagnosis challenge in a returning traveller with nonspecific febrile illness",New Microbes New Infect,11,,06. Jul,2016,2010-present,March 24, 2016,27006779,10.1016/j.nmni.2016.02.003,1091,English,,"Infectious Diseases Service, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland., Department of Ambulatory Care and Community Medicine, Lausanne, Switzerland., Swiss Reference Centre for Emerging Viral Diseases, Laboratory of Virology, University Hospital of Geneva, Geneva, Switzerland., Swiss Reference Centre for Emerging Viral Diseases, Laboratory of Virology, University Hospital of Geneva, Geneva, Switzerland; Infectious Diseases Service, University Hospital of Geneva, Geneva, Switzerland., Infectious Diseases Service, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland; Department of Ambulatory Care and Community Medicine, Lausanne, Switzerland.",,,,,"Chikungunya, Zika, dengue, diagnostic algorithm, outbreak",Zika virus is an emerging flavivirus that is following the path of dengue and chikungunya. The three Aedes-borne viruses cause simultaneous outbreaks with similar clinical manifestations which represents a diagnostic challenge in ill returning travellers. We report the first Zika virus infection case imported to Switzerland and present a diagnostic algorithm.,Pubmed,March 31, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Original research,No,Yes,517,Clinical/epidemiological research,Case report
518,"Lopes, Rev Assoc Med Bras, 2016",Lopes,"Lopes, M. H., Miyaji, K. T., Infante, V.",Zika virus,Rev Assoc Med Bras,62,1,04. Sep,2016,2010-present,March 24, 2016,27008481,10.1590/1806-9282.62.01.4,1089,English,,"Department of Infectious and Parasitic Diseases, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil., Hospital das Clinicas, FM, USP, Sao Paulo, SP, Brazil.",,,,,,,Pubmed,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Yes,Review,No,Yes,518,Clinical/epidemiological research,Epidemiological/clinical review
519,"Barton, Cmaj, 2016",Barton,"Barton, M. A., Salvadori, M. I.",Zika virus and microcephaly,Cmaj,,,,2016,2010-present,March 24, 2016,27001741,10.1503/cmaj.160179,1097,English,,"Division of Paediatric Infectious Diseases, Department of Paediatrics, University of Western Ontario, London, Ont.",,,,,,,Pubmed,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,519,,
520,"Anaya, BMC Med, 2016",Anaya,"Anaya, J. M., Ramirez-Santana, C., Salgado-Castaneda, I., Chang, C., Ansari, A., Gershwin, M. E.",Zika virus and neurologic autoimmunity: the putative role of gangliosides,BMC Med,14,1,49,2016,2010-present,March 24, 2016,27001187,10.1186/s12916-016-0601-y,1098,English,,"Center for Autoimmune Diseases Research (CREA), Universidad del Rosario, Bogota, Colombia. anayajm@gmail.com., Center for Autoimmune Diseases Research (CREA), Universidad del Rosario, Bogota, Colombia., Servicio de Neurologia, Hospital Central de la Policia, Bogota, Colombia., Division of Rheumatology, Allergy and Clinical Immunology, University of California Davis, School of Medicine, Davis, CA, USA., Department of Pathology, Emory University School of Medicine, Atlanta, GA, USA.",,,,,"Autoimmunity, Gangliosides, Guillain-Barre syndrome, Microcephaly, Zika virus","An increasing number of severe neurological complications associated with Zika virus (ZIKV), chiefly Guillain-Barre syndrome (GBS) and primary microcephaly, have led the World Health Organization to declare a global health emergency. Molecular mimicry between glycolipids and surface molecules of infectious agents explain most of the cases of GBS preceded by infection, while a direct toxicity of ZIKV on neural cells has been raised as the main mechanism by which ZIKV induces microcephaly. Gangliosides are crucial in brain development, and their expression correlates with neurogenesis, synaptogenesis, synaptic transmission, and cell proliferation. Targeting the autoimmune response to gangliosides may represent an underexploited opportunity to examine the increased incidence of neurological complications related to ZIKV infection.",Pubmed,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,520,,
521,"Millichap, Pediatr Neurol Briefs, 2016",Millichap,"Millichap, J. G.",Zika Virus Infection and Microcephaly,Pediatr Neurol Briefs,30,1,8,2016,2010-present,March 24, 2016,27004142,10.15844/pedneurbriefs-30-1-7,1096,English,,"Division of Neurology, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL; Departments of Pediatrics and Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL.",,,,,"Aedes mosquitoes, Brazil, Microcephaly, Zika virus",A Task Force established by the Brazil Ministry of Health investigated the possible association of microcephaly with Zika virus infection during pregnancy and a registry for microcephaly cases among women suspected to have had Zika virus infection during pregnancy.,Pubmed,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,521,,
522,"Steele, Clin Pediatr (Phila), 2016",Steele,"Steele, R. W.",Zika Virus: An Explosive Pandemic and a New TORCH Agent,Clin Pediatr (Phila),,,,2016,2010-present,March 24, 2016,27000068,10.1177/0009922816638660,1100,English,,"University of Queensland School of Medicine, Herston, Queensland, Australia Tulane University School of Medicine, New Orleans, LA, USA Ochsner Children's Health Center, New Orleans, LA, USA RWSteele@aol.com.",,,,,,,Pubmed,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,522,,
523,"Olson, MMWR Morb Mortal Wkly Rep, 2016",Olson,"Olson, C. K., Iwamoto, M., Perkins, K. M., Polen, K. N., Hageman, J., Meaney-Delman, D., Igbinosa,, II, Khan, S., Honein, M. A., Bell, M., Rasmussen, S. A., Jamieson, D. J.","Preventing Transmission of Zika Virus in Labor and Delivery Settings Through Implementation of Standard Precautions - United States, 2016",MMWR Morb Mortal Wkly Rep,65,11,290-2,2016,2010-present,March 25, 2016,27010422,10.15585/mmwr.mm6511e3,1087,English,,,,,,,,"Zika virus transmission was detected in the Region of the Americas (Americas) in Brazil in May 2015, and as of March 21, 2016, local mosquito-borne transmission of Zika virus had been reported in 32 countries and territories in the Americas, including Puerto Rico and the U.S. Virgin Islands.* Most persons infected with Zika virus have a mild illness or are asymptomatic. However, increasing evidence supports a link between Zika virus infection during pregnancy and adverse pregnancy and birth outcomes (1), and a possible association between recent Zika virus infection and Guillain-Barre syndrome has been reported (2). Although Zika virus is primarily transmitted through the bite of Aedes species of mosquitoes, sexual transmission also has been documented (3). Zika virus RNA has been detected in a number of body fluids, including blood, urine, saliva, and amniotic fluid (3-5), and whereas transmission associated with occupational exposure to these body fluids is theoretically possible, it has not been documented. Although there are no reports of transmission of Zika virus from infected patients to health care personnel or other patients, minimizing exposures to body fluids is important to reduce the possibility of such transmission. CDC recommends Standard Precautions in all health care settings to protect both health care personnel and patients from infection with Zika virus as well as from blood-borne pathogens (e.g., human immunodeficiency virus [HIV] and hepatitis C virus [HCV]) (6). Because of the potential for exposure to large volumes of body fluids during the labor and delivery process and the sometimes unpredictable and fast-paced nature of obstetrical care, the use of Standard Precautions in these settings is essential to prevent possible transmission of Zika virus from patients to health care personnel.",Pubmed,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,No,Comment/Editorial/Perspective/Letter,No,Yes,523,,
524,"Karwowski, Pediatrics, 2016",Karwowski,"Karwowski, M. P., Nelson, J. M., Staples, J. E., Fischer, M., Fleming-Dutra, K. E., Villanueva, J., Powers, A. M., Mead, P., Honein, M. A., Moore, C. A., Rasmussen, S. A.",Zika Virus Disease: A CDC Update for Pediatric Health Care Providers,Pediatrics,,,,2016,2010-present,March 25, 2016,27009036,10.1542/peds.2016-0621,1088,English,http://www.ncbi.nlm.nih.gov/pubmed/27009036,"Epidemic Intelligence Service, Divisions of Environmental Hazards and Health Effects, National Center for Environment Health., Epidemic Intelligence Service, Nutrition, Physical Activity, and Obesity, National Center for Chronic Disease and Health Promotion., Vector-Borne Diseases, National Center for Emerging and Zoonotic Infectious Diseases., Healthcare Quality Promotion, National Center for Emerging and Zoonotic Infectious Diseases., Preparedness and Emerging Infections, National Center for Emerging and Zoonotic Infectious Diseases., Congenital and Developmental Disorders, National Center on Birth Defects and Developmental Disabilities, and., Public Health Information Dissemination, Center for Surveillance, Epidemiology, and Laboratory Services, Centers for Disease Control and Prevention, Atlanta, Georgia skr9@cdc.gov.",,,,,,"Zika virus is a mosquito-borne flavivirus discovered in Africa in 1947. Most persons with Zika virus infection are asymptomatic; symptoms when present are generally mild and include fever, maculopapular rash, arthralgia, and conjunctivitis. Since early 2015, Zika virus has spread rapidly through the Americas, with local transmission identified in 31 countries and territories as of February 29, 2016, including several US territories. All age groups are susceptible to Zika virus infection, including children. Maternal-fetal transmission of Zika virus has been documented; evidence suggests that congenital Zika virus infection is associated with microcephaly and other adverse pregnancy and infant outcomes. Perinatal transmission has been reported in 2 cases; 1 was asymptomatic, and the other had thrombocytopenia and a rash. Based on limited information, Zika virus infection in children is mild, similar to that in adults. The long-term sequelae of congenital, perinatal, and pediatric Zika virus infection are largely unknown. No vaccine to prevent Zika virus infection is available, and treatment is supportive. The primary means of preventing Zika virus infection is prevention of mosquito bites in areas with local Zika virus transmission. Given the possibility of limited local transmission of Zika virus in the continental United States and frequent travel from affected countries to the United States, US pediatric health care providers need to be familiar with Zika virus infection. This article reviews the Zika virus, its epidemiologic characteristics, clinical presentation, laboratory testing, treatment, and prevention to assist providers in the evaluation and management of children with possible Zika virus infection.",Pubmed,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Yes,Review,No,Yes,524,Clinical/epidemiological research,Epidemiological/clinical review
525,"Todd, Am J Nurs, 2016",Todd,"Todd, B.",Zika Virus: An Unfolding Epidemic,Am J Nurs,116,4,59-60,2016,2010-present,March 25, 2016,27011140,10.1097/01.naj.0000482140.35295.57,1086,English,,AJN Clinical Editor.,,,,,,What we know now about this emerging global threat.,Pubmed,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,525,,
526,"Huang, J Formos Med Assoc, 2016",Huang,"Huang, A. S.; Shu, P. Y.; Yang, C. H.",A new reportable disease is born: Taiwan Centers for Disease Control's response to emerging Zika virus infection,J Formos Med Assoc,,,,2016,2010-present,March 26, 2016,27013110,10.1016/j.jfma.2016.03.002,1082,English,http://www.ncbi.nlm.nih.gov/pubmed/27013110,"Division of Acute Infectious Diseases, Taiwan Centers for Disease Control, Taipei, Taiwan.; Center for Research, Diagnostics and Vaccine Development, Taiwan Centers for Disease Control, Taipei, Taiwan.; Division of Acute Infectious Diseases, Taiwan Centers for Disease Control, Taipei, Taiwan. Electronic address: inf@cdc.gov.tw.",,,,,,"Zika virus infection, usually a mild disease transmitted through the bite of Aedes mosquitos, has been reported to be possibly associated with microcephaly and neurologic complications. Taiwan's first imported case of Zika virus infection was found through fever screening at airport entry in January 2016. No virus was isolated from patient's blood taken during acute illness; however, PCR products showed that the virus was of Asian lineage closely related to virus from Cambodia. To prevent Zika virus from spreading in Taiwan, the Taiwan Centers for Disease Control has strengthened efforts in quarantine and surveillance, increased Zika virus infection diagnostic capacity, implemented healthcare system preparedness plans, and enhanced vector control program through community mobilization and education. Besides the first imported case, no additional cases of Zika virus infection have been identified. Furthermore, no significant increase in the number of microcephaly or Guillain- Barre Syndrome has been observed in Taiwan. To date, there have been no autochthonous transmissions of Zika virus infection.",Pubmed,March 31, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Original research,No,Yes,526,Clinical/epidemiological research,Case report
527,"Huang, J Formos Med Assoc, 2016",Huang,"Huang, L. M.",How can we deal with Zika virus infection?,J Formos Med Assoc,,,,2016,2010-present,March 26, 2016,27013108,10.1016/j.jfma.2016.03.001,1083,English,http://www.ncbi.nlm.nih.gov/pubmed/27013108,"Department of Pediatrics, National Taiwan University Children's Hospital, Taipei, Taiwan. Electronic address: lmhuang@ntu.edu.tw.",,,,,,,Pubmed,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,527,,
528,"Pessoa, Medicine (Baltimore), 2016",Pessoa,"Pessoa, R.; Patriota, J. V.; Lourdes de Souza, Md; Felix, A. C.; Mamede, N.; Sanabani, S. S.","Investigation Into an Outbreak of Dengue-like Illness in Pernambuco, Brazil, Revealed a Cocirculation of Zika, Chikungunya, and Dengue Virus Type 1",Medicine (Baltimore),95,12,e3201,2016,2010-present,March 26, 2016,27015222,10.1097/MD.0000000000003201,1079,English,http://www.ncbi.nlm.nih.gov/pubmed/27015222,"From the Clinical Laboratory, Department of Pathology (RP, SSS), Hospital das Clinicas (HC), School of Medicine, University of Sao Paulo, Sao Paulo; Municipal Hospital of Tuparetama (JVP, MDLDS, ACF, NM), Pernambuco; and Department of Virology (SSS), Sao Paulo Institute of Tropical Medicine, Sao Paulo, Brazil.",,,,,,"In April 2015, an outbreak of dengue-like illness occurred in Tuparetama, a small city in the northeast region of Brazil; this outbreak was characterized by its fast expansion. An investigation was initiated to identify the viral etiologies and advise the health authorities on implementing control measures to contain the outbreak. This is the first report of this outbreak in the northeast, even though a few cases were documented earlier in a neighboring city.Plasma samples were obtained from 77 suspected dengue patients attending the main hospital in the city. Laboratory assays, such as real-time reverse transcription polymerase chain reaction, virus cDNA sequencing, and enzyme-linked immunosorbent assay, were employed to identify the infecting virus and molecular phylogenetic analysis was performed to define the circulating viral genotypes.RNA of Zika virus (ZIKV) and Dengue virus (DENV) or IgM antibodies (Abs) to DENV or chikungunya (CHIKV) were detected in 40 of the 77 plasma samples (51.9%). DENV was found in 9 patients (11.7%), ZIKV was found in 31 patients (40.2%), CHIKV in 1 patient (1.3%), and coinfection of DENV and ZIKV was detected in 2 patients (2.6%). The phylogenetic analysis of 2 available partial DENV and 14 ZIKV sequences revealed the identities of genotype 1 and the Asiatic lineage, respectively.Consistent with recent reports from the same region, our results showed that the ongoing outbreak is caused by ZIKV, DENV, and CHIKV. This emphasizes the need for a routine and differential diagnosis of arboviruses in patients with dengue-like illness. Coordinated efforts are necessary to contain the outbreak. Continued surveillance will be important to assess the effectiveness of current and future prevention strategies.",Pubmed,March 31, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Original research,No,Yes,528,Clinical/epidemiological research,Ecological study/outbreak report
529,"Sikka, J Glob Infect Dis, 2016",Sikka,"Sikka, V.; Chattu, V. K.; Popli, R. K.; Galwankar, S. C.; Kelkar, D.; Sawicki, S. G.; Stawicki, S. P.; Papadimos, T. J.",The Emergence of Zika Virus as a Global Health Security Threat: A Review and a Consensus Statement of the INDUSEM Joint working Group (JWG),J Glob Infect Dis,8,1,Mrz 15,2016,2010-present,March 26, 2016,27013839,10.4103/0974-777X.176140,1080,English,http://www.ncbi.nlm.nih.gov/pubmed/27013839,"Department of Emergency Medicine, Veterans Affairs Medical Center, Orlando, USA.; Institute for International Relations, The University of West Indies, St. Augustine, Trinidad and Tobago, USA.; Digestive Disease Consultants of Central Florida, Altamonte Springs, Florida, USA.; Department of Emergency Medicine, University of Florida, Jacksonville, Florida, USA.; Department of Medical Microbiology and Immunology, College of Medicine and the Life Sciences, University of Toledo, Toledo, USA.; Department of Research and Innovation, St. Luke's University Health Network, Bethlehem, Pennsylvania, USA.; Department of Anesthesiology, The Ohio State University College of Medicine, Columbus, Ohio, USA.",,,,,Arbovirus; Flavivirus; Global health security; Public health; Public health emergency of international concern; Viral vector control; Zika virus,"The Zika virus (ZIKV), first discovered in 1947, has emerged as a global public health threat over the last decade, with the accelerated geographic spread of the virus noted during the last 5 years. The World Health Organization (WHO) predicts that millions of cases of ZIKV are likely to occur in the Americas during the next 12 months. These projections, in conjunction with suspected Zika-associated increase in newborn microcephaly cases, prompted WHO to declare public health emergency of international concern. ZIKV-associated illness is characterized by an incubation period of 3-12 days. Most patients remain asymptomatic (i.e., ~80%) after contracting the virus. When symptomatic, clinical presentation is usually mild and consists of a self-limiting febrile illness that lasts approximately 2-7 days. Among common clinical manifestations are fever, arthralgia, conjunctivitis, myalgia, headache, and maculopapular rash. Hospitalization and complication rates are low, with fatalities being extremely rare. Newborn microcephaly, the most devastating and insidious complication associated with the ZIKV, has been described in the offspring of women who became infected while pregnant. Much remains to be elucidated about the timing of ZIKV infection in the context of the temporal progression of pregnancy, the corresponding in utero fetal development stage(s), and the risk of microcephaly. Without further knowledge of the pathophysiology involved, the true risk of ZIKV to the unborn remains difficult to quantify and remediate. Accurate, portable, and inexpensive point-of-care testing is required to better identify cases and manage the current and future outbreaks of ZIKV, including optimization of preventive approaches and the identification of more effective risk reduction strategies. In addition, much more work needs to be done to produce an effective vaccine. Given the rapid geographic spread of ZIKV in recent years, a coordinated local, regional, and global effort is needed to generate sufficient resources and political traction to effectively halt and contain further expansion of the current outbreak.",Pubmed,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,529,,
530,"Gulland, BMJ, 2016",Gulland,"Gulland, A.",WHO's Chan warns over spread of Zika virus beyond Latin America,BMJ,352,,i1739,2016,2010-present,March 26, 2016,27012725,10.1136/bmj.i1739,1084,English,,London.,,,,,,,Pubmed,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,News item or lay press,,,No,Yes,530,,
531,"Faria, Science, 2016",Faria,"Faria, N. R., Azevedo, R. D., Kraemer, M. U., Souza, R., Cunha, M. S., Hill, S. C., Theze, J., Bonsall, M. B., Bowden, T. A., Rissanen, I., Rocco, I. M., Nogueira, J. S., Maeda, A. Y., Vasami, F. G., Macedo, F. L., Suzuki, A., Rodrigues, S. G., Cruz, A. C., Nunes, B. T., Medeiros, D. B., Rodrigues, D. S., Nunes Queiroz, A. L., Silva, E. V., Henriques, D. F., Travassos da Rosa, E. S., de Oliveira, C. S., Martins, L. C., Vasconcelos, H. B., Casseb, L. M., Simith, D. B., Messina, J. P., Abade, L., Lourenco, J., Alcantara, L. C., Lima, M. M., Giovanetti, M., Hay, S. I., de Oliveira, R. S., Lemos, P. D., Oliveira, L. F., de Lima, C. P., da Silva, S. P., Vasconcelos, J. M., Franco, L., Cardoso, J. F., Vianez-Junior, J. L., Mir, D., Bello, G., Delatorre, E., Khan, K., Creatore, M., Coelho, G. E., de Oliveira, W. K., Tesh, R., Pybus, O. G., Nunes, M. R., Vasconcelos, P. F.",Zika virus in the Americas: Early epidemiological and genetic findings,Science,,,,2016,2010-present,March 26, 2016,27013429,10.1126/science.aaf5036,1081,English,,"Center for Technological Innovation, Evandro Chagas Institute, Ministry of Health, Ananindeua, PA, 67030-000, Brazil. Department of Zoology, University of Oxford, South Parks Road, Oxford, OX1 3PS UK., Department of Arbovirology and Hemorrhagic Fevers, Evandro Chagas Institute, Ministry of Health, Ananindeua, Para State, Brazil., Department of Zoology, University of Oxford, South Parks Road, Oxford, OX1 3PS UK., Instituto Adolfo Lutz, University of Sao Paulo, Brazil., Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK., Department of Zoology, University of Oxford, South Parks Road, Oxford, OX1 3PS UK. Metabiota, San Francisco, CA 94104, USA., Oswaldo Cruz Foundation (FIOCRUZ), Salvador, Bahia, Brazil., Centre of Post Graduation in Collective Health, Department of Health, Universidade Estadual de Feira de Santana, Feira de Santana, Bahia, Brazil., Institute for Health Metrics and Evaluation, University of Washington, Seattle, WA, USA. Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK., Center for Technological Innovation, Evandro Chagas Institute, Ministry of Health, Ananindeua, PA, 67030-000, Brazil., Laboratorio de AIDS and Imunologia Molecular, Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, Brazil., Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Canada. Department of Medicine, Division of Infectious Diseases, University of Toronto, Canada., Dalla Lana School of Public Health, University of Toronto, Canada., Brazilian Ministry of Health, Brasilia, Brazil., Department of Pathology, University of Texas Medical Branch, Galveston, TX, USA., Department of Zoology, University of Oxford, South Parks Road, Oxford, OX1 3PS UK. Metabiota, San Francisco, CA 94104, USA. oliver.pybus@zoo.ox.ac.uk marcionunesbrasil@yahoo.com.br pedrovasconcelos@iec.pa.gov.br., Center for Technological Innovation, Evandro Chagas Institute, Ministry of Health, Ananindeua, PA, 67030-000, Brazil. Department of Pathology, University of Texas Medical Branch, Galveston, TX, USA. oliver.pybus@zoo.ox.ac.uk marcionunesbrasil@yahoo.com.br pedrovasconcelos@iec.pa.gov.br., Department of Arbovirology and Hemorrhagic Fevers, Evandro Chagas Institute, Ministry of Health, Ananindeua, Para State, Brazil. oliver.pybus@zoo.ox.ac.uk marcionunesbrasil@yahoo.com.br pedrovasconcelos@iec.pa.gov.br.",Brazil,Americas,Brazil,Public/Government,,"Brazil has experienced an unprecedented epidemic of Zika virus (ZIKV), with ~30,000 cases reported to date. ZIKV was first detected in Brazil in May 2015 and cases of microcephaly potentially associated with ZIKV infection were identified in November 2015. Using next generation sequencing we generated seven Brazilian ZIKV genomes, sampled from four self-limited cases, one blood donor, one fatal adult case, and one newborn with microcephaly and congenital malformations. Phylogenetic and molecular clock analyses show a single introduction of ZIKV into the Americas, estimated to have occurred between May-Dec 2013, more than 12 months prior to the detection of ZIKV in Brazil. The estimated date of origin coincides with an increase in air passengers to Brazil from ZIKV endemic areas, and with reported outbreaks in Pacific Islands. ZIKV genomes from Brazil are phylogenetically interspersed with those from other South American and Caribbean countries. Mapping mutations onto existing structural models revealed the context of viral amino acid changes present in the outbreak lineage; however no shared amino acid changes were found among the three currently available virus genomes from microcephaly cases. Municipality-level incidence data indicate that reports of suspected microcephaly in Brazil best correlate with ZIKV incidence around week 17 of pregnancy, although this does not demonstrate causation. Our genetic description and analysis of ZIKV isolates in Brazil provide a baseline for future studies of the evolution and molecular epidemiology in the Americas of this emerging virus.",Pubmed,March 31, 2016,Yes,,Yes,,Scientific (journal) article,Yes,Original research,Yes,No,912,Clinical/epidemiological research,Ecological study/outbreak report
532,"Hamel, Microbes Infect, 2016",Hamel,"Hamel, R., Liegeois, F., Wichit, S., Pompon, J., Diop, F., Talignani, L., Thomas, F., Despres, P., Yssel, H., Misse, D.","Zika virus: epidemiology, clinical features and host-virus interaction",Microbes Infect,,,,2016,2010-present,March 26, 2016,27012221,10.1016/j.micinf.2016.03.009,1085,English,,"Laboratoire MIVEGEC, UMR 224 IRD/CNRS/UM1, Montpellier, France., Laboratoire MIVEGEC, UMR 224 IRD/CNRS/UM1, Montpellier, France; Programme in Emerging Infectious Disease, Duke-NUS Medical School, 8 College Road, Singapore 169857, Singapore., UM 134 PIMIT, Universite de La Reunion, Inserm U1187, CNRS 9192, IRD 249, GIP-CYROI, 97491 Saint Clotilde, La Reunion, France., Centre d'Immunologie et des Maladies Infectieuses, Inserm, U1135, Sorbonne Universites, UPMC, APHP Hopital Pitie-Salpetriere, Paris, France., Laboratoire MIVEGEC, UMR 224 IRD/CNRS/UM1, Montpellier, France. Electronic address: dorothee.misse@ird.fr.",,,,,"Arbovirus, Epidemiology, Host-pathogen interactions, Innate immunity, Vector, Zika","Very recently, Zika virus (ZIKV) has gained a medical importance following the large-scale epidemics in South Pacific and Latin America. This paper reviews information on the epidemiology and clinical features of Zika disease with a particular emphasis on the host-virus interactions that contribute to the pathogenicity of ZIKV in humans.",Pubmed,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Yes,Review,No,Yes,532,Clinical/epidemiological research,Epidemiological/clinical review
533,"Palacios, Vaccine, 2016",Palacios,"Palacios, R.; Poland, G. A.; Kalil, J.","Another emerging arbovirus, another emerging vaccine: Targeting Zika virus",Vaccine,,,,2016,2010-present,March 27, 2016,27015734,10.1016/j.vaccine.2016.03.059,1078,English,http://www.ncbi.nlm.nih.gov/pubmed/27015734,"Instituto Butantan, Sao Paulo, Brazil.; Mayo Vaccine Research Group, Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA.; Instituto Butantan, Sao Paulo, Brazil; Clinical Immunology and Allergy Division, University of Sao Paulo, Sao Paulo, Brazil. Electronic address: jorge.kalil@butantan.gov.br.",,,,,,,Pubmed,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,533,,
534,"Taylor, Travel Med Infect Dis, 2016",Taylor,"Taylor, K. A., Paterson, B. J.",Zika virus from a Pacific perspective: What are the risks to Australians?,Travel Med Infect Dis,,,,2016,2010-present,March 27, 2016,27016009,10.1016/j.tmaid.2016.03.006,1077,English,,"Hunter New England Population Health Unit, Hunter New England Local Health District, Australia; School of Population Health, University of Adelaide, Australia. Electronic address: kathryn.taylor1@hnehealth.nsw.gov.au., Hunter New England Population Health Unit, Hunter New England Local Health District, Australia; Hunter Medical Research Institute, University of Newcastle, Australia.",,,,,"Flavivirus, Travel medicine, Vector-borne disease, Zika virus infection",,Pubmed,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,534,,
535,"Farahnik, J Am Acad Dermatol, 2016",Farahnik,"Farahnik, B.; Beroukhim, K.; Blattner, C. M.; Young, J., 3rd",Cutaneous manifestations of the Zika virus,J Am Acad Dermatol,,,,2016,2010-present,March 28, 2016,27016775,10.1016/j.jaad.2016.02.1232,1076,English,http://www.ncbi.nlm.nih.gov/pubmed/27016775,"University of Vermont College of Medicine, Burlington, Vermont.; David Geffen School of Medicine at the University of California, Los Angeles, California.; Good Samaritan Regional Medical Center, Corvallis, Oregon.; Silver Falls Dermatology, Salem, Oregon. Electronic address: jyoung@silverfallsderm.net.",,,,,Zika virus; disease prevention and control; microcephaly; public health concerns; viral exanthem,,Pubmed,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,535,,
536,"Sadovsky, Placenta, 2016",Sadovsky,"Sadovsky, Y.; Clifton, V. L.; Knofler, M.",Editorial: ZIKA virus and placenta,Placenta,40,,A1,2016,2010-present,March 29, 2016,27016785,10.1016/j.placenta.2016.03.008,1075,English,http://www.ncbi.nlm.nih.gov/pubmed/27016785,,,,,,,,Pubmed,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,536,,
537,"Lucchese, Autoimmun Rev, 2016",Lucchese,"Lucchese, G., Kanduc, D.","Zika virus and autoimmunity: from microcephaly to Guillain-Barre syndrome, and beyond",Autoimmun Rev,,,,2016,2010-present,March 29, 2016,27019049,10.1016/j.autrev.2016.03.020,1074,English,,"Brain and Language Laboratory, Free University of Berlin, 14195 Berlin, Germany., Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari, 70126 Bari, Italy.",Germany,Europe,Italy,Mixed,"Aicardi-Goutieres syndromes, Guillain-Barre-like syndromes, Zika virus infection, autoimmunity, brain calcification, centriolar and centrosomal proteins, crossreactivity, microcephaly, ocular anomalies, peptide sharing","Zika virus (ZIKV) infection during pregnancy ma be linked to fetal neurological complications that include brain damage and microcephaly. How the viral infection relates to fetal brain malformations is unknown. This study analyzes ZIKV polyprotein for peptide sharing with human proteins that when altered, associate with microcephaly and brain calcifications. Results highlight a vast viral versus human peptide commonality that, in particular, involves centriolar and centrosomal components canonically cataloged as microcephaly proteins, i.e., C2CD3, CASC5, CP131, GCP4, KIF2A, STIL, and TBG. Likewise, a search for ZIKV peptide occurrences in human proteins linked to Guillain-Barre-like syndromes also show a high, unexpected level of peptide sharing. Of note, further analyses using the Immune Epitope DataBase (IEDB) resource show that many of the shared peptides are endowed with immunological potential. The data indicate that immune reactions following ZIKV infection might be a considerable source of crossreactions with brain-specific proteins and might contribute to the ZIKV-associated neuropathologic sequelae.",Pubmed,March 31, 2016,Yes,,Yes,,Scientific (journal) article,Yes,Original research,No,Yes,537,Basic and applied biomedical research,Sequence analysis and phylogenetics
538,"Rossi, Am J Trop Med Hyg, 2016",Rossi,"Rossi, S. L.; Tesh, R. B.; Azar, S. R.; Muruato, A. E.; Hanley, K. A.; Auguste, A. J.; Langsjoen, R. M.; Paessler, S.; Vasilakis, N.; Weaver, S. C.",Characterization of a Novel Murine Model to Study Zika Virus,Am J Trop Med Hyg,,,,2016,2010-present,March 30, 2016,27022155,10.4269/ajtmh.16-0111,1071,English,http://www.ncbi.nlm.nih.gov/pubmed/27022155,"Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, Texas; Department of Pathology, University of Texas Medical Branch, Galveston, Texas; Institute for Translational Science, University of Texas Medical Branch, Galveston, Texas; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas; Sealy Center for Vaccine Development, University of Texas Medical Branch, Galveston, Texas; Department of Biology, New Mexico State University, Las Cruces, New Mexico slrossi@utmb.edu.; Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, Texas; Department of Pathology, University of Texas Medical Branch, Galveston, Texas; Institute for Translational Science, University of Texas Medical Branch, Galveston, Texas; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas; Sealy Center for Vaccine Development, University of Texas Medical Branch, Galveston, Texas; Department of Biology, New Mexico State University, Las Cruces, New Mexico.",United States,Americas,United States,Mixed,,"The mosquito-borne Zika virus (ZIKV) is responsible for an explosive ongoing outbreak of febrile illness across the Americas. ZIKV was previously thought to cause only a mild, flu-like illness, but during the current outbreak, an association with Guillain-Barre syndrome and microcephaly in neonates has been detected. A previous study showed that ZIKV requires murine adaptation to generate reproducible murine disease. In our study, a low-passage Cambodian isolate caused disease and mortality in mice lacking the interferon (IFN) alpha receptor (A129 mice) in an age-dependent manner, but not in similarly aged immunocompetent mice. In A129 mice, viremia peaked at approximately 107plaque-forming units/mL by day 2 postinfection (PI) and reached high titers in the spleen by day 1. ZIKV was detected in the brain on day 3 PI and caused signs of neurologic disease, including tremors, by day 6. Robust replication was also noted in the testis. In this model, all mice infected at the youngest age (3 weeks) succumbed to illness by day 7 PI. Older mice (11 weeks) showed signs of illness, viremia, and weight loss but recovered starting on day 8. In addition, AG129 mice, which lack both type I and II IFN responses, supported similar infection kinetics to A129 mice, but with exaggerated disease signs. This characterization of an Asian lineage ZIKV strain in a murine model, and one of the few studies reporting a model of Zika disease and demonstrating age-dependent morbidity and mortality, could provide a platform for testing the efficacy of antivirals and vaccines.",Pubmed,March 31, 2016,Yes,,Yes,,Scientific (journal) article,Yes,Original research,No,Yes,538,Basic and applied biomedical research,Animal experiment
539,"Kotton, Transplantation, 2016",Kotton,"Kotton, C. N.",Zika Virus and Solid Organ Transplantation: Significant Pathogen or Harbinger of Things to Come?,Transplantation,,,,2016,2010-present,March 30, 2016,27023395,10.1097/tp.0000000000001179,1070,English,,"1Transplant and Immunocompromised Host Infectious Diseases, Infectious Diseases Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA.",,,,,,,Pubmed,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,539,,
540,"Goeijenbier, Neth J Med, 2016",Goeijenbier,"Goeijenbier, M., Slobbe, L., van der Eijk, A., de Mendonca Melo, M., Koopmans, M. P., Reusken, C. B.",Zika virus and the current outbreak: an overview,Neth J Med,74,3,104-9,2016,2010-present,March 30, 2016,27020989,,1073,English,,"Department of Viroscience, Erasmus MC, the Netherlands.",,,,,,"Zika virus (ZIKV), a mosquito-borne flavivirus closely related to yellow fever virus and dengue virus, is currently causing a large outbreak in the Americas. Historically, ZIKV infection was considered a sporadic, relatively mild disease characterised by fever, maculopapular rash, conjunctivitis and often arthralgia. However, current observational studies suggest that ZIKV may cause more severe neurological sequelae such as Guillain-Barre syndrome, and birth defects, mainly microcephaly, in babies of whom the mother was infected with ZIKV during pregnancy. This article provides a clinically focussed overview of ZIKV, with emphasis on the current outbreak, clinical manifestations, diagnostic tools and caveats.",Pubmed,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Yes,Review,No,Yes,540,Clinical/epidemiological research,Epidemiological/clinical review
541,"Vest, Disaster Med Public Health Prep, 2016",Vest,"Vest, K. G.",Zika Virus: A Basic Overview of an Emerging Arboviral Infection in the Western Hemisphere,Disaster Med Public Health Prep,,,01. Jun,2016,2010-present,March 30, 2016,27021935,10.1017/dmp.2016.43,1072,English,,"Center for Global Health Engagement,Uniformed Services University of the Health Sciences,Rockville,Maryland.",,,,,"Zika virus, arbovirus, epidemic","Since February 2015, Zika virus has spread throughout the Western Hemisphere, starting in Brazil. As of March 2016, autochthonous transmission has been reported in at least 31 countries or territories. For countries in the Americas, the spread of Zika virus, a previously unfamiliar disease, follows similar emerging infection introductions of West Nile virus and Chikungunya virus and their spread throughout the American continents and the Caribbean nations. The Pan American Health Organization and the World Health Organization have issued alerts and a Public Health Emergency of International Concern announcement related to the recent cluster of microcephaly cases and other neurological disorders in Brazil that are temporally associated with Zika virus, which highlights the possible adverse impact of viral infection. This article provides an overview of the Zika virus infection and presents the historical background of the virus, a description of the pathogen, the epidemiology and clinical spectrum of Zika virus infection, diagnosis and treatment approaches, and prevention and control measures. Understanding what is known about the virus and its clinical presentation will assist in prevention, detection, and response measures to reduce and control the spread of the virus throughout the Western Hemisphere. (Disaster Med Public Health Preparedness. 2016;page 1 of 6).",Pubmed,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Yes,Review,No,Yes,541,Clinical/epidemiological research,Epidemiological/clinical review
542,"Besnard, Eurosurveillance, 2016",Besnard,"Besnard, M; Eyrolle-Guigno,t D, Guillemette-Artur, P, Lastère, S, Bost-Bezeaud, F, Marcelis, L, Abadie, V, Garel, C, Moutard, M, Jouannic, J, Rozenberg, F, Leparc-Goffart, I, Mallet, H.",Congenital cerebral malformations and dysfunction in fetuses and newborns following the 2013 to 2014 Zika virus epidemic in French Polynesia,Eurosurveillance,21,13,,2016,2010-present,March 31, 2016,,10.2807/1560-7917.ES.2016.21.13.30181,1955,English,,Marianne Besnard (mbesnard@nohao.net),French Polynesia,Pacific,French Polynesia,Not reported/unknown,,"We detected an unusual increase in congenital cerebral malformations and dysfunction in fetuses and newborns in French Polynesia, following an epidemic of Zika virus (ZIKV), from October 2013 to March 2014. A retrospective review identified 19 cases, including eight with major brain lesions and severe microcephaly, six with severe cerebral lesions without microcephaly and five with brainstem dysfunction without visible malformations. Imaging revealed profound neurological lesions (septal and callosal disruption, ventriculomegaly, abnormal neuronal migration, cerebellar hypoplasia, occipital pseudocysts, brain calcifications). Amniotic fluid was drawn from seven cases at gestation weeks 20 to 29. ZIKV RNA was detected by RT-PCR and infectious ZIKV isolates were obtained in four of five microcephalic, but not in two non-microcephalic cases with severe brain lesions. Medical termination of pregnancy was performed in eleven cases; two cases with brainstem dysfunction died in the first months of life; six cases are alive, with severe neurological impairment. The results show that four of seven tested fetuses with major neurological injuries were infected with ZIKV in utero. For other non-microcephalic, congenital abnormalities we were not able to prove or exclude ZIKV infection retrospectively. The unusual occurrence of brain malformations or dysfunction without microcephaly following a ZIKV outbreak needs further studies.",Eurosurveillance,March 31, 2016,Yes,,Yes,,Scientific (journal) article,Yes,Original research,Yes,Yes,542,Clinical/epidemiological research,Case series
543,"Barreiro, AIDS Rev, 2016",Barreiro,"Barreiro, P.","Evolving RNA Virus Pandemics: HIV, HCV, Ebola, Dengue, Chikunguya, and now Zika!",AIDS Rev,18,1,54-5,2016,2010-present,March 31, 2016,27028271,,1067,English,http://www.ncbi.nlm.nih.gov/pubmed/27028271,"Infectious Diseases & Tropical Medicine, La Paz University Hospital, Madrid, Spain.",,,,,,"The Zika virus (ZIKV), a flavivirus related to yellow fever, dengue, and West Nile, originated in the Zika forest in Uganda and was discovered in a rhesus monkey in 1947. The disease now has 'explosive' pandemic potential, with outbreaks in Africa, Southeast Asia, the Pacific Islands, and the Americas. To date, the CDC has issued travel alerts for at least 30 countries and territories in Latin America, the Caribbean, Polynesia, and Cape Verde in Africa.",Pubmed,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,543,,
544,"Haug, N Engl J Med, 2016",Haug,"Haug, C. J., Kieny, M. P., Murgue, B.",The Zika Challenge,N Engl J Med,,,,2016,2010-present,March 31, 2016,27028782,10.1056/NEJMp1603734,1064,English,,"Dr. Haug is an international correspondent for the Journal; Dr. Kieny is the assistant director-general for health systems and innovation, and Dr. Murgue the project manager of the WHO R&D Blueprint, at the World Health Organization, Geneva.",,,,,,"There are many viruses that have similar characteristics to dengue, yellow fever, and Zika that have the potential to emerge. We don't know why Zika emerged now. But we know how to develop surveillance systems that will allow us to pick these viruses up if they start to move as Zika has.' This starting point was outlined by tropical medicine expert Duane Gubler at a World Health Organization (WHO) meeting in Geneva in early March. Gubler has spent his career studying tropical infectious diseases with an emphasis on dengue virus (DENV), a flavivirus closely related to Zika virus (ZIKV).1 His . . .",Pubmed,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,544,,
545,"Armstrong, MMWR Morb Mortal Wkly Rep, 2016",Armstrong,"Armstrong, P., Hennessey, M., Adams, M., Cherry, C., Chiu, S., Harrist, A., Kwit, N., Lewis, L., McGuire, D. O., Oduyebo, T., Russell, K., Talley, P., Tanner, M., Williams, C., Basile, J., Brandvold, J., Calvert, A., Cohn, A., Fischer, M., Goldman-Israelow, B., Goodenough, D., Goodman, C., Hills, S., Kosoy, O., Lambert, A., Lanciotti, R., Laven, J., Ledermann, J., Lehman, J., Lindsey, N., Mead, P., Mossel, E., Nelson, C., Nichols, M., O'Leary, D., Panella, A., Powers, A., Rabe, I., Reagan-Steiner, S., Staples, J. E., Velez, J.","Travel-Associated Zika Virus Disease Cases Among U.S. Residents - United States, January 2015-February 2016",MMWR Morb Mortal Wkly Rep,65,11,286-9,2016,2010-present,March 31, 2016,27023833,10.15585/mmwr.mm6511e1,1069,English,http://www.ncbi.nlm.nih.gov/pubmed/27023833,,,,,,,"Zika virus is an emerging mosquito-borne flavivirus. Recent outbreaks of Zika virus disease in the Pacific Islands and the Region of the Americas have identified new modes of transmission and clinical manifestations, including adverse pregnancy outcomes. However, data on the epidemiology and clinical findings of laboratory-confirmed Zika virus disease remain limited. During January 1, 2015-February 26, 2016, a total of 116 residents of 33 U.S. states and the District of Columbia had laboratory evidence of recent Zika virus infection based on testing performed at CDC. Cases include one congenital infection and 115 persons who reported recent travel to areas with active Zika virus transmission (n = 110) or sexual contact with such a traveler (n = 5). All 115 patients had clinical illness, with the most common signs and symptoms being rash (98%; n = 113), fever (82%; 94), and arthralgia (66%; 76). Health care providers should educate patients, particularly pregnant women, about the risks for, and measures to prevent, infection with Zika virus and other mosquito-borne viruses. Zika virus disease should be considered in patients with acute onset of fever, rash, arthralgia, or conjunctivitis, who traveled to areas with ongoing Zika virus transmission (http://www.cdc.gov/zika/geo/index.html) or who had unprotected sex with a person who traveled to one of those areas and developed compatible symptoms within 2 weeks of returning.",Pubmed,March 31, 2016,Yes,,No,"Zika, not relevant to causality framework",Scientific (journal) article,No,Original research,No,Yes,545,Clinical/epidemiological research,Case series
546,"Maurice, Lancet, 2016",Maurice,"Maurice, J.",WHO meeting thrashes out R&D strategy against Zika,Lancet,387,10024,1147,2016,2010-present,March 31, 2016,27025322,10.1016/s0140-6736(16)30012-5,1068,English,,,,,,,,WHO convened a multidisciplinary consultation last week to identify the tools and interventions needed to outsmart the Zika epidemic. John Maurice reports from Geneva.,Pubmed,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Yes,Other,No,Yes,546,,
547,"Petersen, N Engl J Med, 2016",Petersen,"Petersen, L. R., Jamieson, D. J., Powers, A. M., Honein, M. A.",Zika Virus,N Engl J Med,,,,2016,2010-present,March 31, 2016,27028561,10.1056/NEJMra1602113,1066,English,,"From the Division of Vector-Borne Diseases, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, CO (L.R.P., A.M.P.); and the Division of Reproductive Health, National Center for Chronic Disease Prevention and Health Promotion (D.J.J), and the Division of Congenital and Developmental Disorders, National Center on Birth Defects and Developmental Disabilities (M.A.H), Centers for Disease Control and Prevention, Atlanta.",,,,,,Zika virus is rapidly spreading throughout the Americas and the Caribbean. The association with microcephaly has led the WHO to declare a public health emergency. This review describes our current understanding of the characteristics of Zika virus infection.,Pubmed,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Yes,Review,No,Yes,547,Clinical/epidemiological research,Epidemiological/clinical review
548,"Drosten, Eurosurveillance, 2016",Drosten,"Drosten, C.",Zika virus and congenital malformations in perspective,Eurosurveillance,21,13,,2016,2010-present,March 31, 2016,,10.2807/1560-7917.ES.2016.21.13.30182,1954,,,,,,,,,,Eurosurveillance,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,548,,
549,"Driggers, N Engl J Med, 2016",Driggers,"Driggers, R. W., Ho, C. Y., Korhonen, E. M., Kuivanen, S., Jaaskelainen, A. J., Smura, T., Rosenberg, A., Hill, D. A., DeBiasi, R. L., Vezina, G., Timofeev, J., Rodriguez, F. J., Levanov, L., Razak, J., Iyengar, P., Hennenfent, A., Kennedy, R., Lanciotti, R., du Plessis, A., Vapalahti, O.",Zika Virus Infection with Prolonged Maternal Viremia and Fetal Brain Abnormalities,N Engl J Med,,,,2016,2010-present,March 31, 2016,27028667,10.1056/NEJMoa1601824,1065,English,,"From the Department of Gynecology and Obstetrics, Division of Maternal Fetal Medicine (R.W.D., J.T.), and the Department of Pathology (F.J.R.), Johns Hopkins University School of Medicine, Baltimore; the Division of Maternal Fetal Medicine, Sibley Memorial Hospital (R.W.D., J.T., J.R.), the Division of Pathology and Center for Genetic Medicine Research (C.-Y.H., A.R., D.A.H.), Division of Pediatric Infectious Diseases (R.L.D.), Department of Diagnostic Radiology and Imaging (G.V.), and the Fetal Medicine Institute, Division of Fetal and Transitional Medicine (A.P.), Children's National Health System, the Departments of Integrative Systems Biology (C.-Y.H., D.A.H.), Pediatrics and Microbiology, Immunology and Tropical Medicine (R.L.D.B.), and Radiology and Pediatrics (G.V.), George Washington University School of Medicine and Health Sciences, the Center for Policy, Planning and Evaluation (P.I.) and Centers for Disease Control and Prevention (CDC)-Council of State and Territorial Epidemiologists (CSTE) Applied Epidemiology Fellowship (A.H.), District of Columbia Department of Health, and One Medical Group (R.K.) - all in Washington, DC; the Departments of Virology (E.M.K., S.K., T.S., L.L., O.V.) and Veterinary Biosciences (E.M.K., O.V.), University of Helsinki, and the Department of Virology and Immunology, University of Helsinki and Helsinki University Hospital (A.J.J., O.V.), Helsinki; and the Arboviral Diseases Branch, Division of Vector-Borne Diseases, National Center for Emerging Zoonotic Infectious Diseases, CDC, Atlanta (R.L.).",United States,Americas,Finland,Not reported/unknown,,"The current outbreak of Zika virus (ZIKV) infection has been associated with an apparent increased risk of congenital microcephaly. We describe a case of a pregnant woman and her fetus infected with ZIKV during the 11th gestational week. The fetal head circumference decreased from the 47th percentile to the 24th percentile between 16 and 20 weeks of gestation. ZIKV RNA was identified in maternal serum at 16 and 21 weeks of gestation. At 19 and 20 weeks of gestation, substantial brain abnormalities were detected on ultrasonography and magnetic resonance imaging (MRI) without the presence of microcephaly or intracranial calcifications. On postmortem analysis of the fetal brain, diffuse cerebral cortical thinning, high ZIKV RNA loads, and viral particles were detected, and ZIKV was subsequently isolated.",Pubmed,March 31, 2016,Yes,,Yes,,Scientific (journal) article,Yes,Original research,No,Yes,549,Clinical/epidemiological research,Case report
550,"Elsaka, bioRxiv, 2016",Elsaka,"Elsaka, H.; Ahmed, E.",A fractional order network model for ZIKA,bioRxiv,,,,2016,2010-present,,,10.1101/039917,1946,,http://biorxiv.org/content/biorxiv/early/2016/02/18/039917.full.pdf,,,,,,,Zika is a fast spreading epidemic. So far it is known to have two transmission routes one via mosquito and the other is via sexual contact. It is dangerous on pregnant women otherwise it is mild,BiorXiv,March 31, 2016,Yes,,No,"Zika, not relevant to causality framework",Scientific (journal) article,No,Original research,No,Yes,550,Clinical/epidemiological research,Modelling study
551,"Triunfol, Lancet Infect Dis, 2016",Triunfol,"Triunfol, M.",A new mosquito-borne threat to pregnant women in Brazil,Lancet Infect Dis,16,2,156-7,2016,2010-present,,26723756,10.1016/S1473-3099(15)00548-4,1895,,http://www.ncbi.nlm.nih.gov/pubmed/26723756,,,,,,,,Lancet,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,News item or lay press,,,No,Yes,551,,
552,"Vogel, Science, 2016",Vogel,"Vogel, G.",A race to explain Brazil's spike in birth defects : Evidence points toward the fast-spreading Zika virus as the cause of microcephaly,Science,351,6269,110-111,2016,2010-present,,20160185382,http://dx.doi.org/10.1126/science.351.6269.110,1516,English,http://science.sciencemag.org/content/351/6269/110,,,,,,"amnion fluid, Brazil, congenital malformation/ep [Epidemiology], congenital malformation/et [Etiology], female, fetus development, human, immune response, learning disorder, microcephaly/cn [Congenital Disorder], microcephaly/ep [Epidemiology], microcephaly/et [Etiology], motor performance, nonhuman, priority journal, short survey, umbilical cord blood, virus, zika virus, immunoglobulin M antibody","Brazil is facing a disturbing spike in a severe birth defect called microcephaly. Babies are born with heads that are far too small, a sign that the brain failed to fully develop. Doctors there have reported nearly 3000 cases since July 2015-more than 20 times the usual rate. Scientists are scrambling to understand what is going on. The leading theory so far is that the condition is caused by a little known mosquito-borne virus called Zika that surfaced in Brazil in March and is quickly spreading through Latin America. The news has prompted the government to declare a public health emergency; some doctors are recommending women not get pregnant until more is known. Researchers are trying to develop better diagnostic tests for the virus so they can track whether mothers of affected babies were infected during their pregnancies, and other groups are hoping to use stem cell models of the developing human brain to understand how the virus might affect fetal growth. Meanwhile, the virus is advancing fast. It surfaced in Colombia, Suriname, Guatemala, El Salvador, and Mexico in October and November; Puerto Rico reported its first cases in late December. Researchers warn that countries across the Americas should be prepared for a similar wave of birth defects in coming months.",Embase,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,552,,
553,"Dowall, PLoS Negl Trop Dis, 2016",Dowall,"Dowall, Stuart D; Graham, Victoria A, Rayner, Emma, Atkinson, Barry, Hall, Graham, Watson, Robert J, Bosworth, Andrew, Bonney, Laura C, Kitchen, Samantha, Hewson, Roger",A susceptible mouse model for Zika virus infection,PLoS Negl Trop Dis,10,5,e0004658,2016,2010-present,,,10.1101/042358,1937,,http://www.ncbi.nlm.nih.gov/pubmed/27149521,,United Kingdom,Europe,United Kingdom,Public/Government,,"Zika virus (ZIKV) is a mosquito-borne pathogen which has recently spread beyond Africa and into Pacific and South American regions. Despite first being detected in 1947, very little information is known about the virus and its spread has been associated with increases in Guillain-Barre syndrome and microcephaly. There are currently no known vaccines or antivirals against ZIKV infection. Progress in assessing interventions will require the development of animal models to test efficacies; however, there are only limited reports on in vivo studies. The only susceptible murine models have involved intracerebral inoculations or juvenile animals, which do not replicate natural infection. Our report has studied the effect of ZIKV infection in type-I interferon receptor deficient (A129) mice and the parent strain (129Sv/Ev) after subcutaneous challenge in the lower leg to mimic a mosquito bite. A129 mice developed severe symptoms with viral RNA being detected widespread in the blood, brain, spleen, liver and ovaries. Histological changes were also striking in these animals. 129Sv/Ev mice developed no clinical symptoms or histological changes, despite viral RNA being detectable in the blood, spleen and ovaries, albeit at lower levels to those seen in A129 mice. Our results identify A129 mice as being highly susceptible to ZIKV and thus a suitable small animal model for the testing of vaccines and antivirals which are urgently required.",BiorXiv,March 31, 2016,Yes,,Yes,,Scientific (journal) article,No,Original research,No,Yes,553,Basic and applied biomedical research,Animal experiment
554,"Kohl, bioRxiv, 2016",Kohl,"Kohl, Alain; Pondeville, Emilie; Schnettler, Esther; Crisanti, Andrea; Supparo, Clelia; Christophides, George K.; Kersey, Paul J.; Maslen, Gareth L.; Takken, Willem; Koenraadt, Constantianus J. M.; Oliva, Clelia F.; Busquets, Núria; Abad, F. Xavier; Failloux, Anna-Bella; Levashina, Elena A.; Wilson, Anthony J.; Veronesi, Eva; Pichard, Maëlle; Marsh, Sarah Arnaud; Simard, Frédéric; Vernick, Kenneth D.","Advancing insect vector biology research: a community survey for future directions, research applications and infrastructure requirements",bioRxiv,,,,2016,2010-present,,,10.1101/042242,1938,,http://biorxiv.org/content/biorxiv/early/2016/03/03/042242.full.pdf,,,,,,,"Background: Vector-borne pathogens impact public health and economies worldwide. It has long been recognized that research on arthropod vectors such as mosquitoes, ticks, sandflies and midges which transmit parasites and arboviruses to humans and economically important animals is crucial for development of new control measures that target transmission by the vector. While insecticides are an important part of this arsenal, appearance of resistance mechanisms is an increasing issue. Novel tools for genetic manipulation of vectors, use of Wolbachia endosymbiotic bacteria and other biological control mechanisms to prevent pathogen transmission have led to promising new intervention strategies. This has increased interest in vector biology and genetics as well as vector-pathogen interactions. Vector research is therefore at a crucial juncture, and strategic decisions on future research directions and research infrastructures will benefit from community input. Methodology/Principal Findings: A survey initiated by the European Horizon2020 INFRAVEC-2 consortium set out to canvass priorities in the vector biology research community and to determine key issues that should be addressed for researchers to efficiently study vectors, vector-pathogen interactions, as well as access the structures and services that allow such work to be carried out. Conclusions/Significance: We summarize the key findings of the survey which in particular reflect priorities in European countries, and which will be of use to stakeholders that include researchers, government, and research organizations.",BiorXiv,March 31, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,No,Comment/Editorial/Perspective/Letter,No,Yes,554,,
555,"Carlson, bioRxiv, 2016",Carlson,"Carlson, Colin; Dougherty, Eric; Getz, Wayne",An ecological assessment of the pandemic threat of Zika virus,bioRxiv,,,,2016,2010-present,,,10.1101/040386,1943,,http://biorxiv.org/content/biorxiv/early/2016/03/09/040386.full.pdf,,,,,,,"The current outbreak of Zika virus poses a threat of unknown magnitude to human health. While the range of the virus has been cataloged growing slowly over the last 50 years, the recent explosive expansion in the Americas indicates that the full potential distribution of Zika remains uncertain. Moreover, most current epidemiology relies on its similarities to dengue fever, a phylogenetically closely related disease of unknown similarity in spatial range or ecological niche. Here we compile the first spatially explicit global occurrence dataset from Zika viral surveillance and serological surveys, and construct ecological niche models to test basic hypotheses about its spread and potential establishment. The hypothesis that the outbreak of cases in Mexico and North America are anomalous and outside the ecological niche of the disease, and may be linked to El Nino or similar climatic events, remains plausible at this time. Comparison of the Zika niche against the known distribution of dengue fever suggests that Zika is more constrained by the seasonality of precipitation and diurnal temperature fluctuations, likely confining the disease to the tropics outside of pandemic scenarios. Projecting the range of the diseases in conjunction with vector species (Aedes africanus, Ae. aegypti, and Ae. albopictus) that transmit the pathogens, under climate change, suggests that Zika has potential for northward expansion; but, based on current knowledge, Zika is unlikely to fill the full range its vectors occupy. With recent sexual transmission of the virus known to have occurred in the United States, we caution that our results only apply to the vector-borne aspect of the disease, and while the threat of a mosquito-carried Zika pandemic may be overstated in the media, other transmission modes of the virus may emerge and facilitate naturalization worldwide.",BiorXiv,March 31, 2016,Yes,,No,"Zika, not relevant to causality framework",Scientific (journal) article,No,Review,No,Yes,555,Clinical/epidemiological research,Modelling study
556,"Homan, bioRxiv, 2016",Homan,"Homan, Jane; Malone, Robert W.; Darnell, Steven J.; Bremel, Robert D.",Antibody mediated epitope mimicry in the pathogenesis of Zika virus related disease,bioRxiv,,,,2016,2010-present,,,10.1101/044834,1934,,http://biorxiv.org/content/biorxiv/early/2016/03/19/044834.full.pdf,,United States,Americas,United States,No funding received,,"The association of Guillain-Barré syndrome with Zika virus infection raises suspicion of autoimmunity in the pathogenesis of Zika associated disease. Using computational analysis to identify predicted B and T cell epitopes, we assessed whether antibodies elicited by B cell epitopes in Zika virus may also target B cell epitopes in the human proteome. We detected amino acid motifs predicted to be B cell epitopes in Zika virus proteins which are also present in human proteins, including pro-neuropeptide Y (proNPY), NAV2 and other proteins with interacting neurophysiologic function. We examine the predicted MHC binding of peptides likely to provide T cell help to the potential mimic epitopes. Some potential mimic epitopes in Zika virus envelope have apparently strong T cell help, likely facilitating immunoglobulin class switch. We also identify epitope mimic commonalities with dengue serotypes 1 and 3. We hypothesize that antibodies to Zika virus epitopes may contribute to the pathogenesis of Zika-associated Guillain-Barré syndrome, microcephaly, and ocular lesions, and may be a driver of autoimmunity. The risk associated with responses to potential epitope mimics must be addressed in the development of vaccines and therapeutics for Zika virus infections.",BiorXiv,March 31, 2016,Yes,,Yes,,Scientific (journal) article,No,Original research,No,Yes,556,Basic and applied biomedical research,Sequence analysis and phylogenetics
557,"Bhide, Bull World Health Organ, 2016",Bhide,"Bhide, Prajkta; Kar, Anita",Birth prevalence of microcephaly in India,Bull World Health Organ,,,,2016,2010-present,,,10.2471/blt.16.172080,1828,,,,,,,,,"Objective: To  derive  a  baseline  estimate  of  the  birth  prevalence  of  congenital  microcephaly  in   India, in the background of the suspected association with Zika virus infection. Methods: We  searched  Pubmed  and  Scopus  for identifying  studies  reporting  prevalence  of microcephaly  affected  births  in  India.  Only  nine  studies  reported  data  on  newborns  with microcephaly  among  both  live  and  stillbirths.  Pooled  prevalence  was  estimated  in  Review Manager (version 5.3) software using theinverse variance method.  Findings: The pooled prevalence rate of newborns with microcephaly was 2.30 per 10 000 births (95% CI 1.82 - 2.78) among 97 155 births reported by the nine studies. Conclusion: The  microcephaly  prevalence  rate  was  found  to  be  similar  to  that  reported  by  the European   surveillance   of   congenital   anomalies.   The need   for   clear   case   definition   of microcephaly  was  identified  in  order  to  limit  over-reporting  of  cases  due  to  diagnosis  based  on subjective evaluations.  ",WHO Zika open,March 31, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,No,Review,No,Yes,557,Clinical/epidemiological research,Epidemiological/clinical review
558,"Petersen, F1000Res, 2016",Petersen,"Petersen, L. R.; Powers, A. M.",Chikungunya: epidemiology,F1000Res,5,,,2016,2010-present,,26918158,10.12688/f1000research.7171.1,1837,,http://www.ncbi.nlm.nih.gov/pubmed/26918158,"Division of Vector-Borne Diseases, Centers for Disease Control and Prevention, Fort Collins, CO, USA.",,,,,Chikungunya; alphavirus; mosquito,"Chikungunya virus is a mosquito-borne alphavirus that causes fever and debilitating joint pains in humans. Joint pains may last months or years. It is vectored primarily by the tropical and sub-tropical mosquito, Aedes aegypti, but is also found to be transmitted by Aedes albopictus, a mosquito species that can also be found in more temperate climates. In recent years, the virus has risen from relative obscurity to become a global public health menace affecting millions of persons throughout the tropical and sub-tropical world and, as such, has also become a frequent cause of travel-associated febrile illness. In this review, we discuss our current understanding of the biological and sociological underpinnings of its emergence and its future global outlook.",F1000,March 31, 2016,No,Unrelated to Zika virus,,,Scientific (journal) article,Yes,Review,No,Yes,558,Clinical/epidemiological research,Epidemiological/clinical review
559,"Funk, bioRxiv, 2016",Funk,"Funk, Sebastian; Kucharski, Adam J.; Camacho, Anton; Eggo, Rosalind M.; Yakob, Laith; Edmunds, W. John",Comparative analysis of dengue and Zika outbreaks reveals differences by setting and virus,bioRxiv,,,,2016,2010-present,,,10.1101/043265,1935,,http://biorxiv.org/content/biorxiv/early/2016/03/24/043265.full.pdf,,,,,,,"The pacific islands of Micronesia have experienced several outbreaks of mosquito-borne diseases over the past decade. Since these outbreaks occurred in confined island populations, their analysis can improve our understanding of the transmission dynamics of the pathogens involved, and particularly so for yet understudied pathogens such as Zika virus. Here, we compare three outbreaks of dengue and Zika virus in two different island settings in Micronesia, the Yap Main Islands and Fais, using a mathematical model of transmission dynamics, making full use of commonalities in disease and setting between the outbreaks. We found that the estimated reproduction numbers for Zika and dengue are similar when considered in the same setting, but that, conversely, reproduction number for the same disease can vary considerably by setting. On the Yap Main Islands, we estimate a mean reproduction number of 4.3 (95% credible interval 3.1-6.1) for the dengue outbreak and 4.8 (2.9-8.1) for the Zika outbreak, whereas for the dengue outbreak on Fais our mean estimate is 10 (5.5-18). We further found that the ranges of most disease-specific parameters largely overlap between dengue and Zika, but that reporting rates of Zika cases are much smaller (3%, 1-7) than those of dengue (68%, 43-98). These results suggests that models for dengue transmission can be useful for estimating the predicted dynamics of Zika transmission, but care must be taken when extrapolating findings from one setting to another. Field studies on differences in vector density and biting exposure, as well as comparative modelling studies in other settings, could yield important further insights into the relationship between the transmission dynamics of Zika and dengue, and the specific setting in which they occur.",BiorXiv,March 31, 2016,Yes,,No,"Zika, not relevant to causality framework",Scientific (journal) article,No,Original research,No,Yes,559,Clinical/epidemiological research,Modelling study
560,"Dye, Bull World Health Organ, 2016",Dye,"Dye, C.; Bartolomeos, K.; Moorthy, V.; Kieny, M. P.",Data sharing in public health emergencies: a call to researchers,Bull World Health Organ,94,3,158,2016,2010-present,,26966322,10.2471/BLT.16.170860,1820,,http://www.ncbi.nlm.nih.gov/pubmed/26966322,"Department of Strategy, Policy & Information, World Health Organization, avenue Appia 20, Geneva 27, Switzerland .; Department of Immunization, Vaccines & Biologicals, World Health Organization, Geneva, Switzerland .; Health Systems and Innovation Cluster, World Health Organization, Geneva, Switzerland .",,,,,,,WHO Zika open,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,No,Comment/Editorial/Perspective/Letter,No,Yes,560,,
561,"Camacho, Emerg Infect Dis, 2016",Camacho,"Camacho, Erwin; Paternina-Gomez, Margaret; Blanco, Pedro J.; Osorio, Jorge E.; Aliota, Matthew T.","Detection of Autochthonous Zika Virus Transmission in Sincelejo, Colombia",Emerg Infect Dis,22,5,,2016,2010-present,,,10.3201/eid2205.160023,1905,,,,,,,,,,EID,March 31, 2016,Yes,,No,"Zika, indirect evidence or other topic",Scientific (journal) article,Yes,Original research,No,Yes,561,Basic and applied biomedical research,Sequence analysis and phylogenetics
562,"Poirier, Bull World Health Organ, 2016",Poirier,"Poirier, Mathieu J. P.; Moss, Delynn M.; Feeser, Karla R.; Streit, Thomas G.; Chang, Gwong-Jen J.; Whitney, Matthew; Russell, Brandy J.; Johnson, Barbara W.; Basile, Alison J.; Goodman, Christin H.; Barry, Amanda K.; Lammie, Patrick J.","Detection of immunoglobulin G responses in Haitian children exposed to chikungunya, dengue, and malaria using a multiplex bead assay",Bull World Health Organ,,,,2016,2010-present,,,10.2471/blt.16.173252,1829,,,,,,,,,"Objective: A solution to the challenge of differentiating the newly introduced pathogen of chikungunya virus (CHIKV) to Haiti in 2014 from endemic dengue virus (DENV) and other pathogens was sought. Methods: A multiplex bead assay (MBA) was used to detect immunoglobulin (Ig)G responses to one recombinant CHIKV envelope 1 antigen (CHIKV E1), two DENV virus-like particles (DENV-2 VLP and DENV-3 VLP), and three recombinant Plasmodium falciparum merozoite surface protein-1 antigens (MSP-1) using blood samp les collected longitudinally from 61 children from 2011 to 2014 and single blood spots collected from 127 children in 2014 in Leogane, Haiti. Findings: No IgG responses to CHIKV E1 antigen were observed from 2011 to 2013, but in 2014, the prevalence of positive IgG responses was 78.7%. The prevalence of CHIKV E1 responses was high and similar across all age groups; by contrast, the prevalence of responses in 2014 to DENV antigens increased steadily with age. Prevalence of positive IgG responses to the MSP-1 antigens was < 12%. Cluster analysis by Getis-Ord Gi Hot Spot Analysis showed increasing IgG responses to CHIKV E1 and DENV-2 VLP antigens in peri-urban areas compared to households situated closer to the sea shoreline. Conclusion: Serologic evidence documents the rapid and intense dissemination of CHIKV in Haiti. The MBA is an efficient and economical method to monitor the prevalence of exposures to multiple pathogens simultaneously. ",WHO Zika open,March 31, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,No,Original research,No,Yes,562,Clinical/epidemiological research,Cross-sectional study
563,"Rodríguez-Morales, Infectio, 2016",Rodríguez-Morales,"Rodríguez-Morales, Alfonso J.  Willamil-Gómez, Wilmer E.",El reto de Zika en Colombia y América Latina: Una urgencia sanitaria internacional,Infectio,20,2,59-61,2016,2010-present,,20160198848,10.1016/j.infect.2016.02.001,1502,Spanish,"http://www.elsevier.com/journals/infectio/0123-9392, http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emed13&AN=20160198848","(Rodriguez-Morales) Investigador Senior, Grupo de Investigacion Salud Publica e Infeccion, Facultad de Ciencias de la Salud, Universidad Tecnologica de Pereira, Pereira, Colombia (Rodriguez-Morales) Edit. Asociado, Infectio, Colombia (Rodriguez-Morales, Willamil-Gomez) Miembro Del Comite de Zoonosis y Fiebres Hemorragicas, Asociacion Colombiana de Infectologia, Colombia (Rodriguez-Morales, Willamil-Gomez) Comite de Medicina Del Viajero, Asociacion Panamericana de Infectologia, Colombia (Willamil-Gomez) Direc. de Investigacion, Hospital Universitario de Sincelejo, Sincelejo, Sucre, Colombia (Willamil-Gomez) Programa de Doctorado en Medicina Tropical, Universidad de Cartagena, Universidad Del Atlantico, Barranquilla, Colombia, A.J. Rodriguez-Morales, Investigador Senior, Grupo de Investigacion Salud Publica e Infeccion, Facultad de Ciencias de la Salud, Universidad Tecnologica de Pereira, Pereira, Colombia. E-mail: arodriguezm@utp.edu.co",,,,,"Colombia, editorial, South and Central America, virus, zika virus",,Embase,March 31, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,563,,
564,"InVS, , 2016",InVS,InVS,Point épidémio: Emergence du virus zika aux Antilles Guyane : Situation épidémiologique - 4 février 2016,,,,,2016,2010-present,,,,1890,,,,France,Europe,,Public/Government,,,Institute de veille sanitaire,March 31, 2016,Yes,,No,"Zika, indirect evidence or other topic",Surveillance report or data,,,No,Yes,564,Clinical/epidemiological research,Ecological study/outbreak report
565,"PAHO, Epidemiological Update. Neurological syndrome, congenital anomalies, and Zika virus infection - 17 January 2016. , 2016",PAHO,PAHO,"Epidemiological Update. Neurological syndrome, congenital anomalies, and Zika virus infection - 17 January 2016. ",,"Epidemiological Update. Neurological syndrome, congenital anomalies, and Zika virus infection - 17 January 2016. ",,,2016,2010-present,,,,1856,,http://www.paho.org/hq/index.php?option=com_docman&task=doc_view&Itemid=270&gid=32879&lang=en,,United States,Americas,,Public/Government,,,PAHO,March 31, 2016,Yes,,Yes,,Surveillance report or data,,,No,Yes,565,Clinical/epidemiological research,Case series
566,"PAHO, Epidemiological update. Zika virus infection - 31 March 2016, 2016",PAHO,PAHO,Epidemiological update. Zika virus infection - 31 March 2016,,Epidemiological update. Zika virus infection - 31 March 2016,,,2016,2010-present,,,,1863,,http://www.paho.org/hq/index.php?option=com_docman&task=doc_view&Itemid=270&gid=33659&lang=en,,United States,Americas,,Public/Government,,,PAHO,March 31, 2016,Yes,,Yes,,Surveillance report or data,,,No,Yes,566,Clinical/epidemiological research,Ecological study/outbreak report
567,"PAHO, Epidemiological update. Zika virus infection - 3 March 2016 and 17 March 2016, 2016",PAHO,PAHO,Epidemiological update. Zika virus infection - 3 March 2016 and 17 March 2016,,Epidemiological update. Zika virus infection - 3 March 2016 and 17 March 2016,,,2016,2010-present,,,,1858,,http://www.paho.org/hq/index.php?option=com_docman&task=doc_view&Itemid=270&gid=33296&lang=en,,United States,Americas,,Public/Government,,,PAHO,March 31, 2016,Yes,,Yes,,Surveillance report or data,,,No,Yes,567,Clinical/epidemiological research,Case series
568,"PAHO, Epidemiological update - 24 March 2016, 8 April 2016 and 28 April 2016, 2016",PAHO,PAHO,"Epidemiological update - 24 March 2016, 8 April 2016 and 28 April 2016",,"Epidemiological update - 24 March 2016, 8 April 2016 and 28 April 2016",,,2016,2010-present,,,,1864,,http://www.paho.org/hq/index.php?option=com_docman&task=doc_view&Itemid=270&gid=33768&lang=en,,United States,Americas,,Public/Government,,,PAHO,March 31, 2016,Yes,,Yes,,Surveillance report or data,,,No,Yes,568,Clinical/epidemiological research,Case series
569,"PAHO, Epidemiological update 21 April 2016, 2016",PAHO,PAHO,Epidemiological update 21 April 2016,,Epidemiological update 21 April 2016,,,2016,2010-present,,,,1859,,http://www.paho.org/hq/index.php?option=com_docman&task=doc_view&Itemid=270&gid=33372&lang=en,,United States,Americas,,Public/Government,,,PAHO,March 31, 2016,Yes,,Yes,,Surveillance report or data,,,No,Yes,569,Clinical/epidemiological research,Ecological study/outbreak report
570,"PAHO, Epidemiological update 24 March 2016, 2016",PAHO,PAHO,Epidemiological update 24 March 2016,,Epidemiological update 24 March 2016,,,2016,2010-present,,,,1862,,http://www.paho.org/hq/index.php?option=com_docman&task=doc_view&Itemid=270&gid=33937&lang=en,,United States,Americas,,Public/Government,,,PAHO,March 31, 2016,Yes,,No,"Zika, indirect evidence or other topic",Surveillance report or data,,,No,Yes,570,Clinical/epidemiological research,Case series
571,"PAHO, Epidemiological update 21 April 2016, 2016",PAHO,PAHO,Epidemiological update 21 April 2016,,Epidemiological update 21 April 2016,,,2016,2010-present,,,,1865,,http://www.paho.org/hq/index.php?option=com_docman&task=doc_view&Itemid=270&gid=33486&lang=en,,United States,Americas,,Public/Government,,,PAHO,March 31, 2016,Yes,,Yes,,Surveillance report or data,,,No,Yes,571,Clinical/epidemiological research,Ecological study/outbreak report
572,"ECDC, , 2016",ECDC,ECDC,Epidemiological update. Evolution of the Zika virus global outbreaks and complications potentially linked to the Zika virus outbreaks - 4 March 2016,,,,,2016,2010-present,,,,1857,,,,Sweden,Europe,,Public/Government,,,ECDC,March 31, 2016,Yes,,No,"Zika, indirect evidence or other topic",Surveillance report or data,,,No,Yes,572,Clinical/epidemiological research,Ecological study/outbreak report
573,"ECDC, , 2016",ECDC,ECDC,Epidemiological update. Outbreaks of Zika virus and complication potentially linked to the Zika virus infection - 24 March 2016,,,,,2016,2010-present,,,,1876,,,,Sweden,Europe,,Public/Government,,,ECDC,March 31, 2016,Yes,,No,"Zika, indirect evidence or other topic",Surveillance report or data,,,No,Yes,573,Clinical/epidemiological research,Ecological study/outbreak report
574,"ECDC, , 2016",ECDC,ECDC,Epidemiological update. Outbreaks of Zika virus and complications potentially linked to the Zika virus infection - 10 March 2016,,,,,2016,2010-present,,,,1874,,,,Sweden,Europe,,Public/Government,,,ECDC,March 31, 2016,Yes,,No,"Zika, indirect evidence or other topic",Surveillance report or data,,,No,Yes,574,Clinical/epidemiological research,Ecological study/outbreak report
575,"ECDC, , 2016",ECDC,ECDC,Epidemiological update. Outbreaks of Zika virus and complications potentially linked to the Zika virus infection - 12 February 2016,,,,,2016,2010-present,,,,1883,,,,Sweden,Europe,,Public/Government,,,ECDC,March 31, 2016,Yes,,No,"Zika, indirect evidence or other topic",Surveillance report or data,,,No,Yes,575,Clinical/epidemiological research,Ecological study/outbreak report
576,"ECDC, , 2016",ECDC,ECDC,Epidemiological update. Outbreaks of Zika virus and complications potentially linked to the Zika virus infection - 19 February 2016,,,,,2016,2010-present,,,,1879,,,,Sweden,Europe,,Public/Government,,,ECDC,March 31, 2016,Yes,,No,"Zika, indirect evidence or other topic",Surveillance report or data,,,No,Yes,576,Clinical/epidemiological research,Ecological study/outbreak report
577,"ECDC, , 2016",ECDC,ECDC,Epidemiological update. Outbreaks of Zika virus and complications potentially linked to the Zika virus infection - 26 February 2016,,,,,2016,2010-present,,,,1880,,,,Sweden,Europe,,Public/Government,,,ECDC,March 31, 2016,Yes,,No,"Zika, indirect evidence or other topic",Surveillance report or data,,,No,Yes,577,Clinical/epidemiological research,Ecological study/outbreak report
578,"ECDC, , 2016",ECDC,ECDC,Epidemiological update. Outbreaks of Zika virus and complications potentially linked to the Zika virus infection - 29 January 2016,,,,,2016,2010-present,,,,1881,,,,Sweden,Europe,,Public/Government,,,ECDC,March 31, 2016,Yes,,No,"Zika, indirect evidence or other topic",Surveillance report or data,,,No,Yes,578,Clinical/epidemiological research,Ecological study/outbreak report
579,"ECDC, , 2016",ECDC,ECDC,Epidemiological update. Outbreaks of Zika virus and complications potentially linked to the Zika virus infection - 5 February 2016,,,,,2016,2010-present,,,,1885,,,,Sweden,Europe,,Public/Government,,,ECDC,March 31, 2016,Yes,,No,"Zika, indirect evidence or other topic",Surveillance report or data,,,No,Yes,579,Clinical/epidemiological research,Ecological study/outbreak report
580,"PAHO, Epidemiological Update 24 March 2016, 2016",PAHO,PAHO,Epidemiological Update 24 March 2016,,Epidemiological Update 24 March 2016,,,2016,2010-present,,,,1878,,http://www.paho.org/hq/index.php?option=com_content&view=article&id=11675&Itemid=41711&lang=en,,United States,Americas,,Public/Government,,,PAHO,March 31, 2016,Yes,,Yes,,Surveillance report or data,,,No,Yes,580,Clinical/epidemiological research,Ecological study/outbreak report
581,"[No authors listed], Nature, 2016",[No authors listed],[No authors listed],Erratum: Scientists probe Zika link to birth defects (Nature (2016) 530 (142-143)),Nature,530,7591,395,2016,2010-present,,20160178227,http://dx.doi.org/10.1038/530395a,1522,English,"http://www.nature.com/nature/index.html, http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emed13&AN=20160178227",,,,,,"erratum, error",,Embase,March 31, 2016,No,Duplicate of existing record,,,,,,,,,,
582,"Roa, Lancet, 2016",Roa,"Roa, M.",Erratum: Zika virus outbreak: Reproductive health and rights in Latin America (The Lancet (2016) 387 (843)),Lancet,387,10021,848,2016,2010-present,,20160189636,http://dx.doi.org/10.1016/S0140-6736%2816%2900391-3,1512,English,"http://www.journals.elsevier.com/the-lancet/, http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emed13&AN=20160189636",,,,,,"erratum, error",,Embase,March 31, 2016,No,Duplicate of existing record,,,,,,,,,,
583,"Simmins, Bull World Health Organ, 2016",Simmins,"Simmins, Charles H.",Establishing base levels of microcephaly in Brazil prior to the arrival of Zika viral illnesses,Bull World Health Organ,,,,2016,2010-present,,,10.2471/blt.16.171223,1823,,,,,,,,,,WHO Zika open,March 31, 2016,Yes,,No,"Zika, indirect evidence or other topic",Scientific (journal) article,No,Review,No,Yes,583,Clinical/epidemiological research,Epidemiological/clinical review
584,"Majumder, Bull World Health Organ, 2016",Majumder,"Majumder, Maimuna S.; Cohn, Emily; Fish, Durland; Brownstein, John S.",Estimating a feasible serial interval range for Zika fever,Bull World Health Organ,,,,2016,2010-present,,,10.2471/blt.16.171009,1824,,,,,,,,,,WHO Zika open,March 31, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,No,Original research,No,Yes,584,Clinical/epidemiological research,Modelling study
585,"Eurosurveillance Editorial Team, Eurosurveillance, 2016",Eurosurveillance Editorial Team,Eurosurveillance Editorial Team,"European Commission Horizon 2020 programme call for vaccine development research into malaria and neglected infectious diseases, including Zika virus",Eurosurveillance,21,6,19-19,2016,2010-present,,370000000000,10.2807/1560-7917.Es.2016.21.6.30132,1553,English,<Go to ISI>://:000370332500005,"European Ctr Dis Prevent & Control ECDC, Stockholm, Sweden",,,,,"diarrhea, drug design, Flaviviridae, health care cost, health program, Horizon 2020, human, malaria, medical research, microcephaly, nonhuman, note, vaccine failure, virus infection, world health organization, zika virus, Zika virus infection",,Embase,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,585,,
586,"Cunha, Bull World Health Organ, 2016",Cunha,"Cunha, Antonio J. L. A.; Magalhães-Barbosa, Maria Clara; Lima-Setta, Fernanda; Prata-Barbosa, Arnaldo",Evolution of cases of microcephaly and neurological abnormalities suggestive of congenital infection in Brazil: 2015-2016,Bull World Health Organ,,,,2016,2010-present,March 16, 2016,,10.2471/blt.16.173583,1830,English,http://dx.doi.org/10.2471/BLT.16.173583,"Faculdade de Medicina, Universidade Federal do Rio de Janeiro, Av. Carlos Chagas Filho,  373, Edifício do Centro de Ciências da Saúde, Bloco K, 2º andar, Cidade Universitária, Ilha do  Fundão, 21.941-902 Rio de Janeiro, Brazil",Brazil,Americas,Brazil,Not reported/unknown,"microcephaly, congenital abnormalities, Zika virus","Objective: To  describe  the  evolution  of   cases  of  microcephaly and  neurological abnormalities suggestive of congenital infection in Brazil in 2015-2016. Methods : Analysis  of  secondary  epidemiological  data,  published  by  the  Brazilian Ministry  of  Health, to  monitor  the  epidemic  by  Zika virus.  Cases  of  microcephaly classified   as   notified,   confirmed,   excluded,   under investigation,   and   Zika   virus-associated  were  studied,  as  well  as  their  temporal evolution.  The  data  are  presented  in absolute  numbers,  percentages  and  prevalence  rates. The  excluded  to  confirmed  ratio, the increment rate and the percentage of confirmed cases were calculated. Findings: Until March 2016, the number of cases of microcephaly and/or abnormalities of the central nervous system being investigated in Brazil (n=4231) was almost 6 times the  number  of  confirmed  cases  (n=745);  these  745  were  approximately  one-third  of  those  who  concluded  the  investigation  (confirmed+ex cluded=1927).  The  number  of confirmed  cases  associated  to  Zika  virus  was  small (n=88).  Most  of  the  notified  and confirmed  cases  occurred  in  the  northeastern  region,  where  the  state  of  Pernambuco, Paraíba and Rio Grande do Norte showed the largest prevalence. A marked increase in the  notified  cases  (58.2%),  confirmed  cases (223.9%),  and  Zika  virus  associated  cases (> 14x) occurred in 2016. Conclusions: The  epidemic  of  microcephaly  and  neurological  abnormalities  associated with the Zika virus in Brazil is not declining and control measures should be intensified. In the light of the vast potential for spread of this virus, the knowledge of what occurs in Brazil may contribute to health actions in other places",WHO Zika open,March 31, 2016,Yes,,No,"Zika, indirect evidence or other topic",Scientific (journal) article,No,Original research,Yes,No,912,Clinical/epidemiological research,Ecological study/outbreak report
587,"Pylro, bioRxiv, 2016",Pylro,"Pylro, Victor; Oliveira, Francislon; Morais, Daniel; Orellana, Sara; Pais, Fabiano; Medeiros, Julliane; Geraldo, Juliana; Gilbert, Jack; Volpini, Angela; Fernandes, Gabriel",Exploring miRNAs as the key to understand symptoms induced by ZIKA virus infection through a collaborative database,bioRxiv,,,,2016,2010-present,,,10.1101/042382,1936,,http://biorxiv.org/content/biorxiv/early/2016/03/06/042382.full.pdf,,Brazil,Americas,Brazil,Not reported/unknown,,"In early 2015, a ZIKA Virus (ZIKV) infection outbreak was recognized in northeast Brazil, where concerns over its possible links with infant microcephaly have been discussed. Providing a definitive link between ZIKV infection and birth defects is still a big challenge. MicroRNAs (miRNAs), are small noncoding RNAs that regulating post-transcriptional gene expression by translational repression, and play important roles in viral pathogenesis and brain development. The potential for flavivirus-mediated miRNA signaling dysfunction in brain-tissue develop provides a compelling mechanism underlying perceived linked between ZIKV and microcephaly. Here, we provide novel evidences toward to understand the mechanism in which miRNAs can be linked to the congenital ZIKA syndrome symptoms. Moreover, following World Health Organization (WHO) recommendations, we have assembled a database to help target mechanistic investigations of this possible relationship between ZIKV symptoms and miRNA mediated human gene expression, helping to foster potential targets for therapy.",BiorXiv,March 31, 2016,Yes,,Yes,,Scientific (journal) article,No,Original research,No,Yes,587,Basic and applied biomedical research,Sequence analysis and phylogenetics
588,"Arzuza-Ortega, Emerg Infect Dis, 2016",Arzuza-Ortega,"Arzuza-Ortega, Laura; Polo, Arnulfo; Pérez-Tatis, Giamina; López-García, Humberto; Parra, Edgar; Pardo-Herrera, Lissethe C.; Rico-Turca, Angélica M.; Villamil-Gómez, Wilmer; Rodríguez-Morales, Alfonso J.","Fatal Zika Virus Infection in Girl with Sickle Cell Disease, Colombia",Emerg Infect Dis,22,5,,2016,2010-present,,,10.3201/eid2205.151934,1907,,,,,,,,,,EID,March 31, 2016,Yes,,No,"Zika, not relevant to causality framework",Scientific (journal) article,Yes,Original research,No,Yes,588,Clinical/epidemiological research,Case report
589,"Hassan, bioRxiv, 2016",Hassan,"Hassan, Yasser S.; Ogg, Sherry L.",Gene cloning and construction of prokaryotic and plant expression vectors of RICIN-A-Chain/PAP-S1 fusion protein and its inhibition of protein synthesis,bioRxiv,,,,2016,2010-present,,,10.1101/046060,1931,,http://biorxiv.org/content/biorxiv/early/2016/03/28/046060.full.pdf,,,,,,,"Pokeweed antiviral protein (PAP) is a single-chain ribosome-inactivating protein that exists in several forms isolated from various organs and at different stages of development of Phytolacca americana (pokeweed). In this study, PAP-S1, one of the two known isoforms found in seeds, was isolated and PCR amplified using primers based on the known mRNA of PAP-S2, the other known form found in seeds. The complete cDNA encoding PAP-S1 was determined here for the first time. PAP-S1 is a potent antiviral protein with many potential clinical applications. However, it was found to be dosage dependent with observed side effects at high dosage. In this study, we report the production of a recombinant antiviral peptide-fusion protein between Ricin A-chain and PAP-S1. The peptide-fusion recombinant proteins Ricin-A-Chain/PAP-S1 and PAP-S1/Ricin-A-Chain were generated by joining the N-terminus of PAP-S1 to the C-terminus of Ricin A-chain and the C-terminus of PAP-S1 to the N-terminus of Ricin A-chain respectively, and were expressed in an Escherichia coli cell free expression systems. The peptide-fusion recombinant protein Ricin-A-Chain/PAP-S1 (F2) was found to be more active than the PAP-S1/Ricin-A-chain (F1) and similar to PAP-S1 in a cell free prokaryotic environment (in this order of activity PAP-S1>F2>F1), and both showed much stronger activity in a cell free eukaryotic environment. The DNA sequence of the complete cDNA of PAP-S1 and of the peptide-fusion protein Ricin-A-Chain/PAP-S1 with the PAP-S1 signal peptide at the N-terminus of Ricin A-chain were inserted in plant destination binary vectors for A. tumefaciens mediated transformation. It is the opinion of the authors that additional research should be done in order to determine both cytotoxicity and selectivity of fusion protein F2 compared to PAP-S1, as it could be a viable, more potent and less cytotoxic alternative to PAP-S1 alone at high dosage, for both agricultural and therapeutic applications. Keywords: N-glycosidase, Phytolacca americana, antiviral protein, Pokeweed antiviral protein, Pokeweed antiviral protein from seeds, ribosome-inactivating protein, cDNA, Fusion protein, Inhibition of in vitro protein synthesis",BiorXiv,March 31, 2016,No,Unrelated to Zika virus,,,Scientific (journal) article,No,Original research,No,Yes,589,Basic and applied biomedical research,Other basic research
590,"Willison, Lancet, 2016",Willison,"Willison, H. J.; Jacobs, B. C.; van Doorn, P. A.",Guillain-Barre syndrome,Lancet,,,,2016,2010-present,,26948435,10.1016/S0140-6736(16)00339-1,1902,,http://www.ncbi.nlm.nih.gov/pubmed/26948435,"Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK. Electronic address: Hugh.Willison@glasgow.ac.uk.; Department of Neurology, Erasmus MC, University Medical Center, Rotterdam, Netherlands; Department of Immunology, Erasmus MC, University Medical Center, Rotterdam, Netherlands.; Department of Neurology, Erasmus MC, University Medical Center, Rotterdam, Netherlands.",,,,,,"Guillain-Barre syndrome is the most common and most severe acute paralytic neuropathy, with about 100 000 people developing the disorder every year worldwide. Under the umbrella term of Guillain-Barre syndrome are several recognisable variants with distinct clinical and pathological features. The severe, generalised manifestation of Guillain-Barre syndrome with respiratory failure affects 20-30% of cases. Treatment with intravenous immunoglobulin or plasma exchange is the optimal management approach, alongside supportive care. Understanding of the infectious triggers and immunological and pathological mechanisms has advanced substantially in the past 10 years, and is guiding clinical trials investigating new treatments. Investigators of large, worldwide, collaborative studies of the spectrum of Guillain-Barre syndrome are accruing data for clinical and biological databases to inform the development of outcome predictors and disease biomarkers. Such studies are transforming the clinical and scientific landscape of acute autoimmune neuropathies.",Lancet,March 31, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Review,No,Yes,590,Clinical/epidemiological research,Epidemiological/clinical review
591,"Ekins, F1000Res, 2016",Ekins,"Ekins, Sean; Liebler, John; Neves, Bruno J.; Lewis, Warren G.; Coffee, Megan; Bienstock, Rachelle; Southan, Christopher; Andrade, Carolina H.",Illustrating and homology modeling the proteins of the Zika virus,F1000Res,5,,275,2016,2010-present,,,10.12688/f1000research.8213.1,1834,,,,,,,,,"The Zika virus (ZIKV) is a flavivirus of the family Flaviviridae, which is similar to dengue virus, yellow fever and West Nile virus. Recent outbreaks in South America, Latin America, the Caribbean and in particular Brazil have led to concern for the spread of the disease and potential to cause Guillain-Barré syndrome and microcephaly. Although ZIKV has been known of for over 60 years there is very little in the way of knowledge of the virus with few publications and no crystal structures. No antivirals have been tested against it either in vitro or in vivo. ZIKV therefore epitomizes a neglected disease. Several suggested steps have been proposed which could be taken to initiate ZIKV antiviral drug discovery using both high throughput screens as well as structure-based design based on homology models for the key proteins. We now describe preliminary homology models created for NS5, FtsJ, NS4B, NS4A, HELICc, DEXDc, peptidase S7, NS2B, NS2A, NS1, E stem, glycoprotein M, propeptide, capsid and glycoprotein E using SWISS-MODEL. Eleven out of 15 models pass our criteria for selection. While a ZIKV glycoprotein E homology model was initially described in the immature conformation as a trimer, we now describe the mature dimer conformer which allowed the construction of an illustration of the complete virion. By comparing illustrations of ZIKV based on this new homology model and the dengue virus crystal structure we propose potential differences that could be exploited for antiviral and vaccine design. The prediction of sites for glycosylation on this protein may also be useful in this regard. While we await a cryo-EM structure of ZIKV and eventual crystal structures of the individual proteins, these homology models provide the community with a starting point for structure-based design of drugs and vaccines as well as a for computational virtual screening.",F1000,March 31, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,No,Original research,No,Yes,591,Basic and applied biomedical research,Other basic research
592,"Codeco, bioRxiv, 2016",Codeco,"Codeco, Claudia; Cruz, Oswaldo; Riback, Thais I.; Degener, Carolin M.; Gomes, Marcelo F.; Villela, Daniel; Bastos, Leonardo; Camargo, Sabrina; Saraceni, Valeria; Lemos, Maria Cristina F.; Coelho, Flavio C.",InfoDengue: a nowcasting system for the surveillance of dengue fever transmission,bioRxiv,,,,2016,2010-present,,,10.1101/046193,1930,,http://biorxiv.org/content/biorxiv/early/2016/03/29/046193.full.pdf,,,,,,,"This study describes the development of an integrated dengue alert system (InfoDengue), operating initially in the city of Rio de Janeiro, Brazil. It is a project developed as a partnership between academia and the municipal health secretariat. At the beginning of each epidemiological week, the system captures climate time series, dengue case reporting and activity on a social network. After data pre-processing, including a probabilistic correction of case notification delay, and calculation of dengue's effective reproductive number, indicators of dengue transmission are coded into four dengue situation levels, for each of the city's ten health districts. A risk map is generated to inform the public about the week's level of attention and the evolution of the disease incidence and suggest actions. A report is also sent automatically to the municipality's situation room, containing a detailed presentation of the data and alert levels by health district. The preliminary analysis of InfoDengue in Rio de Janeiro, using historical series from 2011 to 2014 and prospective data from January to December 2015, indicates good degree of confidence and accuracy. The successful experience in the city of Rio de Janeiro is a motivating argument for the expansion of InfoDengue to other cities. After a year in production, InfoDengue has become a unique source of carefully curated data for epidemiological studies, combining epidemological and environmental variables in unprecedented spatial and temporal resolutions.",BiorXiv,March 31, 2016,No,Unrelated to Zika virus,,,Scientific (journal) article,No,Original research,No,Yes,592,Clinical/epidemiological research,Other clinical/epidemiological
593,"Secretaria de Saúde do Estado de Pernambuco. Secretaria Executiva de Vigilância em Saúde. Brasil, , 2016",Secretaria de Saúde do Estado de Pernambuco. Secretaria Executiva de Vigilância em Saúde. Brasil,Secretaria de Saúde do Estado de Pernambuco. Secretaria Executiva de Vigilância em Saúde. Brasil,Informe Técnico: Possível alteração do padrão epidemiológico de microcefalia em Pernambuco / Technical Report: possible change in the epidemiological pattern of microcephaly in Pernambuco.,,,,,2016,2010-present,,,,1814,Portuguese,,,,,,,"Microcephaly/embryology, Microcephaly/epidemiology, Central Nervous System/abnormalities, Epidemiological Monitoring,  Stillbirth/epidemiology, Brazil/epidemiology, Humans, Infant, Newborn","A Secretaria Estadual de Saúde de Pernambuco -SES/PE, com o apoio do Ministério da Saúde, da Organização Pan-Americana de Saúde e das equipes de saúde envolvidas, está investigando uma possível alteração do padrão epidemiológico da microcefalia e os fatores associados a este evento no estado de Pernambuco. (AU)",LILACS,March 31, 2016,No,No full-text obtained yet,,,Surveillance report or data,,,No,Yes,593,Clinical/epidemiological research,Ecological study/outbreak report
594,"Ministério da Saúde. Centro de Operações de Emergência em Saúde. Brasil, , 2016",Ministério da Saúde. Centro de Operações de Emergência em Saúde. Brasil,Ministério da Saúde. Centro de Operações de Emergência em Saúde. Brasil,Informe epidemiológico nº 15 - semana epidemiológica (se) 08 /2016 (21 a 27 /02 /201 6) monitoramento dos casos de microcefalia no Brasil / Epidemiological report 15 - epidemiological week (if) 08/2016 (21-27 / 02/201 6) monitoring of cases of microcephaly in Brazil.,,,,,2016,2010-present,,,,1810,,,,,,,,,"Este documento constam as informações epidemiológicas referentes à microcefalia e/ou alterações do SNC, previstas nas definições vigentes no 'Protocolo de Vigilância e Resposta à Ocorrência de MicrocefaliaVersão 1.3/2016', disponível no site www.saude.gov.br/svs.",LILACS,March 31, 2016,No,No full-text obtained yet,,,Surveillance report or data,,,No,Yes,594,Clinical/epidemiological research,Ecological study/outbreak report
595,"Secretaria de Saúde do Estado de Pernambuco. Secretaria executiva de Vigilância em Saúde. Brasil, , 2016",Secretaria de Saúde do Estado de Pernambuco. Secretaria executiva de Vigilância em Saúde. Brasil,Secretaria de Saúde do Estado de Pernambuco. Secretaria executiva de Vigilância em Saúde. Brasil,Informe técnico: possível alteração do padrão epidemiológico de microcefalia em Pernambuco: informe técnico SEVS/SES-PE nº 24:gestantes com exantema / Technical report: possible change in the epidemiological pattern of microcephaly in Pernambuco: technical report SEVS / SES-PE # 24: Pregnant women with exanthema.,,,,,2016,2010-present,,,,1813,,,,,,,,,,LILACS,March 31, 2016,No,No full-text obtained yet,,,Surveillance report or data,,,No,Yes,595,Clinical/epidemiological research,Ecological study/outbreak report
596,"Bonaldo, bioRxiv, 2016",Bonaldo,"Bonaldo, Myrna C.; Ribeiro, Ieda P.; Lima, Noemia S.; Santos, Alexandre A. C.; Menezes, Lidiane S. R.; Cruz, Stephanie O. D.; Mello, Iasmim S.; Furtado, Nathália D.; Moura, Elaine E.; Damasceno, Luana; Silva, Keli A. B.; Castro, Marcia G.; Gerber, Alexandra L.; Almeida, Luiz G. P.; Lourenço-de-Oliveira, Ricardo; Vasconcelos, Ana Tereza R.; Brasil, Patrícia",Isolation of infective Zika virus from urine and saliva of patients in Brazil,bioRxiv,,,,2016,2010-present,,,10.1101/045443,1932,English,http://biorxiv.org/content/biorxiv/early/2016/03/24/045443.full.pdf,,,,,,,"Zika virus (ZIKV) is an emergent threat provoking a worldwide explosive outbreak. Since January 2015, 41 countries reported autochthonous cases. In Brazil, an increase in Guillain-Barré syndrome and microcephaly cases was linked to ZIKV infections. A recent report describing low experimental transmission efficiency of its main putative vector, Ae. aegypti, in conjunction with apparent sexual transmission notifications prompted the investigation of other potential sources of viral dissemination. Urine and saliva have been previously established as useful tools in ZIKV diagnosis. However, no evidence regarding the infectivity of ZIKV particles present in saliva and urine has been obtained yet. Nine urine and five saliva samples from nine patients from Rio de Janeiro presenting rash and other typical Zika acute phase symptoms were inoculated in Vero cell culture and submitted to specific ZIKV RNA detection and quantification through, respectively, NAT-Zika, RT-PCR and RT-qPCR. Two ZIKV isolates were achieved, one from urine and one from saliva specimens. ZIKV nucleic acid was identified by all methods in four patients. Whenever both urine and saliva samples were available from the same patient, urine viral loads were higher, corroborating the general sense that it is a better source for ZIKV molecular diagnostic. In spite of this, from the two isolated strains, each from one patient, only one derived from urine, suggesting that other factors, like the acidic nature of this fluid, might interfere with virion infectivity. The complete genome of both ZIKV isolates was obtained. Phylogenetic analysis revealed similarity with strains previously isolated during the South America outbreak. The detection of infectious ZIKV particles in urine and saliva of patients during the acute phase may represent a critical factor in the spread of virus. The epidemiological relevance of this finding, regarding the contribution of alternative non vectorial ZIKV transmission routes, needs further investigation.",BiorXiv,March 31, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,No,Original research,No,Yes,596,Basic and applied biomedical research,In vitro experiment
597,"Perkasa, Emerg Infect Dis, 2016",Perkasa,"Perkasa, Aditya; Yudhaputri, Frilasita; Haryanto, Sotianingsih; Hayati, Rahma F.; Ma'roef, Chairin Nisa; Antonjaya, Ungke; Yohan, Benediktus; Myint, Khin Saw Aye; Ledermann, Jeremy P.; Rosenberg, Ronald; Powers, Ann M.; Sasmono, R. Tedjo","Isolation of Zika Virus from Febrile Patient, Indonesia",Emerg Infect Dis,22,5,,2016,2010-present,,,10.3201/eid2205.151915,1908,English,,,,,,,,,EID,March 31, 2016,Yes,,No,"Zika, indirect evidence or other topic",Scientific (journal) article,Yes,Original research,No,Yes,597,Basic and applied biomedical research,Sequence analysis and phylogenetics
598,"Victora, Lancet, 2016",Victora,"Victora, Cesar Gomes; Schuler-Faccini, Lavinia; Matijasevich, Alicia; Ribeiro, Erlane; Pessoa, André; Barros, Fernando Celso",Microcephaly in Brazil: how to interpret reported numbers?,Lancet,387,10019,621-624,2016,2010-present,,,10.1016/s0140-6736(16)00273-7,1900,,,,,,,,,,Lancet,March 31, 2016,Yes,,No,"Zika, not relevant to causality framework",Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,598,,
599,"Juliana Sousa Soares de Araújo, Bull World Health Organ, 2016",Juliana Sousa Soares de Araújo,"Juliana Sousa Soares de Araújo, Cláudio Teixeira Regis, Renata Grigório Silva Gomes, Thiago Ribeiro Tavares, Cícera Rocha dos Santos, Patrícia Melo Assunção, Renata Valéria Nóbrega, Diana de Fátima Alves Pinto, Bruno Vinícius Dantas Bezerrab & Sandra  da Silva Mattosa",Microcephaly in northeastern Brazil: a review of 16 208 births between 2012 and 2015,Bull World Health Organ,,,,2016,2010-present,February 4, 2016,,10.2471/blt.16.170639,1821,English,http://www.who.int/bulletin/online_first/16-170639.pdf,"Av. Agamenon Magalhães  2760, Paissandu, Recife - Pernambuco - CEP 52010-902, Brazil,  ssmattos@cardiol.br",Brazil,Americas,Brazil,Not reported/unknown,,"A recent outbreak of microcephaly has been reported from Northeast Brazil. Neither its aetiology, nor its clinical significance has yet been fully established. A complication from an intrauterine infection with the Zika virus (ZIKV) is, thus far, the most explored hypothesis. In Paraíba, one of the nine States within the epicentre of the epidemic, 21 medical centres collaborate, via telemedicine since 2012, in a paediatric cardiology network. The Network's database currently stores information on more than 100,000 neonates. To support the microcephaly research, from December 1st to 31st, 2015, the Network ran a task force and rescued the head circumference from 16,208 neonates. A much higher than expected incidence of microcephaly was observed, varying from 2% to 8% according to the utilized classification criteria. These findings raise questions about the condition' s diagnosis and its notification. An observed presentation' s seasonality might reflect that of infections carried on by the Aedis aegypti vector. However, the temporal fluctuation was documented since late 2012, before the allegedly entry of the ZIKV in Brazil, in mid-2014. Further questions are raised on both the epidemiological surveillance of the Aedis aegypti infections, as well as on different aetiological possibilities for the outbreak. At this stage, follow-up studies in the children diagnosed with microcephaly are mandatory prior to concluding what problem we are facing; how it came about and which consequences it may, or not, bring to the Brazilian population in years to come.",WHO Zika open,March 31, 2016,Yes,,No,"Zika, indirect evidence or other topic",Scientific (journal) article,No,Original research,No,Yes,599,Clinical/epidemiological research,Cross-sectional study
600,"Rocha, Bull World Health Organ, 2016",Rocha,"Rocha, Hermano Alexandre Lima; Correia, Luciano Lima; Leite, Álvaro Jorge Madeiro; Campos, Jocileide Sales; Cavalcante e Silva, Anamaria; Machado, Márcia Maria Tavares; Rocha, Sabrina Gabriele Maia Oliveira; Saraiva de Almeida, Nádia Maria Girão; Alves da Cunha, Antonio José Ledo",Microcephaly: normality parameters and its determinants in northeastern Brazil: a multicentre prospective cohort study,Bull World Health Organ,,,,2016,2010-present,,,10.2471/blt.16.171215,1822,,,,,,,,,"Brazil was marked by a serious epidemic of microcep  haly due to still obscure causes. According to the Ministry of Health, the number of suspected cases of microcephaly reached 2401. However, there is controversy in Brazil regarding the most appropriate cut-off point and diagnosis criteria. The present study aimed to measure the prevalence of microcephaly and identify its determinants, in a prospective cohort from a multicentre hospital-based study. The sample comprised 3623 live births admitted to the NICU, the dependent variable being   cephalic perimeter. Bootstrap and logistic regressi  on models were used to analyse data. 32 cm   corresponded to tenth percentile in this population  , with a confidence interval between 31.82   and 32.18. Intrauterine growth restriction, pregnancies resulting in congenital anomalies,   oligohydramnios and the maternal use of steroids we  re associated with microcephaly. This work raises discussion on the cut-off point used for the diagnosis of microcephaly at a population level in a country with an outbreak as well as factors that can be associated with the outcome presented. ",WHO Zika open,March 31, 2016,Yes,,No,"Zika, not relevant to causality framework",Scientific (journal) article,No,Original research,No,Yes,600,Clinical/epidemiological research,Cohort study
601,"Perkins, bioRxiv, 2016",Perkins,"Perkins, Alex; Siraj, Amir; Warren Ruktanonchai, Corrine; Kraemer, Moritz; Tatem, Andrew",Model-based projections of Zika virus infections in childbearing women in the Americas,bioRxiv,,,,2016,2010-present,,,10.1101/039610,1947,,http://biorxiv.org/content/biorxiv/early/2016/02/12/039610.full.pdf,,,,,,,"Zika virus is a mosquito-borne pathogen that is rapidly spreading across the Americas. Due to a probable association between Zika virus infection and a congenital neurological disorder called microcephaly, the epidemic trajectory of this viral infection poses a significant concern for the nearly 15 million children born in the Americas each year. The potential magnitude of the ongoing Zika epidemic is exceedingly difficult to gauge based on existing data, due to a number of uncertainties that cloud the relationship between observed cases and true infections. As an alternative to methods that depend on unreliable case data, we developed and applied a new method that leverages highly spatially resolved data about drivers of Zika transmission to project that 1.1 (1.0-1.9) million infections in childbearing women and 64.2 (53.6-108.1) million infections across all demographic strata could occur before the first wave of the epidemic concludes. Our projection is largely consistent with annual, region-wide estimates of 53.8 (40.0-71.8) million infections by dengue virus, which has many similarities to Zika. Our projection is also consistent with state-level data from Brazil on confirmed, Zika-associated microcephaly cases, and it suggests that the current epidemic has the potential to negatively impact tens of thousands of pregnancies. These projections constitute an important early contribution to efforts to understand the potential magnitude of the Zika epidemic, and our methods offer a new way to make rapid assessments of the threat posed by emerging infectious diseases.",BiorXiv,March 31, 2016,Yes,,No,"Zika, indirect evidence or other topic",Scientific (journal) article,No,Original research,No,Yes,601,Clinical/epidemiological research,Modelling study
602,"Reich, Lancet, 2016",Reich,"Reich, M. R.; Harris, J.; Ikegami, N.; Maeda, A.; Cashin, C.; Araujo, E. C.; Takemi, K.; Evans, T. G.",Moving towards universal health coverage: lessons from 11 country studies,Lancet,387,10020,811-6,2016,2010-present,,26299185,10.1016/S0140-6736(15)60002-2,1896,,http://www.ncbi.nlm.nih.gov/pubmed/26299185,"Department of Global Health and Population, Harvard T.H. Chan School of Public Health, Boston, MA, USA.; Department of Sociology, Boston University, Boston, MA, USA.; Keio University, Tokyo, Japan.; Health, Nutrition and Population Global Practice, The World Bank, Washington, DC, USA. Electronic address: amaeda@worldbank.org.; Results for Development Institute, Washington, DC, USA.; Health, Nutrition and Population Global Practice, The World Bank, Washington, DC, USA.; House of Councillors, The National Diet of Japan, Tokyo, Japan.",,,,,Delivery of Health Care/economics/*organization & administration; Goals; Health Care Reform/*organization & administration; Healthcare Disparities; Healthcare Financing; Humans; Universal Coverage/economics/*organization & administration/trends,"In recent years, many countries have adopted universal health coverage (UHC) as a national aspiration. In response to increasing demand for a systematic assessment of global experiences with UHC, the Government of Japan and the World Bank collaborated on a 2-year multicountry research programme to analyse the processes of moving towards UHC. The programme included 11 countries (Bangladesh, Brazil, Ethiopia, France, Ghana, Indonesia, Japan, Peru, Thailand, Turkey, and Vietnam), representing diverse geographical, economic, and historical contexts. The study identified common challenges and opportunities and useful insights for how to move towards UHC. The study showed that UHC is a complex process, fraught with challenges, many possible pathways, and various pitfalls--but is also feasible and achievable. Movement towards UHC is a long-term policy engagement that needs both technical knowledge and political know-how. Technical solutions need to be accompanied by pragmatic and innovative strategies that address the national political economy context.",Lancet,March 31, 2016,No,Unrelated to Zika virus,,,Scientific (journal) article,Yes,Review,No,Yes,602,Clinical/epidemiological research,Other clinical/epidemiological
603,"Dudley, bioRxiv, 2016",Dudley,"Dudley, Dawn M.; Aliota, Matthew T.; Mohr, Emma L.; Weiler, Andrea M.; Lehrer-Brey, Gabrielle; Weisgrau, Kim L.; Mohns, Mariel S.; Breitbach, Meghan E.; Rasheed, Mustafa N.; Newman, Christina M.; Gellerup, Dane D.; Moncla, Louise H.; Post, Jennifer; Schultz-Darken, Nancy; Eudailey, Josh A.; Moody, M. Anthony; Permar, Sallie R.; O'Connor, Shelby L.; Rakasz, Eva G.; Simmons, Heather A.; Capuano, Saverio; Golos, Thaddeus G.; Osorio, Jorge E.; Friedrich, Thomas C.; O'Connor, David H.",Natural history of Asian lineage Zika virus infection in macaques,bioRxiv,,,,2016,2010-present,,,10.1101/046334,1929,English,http://biorxiv.org/content/biorxiv/early/2016/03/30/046334.full.pdf,,United States,Americas,United States,Public/Government,,"Infection with Asian lineage Zika virus has been associated with Guillain-Barré syndrome and fetal microcephaly 1-4. Here we show that rhesus macaques are susceptible to infection by an Asian lineage Zika virus isolate that shares more than 99% nucleotide identity with strains currently circulating in the Americas. Following subcutaneous inoculation, Zika virus RNA was detected in plasma one-day post infection (dpi) in all animals (N = 3). Plasma viral loads peaked above 1 x 106 viral RNA copies/mL in two of three animals. Viral RNA was also present in saliva, urine, and cerebrospinal fluid (CSF), consistent with case reports from infected humans. Zika virus RNA persisted in both plasma and urine at low levels for more than two weeks. Infection was associated with transient increases in proliferating natural killer cells, CD8+ and CD4+ T cells, and plasmablasts, suggesting pathogen sensing by the immune system. These data establish that Asian lineage Zika virus infection in rhesus macaques provides a relevant animal model for human infection. Furthermore, because fetal development is well characterized in rhesus macaques, infections in pregnant macaques will enable important studies of fetal defects associated with Zika virus.",BiorXiv,March 31, 2016,Yes,,Yes,,Scientific (journal) article,No,Original research,No,Yes,603,Basic and applied biomedical research,Animal experiment
604,"Horton, Lancet, 2016",Horton,"Horton, R.",Offline: Brazil-the unexpected opportunity that Zika presents,Lancet,387,10019,633-633,2016,2010-present,,370000000000,10.1016/S0140-6736(16)00268-3,1557,English,<Go to ISI>://:000369837100010,R. Horton,,,,,"Brazil, dengue, economic aspect, epidemic, government regulation, health care quality, human, note, political system, priority journal, virus, virus infection, world health organization, zika virus, Zika virus infection",,Embase,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,604,,
605,"Monaghan, PLoS Curr, 2016",Monaghan,"Monaghan, Andrew J.; Morin, Cory W.; Steinhoff, Daniel F.; Wilhelmi, Olga; Hayden, Mary; Quattrochi, Dale A.; Reiskind, Michael; Lloyd, Alun L.; Smith, Kirk; Schmidt, Chris A.; Scalf, Paige E.; Ernst, Kacey",On the Seasonal Occurrence and Abundance of the Zika Virus Vector Mosquito Aedes Aegypti in the Contiguous United States,PLoS Curr,,,,2016,2010-present,,,10.1371/currents.outbreaks.50dfc7f46798675fc63e7d7da563da76,1891,,,,,,,,,"Introduction: An ongoing Zika virus pandemic in Latin America and the Caribbean has raised concerns that travel-related introduction of Zika virus could initiate local transmission in the United States (U.S.) by its primary vector, the mosquito Aedes aegypti. Methods: We employed meteorologically driven models for 2006-2015 to simulate the potential seasonal abundance of adult Aedes aegypti for fifty cities within or near the margins of its known U.S. range. Mosquito abundance results were analyzed alongside travel and socioeconomic factors that are proxies of viral introduction and vulnerability to human-vector contact. Results: Meteorological conditions are largely unsuitable for Aedes aegypti over the U.S. during winter months (December-March), except in southern Florida and south Texas where comparatively warm conditions can sustain low-to-moderate potential mosquito abundance. Meteorological conditions are suitable for Aedes aegypti across all fifty cities during peak summer months (July-September), though the mosquito has not been documented in all cities. Simulations indicate the highest mosquito abundance occurs in the Southeast and south Texas where locally acquired cases of Aedes-transmitted viruses have been reported previously. Cities in southern Florida and south Texas are at the nexus of high seasonal suitability for Aedes aegypti and strong potential for travel-related virus introduction. Higher poverty rates in cities along the U.S.-Mexico border may correlate with factors that increase human exposure to Aedes aegypti. Discussion: Our results can inform baseline risk for local Zika virus transmission in the U.S. and the optimal timing of vector control activities, and underscore the need for enhanced surveillance for Aedes mosquitoes and Aedes-transmitted viruses.",PLoS,March 31, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Original research,No,Yes,605,Environmental and vector research,Ecological/vector modelling
606,"Ekins, F1000Res, 2016",Ekins,"Ekins, Sean; Mietchen, Daniel; Coffee, Megan; Stratton, Thomas; Freundlich, Joel; Freitas-Junior, Lucio; Muratov, Eugene; Siqueira-Neto, Jair; Williams, Antony; Andrade, Carolina",Open drug discovery for the Zika virus,F1000Res,,,,2016,2010-present,,,10.12688/f1000research.8013.1,1835,,,,,,,,,"The Zika virus (ZIKV) outbreak in the Americas has caused global concern that we may be on the brink of a healthcare crisis. The lack of research on ZIKV in the over 60 years that we have known about it has left us with little in the way of starting points for drug discovery. Our response can build on previous efforts with virus outbreaks and lean heavily on work done on other flaviviruses such as dengue virus. We provide some suggestions of what might be possible and propose an open drug discovery effort that mobilizes global science efforts and provides leadership, which thus far has been lacking. We also provide a listing of potential resources and molecules that could be prioritized for testing as in vitro assays for ZIKV are developed. We propose also that in order to incentivize drug discovery, a neglected disease priority review voucher should be available to those who successfully develop an FDA approved treatment. Learning from the response to the ZIKV, the approaches to drug discovery used and the success and failures will be critical for future infectious disease outbreaks.",F1000,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,606,,
607,"Lanciotti, Emerg Infect Dis, 2016",Lanciotti,"Lanciotti, Robert S., Lambert, Amy J., Holodniy, Mark, Saavedra, Sonia, Signor, Leticia del Carmen Castillo","Phylogeny of Zika Virus in Western Hemisphere, 2015",Emerg Infect Dis,22,,,2016,2010-present,,,10.3201/eid2205.160065,1904,,,,,,,,,,EID,March 31, 2016,Yes,,No,"Zika, indirect evidence or other topic",Scientific (journal) article,Yes,Original research,No,Yes,607,Basic and applied biomedical research,Sequence analysis and phylogenetics
608,"Veljkovic, F1000Res, 2016",Veljkovic,"Veljkovic, Veljko, Paessler, Slobodan",Possible repurposing of seasonal influenza vaccine for prevention of Zika virus infection,F1000Res,5,,190,2016,2010-present,,,10.12688/f1000research.8102.2,1831,,,,,,,,,"The in silico analysis shows that the envelope glycoproteins E of Zika viruses (ZIKV) isolated in Asia, Africa and South and Central America encode highly conserved information determining their interacting profile and immunological properties. Previously it was shown that the same information is encoded in the primary structure of the hemagglutinin subunit 1 (HA1) from pdmH1N1 influenza A virus.  This similarity suggests possible repurposing of the seasonal influenza vaccine containing pdmH1N1 component for prevention of the ZIKV infection.",F1000,March 31, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Original research,No,Yes,608,Basic and applied biomedical research,Sequence analysis and phylogenetics
609,"Rodriguez-Morales, F1000Res, 2016",Rodriguez-Morales,"Rodriguez-Morales, Alfonso J.; Gil-Restrepo, Andrés F.; Ramírez-Jaramillo, Valeria; Montoya-Arias, Cindy P.; Acevedo-Mendoza, Wilmer F.; Bedoya-Arias, Juan E.; Chica-Quintero, Laura A.; Murillo-García, David R.; García-Robledo, Juan E.; Castrillón-Spitia, Juan D.; Londoño, Jose J.; Bedoya-Rendón, Hector D.; Cárdenas-Pérez, Javier de Jesús; Cardona-Ospina, Jaime A.; Lagos-Grisales, Guillermo J.","Post-chikungunya chronic inflammatory rheumatism: results from a retrospective follow-up study of 283 adult and child cases in La Virginia, Risaralda, Colombia",F1000Res,5,,360,2016,2010-present,,,10.12688/f1000research.8235.1,1832,,,,,,,,,"Objective: There are limited studies in Latin America regarding the chronic consequences of the Chikungunya virus (CHIK), such as post-CHIK chronic inflammatory rheumatism (pCHIK-CIR). We assessed the largest cohort so far of pCHIK-CIR in Latin America, at the municipality of La Virginia, Risaralda, a new endemic area of CHIK in Colombia. Methods: We conducted a cohort retrospective study in Colombia of 283 patients diagnosed with CHIK that persisted with pCHIK-CIR after a minimum of 6 weeks and up to a maximum of 26.1 weeks. pCHIK cases were identified according to validated criteria via telephone. Results: Of the total CHIK-infected subjects, 152 (53.7%) reported persistent rheumatological symptoms (pCHIK-CIR). All of these patients reported joint pains (chronic polyarthralgia, pCHIK-CPA), 49.5% morning stiffness, 40.6% joint edema, and 16.6% joint redness. Of all patients, 19.4% required and attended for care prior to the current study assessment (1.4% consulting rheumatologists). Significant differences in the frequency were observed according to age groups and gender. Patients aged >40 years old required more medical attention (39.5%) than those ≤40 years-old (12.1%) (RR=4.748, 95%CI 2.550-8.840). Conclusions: According to our results, at least half of the patients with CHIK developed chronic rheumatologic sequelae, and from those with pCHIK-CPA, nearly half presented clinical symptoms consistent with inflammatory forms of the disease. These results support previous estimates obtained from pooled data of studies in La Reunion (France) and India and are consistent with the results published previously from other Colombian cohorts in Venadillo (Tolima) and Since (Sucre).",F1000,March 31, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Original research,No,Yes,609,Clinical/epidemiological research,Cohort study
610,"Rodriguez-Barraquer, bioRxiv, 2016",Rodriguez-Barraquer,"Rodriguez-Barraquer, Isabel, Salje, Henrik, Lessler, Justin, Cummings, Derek AT",Predicting intensities of Zika infection and microcephaly using transmission intensities of other arboviruses,bioRxiv,,,,2016,2010-present,,,10.1101/041095,1942,,http://biorxiv.org/content/biorxiv/early/2016/02/23/041095.full.pdf,,United States,Americas,United States,Public/Government,,"The World Health Organization has declared Zika Virus a Public Health Emergency of International Concern due to the virus' emergence in multiple countries globally and the possible association of Zika virus with microcephaly and neurological disorders. There is a clear need to identify risk factors associated with Zika infection and microcephaly in order to target surveillance, testing and intervention efforts. Here, we show that there is a strong correlation between the incidence of Zika in Colombian departments and the force of infection (but not the crude incidence) of dengue, a virus transmitted by the same mosquito species, Aedes aegypti (R2 = 0.41, p<0.001). Furthermore, we show that there is also a strong correlation between the incidence of microcephaly in Brazilian states and the force of infection of dengue (R2 = 0.36, p<0.001). Because dengue, Zika and Chikungunya are transmitted by the same vector, these associations provide further support to the supposition that Zika virus infection during pregnancy causes microcephaly. In addition, they provide an opportunity to project the expected incidence of microcephaly in multiple dengue endemic locations across Colombia and the American continent. Detailed knowledge of dengue transmission should be use to target efforts against Zika and other flaviviruses.",BiorXiv,March 31, 2016,Yes,,No,"Zika, indirect evidence or other topic",Scientific (journal) article,No,Original research,No,Yes,610,Clinical/epidemiological research,Ecological study/outbreak report
611,"Reefhuis, Emerg Infect Dis, 2016",Reefhuis,"Reefhuis, J; Gilboa, Suzanne M, Johansson, Michael A, Valencia, Diana, Simeone, Regina M, Hills, Susan L, Polen, Kara, Jamieson, Denise J, Petersen, Lyle R, Honein, Margaret A",Projecting Month of Birth for At-Risk Infants after Zika Virus Disease Outbreaks,Emerg Infect Dis,22,5,828-832,2016,2010-present,,,10.3201/eid2205.160290,1906,English,http://wwwnc.cdc.gov/eid/article/22/5/16-0290_article,"Centers for Disease Control and Prevention, 1600 Clifton Rd NE, Mailstop E86, Atlanta, GA 30329-4027, USA; nzr5@cdc.gov",United States,Americas,United States,Not reported/unknown,,"The marked increase in infants born with microcephaly in Brazil after a 2015 outbreak of Zika virus disease suggests an association between maternal Zika virus infection and congenital microcephaly. To project the timing of delivery of infants born to mothers infected during early pregnancy in 1 city in Bahia State, Brazil, we incorporated data on re- ported Zika cases and microcephaly cases into a graphical schematic of weekly birth cohorts. We projected that these births would occur through February 2016. Applying simi- lar projections to a hypothetical location at which Zika virus transmission started in November, we projected that full- term infants at risk for Zika virus infection would be born dur- ing April-September 2016. We also developed a modifiable spreadsheet tool that public health officials and researchers can use for their countries to plan for deliveries of infants to women who were infected with Zika virus during different pregnancy trimesters.",EID,March 31, 2016,Yes,,Yes,,Scientific (journal) article,Yes,Original research,Yes,No,912,Clinical/epidemiological research,Ecological study/outbreak report
612,"Secretaria de Saúde do Estado de Pernambuco. Secretaria executiva de Vigilância em Saúde. Brasil, , 2016",Secretaria de Saúde do Estado de Pernambuco. Secretaria executiva de Vigilância em Saúde. Brasil,Secretaria de Saúde do Estado de Pernambuco. Secretaria executiva de Vigilância em Saúde. Brasil,Protocolo Clínico e Epidemiológico para investigação de casos de microcefalia no estado de Pernambuco / Clinical and Epidemiological protocol for investigating cases of microcephaly in the state of Pernambuco.,,,,,2016,2010-present,,,,1812,,,,,,,,"Clinical Protocols/standards, Disease Outbreaks/prevention & control, Microcephaly/embryology, Epidemiological Surveillance, Exanthema/diagnosis, Specimen Handling/methods, Disease Notification/standards,  Microcephaly/diagnosis, Pregnancy Complications/epidemiology, Serologic Tests/methods, Brazil, Parvovirus B19, Human, Dengue/virology, Chikungunya virus, Mosquito Control/methods,",,LILACS,March 31, 2016,No,No full-text obtained yet,,,Surveillance report or data,,,No,Yes,612,Clinical/epidemiological research,Ecological study/outbreak report
613,"Ministério da Saúde. Secretaria de Vigilância em Saúde. Departamento de Vigilância das Doenças Transmissíveis. Brasil, , 2016",Ministério da Saúde. Secretaria de Vigilância em Saúde. Departamento de Vigilância das Doenças Transmissíveis. Brasil,Ministério da Saúde. Secretaria de Vigilância em Saúde. Departamento de Vigilância das Doenças Transmissíveis. Brasil,Protocolo de vigilância e resposta à ocorrência de microcefalia relacionada à infecção pelo vírus Zika / Surveillance protocol and response to the occurrence of microcephaly related to infection by viruses zika.,,,,,2016,2010-present,,,,1811,,,,,,,,,"Este protocolo tem como objetivo prover a profissionais de saúde e áreas técnicas de vigilância em saúde informações gerais, orientações técnicas e diretrizes relacionadas às ações de vigilância das microcefalias em todo território nacional. Deve ser ressaltado que as informações e recomendações aqui presentes e agora divulgadas foram fundamentadas e estabelecidas a partir das discussões conduzidas entre áreas técnicas do Ministério da Saúde do Brasil e especialistas de diversas áreas da medicina, epidemiologia, estatística, geografia e laboratório, além de representantes das Secretarias de Saúde de Estados e Municípios afetados. O Sistema Único de Saúde (SUS) concluiu a primeira etapa para elucidação desse evento, com investigações realizadas desde outubro, quando o Ministério da Saúde recebeu as primeiras notificações da Secretaria de Saúde do Estado de Pernambuco, até 28 de novembro de 2015, quando o Ministério da Saúde reconheceu a relação entre a presença do vírus e a ocorrência de microcefalias e óbitos. Esse reconhecimento é inédito na literatura nacional e internacional e só foi possível pelo empenho de médicos, pesquisadores e instituições de todo o Brasil que se uniram em prol de um objetivo comum que é a elucidação da causa da ocorrência dessas microcefalias. Até o momento, foram consolidadas algumas importantes evidências que sustentam a decisão do Ministério da Saúde no reconhecimento desta relação, como: Constatação de que os padrões de distribuição dos casos suspeitos de microcefalia pós-infecciosa apresentam características de dispersão e não indicam concentração espacial; Constatação de que os primeiros meses de gestação...(AU)",LILACS,March 31, 2016,No,No full-text obtained yet,,,Surveillance report or data,,,No,Yes,613,Clinical/epidemiological research,Ecological study/outbreak report
614,"Ministério da Saúde. Secretaria de Vigilância em Saúde. Departamento de Vigilância das Doenças Transmissíveis. Brasil, , 2016",Ministério da Saúde. Secretaria de Vigilância em Saúde. Departamento de Vigilância das Doenças Transmissíveis. Brasil,Ministério da Saúde. Secretaria de Vigilância em Saúde. Departamento de Vigilância das Doenças Transmissíveis. Brasil,Protocolo de vigilância e resposta à ocorrência de microcefalia relacionada à infecção pelo vírus zika / Protocol for surveillance and response to the occurrence of microcephaly related to zika virus infection / Protocolo de vigilancia y respuesta a la ocurrencia de casos de microcefalia relacionada con la infección por el virus zika.,,,,,2016,2010-present,,,,1815,,,,,,,,"Microcephaly, Viruses, Flavivirus Infections , Brazil/epidemiology, Humans, Male, Female","Este protocolo tem como objetivo prover a profissionais de saúde e áreas técnicas de vigilância em saúde informações gerais,orientações técnicas e diretrizes relacionadas às ações de vigilância das microcefalias em todo território nacional. Deve ser ressaltado que as informações e recomendações aqui presentes e agora divulgadas foram fundamentadas e estabelecidas a partir das discussões conduzidas entre áreas técnicas do Ministério da Saúde do Brasil e especialistas de diversas áreas da medicina, epidemiologia, estatística, geografia e laboratório,além de representantes das Secretarias de Saúde de Estados e Municípios afetados. O Sistema Único de Saúde (SUS) concluiu a primeira etapa para elucidação desse evento, com investigações realizadas desde outubro,quando o Ministério da Saúde recebeu as primeiras notificações da Secretaria de Saúde do Estado de Pernambuco,até 28 de novembro de 2015, quando o Ministério da Saúde reconheceu a relação entre a presença do vírus e a ocorrência de microcefalias e óbitos...(AU)",LILACS,March 31, 2016,No,No full-text obtained yet,,,Surveillance report or data,,,No,Yes,614,Clinical/epidemiological research,Ecological study/outbreak report
615,"ECDC, Rapid risk assessment, 21 January 2016, 2016",ECDC,ECDC,Rapid risk assessment. Zika virus disease epidemic: potential association with microcephaly and Guillain-Barré syndrome. First update 21 January 2016,"Rapid risk assessment, 21 January 2016","Rapid risk assessment, 21 January 2016",,,2016,2010-present,,,,1873,,http://ecdc.europa.eu/en/publications/Publications/rapid-risk-assessment-zika-virus-first-update-jan-2016.pdf,,Sweden,Europe,,Public/Government,,,ECDC,March 31, 2016,Yes,,Yes,,Surveillance report or data,,,No,Yes,615,Clinical/epidemiological research,Case report
616,"ECDC, , 2016",ECDC,ECDC,Rapid risk assessment. Zika virus disease epidemic: potential association with microcephaly and Guillain-Barré syndrome. Fourth update 9 March 2016,,,,,2016,2010-present,,,,1868,,,,Sweden,Europe,,Public/Government,,,ECDC,March 31, 2016,Yes,,No,"Zika, indirect evidence or other topic",Surveillance report or data,,,No,Yes,616,Clinical/epidemiological research,Ecological study/outbreak report
617,"ECDC, , 2016",ECDC,ECDC,Rapid risk assessment. Zika virus disease epidemic: potential association with microcephaly and Guillain-Barré syndrome. Second update 8 February 2016,,,,,2016,2010-present,,,,1867,,,,Sweden,Europe,,Public/Government,,,ECDC,March 31, 2016,Yes,,No,"Zika, indirect evidence or other topic",Surveillance report or data,,,No,Yes,617,Clinical/epidemiological research,Ecological study/outbreak report
618,"ECDC, , 2016",ECDC,ECDC,Rapid risk assessment. Zika virus disease epidemic: potential association with microcephaly and Guillain-Barré syndrome. Third update 23 February 2016,,,,,2016,2010-present,,,,1872,,,,Sweden,Europe,,Public/Government,,,ECDC,March 31, 2016,Yes,,No,"Zika, indirect evidence or other topic",Surveillance report or data,,,No,Yes,618,Clinical/epidemiological research,Ecological study/outbreak report
619,"Yacoub, F1000Res, 2016",Yacoub,"Yacoub, S.; Mongkolsapaya, J.; Screaton, G.",Recent advances in understanding dengue,F1000Res,5,,,2016,2010-present,,26918159,10.12688/f1000research.6233.1,1838,,http://www.ncbi.nlm.nih.gov/pubmed/26918159,"Department of medicine, Imperial College London, London, UK; Oxford University Clinical research Unit, Wellcome Trust Major Overseas Programme, Ho Chi Minh City, Vietnam.; Department of medicine, Imperial College London, London, UK; Dengue Hemorrhagic Fever Research Unit, Office for Research and Development, Siriraj Hospital, Mahidol University, Bangkok, Thailand.; Department of medicine, Imperial College London, London, UK.",,,,,Flavivirus; dengue; dengue virus,"Dengue is an emerging threat to billions of people worldwide. In the last 20 years, the incidence has increased four-fold and this trend appears to be continuing. Caused by one of four viral serotypes, dengue can present as a wide range of clinical phenotypes with the severe end of the spectrum being defined by a syndrome of capillary leak, coagulopathy, and organ impairment. The pathogenesis of severe disease is thought to be in part immune mediated, but the exact mechanisms remain to be defined. The current treatment of dengue relies on supportive measures with no licensed therapeutics available to date. There have been recent advances in our understanding of a number of areas of dengue research, of which the following will be discussed in this review: the drivers behind the global dengue pandemic, viral structure and epitope binding, risk factors for severe disease and its pathogenesis, as well as the findings of recent clinical trials including therapeutics and vaccines. We conclude with current and future dengue control measures and key areas for future research.",F1000,March 31, 2016,No,Unrelated to Zika virus,,,Scientific (journal) article,Yes,Review,No,Yes,619,Clinical/epidemiological research,Epidemiological/clinical review
620,"Moreno, arXiv, 2016",Moreno,"Moreno, Victor, Espinoza, Baltazar, Holechek, Susan A., Castillo-Chavez, Carlos",Role of short-term dispersal on the dynamics of Zika virus,arXiv,,,,2016,2010-present,,,,1909,,,,,,,,,"In November 2015, El Salvador reported their first case of Zika virus (Zv) leading to an explosive outbreak that in just two months had over 6000 suspected cases. Many communities along with national agencies initiated the process to implement control measures that ranged from vector control and the use of repellents to the suggestion of avoiding pregnancies for two years, the latter one, in response to the growing number of microcephaly cases in Brazil. In our study, we explore the impact of short term mobility between two interconnected communities where disparities and violence contribute to the Zv epidemic. Using the Lagrangian approach along with a two-patch model, our results, via simulation, shows that short term mobility could be beneficial in the control of a Zv outbreak when used in combination with other control measures, but it could be detrimental when the reproductive number is too high. This paper is dedicated to the inauguration of the Centro de Modelamiento Matem\'{a}tico Carlos Castillo-Ch\'{a}vez at Universidad Francisco Gavidia in San Salvador, El Salvador.",ArXiv,March 31, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,No,Original research,No,Yes,620,Clinical/epidemiological research,Modelling study
621,"Check Hayden, Nature, 2016",Check Hayden,"Check Hayden, E.",Scientists probe Zika link to birth defects: Mosquito-borne virus is now present in 33 countries,Nature,530,7589,142-143,2016,2010-present,,20160132158,http://dx.doi.org/10.1038/530142a,1552,English,"http://www.nature.com/nature/index.html, http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emed13&AN=20160132158",E. Check Hayden,,,,,"congenital malformation/cn [Congenital Disorder], Flaviviridae, Flavivirus infection, human, knowledge, mosquito, nonhuman, note, priority journal, scientist, Zika infection, zika virus",,Embase,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,News item or lay press,,,No,Yes,621,,
622,"Martinez-Bakker, PeerJ Preprints, 2016",Martinez-Bakker,"Martinez-Bakker, ME Micaela E",Seasonally-timing pregnancy: an ecological perspective on the prevention of mother-to-child transmission of Zika virus,PeerJ Preprints,,,,2016,2010-present,,,10.7287/peerj.preprints.1818v1,1953,English,,,,,,,"Zika, childhood, family planning, infectious disease, microcephaly, mosquito, pregnancy, season","Zika virus is an emerging pathogen vectored by the Aedes aegypti mosquito. Zika virus can be transmitted from mother-to-child in utero and mounting evidence suggests it is responsible for the cluster of microcephaly in newborns in Brazil. There is a great deal of uncertainty regarding the pathology of Zika virus during pregnancy. Based on 2015 birth rates, in 2016 there are expected to be > 8,600,000 births in countries with ongoing Zika virus transmission. In the face of this threat, the WHO is strategically targeting prevention of infection in pregnant women and funding contraception use in epidemic regions. In countries like Brazil, with millions of births per year, I propose that mother-to-child transmission of Zika virus can be curtailed by seasonally-timing pregnancy to minimize maternal exposure to Zika. Ae. aegypti has seasonal changes in its abundance and Flavivirus transmission competence. By seasonally planning pregnancy, this aspect of vector ecology can be leveraged to align sensitive periods of gestation with the low-transmission season.",PeerJ Preprints,March 31, 2016,Yes,,No,"Zika, not relevant to causality framework",Scientific (journal) article,No,Original research,No,Yes,622,Clinical/epidemiological research,Modelling study
623,"Charrel, Bull World Health Organ, 2016",Charrel,"Charrel, Rémi N.; Leparc-Goffart, Isabelle; Pas, Suzan; de Lamballerie, Xavier; Koopmans, Marion; Reusken, Chantal",State of knowledge on Zika virus for an adequate laboratory response,Bull World Health Organ,,,,2016,2010-present,,,10.2471/blt.16.171207,1826,,,,,,,,,"Objective  : The current epidemic with Zika virus (ZIKV) has r  esulted in a large increase in   diagnostic requests for ZIKV in the America's but a  lso elsewhere in travelers returning from the   affected areas, especially for pregnant women with   or without (past) clinical symptoms of a   ZIKV infection. To support the laboratory preparedn  ess and response for ZIKV we assessed the   current state of knowledge on ZIKV diagnostics and   identified present knowledge gaps for   adequate ZIKV diagnostics that need to be addressed   urgently.    Methods  : We reviewed essential ZIKV background information   and current information on   ZIKV diagnostics and human ZIKV diagnosis through a   literature search, using 'Zika', ZIKV as   search terms in PubMed. In addition we obtained inf  ormation through personal communication   within European preparedness networks and informati  on provided with commercially available   diagnostic tests.   Findings  : Essential knowledge on geographic spread, pathoge  n characteristics, life-cycle,   infection kinetics, available tests for molecular-b  ased and serology-based diagnosis and biosafety   issues are reviewed. Specifics of tests used for hu  man ZIKV diagnosis are discussed in the   context of the current outbreak strain.    Conclusion  : Besides provision of essential ZIKV knowledge to   the world laboratory community,   knowledge gaps have been identified that need to be   addressed urgently.    •   Rapid and extensive field validation of available   molecular and serology tests in   background of both affected areas and areas unaffec  ted but welcoming returning travellers.   Special focus should be given to the patient popula  tion of pregnant women.   •   Monitoring of  genomic diversity of circulating Z  IKV strains to allow verification against   operational molecular tests to ensure continuous se  nsitivity.   •   Development of External Quality Assessments (EQA)   for both molecular and serology   testing for multiple sample types.     •   Insight in infection kinetics should be obtained   through prospective studies, including   pregnant women as well, to determine ideal sampling   type or combinations thereof and sampling   time. This should focus on plasma/serum, urine and   saliva combinations.   •   The availability of reagents for diagnostic devel  opment should be facilitated.   ",WHO Zika open,March 31, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,No,Review,No,Yes,623,Clinical/epidemiological research,Epidemiological/clinical review
624,"Cornel, F1000Res, 2016",Cornel,"Cornel, Anthony J., Holeman, Jodi, Nieman, Catelyn C., Lee, Yoosook, Smith, Charles, Amorino, Mark, Brisco, Katherine, Barrera, Roberto, Lanzaro, Gregory C., Mulligan Iii, F. Stephen","Surveillance, insecticide resistance and control of an invasive Aedes aegypti (Diptera: Culicidae) population in California",F1000Res,5,,194,2016,2010-present,,,10.12688/f1000research.8107.2,1833,,,,,,,,,"The invasion and subsequent establishment in California of Aedes aegypti in 2013 has created new challenges for local mosquito abatement and vector control districts. Studies were undertaken to identify effective and economical strategies to monitor the abundance and spread of this mosquito species as well as for its control. Overall, BG Sentinel (BGS) traps were found to be the most sensitive trap type to measure abundance and spread into new locations. Autocidal-Gravid-Ovitraps (AGO-B), when placed at a site for a week, performed equally to BGS in detecting the presence of female Ae. aegypti. Considering operational cost and our findings, we recommend use of BGS traps for surveillance in response to service requests especially in locations outside the known infestation area. We recommend AGO-Bs be placed at fixed sites, cleared and processed once a week to monitor mosquito abundance within a known infestation area. Long-term high density placements of AGO-Bs were found to show promise as an environmentally friendly trap-kill control strategy. California Ae. aegypti were found to be homozygous for the V1016I mutation in the voltage gated sodium channel gene, which is implicated to be involved in insecticide resistance. This strain originating from Clovis, California was resistant to some pyrethroids but not to deltamethrin in bottle bio-assays. Sentinel cage ultra-low-volume (ULV) trials using a new formulation of deltamethrin (DeltaGard®) demonstrated that it provided some control (average of 56% death in sentinel cages in a 91.4 m spray swath) after a single truck mounted aerial ULV application in residential areas.",F1000,March 31, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Original research,No,Yes,624,Environmental and vector research,Other ecological
625,"Nau, Revue Medicale Suisse, 2016",Nau,"Nau, J. Y.","The American epidemic of Zika, or medicine facing religion",Revue Medicale Suisse,12,504,282-283,2016,2010-present,,20160117668,,1556,English,"http://www.revmed.ch/rms/content/download/233478/3650338/version/2/file/RMS_504_243.pdf, http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emed13&AN=20160117668",J.-Y. Nau,,,,,"religion, short survey, virus infection, Zika virus infection",,Embase,March 31, 2016,No,Duplicate of existing record,,,,,,,,,,
626,"Zmurko, PLoS Negl Trop Dis, 2016",Zmurko,"Zmurko, Joanna; Marques, Rafael E.; Schols, Dominique; Verbeken, Erik; Kaptein, Suzanne J. F.; Neyts, Johan",The viral polymerase inhibitor 7-deaza-2'-C-methyladenosine is a potent inhibitor of in 1 vitro Zika virus replication and delays disease progression in a robust mouse infection model,PLoS Negl Trop Dis,10,5,,2016,2010-present,,,10.1101/041905,1940,,http://biorxiv.org/content/biorxiv/early/2016/03/01/041905.full.pdf,,Belgium,Europe,Belgium,Mixed,,"Zika virus (ZIKV) is an emerging flavivirus typically causing a dengue-like febrile illness, but neurological complications, such as microcephaly in newborns, have potentially been linked to this viral infection. We established a panel of in vitro assays to allow the identification of ZIKV inhibitors and demonstrate that the virβ and IFN-γ receptor knock-21 al polymerase inhibitor 7-deaza-2'-C-methyladenosine (7DMA) efficiently inhibits replication. Infection of AG129 (IFN-α/out) mice with ZIKV resulted in acute neutrophilic encephalitis with viral antigens accumulating in neurons of the brain and spinal cord. Additionally, high levels of viral RNA were detected in the spleen, liver and kidney, and levels of IFN-γ and IL-18 were systematically increased in serum of ZIKV-infected mice. Interestingly, the virus was also detected in testicles of infected mice. In line with its in vitro anti-ZIKV activity, 7DMA reduced viremia and delayed virus-induced morbidity and mortality in infected mice, which also validates this small animal model to assess the in vivo efficacy of novel ZIKV inhibitors. Since AG129 mice can generate an antibody response, and have been used in dengue vaccine studies, the model can also be used to assess the efficacy of ZIKV vaccines.",BiorXiv,March 31, 2016,Yes,,Yes,,Scientific (journal) article,No,Original research,No,Yes,626,Basic and applied biomedical research,Animal experiment
627,"Lucey, BMJ, 2016",Lucey,"Lucey, D. R.",Time for global action on Zika virus epidemic: Our response to infectious disease epidemics must be faster and smarter,BMJ,352 (no pagination),i781,,2016,2010-present,,20160199030,http://dx.doi.org/10.1136/bmj.i781,1521,English,http://www.bmj.com/content/352/bmj.i781.full.pdf+html,"(Lucey) Department of Medicine, Infectious Diseases, Georgetown University Medical Center, Washington, DC, United States, D.R. Lucey, Department of Medicine, Infectious Diseases, Georgetown University Medical Center, Washington, DC, United States. E-mail: DRL23@Georgetown.edu",,,,,"clinical feature, disease association, editorial, epidemic, human, infection control, infection prevention, infection risk, microcephaly, priority journal, public health, sexual transmission, virus infection, virus mutation, virus transmission, Zika virus infection",,Embase,March 31, 2016,No,Duplicate of existing record,,,,,,,,,,
628,"Lessler, bioRxiv, 2016",Lessler,"Lessler, Justin, Ott, Cassandra T., Carcelen, Andrea C., Konikoff, Jacob M., Williamson, Joe, Bi, Qifang, Reich, Nicholas G., Cummings, Derek A. T., Kucirka, Lauren M., Chaisson, Lelia H.",Times to Key Events in the Course of Zika Infection and their Implications for Surveillance: A Systematic Review and Pooled Analysis,bioRxiv,,,,2016,2010-present,,,10.1101/041913,1939,,http://biorxiv.org/content/biorxiv/early/2016/03/02/041913.full.pdf,,,,,,,"Background Evidence suggests that Zika virus has driven a 10-fold increase in babies born with microcephaly in Brazil, prompting the WHO to declare a Public Health Emergency of International Concern. However, little is known about the natural history of infection. These data are critical for implementation of surveillance and control measures such as protecting the blood supply. Methods We conducted a systematic review and pooled analysis to estimate the distribution of times from Zika infection to symptom onset, seroconversion, and viral clearance, and analyzed their implications for surveillance and blood supply safety. Results Based on 25 case reports, we estimate the median incubation period of Zika virus infection is 5.9 days (95% CI: 4.4-7.6), and that 95% of cases will develop symptoms by 11.1 days post-infection (95% CI: 7.6-18.0). On average seroconversion occurs 9.0 days (95% CI, 7.0-11.6) after infection, and virus is detectable in blood for 9.9 days (95% CI: 6.8-21.4). In 5% of cases detectable virus persists for over 18.9 days (95% CI: 12.6-79.5). The baseline (no screening) risk of a blood donation being infected with Zika increases by approximately 1 in 10,000 for every 1 per 100,000 person-days increase in Zika incidence. Symptom based screening reduces this by 7% (RR 0.93, 93% CI 0.86-0.99), and antibody screening by 29% (RR 0.71, 95% CI: 0.28-0.88). Conclusions Symptom or antibody-based surveillance can do little to reduce the risk of Zika contaminated blood donations. High incidence areas may consider PCR testing to identify lots safe for use in pregnant women.",BiorXiv,March 31, 2016,Yes,,No,"Zika, not relevant to causality framework",Scientific (journal) article,No,Review,No,Yes,628,Clinical/epidemiological research,Epidemiological/clinical review
629,"Kucharski, bioRxiv, 2016",Kucharski,"Kucharski, Adam J, Funk, Sebastian, Eggo, Rosalind M M, Mallet, Henri-Pierre, Edmunds, John, Nilles, Eric J",Transmission dynamics of Zika virus in island populations: a modelling analysis of the 2013-14 French Polynesia outbreak,bioRxiv,,,,2016,2010-present,,,10.1101/038588,1948,,http://biorxiv.org/content/biorxiv/early/2016/02/11/038588.full.pdf,,,,,,,"Between October 2013 and April 2014, more than 30,000 cases of Zika virus (ZIKV) disease were estimated to have attended healthcare facilities in French Polynesia. ZIKV has also been reported in Africa and Asia, and in 2015 the virus spread to South America and the Caribbean. Infection with ZIKV has been associated with neurological complications including Guillain-Barre Syndrome (GBS) and microcephaly, which led the World Health Organization declare a Public Health Emergency of International Concern in February 2015. To better understand the transmission dynamics of ZIKV, we used a mathematical model to examine the 2013-14 outbreak on the six major archipelagos of French Polynesia. Our median estimates for the basic reproduction number ranged from 1.9-3.1, with an estimated 10.9% (95% CI: 6.97-16.8%) of total infections reported. As a result, we estimated that 86% (95% CI: 75-93%) of the total population of the six archipelagos were infected during the outbreak. There were 42 GBS cases reported during the ZIKV outbreak in French Polynesia, but the presence of a large number of unreported ZIKV infections could have implications for the design of case-control studies to further investigate a possible association between the two. Based on the demography of French Polynesia, our results also imply that if ZIKV infection provides complete protection against future infection, it would take 15-20 years before there are a sufficient number of susceptible individuals for ZIKV to re-emerge, which is on the same timescale as the circulation of dengue virus serotypes in the region. Our analysis suggests that ZIKV may exhibit similar dynamics to dengue virus in island populations, with transmission characterised by large, sporadic outbreaks with a high proportion of asymptomatic or unreported cases.",BiorXiv,March 31, 2016,Yes,,No,"Zika, not relevant to causality framework",Scientific (journal) article,No,Original research,No,Yes,629,Clinical/epidemiological research,Modelling study
630,"Schuck-Paim, PLoS Curr, 2016",Schuck-Paim,"Schuck-Paim, Cynthia  López, Daniel  Simonsen, Lone  Alonso, Wladimir",Unintended Pregnancies in Brazil - A Challenge for the Recommendation to Delay Pregnancy Due to Zika,PLoS Curr,,,,2016,2010-present,,,10.1371/currents.outbreaks.7038a6813f734c1db547240c2a0ba291,1892,,,,,,,,,"Because of the potential link between the ongoing Zika virus outbreak and a surge in the number of cases of congenital microcephaly, officials in Latin America have recommended that women postpone pregnancy until this association is firmly established or the outbreak subsides. However, in all these countries a large proportion of babies are still born out of unplanned pregnancies. Teenage girls are particularly at high risk, as they often lack access to preventive contraception methods, or the knowledge to use them appropriately. To gauge the magnitude of the barriers preventing the implementation of such a recommendation in Brazil, the country so far most affected by the Zika epidemic, we evaluated pregnancy rates in teenage girls, and their spatial heterogeneity in the country, in recent years (2012-2014). Nearly 20% of children born in Brazil today (~560,000 live births) are by teenage mothers. Birth incidence is far higher in the tropical and poorer northern states. However, in absolute terms most births occur in the populous southeastern states, matching to a large extent the geographic distribution of dengue (an indicator of suitable climatic and sociodemographic conditions for the circulation of Aedes mosquitoes). These findings indicate that recommendation to delay pregnancy will leave over half a million pregnant adolescents in Brazil vulnerable to infection every year if not accompanied by effective education and real access to prevention.",PLoS,March 31, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Original research,No,Yes,630,Clinical/epidemiological research,Ecological study/outbreak report
631,"Craig, Bull World Health Organ, 2016",Craig,"Craig, Adam T., Butler, Michelle T., Pastmore, Roberta, Paterson, Beverley J., Durrheim, David N.","Update on Zika virus transmission in the Pacific islands, 2007 to February 2016 and failure of acute flaccid paralysis surveillance to signal Zika emergence in this setting",Bull World Health Organ,,,,2016,2010-present,February 19, 2016,,10.2471/blt.16.171892,1827,English,http://www.who.int/bulletin/online_first/16-171892.pdf,email: adam@adamcraig.com.au,Australia,Pacific,Australia,Not reported/unknown,,"Objective: To describe the distribution and magnitude of Zika virus (ZIKV) infections reported in the Pacific islands from 2007 to February 2016; and explore the utility of routine acute flaccid paralysis (AFP) surveillance to detect ZIKV emergence.  Method: We searched for evidence of ZIKV cases and outbreaks in the Pacific using a PubMed search, reviewed Pacific peer communication channels and through personal communication with relevant WHO staff. Routine acute flaccid paralysis reporting data from 2000 to 2015 was reviewed to determine whether unexpected surveillance exceedances correlated with ZIKV emergence in specific Pacific island countries. Findings: We report nine ZIKV outbreaks in eight Pacific islands countries and areas (Yap State, Federal States of Micronesia (2007), French Polynesia (2013-14), Cook Islands (2014), Easter Island (2014), New Caledonia (2014 and 2015), Solomon Islands (2015) Tonga (2016) and American Samoa (2016), and a further three Pacific countries that detected cases (but have not reported domestic transmission): Vanuatu (2015), Fiji (2015), and Samoa (2015). Despite the reported increase in Guillain-Barre syndrome (AFP) in Latin America, review of fluctuations in detection rates in Pacific Islands found no correlation with ZIKV emergence.  Conclusion: Although no spatial correlation between AFP surveillance data and reported Zika infections was found in the Pacific island context we recommend that the utility of such a surveillance strategy be further tested in countries that are vulnerable to ZIKV outbreak and have large populations under the age of 15 years.",WHO Zika open,March 31, 2016,Yes,,Yes,,Scientific (journal) article,No,Original research,No,Yes,631,Clinical/epidemiological research,Ecological study/outbreak report
632,"Ministério da Saúde. Brasil, , 2016",Ministério da Saúde. Brasil,Ministério da Saúde. Brasil,Virus Zika: informações ao publico / Zika virus: information to the public.,,,,,2016,2010-present,,,,1816,,,,,,,,,,LILACS,March 31, 2016,No,No full-text obtained yet,,,Surveillance report or data,,,No,Yes,632,Clinical/epidemiological research,Ecological study/outbreak report
633,"Winkelmann, F1000Res, 2016",Winkelmann,"Winkelmann, E. R.; Luo, H.; Wang, T.",West Nile Virus Infection in the Central Nervous System,F1000Res,5,,,2016,2010-present,,26918172,10.12688/f1000research.7404.1,1836,,http://www.ncbi.nlm.nih.gov/pubmed/26918172,"Department of Microbiology & Immunology, University of Texas Medical Branch, Galveston, Texas, 77555, USA.; Department of Microbiology & Immunology, University of Texas Medical Branch, Galveston, Texas, 77555, USA; Department of Pathology, University of Texas Medical Branch, Galveston, Texas, 77555, USA.",,,,,West Nile Virus; arboviral encephalitis; central nervous system infection; flavivirus; west nile virus infection in central nervous system,"West Nile virus (WNV), a neurotropic single-stranded flavivirus has been the leading cause of arboviral encephalitis worldwide. Up to 50% of WNV convalescent patients in the United States were reported to have long-term neurological sequelae. Neither antiviral drugs nor vaccines are available for humans. Animal models have been used to investigate WNV pathogenesis and host immune response in humans. In this review, we will discuss recent findings from studies in animal models of WNV infection, and provide new insights on WNV pathogenesis and WNV-induced host immunity in the central nervous system.",F1000,March 31, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Review,No,Yes,633,Basic and applied biomedical research,Basic research review
634,"Barr, bioRxiv, 2016",Barr,"Barr, Kelli, Anderson, Benjamin, Long, Maureen",Working with Zika and Usutu Viruses in Vitro,bioRxiv,,,,2016,2010-present,,,10.1101/040139,1945,,http://biorxiv.org/content/biorxiv/early/2016/02/18/040139.full.pdf,,,,,,,"Usutu and Zika viruses are emerging arboviruses of significant medical and veterinary importance. These viruses have not been studied as well as other medically important arboviruses such as West Nile, dengue, or chikungunya viruses. As such, information regarding the behavior of Zika and Usutu viruses in the laboratory is dated. Usutu virus re-emerged in Austria in 2001 and has since spread throughout the European and Asian continents causing significant mortality among birds. Zika virus has recently appeared in the Americas and has exhibited unique characteristics of pathogenesis, including birth defects, and transmission. Information about the characteristics of Usutu and Zika viruses are needed to better understand the transmission, dispersal, and adaptation of these viruses in new environments. Since their initial characterization in the middle of last century, technologies and reagents have been developed that could enhance our abilities to study these pathogens. Currently, standard laboratory methods for these viruses are limited to 2-3 cell lines and many assays take several days to generate meaningful data. The goal of this study was to characterize these viruses in cell culture to provide some basic parameters to further their study. Cell lines from 17 species were permissive to both Zika and Usutu viruses. These viruses were able to replicate to significant titers in most of the cell lines tested. Moreover, cytopathic effects were observed in 8 of the cell lines tested. The data show that, unlike other flaviviruses, neither Zika nor Usutu viruses require an acidic environment to fuse with a host cell. This may provide a tool to help characterize events or components in the flavivirus fusion process. These data indicate that a variety of cell lines can be used to study Zika and Usutu viruses and may provide an updated foundation for the study of host-pathogen interactions, model development, and the development of therapeutics.",BiorXiv,March 31, 2016,Yes,,No,"Zika, indirect evidence or other topic",Scientific (journal) article,No,Original research,No,Yes,634,Basic and applied biomedical research,In vitro experiment
635,"Mohamad Idris, Malaysian Journal of Medical Sciences, 2016",Mohamad Idris,"Mohamad Idris, F.",Zika - A pandemic in progress?,Malaysian Journal of Medical Sciences,23,2,70-72,2016,2010-present,,20160192075,,1504,English,"http://journal.usm.my/journal/10SCmjms232.pdf, http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emed13&AN=20160192075","(Mohamad Idris) Department of Medical Microbiology and Parasitology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan 16150, Malaysia, F. Mohamad Idris, Department of Medical Microbiology and Parasitology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan 16150, Malaysia. E-mail: fauziahmi@usm.my",,,,,"Aedes, Arboviruses, Countermeasures, Pandemic, Zika virus, Aedes aegypti, Aedes albopictus, Alphavirus infection/ep [Epidemiology], Alphavirus infection/pc [Prevention], Arbovirus, article, chikungunya, Chikungunya virus, dengue, Dengue virus, epidemic, Guillain Barre syndrome, human, infection control, infection risk, microcephaly, neurologic disease, risk factor, sexual transmission, vector control, virus transmission, Zika virus infection/ep [Epidemiology], Zika virus infection/pc [Prevention]",The emerging threat of Zika virus outbreak with associated neurological abnormalities needs to be assessed in perspective in terms of its ability to cause a pandemic. This article attempts to throw some light on the issue.,Embase,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,635,,
636,"Logan, bioRxiv, 2016",Logan,"Logan, Ian S",ZIKA - How Fast Does This Virus Mutate ?,bioRxiv,,,,2016,2010-present,,,10.1101/040303,1944,,http://biorxiv.org/content/biorxiv/early/2016/03/08/040303.full.pdf,,,,,,,"The World Health Organisation has declared the present epidemic of infection with the Zika virus to be a Public Health Emergency of International Concern. The virus appears to have spread from Thailand to French Polynesia in 2013, and has since infected over a million people in the countries of South and Central America. In most cases the infection is mild and transient, but the virus does appear to be strongly neurotropic and the presumptive cause of both birth defects in foetuses and Guillain-Barr&eacute syndrome in some adults. In this paper the techniques and utilities developed in the study of mitochondrial DNA are applied to the Zika virus. As a result it is possible to show in a simple manner how a phylogenetic tree may be constructed and how the mutation rate of the virus can be measured. The study shows the mutation rate to vary between 12 and 25 bases a year, in a viral genome of 10,272 bases. This rapid mutation rate will enable the geographic spread of the epidemic to be monitored easily and may also prove useful in assisting the identification of preventative measures that are working, and those which are not.",BiorXiv,March 31, 2016,No,Duplicate of existing record,,,,,,,,,,
637,"Von Christina, Pharmazeutische Zeitung, 2016",Von Christina,"Von Christina, H. J.",Zika epidemic: Countermeasures are starting,Pharmazeutische Zeitung,161,8,,2016,2010-present,,20160178855,,1505,English,"http://www.pharmazeutische-zeitung.de/index.php?id=62179, http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emed13&AN=20160178855",,,,,,"epidemic, human, nonhuman, short survey, virus, virus infection/ep [Epidemiology], zika virus",,Embase,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,637,,
638,"WHO, Zika situation report. Neurological syndrome and congenital anomalies - 5 February 2016, 2016",WHO,WHO,Zika situation report. Neurological syndrome and congenital anomalies - 5 February 2016,,Zika situation report. Neurological syndrome and congenital anomalies - 5 February 2016,,,2016,2010-present,,,,1844,,http://apps.who.int/iris/bitstream/10665/204348/1/zikasitrep_5Feb2016_eng.pdf?ua=1,,Switzerland,Europe,,Public/Government,,,WHO,March 31, 2016,Yes,,Yes,,Surveillance report or data,,,No,Yes,638,Clinical/epidemiological research,Ecological study/outbreak report
639,"WHO, , 2016",WHO,WHO,Zika situation report. Zika and potential complications - 12 February 2016,,,,,2016,2010-present,,,,1845,,http://www.who.int/emergencies/zika-virus/situation-report/who-zika-situation-report-12-02-2016.pdf?ua=1,,Switzerland,Europe,,Public/Government,,,WHO,March 31, 2016,Yes,,No,"Zika, indirect evidence or other topic",Surveillance report or data,,,No,Yes,639,Clinical/epidemiological research,Ecological study/outbreak report
640,"WHO, , 2016",WHO,WHO,"Zika situation report. Zika virus, Microcephaly and Guillain-Barré syndrome - 10 March 2016",,,,,2016,2010-present,,,,1849,,http://apps.who.int/iris/bitstream/10665/204609/1/zikasitrep_10Mar2016_eng.pdf,,Switzerland,Europe,,Public/Government,,,WHO,March 31, 2016,Yes,,No,"Zika, indirect evidence or other topic",Surveillance report or data,,,No,Yes,640,Clinical/epidemiological research,Ecological study/outbreak report
641,"WHO, , 2016",WHO,WHO,"Zika situation report. Zika virus, Microcephaly and Guillain-Barré syndrome - 17 March 2016",,,,,2016,2010-present,,,,1850,,http://apps.who.int/iris/bitstream/10665/204633/1/zikasitrep_17Mar2016_eng.pdf?ua=1,,Switzerland,Europe,,Public/Government,,,WHO,March 31, 2016,Yes,,No,"Zika, indirect evidence or other topic",Surveillance report or data,,,No,Yes,641,Clinical/epidemiological research,Ecological study/outbreak report
642,"WHO, , 2016",WHO,WHO,"Zika situation report. Zika virus, Microcephaly and Guillain-Barré syndrome - 19 February 2016",,,,,2016,2010-present,,,,1846,,http://apps.who.int/iris/bitstream/10665/204454/1/zikasitrep_19Feb2016_eng.pdf,,Switzerland,Europe,,Public/Government,,,WHO,March 31, 2016,Yes,,No,"Zika, indirect evidence or other topic",Surveillance report or data,,,No,Yes,642,Clinical/epidemiological research,Ecological study/outbreak report
643,"WHO, , 2016",WHO,WHO,"Zika situation report. Zika virus, Microcephaly and Guillain-Barré syndrome - 24 March 2016",,,,,2016,2010-present,,,,1851,,http://apps.who.int/iris/bitstream/10665/204690/1/zikasitrep_24Mar2016_eng.pdf?ua=1,,Switzerland,Europe,,Public/Government,,,WHO,March 31, 2016,Yes,,No,"Zika, indirect evidence or other topic",Surveillance report or data,,,No,Yes,643,Clinical/epidemiological research,Ecological study/outbreak report
644,"WHO, , 2016",WHO,WHO,"Zika situation report. Zika virus, Microcephaly and Guillain-Barré syndrome - 26 February 2016",,,,,2016,2010-present,,,,1847,,http://apps.who.int/iris/bitstream/10665/204491/1/zikasitrep_26Feb2016_eng.pdf,,Switzerland,Europe,,Public/Government,,,WHO,March 31, 2016,Yes,,No,"Zika, indirect evidence or other topic",Surveillance report or data,,,No,Yes,644,Clinical/epidemiological research,Ecological study/outbreak report
645,"WHO, , 2016",WHO,WHO,"Zika situation report. Zika virus, Microcephaly and Guillain-Barré syndrome - 4 March 2016",,,,,2016,2010-present,,,,1848,,http://apps.who.int/iris/bitstream/10665/204526/2/zikasitrep_4Mar2016_eng.pdf?ua=1,,Switzerland,Europe,,Public/Government,,,WHO,March 31, 2016,Yes,,No,"Zika, indirect evidence or other topic",Surveillance report or data,,,No,Yes,645,Clinical/epidemiological research,Ecological study/outbreak report
646,"Wilson, bioRxiv, 2016",Wilson,"Wilson, James; Malone, Robert; Gagen, Julie Smith; Pabayo, Roman",Zika Virus Disease: A Simple Model Approach to Rapid Impact Assessment,bioRxiv,,,,2016,2010-present,,,10.1101/044248,1933,,http://biorxiv.org/content/biorxiv/early/2016/03/19/044248.full.pdf,,,,,,,"There has been substantial media attention regarding Zika infection as a threat to pregnancy, prompted by WHOs declaration of a Public Health Event of International Concern (PHEIC). Here we present a simple risk assessment model for two states within the continental United States at-risk for autochthonous transmission of Zika virus, Texas and Florida. Our simple impact assessment model is partially validating at this early interval in the crisis.",BiorXiv,March 31, 2016,Yes,,No,"Zika, not relevant to causality framework",Scientific (journal) article,No,Original research,No,Yes,646,Clinical/epidemiological research,Other clinical/epidemiological
647,"Garcez, Science, 2016",Garcez,"Garcez, P; Loiola, Erick C, Costa, Rodrigo F Madeiro da, Higa, Luiza, Trindade, Pablo, Delvecchio, Rodrigo, Nascimento, Juliana M, Brindeiro, Rodrigo M, Tanuri, Almicar, Rehen, Stevens K, PP, Garcez, EC, Loiola, RF, Madeiro da Costa, L, Higa, P, Trindade, R, Delvecchio, JM, Nascimento, RM, Brindeiro, A, Tanuri, SK, Rehen",Zika virus impairs growth in human neurospheres and brain organoids,Science,352,6287,816-8,2016,2010-present,May 13, 2016,,10.1126/science.aaf6116,1951,English,http://www.ncbi.nlm.nih.gov/pubmed/27064148,,Brazil,Americas,Brazil,Mixed,"cell death, cerebral organoids, microcephaly, stem cells, zika virus","Since the emergence of Zika virus (ZIKV), reports of microcephaly have increased dramatically in Brazil; however, causality between the widespread epidemic and malformations in fetal brains has not been confirmed. Here, we examine the effects of ZIKV infection in human neural stem cells growing as neurospheres and cerebral organoids. Using immunocytochemistry and electron microscopy, we show that ZIKV targets human brain cells, reducing their viability and growth as neurospheres and cerebral organoids. These results suggest that ZIKV abrogates neurogenesis during human brain development.",PeerJ Preprints,March 31, 2016,Yes,,Yes,,Scientific (journal) article,No,Original research,No,Yes,647,Basic and applied biomedical research,In vitro experiment
648,"Hibbeler, Deutsches Arzteblatt International, 2016",Hibbeler,"Hibbeler, B.",Zika virus infections: Risk for pregnant women,Deutsches Arzteblatt International,113,4,A137,2016,2010-present,,20160098870,,1560,English,"http://www.aerzteblatt.de/archiv/173684/Schwerer-Reflux-DRG-Code-fuer-Stimulationstherapie, http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emed13&AN=20160098870",,,,,,"female, human, note, pregnant woman, risk factor, virus infection, Zika virus infection",,Embase,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,648,,
649,"Hibbeler, Deutsches Arzteblatt International, 2016",Hibbeler,"Hibbeler, B.",Zika virus infections: What should be considered diagnostically,Deutsches Arzteblatt International,113,6,A236,2016,2010-present,,20160153763,,1527,English,"http://www.aerzteblatt.de/pdf.asp?id=174874, http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emed13&AN=20160153763",,,,,,"note, virus infection/di [Diagnosis], Zika virus infection/di [Diagnosis]",,Embase,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,649,,
650,"Butt, bioRxiv, 2016",Butt,"Butt, Azeem Mehmood, Nasrullah, Izza, Qamar, Raheel, Tong, Yigang",Zika virus outbreak in the Americas: Is Aedes albopictus an overlooked culprit?,bioRxiv,,,,2016,2010-present,,,10.1101/044594,1928,,http://biorxiv.org/content/biorxiv/early/2016/03/30/044594.full.pdf,,,,,,,"Codon usage patterns of viruses reflect a series of evolutionary changes that enable viruses to shape their survival rates and fitness toward the external environment and, most importantly, their hosts. In the present study, we employed multiple codon usage analysis indices to determine genotype specific codon usage patterns of Zika virus (ZIKV) strains from the current outbreak and those reported previously. Several genotype specific and common codon usage traits were noted in ZIKV coding sequences, indicative of independent evolutionary origins from a common ancestor. The overall influence of natural selection was found to be more profound than that of mutation pressure and acting on specific set of viral genes belonging to ZIKV strains of Asian genotype from the recent outbreak. Furthermore, an interplay of codon adaptation and deoptimization have been observed in ZIKV genomes. The collective findings of codon analysis in association with the geographical data of Aedes populations in the Americas suggests that ZIKV have evolved a dynamic set of codon usage patterns in order to maintain a successful replication and transmission chain within multiple hosts and vectors.",BiorXiv,March 31, 2016,Yes,,No,"Zika, indirect evidence or other topic",Scientific (journal) article,No,Original research,No,Yes,650,Basic and applied biomedical research,Sequence analysis and phylogenetics
651,"Ribeiro, Revista da Sociedade Brasileira de Medicina Tropical, 2016",Ribeiro,"Ribeiro, Guilherme Sousa, Kitron, Uriel",Zika virus pandemic: a human and public health crisis,Revista da Sociedade Brasileira de Medicina Tropical,49,,01. Mrz,2016,2010-present,,,,1809,,http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822016000100001&nrm=iso,,,,,,,,LILACS,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,651,,
652,"Pujhari, PeerJ Preprints, 2016",Pujhari,"Pujhari, S, Rasgon, JL",Zika virus: A newly emergent vector-borne public health threat in the Americas,PeerJ Preprints,,,,2016,2010-present,,,https://doi.org/10.7287/peerj.preprints.1781v1,1952,,,,,,,,,"Zika virus is a newly emergent mosquito-borne flavivirus. Once almost ignored epidemiologically, recent major outbreaks and links to neurological birth defects have focused attention on this neglected pathogen. We review the discovery, biology and symptomatology of Zika virus, what is known and not known about the mosquitoes that transmit the virus, conspiracy theories currently hampering control efforts, and potential avenues of Zika control. It is likely that Zika virus is here to stay in the Americas, so a thorough understanding of the complete epidemiological transmission cycle and potential effects on the human population will be critical for managing this new disease in the coming years.",PeerJ Preprints,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,No,Review,No,Yes,652,Clinical/epidemiological research,Epidemiological/clinical review
653,"Bewick, bioRxiv, 2016",Bewick,"Bewick, Sharon, Fagan, William F, Calabrese, Justin M, Agusto, Folashade",Zika Virus: Endemic Versus Epidemic Dynamics and Implications for Disease Spread in the Americas,bioRxiv,,,,2016,2010-present,,,10.1101/041897,1941,,http://biorxiv.org/content/biorxiv/early/2016/03/07/041897.full.pdf,,,,,,,"Since being introduced into Brazil in 2014, Zika virus (ZIKV) has spread explosively across Central and South America. Although the symptoms of ZIKV are generally mild, recent evidence suggests a relationship between prenatal exposure to ZIKV and microcephaly. This has led to widespread panic, including travel alerts and warnings to avoid pregnancy. Because ZIKV is an emerging disease, response efforts are complicated by limited understanding of disease dynamics. To this end, we develop a novel state- and class-structured compartment model for ZIKV. Our model shows that the risk of prenatal ZIKV exposure should decrease dramatically following the initial wave of disease, reaching almost undetectable levels in endemic systems. Our model also suggests that, depending on ZIVK transmission levels in the Americas, efforts to reduce ZIKV prenatal exposures through mosquito management and avoidance may have minimal benefit, and may even result in increased risk of microcephaly in later years of an outbreak.",BiorXiv,March 31, 2016,Yes,,No,"Zika, not relevant to causality framework",Scientific (journal) article,No,Original research,No,Yes,653,Clinical/epidemiological research,Modelling study
654,"Hohmann-Jeddi, Pharmazeutische Zeitung, 2016",Hohmann-Jeddi,"Hohmann-Jeddi, C.",Zika virus: Many questions remain unanswered,Pharmazeutische Zeitung,161,5,,2016,2010-present,,20160114211,,1559,English,"http://www.pharmazeutische-zeitung.de/index.php?id=61885, http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emed13&AN=20160114211",C. Hohmann-Jeddi,,,,,"article, nonhuman, virus, zika virus","Von Christina Hohmann-Jeddi / Bis vor Kurzem galt das Zika-Virus als harmlos, da es nur leichte Erkrankungsbilder verursacht. Doch jetzt löste der Erreger, der sich rasch in Mittel- und Südamerika ausbreitet, einen weltweiten Gesundheitsnotstand aus. Das Virus wird mit schwerwiegenden Schädelfehlbildungen bei Feten in Verbindung gebracht. Belegt ist der Zusammenhang nicht.",Embase,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,654,,
655,"Godlee, BMJ, 2016",Godlee,"Godlee, F.","Zika, and rapid diagnostic tests for malaria",BMJ,352 (no pagination),i841,,2016,2010-present,,20160205175,http://dx.doi.org/10.1136/bmj.i841,1500,English,"http://www.bmj.com/content/bmj/352/bmj.i841.full.pdf, http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emed13&AN=20160205175","(Godlee) BMJ, United States, F. Godlee, BMJ, United States. E-mail: fgodlee@bmj.com",,,,,"editorial, fever, health belief, health care personnel, human, malaria/di [Diagnosis], microcephaly, Pacific islands, prevalence, priority journal, publication, rapid test, South and Central America, virus, zika virus",,Embase,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,655,,
656,"Nau, Revue Medicale Suisse, 2016",Nau,"Nau, J. Y.",Zika: A pathophysiological and epidemiological equation with many unknowns,Revue Medicale Suisse,12,505,322-323,2016,2010-present,,20160148492,,1528,English,"http://www.revmed.ch/rms/content/download/234057/3656023/version/3/file/RMS_505_291.pdf, http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emed13&AN=20160148492",J.-Y. Nau,,,,,"epidemiological data, nonhuman, note, pathophysiology, virus, zika virus","Nous avons vu, il y a peu,1 ce qu'il pouvait en être des nouvelles inquiétudes inhérentes à la propagation rapide du virus Zika sur le continent américain. L'OMS vient de décréter qu'il s'agissait là d'une << urgence sanitaire mondiale >>. C'est là une bonne occasion de compléter ce tableau d'actualité avec des interrogations problématiques quant à la physiopathologie de cette infection virale et à la réalité chiffrée des conséquences tenues depuis quelques semaines pour acquises.En 2015, un groupe franco-thaïlandais était pour la première fois parvenu à décrire comment ce virus infectait l'homme suite à une piqûre de moustique puis de quelle manière il se propageait dans l'organisme infecté. Publié dans Journal of Virology,2 ce travail avait été mené par des chercheurs de l'Institut de recherches pour le développement (IRD), de l'Inserm, de l'Institut Pasteur et leurs partenaires thaïlandais (Mahidol University, Bangkok ; Prince of Songkla University, Songkla).On savait que le virus...",Embase,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,656,,
657,"Kindhauser, Bull World Health Organ, 2016",Kindhauser,"Kindhauser, Mary Kay; Allen, Tomas; Frank, Veronika; Santhana, Ravi Shankar; Dye, Christopher",Zika: the origin and spread of a mosquito-borne virus,Bull World Health Organ,,,,2016,2010-present,,,10.2471/blt.16.171082,1825,,,,,,,,,,WHO Zika open,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,No,Review,No,Yes,657,Clinical/epidemiological research,Epidemiological/clinical review
658,"Board on Health Sciences, , 2016",Board on Health Sciences,"Board on Health Sciences, Policy, Institute of, Medicine, Division on, Earth, Life, Studies, National Academies of Sciences, Engineering, Medicine,",Potential Research Priorities to Inform Public Health and Medical Practice for Domestic Zika Virus: Workshop in Brief,,,,,2016,2010-present,,26985518,10.17226/23404,1123,English,http://www.ncbi.nlm.nih.gov/pubmed/26985518,,,,,,,"Given the recent rapid spread of Zika virus (ZIKV) throughout the Americas and the presence of its vector mosquito species within parts of the United States, RADM Nicole Lurie, Assistant Secretary for Preparedness and Response, U.S. Department of Health and Human Services, determined an urgent need for additional research to better characterize ZIKV, especially those issues related to the means of transmission and infection during pregnancy. The National Academies of Sciences, Engineering, and Medicine convened a 1-day public workshop on February 16, 2016, to discuss and explore key factors associated with ZIKV.",Pubmed,March 31, 2016,No,"Zika, no original information (e.g. editorial)",,,Other,,,No,Yes,658,,
659,"Zundorf, Deutsche Apotheker Zeitung, 2015",Zundorf,"Zundorf, I.; Dingermann, T.",Brazil in health emergency: Zika - Once again a new viral infection,Deutsche Apotheker Zeitung,155,49,,2015,2010-present,,,,2010,,http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emed13&AN=20160200798; http://lshtmsfx.hosted.exlibrisgroup.com/lshtm?sid=OVID:embase&id=pmid:&id=doi:&issn=0011-9857&isbn=&volume=155&issue=49&spage=no+pagination&pages=no+pagination&date=2015&title=Deutsche+Apotheker+Zeitung&atitle=Brasilien+im+gesundheitsnotstand%3A+Zika+-+wieder+einmal+eine+neue+virusinfektion&aulast=Zundorf&pid=%3Cauthor%3EZundorf+I.%3BDingermann+T.%3C%2Fauthor%3E%3CAN%3E20160200798%3C%2FAN%3E%3CDT%3EJournal%3A+Article%3C%2FDT%3E,,,,,,,,Embase,April 11, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,659,,
660,"Dupont-Rouzeyrol, Emerg Infect Dis, 2015",Dupont-Rouzeyrol,"Dupont-Rouzeyrol, M.; O'Connor, O.; Calvez, E.; Daures, M.; John, M.; Grangeon, J. P.; Gourinat, A. C.","Co-infection with Zika and dengue viruses in 2 patients, New Caledonia, 2014",Emerg Infect Dis,21,2,381-382,2015,2010-present,,,,2119,,http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emed13&AN=25625687; http://lshtmsfx.hosted.exlibrisgroup.com/lshtm?sid=OVID:embase&id=pmid:25625687&id=doi:10.3201%2Feid2102.141553&issn=1080-6059&isbn=&volume=21&issue=2&spage=381&pages=381-382&date=2015&title=Emerging+infectious+diseases&atitle=Co-infection+with+Zika+and+dengue+viruses+in+2+patients%2C+New+Caledonia%2C+2014&aulast=Dupont-Rouzeyrol&pid=%3Cauthor%3EDupont-Rouzeyrol+M.%3BO%27Connor+O.%3BCalvez+E.%3BDaures+M.%3BJohn+M.%3BGrangeon+J.-P.%3BGourinat+A.-C.%3C%2Fauthor%3E%3CAN%3E25625687%3C%2FAN%3E%3CDT%3EJournal%3A+Article%3C%2FDT%3E; http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4313662/pdf/14-1553.pdf,,,,,,,,Embase,April 11, 2016,No,Duplicate of existing record,,,,,,,,,,
661,"Buathong, Am J Trop Med Hyg, 2015",Buathong,"Buathong, R.; Hermann, L.; Thaisomboonsuk, B.; Rutvisuttinunt, W.; Klungthong, C.; Chinnawirotpisan, P.; Manasatienkij, W.; Nisalak, A.; Fernandez, S.; Yoon, I. K.; Akrasewi, P.; Plipat, T.","Detection of Zika Virus Infection in Thailand, 2012-2014",Am J Trop Med Hyg,93,2,380-383,2015,2010-present,,,,2143,,http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emed13&AN=26101272; http://lshtmsfx.hosted.exlibrisgroup.com/lshtm?sid=OVID:embase&id=pmid:26101272&id=doi:10.4269%2Fajtmh.15-0022&issn=1476-1645&isbn=&volume=93&issue=2&spage=380&pages=380-383&date=2015&title=The+American+journal+of+tropical+medicine+and+hygiene&atitle=Detection+of+Zika+Virus+Infection+in+Thailand%2C+2012-2014&aulast=Buathong&pid=%3Cauthor%3EBuathong+R.%3BHermann+L.%3BThaisomboonsuk+B.%3BRutvisuttinunt+W.%3BKlungthong+C.%3BChinnawirotpisan+P.%3BManasatienkij+W.%3BNisalak+A.%3BFernandez+S.%3BYoon+I.-K.%3BAkrasewi+P.%3BPlipat+T.%3C%2Fauthor%3E%3CAN%3E26101272%3C%2FAN%3E%3CDT%3EJournal%3A+Article%3C%2FDT%3E; http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4530765/pdf/tropmed-93-380.pdf,,,,,,,"Zika virus (ZIKV) is an emerging mosquito-borne pathogen with reported cases in Africa, Asia, and large outbreaks in the Pacific. No autochthonous ZIKV infections have been confirmed in Thailand. However, there have been several cases reported in travelers returning from Thailand. Here we report seven cases of acute ZIKV infection in Thai residents across the country confirmed by molecular or serological testing including sequence data. These endemic cases, combined with previous reports in travelers, provide evidence that ZIKV is widespread throughout Thailand.",Embase,April 11, 2016,Yes,,No,"Zika, not relevant to causality framework",Scientific (journal) article,Yes,Original research,No,Yes,661,Clinical/epidemiological research,Case series
662,"Gourinat, Emerg Infect Dis, 2015",Gourinat,"Gourinat, A. C.; O'Connor, O.; Calvez, E.; Goarant, C.; Dupont-Rouzeyrol, M.",Detection of Zika virus in urine,Emerg Infect Dis,21,1,84-86,2015,2010-present,,,,2114,,http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emed13&AN=25530324; http://lshtmsfx.hosted.exlibrisgroup.com/lshtm?sid=OVID:embase&id=pmid:25530324&id=doi:10.3201%2Feid2101.140894&issn=1080-6059&isbn=&volume=21&issue=1&spage=84&pages=84-86&date=2015&title=Emerging+infectious+diseases&atitle=Detection+of+Zika+virus+in+urine&aulast=Gourinat&pid=%3Cauthor%3EGourinat+A.-C.%3BO%27Connor+O.%3BCalvez+E.%3BGoarant+C.%3BDupont-Rouzeyrol+M.%3C%2Fauthor%3E%3CAN%3E25530324%3C%2FAN%3E%3CDT%3EJournal%3A+Article%3C%2FDT%3E; http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4285245/pdf/14-0894.pdf,,,,,,,"We describe the kinetics of Zika virus (ZIKV) detection in serum and urine samples of 6 patients. Urine samples were positive for ZIKV >10 days after onset of disease, which was a notably longer period than for serum samples. This finding supports the conclusion that urine samples are useful for diagnosis of ZIKV infections. ",Embase,April 11, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Original research,No,Yes,662,Clinical/epidemiological research,Case series
663,"InVS, Point Epidemiologique CIRE Antilles Guyane, 2016",InVS,InVS,Point épidémio: Emergence du virus zika aux Antilles Guyane : Situation épidémiologique - 07 janvier 2016,Point Epidemiologique CIRE Antilles Guyane,1,,,2016,2010-present,January 7, 2016,,,2032,French,http://www.invs.sante.fr/fr/Publications-et-outils/Points-epidemiologiques/Tous-les-numeros/Antilles-Guyane/2016/Situation-epidemiologique-du-virus-Zika-aux-Antilles-Guyane.-Point-au-7-janvier-2016,,France,Europe,,Public/Government,,,Institute de veille sanitaire,April 11, 2016,Yes,,No,"Zika, indirect evidence or other topic",Surveillance report or data,,,No,Yes,663,Clinical/epidemiological research,Ecological study/outbreak report
664,"InVS, Point Epidemiologique CIRE Antilles Guyane, 2016",InVS,InVS,Point épidémio: Emergence du virus zika aux Antilles Guyane : Situation épidémiologique - 15 janvier 2016,Point Epidemiologique CIRE Antilles Guyane,2,,,2016,2010-present,January 15, 2016,,,2031,French,,,France,Europe,,Public/Government,,,Institute de veille sanitaire,April 11, 2016,Yes,,No,"Zika, indirect evidence or other topic",Surveillance report or data,,,No,Yes,664,Clinical/epidemiological research,Ecological study/outbreak report
665,"Ventura CV, Lancet, 2016",Ventura CV,"Ventura CV; Maia, M.; Bravo-Filho, V.; Gois, A. L.; Belfort, R., Jr.",Zika virus in Brazil and macular atrophy in a child with microcephaly,Lancet,387,10015,228,2016,2010-present,January 18, 2016,26775125,10.1016/s0140-6736(16)00006-4,2086,English,http://ac.els-cdn.com/S0140673616000064/1-s2.0-S0140673616000064-main.pdf?_tid=9c945494-ffbd-11e5-84d5-00000aacb35e&acdnat=1460362734_c0be4fe817b6e4143fd3aec7b264fef7; http://ac.els-cdn.com/S0140673616000064/1-s2.0-S0140673616000064-main.pdf?_tid=9cb0a55a-fffd-11e5-b548-00000aab0f01&acdnat=1460390222_df64365bb9a7fd8760801ff9957f4d54,"Department of Ophthalmology, Federal University of Sao Paulo, Sao Paulo, Brazil.; Department of Ophthalmology, Federal University of Sao Paulo, Sao Paulo, Brazil. Electronic address: clinbelf@uol.com.br.",,,,,Atrophy; Brazil/epidemiology; Female; Humans; Infant; Macula Lutea/ pathology; Male; Microcephaly/diagnosis/ etiology/virology; Retinal Diseases/diagnosis/ etiology/virology; Zika Virus; Zika Virus Infection/ complications/diagnosis,,Pubmed,April 11, 2016,No,Duplicate of existing record,,,,,,,,,,
666,"InVS, Point Epidemiologique CIRE Antilles Guyane, 2016",InVS,InVS,Point épidémio: Emergence du virus zika aux Antilles Guyane : Situation épidémiologique - 21 janvier 2016,Point Epidemiologique CIRE Antilles Guyane,3,,,2016,2010-present,January 21, 2016,,,2030,French,,,France,Europe,,Public/Government,,,Institute de veille sanitaire,April 11, 2016,Yes,,No,"Zika, indirect evidence or other topic",Surveillance report or data,,,No,Yes,666,Clinical/epidemiological research,Ecological study/outbreak report
667,"InVS, Point Epidemiologique CIRE Antilles Guyane, 2016",InVS,InVS,Point épidémio: Emergence du virus zika aux Antilles Guyane : Situation épidémiologique - 29 janvier 2016,Point Epidemiologique CIRE Antilles Guyane,4,,,2016,2010-present,January 29, 2016,,,2029,French,http://www.invs.sante.fr/fr/Publications-et-outils/Points-epidemiologiques/Tous-les-numeros/Antilles-Guyane/2016/Situation-epidemiologique-du-virus-Zika-aux-Antilles-Guyane.-Point-au-29-janvier-2016,,France,Europe,,Public/Government,,,Institute de veille sanitaire,April 11, 2016,Yes,,No,"Zika, indirect evidence or other topic",Surveillance report or data,,,No,Yes,667,Clinical/epidemiological research,Ecological study/outbreak report
668,"InVS, Point Epidemiologique CIRE Antilles Guyane, 2016",InVS,InVS,Point épidémio: Emergence du virus zika aux Antilles Guyane : Situation épidémiologique - 18 février 2016,Point Epidemiologique CIRE Antilles Guyane,6,,,2016,2010-present,February 18, 2016,,,2028,French,http://www.invs.sante.fr/fr/Publications-et-outils/Points-epidemiologiques/Tous-les-numeros/Antilles-Guyane/2016/Situation-epidemiologique-du-virus-Zika-aux-Antilles-Guyane.-Point-au-18-fevrier-2016,,France,Europe,,Public/Government,,,Institute de veille sanitaire,April 11, 2016,Yes,,No,"Zika, indirect evidence or other topic",Surveillance report or data,,,No,Yes,668,Clinical/epidemiological research,Ecological study/outbreak report
669,"InVS, Point Epidemiologique CIRE Antilles Guyane, 2016",InVS,InVS,Point épidémio: Emergence du virus zika aux Antilles Guyane : Situation épidémiologique - 25 février 2016,Point Epidemiologique CIRE Antilles Guyane,7,,,2016,2010-present,February 25, 2016,,,2027,French,http://www.invs.sante.fr/fr/Publications-et-outils/Points-epidemiologiques/Tous-les-numeros/Antilles-Guyane/2016/Situation-epidemiologique-du-virus-Zika-aux-Antilles-Guyane.-Point-au-25-fevrier-2016,,France,Europe,,Public/Government,,,Institute de veille sanitaire,April 11, 2016,Yes,,No,"Zika, indirect evidence or other topic",Surveillance report or data,,,No,Yes,669,Clinical/epidemiological research,Ecological study/outbreak report
670,"InVS, Point Epidemiologique CIRE Antilles Guyane, 2016",InVS,InVS,Point épidémio: Emergence du virus zika aux Antilles Guyane : Situation épidémiologique - 03 mars 2016,Point Epidemiologique CIRE Antilles Guyane,8,,,2016,2010-present,March 3, 2016,,,2026,French,http://www.invs.sante.fr/fr/Publications-et-outils/Points-epidemiologiques/Tous-les-numeros/Antilles-Guyane/2016/Situation-epidemiologique-du-virus-Zika-aux-Antilles-Guyane.-Point-au-3-mars-2016,,France,Europe,,Public/Government,,,Institute de veille sanitaire,April 11, 2016,Yes,,No,"Zika, indirect evidence or other topic",Surveillance report or data,,,No,Yes,670,Clinical/epidemiological research,Ecological study/outbreak report
671,"InVS, Point Epidemiologique CIRE Antilles Guyane, 2016",InVS,InVS,Point épidémio: Emergence du virus zika aux Antilles Guyane : Situation épidémiologique - 10 mars 2016,Point Epidemiologique CIRE Antilles Guyane,9,,,2016,2010-present,March 10, 2016,,,2025,French,http://www.invs.sante.fr/fr/Publications-et-outils/Points-epidemiologiques/Tous-les-numeros/Antilles-Guyane/2016/Situation-epidemiologique-du-virus-Zika-aux-Antilles-Guyane.-Point-au-10-mars-2016,,France,Europe,,Public/Government,,,Institute de veille sanitaire,April 11, 2016,Yes,,No,"Zika, indirect evidence or other topic",Surveillance report or data,,,No,Yes,671,Clinical/epidemiological research,Ecological study/outbreak report
672,"Butler, Nature, 2016",Butler,"Butler, D.",First Zika-linked birth defects detected in Colombia,Nature,531,7593,153,2016,2010-present,March 11, 2016,26961637,10.1038/nature.2016.19502,2065,English,,,,,,,"Brazil/epidemiology; Colombia/epidemiology; Epidemiological Monitoring; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases/ diagnosis/ epidemiology/virology; Microcephaly/diagnosis/ epidemiology/ virology; Pregnancy; Zika Virus/ pathogenicity; Zika Virus Infection/ complications/diagnosis/ epidemiology/virology",,Pubmed,April 11, 2016,No,Duplicate of existing record,,,,,,,,,,
673,"Vogel, Science, 2016",Vogel,"Vogel, G.",INFECTIOUS DISEASE. Evidence grows for Zika virus as pregnancy danger,Science,351,6278,1123-4,2016,2010-present,March 12, 2016,26965596,10.1126/science.351.6278.1123,2083,English,http://science.sciencemag.org/content/sci/351/6278/1123.full.pdf,,,,,,"Brain/ abnormalities/ virology; Female; Humans; Infant; Microcephaly/ virology; Pregnancy; Pregnancy Complications, Infectious/ virology; World Health Organization; Zika Virus; Zika Virus Infection/ complications","Since late last year when physicians in Brazil warned that a wave of serious birth defects might be linked to a little-known virus called Zika, researchers have struggled to prove the connection. Some in the media have questioned whether the reported increase in birth defects is real; others, particularly environmental activists, have suggested the virus is an innocent bystander, unfairly blamed for defects caused by chemicals or other factors. With three studies published last week, chances that the virus has been wrongly accused are fading. Two independent groups showed that, at least in the lab, the virus eagerly infects developing brain cells, suggesting a mechanism by which it could cause the most striking of the observed birth defects: microcephaly, in which babies are born with abnormally small heads and brains. A third study, following several dozen pregnant women in Brazil who were infected with the virus, directly links the infection to an increase in brain defects. It also suggests that the virus can harm a developing fetus in other ways, possibly by attacking the placenta and slowing down the supply of nutrients. 'These are the data we have been waiting for,' says Daniel Lucey, an expert on global health at Georgetown University in Washington, D.C.",Pubmed,April 11, 2016,No,Duplicate of existing record,,,,,,,,,,
674,"InVS, Point Epidemiologique CIRE Antilles Guyane, 2016",InVS,InVS,Point épidémio: Emergence du virus zika aux Antilles Guyane : Situation épidémiologique - 17 mars 2016,Point Epidemiologique CIRE Antilles Guyane,10,,,2016,2010-present,March 17, 2016,,,2024,French,http://www.invs.sante.fr/fr/Publications-et-outils/Points-epidemiologiques/Tous-les-numeros/Antilles-Guyane/2016/Situation-epidemiologique-du-virus-Zika-aux-Antilles-Guyane.-Point-au-17-mars-2016,,France,Europe,,Public/Government,,,Institute de veille sanitaire,April 11, 2016,Yes,,No,"Zika, indirect evidence or other topic",Surveillance report or data,,,No,Yes,674,Clinical/epidemiological research,Ecological study/outbreak report
675,"InVS, Point Epidemiologique CIRE Antilles Guyane, 2016",InVS,InVS,Point épidémio: Emergence du virus zika aux Antilles Guyane : Situation épidémiologique - 24 mars 2016,Point Epidemiologique CIRE Antilles Guyane,11,,,2016,2010-present,March 24, 2016,,,2023,French,http://www.invs.sante.fr/fr/Publications-et-outils/Points-epidemiologiques/Tous-les-numeros/Antilles-Guyane/2016/Situation-epidemiologique-du-virus-Zika-aux-Antilles-Guyane.-Point-au-24-mars-2016,,France,Europe,,Public/Government,,,Institute de veille sanitaire,April 11, 2016,Yes,,No,"Zika, indirect evidence or other topic",Surveillance report or data,,,No,Yes,675,Clinical/epidemiological research,Ecological study/outbreak report
676,"Nau, Rev Med Suisse, 2016",Nau,"Nau, J. Y.","[The American Zika epidemic, or the medicine side to religion]",Rev Med Suisse,12,504,282-3,2016,2010-present,March 24, 2016,27000001,,2045,French,,,,,,,"Aedes/virology; Animals; Disease Outbreaks; Female; Humans; Insect Vectors; Pregnancy; Pregnancy Complications, Infectious/ virology; Zika Virus/ isolation & purification; Zika Virus Infection/ epidemiology/virology",,Pubmed,April 11, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,No,Comment/Editorial/Perspective/Letter,No,Yes,676,,
677,"Vogel, Science, 2016",Vogel,"Vogel, G.",INFECTIOUS DISEASE. Don't blame sports for Zika's spread,Science,351,6280,1377-8,2016,2010-present,March 26, 2016,27013706,10.1126/science.351.6280.1377,2084,English,http://science.sciencemag.org/content/351/6280/1377.long; http://science.sciencemag.org/content/sci/351/6280/1377.full.pdf,,,,,,"Brazil/epidemiology; Genome, Viral; Humans; Sports; Travel; Zika Virus/ genetics; Zika Virus Infection/epidemiology/ transmission/ virology","Since the Zika virus began racing through the Americas, scientists have been trying to figure out when and where it entered Brazil, where it was first detected in March 2015. Speculation has focused on the influx of fans for the World Cup in June and July 2014, or for a championship canoe race in September 2014. But a new genome analysis suggests the virus had likely been spreading there long before either event, having arrived sometime between May and December 2013. It could have arrived during the Confederations Cup soccer tournament in late June 2013, the authors say. That event brought the Tahitian national team to a stadium in Recife, near the epicenter of the Brazilian epidemic. But that was several months before cases of Zika were reported in Tahiti, and the authors think it's more fruitful to look at broader travel patterns rather than discrete events. They point out that during 2013, air travel from Zika-endemic areas to Brazil increased by almost 50%, from roughly 3500 passengers arriving per month to nearly 5000.",Pubmed,April 11, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,677,,
678,"Haug, N Engl J Med, 2016",Haug,"Haug, C. J., Kieny, M. P., Murgue, B.",The Zika Challenge,N Engl J Med,,,,2016,2010-present,March 31, 2016,27028782,10.1056/NEJMp1603734,2056,English,,,,,,,,,Pubmed,April 11, 2016,No,Duplicate of existing record,,,,,,,,,,
679,"Maurice, Lancet, 2016",Maurice,"Maurice, J.",WHO meeting thrashes out R&D strategy against Zika,Lancet,387,10024,1147,2016,2010-present,March 31, 2016,27025322,10.1016/s0140-6736(16)30012-5,2106,English,http://ac.els-cdn.com/S0140673616300125/1-s2.0-S0140673616300125-main.pdf?_tid=98acac14-ffbd-11e5-83fc-00000aab0f01&acdnat=1460362728_b7b8059b2d22e9b7ad5050484d24d22a; http://ac.els-cdn.com/S0140673616300125/1-s2.0-S0140673616300125-main.pdf?_tid=d900f9b0-fffd-11e5-ad5f-00000aab0f26&acdnat=1460390323_6cb4965b91d19c4f0a439b64d5c82d3c,,,,,,,,Pubmed,April 11, 2016,No,Duplicate of existing record,,,,,,,,,,
680,"WHO, , 2016",WHO,WHO,"Zika situation report. Zika virus, Microcephaly and Guillain-Barré syndrome - 31 March 2016",,,,,2016,2010-present,March 31, 2016,,,2012,,http://www.who.int/emergencies/zika-virus/situation-report/31-march-2016/en/,,Switzerland,Europe,,Public/Government,,,WHO,April 11, 2016,Yes,,No,"Zika, indirect evidence or other topic",Surveillance report or data,,,No,Yes,680,Clinical/epidemiological research,Ecological study/outbreak report
681,"Bharucha, Neuropathol Appl Neurobiol, 2016",Bharucha,"Bharucha, T.; Breuer, J.",A neglected Flavivirus: An update on Zika virus in 2016 and the future direction of research,Neuropathol Appl Neurobiol,,,,2016,2010-present,April 1, 2016,27029817,10.1111/nan.12326,2145,English,http://onlinelibrary.wiley.com/store/10.1111/nan.12326/asset/nan12326.pdf?v=1&t=imvq5fab&s=15265f1bd9826b1dee0176cc403ab6350cf8bea9; http://onlinelibrary.wiley.com/store/10.1111/nan.12326/asset/nan12326.pdf?v=1&t=imw6ow09&s=af22dc7c983faa2ff94a7c0f549d505f2aad3f9b,University College London.; Royal Free Hospital NHS Foundation Trust.,,,,,Arbovirus; Emerging Infection; Flavivirus; Public health,"The 2015-16 global emergence of Zika virus infection (ZIKV) and its putative link with Guillain-Barre Syndrome and microcephaly, at the tail-end of the Ebola epidemic, has provoked unease throughout the international community. The World Health Organisation (WHO) declared ZIKV a public health emergency on 1st February 2016, but at the time of writing suggest there is still insufficient evidence that ZIKV is independently responsible for any serious complications. Our current understanding of this arthropod-borne Flavivirus is still at an early stage. The first reported human infections were sixty years ago, and until the first outbreak in Micronesia in 2007, there were only fourteen documented cases. Nonetheless there are parallels that we can draw from our understanding of other related arbo-flaviviruses, such as dengue, Japanese encephalitis and West Nile viruses. This article provides a focussed review of the literature on ZIKV to date, with perspectives on the direction of future research. This article is protected by copyright. All rights reserved.",Pubmed,April 11, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Yes,Review,No,Yes,681,Clinical/epidemiological research,Epidemiological/clinical review
682,"McCarthy, BMJ, 2016",McCarthy,"McCarthy, M.","Couples at risk from exposure to Zika virus should consider delaying pregnancy, says CDC",BMJ,352,,i1813,2016,2010-present,April 1, 2016,27029872,10.1136/bmj.i1813,2105,English,http://www.bmj.com/content/bmj/352/bmj.i1813.full.pdf,Seattle.,,,,,,,Pubmed,April 11, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",News item or lay press,,,No,Yes,682,,
683,"ECDC, , 2016",ECDC,ECDC,Epidemiological update. Outbreaks of Zika virus and complication potentially linked to the Zika virus infection - 01 April 2016,,,,,2016,2010-present,April 1, 2016,,,2060,,,,Sweden,Europe,,Public/Government,,,ECDC,April 11, 2016,Yes,,No,"Zika, indirect evidence or other topic",Surveillance report or data,,,No,Yes,683,Clinical/epidemiological research,Ecological study/outbreak report
684,"Tepper, MMWR Morb Mortal Wkly Rep, 2016",Tepper,"Tepper, N. K.; Goldberg, H. I.; Bernal, M. I.; Rivera, B.; Frey, M. T.; Malave, C.; Renquist, C. M.; Bracero, N. J.; Dominguez, K. L.; Sanchez, R. E.; Shapiro-Mendoza, C. K.; Rodriguez, B. R.; Simeone, R. M.; Pesik, N. T.; Barfield, W. D.; Ko, J. Y.; Galang, R. R.; Perez-Padilla, J.; Polen, K. N.; Honein, M. A.; Rasmussen, S. A.; Jamieson, D. J.","Estimating Contraceptive Needs and Increasing Access to Contraception in Response to the Zika Virus Disease Outbreak - Puerto Rico, 2016",MMWR Morb Mortal Wkly Rep,65,12,311-4,2016,2010-present,April 1, 2016,27031817,10.15585/mmwr.mm6512e1,2020,English,,,,,,,,"Zika virus is a flavivirus transmitted primarily by Aedes species mosquitoes. Increasing evidence links Zika virus infection during pregnancy to adverse pregnancy and birth outcomes, including pregnancy loss, intrauterine growth restriction, eye defects, congenital brain abnormalities, and other fetal abnormalities (1,2). The virus has also been determined to be sexually transmitted.* Because of the potential risks associated with Zika virus infection during pregnancy, CDC has recommended that health care providers discuss prevention of unintended pregnancy with women and couples who reside in areas of active Zika virus transmission and do not want to become pregnant.(dagger) However, limitations in access to contraception in some of these areas might affect the ability to prevent an unintended pregnancy. As of March 16, 2016, the highest number of Zika virus disease cases in the United States and U.S. territories were reported from Puerto Rico.( section sign) The number of cases will likely rise with increasing mosquito activity in affected areas, resulting in increased risk for transmission to pregnant women. High rates of unintended and adolescent pregnancies in Puerto Rico suggest that, in the context of this outbreak, access to contraception might need to be improved (3,4). CDC estimates that 138,000 women of reproductive age (aged 15-44 years) in Puerto Rico do not desire pregnancy and are not using one of the most effective or moderately effective contraceptive methods,( paragraph sign)(,)** and therefore might experience an unintended pregnancy. CDC and other federal and local partners are seeking to expand access to contraception for these persons. Such efforts have the potential to increase contraceptive access and use, reduce unintended pregnancies, and lead to fewer adverse pregnancy and birth outcomes associated with Zika virus infection during pregnancy. The assessment of challenges and resources related to contraceptive access in Puerto Rico might be a useful model for other areas with active transmission of Zika virus.",Pubmed,April 11, 2016,Yes,,No,"Zika, not relevant to causality framework",Scientific (journal) article,No,Other,No,Yes,684,,
685,"InVS, Point Epidemiologique CIRE Antilles Guyane, 2016",InVS,InVS,Point épidémio: Emergence du virus zika aux Antilles Guyane : Situation épidémiologique - 01 avril 2016,Point Epidemiologique CIRE Antilles Guyane,12,,,2016,2010-present,April 1, 2016,,,2022,French,http://www.invs.sante.fr/fr/Publications-et-outils/Points-epidemiologiques/Tous-les-numeros/Antilles-Guyane/2016/Situation-epidemiologique-du-virus-Zika-aux-Antilles-Guyane.-Point-au-1er-avril-2016,,France,Europe,,Public/Government,,,Institute de veille sanitaire,April 11, 2016,Yes,,No,"Zika, indirect evidence or other topic",Surveillance report or data,,,No,Yes,685,Clinical/epidemiological research,Ecological study/outbreak report
686,"Kallas, JAMA Pediatr, 2016",Kallas,"Kallas, E. G.; O'Connor, D. H.",Real-Time Sharing of Zika Virus Data in an Interconnected World,JAMA Pediatr,,,,2016,2010-present,April 1, 2016,27031608,10.1001/jamapediatrics.2016.0857,2109,English,http://archpedi.jamanetwork.com/data/Journals/PEDS/0/pvp160011.pdf,"Division of Clinical Immunology and Allergy, University of Sao Paulo Medical School, Sao Paulo, Brazil2Department of Infectious and Parasitic Diseases, University of Sao Paulo Medical School, Sao Paulo, Brazil.; Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison4Wisconsin National Primate Research Center, Madison.",,,,,,,Pubmed,April 11, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,686,,
687,"Justin T Lessler, Bull World Health Organ, 2016",Justin T Lessler,"Justin T Lessler, Cassandara T Ott, Andrea C Carcelen, Jacob M Konikoff, Joe Williamson, Qifang Bi, Lauren M Kucirka, Derek AT Cummings, Nicholas G Reich, Lelia H Chaisson",Times to key events in the course of Zika infection and their implications: a systematic review and pooled analysis,Bull World Health Organ,,,,2016,2010-present,April 1, 2016,,10.2471/BLT.16.174540,2110,,http://www.who.int/bulletin/online_first/16-174540.pdf,,,,,,,,WHO Zika open,April 11, 2016,No,Duplicate of existing record,,,,,,,,,,
688,"Petersen, MMWR Morb Mortal Wkly Rep, 2016",Petersen,"Petersen, E. E.; Polen, K. N.; Meaney-Delman, D.; Ellington, S. R.; Oduyebo, T.; Cohn, A.; Oster, A. M.; Russell, K.; Kawwass, J. F.; Karwowski, M. P.; Powers, A. M.; Bertolli, J.; Brooks, J. T.; Kissin, D.; Villanueva, J.; Munoz-Jordan, J.; Kuehnert, M.; Olson, C. K.; Honein, M. A.; Rivera, M.; Jamieson, D. J.; Rasmussen, S. A.","Update: Interim Guidance for Health Care Providers Caring for Women of Reproductive Age with Possible Zika Virus Exposure - United States, 2016",MMWR Morb Mortal Wkly Rep,65,12,315-22,2016,2010-present,April 1, 2016,27031943,10.15585/mmwr.mm6512e2,2040,English,,,,,,,,"CDC has updated its interim guidance for U.S. health care providers caring for women of reproductive age with possible Zika virus exposure (1) to include recommendations on counseling women and men with possible Zika virus exposure who are interested in conceiving. This guidance is based on limited available data on persistence of Zika virus RNA in blood and semen (2-5). Women who have Zika virus disease* should wait at least 8 weeks after symptom onset to attempt conception, and men with Zika virus disease should wait at least 6 months after symptom onset to attempt conception. Women and men with possible exposure to Zika virus but without clinical illness consistent with Zika virus disease should wait at least 8 weeks after exposure to attempt conception. Possible exposure to Zika virus is defined as travel to or residence in an area of active Zika virus transmission (http://www.cdc.gov/zika/geo/active-countries.html), or sex (vaginal intercourse, anal intercourse, or fellatio) without a condom with a man who traveled to or resided in an area of active transmission. Women and men who reside in areas of active Zika virus transmission should talk with their health care provider about attempting conception. This guidance also provides updated recommendations on testing of pregnant women with possible Zika virus exposure. These recommendations will be updated when additional data become available.",Pubmed,April 11, 2016,No,Duplicate of existing record,,,,,,,,,,
689,"Oster, MMWR Morb Mortal Wkly Rep, 2016",Oster,"Oster, A. M.; Russell, K.; Stryker, J. E.; Friedman, A.; Kachur, R. E.; Petersen, E. E.; Jamieson, D. J.; Cohn, A. C.; Brooks, J. T.","Update: Interim Guidance for Prevention of Sexual Transmission of Zika Virus - United States, 2016",MMWR Morb Mortal Wkly Rep,65,12,323-5,2016,2010-present,April 1, 2016,27032078,10.15585/mmwr.mm6512e3,2043,English,,,,,,,,"CDC issued interim guidance for the prevention of sexual transmission of Zika virus on February 5, 2016 (1). The following recommendations apply to men who have traveled to or reside in areas with active Zika virus transmission* and their female or male sex partners. These recommendations replace the previously issued recommendations and are updated to include time intervals after travel to areas with active Zika virus transmission or after Zika virus infection for taking precautions to reduce the risk for sexual transmission. This guidance defines potential sexual exposure to Zika virus as any person who has had sex (i.e., vaginal intercourse, anal intercourse, or fellatio) without a condom with a man who has traveled to or resides in an area with active Zika virus transmission. This guidance will be updated as more information becomes available.",Pubmed,April 11, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,No,Other,No,Yes,689,,
690,"Logan, Biorxiv, 2016",Logan,"Logan, I.S.",ZIKA-How fast does this virus mutate?,Biorxiv,37,2,110-5,2016,2010-present,April 1, 2016,27029869,10.13918/j.issn.2095-8137.2016.2.110,2054,English,,"Parkside Drive, Exmouth, Devon, UK EX8 4LB. ianlogan22@btinternet.com.",,,,,Mutation rate; Phylogenetic tree; Polyprotein; Virus; Zika,"The World Health Organization has declared the present Zika virus epidemic to be a 'Public Health Emergency of International Concern'. The virus appears to have spread from Thailand to French Polynesia in 2013, and has since infected over a million people in the countries of South and Central America. In most cases the infection is mild and transient, but the virus does appear to be strongly neurotropic and the presumptive cause of both birth defects in fetuses and Guillain-Barre syndrome in some adults. In this paper, the techniques and utilities developed in the study of mitochondrial DNA were applied to the Zika virus. As a result, it is possible to show in a simple manner how a phylogenetic tree may be constructed and how the mutation rate of the virus can be measured. The study showed the mutation rate to vary between 12 and 25 bases a year, in a viral genome of 10272 bases. This rapid mutation rate will enable the geographic spread of the epidemic to be monitored easily and may also prove useful in assisting the identification of preventative measures that are working, and those that are not.",Pubmed,April 11, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,No,Original research,No,Yes,690,Basic and applied biomedical research,Sequence analysis and phylogenetics
691,"Korzeniewski K Warsaw, Int Marit Health, 2016",Korzeniewski K Warsaw,"Korzeniewski K Warsaw, Poland kktropmed wp pl; Juszczak, D.; Zwolinska, E.",Zika - another threat on the epidemiological map of the world,Int Marit Health,67,1,31. Jul,2016,2010-present,April 1, 2016,27029927,10.5603/imh.2016.0007,2053,English,,,,,,,Zika virus; clinical symptoms; epidemiology; prevention,"Zika fever is an acute infectious disease caused by the Zika virus (ZIKV) of the Flaviviridae family and Flavivirus genus. It is transmitted by day-time active Aedes mosquitoes, and potentially by sexual contacts, blood transfusion, and from mother to foetus (resulting in microcephaly in a child). ZIKV was first isolated from a macaque monkey in the Zika forest in Uganda in 1947. The first case of the Zika fever in a human was recorded in Nigeria in 1954. Until 2007 only 14 cases of the disease were confirmed worldwide. In 2007, there was an outbreak of the Zika fever in Micronesia (Yap Island) with an estimated 5,000 cases. Between 2013 and 2015 a further outbreak of the disease occurred in the Pacific islands: in French Polynesia, New Caledonia, Cook Islands, Easter Island, and Solomon Islands. In 2015, the Zika fever spread to Brazil and more than 20 other countries in the South and Central America. Until March 2016, an estimated 1.6 million autochthonous cases of Zika have been reported globally, with approximately 1.5 million cases recorded in Brazil. Typically, 80% of Zika infections are asymptomatic. The most common symptoms of the disease include fever, maculopapular rash, muscle and joint pain, conjunctivitis. Zika fever can be diagnosed on the basis of clinical signs (it must be differentiated from dengue, chikungunya), ZIKV identification is also possible by the application of polymerase chain reaction in acutely ill patients and the detection of specific IgM and IgG antibodies to ZIKV. Until today, there is no effective antiviral treatment or an effective vaccine against Zika fever (in case of an infection only symptomatic treatment is applied). In August 2016 in Rio de Janeiro (Brazil) Summer Olympic Games will take place, attracting thousands of athletes and spectators. The fight against the Zika fever and the race against time have gained momentum.",Pubmed,April 11, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,691,,
692,"Musso, Clin Microbiol Rev, 2016",Musso,"Musso, D.; Gubler, D. J.",Zika Virus,Clin Microbiol Rev,29,3,487-524,2016,2010-present,April 1, 2016,27029595,10.1128/cmr.00072-15,2102,English,http://cmr.asm.org/content/29/3/487.full.pdf,"Unit of Emerging Infectious Diseases, Institut Louis Malarde, Tahiti, French Polynesia dmusso@ilm.pf duane.gubler@duke-nus.edu.sg.; Program in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore Partnership for Dengue Control, Lyon, France dmusso@ilm.pf duane.gubler@duke-nus.edu.sg.",,,,,,"Zika virus (ZIKV) is an arthropod-borne virus (arbovirus) in the genus Flavivirus and the family Flaviviridae. ZIKV was first isolated from a nonhuman primate in 1947 and from mosquitoes in 1948 in Africa, and ZIKV infections in humans were sporadic for half a century before emerging in the Pacific and the Americas. ZIKV is usually transmitted by the bite of infected mosquitoes. The clinical presentation of Zika fever is nonspecific and can be misdiagnosed as other infectious diseases, especially those due to arboviruses such as dengue and chikungunya. ZIKV infection was associated with only mild illness prior to the large French Polynesian outbreak in 2013 and 2014, when severe neurological complications were reported, and the emergence in Brazil of a dramatic increase in severe congenital malformations (microcephaly) suspected to be associated with ZIKV. Laboratory diagnosis of Zika fever relies on virus isolation or detection of ZIKV-specific RNA. Serological diagnosis is complicated by cross-reactivity among members of the Flavivirus genus. The adaptation of ZIKV to an urban cycle involving humans and domestic mosquito vectors in tropical areas where dengue is endemic suggests that the incidence of ZIKV infections may be underestimated. There is a high potential for ZIKV emergence in urban centers in the tropics that are infested with competent mosquito vectors such as Aedes aegypti and Aedes albopictus.",Pubmed,April 11, 2016,Yes,,No,"Zika, indirect evidence or other topic",Scientific (journal) article,Yes,Review,No,Yes,692,Clinical/epidemiological research,Epidemiological/clinical review
693,"Al-Qahtani, J Infect Dev Ctries, 2016",Al-Qahtani,"Al-Qahtani, A. A.; Nazir, N.; Al-Anazi, M. R.; Rubino, S.; Al-Ahdal, M. N.",Zika virus: a new pandemic threat,J Infect Dev Ctries,10,3,201-7,2016,2010-present,April 1, 2016,27031450,10.3855/jidc.8350,2150,English,http://www.jidc.org/index.php/journal/article/download/27031450/1467,"King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia. aqahtani@kfshrc.edu.sa.",,,,,,"Zika virus (ZIKV) is an emerging arbovirus of the Flaviviridae family and is related to dengue, Chikungunya, West Nile, yellow fever, and Japanese encephalitis viruses. ZIKV was first discovered in Uganda in 1947. Different species of mosquito from the Aedes genus, mainly A. aegypti and A. albopictus are the vectors responsible for ZIKV infection in humans. It is also reported that ZIKV is transmitted congenitally, sexually, and through blood donation. Until recently, ZIKV outbreaks were sporadic and self-limiting. The first large epidemic was reported from Yap Island in 2007 followed by an outbreak of Zika fever in French Polynesia in 2013. Brazil is the epicenter of the current ZIKV epidemic which is rapidly spreading across the Americas. ZIKV infection remained relatively less studied in view of its low case numbers, and low clinical impact relative to other arboviruses. However, all this is set to change with its rapid spread in the Western hemisphere and suspected complications particularly microcephaly in newborn babies with ZIKV infected mothers. ZIKV is expected to substantially add to both short-term and long-term economic burden of the effected countries. Due to the large number of people travelling across the borders and some reported cases of transmission of ZIKV via contaminated blood, screening and identification of asymptomatic infected individuals are important.",Pubmed,April 11, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Yes,Review,No,Yes,693,Clinical/epidemiological research,Epidemiological/clinical review
694,"Nandy, Curr Comput Aided Drug Des, 2016",Nandy,"Nandy, A.; Dey, S.; Basak, S. C.; Bielinska-Waz, D.; Waz, P.",Characterizing the Zika virus genome - A bioinformatics study,Curr Comput Aided Drug Des,,,,2016,2010-present,April 2, 2016,27032927,,2046,English,,"Centre for Interdisciplinary Research and Education, 404B Jodhpur Park, Kolkata 700068, INDIA. anandy43@yahoo.com.",,,,,,"The recent epidemic of Zika virus infections in South and Latin America have raised serious concern on its ramifications for the population in the Americas and spread of the virus worldwide. The Zika virus disease is a relatively new phenomenon for which sufficient and comprehensive data and investigative reports have not been available to date. We have done a bioinformatics study of the available genomic sequences of the Zika viruses and characterize the virus in terms of various biological properties of interest like phylogenetic relationships, transition-transversion ratios, amino acid usage, codon usage bias and hydropathy index. We also show the remarkable differences in base distributions of the African and non-African genomes in a 2D graphical representation and compute sequence parameters and descriptors that highlight the marked differences that characterize the sequences of the two groups. These findings are important for computer-assisted approaches towards surveillance and consequent design of drugs and vaccines to combat the growth and spread of the Zika virus.",Pubmed,April 11, 2016,Yes,,No,"Zika, indirect evidence or other topic",Scientific (journal) article,Yes,Original research,No,Yes,694,Basic and applied biomedical research,Sequence analysis and phylogenetics
695,"Koenig, Disaster Med Public Health Prep, 2016",Koenig,"Koenig, K. L.",Quarantine for Zika Virus? Where is the Science?,Disaster Med Public Health Prep,,,01. Mrz,2016,2010-present,April 2, 2016,27032458,10.1017/dmp.2016.56,2108,English,http://journals.cambridge.org/download.php?file=%2FDMP%2FS1935789316000562a.pdf&code=7c6dbf8a043c5cfb3d961c531b3262e2; http://journals.cambridge.org/download.php?file=%2FDMP%2FS1935789316000562a.pdf&code=ec29edf6f6de1c009f1f376d4cb1ef35,"Center for Disaster Medical Sciences,University of California at Irvine,Orange,California.",,,,,Ebola; Zika; health policy; isolation; quarantine,"In January 2016, the World Health Organization warned that Zika virus is be present worldwide within a year. Soon thereafter, some politicians and authors publicly advocated for quarantine of travelers returning from regions where mosquitoes carrying Zika virus are prevalent. The public health tool of quarantine can be used to prevent the spread of infection by restricting the movement of persons who have been exposed to a deadly disease that can be transmitted from person to person before symptom onset. With 80% of Zika virus infections being asymptomatic, no rapid test being available to detect the virus, and primary transmission being via the bites of certain mosquitoes, application of quarantine in this setting is not scientifically sound or practically feasible. Rather, public health interventions should focus on preventing bites from infected mosquitoes, counseling pregnant women on the risks of fetal microcephaly and other birth defects, and identifying patients with signs and symptoms of Guillain-Barre syndrome. As was seen in the Ebola virus disease outbreak of 2014, non-evidence-based factors can influence policy decisions. Public health experts must ensure that policy makers are informed that quarantine is not a scientifically sound approach for the control of Zika virus. (Disaster",Pubmed,April 11, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,695,,
696,"Sirohi, Science, 2016",Sirohi,"Sirohi, D.; Chen, Z.; Sun, L.; Klose, T.; Pierson, T. C.; Rossmann, M. G.; Kuhn, R. J.",The 3.8 A resolution cryo-EM structure of Zika virus,Science,,,,2016,2010-present,April 2, 2016,27033547,10.1126/science.aaf5316,2088,English,http://science.sciencemag.org/content/sci/early/2016/04/01/science.aaf5316.full.pdf,"Markey Center for Structural Biology and Purdue Institute for Inflammation, Immunology and Infectious Disease, Purdue University, West Lafayette, IN 47907, USA.; Viral Pathogenesis Section, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.",,,,Public/Government,,"The recent rapid spread of Zika virus and its unexpected linkage to birth defects and an autoimmune-neurological syndrome has generated worldwide concern. Zika virus is a flavivirus like dengue, yellow fever and West Nile viruses. We present the 3.8A resolution structure of mature Zika virus determined by cryo-electron microscopy. The structure of Zika virus is similar to other known flavivirus structures except for the ~10 amino acids that surround the Asn154 glycosylation site found in each of the 180 envelope glycoproteins that make up the icosahedral shell. The carbohydrate moiety associated with this residue, recognizable in the cryo-EM electron density, may function as an attachment site of the virus to host cells. This region varies not only among Zika virus strains but also in other flaviviruses and suggests that changes in this region influence virus transmission and disease.",Pubmed,April 11, 2016,Yes,,No,"Zika, indirect evidence or other topic",Scientific (journal) article,Yes,Original research,No,Yes,696,Basic and applied biomedical research,Biochemical/protein structure studies
697,"Kronborg, Ugeskr Laeger, 2016",Kronborg,"Kronborg, G.; Fomsgaard, A.",[Zika virus epidemic],Ugeskr Laeger,178,12,,2016,2010-present,April 2, 2016,27032431,,2052,Other,,gkronborg@dadlnet.dk.,,,,,,"Zika virus is endemic in several parts of the world. February 1, 2016 Zika virus was declared a public health emergency by the WHO. This declaration is mainly due to a convincing association between Zika virus infection during pregnancy and birth defects, like microcephaly, among some of the newborns. Imported cases of Zika virus infection to North America, Europe and Denmark have been described. The infection in itself is mild and self-limiting. The available diagnostic methods are under development, validation and evaluation. In Denmark, some promising diagnostics are available at Statens Serum Institut.",Pubmed,April 11, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,697,,
698,"Vial Claro, Rev Chil Pediatr, 2016",Vial Claro,"Vial Claro, P. A.; Araos Bralic, R. I.",[Zika virus in a New World],Rev Chil Pediatr,,,,2016,2010-present,April 2, 2016,27032485,10.1016/j.rchipe.2016.02.005,2085,Spanish,http://ac.els-cdn.com/S0370410616000310/1-s2.0-S0370410616000310-main.pdf?_tid=8bb0d058-ffbd-11e5-8650-00000aab0f26&acdnat=1460362706_a536c9dd4e538fd78c8dcfc104f564f4; http://ac.els-cdn.com/S0370410616000310/1-s2.0-S0370410616000310-main.pdf?_tid=9747cac6-fffd-11e5-8196-00000aab0f26&acdnat=1460390213_fac65cdf46bcf631fb47cbd440a6d7e1,"Instituto de Ciencias e Innovacion en Medicina, Facultad de Medicina, Clinica Clinica Alemana de Santiago, Santiago, Chile. Electronic address: pvial@udd.cl.; Instituto de Ciencias e Innovacion en Medicina, Facultad de Medicina, Clinica Clinica Alemana de Santiago, Santiago, Chile.",,,,,,,Pubmed,April 11, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,698,,
699,"de Oliveira, J Pediatr (Rio J), 2016",de Oliveira,"de Oliveira, C. S.; da Costa Vasconcelos, P. F.",Microcephaly and Zika virus,J Pediatr (Rio J),92,2,103-5,2016,2010-present,April 3, 2016,27036749,10.1016/j.jped.2016.02.003,2121,English,http://ac.els-cdn.com/S0021755716000395/1-s2.0-S0021755716000395-main.pdf?_tid=85ba9558-ffbd-11e5-98ba-00000aab0f6c&acdnat=1460362696_2cbb36bb1272d94504f535e69f149cf8; http://ac.els-cdn.com/S0021755716000395/1-s2.0-S0021755716000395-main.pdf?_tid=0c61b736-fffe-11e5-a462-00000aab0f01&acdnat=1460390409_a622ca490f55711f22489dd864d7f9f6,"Section of Arbovirology and Hemorrhagic Fevers, Instituto Evandro Chagas (IEC), Secretaria de Vigilancia em Saude (SVS), Ministerio da Saude (MS), Ananindeua, address: consuelooliveira@iec.pa.gov.br.; Section of Arbovirology and Hemorrhagic Fevers, Instituto Evandro Chagas (IEC), Secretaria de Vigilancia em Saude (SVS), Ministerio da Saude (MS), Ananindeua, Reference in Arbovirus, World Health Organization (WHO) Collaborating Center, Organizacao Pan-Americana da Saude (OPAS), Brasilia, DF, Brazil.",,,,,,,Pubmed,April 11, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,699,,
700,"Fan, Wiley Interdiscip Rev Nanomed Nanobiotechnol, 2016",Fan,"Fan, Y.; Moon, J. J.",Particulate delivery systems for vaccination against bioterrorism agents and emerging infectious pathogens,Wiley Interdiscip Rev Nanomed Nanobiotechnol,,,,2016,2010-present,April 3, 2016,27038091,10.1002/wnan.1403,2118,English,http://onlinelibrary.wiley.com/store/10.1002/wnan.1403/asset/wnan1403.pdf?v=1&t=imvq4yy0&s=c0f8ebbaa43ec761044403ceb00873fdf62703cc; http://onlinelibrary.wiley.com/store/10.1002/wnan.1403/asset/wnan1403.pdf?v=1&t=imw6mjqc&s=ef2d7262badbc0031552ec83121cd30a539e25a6,"Department of Pharmaceutical Sciences, University of Michigan, Ann Arbor, MI, USA.; Biointerfaces Institute, University of Michigan, Ann Arbor, MI, USA.; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA.",,,,,,"Bioterrorism agents that can be easily transmitted with high mortality rates and cause debilitating diseases pose major threats to national security and public health. The recent Ebola virus outbreak in West Africa and ongoing Zika virus outbreak in Brazil, now spreading throughout Latin America, are case examples of emerging infectious pathogens that have incited widespread fear and economic and social disruption on a global scale. Prophylactic vaccines would provide effective countermeasures against infectious pathogens and biological warfare agents. However, traditional approaches relying on attenuated or inactivated vaccines have been hampered by their unacceptable levels of reactogenicity and safety issues, whereas subunit antigen-based vaccines suffer from suboptimal immunogenicity and efficacy. In contrast, particulate vaccine delivery systems offer key advantages, including efficient and stable delivery of subunit antigens, co-delivery of adjuvant molecules to bolster immune responses, low reactogenicity due to the use of biocompatible biomaterials, and robust efficiency to elicit humoral and cellular immunity in systemic and mucosal tissues. Thus, vaccine nanoparticles and microparticles are promising platforms for clinical development of biodefense vaccines. In this review, we summarize the current status of research efforts to develop particulate vaccine delivery systems against bioterrorism agents and emerging infectious pathogens. For further resources related to this article, please visit the WIREs website.",Pubmed,April 11, 2016,Yes,,No,"Zika, not relevant to causality framework",Scientific (journal) article,Yes,Review,No,Yes,700,Clinical/epidemiological research,Epidemiological/clinical review
701,"Rathore, Pediatr Rev, 2016",Rathore,"Rathore, M. H.",Zika Virus - Pediatricians Be Aware,Pediatr Rev,37,4,133-4,2016,2010-present,April 3, 2016,27037098,10.1542/pir.2016-0003,2037,English,http://pedsinreview.aappublications.org/content/37/4/133?variant=long&sso=1&sso_redirect_count=1&nfstatus=401&nftoken=00000000-0000-0000-0000-000000000000&nfstatusdescription=ERROR%3a+No+local+token,"Editorial Board member University of Florida Center for HIV/AIDS Research, Education and Service (UF CARES) Jacksonville, FL.",,,,,,"Every few years, a 'new' (not really) funny-sounding infectious disease is in the news and causing anxiety: first it was SARS (severe acute respiratory syndrome), then avian flu, swine flu, dengue, MERS (Middle East respiratory syndrome), chikungunya, Ebola, and now in 2016 it's Zika virus. ",Pubmed,April 11, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,701,,
702,"Nowakowski, Cell Stem Cell, 2016",Nowakowski,"Nowakowski, T. J.; Pollen, A. A.; Di Lullo, E.; Sandoval-Espinosa, C.; Bershteyn, M.; Kriegstein, A. R.",Expression Analysis Highlights AXL as a Candidate Zika Virus Entry Receptor in Neural Stem Cells,Cell Stem Cell,,,,2016,2010-present,April 4, 2016,27038591,10.1016/j.stem.2016.03.012,2101,English,http://ac.els-cdn.com/S1934590916001181/1-s2.0-S1934590916001181-main.pdf?_tid=87ecf1c2-ffbd-11e5-8de6-00000aacb35d&acdnat=1460362700_83808918f0029f59bf83e8287570d540; http://ac.els-cdn.com/S1934590916001181/1-s2.0-S1934590916001181-main.pdf?_tid=d417124a-fffd-11e5-82c4-00000aab0f6c&acdnat=1460390315_a557d4b8e459d0d24269e7b528340e6f,"Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, of Neurology, University of California, San Francisco, San Francisco, CA 94158, USA.; Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, of Neurology, University of California, San Francisco, San Francisco, CA 94158, USA. Electronic address: kriegsteina@stemcell.ucsf.edu.",United States,Americas,United States,Mixed,,"The recent outbreak of Zika virus (ZIKV) in Brazil has been linked to substantial increases in fetal abnormalities and microcephaly. However, information about the underlying molecular and cellular mechanisms connecting viral infection to these defects remains limited. In this study we have examined the expression of receptors implicated in cell entry of several enveloped viruses including ZIKV across diverse cell types in the developing brain. Using single-cell RNA-seq and immunohistochemistry, we found that the candidate viral entry receptor AXL is highly expressed by human radial glial cells, astrocytes, endothelial cells, and microglia in developing human cortex and by progenitor cells in developing retina. We also show that AXL expression in radial glia is conserved in developing mouse and ferret cortex and in human stem cell-derived cerebral organoids, highlighting multiple experimental systems that could be applied to study mechanisms of ZIKV infectivity and effects on brain development.",Pubmed,April 11, 2016,Yes,,Yes,,Scientific (journal) article,Yes,Original research,No,Yes,702,Basic and applied biomedical research,In vitro experiment
703,"Burattini, Epidemiol Infect, 2016",Burattini,"Burattini, M. N.; Coutinho, F. A.; Lopez, L. F.; Ximenes, R.; Quam, M.; Wilder-Smith, A.; Massad, E.","Potential exposure to Zika virus for foreign tourists during the 2016 Carnival and Olympic Games in Rio de Janeiro, Brazil",Epidemiol Infect,,,01. Mrz,2016,2010-present,April 5, 2016,27040593,10.1017/s0950268816000649,2142,English,http://journals.cambridge.org/download.php?file=%2FHYG%2FS0950268816000649a.pdf&code=85c211add23b23fb7005a5003ed21b36; http://journals.cambridge.org/download.php?file=%2FHYG%2FS0950268816000649a.pdf&code=53010652ff482744535dff80e4f96db5,"School of Medicine,University of Sao Paulo,SP,Brazil.; Epidemiology and Global Health,Umea University,Umea,Sweden.; Lee Kong Chian School of Medicine,Nanyang,Singapore,Technological University,Singapore,Singapore.",,,,,,,Pubmed,April 11, 2016,Yes,,No,"Zika, not relevant to causality framework",Scientific (journal) article,Yes,Original research,No,Yes,703,Clinical/epidemiological research,Modelling study
704,"Filho, Pest Manag Sci, 2016",Filho,"Filho, L. C.; de Souza, T. M.; Tabosa, P. M.; Soares, N. G.; Rocha-Bezerra, L. C.; Vasconcelos, I. M.; Carvalho, A. F.","Trypsin inhibitor from Leucaena leucocephala seeds delays and disrupts the development of Aedes aegypti, a multiple disease vector",Pest Manag Sci,,,,2016,2010-present,April 5, 2016,27040615,10.1002/ps.4284,2117,English,http://onlinelibrary.wiley.com/store/10.1002/ps.4284/asset/ps4284.pdf?v=1&t=imw5jd5s&s=813c3beb00ea3a780cc325c37633f0a88dfb7054; http://onlinelibrary.wiley.com/store/10.1002/ps.4284/asset/ps4284.pdf?v=1&t=imw6mdxe&s=8b5bf704255e2c59919c29edffd43b3695495ab3,"Federal University of Ceara, Biochemistry and Molecular Biology Department, Pici Campus, 60440-970, Fortaleza, Ceara, Brazil.; Federal University of Ceara, Biology Department, Pici Campus, 60440-900.",,,,,Leucaena; dengue; legume seeds; midgut enzymes; protease inhibitors; zika,"BACKGROUND: Nowadays Aedes aegypti mosquito represents a serious issue in public health due to the large outbreaks of the arboviral diseases Zika, Dengue, Chikungunya and Yellow fever. This holometabolous insect has midgut digestive enzymes which are trypsin and chymotrypsin-like proteins. Protease inhibitors are able to bind to proteolytic enzymes and promote a blockage in digestion and nutrition leading to death. Thus, we investigated the effect of trypsin inhibitor of Leucaena leucocephala (LTI) seeds upon egg hatching, larval development and digestive midgut proteases. RESULTS: LTI was obtained by TCA-precipitation followed by a single chromatography step on anhydrous trypsin sepharose. SDS-PAGE showed a single protein band with molecular mass near 20 kDa. After exposure of Ae. aegypti egg to LTI (0.3 mg.mL-1 ), egg hatching was reduced (50%). LTI did not show acute toxicity on newly hatched larvae incubated under the same conditions, but after ten days of exposure a high mortality rate (86%) was observed and the surviving larvae had a 25% delay in development. LTI was able to inhibit in vitro the midgut enzymatic activity (70%) and when larvae were incubated with LTI solution we observed an inhibition of 56%. CONCLUSIONS: LTI is a promising new tool to control critical points of Ae. aegypti development.",Pubmed,April 11, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Original research,No,Yes,704,Environmental and vector research,Other ecological
705,"Poland, Curr Opin Virol, 2016",Poland,"Poland, GA; Whitaker, JA; Poland, CM; Ovsyannikova, IG; Kennedy, RB",Vaccinology in the third millennium: scientific and social challenges,Curr Opin Virol,17,,116-125,2016,2010-present,April 5, 2016,27039875,10.1016/j.coviro.2016.03.003,2099,English,http://ac.els-cdn.com/S1879625716300189/1-s2.0-S1879625716300189-main.pdf?_tid=c2909086-fff9-11e5-b248-00000aab0f27&acdnat=1460388568_7614af2bb7de239d4be265888724a5a2; http://ac.els-cdn.com/S1879625716300189/1-s2.0-S1879625716300189-main.pdf?_tid=cf1465e0-fffd-11e5-9a82-00000aab0f02&acdnat=1460390307_554c2f4f75d07851207411baf312a71b,"Clinic Division of General Internal Medicine, Mayo Clinic Rochester M. N. U. S. A. Electronic address poland gregory mayo edu; Whitaker Ja Clinic Division of General Internal Medicine, Mayo Clinic Rochester M. N. U. S. A.; Poland, C. M.; Ovsyannikova Ig Clinic Division of General Internal Medicine, Mayo Clinic Rochester M. N. U. S. A.; Kennedy Rb Clinic Division of General Internal Medicine, Mayo Clinic Rochester M. N. U. S. A.      Taylor University Counseling Center, Taylor University, Upland, IN 46989, USA.",,,,,,"The epidemiology of deaths due to vaccine-preventable diseases has been significantly and positively altered through the use of vaccines. Despite this, significant challenges remain in vaccine development and use in the third millennium. Both new (Ebola, Chikungunya, Zika, and West Nile) and re-emerging diseases (measles, mumps, and influenza) require the development of new or next-generation vaccines. The global aging of the population, and accumulating numbers of immunocompromised persons, will require new vaccine and adjuvant development to protect large segments of the population. After vaccine development, significant challenges remain globally in the cost and efficient use and acceptance of vaccines by the public. This article raises issues in these two areas and suggests a way forward that will benefit current and future generations.",Pubmed,April 11, 2016,Yes,,No,Unrelated to Zika virus,Scientific (journal) article,Yes,Review,No,Yes,705,Clinical/epidemiological research,Epidemiological/clinical review
706,"Sanchez Carnerero, Semergen, 2016",Sanchez Carnerero,"Sanchez Carnerero, C. I.; Alcantara Montero, A.",[Provisional considerations about Zika virus infection in pregnant women: Document for health professionals],Semergen,,,,2016,2010-present,April 5, 2016,27041640,10.1016/j.semerg.2016.02.010,2091,Spanish,http://ac.els-cdn.com/S1138359316000903/1-s2.0-S1138359316000903-main.pdf?_tid=bcd0dd90-fff9-11e5-9a2f-00000aab0f02&acdnat=1460388558_f6fe695822124e9cdd2094f3db79af86; http://ac.els-cdn.com/S1138359316000903/1-s2.0-S1138359316000903-main.pdf?_tid=b85a2f2e-fffd-11e5-89ab-00000aab0f01&acdnat=1460390269_801ec93b741d27506cd558241032ccfa,"Servicio de Cirugia General y Digestiva, Hospital San Pedro de Alcantara, Caceres, Espana.; Centro de Salud Jose Maria Alvarez, Don Benito, Badajoz, Espana. Electronic address: a.alcantara.montero@hotmail.com.",,,,,,,Pubmed,April 11, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,706,,
707,"Traynor, Am J Health Syst Pharm, 2016",Traynor,"Traynor, K.",Public health officials alarmed at spread of Zika virus,Am J Health Syst Pharm,73,8,508-9,2016,2010-present,April 6, 2016,27045056,10.2146/news160023,2018,English,http://www.ajhp.org/content/73/8/508.long?hw-tma-check=true,,,,,,,,Pubmed,April 11, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",News item or lay press,,,No,Yes,707,,
708,"Rey, Med Sante Trop, 2016",Rey,"Rey, J. L.; Milleliri, J. M.",The double standard: Zika,Med Sante Trop,26,1,06. Jul,2016,2010-present,April 6, 2016,27046925,10.1684/mst.2016.0559,2097,English,http://www.jle.com/download/mst-306859-deux_poids_deux_mesures_zika-usb1-VwvCD38AAQEAABMBepcAAAAP-u.pdf; http://www.jle.com/download/mst-306859-deux_poids_deux_mesures_zika-usb1-VwvI5X8AAQEAAD9DBUQAAAAH-u.pdf,"Groupe d'intervention en sante publique et en epidemiologie (Gispe) 82 Bd Tellene, 13007 Marseille www.gispe.org.",,,,,,,Pubmed,April 11, 2016,Yes,,No,"Zika, indirect evidence or other topic",Scientific (journal) article,Yes,Review,No,Yes,708,Clinical/epidemiological research,Epidemiological/clinical review
709,"McCarthy, BMJ, 2016",McCarthy,"McCarthy, M.","Vectors for Zika virus may spread further than was previously thought, CDC reports",BMJ,353,,i1914,2016,2010-present,April 6, 2016,27044278,10.1136/bmj.i1914,2104,English,http://www.bmj.com/content/bmj/353/bmj.i1914.full.pdf,Seattle.,,,,,,,Pubmed,April 11, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",News item or lay press,,,No,Yes,709,,
710,"Burnett, J Spec Oper Med, 2016",Burnett,"Burnett, M. W.",Zika Virus,J Spec Oper Med,16,1,86-7,2016,2010-present,April 6, 2016,27045503,,2066,English,,,,,,,,,Pubmed,April 11, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,710,,
711,"Sampathkumar, Mayo Clin Proc, 2016",Sampathkumar,"Sampathkumar, P.; Sanchez, J. L.",Zika Virus in the Americas: A Review for Clinicians,Mayo Clin Proc,91,4,514-21,2016,2010-present,April 6, 2016,27046524,10.1016/j.mayocp.2016.02.017,2092,English,http://ac.els-cdn.com/S0025619616001488/1-s2.0-S0025619616001488-main.pdf?_tid=b75e3b46-fff9-11e5-b490-00000aacb362&acdnat=1460388549_9fe5722a6bb38025d242372a097290f5; http://ac.els-cdn.com/S0025619616001488/1-s2.0-S0025619616001488-main.pdf?_tid=ba730628-fffd-11e5-be0f-00000aacb361&acdnat=1460390272_7ce481f8ec9c38d62878f2e8078132c9,"Division of Infectious Diseases, Mayo Clinic, Rochester, MN. Electronic address: sampathkumar.priya@mayo.edu.; Division of Infectious Diseases, Mayo Clinic, Rochester, MN.",,,,,,"Zika virus has recently emerged as a new public health threat. An arthropod-borne virus named after the Zika forest in Uganda, it was first discovered in 1947. The virus caused only sporadic cases of Zika infection in Africa and Southeast Asia until 2007, when the first large outbreak occurred in the Yap State in the Federated States of Micronesia. Another outbreak in French Polynesia in 2013 was notable for being associated temporally with an increase in cases of Guillain-Barre syndrome. In 2015, the virus was first reported in Brazil and since then has spread explosively through several additional countries in South and Central America and the Caribbean. Simultaneously, several of these countries have seen a dramatic increase in the incidence of infants born with microcephaly. The rapid spread of Zika virus through the Americas, together with the association of infection with microcephaly and Guillain-Barre syndrome, has resulted in the World Health Organization declaring a public health emergency. Zika virus has the potential to spread to new areas where the Aedes mosquito vector is present and therefore presents a risk to the United States. This concise review describes the clinical features of Zika virus infection and provides advice for clinicians on counseling travelers and others about the disease.",Pubmed,April 11, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Yes,Review,No,Yes,711,Clinical/epidemiological research,Epidemiological/clinical review
712,"Demshar, Fla Nurse, 2016",Demshar,"Demshar, J.",There's a New 'Bug' in Town: What You Need to Know About the Zika Virus,Fla Nurse,64,1,10,2016,2010-present,April 7, 2016,27048000,,2063,English,,,,,,,,,Pubmed,April 11, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,712,,
713,"Hazin, N Engl J Med, 2016",Hazin,"Hazin, A. N.; Poretti, A.; Cruz, D. D.; Tenorio, M.; van der Linden, A.; Pena, L. J.; Brito, C.; Gil, L. H.; Miranda-Filho, D. B.; Marques, E. T.; Martelli, C. M.; Alves, J. G.; Huisman, T. A.",Computed Tomographic Findings in Microcephaly Associated with Zika Virus,N Engl J Med,,,,2016,2010-present,April 7, 2016,27050112,10.1056/NEJMc1603617,2055,English,,"Instituto de Medicina Integral Professor Fernando Figueira, Recife, Brazil.; Johns Hopkins University School of Medicine, Baltimore, MD aporett1@jhmi.edu.; Research Center Aggeu Magalhaes, Recife, Brazil.; Oswaldo Cruz University Hospital, Recife, Brazil.; Johns Hopkins University School of Medicine, Baltimore, MD.",Brazil,Americas,United States,Not reported/unknown,,"To the Editor: Zika virus (ZIKV) is a mosquito-borne flavivirus that is transmitted primarily by Aedes aegypti mosquitoes.1 Starting in May 2015, an outbreak of ZIKV infection has been reported in Brazil in association with an increasing number of neonates with congenital microcephaly in ZIKV-affected regions.1 In these areas, the prevalence of congenital microcephaly increased by a factor of 20 over the prevalence before the outbreak.1 ZIKV RNA has been identified in the brain of a fetus with congenital microcephaly.2 In addition, ZIKV RNA was identified in the amniotic fluid of two women whose fetuses had congenital microcephaly detected on . . .",Pubmed,April 11, 2016,Yes,,Yes,,Scientific (journal) article,Yes,Original research,Yes,No,758,Clinical/epidemiological research,Case series
714,"Araujo, Arq Neuropsiquiatr, 2016",Araujo,"Araujo, L. M.; Ferreira, M. L.; Nascimento, O. J.",Guillain-Barre syndrome associated with the Zika virus outbreak in Brazil,Arq Neuropsiquiatr,74,3,253-5,2016,2010-present,April 7, 2016,27050856,10.1590/0004-282x20160035,2148,English,http://www.scielo.br/pdf/anp/v74n3/0004-282X-anp-74-03-0253.pdf,"Departamento de Medicina Interna Neurology, Universidade Federal Fluminense, Rio de Janeiro, RJ, Brazil.; Divisao de Neurologia, Hospital da Restauracao, Recife, PE, Brazil.",Brazil,Americas,Brazil,,,"Zika virus (ZIKV) is now considered an emerging flavivirosis, with a first large outbreak registered in the Yap Islands in 2007. In 2013, a new outbreak was reported in the French Polynesia, with associated cases of neurological complications including Guillain-Barre syndrome (GBS). The incidence of GBS has increased in Brazil since 2015, what is speculated to be secondary to the ZIKV infection outbreak. The gold-standard test for detection of acute ZIKV infection is the polymerase-chain reaction technique, an essay largely unavailable in Brazil. The diagnosis of GBS is feasible even in resource-limited areas using the criteria proposed by the GBS Classification Group, which is based solely on clinical grounds. Further understanding on the relationship of ZIKV with neurological complications is a research urgency.",Pubmed,April 11, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,714,,
715,"Nunes, J Pediatr (Rio J), 2016",Nunes,"Nunes, M. L.; Carlini, C. R.; Marinowic, D.; Neto, F. K.; Fiori, H. H.; Scotta, M. C.; Zanella, P. L.; Soder, R. B.; da Costa, J. C.",Microcephaly and Zika virus: a clinical and epidemiological analysis of the current outbreak in Brazil,J Pediatr (Rio J),,,,2016,2010-present,April 7, 2016,27049675,10.1016/j.jped.2016.02.009,2044,English,,"Faculdade de Medicina, Pontificia Universidade Catolica do Rio Grande do Sul do Sul (Inscer), Porto Alegre, RS, Brazil. Electronic address: nunes@pucrs.br.; Zika-Team, Instituto do Cerebro do Rio Grande do Sul (Inscer), Porto Alegre, RS, Brazil.; Zika-Team, Instituto do Cerebro do Rio Grande do Sul (Inscer), Porto Alegre, RS, Universidade Catolica do Rio Grande do Sul (PUCRS), Porto Alegre, RS, Brazil.; Faculdade de Medicina, Pontificia Universidade Catolica do Rio Grande do Sul do Sul (Inscer), Porto Alegre, RS, Brazil.; Zika-Team, Instituto do Cerebro do Rio Grande do Sul (Inscer), Porto Alegre, RS, Catolica do Rio Grande do Sul (PUCRS), Porto Alegre, RS, Brazil.",,,,,Cortical development; Desenvolvimento cortical; Gestacao; Microcefalia; Microcephaly; Neuroimagem; Neuroimaging; Pregnancy; Virus zika; Zika virus,"OBJECTIVE: This study aimed to critically review the literature available regarding the Zika virus (ZikaV) outbreak in Brazil and its possible association with microcephaly cases. SOURCES: Experts from Instituto do Cerebro do Rio Grande do Sul performed a critical (nonsystematic) literature review regarding different aspects of the ZikaV outbreak in Brazil, such as transmission, epidemiology, diagnostic criteria, and its possible association with the increase of February 2016 yielded 151 articles. The manuscripts were reviewed, as well as all publications/guidelines from the Brazilian Ministry of Health, World Health Organization and Centers for Disease Control and Prevention (CDC - United States). SUMMARY OF FINDINGS: Epidemiological data suggest a temporal association between the increased number of microcephaly notifications in Brazil and outbreak of ZikaV, primarily in the Brazil's Northeast. It has been previously documented that many different viruses might cause congenital acquired microcephaly. Still there is no consensus on the best curve to measure cephalic circumference, specifically in preterm neonates. Conflicting opinions regarding the diagnosis of microcephaly (below 2 or 3 standard deviations) that should be used for the notifications were also found in the literature. CONCLUSION: The development of diagnostic techniques that confirm a cause-effect association and studies regarding the physiopathology of the central nervous system impairment should be prioritized. It is also necessary to strictly define the criteria for the diagnosis of microcephaly to identify cases that should undergo an etiological investigation.",Pubmed,April 11, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Yes,Review,No,Yes,715,Clinical/epidemiological research,Epidemiological/clinical review
716,"Moreira, Clin Infect Dis, 2016",Moreira,"Moreira, J.; Lamas, C. C.; Siqueira, A.",Sexual transmission of Zika virus: implications for clinical care and public health policy,Clin Infect Dis,,,,2016,2010-present,April 7, 2016,27048746,10.1093/cid/ciw211,2103,English,http://cid.oxfordjournals.org/content/early/2016/04/05/cid.ciw211.full.pdf,"Instituto Nacional de Infectologia Evandro Chagas, Fundacao Oswaldo Cruz (FIOCRUZ), Rio de Janeiro, Brasil Instituto Nacional de Saude, Ministerio da Saude, Maputo, Mocambique.; Instituto Nacional de Infectologia Evandro Chagas, Fundacao Oswaldo Cruz (FIOCRUZ), Rio de Janeiro, Brasil.",,,,,,,Pubmed,April 11, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,716,,
717,"Focosi, Clin Infect Dis, 2016",Focosi,"Focosi, D.; Maggi, F.; Pistello, M.",Zika Virus: Implications for Public Health,Clin Infect Dis,,,,2016,2010-present,April 7, 2016,27048745,10.1093/cid/ciw210,2116,English,http://cid.oxfordjournals.org/content/early/2016/04/05/cid.ciw210.full.pdf,"North-Western Tuscany Blood Bank, Pisa University Hospital, Pisa, Italy d.focosi@ao-pisa.toscana.it.; Virology Unit, Pisa University Hospital, Pisa, Italy.; Virology Unit, Pisa University Hospital, Pisa, Italy Retrovirus Center and Virology Section, Department of Translational Research, University of Pisa, Pisa, Italy.",,,,,,"The World Health Organization has declared the current Zika virus (ZIKV) epidemic a public health emergency of international concern. Lack of vaccines and reliable diagnostic tests, broad geographical distribution of mosquito species that can transmit the virus, and absence of population immunity in newly affected countries are causes for concern. Although most infected persons are asymptomatic, ZIKV has been associated with a rise in cases of neurological complications and fetal central nervous system malformations. This defines such arbovirus as something whose transmission should be prevented. This review summarizes the current understanding of ZIKV biology and epidemiology, and possible interventions to prevent contagion and transmission.",Pubmed,April 11, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Yes,Review,No,Yes,717,Clinical/epidemiological research,Epidemiological/clinical review
718,"WHO, Zika situation report. Zika virus, Microcephaly and Guillain-Barré syndrome - 31 March 2016 and 07 April 2016, 2016",WHO,WHO,"Zika situation report. Zika virus, Microcephaly and Guillain-Barré syndrome - 31 March 2016 and 07 April 2016",,"Zika situation report. Zika virus, Microcephaly and Guillain-Barré syndrome - 31 March 2016 and 07 April 2016",,,2016,2010-present,April 7, 2016,,,2011,,http://www.who.int/emergencies/zika-virus/situation-report/7-april-2016/en/,,Switzerland,Europe,,Public/Government,,,WHO,April 11, 2016,Yes,,Yes,,Surveillance report or data,,,No,Yes,718,Clinical/epidemiological research,Case series
719,"Tambo, J Infect Public Health, 2016",Tambo,"Tambo, E.; Chuisseu, P. D.; Ngogang, J. Y.; Khater, E. I.",Deciphering emerging Zika and dengue viral epidemics: Implications for global maternal-child health burden,J Infect Public Health,,,,2016,2010-present,April 8, 2016,27052794,10.1016/j.jiph.2016.02.005,2087,English,http://ac.els-cdn.com/S1876034116300028/1-s2.0-S1876034116300028-main.pdf?_tid=b1bd177a-fff9-11e5-b641-00000aab0f6c&acdnat=1460388540_c6966df501d38c15eea9e7f288a5995d; http://ac.els-cdn.com/S1876034116300028/1-s2.0-S1876034116300028-main.pdf?_tid=a80eb4c8-fffd-11e5-a070-00000aacb362&acdnat=1460390241_b4e478bfe888fbd9ce43937e55eea362,"Biochemisry and Pharmaceutical Sciences Department, Higher Institute of Health Surveillance, Communication and Response (Africa DISCoR) Foundation, Yaounde, Cameroon. Electronic address: tambo0711@gmail.com.; Biochemisry and Pharmaceutical Sciences Department, Higher Institute of Health Sciences, Universite des Montagnes, Bangangte, Cameroon.; Biochemisry and Pharmaceutical Sciences Department, Higher Institute of Health Centre Hospitalier Universitaire (CHU), Yaounde, Cameroon.; Public Health Pests Laboratory, Jeddah Governate, Jeddah, Saudi Arabia.",,,,,Epidemics; Health; Maternal-child; Preparedness; Surveillance; Zika virus,"Since its discovery in 1947 in Uganda and control and eradication efforts have aimed at its vectors (Aedes mosquitoes) in Latin America in the 1950s, an absolute neglect of Zika programs and interventions has been documented in Aedes endemic and epidemic-prone countries. The current unprecedented Zika viral epidemics and rapid spread in the Western hemisphere pose a substantial global threat, with associated anxiety and consequences. The lack of safe and effective drugs and vaccines against Zika or dengue epidemics further buttresses the realization from the West Africa Ebola outbreak that most emerging disease-prone countries are still poorly prepared for an emergency response. This paper examines knowledge gaps in both emerging and neglected arthropod-borne flavivirus infectious diseases associated with poverty and their implications for fostering local, national and regional emerging disease preparedness, effective and robust surveillance-response systems, sustained control and eventual elimination. Strengthening the regional and Global Health Flavivirus Surveillance-Response Network (GHFV-SRN) with other models of socio-economic, climatic, environmental and ecological mitigation and adaptation strategies will be necessary to improve evidence-based national and global maternal-child health agenda and action plans.",Pubmed,April 11, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Yes,Review,No,Yes,719,Clinical/epidemiological research,Epidemiological/clinical review
720,"PAHO, Epidemiological update 8 April 2016, 2016",PAHO,PAHO,Epidemiological update 8 April 2016,,Epidemiological update 8 April 2016,,,2016,2010-present,April 8, 2016,,,2041,,http://www.paho.org/hq/index.php?option=com_docman&task=doc_view&Itemid=270&gid=34144&lang=en,,United States,Americas,,Public/Government,,,PAHO,April 11, 2016,Yes,,Yes,,Surveillance report or data,,,No,Yes,720,Clinical/epidemiological research,Ecological study/outbreak report
721,"Benelli, Parasitol Res, 2016",Benelli,"Benelli, G.; Lo Iacono, A.; Canale, A.; Mehlhorn, H.",Mosquito vectors and the spread of cancer: an overlooked connection?,Parasitol Res,,,,2016,2010-present,April 8, 2016,27053131,10.1007/s00436-016-5037-y,2146,English,http://download.springer.com/static/pdf/642/art%253A10.1007%252Fs00436-016-5037-y.pdf?originUrl=http%3A%2F%2Flink.springer.com%2Farticle%2F10.1007%2Fs00436-016-5037-y&token2=exp=1460389549~acl=%2Fstatic%2Fpdf%2F642%2Fart%25253A10.1007%25252Fs00436-016-5037-y.pdf%3ForiginUrl%3Dhttp%253A%252F%252Flink.springer.com%252Farticle%252F10.1007%252Fs00436-016-5037-y*~hmac=b2b1e6e8bd67e982af157309aff3432e36b9bca56393cae056905146cea2850c; http://download.springer.com/static/pdf/642/art%253A10.1007%252Fs00436-016-5037-y.pdf?originUrl=http%3A%2F%2Flink.springer.com%2Farticle%2F10.1007%2Fs00436-016-5037-y&token2=exp=1460391523~acl=%2Fstatic%2Fpdf%2F642%2Fart%25253A10.1007%25252Fs00436-016-5037-y.pdf%3ForiginUrl%3Dhttp%253A%252F%252Flink.springer.com%252Farticle%252F10.1007%252Fs00436-016-5037-y*~hmac=74377e4400c36101babc513f3b09550d4aa38a6ce3535f83a7b4053fdf18ebf7,"Insect Behaviour Group, Department of Agriculture, Food and Environment, University of Pisa, via del Borghetto 80, 56124, Pisa, Italy. g.benelli@sssup.it.; Sant'Anna School of Advanced Studies, Piazza Martiri della Liberta 33, 56127, Pisa, Italy.; Insect Behaviour Group, Department of Agriculture, Food and Environment, University of Pisa, via del Borghetto 80, 56124, Pisa, Italy.; Department of Parasitology, Heinrich Heine University, Dusseldorf, Germany.",,,,,Aedes; Anopheles; Arbovirus; Artesunate; Dengue; Epstein-Barr virus; Malaria; Nanosynthesis; Tumor biology; Zika virus,"Mosquitoes (Diptera: Culicidae) represent a key threat for millions of humans and animals worldwide, vectoring important pathogens and parasites, including malaria, dengue, filariasis, and Zika virus. Besides mosquito-borne diseases, cancers figure among the leading causes of mortality worldwide. It is expected that annual cancer cases will rise from 14 million in 2012 to 22 million within the next two decades. Notably, there are few contrasting evidences of the relationship between cancer and mosquito-borne diseases, with special reference to malaria. However, analogies at the cellular level for the two diseases were reported. Recently, a significant association of malaria incidence with all cancer mortality in 50 USA states was highlighted and may be explained by the ability of Plasmodium to induce suppression of the immune system. However, it was hypothesized that Anopheles vectors may transmit obscure viruses linked with cancer development. The possible activation of cancer pathways by mosquito feeding events is not rare. For instance, the hamster reticulum cell sarcoma can be transmitted through the bites of Aedes aegypti by a transfer of tumor cells. Furthermore, mosquito bites may influence human metabolic pathways following different mechanisms, leading to other viral infections and/or oncogenesis. Hypersensitivity to mosquito bites is routed by a unique pathogenic mechanism linking Epstein-Barr virus infection, allergy, and oncogenesis. During dengue virus infection, high viral titers, macrophage infiltration, and tumor necrosis factor alpha production in the local tissues are the three key important events that lead to hemorrhage. Overall, basic epidemiological knowledge on the relationships occurring between mosquito vector activity and the spread of cancer is urgently needed, as well as detailed information about the ability of Culicidae to transfer viruses or tumor cells among hosts over time. Current evidences on nanodrugs with multipotency against mosquito-borne diseases and cancers are reviewed, with peculiar attention to their mechanisms of action.",Pubmed,April 11, 2016,Yes,,No,Unrelated to Zika virus,Scientific (journal) article,Yes,Review,No,Yes,721,Basic and applied biomedical research,Basic research review
722,"Hoyt, Nat Biotechnol, 2016",Hoyt,"Hoyt, K.; Hatchett, R.",Preparing for the next Zika,Nat Biotechnol,34,4,384-6,2016,2010-present,April 8, 2016,27054989,10.1038/nbt.3532,2112,English,http://www.nature.com/nbt/journal/v34/n4/pdf/nbt.3532.pdf,"Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.; Biomedical Advanced Research and Development Authority (HHS/ASPR/BARDA), Washington, DC, USA.",,,,,,,Pubmed,April 11, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,722,,
723,"Citil-Dogan, J Matern Fetal Neonatal Med, 2016",Citil-Dogan,"Citil-Dogan, A.; Wayne, S.; Bauer, S.; Ogunyemi, D.; Kulkharni, S. K.; Maulik, D.; Carpenter, C. F.; Bahado-Singh, R. O.","THE ZIKA VIRUS AND PREGNANCY: EVIDENCE, MANAGEMENT, AND PREVENTION",J Matern Fetal Neonatal Med,,,Jan 41,2016,2010-present,April 8, 2016,27052666,10.3109/14767058.2016.1174210,2123,English,http://www.tandfonline.com/doi/pdf/10.3109/14767058.2016.1174210,"a Department of Obstetrics and Gynecology , William Beaumont Hospital , Royal Oak , MI.; b Grosse Pointe Shores , MI.; c Department of Obstetrics and Gynecology , Oakland University- William Beaumont School of Medicine , Royal Oak , MI.; d Department of Obstetrics and Gynecology, Faculty of Medicine , University of the West Indies , Kingston , Jamaica , West Indies.; e Department of Obstetrics and Gynecology , UMKC School of Medicine , Kansas City , Missouri.; f Department of Internal Medicine , Oakland University- William Beaumont School of Medicine , Royal Oak , MI.",,,,,Zika virus infection; pregnancy,"OBJECTIVE: To comprehensively review the available evidence and existing consensus reports and guidelines regarding the pregnancy and reproductive implications of the mosquito transmitted Zika virus infection. A primary focus was to provide pertinent information to aid clinicians in the management of pregnancies at risk for, exposed to or with confirmed Zika virus infection (ZIV). METHOD: An extensive literature review was performed using Pubmed. Practice guidelines, and consensus reports were accessed from international, national and professional organizations' websites. The clinical articles for ZIKV infection testing varied from case reports to small epidemiologic studies. RESULTS: A ZIKV epidemic has been declared in several countries in the Americas. Fifty-two travel associated ZIKV infection cases have been reported throughout the United States (as of February 10, 2016). The consequences of congenital fetal/newborn ZIKV infection could potentially have devastating consequences including miscarriage, fetal death, and major anomalies such as microcephaly, brain and brain-stem defects and long-term neurologic sequelae. While not definitive, current evidence suggest the existence of non-vector-borne transmission through sexual activity with an infected male partner. For women at risk for sexual transmission condom use is advised, especially during pregnancy. CONCLUSION: While ZIKV infection appears to be a mild disease in the general population the potential consequences to the fetus and newborn could be profound. Management guidelines are currently evolving and will be significantly impacted as new evidence develops. It is therefore imperative that obstetric health care providers keep abreast of this rapidly evolving information landscape that has so far characterized this outbreak.",Pubmed,April 11, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Yes,Review,No,Yes,723,Clinical/epidemiological research,Epidemiological/clinical review
724,"CDC Zika Response, MMWR Morb Mortal Wkly Rep, 2016",CDC Zika Response,CDC Zika Response,"Vital Signs: Preparing for Local Mosquito-Borne Transmission of Zika Virus - United States, 2016",MMWR Morb Mortal Wkly Rep,65,13,352,2016,2010-present,April 8, 2016,27054688,10.15585/mmwr.mm6513e1,2071,English,,,,,,,,Widespread Zika virus transmission in the Region of the Americas since 2015 has heightened the urgency of preparing for the possibility of expansion of mosquito-borne transmission of Zika virus during the 2016 mosquito season (1). CDC and other U.S. government agencies have been working with state and local government partners on prevention and early detection of Zika virus infection and will increase these activities during April as part of their preparation for the anticipated emergence of mosquito-borne transmission of Zika virus in the continental United States.,Pubmed,April 11, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",News item or lay press,,,No,Yes,724,,
725,"Chen, J Chin Med Assoc, 2016",Chen,"Chen, H. L.; Tang, R. B.",Why Zika virus infection has become a public health concern?,J Chin Med Assoc,79,4,174-8,2016,2010-present,April 8, 2016,27052792,10.1016/j.jcma.2016.03.001,2124,English,http://ac.els-cdn.com/S1726490116300065/1-s2.0-S1726490116300065-main.pdf?_tid=af576792-fff9-11e5-a7bb-00000aacb35d&acdnat=1460388535_336a787a7a589766afc0af82d40e6dcb; http://ac.els-cdn.com/S1726490116300065/1-s2.0-S1726490116300065-main.pdf?_tid=15c44a00-fffe-11e5-ba56-00000aab0f6c&acdnat=1460390425_6a0bdd99d75b57603134d25e2607360c,"Department of Pediatrics, Keelung Hospital, Ministry of Health and Welfare, Keelung, Taiwan, ROC.; Division of Pediatrics, Cheng Hsin General Hospital, Taipei, Taiwan, ROC. Electronic address: ch9406@chgh.org.com.tw.",,,,,Zika virus; microcephaly; transmission,"Prior to 2015, Zika Virus (ZIKV) outbreaks had occurred in areas of Africa, Southeast Asia, and the Pacific Islands. Although a causal relationship between Zika infection during pregnancy and microcephaly is strongly suspected, such a connection has not yet been scientifically proven. In May 2015, the outbreak of ZIKV infection in Brazil led to reports of syndrome and pregnant women giving Health Organization (PAHO) issued an alert regarding the first confirmed ZIKV infection in Brazil. Currently, ZIKV outbreaks are ongoing and it will be difficult to predict how the virus will spread over time. ZIKV is transmitted to humans primarily through the bite of infected mosquitos, Aedes aegypti and Aedes albopictus. These mosquitoes are the principle vectors of dengue, and ZIKV disease generally is reported to include symptoms associated with acute febrile illnesses that clinically resembles dengue fever. The laboratory diagnosis can be performed by using reverse-transcriptase polymerase chain reaction (RT-PCR) on serum, viral nucleic acid and virus-specific immunoglobulin M. There is currently no vaccine and antiviral treatment available for ZIKV infection, and the only way to prevent congenital ZIKV infection is to prevent maternal infection. In February 2016, the Taiwan Centers for Disease Control (Taiwan CDC) activated ZIKV as a Category V Notifiable Infectious Disease similar to Ebola virus disease and MERS.",Pubmed,April 11, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Yes,Review,No,Yes,725,Clinical/epidemiological research,Epidemiological/clinical review
726,"Flores, Cleve Clin J Med, 2016",Flores,"Flores, M. S.; Burgess, T. H.; Rajnik, M.",Zika virus: A primer for clinicians,Cleve Clin J Med,83,4,261-70,2016,2010-present,April 8, 2016,27055200,10.3949/ccjm.83a.16027,2059,English,,"Department of Pediatrics, Uniformed Services University, Bethesda, MD, USA.; Department of Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.; Infectious Diseases Clinical Research Program, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.; Department of Pediatrics, F. Edward Hebert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. E-mail: michael.rajnik@usuhs.edu.",,,,,,"The ongoing outbreak of Zika virus infection that began in South America and Central America in 2014 is worrisome because of associations with fetal microcephaly and with Guillain-Barre syndrome. Here we summarize what has happened and what is known so far. As the outbreak continues to evolve, we urge clinicians to watch for updates at cdc.gov.",Pubmed,April 11, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Yes,Review,No,Yes,726,Clinical/epidemiological research,Epidemiological/clinical review
727,"Mandell, Cleve Clin J Med, 2016",Mandell,"Mandell, B. F.",Zika--a new continent and new complications?,Cleve Clin J Med,83,4,247-8,2016,2010-present,April 8, 2016,27055196,10.3949/ccjm.83b.04016,2051,English,http://www.obgmanagement.com/home/article/zika-a-new-continent-and-new-complications/bf3e048c03f0f801c5d381b144289ab2.html,,,,,,,,Pubmed,April 11, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,727,,
728,"Jouannic, Gynecol Obstet Fertil, 2016",Jouannic,"Jouannic, J. M.; Huissoud, C.",[Zika virus and pregnancy],Gynecol Obstet Fertil,,,,2016,2010-present,April 8, 2016,27053037,10.1016/j.gyobfe.2016.03.006,2111,French,http://ac.els-cdn.com/S1297958916300583/1-s2.0-S1297958916300583-main.pdf?_tid=acd78772-fff9-11e5-83d5-00000aacb362&acdnat=1460388531_f9da5af6888962b9e3f522f027988454; http://ac.els-cdn.com/S1297958916300583/1-s2.0-S1297958916300583-main.pdf?_tid=e591d06e-fffd-11e5-b7a2-00000aacb35e&acdnat=1460390344_826cb135a80c96996cc29fbbab497471,"Service de medecine foetale, hopital Trousseau, AP-HP, Paris 6, Federation francaise des centres pluridisciplinaires de diagnostic prenatal, 26, avenue du Dr-Arnold-Netter, 75012 Paris, France. Electronic address: jean-marie.jouannic@aphp.fr.; Service de gynecologie-obstetrique, maternite de la Croix-Rousse, HCL, 103, grande rue de la Croix-Rousse, 69004 Lyon, France.",,,,,Brain anomalies; Fetal infection; Infection materno-foetale; Malformation cerebrale; Prenatal; Ultrasound; Virus Zika; Zika virus; Echographie,,Pubmed,April 11, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,728,,
729,"Baud, Lancet Infect Dis, 2016",Baud,"Baud, D. Biology; Medicine, University of Lausanne; University Hospital, Lausanne Switzerland Electronic address david baud chuv ch; Van Mieghem, T.; Musso, D.; Truttmann Ac Lausanne, Switzerland; Panchaud, A.; Vouga, M. Biology; Medicine, University of Lausanne; University Hospital, Lausanne Switzerland",Clinical management of pregnant women exposed to Zika virus,Lancet Infect Dis,,,,2016,2010-present,April 9, 2016,27056096,10.1016/s1473-3099(16)30008-1,2147,English,http://ac.els-cdn.com/S1473309916300081/1-s2.0-S1473309916300081-main.pdf?_tid=a1596e88-fff9-11e5-8195-00000aab0f26&acdnat=1460388512_90b79609caa9e537dd48967e365a6469; http://ac.els-cdn.com/S1473309916300081/1-s2.0-S1473309916300081-main.pdf?_tid=47ee2dc0-fffe-11e5-a9db-00000aacb35f&acdnat=1460390509_afd26f10e26f1ad75a21bc5e406373df,"Department of Obstetrics and Gynecology, Division of Woman and Child, University Hospitals Leuven, Leuven, Belgium.; Unit of Emerging Infectious Diseases, Institut Louis Malarde, Tahiti, French Polynesia.; School of Pharmaceutical Sciences, University of Geneva and University of Department of Epidemiology, Harvard T H Chan School of Public Health, Boston, MA, USA.",,,,,,,Pubmed,April 11, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,729,,
730,"Doshi, BMJ, 2016",Doshi,"Doshi, P.",Convicting Zika,BMJ,353,,i1847,2016,2010-present,April 9, 2016,27056643,10.1136/bmj.i1847,2120,English,http://www.bmj.com/content/bmj/353/bmj.i1847.full.pdf,,,,,,,,Pubmed,April 11, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,730,,
731,"Watrin, Medicine (Baltimore), 2016",Watrin,"Watrin, L.; Ghawche, F.; Larre, P.; Neau, J. P.; Mathis, S.; Fournier, E.",Guillain-Barre Syndrome (42 Cases) Occurring During a Zika Virus Outbreak in French Polynesia,Medicine (Baltimore),95,14,e3257,2016,2010-present,April 9, 2016,27057874,10.1097/md.0000000000003257,2013,English,http://ovidsp.tx.ovid.com/sp-3.19.0a/ovidweb.cgi?QS2=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,"From the Department of Neurology (LW, J-PN, SM), Poitiers University Hospital Neurophysiology (EF), La Pitie-Salpetriere University Hospital Center, AP-HP, Groupe Hospitalier Pitie-Salpetriere, Bd de l'Hopital, Paris cedex, France.",France,Europe,France,No funding received,,"Zika virus (transmitted by mosquitoes) reached French Polynesia for the first time in 2013, leading to an epidemic affecting 10% of the total population. So far, it has not been known to induce any neurological complications, but, a few weeks after the outbreak, an unexpectedly high number of 42 patients presented with Guillain-Barre syndrome.We report the clinical and electrophysiological characteristics of this series. Males predominated with a sex ratio of 2.82 (mean age: 46). All patients (except 2) were native Polynesian. At admission, 55% were able to walk unaided against 38% at nadir, 24% had swallowing troubles (nadir: 45%), 74% had motor weakness of the limbs (nadir: 86%) and deep tendon reflexes were diminished or not found in the vast majority of patients. Mean duration of the progressive phase and of the plateau phase was respectively 7 and 9 days. Thirty-eight percent of the patients were admitted in intensive care unit and 10 patients underwent tracheotomy. Nerve electrophysiological studies at admission showed marked distal motor conduction alterations, which had almost completely axonal neuropathy (AMAN) than of acute inflammatory demyelinating polyneuropathy (AIDP). Lumbar puncture showed elevated proteins in 90% of the cases, with cell count always inferior to 50/muL.This epidemic raises several questions, such as the potential existence of interactions between Zika virus and Polynesian HLA system and/or the consequences of several recombination events of this virus. This situation should call for increased vigilance, especially in countries where Aedes mosquitoes are present.",Pubmed,April 11, 2016,Yes,,Yes,,Scientific (journal) article,Yes,Original research,Yes,No,430,Clinical/epidemiological research,Case series
732,"Hotez, PLoS Negl Trop Dis, 2016",Hotez,"Hotez, P. J.","Neglected Tropical Diseases in the Anthropocene: The Cases of Zika, Ebola, and Other Infections",PLoS Negl Trop Dis,10,4,e0004648,2016,2010-present,April 9, 2016,27058728,10.1371/journal.pntd.0004648,2113,English,http://journals.plos.org/plosntds/article/asset?id=10.1371/journal.pntd.0004648.PDF,"Departments of Pediatrics and Molecular Virology and Microbiology, National School of Tropical Medicine, Baylor College of Medicine, Houston, Texas, United States of America.; Sabin Vaccine Institute and Texas Children's Hospital Center for Vaccine Development, Houston, Texas, United States of America.; James A. Baker III Institute for Public Policy, Rice University, Houston, Texas, United States of America.; Department of Biology, Baylor University, Waco, Texas, United States of America.",,,,,,,Pubmed,April 11, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,732,,
733,"Drosten, Eurosurveillance, 2016",Drosten,"Drosten, C.",Zika virus and congenital malformations in perspective,Eurosurveillance,21,13,,2016,2010-present,April 9, 2016,27055385,10.2807/1560-7917.es.2016.21.13.30182,2062,English,,"Institute of Virology, University of Bonn, Germany.",,,,,Zika virus; emerging or re-emerging diseases; vector-borne infections; viral infections,,Pubmed,April 11, 2016,No,Duplicate of existing record,,,,,,,,,,
734,"Bricaire, Presse Med, 2016",Bricaire,"Bricaire, F.",[Zika virus: a new epidemic?],Presse Med,45,3,281-3,2016,2010-present,April 9, 2016,27055374,10.1016/j.lpm.2016.03.001,2144,French,http://ac.els-cdn.com/S0755498216300057/1-s2.0-S0755498216300057-main.pdf?_tid=a836d92a-fff9-11e5-85bb-00000aacb35f&acdnat=1460388524_66019dac080bb511d806a77c6f703859; http://ac.els-cdn.com/S0755498216300057/1-s2.0-S0755498216300057-main.pdf?_tid=41e17cde-fffe-11e5-b548-00000aab0f01&acdnat=1460390499_94f345cc0d94a0d53be01705b9dcfb7c,"Groupe hospitalier Pitie-Salpetriere, service des maladies infectieuses et tropicales, 43-87, boulevard de l'Hopital, 75013 Paris, France. Electronic address: francois.bricaire@psl.aphp.fr.",,,,,,,Pubmed,April 11, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,734,,
735,"InVS, Point Epidemiologique CIRE Antilles Guyane, 2016",InVS,InVS,Point épidémio: Emergence du virus zika aux Antilles Guyane : Situation épidémiologique - 07 avril 2016,Point Epidemiologique CIRE Antilles Guyane,13,,,2016,2010-present,April 13, 2016,,,2033,French,http://www.invs.sante.fr/fr/Publications-et-outils/Points-epidemiologiques/Tous-les-numeros/Antilles-Guyane/2016/Situation-epidemiologique-du-virus-Zika-aux-Antilles-Guyane.-Point-au-7-avril-2016,,France,Europe,,Public/Government,,,Institute de veille sanitaire,April 11, 2016,Yes,,No,"Zika, indirect evidence or other topic",Surveillance report or data,,,No,Yes,735,Clinical/epidemiological research,Ecological study/outbreak report
736,"Martinez-Pulgarin, Travel Med Infect Dis, 2016",Martinez-Pulgarin,"Martinez-Pulgarin, D. F.; Acevedo-Mendoza, W. F.; Cardona-Ospina, J. A.; Rodriguez-Morales, A. J.; Paniz-Mondolfi, A. E.",A bibliometric analysis of global Zika research,Travel Med Infect Dis,14,1,55-57,2016,2010-present,,,,2107,,http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emed13&AN=2015313656; http://lshtmsfx.hosted.exlibrisgroup.com/lshtm?sid=OVID:embase&id=pmid:&id=doi:10.1016%2Fj.tmaid.2015.07.005&issn=1477-8939&isbn=&volume=14&issue=1&spage=55&pages=55-57&date=2016&title=Travel+Medicine+and+Infectious+Disease&atitle=A+bibliometric+analysis+of+global+Zika+research&aulast=Martinez-Pulgarin&pid=%3Cauthor%3EMartinez-Pulgarin+D.F.%3BAcevedo-Mendoza+W.F.%3BCardona-Ospina+J.A.%3BRodriguez-Morales+A.J.%3BPaniz-Mondolfi+A.E.%3C%2Fauthor%3E%3CAN%3E2015313656%3C%2FAN%3E%3CDT%3EJournal%3A+Letter%3C%2FDT%3E; http://ac.els-cdn.com/S1477893915001209/1-s2.0-S1477893915001209-main.pdf?_tid=372ca55e-ffc5-11e5-a9c1-00000aacb362&acdnat=1460366000_b295e118d3582f788ea51bf5154f5bce; http://ac.els-cdn.com/S1477893915001209/1-s2.0-S1477893915001209-main.pdf?_tid=db96d9b0-fffd-11e5-9638-00000aab0f26&acdnat=1460390328_e84538386c4c983d074f9d3d349ea506,,,,,,,,Embase,April 11, 2016,No,Duplicate of existing record,,,,,,,,,,
737,"Wilson, Travel Med Infect Dis, 2016",Wilson,"Wilson, M. E.; Schlagenhauf, P.","Aedes and the triple threat of DENV, CHIKV, ZIKV - Arboviral risks and prevention at the 2016 Rio Olympic games",Travel Med Infect Dis,14,1,01. Apr,2016,2010-present,,,,2081,,http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emed13&AN=20160119822; http://lshtmsfx.hosted.exlibrisgroup.com/lshtm?sid=OVID:embase&id=pmid:&id=doi:10.1016%2Fj.tmaid.2016.01.010&issn=1477-8939&isbn=&volume=14&issue=1&spage=1&pages=1-4&date=2016&title=Travel+Medicine+and+Infectious+Disease&atitle=Aedes+and+the+triple+threat+of+DENV%2C+CHIKV%2C+ZIKV+-+Arboviral+risks+and+prevention+at+the+2016+Rio+Olympic+games&aulast=Wilson&pid=%3Cauthor%3EWilson+M.E.%3BSchlagenhauf+P.%3C%2Fauthor%3E%3CAN%3E20160119822%3C%2FAN%3E%3CDT%3EJournal%3A+Review%3C%2FDT%3E; http://ac.els-cdn.com/S1477893916000120/1-s2.0-S1477893916000120-main.pdf?_tid=39b6d3c6-ffc5-11e5-a831-00000aacb361&acdnat=1460366004_0f627ecfd01880070dfa1aa3fc9e97bb; http://ac.els-cdn.com/S1477893916000120/1-s2.0-S1477893916000120-main.pdf?_tid=923f7dd0-fffd-11e5-8878-00000aacb35f&acdnat=1460390205_985b75ade84dd63ed34e60e5b4c1f12d,,,,,,,,Embase,April 11, 2016,No,Duplicate of existing record,,,,,,,,,,
738,"Venturi, Eurosurveillance, 2016",Venturi,"Venturi, G.; Zammarchi, L.; Fortuna, C.; Remoli, M. E.; Benedetti, E.; Fiorentini, C.; Trotta, M.; Rizzo, C.; Mantella, A.; Rezza, G.; Bartoloni, A.",Authors' reply: Diagnostic challenges to be considered regarding zika virus in the context of the presence of the vector aedes albopictus in Europe,Eurosurveillance,21,10,,2016,2010-present,,,,2015,,http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emed13&AN=20160222778; http://lshtmsfx.hosted.exlibrisgroup.com/lshtm?sid=OVID:embase&id=pmid:&id=doi:10.2807%2F1560-7917.ES.2016.21.10.30163&issn=1025-496X&isbn=&volume=21&issue=10&spage=no+pagination&pages=no+pagination&date=2016&title=Eurosurveillance&atitle=Authors%27+reply%3A+Diagnostic+challenges+to+be+considered+regarding+zika+virus+in+the+context+of+the+presence+of+the+vector+aedes+albopictus+in+Europe&aulast=Venturi&pid=%3Cauthor%3EVenturi+G.%3BZammarchi+L.%3BFortuna+C.%3BRemoli+M.E.%3BBenedetti+E.%3BFiorentini+C.%3BTrotta+M.%3BRizzo+C.%3BMantella+A.%3BRezza+G.%3BBartoloni+A.%3C%2Fauthor%3E%3CAN%3E20160222778%3C%2FAN%3E%3CDT%3EJournal%3A+Letter%3C%2FDT%3E,,,,,,,,Embase,April 11, 2016,No,Duplicate of existing record,,,,,,,,,,
739,"Carneiro, Microbes Infect, 2016",Carneiro,"Carneiro, L. A. M.; Travassos, L. H.",Autophagy and viral diseases transmitted by Aedes aegypti and Aedes albopictus,Microbes Infect,18,3,169-171,2016,2010-present,,,,2140,,http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emed13&AN=20160100622; http://lshtmsfx.hosted.exlibrisgroup.com/lshtm?sid=OVID:embase&id=pmid:&id=doi:10.1016%2Fj.micinf.2015.12.006&issn=1286-4579&isbn=&volume=18&issue=3&spage=169&pages=169-171&date=2016&title=Microbes+and+Infection&atitle=Autophagy+and+viral+diseases+transmitted+by+Aedes+aegypti+and+Aedes+albopictus&aulast=Carneiro&pid=%3Cauthor%3ECarneiro+L.A.M.%3BTravassos+L.H.%3C%2Fauthor%3E%3CAN%3E20160100622%3C%2FAN%3E%3CDT%3EJournal%3A+Editorial%3C%2FDT%3E; http://ac.els-cdn.com/S1286457916000046/1-s2.0-S1286457916000046-main.pdf?_tid=18f47ef4-ffc5-11e5-8870-00000aab0f27&acdnat=1460365949_29a4ce1053b5704714e5c67569e6301a; http://ac.els-cdn.com/S1286457916000046/1-s2.0-S1286457916000046-main.pdf?_tid=1f61ea86-fffe-11e5-aefb-00000aab0f6c&acdnat=1460390441_487cc5120885e15f965e14620079f5eb,,,,,,,,Embase,April 11, 2016,No,Duplicate of existing record,,,,,,,,,,
740,"Cerbino-Neto, Emerg Infect Dis, 2016",Cerbino-Neto,"Cerbino-Neto, Jos","Clinical Manifestations of Zika Virus Infection, Rio de Janeiro, Brazil, 2015",Emerg Infect Dis,22,6 http://wwwnc.cdc.gov/eid/article/22/6/16-0375_article.htm,,2016,2010-present,,,,2064,,,,,,,,,,EID,April 11, 2016,Yes,,No,"Zika, not relevant to causality framework",Scientific (journal) article,Yes,Original research,No,Yes,740,Clinical/epidemiological research,Cross-sectional study
741,"Piorkowski, New Microbes New Infect, 2016",Piorkowski,"Piorkowski, G.; Richard, P.; Baronti, C.; Gallian, P.; Charrel, R.; Leparc-Goffart, I.; de Lamballerie, X.",Complete coding sequence of Zika virus from Martinique outbreak in 2015,New Microbes New Infect,11,,52-53,2016,2010-present,,,,2038,,http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emed13&AN=20160241446; http://lshtmsfx.hosted.exlibrisgroup.com/lshtm?sid=OVID:embase&id=pmid:&id=doi:10.1016%2Fj.nmni.2016.02.013&issn=2052-2975&isbn=&volume=11&issue=&spage=52&pages=52-53&date=2016&title=New+Microbes+and+New+Infections&atitle=Complete+coding+sequence+of+Zika+virus+from+Martinique+outbreak+in+2015&aulast=Piorkowski&pid=%3Cauthor%3EPiorkowski+G.%3BRichard+P.%3BBaronti+C.%3BGallian+P.%3BCharrel+R.%3BLeparc-Goffart+I.%3Bde+Lamballerie+X.%3C%2Fauthor%3E%3CAN%3E20160241446%3C%2FAN%3E%3CDT%3EJournal%3A+Article%3C%2FDT%3E,,,,,,,,Embase,April 11, 2016,Yes,,No,"Zika, indirect evidence or other topic",Scientific (journal) article,Yes,Original research,No,Yes,741,Basic and applied biomedical research,Sequence analysis and phylogenetics
742,"Ulibarri, , 2016",Ulibarri,"Ulibarri, G; Betanzos, A; Betanzos, M; Rojas, JJ","Control of Aedes aegypti in a remote Guatemalan community vulnerable to dengue, chikungunya and Zika virus: Prospective evaluation of an integrated intervention of web-based health worker training in vector control, low-cost ecological ovillantas, and community engagement [version 1; referees: awaiting peer review]",,5,598,,2016,2010-present,,,10.12688/f1000research.8461.1,2017,,http://f1000r.es/713,,,,,,,"Objective: To study the effectiveness of an integrated intervention of health worker training, a low-cost ecological mosquito ovitrap, and community engagement on Aedes spp. mosquito control over 10 months in 2015 in an urban remote community in Guatemala at risk of dengue, chikungunya and Zika virus transmission.     Methods: We implemented a three-component integrated intervention consisting of: web-based training of local health personnel in vector control, cluster-randomized assignment of ecological ovillantas or standard ovitraps to capture Aedes aegypti mosquito eggs, and community engagement to promote participation of community members and health personnel in the understanding and maintenance of ovitraps for mosquito control. The intervention was implemented in local collaboration with the Ministry of Health's Vector Control Programme, and in international collaboration with the National Institute of Public Health in Mexico.     Findings: Eighty percent of the 25 local health personnel enrolled in the training programme received accreditation of their improved knowledge of vector control. Significantly more eggs were trapped by  ecological ovillantas than standard ovitraps over the 10 month (42 week) study period (t=5.2577; p<0.05). Among both community members and health workers, the levels of knowledge, interest, and participation in community mosquito control and trapping increased. Recommendations for enhancing and sustaining community mosquito control were identified.     Conclusion: Our three-component integrated intervention proved beneficial to this remote community at risk of mosquito-borne diseases such as dengue, chikungunya, and Zika. The combination of training of health workers, low-cost ecological ovillanta to destroy the second generation of mosquitoes, and community engagement ensured the project met local needs and fostered collaboration and participation of the community, which can help improve sustainability. The ovillanta intervention and methodology may be modified to target other species such as Culex, should it be established that such mosquitoes carry Zika virus in addition to Aedes.",F1000,April 11, 2016,Yes,,No,"Zika, not relevant to causality framework",Scientific (journal) article,No,Original research,No,Yes,742,Environmental and vector research,Vector control studies
743,"Gautret, Travel Med Infect Dis, 2016",Gautret,"Gautret, P.; Simon, F.","Dengue, chikungunya and Zika and mass gatherings: What happened in Brazil, 2014",Travel Med Infect Dis,14,1,07. Aug,2016,2010-present,,,,2115,,http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emed13&AN=20160015733; http://lshtmsfx.hosted.exlibrisgroup.com/lshtm?sid=OVID:embase&id=pmid:&id=doi:10.1016%2Fj.tmaid.2015.12.004&issn=1477-8939&isbn=&volume=14&issue=1&spage=7&pages=7-8&date=2016&title=Travel+Medicine+and+Infectious+Disease&atitle=Dengue%2C+chikungunya+and+Zika+and+mass+gatherings%3A+What+happened+in+Brazil%2C+2014&aulast=Gautret&pid=%3Cauthor%3EGautret+P.%3BSimon+F.%3C%2Fauthor%3E%3CAN%3E20160015733%3C%2FAN%3E%3CDT%3EJournal%3A+Editorial%3C%2FDT%3E; http://ac.els-cdn.com/S1477893915002057/1-s2.0-S1477893915002057-main.pdf?_tid=3c50ae7c-ffc5-11e5-98a2-00000aacb35f&acdnat=1460366009_dcf688824ff742967fb220bdbd53eaa5; http://ac.els-cdn.com/S1477893915002057/1-s2.0-S1477893915002057-main.pdf?_tid=f4afd99c-fffd-11e5-b497-00000aab0f01&acdnat=1460390370_d64477fdb4d26af223a4bd05cd758d47,,,,,,,,Embase,April 11, 2016,No,Duplicate of existing record,,,,,,,,,,
744,"Salvador, Travel Med Infect Dis, 2016",Salvador,"Salvador, F. S.; Fujita, D. M.",Entry routes for Zika virus in Brazil after 2014 world cup: New possibilities,Travel Med Infect Dis,14,1,49-51,2016,2010-present,,,,2093,,http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emed13&AN=20151008185; http://lshtmsfx.hosted.exlibrisgroup.com/lshtm?sid=OVID:embase&id=pmid:&id=doi:10.1016%2Fj.tmaid.2015.10.004&issn=1477-8939&isbn=&volume=14&issue=1&spage=49&pages=49-51&date=2016&title=Travel+Medicine+and+Infectious+Disease&atitle=Entry+routes+for+Zika+virus+in+Brazil+after+2014+world+cup%3A+New+possibilities&aulast=Salvador&pid=%3Cauthor%3ESalvador+F.S.%3BFujita+D.M.%3C%2Fauthor%3E%3CAN%3E20151008185%3C%2FAN%3E%3CDT%3EJournal%3A+Letter%3C%2FDT%3E; http://ac.els-cdn.com/S1477893915001738/1-s2.0-S1477893915001738-main.pdf?_tid=42c03bec-ffc5-11e5-aead-00000aab0f6c&acdnat=1460366019_4df084adccc96ca5691e5141da93bb4d; http://ac.els-cdn.com/S1477893915001738/1-s2.0-S1477893915001738-main.pdf?_tid=be8fa7f2-fffd-11e5-a11a-00000aab0f6b&acdnat=1460390279_efae6e7ab2345b6877f6bf4de04d2940,,,,,,,,Embase,April 11, 2016,No,Duplicate of existing record,,,,,,,,,,
745,"PAHO, Epidemiological update 31 March 2016, 2016",PAHO,PAHO,Epidemiological update 31 March 2016,,Epidemiological update 31 March 2016,,,2016,2010-present,,,,2042,,http://www.paho.org/hq/index.php?option=com_docman&task=doc_view&Itemid=270&gid=34041&lang=en,,United States,Americas,,Public/Government,,,PAHO,April 11, 2016,Yes,,Yes,,Surveillance report or data,,,No,Yes,745,Clinical/epidemiological research,Case report
746,"Coelho, Lancet Infect Dis, 2016",Coelho,"Coelho, Fl",Epidemiological data accessibility in Brazil,Lancet Infect Dis,,,,2016,2010-present,,,http://dx.doi.org/10.1016/S1473-3099(16)30007-X,2122,English,http://www.thelancet.com/journals/laninf/article/PIIS1473-3099%2816%2930007-X/fulltext; http://ac.els-cdn.com/S147330991630007X/1-s2.0-S147330991630007X-main.pdf?_tid=0e686d18-fffe-11e5-a27b-00000aab0f6b&acdnat=1460390413_8260a423a56d9f6527f59ad0d8be4ede,,,,,,,,Lancet,April 11, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,746,,
747,"Tepper, MMWR Morb Mortal Wkly Rep, 2016",Tepper,"Tepper, Naomi K.; Goldberg, Howard I.; Bernal, Manuel I. Vargas; Rivera, Brenda; Frey, Meghan T.; Malave, Claritsa; Renquist, Christina M.; Bracero, Nabal Jose; Dominguez, Kenneth L.; Sanchez, Ramon E.; Shapiro-Mendoza, Carrie K.; Rodriguez, Blanca R. Cuevas; Simeone, Regina M.; Pesik, Nicki T.; Barfield, Wanda D.; Ko, Jean Y.; Galang, Romeo R.; Perez-Padilla, Janice; Polen, Kara N. D.; Honein, Margaret A.; Rasmussen, Sonja A.; Jamieson, Denise J.",Estimating Contraceptive Needs and Increasing Access to Contraception in Response to the Zika Virus Disease Outbreak ,MMWR Morb Mortal Wkly Rep,65,12,311-314 %U http://www.cdc.gov/mmwr/volumes/65/wr/mm6512e1.htm,2016,2010-present,,,,2019,,,,,,,,,,CDC,April 11, 2016,No,Duplicate of existing record,,,,,,,,,,
748,"Port, bioRxiv, 2016",Port,"Port, Fillip; Bullock, Simon L",Expansion of the CRISPR toolbox in an animal with tRNA-flanked Cas9 and Cpf1 gRNAs,bioRxiv,,,,2016,2010-present,,,10.1101/046417,2098,,http://biorxiv.org/content/biorxiv/early/2016/03/31/046417.1.full.pdf,,,,,,,"We present vectors for producing multiple CRISPR gRNAs from a single RNA polymerase II or III transcript in Drosophila. The system, which is based on liberation of gRNAs by processing of flanking tRNAs, permits highly efficient multiplexing of Cas9-based mutagenesis. We also demonstrate that the tRNA-gRNA system markedly increases the efficacy of conditional gene disruption by Cas9 and can promote editing by the recently discovered RNA-guided endonuclease Cpf1.",BiorXiv,April 11, 2016,Yes,,No,Unrelated to Zika virus,Scientific (journal) article,No,Original research,No,Yes,748,Basic and applied biomedical research,Other basic research
749,"Reyna-Villasmil, Medicina Clinica, 2016",Reyna-Villasmil,"Reyna-Villasmil, E.; Lopez-Sanchez, G.; Santos-Bolivar, J.",Guillain-Barre syndrome due to Zika virus during pregnancy. [Spanish],Medicina Clinica,146,7,331-332,2016,2010-present,,,,2096,,http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emed13&AN=20160174210; http://lshtmsfx.hosted.exlibrisgroup.com/lshtm?sid=OVID:embase&id=pmid:&id=doi:10.1016%2Fj.medcli.2016.02.002&issn=0025-7753&isbn=&volume=146&issue=7&spage=331&pages=331-332&date=2016&title=Medicina+Clinica&atitle=Sindrome+de+Guillain-Barre+debido+al+virus+del+Zika+durante+el+embarazo&aulast=Reyna-Villasmil&pid=%3Cauthor%3EReyna-Villasmil+E.%3BLopez-Sanchez+G.%3BSantos-Bolivar+J.%3C%2Fauthor%3E%3CAN%3E20160174210%3C%2FAN%3E%3CDT%3EJournal%3A+Letter%3C%2FDT%3E; http://ac.els-cdn.com/S002577531600083X/1-s2.0-S002577531600083X-main.pdf?_tid=27227d14-ffc5-11e5-a1b3-00000aacb35e&acdnat=1460365973_84f5b522ff71c3fd320bb8584b773442; http://ac.els-cdn.com/S002577531600083X/1-s2.0-S002577531600083X-main.pdf?_tid=ca4680ac-fffd-11e5-8196-00000aab0f26&acdnat=1460390299_98739a71cb6740d54dd11013df1f5f1c,,,,,,,,Embase,April 11, 2016,No,Duplicate of existing record,,,,,,,,,,
750,"Sabogal-Roman, Travel Med Infect Dis, 2016",Sabogal-Roman,"Sabogal-Roman, J. A.; Murillo-Garcia, D. R.; Camila Yepes-Echeverri, M.; Restrepo-Mejia, J. D.; Granados-Alvarez, S.; Paniz-Mondolfi, A. E.; Villamil-Gomez, W. E.; Zapata-Cerpa, D. C.; Barreto-Rodriguez, K.; Rodriguez-Morales, A. J.","Healthcare students and workers' knowledge about transmission, epidemiology and symptoms of Zika fever in four cities of Colombia",Travel Med Infect Dis,14,1,52-54,2016,2010-present,,,,2094,,http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emed13&AN=20160004639; http://lshtmsfx.hosted.exlibrisgroup.com/lshtm?sid=OVID:embase&id=pmid:&id=doi:10.1016%2Fj.tmaid.2015.12.003&issn=1477-8939&isbn=&volume=14&issue=1&spage=52&pages=52-54&date=2016&title=Travel+Medicine+and+Infectious+Disease&atitle=Healthcare+students+and+workers%27+knowledge+about+transmission%2C+epidemiology+and+symptoms+of+Zika+fever+in+four+cities+of+Colombia&aulast=Sabogal-Roman&pid=%3Cauthor%3ESabogal-Roman+J.A.%3BMurillo-Garcia+D.R.%3BCamila+Yepes-Echeverri+M.%3BRestrepo-Mejia+J.D.%3BGranados-Alvarez+S.%3BPaniz-Mondolfi+A.E.%3BVillamil-Gomez+W.E.%3BZapata-Cerpa+D.C.%3BBarreto-Rodriguez+K.%3BRodriguez-Morales+A.J.%3C%2Fauthor%3E%3CAN%3E20160004639%3C%2FAN%3E%3CDT%3EJournal%3A+Letter%3C%2FDT%3E; http://ac.els-cdn.com/S1477893915002045/1-s2.0-S1477893915002045-main.pdf?_tid=3fb884c2-ffc5-11e5-bc6a-00000aab0f01&acdnat=1460366014_7f029cae69da8bbb2f04c84a69019eb5; http://ac.els-cdn.com/S1477893915002045/1-s2.0-S1477893915002045-main.pdf?_tid=c7172882-fffd-11e5-9054-00000aacb360&acdnat=1460390293_8c96abcfff1b16ac13c8fc4acda030a4,,,,,,,,Embase,April 11, 2016,No,Duplicate of existing record,,,,,,,,,,
751,"Wikan, Asian Pac J Trop Med, 2016",Wikan,"Wikan, N.; Suputtamongkol, Y.; Yoksan, S.; Smith, D. R.; Auewarakul, P.",Immunological evidence of Zika virus transmission in Thailand,Asian Pac J Trop Med,9,2,141-144,2016,2010-present,,,,2082,,http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emed13&AN=20160081413; http://lshtmsfx.hosted.exlibrisgroup.com/lshtm?sid=OVID:embase&id=pmid:&id=doi:10.1016%2Fj.apjtm.2016.01.017&issn=1995-7645&isbn=&volume=9&issue=2&spage=141&pages=141-144&date=2016&title=Asian+Pacific+Journal+of+Tropical+Medicine&atitle=Immunological+evidence+of+Zika+virus+transmission+in+Thailand&aulast=Wikan&pid=%3Cauthor%3EWikan+N.%3BSuputtamongkol+Y.%3BYoksan+S.%3BSmith+D.R.%3BAuewarakul+P.%3C%2Fauthor%3E%3CAN%3E20160081413%3C%2FAN%3E%3CDT%3EJournal%3A+Article%3C%2FDT%3E; http://ac.els-cdn.com/S1995764516000183/1-s2.0-S1995764516000183-main.pdf?_tid=2f876dac-ffc5-11e5-a378-00000aab0f26&acdnat=1460365987_a0e717157debd688c7dea002887e3753; http://ac.els-cdn.com/S1995764516000183/1-s2.0-S1995764516000183-main.pdf?_tid=9a1e6b42-fffd-11e5-9a95-00000aacb35f&acdnat=1460390218_baf38480bd6d69c52180a903719d622f,,,,,,,,Embase,April 11, 2016,No,Duplicate of existing record,,,,,,,,,,
752,"Von Eije, Ned Tijdschr Geneeskd, 2016",Von Eije,"Von Eije, K. J.; Schinkel, J.; Van Den Kerkhof, J. H. C. T.; Schreuder, I.; De Jong, M. D.; Grobusch, M. P.; Goorhuis, A.",Imported Zika virus infection in the Netherlands. [Dutch],Ned Tijdschr Geneeskd,160 (8) (no pagination),D153,,2016,2010-present,,,,2014,,http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emed13&AN=20160208666; http://lshtmsfx.hosted.exlibrisgroup.com/lshtm?sid=OVID:embase&id=pmid:&id=doi:&issn=0028-2162&isbn=&volume=160&issue=8&spage=no+pagination&pages=no+pagination&date=2016&title=Nederlands+Tijdschrift+voor+Geneeskunde&atitle=Import+van+zikavirus-infectie+in+Nederland&aulast=Von+Eije&pid=%3Cauthor%3EVon+Eije+K.J.%3BSchinkel+J.%3BVan+Den+Kerkhof+J.H.C.T.%3BSchreuder+I.%3BDe+Jong+M.D.%3BGrobusch+M.P.%3BGoorhuis+A.%3C%2Fauthor%3E%3CAN%3E20160208666%3C%2FAN%3E%3CDT%3EJournal%3A+Article%3C%2FDT%3E,,,,,,,,Embase,April 11, 2016,No,Duplicate of existing record,,,,,,,,,,
753,"Roure, Medicina Clinica, 2016",Roure,"Roure, S.; De Ory, F.; Matas, L.",Infection imported virus Zika in an area settled by Aedes albopictus. [Spanish],Medicina Clinica,146,7,332-333,2016,2010-present,,,,2095,,http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emed13&AN=20160173829; http://lshtmsfx.hosted.exlibrisgroup.com/lshtm?sid=OVID:embase&id=pmid:&id=doi:10.1016%2Fj.medcli.2016.02.003&issn=0025-7753&isbn=&volume=146&issue=7&spage=332&pages=332-333&date=2016&title=Medicina+Clinica&atitle=Infeccion+importada+por+virus+Zika+en+una+zona+colonizada+por+Aedes+albopictus&aulast=Roure&pid=%3Cauthor%3ERoure+S.%3BDe+Ory+F.%3BMatas+L.%3C%2Fauthor%3E%3CAN%3E20160173829%3C%2FAN%3E%3CDT%3EJournal%3A+Letter%3C%2FDT%3E; http://ac.els-cdn.com/S0025775316000841/1-s2.0-S0025775316000841-main.pdf?_tid=2a0de9dc-ffc5-11e5-a134-00000aab0f02&acdnat=1460365978_d8bbdbbfb593a28223e38f06934602e0; http://ac.els-cdn.com/S0025775316000841/1-s2.0-S0025775316000841-main.pdf?_tid=c1c62acc-fffd-11e5-bcef-00000aacb35f&acdnat=1460390284_e526feb3d19382909f2e2176b8ff18f1,,,,,,,,Embase,April 11, 2016,No,Duplicate of existing record,,,,,,,,,,
754,"Dupont-Rouzeyrol, Lancet, 2016",Dupont-Rouzeyrol,"Dupont-Rouzeyrol, M.; Biron, A.; O'Connor, O.; Huguon, E.; Descloux, E.",Infectious Zika viral particles in breastmilk,Lancet,387,10023,1051,2016,2010-present,,,,2061,,http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emed13&AN=20160180764; http://lshtmsfx.hosted.exlibrisgroup.com/lshtm?sid=OVID:embase&id=pmid:&id=doi:10.1016%2FS0140-6736%252816%252900624-3&issn=0140-6736&isbn=&volume=387&issue=10023&spage=1051&pages=1051&date=2016&title=The+Lancet&atitle=Infectious+Zika+viral+particles+in+breastmilk&aulast=Dupont-Rouzeyrol&pid=%3Cauthor%3EDupont-Rouzeyrol+M.%3BBiron+A.%3BO%27Connor+O.%3BHuguon+E.%3BDescloux+E.%3C%2Fauthor%3E%3CAN%3E20160180764%3C%2FAN%3E%3CDT%3EJournal%3A+Letter%3C%2FDT%3E,,,,,,,,Embase,April 11, 2016,No,Duplicate of existing record,,,,,,,,,,
755,"Freitas, Revista do Instituto de Medicina Tropical de Sao Paulo, 2016",Freitas,"Freitas, A. R. R.; Angerami, R. N.; von Zuben, A. P. B.; Donalisio, M. R.",Introduction and transmission of zika virus in Brazil: New challenges for the Americas,Revista do Instituto de Medicina Tropical de Sao Paulo,58,no pagination,,2016,2010-present,,,,2058,,http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emed13&AN=20160251125; http://lshtmsfx.hosted.exlibrisgroup.com/lshtm?sid=OVID:embase&id=pmid:&id=doi:10.1590%2FS1678-9946201658024&issn=0036-4665&isbn=&volume=58&issue=&spage=no+pagination&pages=no+pagination&date=2016&title=Revista+do+Instituto+de+Medicina+Tropical+de+Sao+Paulo&atitle=Introduction+and+transmission+of+zika+virus+in+Brazil%3A+New+challenges+for+the+Americas&aulast=Freitas&pid=%3Cauthor%3EFreitas+A.R.R.%3BAngerami+R.N.%3Bvon+Zuben+A.P.B.%3BDonalisio+M.R.%3C%2Fauthor%3E%3CAN%3E20160251125%3C%2FAN%3E%3CDT%3EJournal%3A+Letter%3C%2FDT%3E,,,,,,,,Embase,April 11, 2016,No,Duplicate of existing record,,,,,,,,,,
756,"Barzon, Eurosurveillance, 2016",Barzon,"Barzon, L.; Pacenti, M.; Berto, A.; Sinigaglia, A.; Franchin, E.; Lavezzo, E.; Brugnaro, P.; Palu, G.","Isolation of infectious zika virus from saliva and prolonged viral RNA shedding in a traveller returning from the dominican republic to Italy, January 2016",Eurosurveillance,21,10,,2016,2010-present,,,,2068,,http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emed13&AN=20160222773; http://lshtmsfx.hosted.exlibrisgroup.com/lshtm?sid=OVID:embase&id=pmid:&id=doi:10.2807%2F1560-7917&issn=1025-496X&isbn=&volume=21&issue=10&spage=no+pagination&pages=no+pagination&date=2016&title=Eurosurveillance&atitle=Isolation+of+infectious+zika+virus+from+saliva+and+prolonged+viral+RNA+shedding+in+a+traveller+returning+from+the+dominican+republic+to+Italy%2C+January+2016&aulast=Barzon&pid=%3Cauthor%3EBarzon+L.%3BPacenti+M.%3BBerto+A.%3BSinigaglia+A.%3BFranchin+E.%3BLavezzo+E.%3BBrugnaro+P.%3BPalu+G.%3C%2Fauthor%3E%3CAN%3E20160222773%3C%2FAN%3E%3CDT%3EJournal%3A+Article%3C%2FDT%3E,,,,,,,,Embase,April 11, 2016,No,Duplicate of existing record,,,,,,,,,,
757,"Rodríguez-Morales, , 2016",Rodríguez-Morales,"Rodríguez-Morales, AJ; Galindo-Marquez, ML; Garc","Mapping Zika virus infection using geographical information systems in Tolima, Colombia, 2015-2016 [version 1; referees: 1 approved]",,5,568,,2016,2010-present,,,10.12688/f1000research.8436.1,2034,,http://f1000r.es/70b,,,,,,,"Objective: Geographical information systems (GIS) have been extensively used for the development of epidemiological maps of tropical diseases, however not yet specifically for Zika virus (ZIKV) infection.  Methods: Surveillance case data of the ongoing epidemics of ZIKV in the Tolima department, Colombia (2015-2016) were used to estimate cumulative incidence rates (cases/100,000 pop.) to develop the first maps in the department and its municipalities, including detail for the capital, Ibagué. The GIS software used was Kosmo Desktop 3.0RC1®. Two thematic maps were developed according to municipality and communes incidence rates.  Results: Up to March 5, 2016, 4,094 cases of ZIKV were reported in Tolima, for cumulated rates of 289.9 cases/100,000 pop. (7.95% of the country). Burden of ZIKV infection has been concentrated in its east area, where municipalities have reported >500 cases/100,000 pop. These municipalities are bordered by two other departments, Cundinamarca (3,778 cases) and Huila (5,338 cases), which also have high incidences of ZIKV infection. Seven municipalities of Tolima ranged from 250-499.99 cases/100,000 pop., of this group five border with high incidence municipalities (>250), including the capital, where almost half of the reported cases of ZIKV in Tolima are concentrated.  Conclusions: Use of GIS-based epidemiological maps helps to  guide decisions for the prevention and control of diseases that represent significant issues in the region and the country, but also in emerging conditions such as ZIKV.",F1000,April 11, 2016,Yes,,No,"Zika, not relevant to causality framework",Scientific (journal) article,No,Original research,No,Yes,757,Clinical/epidemiological research,Ecological study/outbreak report
758,"Microcephaly Epidemic Research Group MERG, Emerg Infect Dis, 2016",Microcephaly Epidemic Research Group MERG,Microcephaly Epidemic Research Group MERG,"Microcephaly in Infants, Pernambuco State, Brazil, 2015",Emerg Infect Dis,22,http://wwwnc.cdc.gov/eid/article/22/6/16-0062_article.htm,,2016,2010-present,,,10.3201/eid2206.160062,2049,English,,,Brazil,Americas,United Kingdom,Public/Government,,"We studied the clinical characteristics for 104 infants born with microcephaly in the delivery hospitals of Pernambuco State, Brazil, during 2015. Testing is ongoing to exclude known infectious causes. However, microcephaly peaked in October and demonstrated central nervous system abnormalities with brain dysgenesis and intracranial calcifications consistent with an intrauterine infection.",EID,April 11, 2016,Yes,,Yes,,Scientific (journal) article,Yes,Original research,Yes,Yes,758,Clinical/epidemiological research,Case series
759,"Shakir, Lancet Neurol, 2016",Shakir,"Shakir, R.",Neurological expertise is essential for Zika virus infection,Lancet Neurol,15,4,353-354,2016,2010-present,,,,2089,,http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emed13&AN=20160167139; http://lshtmsfx.hosted.exlibrisgroup.com/lshtm?sid=OVID:embase&id=pmid:&id=doi:10.1016%2FS1474-4422%252816%252900072-7&issn=1474-4422&isbn=&volume=15&issue=4&spage=353&pages=353-354&date=2016&title=The+Lancet+Neurology&atitle=Neurological+expertise+is+essential+for+Zika+virus+infection&aulast=Shakir&pid=%3Cauthor%3EShakir+R.%3C%2Fauthor%3E%3CAN%3E20160167139%3C%2FAN%3E%3CDT%3EJournal%3A+Letter%3C%2FDT%3E; http://ac.els-cdn.com/S1474442216000727/1-s2.0-S1474442216000727-main.pdf?_tid=23dc93ec-ffc5-11e5-a285-00000aab0f6b&acdnat=1460365968_90612c1a437ba28bb50c7879ddf494f7; http://ac.els-cdn.com/S1474442216000727/1-s2.0-S1474442216000727-main.pdf?_tid=b1932d3a-fffd-11e5-82c4-00000aab0f6c&acdnat=1460390257_85bbae535388a62feac6e15c12feb9ee,,,,,,,,Embase,April 11, 2016,No,Duplicate of existing record,,,,,,,,,,
760,"Nabel, Science Translational Medicine, 2016",Nabel,"Nabel, G. J.; Zerhouni, E. A.",Once and future epidemics: Zika virus emerging,Science Translational Medicine,8 (330) (no pagination),330ED2,,2016,2010-present,,,,2047,,http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emed13&AN=20160239689; http://lshtmsfx.hosted.exlibrisgroup.com/lshtm?sid=OVID:embase&id=pmid:&id=doi:10.1126%2Fscitranslmed.aaf4548&issn=1946-6234&isbn=&volume=8&issue=330&spage=no+pagination&pages=no+pagination&date=2016&title=Science+Translational+Medicine&atitle=Once+and+future+epidemics%3A+Zika+virus+emerging&aulast=Nabel&pid=%3Cauthor%3ENabel+G.J.%3BZerhouni+E.A.%3C%2Fauthor%3E%3CAN%3E20160239689%3C%2FAN%3E%3CDT%3EJournal%3A+Review%3C%2FDT%3E,,,,,,,,Embase,April 11, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,760,,
761,"Althouse, bioRxiv, 2016",Althouse,"Althouse, Benjamin; Vasilakis, Nikos; Sall, Amadou; Diallo, Mawlouth; Weaver, Scott; Hanley, Kathryn",Potential for Zika virus to establish a sylvatic transmission cycle in the Americas,bioRxiv,,,,2016,2010-present,,,10.1101/047175,2149,,http://biorxiv.org/content/biorxiv/early/2016/04/05/047175.full.pdf,,,,,,,"Zika virus (ZIKV) originated and continues to circulate in a sylvatic transmission cycle between non-human primate hosts and arboreal mosquitoes in tropical Africa. Recently ZIKV invaded the Americas, where it poses a threat to human health, especially to pregnant women and their infants. Here we examine the risk that ZIKV will establish a sylvatic cycle in the Americas, focusing on Brazil. We review the natural history of sylvatic ZIKV and present a mathematical dynamic transmission model to assess the probability of establishment of a sylvatic ZIKV transmission cycle in non-human primates and/or other mammals and arboreal mosquito vectors in Brazil. Brazil is home to multiple species of primates and mosquitoes potentially capable of ZIKV transmission, though direct assessment of host competence (ability to mount viremia sufficient to infect a feeding mosquito) and vector competence (ability to become infected with ZIKV and disseminate and transmit upon subsequent feedings) of New World species is lacking. Modeling reveals a high probability of establishment of sylvatic ZIKV across a large range of biologically plausible parameters. Probability of establishment is dependent on host population sizes and birthrates and ZIKV force of infection, but a network of as few as 6,000 primates with 10,000 mosquitoes is capable of supporting establishment of a ZIKV sylvatic cycle. Research on the susceptibility of New World monkeys or other small mammals to ZIKV, on the vector competence of New World Aedes, Sabethes, and Haemagogus mosquitoes for ZIKV, and on the geographic range of these species is urgently needed. A sylvatic cycle of ZIKV would make future elimination efforts in the Americas practically impossible, and paints a dire situation for the epidemiology of ZIKV and ending the ongoing outbreak of congenital Zika syndrome.",BiorXiv,April 11, 2016,Yes,,No,"Zika, not relevant to causality framework",Scientific (journal) article,No,Original research,No,Yes,761,Clinical/epidemiological research,Modelling study
762,"Pasquini, bioRxiv, 2016",Pasquini,"Pasquini, Pedro Simoni; Simoni, Isabela Cristina",Statistical Analysis of Zika Virus Correlation to Microcephaly,bioRxiv,,,,2016,2010-present,,,10.1101/046896,2100,,http://biorxiv.org/content/biorxiv/early/2016/04/03/046896.full.pdf,,Brazil,Americas,Brazil,,,A Statistical Analysis was performed to probe the correlation between the Zika Virus (ZIKV) and its possibility to induce Microcephaly in infants. It was found that without considering a false positive on tests for ZIKV on mothers there seems to be a statistical significance on ZIKV to cause Microcephaly in infants with a probability of q=0.092 ,BiorXiv,April 11, 2016,Yes,,No,"Zika, not relevant to causality framework",Scientific (journal) article,No,Original research,No,Yes,762,Clinical/epidemiological research,Modelling study
763,"Campanati, bioRxiv, 2016",Campanati,"Campanati, Loraine; Higa, Luiza M.; Delvecchio, Rodrigo; Pezzuto, Paula; Valad",The Impact of African and Brazilian ZIKV isolates on neuroprogenitors,bioRxiv,,,,2016,2010-present,,,10.1101/046599,2141,,http://biorxiv.org/content/biorxiv/early/2016/03/31/046599.full.pdf,,Brazil,Americas,Brazil,Mixed,,"In the last few months, an overwhelming number of people have been exposed to the Zika virus (ZIKV) all over South and Central America. Healthcare professionals noticed an alarming surge of fetuses diagnosed with microcephaly and several other brain malformations from mothers who showed signs of the disease during pregnancy. There was also an increase in the number of reported cases of Guillain-Barr",BiorXiv,April 11, 2016,Yes,,Yes,,Scientific (journal) article,No,Original research,No,Yes,763,Basic and applied biomedical research,In vitro experiment
764,"Bouvier, Science Translational Medicine, 2016",Bouvier,"Bouvier, N. M.",The case against Zika virus,Science Translational Medicine,8 (329) (no pagination),329ec40,,2016,2010-present,,,,2067,,http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emed13&AN=20160212549; http://lshtmsfx.hosted.exlibrisgroup.com/lshtm?sid=OVID:embase&id=pmid:&id=doi:&issn=1946-6234&isbn=&volume=8&issue=329&spage=no+pagination&pages=no+pagination&date=2016&title=Science+Translational+Medicine&atitle=The+case+against+Zika+virus&aulast=Bouvier&pid=%3Cauthor%3EBouvier+N.M.%3C%2Fauthor%3E%3CAN%3E20160212549%3C%2FAN%3E%3CDT%3EJournal%3A+Editorial%3C%2FDT%3E,,,,,,,,Embase,April 11, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,764,,
765,"Petersen, MMWR Morb Mortal Wkly Rep, 2016",Petersen,"Petersen, Emily E.; Polen, Kara N. D.; Meaney-Delman, Dana; Ellington, Sascha R.; Oduyebo, Titilope; Cohn, Amanda; Oster, Alexandra M.; Russell, Kate; Kawwass, Jennifer F.; Karwowski, Mateusz P.; Powers, Ann M.; Bertolli, Jeanne; Brooks, John T.; Kissin, Dmitry; Villanueva, Julie; Mu",Update: Interim Guidance for Health Care Providers Caring for Women of Reproductive Age with Possible Zika Virus Exposure ,MMWR Morb Mortal Wkly Rep,65,12,315-322 %U http://www.cdc.gov/mmwr/volumes/65/wr/mm6512e2.htm,2016,2010-present,,,,2039,,,,,,,,,,CDC,April 11, 2016,No,Duplicate of existing record,,,,,,,,,,
766,"Response, MMWR Morb Mortal Wkly Rep, 2016",Response,"Response, C. D. C. Zika",Vital Signs: Preparing for Local Mosquito-Borne Transmission of Zika Virus ,MMWR Morb Mortal Wkly Rep,65,13,352 %U http://www.cdc.gov/mmwr/volumes/65/wr/mm6513e1.htm,2016,2010-present,,,,2036,,,,,,,,,,CDC,April 11, 2016,No,Duplicate of existing record,,,,,,,,,,
767,"Shan, ACS Infectious Diseases, 2016",Shan,"Shan, C.; Xie, X.; Barrett, A. D. T.; Garcia-Blanco, M. A.; Tesh, R. B.; Vasconcelos, P. F. D. C.; Vasilakis, N.; Weaver, S. C.; Shi, P. Y.","Zika Virus: Diagnosis, Therapeutics, and Vaccine",ACS Infectious Diseases,2,3,170-172,2016,2010-present,,,,2021,,http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emed13&AN=20160225537; http://lshtmsfx.hosted.exlibrisgroup.com/lshtm?sid=OVID:embase&id=pmid:&id=doi:10.1021%2Facsinfecdis.6b00030&issn=2373-8227&isbn=&volume=2&issue=3&spage=170&pages=170-172&date=2016&title=ACS+Infectious+Diseases&atitle=Zika+Virus%3A+Diagnosis%2C+Therapeutics%2C+and+Vaccine&aulast=Shan&pid=%3Cauthor%3EShan+C.%3BXie+X.%3BBarrett+A.D.T.%3BGarcia-Blanco+M.A.%3BTesh+R.B.%3BVasconcelos+P.F.D.C.%3BVasilakis+N.%3BWeaver+S.C.%3BShi+P.-Y.%3C%2Fauthor%3E%3CAN%3E20160225537%3C%2FAN%3E%3CDT%3EJournal%3A+Article%3C%2FDT%3E,,,,,,,,Embase,April 11, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,767,,
768,"Van Den Brink, Ned Tijdschr Geneeskd, 2016",Van Den Brink,"Van Den Brink, R.; Pennarts, J.",Zika and the World Health Organization: State of emergency or call for cooperation?,Ned Tijdschr Geneeskd,160,8,,2016,2010-present,,,,2016,,http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emed13&AN=20160208662; http://lshtmsfx.hosted.exlibrisgroup.com/lshtm?sid=OVID:embase&id=pmid:&id=doi:&issn=0028-2162&isbn=&volume=160&issue=8&spage=no+pagination&pages=no+pagination&date=2016&title=Nederlands+Tijdschrift+voor+Geneeskunde&atitle=Zika+en+de+WHO&aulast=Van+Den+Brink&pid=%3Cauthor%3EVan+Den+Brink+R.%3BPennarts+J.%3C%2Fauthor%3E%3CAN%3E20160208662%3C%2FAN%3E%3CDT%3EJournal%3A+Note%3C%2FDT%3E,,,,,,,,Embase,April 11, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,768,,
769,"Sarmiento-Ospina, Lancet Infect Dis, 2016",Sarmiento-Ospina,"Sarmiento-Ospina, Andrea; V",Zika virus associated deaths in Colombia,Lancet Infect Dis,,,,2016,2010-present,,,http://dx.doi.org/10.1016/S1473-3099(16)30006-8,2090,English,http://www.thelancet.com/journals/laninf/article/PIIS1473-3099%2816%2930006-8/fulltext; http://ac.els-cdn.com/S1473309916300068/1-s2.0-S1473309916300068-main.pdf?_tid=abd68a5e-fffd-11e5-8b1c-00000aab0f26&acdnat=1460390248_d913955e9bf418693a5a66ea5f6f3006,,,,,Not reported/unknown,,,Lancet,April 11, 2016,Yes,,No,"Zika, indirect evidence or other topic",Scientific (journal) article,Yes,Original research,No,Yes,769,Clinical/epidemiological research,Case series
770,"Mlakar, N Engl J Med, 2016",Mlakar,"Mlakar, J.; Korva, M.; Tul, N.; Popovic, M.; Poljsak-Prijatelj, M.; Mraz, J.; Kolenc, M.; Rus, K. R.; Vipotnik, T. V.; Vodusek, V. F.; Vizjak, A.; Pizem, J.; Petrovec, M.; Zupanc, T. A.",Zika virus associated with microcephaly,N Engl J Med,374,10,951-958,2016,2010-present,,,,2048,,http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emed13&AN=20160212218; http://lshtmsfx.hosted.exlibrisgroup.com/lshtm?sid=OVID:embase&id=pmid:&id=doi:10.1056%2FNEJMoa1600651&issn=0028-4793&isbn=&volume=374&issue=10&spage=951&pages=951-958&date=2016&title=New+England+Journal+of+Medicine&atitle=Zika+virus+associated+with+microcephaly&aulast=Mlakar&pid=%3Cauthor%3EMlakar+J.%3BKorva+M.%3BTul+N.%3BPopovic+M.%3BPoljsak-Prijatelj+M.%3BMraz+J.%3BKolenc+M.%3BRus+K.R.%3BVipotnik+T.V.%3BVodusek+V.F.%3BVizjak+A.%3BPizem+J.%3BPetrovec+M.%3BZupanc+T.A.%3C%2Fauthor%3E%3CAN%3E20160212218%3C%2FAN%3E%3CDT%3EJournal%3A+Article%3C%2FDT%3E,,,,,,,,Embase,April 11, 2016,No,Duplicate of existing record,,,,,,,,,,
771,"Marcondes, Revista da Sociedade Brasileira de Medicina Tropical, 2016",Marcondes,"Marcondes, C. B.; Ximenes, M. F. F. M.",Zika virus in Brazil and the danger of infestation by aedes (Stegomyia) mosquitoes,Revista da Sociedade Brasileira de Medicina Tropical,49,1,04. Okt,2016,2010-present,,,,2050,,http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emed13&AN=20160238012; http://lshtmsfx.hosted.exlibrisgroup.com/lshtm?sid=OVID:embase&id=pmid:&id=doi:10.1590%2F0037-8682-0220-2015&issn=0037-8682&isbn=&volume=49&issue=1&spage=4&pages=4-10&date=2016&title=Revista+da+Sociedade+Brasileira+de+Medicina+Tropical&atitle=Zika+virus+in+Brazil+and+the+danger+of+infestation+by+aedes+%28Stegomyia%29+mosquitoes&aulast=Marcondes&pid=%3Cauthor%3EMarcondes+C.B.%3BXimenes+M.F.F.M.%3C%2Fauthor%3E%3CAN%3E20160238012%3C%2FAN%3E%3CDT%3EJournal%3A+Review%3C%2FDT%3E,,,,,,,,Embase,April 11, 2016,No,Duplicate of existing record,,,,,,,,,,
772,"Zumla, Int J Infect Dis, 2016",Zumla,"Zumla, A.; Goodfellow, I.; Kasolo, F.; Ntoumi, F.; Buchy, P.; Bates, M.; Azhar, E. I.; Cotten, M.; Petersen, E.",Zika virus outbreak and the case for building effective and sustainable rapid diagnostics laboratory capacity globally,Int J Infect Dis,45,,92-94,2016,2010-present,,,,2080,,http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emed13&AN=20160225147; http://lshtmsfx.hosted.exlibrisgroup.com/lshtm?sid=OVID:embase&id=pmid:&id=doi:10.1016%2Fj.ijid.2016.02.1007&issn=1201-9712&isbn=&volume=45&issue=&spage=92&pages=92-94&date=2016&title=International+Journal+of+Infectious+Diseases&atitle=Zika+virus+outbreak+and+the+case+for+building+effective+and+sustainable+rapid+diagnostics+laboratory+capacity+globally&aulast=Zumla&pid=%3Cauthor%3EZumla+A.%3BGoodfellow+I.%3BKasolo+F.%3BNtoumi+F.%3BBuchy+P.%3BBates+M.%3BAzhar+E.I.%3BCotten+M.%3BPetersen+E.%3C%2Fauthor%3E%3CAN%3E20160225147%3C%2FAN%3E%3CDT%3EJournal%3A+Editorial%3C%2FDT%3E; http://ac.els-cdn.com/S1201971216309869/1-s2.0-S1201971216309869-main.pdf?_tid=1386c008-ffc5-11e5-8870-00000aab0f27&acdnat=1460365940_2d0215425f27435a65ba0bb016305fa2; http://ac.els-cdn.com/S1201971216309869/1-s2.0-S1201971216309869-main.pdf?_tid=95494420-fffd-11e5-be91-00000aacb362&acdnat=1460390210_1e029290e048a1397797043869304c07,,,,,,,,Embase,April 11, 2016,No,Duplicate of existing record,,,,,,,,,,
773,"Ribeiro, Revista da Sociedade Brasileira de Medicina Tropical, 2016",Ribeiro,"Ribeiro, G. S.; Kitron, U.",Zika virus pandemic: A human and public health crisis,Revista da Sociedade Brasileira de Medicina Tropical,49,1,01. Mrz,2016,2010-present,,,,2035,,http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emed13&AN=20160238011; http://lshtmsfx.hosted.exlibrisgroup.com/lshtm?sid=OVID:embase&id=pmid:&id=doi:10.1590%2F0037-8682-0036-2016&issn=0037-8682&isbn=&volume=49&issue=1&spage=1&pages=1-3&date=2016&title=Revista+da+Sociedade+Brasileira+de+Medicina+Tropical&atitle=Zika+virus+pandemic%3A+A+human+and+public+health+crisis&aulast=Ribeiro&pid=%3Cauthor%3ERibeiro+G.S.%3BKitron+U.%3C%2Fauthor%3E%3CAN%3E20160238011%3C%2FAN%3E%3CDT%3EJournal%3A+Editorial%3C%2FDT%3E,,,,,,,,Embase,April 11, 2016,No,Duplicate of existing record,,,,,,,,,,
774,"Hajra, North American Journal of Medical Sciences, 2016",Hajra,"Hajra, A.; Bandyopadhyay, D.; Hajra, S. K.",Zika virus: A global threat to humanity: A comprehensive review and current developments,North American Journal of Medical Sciences,8,3,123-128,2016,2010-present,,,,2057,,http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emed13&AN=20160244012; http://lshtmsfx.hosted.exlibrisgroup.com/lshtm?sid=OVID:embase&id=pmid:&id=doi:10.4103%2F1947-2714.179112&issn=2250-1541&isbn=&volume=8&issue=3&spage=123&pages=123-128&date=2016&title=North+American+Journal+of+Medical+Sciences&atitle=Zika+virus%3A+A+global+threat+to+humanity%3A+A+comprehensive+review+and+current+developments&aulast=Hajra&pid=%3Cauthor%3EHajra+A.%3BBandyopadhyay+D.%3BHajra+S.K.%3C%2Fauthor%3E%3CAN%3E20160244012%3C%2FAN%3E%3CDT%3EJournal%3A+Review%3C%2FDT%3E,,,,,,,"At present, one of greatest concerns of medical personnel is Zika virus (ZIKV). Though it has been reported for quite a long time, its rapid emergence, new modes of transmission, and more importantly, the congenital anomalies associated with it have made the situation worse. It was first detected in 1947. After that, this infection was found in the countries of Africa as well as Asia. At present, interestingly it has been reported from Brazil. Microcephaly and intracranial calcification have been postulated to be related to maternal infection with this virus. Though it is asymptomatic in maximum number of cases, the serious complications of the infection should be prevented at the earliest. No specific treatment and vaccine are available till now. But research continues and hopefully, success is not far off. The right information about this infection should reach patients as well as physicians. It will prevent unnecessary panic. In August, Brazil is going to organize the Olympic and Paralympic Games and all eyes are now focused on this. In this review article, the authors have tried to focus on the important points about this infection. The data were gathered after searching for relevant articles published in PubMed, the World Health Organization's (WHO) website, Centers for Disease Control and Prevention's (CDC) website, and some other related websites on the Internet.",Embase,April 11, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Yes,Review,No,Yes,774,Clinical/epidemiological research,Epidemiological/clinical review
775,"[No authors listed], Lancet Neurol, 2016",[No authors listed],[No authors listed],"Zika virus: A little less speculation, a little more action",Lancet Neurol,15,4,343,2016,2010-present,,,,2070,,http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emed13&AN=20160167129; http://lshtmsfx.hosted.exlibrisgroup.com/lshtm?sid=OVID:embase&id=pmid:&id=doi:10.1016%2FS1474-4422%252816%252900074-0&issn=1474-4422&isbn=&volume=15&issue=4&spage=343&pages=343&date=2016&title=The+Lancet+Neurology&atitle=Zika+virus%3A+A+little+less+speculation%2C+a+little+more+action&aulast=neurology&pid=%3Cauthor%3Eanonymous%3C%2Fauthor%3E%3CAN%3E20160167129%3C%2FAN%3E%3CDT%3EJournal%3A+Editorial%3C%2FDT%3E,,,,,,,,Embase,April 11, 2016,No,Duplicate of existing record,,,,,,,,,,
776,"Balkhair, Oman Medical Journal, 2016",Balkhair,"Balkhair, A.; Al-Maamari, K.; Ba Alawi, F.; Al-Adawi, B.",Zika virus: A roar after years of whispering,Oman Medical Journal,31,2,87-88,2016,2010-present,,,,2069,,http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emed13&AN=20160234145; http://lshtmsfx.hosted.exlibrisgroup.com/lshtm?sid=OVID:embase&id=pmid:&id=doi:10.5001%2Fomj.2016.18&issn=1999-768X&isbn=&volume=31&issue=2&spage=87&pages=87-88&date=2016&title=Oman+Medical+Journal&atitle=Zika+virus%3A+A+roar+after+years+of+whispering&aulast=Balkhair&pid=%3Cauthor%3EBalkhair+A.%3BAl-Maamari+K.%3BBa+Alawi+F.%3BAl-Adawi+B.%3C%2Fauthor%3E%3CAN%3E20160234145%3C%2FAN%3E%3CDT%3EJournal%3A+Editorial%3C%2FDT%3E,,,,,,,,Embase,April 11, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,776,,
779,"Zika experimental science team (ZEST), , 2016",Zika experimental science team (ZEST),Zika experimental science team (ZEST),ZIKV-003 and ZIKV-005: Infection with French Polynesian and Asian lineage Zika virus during the first pregnancy trimester,,,,,2016,2010-present,,,,2153,English,https://zika.labkey.com/project/OConnor/ZIKV-003/begin.view?,,United States,Americas,United States,Public/Government,,,Other,April 11, 2016,Yes,,Yes,,Biological database,,,No,Yes,779,Basic and applied biomedical research,Animal experiment
780,"PAHO, Epidemiological update 21 April 2016, 2016",PAHO,PAHO,Epidemiological update 21 April 2016,,Epidemiological update 21 April 2016,,,2016,2010-present,,,,2160,English,http://www.paho.org/hq/index.php?option=com_content&view=category&layout=blog&id=1218&Itemid=2291,,United States,Americas,,Public/Government,,,PAHO,April 11, 2016,Yes,,Yes,,Surveillance report or data,,,No,Yes,780,Clinical/epidemiological research,Ecological study/outbreak report
781,"PAHO, Epidemiological update. Zika virus infection - 21 April 2016, 2016",PAHO,PAHO,Epidemiological update. Zika virus infection - 21 April 2016,,Epidemiological update. Zika virus infection - 21 April 2016,,,2016,2010-present,,,,2161,,http://www.paho.org/hq/index.php?option=com_content&view=category&layout=blog&id=1218&Itemid=2291,,United States,Americas,,Public/Government,,,PAHO,April 11, 2016,Yes,,Yes,,Surveillance report or data,,,No,Yes,781,Clinical/epidemiological research,Ecological study/outbreak report
782,"PAHO, Epidemiological update. Zika virus infection - 28 April 2016, 2016",PAHO,PAHO,Epidemiological update. Zika virus infection - 28 April 2016,,Epidemiological update. Zika virus infection - 28 April 2016,,,2016,2010-present,,,,2162,English,http://www.paho.org/hq/index.php?option=com_content&view=category&layout=blog&id=1218&Itemid=2291,,United States,Americas,,Public/Government,,,PAHO,March 31, 2016,Yes,,Yes,,Surveillance report or data,,,No,Yes,782,Clinical/epidemiological research,Ecological study/outbreak report
783,"InVS, Point Epidemiologique CIRE Antilles Guyane, 2016",InVS,InVS,Point épidémio: Emergence du virus zika aux Antilles Guyane : Situation épidémiologique - 21 avril 2016,Point Epidemiologique CIRE Antilles Guyane,15,,,2016,2010-present,,,,,French,http://www.invs.sante.fr/fr/Publications-et-outils/Points-epidemiologiques/Tous-les-numeros/Antilles-Guyane/2016/Situation-epidemiologique-du-virus-Zika-aux-Antilles-Guyane.-Point-au-21-avril-2016,,France,Europe,,Public/Government,,,Institute de veille sanitaire,April 11, 2016,Yes,,No,"Zika, indirect evidence or other topic",Surveillance report or data,,,No,Yes,783,Clinical/epidemiological research,Case report
784,"InVS, Point Epidemiologique CIRE Antilles Guyane, 2016",InVS,InVS,Point épidémio: Emergence du virus zika aux Antilles Guyane : Situation épidémiologique - 14 avril 2016  ,Point Epidemiologique CIRE Antilles Guyane,14,,,2016,2010-present,April 15, 2016,,,,French,,,France,Europe,,Public/Government,,,Institute de veille sanitaire,April 11, 2016,Yes,,No,"Zika, indirect evidence or other topic",Surveillance report or data,,,No,Yes,784,Clinical/epidemiological research,Qualitative study
785,"Castellanos, Rev. salud bosque, 2015",Castellanos,"Castellanos, Jaime E.","Virus de Zika, otro dolor de cabeza para la salud pública^ies",Rev. salud bosque,5,2,115-118,2015,2010-present,,,,2255,,http://www.uelbosque.edu.co/sites/default/files/publicaciones/revistas/revista_salud_bosque/volumen5_numero2/012_Articulo10_Vol5_No2.pdf,,,,,,INFECCION POR EL VIRUS ZIKA; Public Health; Colombia; Humans,,LILACS,May 30, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,785,,
786,"Schmidt-Chanasit, MMW Fortschr Med, 2016",Schmidt-Chanasit,"Schmidt-Chanasit, J.; Schumacher, B.",[Travel warning due to Zika viruses],MMW Fortschr Med,158,2,8,2016,2010-present,March 11, 2016,26961015,10.1007/s15006-016-7725-z,2503,German,http://www.ncbi.nlm.nih.gov/pubmed/26961015,,,,,,"Aedes/virology; Animals; Brazil; Epidemics/*prevention & control; Female; Humans; Infant, Newborn; Pregnancy; Pregnancy Complications, Infectious/*prevention & control; *Travel Medicine; Zika Virus Infection/*prevention & control/transmission",,Pubmed,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,786,,
787,"Nau, Rev Med Suisse, 2016",Nau,"Nau, J. Y.","[Miscellaneous News on Religion, Entomology and Suicides]",Rev Med Suisse,12,507,422-3,2016,2010-present,April 5, 2016,27039616,,2491,French,http://www.ncbi.nlm.nih.gov/pubmed/27039616,,,,,,Animals; Confidentiality/ethics/legislation & jurisprudence; Disease Vectors; Entomology/methods/trends; Homicide/psychology; Humans; Mosquito Control; *Religion and Medicine; *Suicide/psychology; *Zika Virus/pathogenicity/physiology,,Pubmed,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,787,,
788,"Nau, Rev Med Suisse, 2016",Nau,"Nau, J. Y.",[Zika: A Physiopathological and Epidemiological Equation with Multiple Unknown Factors ],Rev Med Suisse,12,505,322-3,2016,2010-present,April 5, 2016,27039447,,2468,French,http://www.ncbi.nlm.nih.gov/pubmed/27039447,,,,,,"Animals; Communicable Diseases, Emerging/epidemiology/pathology/prevention &; control/transmission; Culicidae/virology; Female; Humans; Infectious Disease Transmission, Vertical/prevention & control/statistics &; numerical data; Pregnancy; Sexually Transmitted Diseases, Viral/epidemiology/prevention & control; World Health Organization/organization & administration; Zika Virus Infection/*epidemiology/*pathology/transmission",,Pubmed,May 30, 2016,No,Duplicate of existing record,,,,,,,,,,
789,"Betancourt-Trejos, Travel Med Infect Dis, 2016",Betancourt-Trejos,"Betancourt-Trejos, M. L.; Narvaez-Maldonado, C. F.; Ortiz-Erazo, W. F.; Arias-Guzman, J. S.; Gil-Restrepo, A. F.; Sanchez-Rueda, M. A.; Munoz-Calle, N. J.; Maya-Betancourth, J. G.; Rodriguez-Morales, A. J.",Healthcare students and workers' knowledge about Zika and its association with microcephaly in two cities of Colombia,Travel Med Infect Dis,14,3,283-5,2016,2010-present,April 12, 2016,27063652,10.1016/j.tmaid.2016.03.017,2344,English,http://www.ncbi.nlm.nih.gov/pubmed/27063652,"Public Health and Infection Research Incubator and Group, Faculty of Health Sciences, Universidad Tecnologica de Pereira, Pereira, Risaralda, Colombia.; Public Health and Infection Research Incubator and Group, Faculty of Health Sciences, Universidad Tecnologica de Pereira, Pereira, Risaralda, Colombia; Working Group on Zoonoses, International Society for Chemotherapy, Aberdeen, UK; Committee on Travel Medicine, Pan-American Association of Infectious Diseases, Quito, Ecuador; Committee on Zoonoses and Haemorrhagic Fevers, Asociacion Colombiana de Infectologia, Bogota, DC, Colombia. Electronic address: arodriguezm@utp.edu.co.",,,,,Healthcare workers; Knowledge; Medical education; Microcephaly; Zika,,Pubmed,May 30, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Unknown/unclear,Original research,No,Yes,789,Clinical/epidemiological research,Qualitative study
790,"Rodriguez-Morales, Travel Med Infect Dis, 2016",Rodriguez-Morales,"Rodriguez-Morales, A. J.; Garcia-Loaiza, C. J.; Galindo-Marquez, M. L.; Sabogal-Roman, J. A.; Marin-Loaiza, S.; Lozada-Riascos, C. O.; Diaz-Quijano, F. A.","Zika infection GIS-based mapping suggest high transmission activity in the border area of La Guajira, Colombia, a northeastern coast Caribbean department, 2015-2016: Implications for public health, migration and travel",Travel Med Infect Dis,14,3,286-8,2016,2010-present,April 12, 2016,27063653,10.1016/j.tmaid.2016.03.018,2527,English,http://www.ncbi.nlm.nih.gov/pubmed/27063653,"Public Health and Infection Research Group, Faculty of Health Sciences, Universidad Tecnologica de Pereira, Pereira, Risaralda, Colombia; Organizacion Latinoamericana para el Fomento de la Investigacion en Salud (OLFIS), Riohacha, La Guajira, Colombia. Electronic address: arodriguezm@utp.edu.co.; Public Health and Infection Research Group, Faculty of Health Sciences, Universidad Tecnologica de Pereira, Pereira, Risaralda, Colombia.; Regional Information System, Universidad Tecnologica de Pereira, Pereira, Risaralda, Colombia.; Department of Epidemiology, Faculty of Public Health, Universidade de Sao Paulo, Av. Dr. Arnaldo, 715, Cerqueira Cesar, CEP 01246-904, Sao Paulo, SP, Brazil.",,,,,Colombia; Epidemiology; Latin America; Travelers; Zika,,Pubmed,May 30, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,790,,
791,"Bocanegra, Clin Microbiol Infect, 2016",Bocanegra,"Bocanegra, C.; Sulleiro, E.; Soriano-Arandes, A.; Pou, D.; Suy, A.; Llurba, E.; Rodo, C.; Espasa, M.; Campins, M.; Martin, A.; Rodrigo, C.; Vazquez, A.; De Ory, F.; Sanchez-Seco, M. P.; Pumarola, T.; Carreras, E.; Molina, I.","Zika virus infection in pregnant women in Barcelona, Spain",Clin Microbiol Infect,,,,2016,2010-present,April 12, 2016,27063354,10.1016/j.cmi.2016.03.025,2297,English,http://www.ncbi.nlm.nih.gov/pubmed/27063354,"Tropical Medicine and International Health Unit, Vall d'Hebron-Drassanes, PROSICS Barcelona, Barcelona, Spain. Electronic address: cristinabocanegra@gmail.com.; Microbiology Department, University Hospital Vall d'Hebron, PROSICS Barcelona, Barcelona, Spain.; Pediatrics Department, Tropical Medicine and International Health Unit, Vall d'Hebron-Drassanes, PROSICS Barcelona, Barcelona, Spain.; Tropical Medicine and International Health Unit, Vall d'Hebron-Drassanes, PROSICS Barcelona, Barcelona Spain.; Gynecology and Obstetrics Department, University Hospital Vall d'Hebron, Barcelona, Spain.; Microbiology Department, Vall d'Hebron University Hospital, PROSICS Barcelona, Barcelona, Spain.; Preventive Medicine and Epidemiology Department, Vall d'Hebron University Hospital, Barcelona, Spain.; Pediatrics Department, Vall d'Hebron University Hospital, Barcelona, Spain.; National Microbiology Center, Instituto de Salud Carlos III, Madrid, Spain.; Microbiology Department, Vall d'Hebron University Hospital, Barcelona, Spain.; Gynecology and Obstetrics Department, Vall d'Hebron University Hospital, Barcelona, Spain.; Infectious Diseases Department, Vall d'Hebron University Hospital, PROSICS Barcelona, Barcelona Spain.",Spain,Europe,Spain,,,,Pubmed,May 30, 2016,Yes,,No,"Zika, not relevant to causality framework",Scientific (journal) article,Unknown/unclear,Original research,No,Yes,791,Clinical/epidemiological research,Case series
792,"Plourde, Emerg Infect Dis, 2016",Plourde,"Plourde, A. R.; Bloch, E. M.",A Literature Review of Zika Virus,Emerg Infect Dis,22,7,1185-92,2016,2010-present,April 14, 2016,27070380,10.3201/eid2207.151990,2538,English,http://www.ncbi.nlm.nih.gov/pubmed/27070380,,,,,,Aedes; Zika virus; arbovirus; craniofacial abnormalities; emerging infectious diseases; flavivirus; microcephaly; mosquitoes; review literature as topic; viruses; zoonoses,"Zika virus is a mosquitoborne flavivirus that is the focus of an ongoing pandemic and public health emergency. Previously limited to sporadic cases in Africa and Asia, the emergence of Zika virus in Brazil in 2015 heralded rapid spread throughout the Americas. Although most Zika virus infections are characterized by subclinical or mild influenza-like illness, severe manifestations have been described, including Guillain-Barre syndrome in adults and microcephaly in babies born to infected mothers. Neither an effective treatment nor a vaccine is available for Zika virus; therefore, the public health response primarily focuses on preventing infection, particularly in pregnant women. Despite growing knowledge about this virus, questions remain regarding the virus's vectors and reservoirs, pathogenesis, genetic diversity, and potential synergistic effects of co-infection with other circulating viruses. These questions highlight the need for research to optimize surveillance, patient management, and public health intervention in the current Zika virus epidemic.",Pubmed,May 30, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Review,No,Yes,792,Clinical/epidemiological research,Epidemiological/clinical review
793,"Lazear, Cell Host Microbe, 2016",Lazear,"Lazear, H. M.; Govero, J.; Smith, A. M.; Platt, D. J.; Fernandez, E.; Miner, J. J.; Diamond, M. S.",A Mouse Model of Zika Virus Pathogenesis,Cell Host Microbe,19,5,720-30,2016,2010-present,April 14, 2016,27066744,10.1016/j.chom.2016.03.010,2396,English,http://www.ncbi.nlm.nih.gov/pubmed/27066744,"Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.; Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.; Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA; The Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address: diamond@borcim.wustl.edu.",United States,Americas,United States,Mixed,,"The ongoing Zika virus (ZIKV) epidemic and unexpected clinical outcomes, including Guillain-Barre syndrome and birth defects, has brought an urgent need for animal models. We evaluated infection and pathogenesis with contemporary and historical ZIKV strains in immunocompetent mice and mice lacking components of the antiviral response. Four- to six-week-old Irf3(-/-)Irf5(-/-)Irf7(-/-) triple knockout mice, which produce little interferon alpha/beta, and mice lacking the interferon receptor (Ifnar1(-/-)) developed neurological disease and succumbed to ZIKV infection, whereas single Irf3(-/-), Irf5(-/-), and Mavs(-/-) knockout mice exhibited no overt illness. Ifnar1(-/-) mice sustained high viral loads in the brain and spinal cord, consistent with evidence that ZIKV causes neurodevelopmental defects in human fetuses. The testes of Ifnar1(-/-) mice had the highest viral loads, which is relevant to sexual transmission of ZIKV. This model of ZIKV pathogenesis will be valuable for evaluating vaccines and therapeutics as well as understanding disease pathogenesis.",Pubmed,May 30, 2016,Yes,,Yes,,Scientific (journal) article,Yes,Original research,No,Yes,793,Basic and applied biomedical research,Animal experiment
794,"PAHO, , 2016",PAHO,PAHO,Epidemiological Update. Zika virus infection - 14 April 2016,,,,,2016,2010-present,April 14, 2016,,,2703,,http://www.paho.org/hq/index.php?option=com_docman&task=doc_view&Itemid=270&gid=34183&lang=en,,United States,Americas,,Public/Government,,,PAHO,May 30, 2016,No,Duplicate of existing record,,,,,,,,,,
795,"Nah, PeerJ, 2016",Nah,"Nah, K.; Mizumoto, K.; Miyamatsu, Y.; Yasuda, Y.; Kinoshita, R.; Nishiura, H.",Estimating risks of importation and local transmission of Zika virus infection,PeerJ,4,,e1904,2016,2010-present,April 14, 2016,27069825,10.7717/peerj.1904,2563,English,http://www.ncbi.nlm.nih.gov/pubmed/27069825,"Graduate School of Medicine, The University of Tokyo, Tokyo, Japan; CREST, Japan Science and Technology Agency, Saitama, Japan; Graduate School of Medicine, Hokkaido University, Sapporo, Japan.; Graduate School of Medicine, The University of Tokyo, Tokyo, Japan; Graduate School of Medicine, Hokkaido University, Sapporo, Japan; Graduate School of Arts and Sciences, The University of Tokyo, Tokyo, Japan.; Graduate School of Medicine, The University of Tokyo , Tokyo , Japan.",,,,,Epidemiology; Importation; Mathematical model; Network; Risk; Statistical estimation; Transmission; Zika virus,"Background. An international spread of Zika virus (ZIKV) infection has attracted global attention. ZIKV is conveyed by a mosquito vector, Aedes species, which also acts as the vector species of dengue and chikungunya viruses. Methods. Arrival time of ZIKV importation (i.e., the time at which the first imported case was diagnosed) in each imported country was collected from publicly available data sources. Employing a survival analysis model in which the hazard is an inverse function of the effective distance as informed by the airline transportation network data, and using dengue and chikungunya virus transmission data, risks of importation and local transmission were estimated. Results. A total of 78 countries with imported case(s) have been identified, with the arrival time ranging from 1 to 44 weeks since the first ZIKV was identified in Brazil, 2015. Whereas the risk of importation was well explained by the airline transportation network data, the risk of local transmission appeared to be best captured by additionally accounting for the presence of dengue and chikungunya viruses. Discussion. The risk of importation may be high given continued global travel of mildly infected travelers but, considering that the public health concerns over ZIKV infection stems from microcephaly, it is more important to focus on the risk of local and widespread transmission that could involve pregnant women. The predicted risk of local transmission was frequently seen in tropical and subtropical countries with dengue or chikungunya epidemic experience.",Pubmed,May 30, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,No,Original research,No,Yes,795,Clinical/epidemiological research,Modelling study
796,"D'Ortenzio, N Engl J Med, 2016",D'Ortenzio,"D'Ortenzio, E.; Matheron, S.; Yazdanpanah, Y.; de Lamballerie, X.; Hubert, B.; Piorkowski, G.; Maquart, M.; Descamps, D.; Damond, F.; Leparc-Goffart, I.",Evidence of Sexual Transmission of Zika Virus,N Engl J Med,374,22,2195-8,2016,2010-present,April 14, 2016,27074370,10.1056/NEJMc1604449,2454,English,http://www.ncbi.nlm.nih.gov/pubmed/27074370,"Institut National de la Sante et de la Recherche Medicale, Paris, France.; Hopital Bichat Assistance Publique-Hopitaux de Paris, Paris, France.; Institut National de la Sante et de la Recherche Medicale, Paris, France yazdan.yazdanpanah@aphp.fr.; Universite Aix-Marseille, Marseille, France.; Institut de Veille Sanitaire, Saint Maurice, France.; French Armed Forces Biomedical Research Institute, Marseille, France.",,,,,"Disease Transmission, Infectious; Humans; Middle Aged; Phylogeny; RNA, Viral/analysis/urine; Saliva/virology; Semen/virology; *Sexually Transmitted Diseases, Viral; Urine/virology; Young Adult; Zika Virus/*genetics/isolation & purification; Zika Virus Infection/*transmission",,Pubmed,May 30, 2016,Yes,,No,"Zika, not relevant to causality framework",Scientific (journal) article,Unknown/unclear,Original research,No,Yes,796,Clinical/epidemiological research,Case report
797,"Gostin, JAMA, 2016",Gostin,"Gostin, L. O.; Hodge, J. G., Jr.",Is the United States Prepared for a Major Zika Virus Outbreak?,JAMA,315,22,2395-6,2016,2010-present,April 14, 2016,27074330,10.1001/jama.2016.4919,2412,English,http://www.ncbi.nlm.nih.gov/pubmed/27074330,"O'Neill Institute for National and Global Health Law, Georgetown University Law Center, Washington, DC.; Public Health Law and Policy Program, Sandra Day O'Connor College of Law, Arizona State University, Tempe.",,,,,"Asymptomatic Infections; Centers for Disease Control and Prevention (U.S.); Contraception; Disease Outbreaks/*prevention & control; Female; Financing, Government/economics; Humans; Mosquito Control/methods; Pregnancy; United States/epidemiology; *Zika Virus; Zika Virus Infection/epidemiology/*prevention & control/transmission",,Pubmed,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,797,,
798,"Jin, JAMA, 2016",Jin,"Jin, J.",JAMA PATIENT PAGE. Zika Virus Disease,JAMA,315,22,2482,2016,2010-present,April 14, 2016,27074312,10.1001/jama.2016.4741,2373,English,http://www.ncbi.nlm.nih.gov/pubmed/27074312,,,,,,"Asymptomatic Infections/epidemiology; Caribbean Region/epidemiology; Central America/epidemiology; Disease Outbreaks; Female; Humans; Infant, Newborn; Male; Microcephaly/virology; Pregnancy; South America/epidemiology; *Zika Virus; *Zika Virus Infection/complications/diagnosis/epidemiology/prevention &; control/transmission",,Pubmed,May 30, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Unknown/unclear,Original research,No,Yes,798,Clinical/epidemiological research,Guidelines
799,"Fontes, Neuroradiology, 2016",Fontes,"Fontes, C. A.; Dos Santos, A. A.; Marchiori, E.",Magnetic resonance imaging findings in Guillain-Barre syndrome caused by Zika virus infection,Neuroradiology,,,,2016,2010-present,April 14, 2016,27067205,10.1007/s00234-016-1687-9,2382,English,http://www.ncbi.nlm.nih.gov/pubmed/27067205,"Department of Radiology, Federal Fluminense University, Rio de Janeiro, Brazil.; Department of Radiology, Federal University of Rio de Janeiro, Rua Thomaz Cameron, 438, Valparaiso, CEP 25685.120, Petropolis, Rio de Janeiro, Brazil. edmarchiori@gmail.com.",Brazil,Americas,Brazil,Not reported/unknown,,,Pubmed,May 30, 2016,Yes,,Yes,,Scientific (journal) article,Unknown/unclear,Original research,No,Yes,799,Clinical/epidemiological research,Case report
800,"Bayer, Cell Host Microbe, 2016",Bayer,"Bayer, A.; Lennemann, N. J.; Ouyang, Y.; Bramley, J. C.; Morosky, S.; Marques, E. T., Jr.; Cherry, S.; Sadovsky, Y.; Coyne, C. B.",Type III Interferons Produced by Human Placental Trophoblasts Confer Protection against Zika Virus Infection,Cell Host Microbe,19,5,705-12,2016,2010-present,April 14, 2016,27066743,10.1016/j.chom.2016.03.008,2358,English,http://www.ncbi.nlm.nih.gov/pubmed/27066743,"Magee-Womens Research Institute, University of Pittsburgh, Pittsburgh, PA 15213, USA; Department of Obstetrics, Gynecology, and Reproductive Science, University of Pittsburgh, Pittsburgh, PA 15213, USA.; Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, PA 15219, USA.; Center for Vaccine Research, University of Pittsburgh, Pittsburgh, PA 15261, USA; Fundacao Osvaldo Cruz - FIOCRUZ, Recife, Pernambuco 50670-420, Brazil.; Department of Microbiology, University of Pennsylvania, Philadelphia, PA 19104, USA.; Magee-Womens Research Institute, University of Pittsburgh, Pittsburgh, PA 15213, USA; Department of Obstetrics, Gynecology, and Reproductive Science, University of Pittsburgh, Pittsburgh, PA 15213, USA; Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, PA 15219, USA. Electronic address: ysadovsky@mwri.magee.edu.; Magee-Womens Research Institute, University of Pittsburgh, Pittsburgh, PA 15213, USA; Department of Obstetrics, Gynecology, and Reproductive Science, University of Pittsburgh, Pittsburgh, PA 15213, USA; Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, PA 15219, USA. Electronic address: coynec2@pitt.edu.",United States,Americas,United States,Public/Government,IFNlambda; Zika virus; placenta; trophoblasts; type III interferon; virus,"During mammalian pregnancy, the placenta acts as a barrier between the maternal and fetal compartments. The recently observed association between Zika virus (ZIKV) infection during human pregnancy and fetal microcephaly and other anomalies suggests that ZIKV may bypass the placenta to reach the fetus. This led us to investigate ZIKV infection of primary human trophoblasts (PHTs), which are the barrier cells of the placenta. We discovered that PHT cells from full-term placentas are refractory to ZIKV infection. In addition, medium from uninfected PHT cells protects non-placental cells from ZIKV infection. PHT cells constitutively release the type III interferon (IFN) IFNlambda1, which functions in both a paracrine and autocrine manner to protect trophoblast and non-trophoblast cells from ZIKV infection. Our data suggest that for ZIKV to access the fetal compartment, it must evade restriction by trophoblast-derived IFNlambda1 and other trophoblast-specific antiviral factors and/or use alternative strategies to cross the placental barrier.",Pubmed,May 30, 2016,Yes,,Yes,,Scientific (journal) article,Yes,Original research,No,Yes,800,Basic and applied biomedical research,In vitro experiment
801,"McCarthy, BMJ, 2016",McCarthy,"McCarthy, M.",US health officials press Congress for $1.9bn to combat Zika,BMJ,352,,i2106,2016,2010-present,April 14, 2016,27073228,10.1136/bmj.i2106,2437,English,http://www.ncbi.nlm.nih.gov/pubmed/27073228,Seattle.,,,,,,,Pubmed,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,News item or lay press,,,No,Yes,801,,
802,"Du Toit, Nat Rev Microbiol, 2016",Du Toit,"Du Toit, A.","Viral infection: Zika virus structure, epidemiology and evolution",Nat Rev Microbiol,14,5,267,2016,2010-present,April 14, 2016,27067402,10.1038/nrmicro.2016.55,2443,English,http://www.ncbi.nlm.nih.gov/pubmed/27067402,,,,,,,,Pubmed,May 30, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,802,,
803,"Brasil, PLoS Negl Trop Dis, 2016",Brasil,"Brasil, P.; Calvet, G. A.; Siqueira, A. M.; Wakimoto, M.; de Sequeira, P. C.; Nobre, A.; Quintana Mde, S.; Mendonca, M. C.; Lupi, O.; de Souza, R. V.; Romero, C.; Zogbi, H.; Bressan Cda, S.; Alves, S. S.; Lourenco-de-Oliveira, R.; Nogueira, R. M.; Carvalho, M. S.; de Filippis, A. M.; Jaenisch, T.","Zika Virus Outbreak in Rio de Janeiro, Brazil: Clinical Characterization, Epidemiological and Virological Aspects",PLoS Negl Trop Dis,10,4,e0004636,2016,2010-present,April 14, 2016,27070912,10.1371/journal.pntd.0004636,2304,English,http://www.ncbi.nlm.nih.gov/pubmed/27070912,"Acute Febrile Illnesses Laboratory, Evandro Chagas National Institute of Infectious Diseases; Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, Brazil.; Flavivirus Laboratory, Oswaldo Cruz Institute/ Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, Brazil.; Scientific Computation Program, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, Brazil.; Clinical Research Platform, Evandro Chagas National Institute of Infectious Diseases; Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, Brazil.; Mosquito Transmitters of Hematozoans Laboratory, Oswaldo Cruz Institute/ Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, Brazil.; Section Clinical Tropical Medicine, Department of Infectious Diseases, Heidelberg University Hospital, Heidelberg, Germany & German Center for Infectious Disease Research, Heidelberg, Germany.",,,,,,"BACKGROUND: In 2015, Brazil was faced with the cocirculation of three arboviruses of major public health importance. The emergence of Zika virus (ZIKV) presents new challenges to both clinicians and public health authorities. Overlapping clinical features between diseases caused by ZIKV, Dengue (DENV) and Chikungunya (CHIKV) and the lack of validated serological assays for ZIKV make accurate diagnosis difficult. METHODOLOGY / PRINCIPAL FINDINGS: The outpatient service for acute febrile illnesses in Fiocruz initiated a syndromic clinical observational study in 2007 to capture unusual presentations of DENV infections. In January 2015, an increase of cases with exanthematic disease was observed. Trained physicians evaluated the patients using a detailed case report form that included clinical assessment and laboratory investigations. The laboratory diagnostic algorithm included assays for detection of ZIKV, CHIKV and DENV. 364 suspected cases of Zika virus disease were identified based on clinical criteria between January and July 2015. Of these, 262 (71.9%) were tested and 119 (45.4%) were confirmed by the detection of ZIKV RNA. All of the samples with sequence information available clustered within the Asian genotype. CONCLUSIONS / SIGNIFICANCE: This is the first report of a ZIKV outbreak in the state of Rio de Janeiro, based on a large number of suspected (n = 364) and laboratory confirmed cases (n = 119). We were able to demonstrate that ZIKV was circulating in Rio de Janeiro as early as January 2015. The peak of the outbreak was documented in May/June 2015. More than half of the patients reported headache, arthralgia, myalgia, non-purulent conjunctivitis, and lower back pain, consistent with the case definition of suspected ZIKV disease issued by the Pan American Health Organization (PAHO). However, fever, when present, was low-intensity and short-termed. In our opinion, pruritus, the second most common clinical sign presented by the confirmed cases, should be added to the PAHO case definition, while fever could be given less emphasis. The emergence of ZIKV as a new pathogen for Brazil in 2015 underscores the need for clinical vigilance and strong epidemiological and laboratory surveillance.",Pubmed,May 30, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Original research,No,Yes,803,Clinical/epidemiological research,Ecological study/outbreak report
804,"Rasmussen, N Engl J Med, 2016",Rasmussen,"Rasmussen, S. A.; Jamieson, D. J.; Honein, M. A.; Petersen, L. R.",Zika Virus and Birth Defects--Reviewing the Evidence for Causality,N Engl J Med,374,20,1981-7,2016,2010-present,April 14, 2016,27074377,10.1056/NEJMsr1604338,2504,English,http://www.ncbi.nlm.nih.gov/pubmed/27074377,"From the Division of Public Health Information Dissemination, Center for Surveillance, Epidemiology, and Laboratory Services (S.A.R.), Division of Reproductive Health, National Center for Chronic Disease Prevention and Health Promotion (D.J.J.), and Division of Congenital and Developmental Disorders, National Center on Birth Defects and Developmental Disabilities (M.A.H.), Centers for Disease Control and Prevention, Atlanta; and the Division of Vector-Borne Diseases, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, CO (L.R.P.).",,,,,Brazil/epidemiology; Causality; Humans; Microcephaly/*epidemiology/virology; *Zika Virus; Zika Virus Infection/*complications,The Zika virus has spread rapidly in the Americas since its first identification in Brazil in early 2015. Prenatal Zika virus infection has been linked to adverse anomalies. To determine whether Zika virus infection during pregnancy causes we conclude that a causal relationship exists between prenatal Zika virus infection and microcephaly and other serious brain anomalies. Evidence that was used to support this . . .,Pubmed,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Yes,Review,No,Yes,804,Clinical/epidemiological research,Epidemiological/clinical review
805,"Li, Emerg Infect Dis, 2016",Li,"Li, J.; Xiong, Y.; Wu, W.; Liu, X.; Qu, J.; Zhao, X.; Zhang, S.; Li, J.; Li, W.; Liao, Y.; Gong, T.; Wang, L.; Shi, Y.; Xiong, Y.; Ni, D.; Li, Q.; Liang, M.; Hu, G.; Li, D.","Zika Virus in a Traveler Returning to China from Caracas, Venezuela, February 2016",Emerg Infect Dis,22,6,1133-6,2016,2010-present,April 14, 2016,27070735,10.3201/eid2206.160273,2407,English,http://www.ncbi.nlm.nih.gov/pubmed/27070735,,,,,,Aedes; Aedes aegypti; Aedes albopictus; Caracas; China; Jiangxi; Venezuela; Zikav; Zika virus; flavivirus; mosquitoes; travel; vector-borne infections; viruses,,Pubmed,May 30, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Unknown/unclear,Original research,No,Yes,805,Clinical/epidemiological research,Case report
806,"Fellner, P T, 2016",Fellner,"Fellner, C.",Zika Virus: Anatomy of a Global Health Crisis,P T,41,4,242-53,2016,2010-present,April 14, 2016,27069344,,2392,English,http://www.ncbi.nlm.nih.gov/pubmed/27069344,,,,,,,"Zika virus infection has emerged as the world's newest health threat, linked to microcephaly in infants and Guillain-Barre syndrome in adults. We address the rapid global spread of this disease, and the prospects for successful prevention and treatment.",Pubmed,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,806,,
807,"WHO, , 2016",WHO,WHO,"Zika situation report. Zika virus, Microcephaly and Guillain-Barré syndrome - 14 April 2016",,,,,2016,2010-present,April 14, 2016,,,2732,,http://www.who.int/emergencies/zika-virus/situation-report/14-april-2016/en/,,Switzerland,Europe,,Public/Government,,,WHO,May 30, 2016,Yes,,No,"Zika, indirect evidence or other topic",Surveillance report or data,,,No,Yes,807,Clinical/epidemiological research,Ecological study/outbreak report
808,"Ogden, Sci China Life Sci, 2016",Ogden,"Ogden, S. C.; Hammack, C.; Tang, H.",Zika virus and neural developmental defects: building a case for a cause,Sci China Life Sci,59,5,536-8,2016,2010-present,April 14, 2016,27066795,10.1007/s11427-016-5053-2,2492,English,http://www.ncbi.nlm.nih.gov/pubmed/27066795,"Department of Biological Science, Florida State University, Tallahassee, FL32306, USA.; Department of Biological Science, Florida State University, Tallahassee, FL32306, USA. tang@bio.fsu.edu.",,,,,,,Pubmed,May 30, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,808,,
809,"Nourollahpour Shiadeh, J Matern Fetal Neonatal Med, 2016",Nourollahpour Shiadeh,"Nourollahpour Shiadeh, M.; Rostami, A.; Danesh, M.; Sajedi, A. A.",Zika virus as new emerging global health threat for pregnancy and child birth,J Matern Fetal Neonatal Med,,,1,2016,2010-present,April 14, 2016,27072040,10.1080/14767058.2016.1177820,2556,English,http://www.ncbi.nlm.nih.gov/pubmed/27072040,"a Department of Midwifery and Reproductive Health , Nursing and Midwifery School, Mazandaran University of Medical Sciences , Sari , Iran .; b Department of Parasitology and Mycology , School of Medicine, Shahid Beheshti University of Medical Sciences , Tehran , Iran , and.; c Department of Forensic Medicine and Toxicology , School of Medicine, Shahid Beheshti University of Medical Sciences , Tehran , Iran.",,,,,,,Pubmed,May 30, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,809,,
810,"Giovanetti, Infect Genet Evol, 2016",Giovanetti,"Giovanetti, M.; Faria, N. R.; Nunes, M. R.; de Vasconcelos, J. M.; Lourenco, J.; Rodrigues, S. G.; Vianez, J. L., Jr.; da Silva, S. P.; Lemos, P. S.; Tavares, F. N.; Martin, D. P.; do Rosario, M. S.; Siqueira, I. C.; Ciccozzi, M.; Pybus, O. G.; de Oliveira, T.; Alcantara, L. C. Junior","Zika virus complete genome from Salvador, Bahia, Brazil",Infect Genet Evol,41,,142-145,2016,2010-present,April 14, 2016,27071531,10.1016/j.meegid.2016.03.030,2456,English,http://www.ncbi.nlm.nih.gov/pubmed/27071531,"Fundacao Oswaldo Cruz, Salvador, Bahia, Brazil; University of Rome 'Tor Vergata', Italy. Electronic address: giovanetti.marta@gmail.com.; Department of Zoology, University of Oxford, UK.; Instituto Evandro Chagas, Para, Brazil.; Division of Computational Biology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.; Fundacao Oswaldo Cruz, Salvador, Bahia, Brazil; Hospital Santa Isabel, Salvador, Bahia, Brazil.; Fundacao Oswaldo Cruz, Salvador, Bahia, Brazil.; National Institute of Healthy, Rome, Italy.; Africa Center, University of KwaZulu-Natal, Durban, South Africa.",,,,,Full-length sequence; Phylogeny; Zika virus,,Pubmed,May 30, 2016,Yes,,No,"Zika, not relevant to causality framework",Scientific (journal) article,Unknown/unclear,Original research,No,Yes,810,Basic and applied biomedical research,Sequence analysis and phylogenetics
811,"Musso, Clin Microbiol Infect, 2016",Musso,"Musso, D.; Baud, D.; Gubler, D. J.",Zika virus: what do we know?,Clin Microbiol Infect,,,,2016,2010-present,April 14, 2016,27067096,10.1016/j.cmi.2016.03.032,2557,English,http://www.ncbi.nlm.nih.gov/pubmed/27067096,"Unit of Emerging Infectious Diseases, Institut Louis Malarde, Tahiti, French Polynesia. Electronic address: dmusso@ilm.pf.; Materno-fetal and Obstetrics Research Unit, Department 'Femme-Mere-Enfant', Maternity, University Hospital, Lausanne, Switzerland.; Program in Emerging Infectious Disease, Duke-NUS Medical School, Singapore.",,,,,Frech Polynesia; Guillain-Barresyndrome; Zikv; Zika virus; arbovirus; microcephaly,,Pubmed,May 30, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,811,,
812,"de Fatima Vasco Aragao, BMJ, 2016",de Fatima Vasco Aragao,"de Fatima Vasco Aragao, M.; van der Linden, V.; Brainer-Lima, A. M.; Coeli, R. R.; Rocha, M. A.; Sobral da Silva, P.; Durce Costa Gomes de Carvalho, M.; van der Linden, A.; Cesario de Holanda, A.; Valenca, M. M.",Clinical features and neuroimaging (CT and MRI) findings in presumed Zika virus related congenital infection and microcephaly: retrospective case series study,BMJ,353,,i1901,2016,2010-present,April 15, 2016,27075009,10.1136/bmj.i1901,2340,English,http://www.ncbi.nlm.nih.gov/pubmed/27075009,"Centro Diagnostico Multimagem, Rua Frei Matias Tevis, 194, Ilha do Leite Recife Pernambuco 52010-450, Brazil; Medical School, Mauricio de Nassau University, Recife, Pernambuco, Brazil fatima.vascoaragao@gmail.com.; Association for Assistance of Disabled Children, Recife, Brazil; Barao de Lucena Hospital, Recife, Brazil.; PROCAPE, University of Pernambuco, Recife, Brazil.; Oswaldo Cruz University Hospital, Recife, Brazil.; Prof Fernando Figueira Integral Medicine Institute, Recife, Brazil.; Medical School, Federal University of Pernambuco, Recife, Brazil.; Neurology and Neurosurgery, Federal University of Pernambuco, Recife, Brazil.",Brazil,Americas,Brazil,No funding received,,"OBJECTIVE: To report radiological findings observed in computed tomography (CT) and magnetic resonance imaging (MRI) scans of the first cases of congenital infection and microcephaly presumably associated with the Zika virus in the current Brazilian epidemic. DESIGN: Retrospective study with a case series. SETTING: Association for Assistance of Disabled Children (AACD), Pernambuco state, Brazil. PARTICIPANTS: 23 children with a diagnosis of congenital infection presumably associated with the Zika virus during the Brazilian microcephaly epidemic. MAIN OUTCOME MEASURES: Types of abnormalities and the radiological pattern of lesions identified on CT and MRI brain scans. RESULTS: Six of the 23 children tested positive for IgM antibodies to Zika virus in cerebrospinal fluid. The other 17 children met the protocol criteria for congenital infection presumably associated with the Zika virus, even without being tested for IgM antibodies to the virus-the test was not yet available on a routine basis. Of the 23 children, 15 underwent CT, seven underwent both CT and MRI, and one underwent MRI. Of the 22 children who underwent CT, all had calcifications in the junction between cortical and subcortical white matter, 21 (95%) had malformations of cortical development, 20 (91%) had a decreased brain volume, 19 (86%) had ventriculomegaly, and 11 (50%) had hypoplasia of the cerebellum or brainstem. Of the eight children who underwent MRI, all had calcifications in the junction between cortical and subcortical white matter, malformations of cortical development occurring predominantly in the frontal lobes, and ventriculomegaly. Seven of the eight (88%) children had enlarged cisterna magna, seven (88%) delayed myelination, and six each (75%) a moderate to severe decrease in brain volume, simplified gyral pattern, and abnormalities of the corpus callosum (38% hypogenesis and 38% hypoplasia). Malformations were symmetrical in 75% of the cases. CONCLUSION: Severe cerebral damage was found on imaging in most of the children in this case series with congenital infection presumably associated with the Zika virus. The features most commonly found were brain calcifications in the junction between cortical and subcortical white matter associated with malformations of cortical development, often with a simplified gyral pattern and predominance of pachygyria or polymicrogyria in the frontal lobes. Additional findings were enlarged cisterna magna, abnormalities of corpus callosum (hypoplasia or hypogenesis), ventriculomegaly, delayed myelination, and hypoplasia of the cerebellum and the brainstem.",Pubmed,May 30, 2016,Yes,,Yes,,Scientific (journal) article,Yes,Original research,Yes,No,758,Clinical/epidemiological research,Case series
813,"ECDC, , 2016",ECDC,ECDC,Epidemiological update. Outbreaks of Zika virus and complication potentially linked to the Zika virus infection - 15 April 2016,,,,,2016,2010-present,April 15, 2016,,,2199,,http://ecdc.europa.eu/en/press/news/_layouts/forms/News_DispForm.aspx?ID=1398&List=8db7286c-fe2d-476c-9133-18ff4cb1b568&Source=http%3A%2F%2Fecdc.europa.eu%2Fen%2Fhealthtopics%2Fzika_virus_infection%2FPages%2Fepidemiological-updates.aspx,,Sweden,Europe,,Public/Government,,,ECDC,May 30, 2016,Yes,,No,"Zika, indirect evidence or other topic",Surveillance report or data,,,No,Yes,813,Clinical/epidemiological research,Ecological study/outbreak report
814,"Deckard, MMWR Morb Mortal Wkly Rep, 2016",Deckard,"Deckard, D. T.; Chung, W. M.; Brooks, J. T.; Smith, J. C.; Woldai, S.; Hennessey, M.; Kwit, N.; Mead, P.","Male-to-Male Sexual Transmission of Zika Virus - Texas, January 2016",MMWR Morb Mortal Wkly Rep,65,14,372-4,2016,2010-present,April 15, 2016,27078057,10.15585/mmwr.mm6514a3,2281,English,http://www.ncbi.nlm.nih.gov/pubmed/27078057,,,,,,,"Zika virus infection has been linked to increased risk for Guillain-Barre syndrome and adverse fetal outcomes, including congenital microcephaly. In January 2016, after notification from a local health care provider, an investigation by Dallas County Health and Human Services (DCHHS) identified a case of sexual transmission of Zika virus between a man with recent travel to an area of active Zika virus transmission (patient A) and his nontraveling male partner (patient B). At this time, there had been one prior case report of sexual transmission of Zika virus (1). The present case report indicates Zika virus can be transmitted through anal sex, as well as vaginal sex. Identification and investigation of cases of sexual transmission of Zika virus in nonendemic areas present valuable opportunities to inform recommendations to prevent sexual transmission of Zika virus.",Pubmed,May 30, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,No,Original research,No,Yes,814,Clinical/epidemiological research,Case report
815,"Govindarajan, Parasitol Res, 2016",Govindarajan,"Govindarajan, M.; Hoti, S. L.; Rajeswary, M.; Benelli, G.",One-step synthesis of polydispersed silver nanocrystals using Malva sylvestris: an eco-friendly mosquito larvicide with negligible impact on non-target aquatic organisms,Parasitol Res,115,7,2685-95,2016,2010-present,April 15, 2016,27075309,10.1007/s00436-016-5038-x,2422,English,http://www.ncbi.nlm.nih.gov/pubmed/27075309,"Unit of Vector Control, Phytochemistry and Nanotechnology, Department of Zoology, Annamalai University, Annamalainagar, 608 002, Tamil Nadu, India. drgovindzoo@yahoo.com.; Regional Medical Research Centre, Nehru Nagar, Belgaum, 590010, Karnataka, India.; Unit of Vector Control, Phytochemistry and Nanotechnology, Department of Zoology, Annamalai University, Annamalainagar, 608 002, Tamil Nadu, India.; Department of Agriculture, Food and Environment, University of Pisa, via del Borghetto 80, 56124, Pisa, Italy. g.benelli@sssup.it.",,,,,Biosafety; Biosynthesis; Mosquito-borne diseases; Nanotechnology; Zika virus,"The synthesis of eco-friendly nanoparticles is evergreen branch of nanoscience with a growing number of biomedical implications. In this study, we investigated the synthesis of polydisperse and stable silver nanoparticles (AgNP) using a cheap leaf extract of Malva sylvestris (Malvaceae). Bio-reduced AgNP were characterized by UV-visible spectrophotometry, Fourier transform infrared spectroscopy (FTIR), X-ray diffraction analysis (XRD), atomic force microscopy (AFM), scanning electron microscopy (SEM) and transmission electron microscopy (TEM). The acute toxicity of M. sylvestris leaf extract and green-synthesized AgNP was evaluated against larvae of the malaria vector Anopheles stephensi, the dengue vector Aedes aegypti and the filariasis vector Culex quinquefasciatus. Compared to the leaf aqueous extract, AgNP showed higher toxicity against A. stephensi, A. aegypti, and C. quinquefasciatus with LC50 values of 10.33, 11.23, and 12.19 mug/mL, respectively. Green-synthesized AgNP were found safer to non-target organisms Diplonychus indicus and Gambusia affinis, with respective LC50 values ranging from 813.16 to 1044.52 mug/mL. Overall, this research firstly shed light on the mosquitocidal potential of M. sylvestris, a potential bio-resource for rapid, cheap and effective synthesis of polydisperse and highly stable silver nanocrystals.",Pubmed,May 30, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Original research,No,Yes,815,Environmental and vector research,Vector control studies
816,"InVS, Point Epidemiologique CIRE Antilles Guyane, 2016",InVS,InVS,Point epidemio: Emergence du virus zika aux Antilles Guyane : Situation epidemiologique - 15 avril 2016,Point Epidemiologique CIRE Antilles Guyane,14,,,2016,2010-present,April 15, 2016,,,2233,French,,,France,Europe,,Public/Government,,,Institute de veille sanitaire,May 30, 2016,Yes,,No,"Zika, indirect evidence or other topic",Surveillance report or data,,,No,Yes,816,Clinical/epidemiological research,Ecological study/outbreak report
817,"Higgs, Trans R Soc Trop Med Hyg, 2016",Higgs,"Higgs, S.; Vanlandingham, D. L.",Search and one will find: Zika virus everywhere,Trans R Soc Trop Med Hyg,110,4,207-8,2016,2010-present,April 15, 2016,27076507,10.1093/trstmh/trw020,2425,English,http://www.ncbi.nlm.nih.gov/pubmed/27076507,"Biosecurity Research Institute and Department of Diagnostic Medicine and Pathobiology, Kansas State University, Manhattan, Kansas, USA shiggs@ksu.edu.; Biosecurity Research Institute and Department of Diagnostic Medicine and Pathobiology, Kansas State University, Manhattan, Kansas, USA.",,,,,Aedes aegypti; Epidemic; Microcephaly; Transmission; Zika virus,,Pubmed,May 30, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,817,,
818,"Vasquez, MMWR Morb Mortal Wkly Rep, 2016",Vasquez,"Vasquez, A. M.; Sapiano, M. R.; Basavaraju, S. V.; Kuehnert, M. J.; Rivera-Garcia, B.","Survey of Blood Collection Centers and Implementation of Guidance for Prevention of Transfusion-Transmitted Zika Virus Infection - Puerto Rico, 2016",MMWR Morb Mortal Wkly Rep,65,14,375-8,2016,2010-present,April 15, 2016,27078190,10.15585/mmwr.mm6514e1,2514,English,http://www.ncbi.nlm.nih.gov/pubmed/27078190,,,,,,,"Since November 2015, Puerto Rico has reported active mosquito-borne transmission of Zika virus (1). Because of the potential for Zika virus to be transmitted through transfusion of blood components, and because a high percentage of persons infected with Zika virus are asymptomatic (2), the Food and Drug Administration (FDA) recommended that blood collections cease in areas of the United States affected by active vector-borne transmission of Zika virus until laboratory screening of blood donations or pathogen reduction technology (PRT)* for treatment of blood components can be implemented (3). To inform efforts to maintain the safety and availability of the blood supply in Puerto Rico, CDC, in collaboration with the Puerto Rico Department of Health, conducted a rapid assessment of blood collection and use on the island. A total of 139,369 allogeneic red blood cell (RBC) units,(dagger) 45,243 platelet units, and 56,466 plasma units were collected in or imported to Puerto Rico during 2015, and 135,966 allogeneic RBC units, 13,526 therapeutic platelet units,( section sign) and 25,775 plasma units were transfused. Because of the potential for local Zika virus transmission in areas with a competent mosquito vector (4), other areas of the United States should develop plans to ensure local blood safety and adequacy. Blood collection organizations and public health agencies should collaborate to maintain the safety and availability of local blood supplies in accordance with FDA guidance.",Pubmed,May 30, 2016,Yes,,No,"Zika, not relevant to causality framework",Scientific (journal) article,No,Original research,No,Yes,818,Clinical/epidemiological research,Qualitative study
819,"Maestre, EBioMedicine, 2016",Maestre,"Maestre, A. M.; Caplivski, D.; Fernandez-Sesma, A.",Zika Virus: More Questions Than Answers,EBioMedicine,5,,02. Mrz,2016,2010-present,April 15, 2016,27077095,10.1016/j.ebiom.2016.03.014,2423,English,http://www.ncbi.nlm.nih.gov/pubmed/27077095,"Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, United States.; Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, United States.; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, United States; Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, United States.",,,,,,,Pubmed,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,819,,
820,"Check Hayden, Nature, 2016",Check Hayden,"Check Hayden, E.",Zika highlights role of controversial fetal-tissue research,Nature,532,7597,16,2016,2010-present,April 15, 2016,27078543,10.1038/nature.2016.19655,2346,English,http://www.ncbi.nlm.nih.gov/pubmed/27078543,,,,,,Brain/abnormalities/cytology/metabolism/virology; Female; *Fetal Research/economics/legislation & jurisprudence; Fetus/*abnormalities/*virology; Humans; Microcephaly/*etiology/*virology; Neural Stem Cells/metabolism/virology; Organoids/metabolism/virology; Placenta/cytology/metabolism/virology; Pregnancy; Proto-Oncogene Proteins/metabolism; Receptor Protein-Tyrosine Kinases/metabolism; Tissue and Organ Procurement; Trophoblasts/metabolism/virology; Zika Virus/*pathogenicity; Zika Virus Infection/*complications/congenital/virology,,Pubmed,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,News item or lay press,,,No,Yes,820,,
821,"Baggoley, Med J Aust, 2016",Baggoley,"Baggoley, C.; Knope, K.; Colwell, A.; Firman, J.",Zika preparedness in Australia,Med J Aust,204,7,249-50,2016,2010-present,April 15, 2016,27078587,,2343,English,http://www.ncbi.nlm.nih.gov/pubmed/27078587,"Australian Government Department of Health, Canberra, ACT chris.baggoley@health.gov.au.; Australian Government Department of Health, Canberra, ACT.",,,,,,,Pubmed,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,821,,
822,"Cavalheiro, Childs Nerv Syst, 2016",Cavalheiro,"Cavalheiro, S.; Lopez, A.; Serra, S.; Da Cunha, A.; da Costa, M. D.; Moron, A.; Lederman, H. M.",Microcephaly and Zika virus: neonatal neuroradiological aspects,Childs Nerv Syst,32,6,1057-60,2016,2010-present,April 16, 2016,27080092,10.1007/s00381-016-3074-6,2293,English,http://www.ncbi.nlm.nih.gov/pubmed/27080092,"Department of Neurosurgery, Federal University of Sao Paulo, Rua Botucatu, 591, conj 41, Sao Paulo, SP, 04023-062, Brazil. sergiocavalheironeuro@gmail.com.; Neurosurgery Service of Hospital da Restauracao, Recife, Pernambuco, Brazil.; Department of Neurosurgery, Federal University of Sao Paulo, Rua Botucatu, 591, conj 41, Sao Paulo, SP, 04023-062, Brazil.; Department of Obstetrics, Federal University of Sao Paulo, Sao Paulo, SP, Brazil.; Department of Diagnostic Imaging, Federal University of Sao Paulo, Sao Paulo, SP, Brazil.",Brazil,Americas,Brazil,Not reported/unknown,Aedes aegypti; Intracranial calcifications; Lissencephaly; Microcephaly; Ventriculomegaly; Zika virus,"PURPOSE: The aim of this study is to describe some radiological features in the newborns with microcephaly caused by Zika virus infection during pregnancy. METHODS: We radiologically analyzed 13 cases of newborns with microcephaly born to mothers who were infected by the Zika virus in the early stage of pregnancy. RESULTS: The most frequently observed radiological findings were microcephaly and decreased brain parenchymal volume associated with lissencephaly, ventriculomegaly secondary to the lack of brain tissue (not hypertensive), and coarse and anarchic calcifications mainly involving the subcortical cortical transition, and the basal ganglia. CONCLUSIONS: Although it cannot be concluded that there is a definitive pathognomonic radiographic pattern of microcephaly caused by Zika virus, gross calcifications and anarchic distribution involving the subcortical cortical transition and the basal ganglia, in association with lissencephaly and in the absence of hypertensive ventriculomegaly, are characteristic of this type of infection.",Pubmed,May 30, 2016,Yes,,Yes,,Scientific (journal) article,Yes,Original research,Yes,No,758,Clinical/epidemiological research,Case series
823,"Maron, Sci Am, 2016",Maron,"Maron, D. F.",Travels with Zika,Sci Am,314,4,84,2016,2010-present,April 16, 2016,27082204,10.1038/scientificamerican0416-84,2410,English,http://www.ncbi.nlm.nih.gov/pubmed/27082204,,,,,,Aedes; Animals; Humans; Insect Vectors; Sexually Transmitted Diseases/epidemiology/virology; Travel; United States/epidemiology; Zika Virus; Zika Virus Infection/*epidemiology/*transmission,,Pubmed,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,News item or lay press,,,No,Yes,823,,
824,"Hillebrandt, High Alt Med Biol, 2016",Hillebrandt,"Hillebrandt, D.; Richards, P.; Clark, A.; Jean, D.",Zika Virus Advice for Mountaineers: A UIAA Medcom Consensus Advice Sheet,High Alt Med Biol,17,2,70-1,2016,2010-present,April 16, 2016,27081746,10.1089/ham.2016.0013,2397,English,http://www.ncbi.nlm.nih.gov/pubmed/27081746,"1 Derriton House , Holsworthy, United Kingdom .; 2 UIAA Medical Commission , UIAA, Bern, Switzerland .; 3 South Essex Travel Clinic , Billericay, Essex, United Kingdom .; 4 Durham, Durham, United Kingdom .; 5 Centre Hospitalier Universitaire de Grenoble , Centre Pluridisciplinaire de Diagnostic Prenatal, Grenoble, France .",,,,,Zika virus; mountain travel; travel advice,"With the current media coverage of the spread of Zika virus from Africa and Asia to Central and South America and its possible relationship with fetal abnormalities, UIAA Medcom has produced an advice sheet for mountaineers visiting risk areas.",Pubmed,May 30, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Unknown/unclear,Original research,No,Yes,824,Clinical/epidemiological research,Guidelines
825,"Picone, J Gynecol Obstet Biol Reprod (Paris), 2016",Picone,"Picone, O.; Vauloup-Fellous, C.; D'Ortenzio, E.; Huissoud, C.; Carles, G.; Benachi, A.; Faye, A.; Luton, D.; Paty, M. C.; Ayoubi, J. M.; Yazdanpanah, Y.; Mandelbrot, L.; Matheron, S.",[Zika virus infection during pregnancy],J Gynecol Obstet Biol Reprod (Paris),45,5,415-23,2016,2010-present,April 16, 2016,27079865,10.1016/j.jgyn.2016.03.005,2523,French,http://www.ncbi.nlm.nih.gov/pubmed/27079865,"Department of obstetrics and gynecology, hopital Foch, 40, rue Worth, 92151 Suresnes, France; EA2493, UFR des sciences de la sante Simone-Veil, universite Versailles Saint-Quentin-en-Yvelines, 78180 Montigny-le-Bretonneux, France. Electronic address: o.picone@hopital-foch.org.; Inserm U1193, National reference laboratory for maternofetal rubella infections, service de virologie, hopital Paul-Brousse, WHO Rubella NRL, universite Paris-Sud, groupe hospitalier universitaire Paris-Sud, AP-HP, 94804 Villejuif, France.; Service des maladies infectieuses et tropicales, AP-HP, Hopital Bichat, HPNVS, Paris 7-Denis Diderot University, Paris, France; Inserm, infections, antimicrobiens, modelisation, evolution (IAME), UMR 1137, Paris 7-Denis Diderot University, 75018 Paris, France.; Service de gynecologie-obstetrique, hopital de la Croix-Rousse, hospices civils de Lyon, 103, Grande-Rue-de-la-Croix-Rousse, 69317 Lyon cedex 04, France; Universite Claude-Bernard Lyon 1, UER Lyon-Est, 8, avenue Rockefeller, 69008 Lyon, France; Inserm U846, Stem cell and brain research institute, 18, avenue Doyen-Lepine, 69500 Bron, France; UMR-S 846, universite de Lyon, Lyon 1, 69003 Lyon, France.; Centre hospitalier de l'Ouest guyanais, Saint-Laurent-du-Maroni, Guyane francaise.; Department of obstetrics, gynecology and reproductive medicine, centre maladies rares, hernie de coupole diaphragmatique, hopital Antoine-Beclere, universite Paris Sud, AP-HP, 92140 Clamart, France.; Service de pediatrie generale et maladies infectieuses, hopital Robert-Debre, Assistance publique-Hopitaux de Paris, 48, boulevard Serrurier, 75019 Paris, France; Inserm 1123, universite Paris 7 Denis Diderot, Sorbonne Paris Cite, Paris, France.; Department of gynecology, obstetrics and reproduction, Bichat-Claude-Bernard hospital, Assistance publique-Hopitaux de Paris, 46, rue Henri-Huchard, 75018 Paris, France; DHU risque et grossesse, Paris 7-Denis Diderot university, Paris, France.; Coordination de la surveillance des maladies vectorielles, departement des maladies infectieuses, institut de veille sanitaire, 94415 Saint-Maurice, France.; Department of obstetrics and gynecology, hopital Foch, 40, rue Worth, 92151 Suresnes, France; EA2493, UFR des sciences de la sante Simone-Veil, universite Versailles Saint-Quentin-en-Yvelines, 78180 Montigny-le-Bretonneux, France.; Service des maladies infectieuses et tropicales, hopital Bichat, HPNVS, AP-HP, 46, rue Henri-Huchard, 75018 Paris, France; Inserm, infections, antimicrobiens, modelisation, evolution (IAME), UMR 1137, universite Paris Diderot, Sorbonne Paris Cite, Paris, France.; Risk in pregnancy university department, Paris, France; Service de gynecologie et obstetrique, hopital Louis-Mourier, Assistance publique-Hopitaux de Paris, 178, rue des Renouillets, 92700 Colombes, France; Universite Paris-Diderot, Paris, France; Inserm CESP, 1019 Kremlin-Bicetre, France.",,,,,Congenital infection; Infection congenitale; Microcephaly; Microcephalie; Prevention; Virus Zika; Zika virus,"A Zika virus epidemic is currently ongoing in the Americas. This virus is linked to congenital infections with potential severe neurodevelopmental dysfunction. However, incidence of fetal infection and whether this virus is responsible of other fetal complications are still unknown. National and international public health authorities recommend caution and several prevention measures. Declaration of Zika virus infection is now mandatory in France. Given the available knowledge on Zika virus, we suggest here a review of the current recommendations for management of pregnancy in case of suspicious or infection by Zika virus in a pregnant woman.",Pubmed,May 30, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Unknown/unclear,Review,No,Yes,825,Clinical/epidemiological research,Epidemiological/clinical review
826,"Baptista, BMJ, 2016",Baptista,"Baptista, T.; Quaghebeur, G.; Alarcon, A.",Neuroimaging findings of babies with microcephaly and presumed congenital Zika virus infection,BMJ,353,,i2194,2016,2010-present,April 17, 2016,27083981,10.1136/bmj.i2194,2317,English,http://www.ncbi.nlm.nih.gov/pubmed/27083981,"Department of Neuroradiology, Oxford University Hospitals NHS Foundation Trust, Oxford OX3 9DU, UK.; Neonatal Unit, Oxford University Hospitals NHS Foundation Trust.",,,,,,,Pubmed,May 30, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,826,,
827,"Dyer, BMJ, 2016",Dyer,"Dyer, O.",US agency says Zika virus causes microcephaly,BMJ,353,,i2167,2016,2010-present,April 17, 2016,27083694,10.1136/bmj.i2167,2447,English,http://www.ncbi.nlm.nih.gov/pubmed/27083694,Montreal.,,,,,,,Pubmed,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,News item or lay press,,,No,Yes,827,,
828,"Diaz-Quinonez, Emerg Infect Dis, 2016",Diaz-Quinonez,"Diaz-Quinonez, J. A.; Escobar-Escamilla, N.; Wong-Arambula, C.; Vazquez-Pichardo, M.; Torres-Longoria, B.; Lopez-Martinez, I.; Ruiz-Matus, C.; Kuri-Morales, P.; Ramirez-Gonzalez, J. E.","Asian Genotype Zika Virus Detected in Traveler Returning to Mexico from Colombia, October 2015",Emerg Infect Dis,22,5,937-9,2016,2010-present,April 19, 2016,27088574,10.3201/eid2205.160190,2345,English,http://www.ncbi.nlm.nih.gov/pubmed/27088574,,,,,,Asian genotype; Colombia; Mexico; Zika virus; travel; viruses,,Pubmed,May 30, 2016,Yes,,No,"Zika, not relevant to causality framework",Scientific (journal) article,Unknown/unclear,Original research,No,Yes,828,Basic and applied biomedical research,Sequence analysis and phylogenetics
829,"Corman, Bull World Health Organ, 2016",Corman,"Corman, Victor M.; Rasche, Andrea; Baronti, Cecile; Aldabbagh, Souhaib; Cadar, Daniel; Reusken, Chantal B. E. M.; Pas, Suzan D.; Goorhuis, Abraham; Schinkel, Janke; Molenkamp, Richard; Kuemmerer, Beate M.; Bleicker, Tobias; Brünink, Sebastian; Eschbach-Bludau, Monika; Eis-Hübinger, Anna M.; Koopmans, Marion P.; Schmidt-Chanasit, Jonas; Grobusch, Martin P.; de Lamballerie, Xavier; Drosten, Christian; Drexler, Jan Felix","Clinical comparison, standardization and optimization of Zika virus molecular detection",Bull World Health Organ,published online: 19.04.2016 (submitted 18.04.2016),,,2016,2010-present,April 19, 2016,,10.2471/blt.16.175950,2721,,http://www.who.int/bulletin/online_first/16-175950.pdf,,,,,,,,WHO Zika open,May 30, 2016,Yes,,No,"Zika, not relevant to causality framework",Scientific (journal) article,No,Original research,No,Yes,829,Clinical/epidemiological research,Diagnostic study
830,"Atkinson, Emerg Infect Dis, 2016",Atkinson,"Atkinson, B.; Hearn, P.; Afrough, B.; Lumley, S.; Carter, D.; Aarons, E. J.; Simpson, A. J.; Brooks, T. J.; Hewson, R.",Detection of Zika Virus in Semen,Emerg Infect Dis,22,5,940,2016,2010-present,April 19, 2016,27088817,10.3201/eid2205.160107,2365,English,http://www.ncbi.nlm.nih.gov/pubmed/27088817,,,,,,Zika; diagnostic; flaviviruses; semen; sexual transmission; viruses,,Pubmed,May 30, 2016,Yes,,No,"Zika, not relevant to causality framework",Scientific (journal) article,Unknown/unclear,Original research,No,Yes,830,Clinical/epidemiological research,Case report
831,"Perkasa, Emerg Infect Dis, 2016",Perkasa,"Perkasa, A.; Yudhaputri, F.; Haryanto, S.; Hayati, R. F.; Ma'roef, C. N.; Antonjaya, U.; Yohan, B.; Myint, K. S.; Ledermann, J. P.; Rosenberg, R.; Powers, A. M.; Sasmono, R. T.","Isolation of Zika Virus from Febrile Patient, Indonesia",Emerg Infect Dis,22,5,924-5,2016,2010-present,April 19, 2016,27088970,10.3201/eid2205.151915,2545,English,http://www.ncbi.nlm.nih.gov/pubmed/27088970,,,,,,Indonesia; Zika virus; arbovirus; vector-borne infections; viruses,,Pubmed,May 30, 2016,No,Duplicate of existing record,,,,,,,,,,
832,"Al-Tawfiq, Ann Am Thorac Soc, 2016",Al-Tawfiq,"Al-Tawfiq, J. A.; Gautret, P.; Benkouiten, S.; Memish, Z. A.",Mass Gatherings and the Spread of Respiratory Infections. Lessons from the Hajj,Ann Am Thorac Soc,13,6,759-65,2016,2010-present,April 19, 2016,27088298,10.1513/AnnalsATS.201511-772FR,2348,English,http://www.ncbi.nlm.nih.gov/pubmed/27088298,"1 Johns Hopkins Aramco Healthcare, Dhahran, Saudi Arabia.; 2 Indiana University School of Medicine, Indianapolis, Indiana.; 3 Aix Marseille Universite, Unite de Recherche sur les Maladies Infectieuses et Tropicales Emergentes, UM63, CNRS 7278, IRD 198, Inserm 1095, Marseille, France.; 4 Institut Hospitalo-Universitaire Mediterranee Infection, 13005 Marseille, France.; 5 College of Medicine, Alfaisal University, Riyadh, Saudi Arabia; and.; 6 Ministry of Health, Riyadh, Saudi Arabia.",,,,,Hajj; mass gathering; pilgrimage; respiratory infections,"The mass gathering of people is a potential source for developing, propagating, and disseminating infectious diseases on a global scale. Of the illnesses associated with mass gatherings, respiratory tract infections are the most common, the most easily transmitted, and the most likely to be spread widely beyond the site of the meeting by attendees returning home. Many factors contribute to the spread of these infections during mass gatherings, including crowding, the health of the attendees, and the type and location of meetings. The annual Hajj in the Kingdom of Saudi Arabia is the largest recurring single mass gathering in the world. Every year more than 10 million pilgrims attend the annual Hajj and Umrah. Attendees assemble in confined areas for several days. People with a wide range of age, health, susceptibility to illness, and hygiene sophistication come in close contact, creating an enormous public health challenge. Controlling respiratory infections at the Hajj requires surveillance, rapid diagnostic testing, and containment strategies. Although the Hajj is without equal, other mass gatherings can generate similar hazards. The geographic colocalization of the Zika virus epidemic and the 2016 Summer Olympic Games in Brazil is a current example of great concern. The potential of international mass gatherings for local and global calamity calls for greater global attention and research.",Pubmed,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,832,,
833,"Cao-Lormeau, Emerg Infect Dis, 2016",Cao-Lormeau,"Cao-Lormeau, V. M.",Tropical Islands as New Hubs for Emerging Arboviruses,Emerg Infect Dis,22,5,913-5,2016,2010-present,April 19, 2016,27088243,10.3201/eid2205.150547,2351,English,http://www.ncbi.nlm.nih.gov/pubmed/27088243,,,,,,Caribbean; Indian Ocean; Pacific; Zika; arboviruses; chikungunya; dengue; islands; tropical; vector-borne infections; viruses,,Pubmed,May 30, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,833,,
834,"Song, Nat Struct Mol Biol, 2016",Song,"Song, H.; Qi, J.; Haywood, J.; Shi, Y.; Gao, G. F.",Zika virus NS1 structure reveals diversity of electrostatic surfaces among flaviviruses,Nat Struct Mol Biol,23,5,456-8,2016,2010-present,April 19, 2016,27088990,10.1038/nsmb.3213,2529,English,http://www.ncbi.nlm.nih.gov/pubmed/27088990,"CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.; Research Network of Immunity and Health (RNIH), Beijing Institutes of Life Science, Chinese Academy of Sciences, Beijing, China.; Shenzhen Key Laboratory of Pathogen and Immunity, Shenzhen Third People's Hospital, Shenzhen, China.; Center for Influenza Research and Early-warning (CASCIRE), Chinese Academy of Sciences, Beijing, China.; Savaid Medical School, University of Chinese Academy of Sciences, Beijing, China.; National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention (China CDC), Beijing, China.",,,,,,"The association of Zika virus (ZIKV) infections with microcephaly has resulted in an ongoing public-health emergency. Here we report the crystal structure of a C-terminal fragment of ZIKV nonstructural protein 1 (NS1), a major host-interaction molecule that functions in flaviviral replication, pathogenesis and immune evasion. Comparison with West Nile and dengue virus NS1 structures reveals conserved features but diverse electrostatic characteristics at host-interaction interfaces, thus possibly implying different modes of flavivirus pathogenesis.",Pubmed,May 30, 2016,Yes,,No,"Zika, not relevant to causality framework",Scientific (journal) article,Yes,Original research,No,Yes,834,Basic and applied biomedical research,Biochemical/protein structure studies
835,"Lu, Zhonghua Liu Xing Bing Xue Za Zhi, 2016",Lu,"Lu, G. Y.; Su, Y. Y.; Wang, N.",[Several issues on the epidemiology of Zika virus disease],Zhonghua Liu Xing Bing Xue Za Zhi,37,4,450-4,2016,2010-present,April 19, 2016,27087204,10.3760/cma.j.issn.0254-6450.2016.04.002,2401,Other,http://www.ncbi.nlm.nih.gov/pubmed/27087204,"Department of Intensive Medicine, The First Affiliated Hospital of Xiamen University, Xiamen 361003, China.; The State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health, Xiamen University, Xiamen 361102, China.; National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.",,,,,,"Zika virus belongs to Aedes mosquito-borne flavivirus. In response to the current cluster of congenital malformations (microcephaly) and other neurological complications (Guillain-Barre Syndrome) that could be linked to Zika virus infection, WHO declares that Zika virus is of global public health importance. Data sources were from peer review articles and WHO documents. The sources of Zika virus infection would include patients, people with asymptomatic infections and primates. The infectious period of Zika virus remains unclear. However, according to the period that RNA of Zika virus can be positively detected in blood, saliva, urine or semen, we can presume that the communicable period may last for 2 months or even longer. Zika virus is primarily transmitted to humans by infected Aedes spp. mosquitoes. Presumptive vertical, blood or sexual routes of transmission have been reported. More evidence indicated the existence of a cause-effect relationship between Zika virus infection and congenital microcephaly/Guillain-Barre syndrome. Strategies include successful control the amount of mosquitoes and minimize the contacts between mosquitoes and human beings could effectively prevent the Zika virus transmission. Other preventive measures as cutting off vertical, blood or sexual routes of transmission should also be adopted. The epidemiology of Zika virus remains uncertain which calls for further research.",Pubmed,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,835,,
836,"Plusa, Pol Merkur Lekarski, 2016",Plusa,"Plusa, T.",[Zika virus as a new threat to the health and life],Pol Merkur Lekarski,40,237,149-52,2016,2010-present,April 19, 2016,27088194,,2478,Other,http://www.ncbi.nlm.nih.gov/pubmed/27088194,"EMC Medical Institute SA - Department of Internal Medicine and Lung Disease, Hospital st. Anna in Piaseczno, Poland.",,,,,Guillain-Barre Syndrome/virology; Humans; Somatoform Disorders/virology; *Zika Virus; Zika Virus Infection/*complications/diagnosis/epidemiology/transmission; Guillain-Barre; Zika virus; microcephaly,"The newly emerging pathogens are increasingly becoming a threat to health and life, as the cause of epidemic infections. In the last three years there were outbreaks caused by Zika virus, which was transmitted by mosquitoes mainly from the region of South America. However, reports WHO and CDC indicate that infection has now reached to most countries of the world, including European countries. The clinical picture of what is observed during the infection is not very distinctive, because apart from febrile states, and pain syndrome, including retrobulbar pain syndrome in the acute phase there are no other symptoms. The problem is especially severe neurological complications in the form of Guillain-Barre syndrome and other neurological disorders, as well as microcephaly had been found in newborns of mothers infected with the virus Zika. Treatment of infected patients boils down to symptomatic, because there is no vaccine or drugs to inhibit the replication of the virus. Underway while work on genetically modified mosquitoes to their offspring quickly wasting away. As part of the preventive measures recommended to bypass areas where the density of mosquitoes is particularly dangerous.",Pubmed,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,836,,
837,"Tavares, Contraception, 2016",Tavares,"Tavares, M. P.; Foster, A. M.",Emergency contraception in a public health emergency: exploring pharmacy availability in Brazil,Contraception,,,,2016,2010-present,April 20, 2016,27091724,10.1016/j.contraception.2016.04.006,2521,English,http://www.ncbi.nlm.nih.gov/pubmed/27091724,"Faculty of Health Sciences, University of Ottawa, Ottawa, ON, Canada.; Faculty of Health Sciences, University of Ottawa, Ottawa, ON, Canada; Institute of Population Health, University of Ottawa, Ottawa, ON, Canada. Electronic address: angel.foster@uottawa.ca.",,,,,Ec; ECPs; Latin America; Postcoital contraception; Zika virus,"INTRODUCTION: Dedicated progestin-only emergency contraceptive pills (ECPs) have been available with a prescription in Brazil since 1999. However, utilization of emergency contraception has been limited. We conducted a mystery client study at retail pharmacies in three regions to assess current availability. METHODS: Using a predetermined client profile, we approached a random sample of chain and independent pharmacies in urban areas in the southeastern, northeastern and central-west regions. We documented product availability, price and the client-pharmacy representative interaction at each site. We analyzed these data with descriptive statistics and for content and themes. RESULTS: We visited 122 pharmacies in early 2016. All but three pharmacies (97.5%) had ECPs in stock at the time of the interaction and offered our client the medication without a prescription. In general, pharmacy representatives did not ask questions or provide our client with information about emergency contraception. When prompted, over one third of the pharmacy representatives (37.7%) inaccurately reported that levonorgestrel ECPs could only be used immediately or within 12, 24 or 48h from the time of intercourse. CONCLUSION: Despite the current regulatory status, our findings suggest that progestin-only ECPs are widely available without a prescription. Additional efforts to ensure that women have up-to-date and medically accurate information about progestin-only ECPs appear warranted. Our findings suggest that more work needs to be done to align national regulatory policies with international standards and evidence-based practices. IMPLICATIONS: The Zika virus epidemic has shined a spotlight on the importance of providing timely access to emergency contraception in Latin America. This public health emergency offers a window of opportunity to advance national policies and practices to ensure that Brazilian women have access to a full range of reproductive health services.",Pubmed,May 30, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Unknown/unclear,Original research,No,Yes,837,Clinical/epidemiological research,Qualitative study
838,"Wang, Cell Host Microbe, 2016",Wang,"Wang, L.; Valderramos, S. G.; Wu, A.; Ouyang, S.; Li, C.; Brasil, P.; Bonaldo, M.; Coates, T.; Nielsen-Saines, K.; Jiang, T.; Aliyari, R.; Cheng, G.",From Mosquitos to Humans: Genetic Evolution of Zika Virus,Cell Host Microbe,19,5,561-5,2016,2010-present,April 20, 2016,27091703,10.1016/j.chom.2016.04.006,2501,English,http://www.ncbi.nlm.nih.gov/pubmed/27091703,"Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA; Center for Systems Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100005, China; Suzhou Institute of Systems Medicine, Suzhou, Jiangsu 215123, China.; Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Obstetrics & Gynecology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.; Center for Systems Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100005, China; Suzhou Institute of Systems Medicine, Suzhou, Jiangsu 215123, China.; Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA; Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.; Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA.; Instituto Nacional de Infectologia Evandro Chagas, Instituto Oswaldo Cruz - FIOCRUZ, Rio de Janeiro, CEP 21040-900, Brasil.; Laboratorio Biologia Molecular de Flavivirus, Instituto Oswaldo Cruz - FIOCRUZ, Rio de Janeiro, CEP 21040-900, Brasil.; UCLA Center for World Health, University of California, Los Angeles, Los Angeles, CA 90024, USA.; Division of Pediatric Infectious Diseases, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.; Center for Systems Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100005, China; Suzhou Institute of Systems Medicine, Suzhou, Jiangsu 215123, China. Electronic address: jtj@ism.cams.cn.; Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address: aliyarirs@ucla.edu.; Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA; Center for Systems Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100005, China; Suzhou Institute of Systems Medicine, Suzhou, Jiangsu 215123, China. Electronic address: gcheng@mednet.ucla.edu.",United States,Americas,United States,,,"Initially isolated in 1947, Zika virus (ZIKV) has recently emerged as a significant public health concern. Sequence analysis of all 41 known ZIKV RNA open reading frames to date indicates that ZIKV has undergone significant changes in both protein and nucleotide sequences during the past half century.",Pubmed,May 30, 2016,Yes,,No,"Zika, indirect evidence or other topic",Scientific (journal) article,Unknown/unclear,Original research,No,Yes,838,Basic and applied biomedical research,Sequence analysis and phylogenetics
839,"Lorenzetti, Fortune, 2016",Lorenzetti,"Lorenzetti, L.",How to Stop Zika,Fortune,173,3,18,2016,2010-present,April 20, 2016,27089762,,2459,English,http://www.ncbi.nlm.nih.gov/pubmed/27089762,,,,,,Disease Eradication; Humans; Reproductive Behavior; Vaccines; Zika Virus/drug effects; Zika Virus Infection/*prevention & control,,Pubmed,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,839,,
840,"Messina, Elife, 2016",Messina,"Messina, J. P.; Kraemer, M. U.; Brady, O. J.; Pigott, D. M.; Shearer, F. M.; Weiss, D. J.; Golding, N.; Ruktanonchai, C. W.; Gething, P. W.; Cohn, E.; Brownstein, J. S.; Khan, K.; Tatem, A. J.; Jaenisch, T.; Murray, C. J.; Marinho, F.; Scott, T. W.; Hay, S. I.",Mapping global environmental suitability for Zika virus,Elife,5,,,2016,2010-present,April 20, 2016,27090089,10.7554/eLife.15272,2490,English,http://www.ncbi.nlm.nih.gov/pubmed/27090089,"Department of Zoology, University of Oxford, Oxford, United Kingdom.; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.; Institute for Health Metrics and Evaluation, University of Washington, Seattle, United States.; Department of BioSciences, University of Melbourne, Parkville, United Kingdom.; WorldPop project, Department of Geography and Environment, University of Southampton, Southampton, United Kingdom.; Boston Children's Hospital, Harvard Medical School, Boston, United Kingdom.; Department of Medicine, Division of Infectious Diseases, University of Toronto, Toronto, Canada.; Li Ka Shing Knowledge Institute, St Michael's Hospital, Toronto, Canada.; Flowminder Foundation, Stockholm, Sweden.; Section Clinical Tropical Medicine, Department for Infectious Diseases, Heidelberg University Hospital, Heidelberg, Germany.; German Centre for Infection Research (DZIF), Heidelberg partner site, Heidelberg, Germany.; Secretariat of Health Surveillance, Ministry of Health Brazil, Brasilia, Brazil.; Department of Entomology and Nematology, University of California Davis, Davis, United States.",,,,,Zika virus; disease mapping; epidemiology; global health; human; infectious disease; microbiology; vector-borne disease; virus,"Zika virus was discovered in Uganda in 1947 and is transmitted by Aedes mosquitoes, which also act as vectors for dengue and chikungunya viruses throughout much of the tropical world. In 2007, an outbreak in the Federated States of Micronesia sparked public health concern. In 2013, the virus began to spread across other parts of Oceania and in 2015, a large outbreak in Latin America began in Brazil. Possible associations with microcephaly and Guillain-Barre syndrome observed in this outbreak have raised concerns about continued global spread of Zika virus, prompting its declaration as a Public Health Emergency of International Concern by the World Health Organization. We conducted species distribution modelling to map environmental suitability for Zika. We show a large portion of tropical and sub-tropical regions globally have suitable environmental conditions with over 2.17 billion people inhabiting these areas.",Pubmed,May 30, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Original research,No,Yes,840,Environmental and vector research,Ecological/vector modelling
841,"Guillemette-Artur, Pediatr Radiol, 2016",Guillemette-Artur,"Guillemette-Artur, P.; Besnard, M.; Eyrolle-Guignot, D.; Jouannic, J. M.; Garel, C.",Prenatal brain MRI of fetuses with Zika virus infection,Pediatr Radiol,46,7,1032-9,2016,2010-present,April 20, 2016,27090801,10.1007/s00247-016-3619-6,2442,English,http://www.ncbi.nlm.nih.gov/pubmed/27090801,"Service de Radiologie, Centre Hospitalier de Polynesie Francaise, Pirae, Tahiti, French Polynesia.; Service de Reanimation Neo-natale, Centre Hospitalier de Polynesie Francaise, Pirae, Tahiti, French Polynesia.; Service d'Obstetrique, Centre Hospitalier de Polynesie Francaise, Pirae, Tahiti, French Polynesia.; Service de Medecine Foetale, Hopital d'Enfants Armand-Trousseau, Universite Pierre et Marie Curie, Paris, France.; Department of Radiology, Hopital d'Enfants Armand-Trousseau, 26 Avenue du Dr Arnold Netter, Paris, France. catherine.garel@aphp.fr.",French Polynesia,Pacific,French Polynesia,Not reported/unknown,Brain; Fetus; Intrauterine infection; Magnetic resonance imaging; Prenatal diagnosis; Ultrasound; Zika virus,"BACKGROUND: An outbreak of Zika virus was observed in French Polynesia in 2013-2014. Maternal Zika virus infection has been associated with fetal microcephaly and severe cerebral damage. OBJECTIVE: To analyze the MRI cerebral findings in fetuses with intrauterine Zika virus infection. MATERIALS AND METHODS: We retrospectively analyzed prospectively collected data. Inclusion criteria comprised cases with (1) estimated conception date between June 2013 and May 2014, (2) available US and MRI scans revealing severe fetal brain lesions and (3) positive polymerase chain reaction for Zika virus in the amniotic fluid. We recorded pregnancy history of Zika virus infection and analyzed US and MRI scans. RESULTS: Three out of 12 cases of severe cerebral lesions fulfilled all inclusion criteria. History of maternal Zika virus infection had been documented in two cases. Calcifications and ventriculomegaly were present at US in all cases. MRI showed micrencephaly (n = 3), low cerebellar biometry (n = 2), occipital subependymal pseudocysts (n = 2), polymicrogyria with laminar necrosis and opercular dysplasia (n = 3), absent (n = 1) or hypoplastic (n = 1) corpus callosum and hypoplastic brainstem (n = 1). CONCLUSION: Severe cerebral damage was observed in our series, with indirect findings suggesting that the germinal matrix is the principal target for Zika virus. The lesions are very similar to severe forms of congenital cytomegalovirus and lymphocytic choriomeningitis virus infections.",Pubmed,May 30, 2016,Yes,,Yes,,Scientific (journal) article,Yes,Original research,Yes,No,542,Clinical/epidemiological research,Case series
842,"Kostyuchenko, Nature, 2016",Kostyuchenko,"Kostyuchenko, V. A.; Lim, E. X.; Zhang, S.; Fibriansah, G.; Ng, T. S.; Ooi, J. S.; Shi, J.; Lok, S. M.",Structure of the thermally stable Zika virus,Nature,533,7603,425-8,2016,2010-present,April 20, 2016,27093288,10.1038/nature17994,2464,English,http://www.ncbi.nlm.nih.gov/pubmed/27093288,"Program in Emerging Infectious Diseases, Duke-National University of Singapore Medical School, Singapore 169857, Singapore.; Centre for BioImaging Sciences, Department of Biological Sciences, National University of Singapore, Singapore 117557, Singapore.; CryoEM unit, Department of Biological Sciences, National University of Singapore, Singapore 117557, Singapore.",,,,Not reported/unknown,"Cryoelectron Microscopy; Dengue Virus/chemistry/classification/pathogenicity; Encephalitis Virus, Japanese/chemistry; Humans; Models, Molecular; Protein Stability; Saliva/virology; Semen/virology; *Temperature; Urine/virology; Viral Envelope Proteins/chemistry; Virion/*chemistry/pathogenicity/*ultrastructure; West Nile virus/chemistry; Zika Virus/*chemistry/pathogenicity/*ultrastructure","Zika virus (ZIKV), formerly a neglected pathogen, has recently been associated with microcephaly in fetuses, and with Guillian-Barre syndrome in adults. Here we present the 3.7 A resolution cryo-electron microscopy structure of ZIKV, and show that the overall architecture of the virus is similar to that of other flaviviruses. Sequence and structural comparisons of the ZIKV envelope (E) protein with other flaviviruses show that parts of the E protein closely resemble the neurovirulent West Nile and Japanese encephalitis viruses, while others are similar to dengue virus (DENV). However, the contribution of the E protein to flavivirus pathobiology is currently not understood. The virus particle was observed to be structurally stable even when incubated at 40 degrees C, in sharp contrast to the less thermally stable DENV. This is also reflected in the infectivity of ZIKV compared to DENV serotypes 2 and 4 (DENV2 and DENV4) at different temperatures. The cryo-electron microscopy structure shows a virus with a more compact surface. This structural stability of the virus may help it to survive in the harsh conditions of semen, saliva and urine. Antibodies or drugs that destabilize the structure may help to reduce the disease outcome or limit the spread of the virus.",Pubmed,May 30, 2016,Yes,,No,"Zika, indirect evidence or other topic",Scientific (journal) article,Yes,Original research,No,Yes,842,Basic and applied biomedical research,Biochemical/protein structure studies
843,"Walsh, Time, 2016",Walsh,"Walsh, B.",Why the Zika outbreak marks a new normal for infectious disease,Time,187,4,09. Okt,2016,2010-present,April 20, 2016,27089758,,2477,English,http://www.ncbi.nlm.nih.gov/pubmed/27089758,,,,,,Humans; *Pandemics; Zika Virus/*isolation & purification; Zika Virus Infection/*epidemiology,,Pubmed,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,News item or lay press,,,No,Yes,843,,
844,"Brett-Major, J R Coll Physicians Edinb, 2016",Brett-Major,"Brett-Major, D. M.; Roth, C. E.","Zika virus, emergencies, uncertainty and vulnerable populations",J R Coll Physicians Edinb,46,1,03. Jun,2016,2010-present,April 20, 2016,27092361,10.4997/JRCPE.2016.102,2292,English,http://www.ncbi.nlm.nih.gov/pubmed/27092361,"DM Brett-Major, 5902 Greentree Road, Bethesda, MD 20817-3460, USA. Email dmbrettmajor@gmail.com.",,,,,Flavivirus; Zika; microcephaly; outbreak; public health emergency,,Pubmed,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,844,,
845,"Schuler-Faccini, Clin Pharmacol Ther, 2016",Schuler-Faccini,"Schuler-Faccini, L.; Sanseverino, M.; Vianna, F.; da Silva, A. A.; Larrandaburu, M.; Marcolongo-Pereira, C.; Abeche, A. M.",Zika virus: A new human teratogen? Implications for women of reproductive age,Clin Pharmacol Ther,100,1,28-30,2016,2010-present,April 20, 2016,27090438,10.1002/cpt.386,2480,English,http://www.ncbi.nlm.nih.gov/pubmed/27090438,"SIAT, Brazilian Teratogen Information Service, Medical Genetics Service, Hospital de Clinicas de Porto Alegre, Brazil.; Post-Graduate Program in Genetics and Molecular Biology, Federal University of Rio Grande do Sul, Brazil.; UNIVATES University, Brazil.; Veterinary Sciences Faculty, UniRitter Laureate International Universities, Brazil.; Obstetrics and Gynecology Department, Federal University of Rio Grande do Sul, Brazil.",,,,,antiviral; microcephaly; pregnancy; teratogen; zika,"In 2015 an unprecedented increase of reports of newborns with microcephaly in Brazil made news headlines around the world. A possible etiological association with prenatal maternal infection by Zika virus (ZIKV) was suggested based on temporal and geographic distribution of ZIKV infection and the subsequent increase in the reports of microcephaly cases. Here we discuss ZIKV as a new human teratogen, with comments on potential treatment options.",Pubmed,May 30, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,845,,
846,"Walsh, Time, 2016",Walsh,"Walsh, B.; Sifferlin, A.",Zika's Toll,Time,187,5,42-7,2016,2010-present,April 20, 2016,27089761,,2508,English,http://www.ncbi.nlm.nih.gov/pubmed/27089761,,,,,,Congenital Abnormalities/virology; Humans; Incidence; Internationality; Microcephaly/virology; Zika Virus/*pathogenicity; *Zika Virus Infection/complications/epidemiology/transmission,,Pubmed,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,News item or lay press,,,No,Yes,846,,
847,"PAHO, , 2016",PAHO,PAHO,Epidemiological Update. Zika virus infection - 21 April 2016,,,,,2016,2010-present,April 21, 2016,,,2704,,http://www.paho.org/hq/index.php?option=com_docman&task=doc_view&Itemid=270&gid=34243&lang=en,,United States,Americas,,Public/Government,,,PAHO,May 30, 2016,No,Duplicate of existing record,,,,,,,,,,
848,"Ventura, Cad Saude Publica, 2016",Ventura,"Ventura, D. F.",From Ebola to Zika: international emergencies and the securitization of global health,Cad Saude Publica,32,4,e00033316,2016,2010-present,April 21, 2016,27096300,10.1590/0102-311X00033316,2565,English,http://www.ncbi.nlm.nih.gov/pubmed/27096300,"Instituto de Relacoes Internacionais, Universidade de Sao Paulo, Sao Paulo, Brazil.",,,,,,,Pubmed,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,848,,
849,", ED Manag, 2016",,,Public health authorities race to contain fast-moving Zika outbreak,ED Manag,28,4,37-41,2016,2010-present,April 21, 2016,27093766,,2327,English,http://www.ncbi.nlm.nih.gov/pubmed/27093766,,,,,,"Aedes/virology; Animals; Centers for Disease Control and Prevention (U.S.); Disease Outbreaks/*prevention & control; Emergency Service, Hospital/*organization & administration; Female; Humans; Insect Vectors; Male; Pregnancy; *Public Health; Puerto Rico/epidemiology; Sexually Transmitted Diseases, Viral/epidemiology/*prevention &; control/transmission; United States/epidemiology; Zika Virus Infection/epidemiology/*prevention & control/transmission","With the Zika virus disease spreading rapidly through Latin America, public health authorities in the United States are racing to contain the outbreak. By the end of February, the CDC had confirmed 147 Zika cases in U.S. residents who had traveled to Zika-endemic areas. While symptoms of Zika tend to be mild, the virus has been linked to serious birth defects, so public health efforts are focused primarily at mitigating the risk Zika poses to pregnant women. By mid-February, nine pregnant women who had traveled to Zika-endemic areas and contracted the virus had been reported to the CDC. Of these, four pregnancies ended in miscarriage or termination, and one child was born with microcephaly. While Zika is transmitted primarily via mosquito bites, the CDC is investigating more than a dozen reported cases of Zika transmitted via sexual contact. Public health authorities say Zika can trigger Guillain-Barre syndrome in a small number of infections. For frontline clinicians, travel history is key to identifying potential cases of Zika in pregnant women who may have been exposed. The FDA has expedited approval of a new test that can detect antibodies to Zika. The CDC is in the process of providing the test to labs across the country, with a priority on public health departments.",Pubmed,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,Other,,,No,Yes,849,,
850,"Gyawali, Infect Dis Poverty, 2016",Gyawali,"Gyawali, N.; Bradbury, R. S.; Taylor-Robinson, A. W.",The global spread of Zika virus: is public and media concern justified in regions currently unaffected?,Infect Dis Poverty,5,1,37,2016,2010-present,April 21, 2016,27093860,10.1186/s40249-016-0132-y,2439,English,http://www.ncbi.nlm.nih.gov/pubmed/27093860,"Infectious Diseases Research Group, School of Medical & Applied Sciences, Central Queensland University, Rockhampton, 4702, QLD, Australia.; Infectious Diseases Research Group, School of Medical & Applied Sciences, Central Queensland University, Rockhampton, 4702, QLD, Australia. a.taylor-robinson@cqu.edu.au.",,,,,Aedes; Arbovirus; Diagnosis; Epidemic; Flavivirus; Mosquito; Transmission; Treatment; Vector control; Zika,"BACKGROUND: Zika virus, an Aedes mosquito-borne flavivirus, is fast becoming a worldwide public health concern following its suspected association with over 4000 recent cases of microcephaly among newborn infants in Brazil. DISCUSSION: Prior to its emergence in Latin America in 2015-2016, Zika was known to exist at a relatively low prevalence in parts of Africa, Asia and the Pacific islands. An extension of its apparent global dispersion may be enabled by climate conditions suitable to support the population growth of A. aegypti and A. albopictus mosquitoes over an expanding geographical range. In addition, increased globalisation continues to pose a risk for the spread of infection. Further, suspicions of alternative modes of virus transmission (sexual and vertical), if proven, provide a platform for outbreaks in mosquito non-endemic regions as well. Since a vaccine or anti-viral therapy is not yet available, current means of disease prevention involve protection from mosquito bites, excluding pregnant females from travelling to Zika-endemic territories, and practicing safe sex in those countries. Importantly, in countries where Zika is reported as endemic, caution is advised in planning to conceive a baby until such time as the apparent association between infection with the virus and microcephaly is either confirmed or refuted. The question arises as to what advice is appropriate to give in more economically developed countries distant to the current epidemic and in which Zika has not yet been reported. Despite understandable concern among the general public that has been fuelled by the media, in regions where Zika is not present, such as North America, Europe and Australia, at this time any outbreak (initiated by an infected traveler returning from an endemic area) would very probably be contained locally. Since Aedes spp. has very limited spatial dispersal, overlapping high population densities of mosquitoes and humans would be needed to sustain a focus of infection. However, as A. aegypti is distinctly anthropophilic, future control strategies for Zika should be considered in tandem with the continuing threat to human wellbeing that is presented by dengue, yellow fever and Japanese encephalitis, all of which are transmitted by the same vector species.",Pubmed,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,850,,
851,"Galli, Cad Saude Publica, 2016",Galli,"Galli, B.; Deslandes, S.",Threats of retrocession in sexual and reproductive health policies in Brazil during the Zika epidemic,Cad Saude Publica,32,4,e00031116,2016,2010-present,April 21, 2016,27096299,10.1590/0102-311X00031116,2381,English,http://www.ncbi.nlm.nih.gov/pubmed/27096299,"Ipas Brasil, Rio de Janeiro, Brasil.; Instituto Nacional de Saude da Mulher, da Crianca e do Adolescente Fernandes Figueira, Fundacao Oswaldo Cruz, Rio de Janeiro, Brazil.",,,,,,,Pubmed,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,851,,
852,"WHO, , 2016",WHO,WHO,"Zika situation report. Zika virus, Microcephaly and Guillain-Barré syndrome - 21 April 2016",,,,,2016,2010-present,April 21, 2016,,,2720,,http://www.who.int/emergencies/zika-virus/situation-report/21-april-2016/en/,,Switzerland,Europe,,Public/Government,,,WHO,May 30, 2016,Yes,,No,"Zika, indirect evidence or other topic",Surveillance report or data,,,No,Yes,852,Clinical/epidemiological research,Ecological study/outbreak report
853,"Wiwanitkit, Br J Oral Maxillofac Surg, 2016",Wiwanitkit,"Wiwanitkit, V.",Zika virus and maxillofacial surgery,Br J Oral Maxillofac Surg,,,,2016,2010-present,April 21, 2016,27094497,10.1016/j.bjoms.2016.04.001,2594,English,http://www.ncbi.nlm.nih.gov/pubmed/27094497,"Adjunct Professor, Joseph Ayobabalola University, Nigeria; Visiting professor, Hainan Medical University; professor, senior expert, Surin Rajabhat University, Thailand. Electronic address: wviroj@yahoo.com.",,,,,,,Pubmed,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,853,,
854,"Coyle, Nursing, 2016",Coyle,"Coyle, A. L.",Zika virus: What nurses need to know,Nursing,46,5,22. Apr,2016,2010-present,April 21, 2016,27096910,10.1097/01.NURSE.0000482279.79660.bb,2338,English,http://www.ncbi.nlm.nih.gov/pubmed/27096910,"Amanda Coyle is an assistant professor at The College at Brockport in Brockport, N.Y.",,,,,,,Pubmed,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,854,,
855,"Shrinet, Bull World Health Organ, 2016",Shrinet,"Shrinet, Jatin; Agrawal, Aditi; Bhatnagar, Raj K.; Sunil, Sujatha",Analysis of the genetic divergence in Asian strains of ZIKA virus with reference to 2015-2016 outbreaks,Bull World Health Organ,published online 22.04.2016 (submitted 20.04.2016),,,2016,2010-present,April 22, 2016,,10.2471/blt.16.176065,2698,,http://www.who.int/bulletin/online_first/16-176065.pdf,,,,,,,"Objective: To compare Zika virus (ZIKV) genomes of the 2015-2016 outbreaks with the older strains and evaluate evolution of ZIKV. Method: We performed several genetic analyses to 50 ZIKV genomes currently available in the public domain. hylogenetic and mutation analysis, recombination analysis, molecular evolution and selection analysis identified amino acid variations that were unique to the 2015-2016 outbreak strains and the status of recombination and evolution amongst these sequences. Findings: We report distinct amino acid variations in the structural and nonstructural  proteins of all 2015-2016 outbreak strains that are conserved amongst these strains. Our results also reveal unique motifs in the UTRs of the new ZIKV strains. We identified recombination events in the African strains but not in the recent isolates of  Asian lineage. Population level analysis revealed over dominant selection of alleles in the genome.  Conclusion: 2015-2016 strains of ZIKV show distinct molecular signatures in their genomes that are conserved across strains isolated from different parts of the globe during the outbreak period. Our analysis at the population level emphasizes on a  possibility of balancing selection of the alleles.",WHO Zika open,May 30, 2016,Yes,,No,"Zika, indirect evidence or other topic",Scientific (journal) article,No,Original research,No,Yes,855,Basic and applied biomedical research,Sequence analysis and phylogenetics
856,"ECDC, , 2016",ECDC,ECDC,Epidemiological update. Outbreaks of Zika virus and complication potentially linked to the Zika virus infection - 22 April 2016,,,,,2016,2010-present,April 22, 2016,,,2219,,http://ecdc.europa.eu/en/press/news/_layouts/forms/News_DispForm.aspx?ID=1401&List=8db7286c-fe2d-476c-9133-18ff4cb1b568&Source=http%3A%2F%2Fecdc.europa.eu%2Fen%2Fhealthtopics%2Fzika_virus_infection%2FPages%2Fepidemiological-updates.aspx,,Sweden,Europe,,Public/Government,,,ECDC,May 30, 2016,Yes,,No,"Zika, indirect evidence or other topic",Surveillance report or data,,,No,Yes,856,Clinical/epidemiological research,Ecological study/outbreak report
857,"Gupta, Niger Postgrad Med J, 2016",Gupta,"Gupta, N.; Randhawa, R. K.; Thakar, S.; Bansal, M.; Gupta, P.; Arora, V.","Knowledge regarding Zika virus infection among dental practitioners of tricity area (Chandigarh, Panchkula and Mohali), India",Niger Postgrad Med J,23,1,33-7,2016,2010-present,April 22, 2016,27098947,10.4103/1117-1936.180179,2405,English,http://www.ncbi.nlm.nih.gov/pubmed/27098947,"Department of Public Health Dentistry, Swami Devi Dyal Hospital and Dental College, Barwala, Panchkula, Haryana, India.",,,,,,"BACKGROUND: Zika virus (ZIKV), a vector-borne virus affecting a large number of people, has today become a major public health concern in the developed and developing countries worldwide. AIM: The purpose of this study was to assess the knowledge of ZIKV among dental practitioners residing in Tricity area (Chandigarh, Panchkula and Mohali), India. SUBJECTS AND METHODS: A total of 412 private dental practitioners were randomly sampled of whom 254 (61.6%) responded to participate in this cross-sectional survey. A self-structured, closed-ended questionnaire was administered to each participant to record demographic and professional characteristics followed by their knowledge regarding ZIKV. Statistical analysis was performed using SPSS Version 20 (IBM Corp, Armonk, NY). The results were expressed in percentages. Multivariable linear regression analysis was carried out to assess the association of participant's demographics and professional characteristics with knowledge. RESULTS: The sample consisted of 152 (59.9%) male and 102 (40.1%) female practitioners. Majority of the practitioners belonged to the age group of 25-34 years (66.1%). High knowledge was reported by only 38.2% of the practitioners. A statistically significant difference was seen when mean knowledge scores were compared with the qualification of the participants (P = 0.04), with postgraduates having more knowledge than graduates regarding ZIKV. Most of the knowledge of the practitioners came from television (37.8%) while journals only represented 4.7% of the total information gained. CONCLUSION: ZIKV infection, a new public health emergency, needs to be addressed urgently. All health care professionals should have adequate knowledge of the virus and be conversant with necessary precautionary measures to be taken making it imperative that dental practitioners strive to continually update their knowledge from time to time.",Pubmed,May 30, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Unknown/unclear,Original research,No,Yes,857,Clinical/epidemiological research,Qualitative study
858,"Bullerdiek, Mol Cytogenet, 2016",Bullerdiek,"Bullerdiek, J.; Dotzauer, A.; Bauer, I.",The mitotic spindle: linking teratogenic effects of Zika virus with human genetics?,Mol Cytogenet,9,,32,2016,2010-present,April 22, 2016,27099632,10.1186/s13039-016-0240-1,2274,English,http://www.ncbi.nlm.nih.gov/pubmed/27099632,"Centre for Human Genetics, University of Bremen, Leobener Str. ZHG, D-28359 Bremen, Germany ; Institute of Medical Genetics, University Rostock Medical Center, Ernst-Heydemann-Strasse 8, D-18057 Rostock, Germany.; Laboratory of Virus Research, University of Bremen, Leobener Strasse/UFT, 28359, D-28359 Bremen, Germany.; Institute of Medical Genetics, University Rostock Medical Center, Ernst-Heydemann-Strasse 8, D-18057 Rostock, Germany.",Germany,Europe,Germany,,Chorioretinopathy; Genetics; Mechanisms; Microcephaly; Phenocopy; Syndromes; Zika virus,"BACKGROUND: Recently, an association between Zika virus infection and microcephaly/ocular findings was found to be reasonable e.g. because of the demonstration that the virus was found in the brain of a fetus after presumed maternal infection. Although there is no proof yet for a causal relationship, for an appropriate risk calculation efforts are urgently needed to either establish or disprove this assumption. PRESENTATION OF THE HYPOTHESIS: On the basis of inherited syndromes combining microcephaly with ocular findings similar to those associated with Zika infections, we have hypothesized that the impairment of the proper function of the mitotic apparatus is a possible mechanism by which Zika can exert teratogenic effects. TESTING THE HYPOTHESIS: A bundle of well-known cytogenetic and molecular-cytogenetic methods (e.g. formation of micronuclei, chromosomal lagging, immunofluorescence of centrosomes) to evaluate proper function, maintenance, and establishment of the mitotic spindle poles can be applied on infected cells. Also, the viral proteins can be tested for their possible interaction with proteins encoded by genes involved in inherited syndromes with microcephaly and ocular findings resembling those in presumed cases of intrauterine ZIKV infection. IMPLICATIONS OF THE HYPOTHESIS: Once proved, this hypothesis allows for a targeted approach into mechanisms of possible relevance as e.g. if different strains of the virus are implicated in the teratogenic effects to the same or a different extent.",Pubmed,May 30, 2016,Yes,,No,"Zika, indirect evidence or other topic",Scientific (journal) article,Unknown/unclear,Review,No,Yes,858,Basic and applied biomedical research,Basic research review
859,", Nature, 2016",,,Virology: Zika protein structure solved,Nature,532,7599,285-285,2016,2010-present,April 22, 2016,27099009,10.1038/532285a,2278,English,http://www.nature.com/nature/journal/v532/n7599/pdf/532285a.pdf,,,,,,,,Pubmed,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,News item or lay press,,,No,Yes,859,,
860,"Southwell, Emerg Infect Dis, 2016",Southwell,"Southwell, B. G.; Dolina, S.; Jimenez-Magdaleno, K.; Squiers, L. B.; Kelly, B. J.","Zika Virus-Related News Coverage and Online Behavior, United States, Guatemala, and Brazil",Emerg Infect Dis,22,7,1320-1,2016,2010-present,April 22, 2016,27100826,10.3201/eid2207.160415,2475,English,http://www.ncbi.nlm.nih.gov/pubmed/27100826,,,,,,Brazil; Guatemala; Internet; Twitter; United States; Zika virus; communications; flavivirus; mass media; media; messaging; social media; viruses,,Pubmed,May 30, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Unknown/unclear,Original research,No,Yes,860,Clinical/epidemiological research,Qualitative study
861,"Guzzetta, Eurosurveillance, 2016",Guzzetta,"Guzzetta, G.; Poletti, P.; Montarsi, F.; Baldacchino, F.; Capelli, G.; Rizzoli, A.; Rosa, R.; Merler, S.",Assessing the potential risk of Zika virus epidemics in temperate areas with established Aedes albopictus populations,Eurosurveillance,21,15,,2016,2010-present,April 23, 2016,27104366,10.2807/1560-7917.ES.2016.21.15.30199,2372,English,http://www.ncbi.nlm.nih.gov/pubmed/27104366,"Fondazione Bruno Kessler, Trento, Italy.",,,,,Zika virus; imported viral diseases; outbreaks; vector-borne infections,"Based on 2015 abundance of Aedes albopictus in nine northern Italian municipalities with temperate continental/oceanic climate, we estimated the basic reproductive number R0 for Zika virus (ZIKV) to be systematically below the epidemic threshold in most scenarios. Results were sensitive to the value of the probability of mosquito infection after biting a viraemic host. Therefore, further studies are required to improve models and predictions, namely evaluating vector competence and potential non-vector transmissions.",Pubmed,May 30, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Original research,No,Yes,861,Clinical/epidemiological research,Modelling study
862,"Liu, Genome Announc, 2016",Liu,"Liu, L.; Wu, W.; Zhao, X.; Xiong, Y.; Zhang, S.; Liu, X.; Qu, J.; Li, J.; Nei, K.; Liang, M.; Shu, Y.; Hu, G.; Ma, X.; Li, D.",Complete Genome Sequence of Zika Virus from the First Imported Case in Mainland China,Genome Announc,4,2,,2016,2010-present,April 23, 2016,27103718,10.1128/genomeA.00291-16,2440,English,http://www.ncbi.nlm.nih.gov/pubmed/27103718,"NHFPC Key Laboratory for Medical Virology, National Institute for Viral Disease Control and Prevention, China CDC, Beijing, China.; Jiangxi Province CDC, Nanchang, China.; NHFPC Key Laboratory for Medical Virology, National Institute for Viral Disease Control and Prevention, China CDC, Beijing, China lidx@Chinacdc.cn maxj@ivdc.chinacdc.cn.",,,,,,The first case of Zika virus infection was identified in a Chinese traveler returning from Venezuela in February 2016. This report describes the complete genome sequence of Zika virus from the first imported case in China. The genome sequence analysis showed that the Zika virus isolated in this case belongs to the Asian lineage.,Pubmed,May 30, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Unknown/unclear,Original research,No,Yes,862,Basic and applied biomedical research,Sequence analysis and phylogenetics
863,"Velo, Parasit Vectors, 2016",Velo,"Velo, E.; Kadriaj, P.; Mersini, K.; Shukullari, A.; Manxhari, B.; Simaku, A.; Hoxha, A.; Caputo, B.; Bolzoni, L.; Rosa, R.; Bino, S.; Reiter, P.; Della Torre, A.",Enhancement of Aedes albopictus collections by ovitrap and sticky adult trap,Parasit Vectors,9,1,223,2016,2010-present,April 23, 2016,27102015,10.1186/s13071-016-1501-x,2547,English,http://www.ncbi.nlm.nih.gov/pubmed/27102015,"Control of Infectious Diseases Department, Institute of Public Health, Tirana, Albania. keladikolli@yahoo.com.; Control of Infectious Diseases Department, Institute of Public Health, Tirana, Albania.; National Veterinary Epidemiology Unit, Food Safety and Veterinary Institute, Tirana, Albania.; Department of Biology, Faculty of Natural Sciences, Tirana, Albania.; Dipartimento di Sanita Pubblica e Malattie Infettive, Universita di Roma 'Sapienza', Rome, Italy.; Istituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia Romagna, Parma, Italy.; Dipartimento di Biodiversita ed Ecologia Molecolare, Centro Ricerca e Innovazione, Fondazione Edmund Mach, San Michele all'Adige, Trento, Italy.; Insects and Infectious Disease Unit, Institute Pasteur, Paris, France.",,,,,Aedes; Albania; Europe; Hay-infusion; Mosquito monitoring; Mosquito surveillance; Ovitrap; Sticky trap,"BACKGROUND: In the last decades, Aedes albopictus has become an increasing public health threat in tropical as well as in more recently invaded temperate areas due to its capacity to transmit several human arboviruses, among which Dengue, Chikungunya and Zika. Enhancing the efficiency of currently used collection approaches, such as ovitraps and sticky traps, is desirable for optimal monitoring of the species abundance, for assessment of the risk of arbovirus transmission and for the optimisation of control activities. FINDINGS: Two sets of 4 x 4 Latin-square experiments were carried out in Tirana (Albania) to test whether modifications in ovitrap shape and size and in oviposition substrate would increase collections of Ae. albopictus eggs and whether hay-infusion would increase adult catches by sticky trap. Generalized Linear Mixed Models with negative binomial error distribution were carried out to analyse the data. Cylindrical ovitraps lined with germination paper yielded significantly higher egg catches than those exploiting either the (commonly used) wooden paddles or floating polystyrene blocks as oviposition substrates. No difference was observed between cylindrical and conical shaped ovitraps. Ovitraps and sticky traps baited with hay infusion yielded significantly higher egg and adult catches than un-baited ones. A significant relationship between ovitrap and sticky trap catches was observed both in the absence and in the presence of attractants, with ovitrap catches increasing more than sticky trap catches at increasing adult female densities. CONCLUSIONS: This study provides grounds for optimisation of ovitraps and sticky traps as monitoring tools for Ae. albopictus by (i) supporting use of germination paper as most appropriate oviposition substrate; (ii) suggesting the possible use of stackable conical ovitraps for large scale monitoring; (iii) confirming the use of hay-infusion to increase egg catches in ovitraps, and showing that hay-infusion also significant increases adult catches by sticky traps.",Pubmed,May 30, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Original research,No,Yes,863,Environmental and vector research,Other ecological
864,"Dasgupta, MMWR Morb Mortal Wkly Rep, 2016",Dasgupta,"Dasgupta, S.; Reagan-Steiner, S.; Goodenough, D.; Russell, K.; Tanner, M.; Lewis, L.; Petersen, E. E.; Powers, A. M.; Kniss, K.; Meaney-Delman, D.; Oduyebo, T.; O'Leary, D.; Chiu, S.; Talley, P.; Hennessey, M.; Hills, S.; Cohn, A.; Gregory, C.; Zika Virus Response, Epidemiology; Laboratory, Team; Cdc,; Cdc,","Patterns in Zika Virus Testing and Infection, by Report of Symptoms and Pregnancy Status - United States, January 3-March 5, 2016",MMWR Morb Mortal Wkly Rep,65,15,395-9,2016,2010-present,April 23, 2016,27101541,10.15585/mmwr.mm6515e1,2314,English,http://www.ncbi.nlm.nih.gov/pubmed/27101541,,,,,,,"CDC recommends Zika virus testing for potentially exposed persons with signs or symptoms consistent with Zika virus disease, and recommends that health care providers offer testing to asymptomatic pregnant women within 12 weeks of exposure. During January 3-March 5, 2016, Zika virus testing was performed for 4,534 persons who traveled to or moved from areas with active Zika virus transmission; 3,335 (73.6%) were pregnant women. Among persons who received testing, 1,541 (34.0%) reported at least one Zika virus-associated sign or symptom (e.g., fever, rash, arthralgia, or conjunctivitis), 436 (9.6%) reported at least one other clinical sign or symptom only, and 2,557 (56.4%) reported no signs or symptoms. Among 1,541 persons with one or more Zika virus-associated symptoms who received testing, 182 (11.8%) had confirmed Zika virus infection. Among the 2,557 asymptomatic persons who received testing, 2,425 (94.8%) were pregnant women, seven (0.3%) of whom had confirmed Zika virus infection. Although risk for Zika virus infection might vary based on exposure-related factors (e.g., location and duration of travel), in the current setting in U.S. states, where there is no local transmission, most asymptomatic pregnant women who receive testing do not have Zika virus infection.",Pubmed,May 30, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,No,Original research,No,Yes,864,Clinical/epidemiological research,Case series
865,"Cordeiro, Lancet, 2016",Cordeiro,"Cordeiro, M. T.; Pena, L. J.; Brito, C. A.; Gil, L. H.; Marques, E. T.",Positive IgM for Zika virus in the cerebrospinal fluid of 30 neonates with microcephaly in Brazil,Lancet,387,10030,1811-2,2016,2010-present,April 23, 2016,27103126,10.1016/S0140-6736(16)30253-7,2291,English,http://www.ncbi.nlm.nih.gov/pubmed/27103126,"Department of Virology, Centro de Pesquisas Aggeu Magalhaes-CPqAM, Fiocruz, Recife, PE 50670-420, Brazil. Electronic address: marli@cpqam.fiocruz.br.; Department of Virology, Centro de Pesquisas Aggeu Magalhaes-CPqAM, Fiocruz, Recife, PE 50670-420, Brazil.; Department of Clinical Medicine, Federal University of Pernambuco, Recife, Brazil.; Department of Virology, Centro de Pesquisas Aggeu Magalhaes-CPqAM, Fiocruz, Recife, PE 50670-420, Brazil; Center for Vaccine Research, University of Pittsburgh, Pittsburgh, PA, USA.",Brazil,Americas,United States,,"Brazil; Enzyme-Linked Immunosorbent Assay; Humans; Immunoglobulin M/*cerebrospinal fluid; Infant; Infant, Newborn; Microcephaly/*cerebrospinal fluid; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; Zika Virus/*isolation & purification; Zika Virus Infection/*cerebrospinal fluid",,Pubmed,May 30, 2016,Yes,,Yes,,Scientific (journal) article,Unknown/unclear,Original research,Yes,No,758,Clinical/epidemiological research,Case series
866,"Dickson, PLoS Negl Trop Dis, 2016",Dickson,"Dickson, L. B.; Sharakhova, M. V.; Timoshevskiy, V. A.; Fleming, K. L.; Caspary, A.; Sylla, M.; Black, W. C. th",Reproductive Incompatibility Involving Senegalese Aedes aegypti (L) Is Associated with Chromosome Rearrangements,PLoS Negl Trop Dis,10,4,e0004626,2016,2010-present,April 23, 2016,27105225,10.1371/journal.pntd.0004626,2329,English,http://www.ncbi.nlm.nih.gov/pubmed/27105225,"Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, United States of America.; Department of Entomology, Fralin Life Science Institute, Virginia Tech, Blacksburg, Virginia, United States of America.",,,,,,"Aedes aegypti, the primary vector of dengue, yellow fever and Zika flaviviruses, consists of at least two subspecies. Aedes aegypti (Aaa) is light in color, has pale scales on the first abdominal tergite, oviposits in artificial containers, and preferentially feeds on humans. Aedes aegypti formosus (Aaf), has a dark cuticle, is restricted to sub-Saharan Africa, has no pale scales on the first abdominal tergite and frequently oviposits in natural containers. Scale patterns correlate with cuticle color in East Africa but not in Senegal, West Africa where black cuticle mosquitoes display a continuum of scaling patterns and breed domestically indoors. An earlier laboratory study did not indicate any pre- or postzygotic barriers to gene flow between Aaa and Aaf in East Africa. However, similar attempts to construct F1 intercross families between Aaa laboratory strains and Senegal Ae. aegypti (SenAae) failed due to poor F1 oviposition and low F2 egg-to-adult survival. Insemination and assortative mating experiments failed to identify prezygotic mating barriers. Backcrosses were performed to test for postzygotic isolation patterns consistent with Haldane's rule modified for species, like Aedes, that have an autosomal sex determining locus (SDL). Egg-pupal survival was predicted to be low in females mated to hybrid F1 males but average when a male mates with a hybrid F1 female. Survival was in fact significantly reduced when females mated to hybrid males but egg-pupal survival was significantly increased when males were mated to hybrid F1 females. These observations are therefore inconclusive with regards to Haldane's rule. Basic cytogenetic analyses and Fluorescent In Situ Hybridization (FISH) experiments were performed to compare SenAae strains with the IB12 strain of Aaa that was used for genome sequencing and physical mapping. Some SenAae strains had longer chromosomes than IB12 and significantly different centromeric indices on chromosomes 1 and 3. DAPI staining was used to identify AT-rich regions, chromomycin A3 following pretreatment with barium hydroxide stained for GC-rich regions and stained the ribosomal RNA locus and YOYO-1 was used to test for differential staining. Chromosome patterns in SenAae strains revealed by these three stains differed from those in IB12. For FISH, 40 BAC clones previously physically mapped on Aaa chromosomes were used to test for chromosome rearrangements in SenAae relative to IB12. Differences in the order of markers identified two chromosomal rearrangements between IB12 and SenAae strains. The first rearrangement involves two overlapping pericentric (containing the centromere) inversions in chromosome 3 or an insertion of a large fragment into the 3q arm. The second rearrangement is close to the centromere on the p arm of chromosome 2. Linkage analysis of the SDL and the white-eye locus identified a likely chromosomal rearrangement on chromosome 1. The reproductive incompatibility observed within SenAae and between SenAae and Aaa may be generally associated with chromosome rearrangements on all three chromosomes and specifically caused by pericentric inversions on chromosomes 2 and 3.",Pubmed,May 30, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Original research,No,Yes,866,Environmental and vector research,Other ecological
867,"Hussain, J Infect Public Health, 2016",Hussain,"Hussain, H. F.; Hafiz, M. Y.; Hussain, S. A.",Rumor has it; the truth behind Zika virus,J Infect Public Health,,,,2016,2010-present,April 23, 2016,27102926,10.1016/j.jiph.2016.04.004,2426,English,http://www.ncbi.nlm.nih.gov/pubmed/27102926,"Dow Medical College, Dow University of Health Sciences, Karachi, Pakistan.; Dow Medical College, Dow University of Health Sciences, Karachi, Pakistan. Electronic address: drsahussain121@gmail.com.",,,,,,,Pubmed,May 30, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,867,,
868,", Cell, 2016",,,What Will It Take to Respond to the Threat of Zika?,Cell,165,3,510-1,2016,2010-present,April 23, 2016,27104970,10.1016/j.cell.2016.03.027,2362,English,http://www.ncbi.nlm.nih.gov/pubmed/27104970,,,,,,,,Pubmed,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,868,,
869,"Kruger, Cell, 2016",Kruger,"Kruger, R. P.",Zika Research Shifts into High Gear,Cell,165,3,503-5,2016,2010-present,April 23, 2016,27104968,10.1016/j.cell.2016.04.026,2342,English,http://www.ncbi.nlm.nih.gov/pubmed/27104968,,,,,,,,Pubmed,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,News item or lay press,,,No,Yes,869,,
870,"Nielsen, Lancet, 2016",Nielsen,"Nielsen, K. K.; Bygbjerg, I. C.",Zika virus and hyperglycaemia in pregnancy,Lancet,387,10030,1812,2016,2010-present,April 23, 2016,27103128,10.1016/S0140-6736(16)30254-9,2516,English,http://www.ncbi.nlm.nih.gov/pubmed/27103128,"Global Health Section, Department of Public Health, University of Copenhagen, DK-1014 Copenhagen, Denmark. Electronic address: kani@sund.ku.dk.; Global Health Section, Department of Public Health, University of Copenhagen, DK-1014 Copenhagen, Denmark.",,,,,"Female; Humans; Hyperglycemia/*complications/epidemiology; Pregnancy; Pregnancy Complications, Infectious/*virology; Zika Virus/*pathogenicity; Zika Virus Infection/*complications/epidemiology",,Pubmed,May 30, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,870,,
871,"De Carvalho, Braz J Infect Dis, 2016",De Carvalho,"De Carvalho, N. S.; De Carvalho, B. F.; Fugaca, C. A.; Doris, B.; Biscaia, E. S.",Zika virus infection during pregnancy and microcephaly occurrence: a review of literature and Brazilian data,Braz J Infect Dis,20,3,282-9,2016,2010-present,April 23, 2016,27102780,10.1016/j.bjid.2016.02.006,2330,English,http://www.ncbi.nlm.nih.gov/pubmed/27102780,"Department of Gynecology and Obstetrics, Universidade Federal do Parana (UFPR), Infectious Diseases in Gynecology and Obstetrics Sector, Clinics Hospital and Postgraduate Education Program in Obstetrics and Universidade Federal do Parana (UFPR), Curitiba, PR, Brazil. Electronic address: newtonsdc@gmail.com.; Pontificia Universidade Catolica do Parana (PUC-PR), Curitiba, PR, Brazil.",,,,,Aedes mosquitoes; Microcephaly; Pregnancy; Zika virus,"In November of 2015, the Ministry of Health of Brazil published an announcement confirming the relationship between Zika virus and the microcephaly outbreak in the Northeast, suggesting that infected pregnant women might have transmitted the virus to their fetuses. The objectives of this study were to conduct a literature review about Zika virus infection and microcephaly, evaluate national and international epidemiological data, as well as the current recommendations for the health teams. Zika virus is an arbovirus, whose main vector is the Aedes sp. The main symptoms of the infection are maculopapular rash, fever, non-purulent conjunctivitis, and arthralgia. Transmission of this pathogen occurs mainly by mosquito bite, but there are also reports via the placenta. Microcephaly is defined as a measure of occipto-frontal circumference being more than two standard deviations below the mean for age and gender. The presence of microcephaly demands evaluation of the patient, in order to diagnose the etiology. Health authorities issued protocols, reports and notes concerning the management of microcephaly caused by Zika virus, but there is still controversy about managing the cases. The Ministry of Health advises notifying any suspected or confirmed cases of children with microcephaly related to the pathogen, which is confirmed by a positive specific laboratory test for the virus. The first choice for imaging exam in children with this malformation is transfontanellar ultrasound. The most effective way to control this outbreak of microcephaly probably caused by this virus is to combat the vector. Since there is still uncertainty about the period of vulnerability of transmission via placenta, the use of repellents is crucial throughout pregnancy. More investigations studying the consequences of this viral infection on the body of newborns and in their development are required.",Pubmed,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Yes,Review,No,Yes,871,Clinical/epidemiological research,Epidemiological/clinical review
872,"Del Carpio-Orantes, Rev Med Inst Mex Seguro Soc, 2016",Del Carpio-Orantes,"Del Carpio-Orantes, L.",[Emerging Arboviroses in Mexico: chikunguna and zika],Rev Med Inst Mex Seguro Soc,54,3,278-9,2016,2010-present,April 23, 2016,27100970,,2267,Spanish,http://www.ncbi.nlm.nih.gov/pubmed/27100970,"Departamento de Medicina Interna, Hospital General de Zona 71, Instituto Mexicano del Seguro Social, Veracruz, Mexico. neurona23@hotmail.com.",,,,,,,Pubmed,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,872,,
873,"Han, J Infect, 2016",Han,"Han, J. F.; Jiang, T.; Ye, Q.; Li, X. F.; Liu, Z. Y.; Qin, C. F.",Homologous recombination of Zika viruses in the Americas,J Infect,73,1,87-8,2016,2010-present,April 24, 2016,27105655,10.1016/j.jinf.2016.04.011,2435,English,http://www.ncbi.nlm.nih.gov/pubmed/27105655,"Department of Virology, State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, People's Republic of China.; Department of Virology, State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, People's Republic of China. Electronic address: qincf@bmi.ac.cn.",,,,,Zika virus (ZIKV); genotype; phylogenetics; recombination,,Pubmed,May 30, 2016,Yes,,No,"Zika, indirect evidence or other topic",Scientific (journal) article,Unknown/unclear,Original research,No,Yes,873,Basic and applied biomedical research,Sequence analysis and phylogenetics
874,"Deng, Virol Sin, 2016",Deng,"Deng, C.; Liu, S.; Zhang, Q.; Xu, M.; Zhang, H.; Gu, D.; Shi, L.; He, J.; Xiao, G.; Zhang, B.",Isolation and characterization of Zika virus imported to China using C6/36 mosquito cells,Virol Sin,31,2,176-9,2016,2010-present,April 24, 2016,27105638,10.1007/s12250-016-3778-5,2341,English,http://www.ncbi.nlm.nih.gov/pubmed/27105638,"Key Laboratory of Special Pathogens and Biosafety, Center for Emerging Infectious Diseases, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, 430071, China.; University of Chinese Academy of Sciences, Beijing, 100049, China.; The Central Laboratory of Health Quarantine, Shenzhen Travel Healthcare Center, Shenzhen Entry-Exit Inspection and Quarantine Bureau, Shenzhen, 518033, China.; State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, 430071, China.; Key Laboratory of Special Pathogens and Biosafety, Center for Emerging Infectious Diseases, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, 430071, China. zhangbo@wh.iov.cn.",,,,,,,Pubmed,May 30, 2016,Yes,,No,"Zika, not relevant to causality framework",Scientific (journal) article,Unknown/unclear,Original research,No,Yes,874,Basic and applied biomedical research,In vitro experiment
875,"Duarte Dos Santos, Trends Parasitol, 2016",Duarte Dos Santos,"Duarte Dos Santos, C. N.; Goldenberg, S.",Zika Virus and Microcephaly: Challenges for a Long-Term Agenda,Trends Parasitol,32,7,508-11,2016,2010-present,April 24, 2016,27105931,10.1016/j.pt.2016.03.008,2367,English,http://www.ncbi.nlm.nih.gov/pubmed/27105931,"Laboratorio de Virologia Molecular, Instituto Carlos Chagas, Fiocruz PR, Curitiba, PR, Brasil. Electronic address: clsantos@fiocruz.br.; Laboratorio de Regulacao da Expressao Genica(,) Instituto Carlos Chagas, Fiocruz PR, Curitiba, PR, Brasil.",,,,,,"Since its introduction in Brazil in 2015, Zika virus (ZIKV) has begun to spread worldwide. One of the major infection outcomes is related to congenital malformations, but little is known about the pathogenicity of ZIKV. Here we discuss concerns about the ongoing ZIKV epidemic in the context of academic research, politics, and society.",Pubmed,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,875,,
876,"Plotkin, Clin Microbiol Infect, 2016",Plotkin,"Plotkin, S. A.",Zika as still another argument for a new path to vaccine development,Clin Microbiol Infect,22,4,294-5,2016,2010-present,April 24, 2016,27107300,10.1016/j.cmi.2016.03.001,2494,English,http://www.ncbi.nlm.nih.gov/pubmed/27107300,"University of Pennsylvania, Philadelphia, PA, USA. Electronic address: Stanley.plotkin@vaxconsult.com.",,,,,,,Pubmed,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,876,,
877,"Harris, Am J Bioeth, 2016",Harris,"Harris, L. H.; Silverman, N. S.; Marshall, M. F.","The Paradigm of the Paradox: Women, Pregnant Women, and the Unequal Burdens of the Zika Virus Pandemic",Am J Bioeth,16,5,01. Apr,2016,2010-present,April 26, 2016,27111356,10.1080/15265161.2016.1177367,2395,English,http://www.ncbi.nlm.nih.gov/pubmed/27111356,"a School of Medicine , University of Michigan.; b David Geffen School of Medicine , UCLA.; c Schools of Medicine and Nursing , University of Virginia.",,,,,,,Pubmed,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,877,,
878,"Lednicky, PLoS Negl Trop Dis, 2016",Lednicky,"Lednicky, J.; Beau De Rochars, V. M.; El Badry, M.; Loeb, J.; Telisma, T.; Chavannes, S.; Anilis, G.; Cella, E.; Ciccozzi, M.; Rashid, M.; Okech, B.; Salemi, M.; Morris, J. G., Jr.",Zika Virus Outbreak in Haiti in 2014: Molecular and Clinical Data,PLoS Negl Trop Dis,10,4,e0004687,2016,2010-present,April 26, 2016,27111294,10.1371/journal.pntd.0004687,2448,English,http://www.ncbi.nlm.nih.gov/pubmed/27111294,"Emerging Pathogens Institute, University of Florida, Gainesville, Florida, United States of America.; Department of Environmental and Global Health, College of Public Health and Health Professions, University of Florida, Gainesville, Florida, United States of America.; Department of Health Services Research, Management, and Policy, College of Public Health and Health Professions, University of Florida, Gainesville, Florida, United States of America.; Christianville Foundation School Clinic, Gressier, Haiti.; Department of Pathology, Immunology, and Laboratory Sciences, College of Medicine, University of Florida, Gainesville, Florida, United States of America.; Department of Infectious Parasitic and Immunomediated Diseases, Reference Centre on Phylogeny, Molecular Epidemiology and Microbial Evolution (FEMEM)/Epidemiology Unit, Istituto Superiore di Sanita, Rome, Italy.; Department of Medicine, College of Medicine, University of Florida, Gainesville, Florida, United States of America.",,,,,,"BACKGROUND: Zika virus (ZIKV), first isolated in Uganda in 1947, is currently spreading rapidly through South America and the Caribbean. In Brazil, infection has been linked with microcephaly and other serious complications, leading to declaration of a public health emergency of international concern; however, there currently are only limited data on the virus (and its possible sources and manifestations) in the Caribbean. METHODS: From May, 2014-February, 2015, in conjunction with studies of chikungunya (CHIKV) and dengue (DENV) virus infections, blood samples were collected from children in the Gressier/Leogane region of Haiti who presented to a school clinic with undifferentiated febrile illness. Samples were initially screened by RT-PCR for CHIKV and DENV, with samples negative in these assays further screened by viral culture. FINDINGS: Of 177 samples screened, three were positive for ZIKV, confirmed by viral sequencing; DENV-1 was also identified in culture from one of the three positive case patients. Patients were from two different schools and 3 different towns, with all three cases occurring within a single week, consistent with the occurrence of an outbreak in the region. Phylogenetic analysis of known full genome viral sequences demonstrated a close relationship with ZIKV from Brazil; additional analysis of the NS5 gene, for which more sequences are currently available, showed the Haitian strains clustering within a monophyletic clade distinct from Brazilian, Puerto Rican and Guatemalan sequences, with all part of a larger clade including isolates from Easter Island. Phylogeography also clarified that at least three major African sub-lineages exist, and confirmed that the South American epidemic is most likely to have originated from an initial ZIKV introduction from French Polynesia into Easter Island, and then to the remainder of the Americas. CONCLUSIONS: ZIKV epidemics in South America, as well as in Africa, show complex dissemination patterns. The virus appears to have been circulating in Haiti prior to the first reported cases in Brazil. Factors contributing to transmission and the possible linkage of this early Haitian outbreak with microcephaly remain to be determined.",Pubmed,May 30, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Original research,No,Yes,878,Basic and applied biomedical research,Sequence analysis and phylogenetics
879,"Vanlandingham, J Med Entomol, 2016",Vanlandingham,"Vanlandingham, D. L.; Higgs, S.; Huang, Y. S.",Aedes albopictus (Diptera: Culicidae) and Mosquito-Borne Viruses in the United States,J Med Entomol,,,,2016,2010-present,April 27, 2016,27113107,10.1093/jme/tjw025,2482,English,http://www.ncbi.nlm.nih.gov/pubmed/27113107,"Diagnostic Medicine and Pathobiology, Kansas State University, Manhattan, KS (dlvanlan@vet.ksu.edu; shiggs@k-state.edu; yshuang1985@ksu.edu).; Diagnostic Medicine and Pathobiology, Kansas State University, Manhattan, KS (dlvanlan@vet.ksu.edu; shiggs@k-state.edu; yshuang1985@ksu.edu), Biosecurity Research Institute, Kansas State University, Manhattan, KS, and shiggs@k-state.edu.; Diagnostic Medicine and Pathobiology, Kansas State University, Manhattan, KS (dlvanlan@vet.ksu.edu; shiggs@k-state.edu; yshuang1985@ksu.edu), Biosecurity Research Institute, Kansas State University, Manhattan, KS, and.",,,,,Aedes albopictus; arbovirology; mosquito-borne,"The Asian tiger mosquito Aedes albopictus (Skuse), is a highly invasive species that continues to expand its geographic distribution both in the United States and in countries on other continents. Studies have demonstrated its susceptibility to infection with at least 32 viruses, including 13 that are present in the United States. Despite this susceptibility, its role as a significant competent vector in natural transmission cycles of arboviruses, has been limited. However, with the recent introductions of chikungunya and Zika viruses into the Americas, for which Ae. albopictus is a recognized vector, it is possible that the species may contribute to the transmission of these viruses to humans and perhaps other susceptible vertebrates.",Pubmed,May 30, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Review,No,Yes,879,Environmental and vector research,Ecological/Vector review
880,"Dieng, J Agric Food Chem, 2016",Dieng,"Dieng, H.; Tan Yusop, N. S.; Kamal, N. N.; Ahmad, A. H.; Ghani, I. A.; Abang, F.; Satho, T.; Ahmad, H.; Zuharah, W. F.; Majid, A. H.; Morales, R. E.; Morales, N. P.; Hipolito, C. N.; Noweg, G. T.","Exposure of a Dengue Vector to Tea and Its Waste: Survival, Developmental Consequences, and Significance for Pest Management",J Agric Food Chem,64,18,3485-91,2016,2010-present,April 27, 2016,27115536,10.1021/acs.jafc.6b01157,2299,English,http://www.ncbi.nlm.nih.gov/pubmed/27115536,"Institute of Biodiversity and Environmental Conservation (IBEC), Universiti Malaysia Sarawak , Kuching, Kota Samarahan, Malaysia.; School of Biological Sciences, Universiti Sains Malaysia , Penang, Malaysia.; Faculty of Science and Technology, Universiti Kebangsaan Malaysia , Bangi, Malaysia.; Faculty of Resource Science and Technology, Universiti Malaysia Sarawak , Kota Samarahan, Malaysia.; Faculty of Pharmaceutical Sciences, Fukuoka University , Fukuoka, Japan.; Department of Medical Entomology, Faculty of Tropical Medicine, Mahidol University , Bangkok, Thailand.; Department of Pharmacology, Faculty of Science, Mahidol University , Bangkok, Thailand.; Department of Chemical Engineering and Energy Sustainability, Faculty of Engineering, Universiti Malaysia , Sarawak, Malaysia.",,,,,Ae. albopictus; dengue; mosquito; tea,"Dengue mosquitoes are evolving into a broader global public health menace, with relentless outbreaks and the rise in number of Zika virus disease cases as reminders of the continued hazard associated with Aedes vectors. The use of chemical insecticides-the principal strategy against mosquito vectors-has been greatly impeded due to the development of insecticide resistance and the shrinking spectrum of effective agents. Therefore, there is a pressing need for new chemistries for vector control. Tea contains hundreds of chemicals, and its waste, which has become a growing global environmental problem, is almost as rich in toxicants as green leaves. This paper presents the toxic and sublethal effects of different crude extracts of tea on Aedes albopictus. The survival rates of larvae exposed to tea extracts, especially fresh tea extract (FTE), were markedly lower than those in the control treatment group. In addition to this immediate toxicity against different developmental stages, the extracts tested caused a broad range of sublethal effects. The developmental time was clearly longer in containers with tea, especially in those with young larvae (YL) and FTE. Among the survivors, pupation success was reduced in containers with tea, which also produced low adult emergence rates with increasing tea concentration. The production of eggs tended to be reduced in females derived from the tea treatment groups. These indirect effects of tea extracts on Ae. albopictus exhibited different patterns according to the exposed larval stage. Taken together, these findings indicate that tea and its waste affect most key components of Ae. albopictus vectorial capacity and may be useful for dengue control. Reusing tea waste in vector control could also be a practical solution to the problems associated with its pollution.",Pubmed,May 30, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Original research,No,Yes,880,Environmental and vector research,Vector control studies
881,"Brasil, Lancet, 2016",Brasil,"Brasil, P.; Sequeira, P. C.; Freitas, A. D.; Zogbi, H. E.; Calvet, G. A.; de Souza, R. V.; Siqueira, A. M.; de Mendonca, M. C.; Nogueira, R. M.; de Filippis, A. M.; Solomon, T.",Guillain-Barre syndrome associated with Zika virus infection,Lancet,387,10026,1482,2016,2010-present,April 27, 2016,27115821,10.1016/S0140-6736(16)30058-7,2312,English,http://www.ncbi.nlm.nih.gov/pubmed/27115821,"Instituto Nacional de Infectologia Evandro Chagas, Fundacao Oswaldo Cruz, Rio de Janeiro, Brazil. Electronic address: patricia.brasil@ini.fiocruz.br.; Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro, Brazil.; Instituto Nacional de Infectologia Evandro Chagas, Fundacao Oswaldo Cruz, Rio de Janeiro, Brazil.; Institute of Infection and Global Health, University of Liverpool, Liverpool, UK; Health Protection Research Unit in Emerging and Zoonotic Infections, University of Liverpool, Liverpool, UK; Walton Centre NHS Foundation Trust, Liverpool, UK.",Brazil,Americas,United Kingdom,,"Brazil; DNA, Viral/genetics; Female; Guillain-Barre Syndrome/*virology; Humans; Real-Time Polymerase Chain Reaction; Young Adult; Zika Virus/genetics/isolation & purification; Zika Virus Infection/cerebrospinal fluid/*complications/diagnosis",,Pubmed,May 30, 2016,Yes,,Yes,,Scientific (journal) article,Yes,Original research,No,Yes,881,Clinical/epidemiological research,Case report
882,"Akiner, PLoS Negl Trop Dis, 2016",Akiner,"Akiner, M. M.; Demirci, B.; Babuadze, G.; Robert, V.; Schaffner, F.","Spread of the Invasive Mosquitoes Aedes aegypti and Aedes albopictus in the Black Sea Region Increases Risk of Chikungunya, Dengue, and Zika Outbreaks in Europe",PLoS Negl Trop Dis,10,4,e0004664,2016,2010-present,April 27, 2016,27115737,10.1371/journal.pntd.0004664,2286,English,http://www.ncbi.nlm.nih.gov/pubmed/27115737,"Recep Tayyip Erdogan University, Faculty of Arts and Sciences, Department of Biology, Fener, Rize, Turkey.; Kafkas University, Molecular Biology and Genetics Department, Kars, Turkey.; Division of Virology and Molecular Biology, National Centre for Disease Control and Public Health (NCDC), Tbilisi, Georgia.; Research Unit MIVEGEC, Institut de Recherche pour le Developpement, Montpellier, France.; Avia-GIS, Zoersel, Belgium.",,,,,,,Pubmed,May 30, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,882,,
883,"Albrecht, J Miss State Med Assoc, 2016",Albrecht,"Albrecht, S. J.; Nolan, R. L.",Top 10 Facts You Need to Know about Zika Virus,J Miss State Med Assoc,57,1,04. Mai,2016,2010-present,April 27, 2016,27111981,,2356,English,http://www.ncbi.nlm.nih.gov/pubmed/27111981,,,,,,Humans; Zika Virus; *Zika Virus Infection,,Pubmed,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,883,,
884,"Qian, Cell, 2016",Qian,"Qian, X.; Nguyen, H. N.; Song, M. M.; Hadiono, C.; Ogden, S. C.; Hammack, C.; Yao, B.; Hamersky, G. R.; Jacob, F.; Zhong, C.; Yoon, K. J.; Jeang, W.; Lin, L.; Li, Y.; Thakor, J.; Berg, D. A.; Zhang, C.; Kang, E.; Chickering, M.; Nauen, D.; Ho, C. Y.; Wen, Z.; Christian, K. M.; Shi, P. Y.; Maher, B. J.; Wu, H.; Jin, P.; Tang, H.; Song, H.; Ming, G. L.",Brain-Region-Specific Organoids Using Mini-bioreactors for Modeling ZIKV Exposure,Cell,165,5,1238-54,2016,2010-present,April 28, 2016,27118425,10.1016/j.cell.2016.04.032,2561,English,http://www.ncbi.nlm.nih.gov/pubmed/27118425,"Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Biomedical Engineering Graduate Program, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.; Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Graduate Program in Cellular and Molecular Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.; Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Riverhill High School, Clarksville, MD 21029, USA.; Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Byram Hills High School, Armonk, NY 10504, USA.; Department of Biological Science, Florida State University, Tallahassee, FL 32306, USA.; Department of Human Genetics, School of Medicine, Emory University, Atlanta, GA 30322, USA.; Lieber Institute for Brain Development, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.; Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.; Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.; Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Clear Lake High School, Harris, TX 77058, USA.; Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.; Division of Pathology, Children's National Medical Center, George Washington University, Washington, DC 20010, USA; Pathology and Pediatrics, George Washington University, Washington, DC 20010, USA.; Department of Biochemistry and Molecular Biology, Sealy Center for Structural Biology and Molecular Biophysics, University of Texas Medical Branch, Galveston, TX 77555, USA.; Lieber Institute for Brain Development, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.; Department of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA.; Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Graduate Program in Cellular and Molecular Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; The Solomon Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address: shongju1@jhmi.edu.; Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Graduate Program in Cellular and Molecular Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; The Solomon Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address: gming1@jhmi.edu.",United States,Americas,United States,,,"Cerebral organoids, three-dimensional cultures that model organogenesis, provide a new platform to investigate human brain development. High cost, variability, and tissue heterogeneity limit their broad applications. Here, we developed a miniaturized spinning bioreactor (SpinOmega) to generate forebrain-specific organoids from human iPSCs. These organoids recapitulate key features of human cortical development, including progenitor zone organization, neurogenesis, gene expression, and, notably, a distinct human-specific outer radial glia cell layer. We also developed protocols for midbrain and hypothalamic organoids. Finally, we employed the forebrain organoid platform to model Zika virus (ZIKV) exposure. Quantitative analyses revealed preferential, productive infection of neural progenitors with either African or Asian ZIKV strains. ZIKV infection leads to increased cell death and reduced proliferation, resulting in decreased neuronal cell-layer volume resembling microcephaly. Together, our brain-region-specific organoids and SpinOmega provide an accessible and versatile platform for modeling human brain development and disease and for compound testing, including potential ZIKV antiviral drugs.",Pubmed,May 30, 2016,Yes,,Yes,,Scientific (journal) article,Yes,Original research,No,Yes,884,Basic and applied biomedical research,In vitro experiment
885,"PAHO, , 2016",PAHO,PAHO,Epidemiological Update. Zika virus infection - 28 April 2016,,,,,2016,2010-present,April 28, 2016,,,2668,,http://www.paho.org/hq/index.php?option=com_docman&task=doc_view&Itemid=270&gid=34327&lang=en,,United States,Americas,,Public/Government,,,PAHO,May 30, 2016,No,Duplicate of existing record,,,,,,,,,,
886,"Mortimer, Rev Med Virol, 2016",Mortimer,"Mortimer, P. P.",Maternal Zika infection: like rubella but worse,Rev Med Virol,,,,2016,2010-present,April 28, 2016,27119589,10.1002/rmv.1886,2497,English,http://www.ncbi.nlm.nih.gov/pubmed/27119589,pandjmortimer@gmail.com.,,,,,,,Pubmed,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,886,,
887,"Voelker, JAMA, 2016",Voelker,"Voelker, R.",Miami Obstetrician Uses Evidence to Quell Zika Fears,JAMA,315,19,2051-2,2016,2010-present,April 28, 2016,27119524,10.1001/jama.2016.4069,2517,English,http://www.ncbi.nlm.nih.gov/pubmed/27119524,,,,,,"Counseling; Fear; Female; Fetal Diseases/prevention & control; Florida; Humans; Microcephaly/diagnosis/virology; Obstetrics; Patient Care Team/organization & administration; *Patient Education as Topic; Pregnancy; Pregnancy Complications, Infectious/*prevention & control/psychology/virology; Travel; Zika Virus Infection/*prevention & control/psychology/transmission",,Pubmed,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,News item or lay press,,,No,Yes,887,,
888,"InVS, Point Epidemiologique CIRE Antilles Guyane, 2016",InVS,InVS,Point epidemio: Emergence du virus zika aux Antilles Guyane : Situation epidemiologique - 28 avril 2016,Point Epidemiologique CIRE Antilles Guyane,16,,,2016,2010-present,April 28, 2016,,,2203,French,http://www.invs.sante.fr/fr/Publications-et-outils/Points-epidemiologiques/Tous-les-numeros/Antilles-Guyane/2016/Situation-epidemiologique-du-virus-Zika-aux-Antilles-Guyane.-Point-au-28-avril-2016,,France,Europe,,Public/Government,,,Institute de veille sanitaire,May 30, 2016,Yes,,No,"Zika, indirect evidence or other topic",Surveillance report or data,,,No,Yes,888,Clinical/epidemiological research,Ecological study/outbreak report
889,"Guo, Cell Biosci, 2016",Guo,"Guo, J.",Studies using IPS cells support a possible link between ZIKA and microcephaly,Cell Biosci,6,,28,2016,2010-present,April 28, 2016,27119012,10.1186/s13578-016-0096-4,2445,English,http://www.ncbi.nlm.nih.gov/pubmed/27119012,"National Center for Biodefense and Infectious Diseases, George Mason University, Manassas, VA USA.",,,,,Human neural progenitor cells; Microcephaly; Zika virus,"There is a suspected link between Brazilian babies born with microcephaly and Zika virus (ZIKV) infection. However, little is know about the brain cell targets and the mechanisms that Zika virus may cause microcephaly. A recent report demonstrated that Zika virus infection increases cell death and dysregulates cell-cycle, resulting in attenuated human neural progenitor cells growth. This study fills a major gap and serves as an entry point to establish a mechanistic link between Zika infection and microcephaly.",Pubmed,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,889,,
890,"WHO, , 2016",WHO,WHO,"Zika situation report. Zika virus, Microcephaly and Guillain-Barré syndrome - 28 April 2016",,,,,2016,2010-present,April 28, 2016,,,2735,,http://www.who.int/emergencies/zika-virus/situation-report/28-april-2016/en/,,Switzerland,Europe,,Public/Government,,,WHO,May 30, 2016,Yes,,No,"Zika, indirect evidence or other topic",Surveillance report or data,,,No,Yes,890,Clinical/epidemiological research,Ecological study/outbreak report
891,"Thiery, Intensive Care Med, 2016",Thiery,"Thiery, G.; Valentino, R.; Meddhaoui, H.",Zika virus-associated Guillain-Barre syndrome: a warning for critical care physicians,Intensive Care Med,,,,2016,2010-present,April 28, 2016,27118575,10.1007/s00134-016-4364-x,2544,English,http://www.ncbi.nlm.nih.gov/pubmed/27118575,"Intensive Care Unit, University Hospital of Pointe-a-Pitre/Abymes, Guadeloupe, France. guillaume.thiery.bih@gmail.com.; University of French West Indies/Universite des Antilles, Guadeloupe, France. guillaume.thiery.bih@gmail.com.; Intensive Care Unit, University Hospital of Fort de France, Martinique, France.",,,,,,,Pubmed,May 30, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,891,,
892,"ECDC, , 2016",ECDC,ECDC,Epidemiological update. Outbreaks of Zika virus and complication potentially linked to the Zika virus infection - 29 April 2016,,,,,2016,2010-present,April 29, 2016,,,2187,,http://ecdc.europa.eu/en/press/news/_layouts/forms/News_DispForm.aspx?ID=1417&List=8db7286c-fe2d-476c-9133-18ff4cb1b568&Source=http%3A%2F%2Fecdc.europa.eu%2Fen%2Fhealthtopics%2Fzika_virus_infection%2FPages%2Fepidemiological-updates.aspx,,Sweden,Europe,,Public/Government,,,ECDC,May 30, 2016,Yes,,No,"Zika, indirect evidence or other topic",Surveillance report or data,,,No,Yes,892,Clinical/epidemiological research,Ecological study/outbreak report
893,"Rodriguez-Morales, Bull World Health Organ, 2016",Rodriguez-Morales,"Rodriguez-Morales, Alfonso J.; Haque, Ubydul; Ball, Jacob D.; García-Loaiza, Carlos Julian; Galindo-Marquez, Maria Leonor; Sabogal-Roman, Juan Alejandro; Marin-Loaiza, Santiago; Ayala, Andrés Felipe; Lozada-Riascos, Carlos O.; Diaz-Quijano, Fredi A.; Alvarado-Socarras, Jorge L.",Spatial distribution of Zika virus infection in northeastern Colombia,Bull World Health Organ,published online 29.04.2016 (submitted 28.04.2016),,,2016,2010-present,April 29, 2016,,10.2471/blt.16.176529,2738,,http://www.who.int/bulletin/online_first/16-176529.pdf,,,,,,,,WHO Zika open,May 30, 2016,Yes,,No,"Zika, not relevant to causality framework",Scientific (journal) article,No,Original research,No,Yes,893,Clinical/epidemiological research,Modelling study
894,"Roze, Eurosurveillance, 2016",Roze,"Roze, B.; Najioullah, F.; Signate, A.; Apetse, K.; Brouste, Y.; Gourgoudou, S.; Fagour, L.; Abel, S.; Hochedez, P.; Cesaire, R.; Cabie, A.; Neuro-Zika Working Group of, Martinique","Zika virus detection in cerebrospinal fluid from two patients with encephalopathy, Martinique, February 2016",Eurosurveillance,21,16,,2016,2010-present,April 29, 2016,27123558,10.2807/1560-7917.ES.2016.21.16.30205,2487,English,http://www.ncbi.nlm.nih.gov/pubmed/27123558,"Infectious and Tropical Diseases Department, University Hospital of Martinique, Fort-de-France, France.",France,Europe,France,,Arthropod borne virus; Encephalopathy; Flavivirus; Zika virus infection; confusion; seizure,"We report two cases of encephalopathy (one with seizures, one with electroencephalogram changes) in patients with Zika virus infection. The cases occurred on Martinique in February 2016, during the Zika virus outbreak. Awareness of the various neurological complications of Zika virus infection is needed for patients living in areas affected by Zika virus infections or for travellers to these areas.",Pubmed,May 30, 2016,Yes,,No,"Zika, indirect evidence or other topic",Scientific (journal) article,Yes,Original research,No,Yes,894,Clinical/epidemiological research,Case series
895,"Ramos da Silva, J Med Virol, 2016",Ramos da Silva,"Ramos da Silva, S.; Gao, S. J.","Zika virus: An update on epidemiology, pathology, molecular biology, and animal model",J Med Virol,88,8,1291-6,2016,2010-present,April 29, 2016,27124623,10.1002/jmv.24563,2511,English,http://www.ncbi.nlm.nih.gov/pubmed/27124623,"Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, California.",,,,,Zika virus; animal model; epidemiology; pathology; transmission,"Zika virus (ZIKV) was first described in 1947, and became a health emergency problem in 2016 when its association with fetal microcephaly cases was confirmed by Centers for Disease Control and Prevention (CDC) in the United States. To date, ZIKV infection has been documented in 66 countries. ZIKV is recognized as a neurotropic virus and numerous diseases manifested in multiple neurological disorders have been described, mainly in countries that have been exposed to ZIKV after the 2007 outbreak in the Federated States of Micronesia. The most dramatic consequence of ZIKV infection documented is the abrupt increase in fetal microcephaly cases in Brazil. Here, we present an update of the published research progress in the past few months. J. Med. Virol. 88:1291-1296, 2016. (c) 2016 Wiley Periodicals, Inc.",Pubmed,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Yes,Review,No,Yes,895,Clinical/epidemiological research,Epidemiological/clinical review
896,"De Smet, J Clin Virol, 2016",De Smet,"De Smet, B.; Van den Bossche, D.; van de Werve, C.; Mairesse, J.; Schmidt-Chanasit, J.; Michiels, J.; Arien, K. K.; Van Esbroeck, M.; Cnops, L.","Confirmed Zika virus infection in a Belgian traveler returning from Guatemala, and the diagnostic challenges of imported cases into Europe",J Clin Virol,80,,08. Nov,2016,2010-present,April 30, 2016,27128355,10.1016/j.jcv.2016.04.009,2347,English,http://www.ncbi.nlm.nih.gov/pubmed/27128355,"National Reference Center for Arboviruses, Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.; Travel Clinic, Clinique Saint-Pierre, Ottignies, Belgium.; Biologie Clinique, Clinique Saint-Pierre, Ottignies, Belgium.; WHO Collaborating Centre for Arbovirus and Haemorrhagic Fever Reference and Research, National Reference Centre for Tropical Infectious Diseases, Bernhard- Nocht, Institute for Tropical Medicine, Hamburg, Germany; German Centre for Infection Research (DZIF), partner site Hamburg-Lubeck-Borstel, Hamburg, Germany.; Unit of Virology, Department of Biomedical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.; National Reference Center for Arboviruses, Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium. Electronic address: lcnops@itg.be.",,,,,Europe; Import; Real-time RT-PCR; Zika virus,"We report the first laboratory-confirmed Zika virus (ZIKV) infection in a Belgian traveler after a three week holiday in Guatemala, December 2015. This case along with other imported cases into Europe emphases once again the need for accurate diagnostic tools for this rapidly emerging virus. The challenge is to diagnose patients in the acute phase, which appears short, as serological testing is complicated by cross-reactivity, vaccination status and scarce availability of specific ZIKV tests.",Pubmed,May 30, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Original research,No,Yes,896,Clinical/epidemiological research,Case report
897,"Huzly, Eurosurveillance, 2016",Huzly,"Huzly, D.; Hanselmann, I.; Schmidt-Chanasit, J.; Panning, M.",High specificity of a novel Zika virus ELISA in European patients after exposure to different flaviviruses,Eurosurveillance,21,16,,2016,2010-present,April 30, 2016,27126052,10.2807/1560-7917.ES.2016.21.16.30203,2451,English,http://www.ncbi.nlm.nih.gov/pubmed/27126052,"Institute for Virology, Medical Center - University of Freiburg, Freiburg, Germany.",,,,,Elisa; European travellers; Zika virus; cross-reactivity; flavivirus; specificity,"The current Zika virus (ZIKV) epidemic in the Americas caused an increase in diagnostic requests in European countries. Here we demonstrate high specificity of the Euroimmun anti-ZIKV IgG and IgM ELISA tests using putative cross-reacting sera of European patients with antibodies against tick-borne encephalitis virus, dengue virus, yellow fever virus and hepatitis C virus. This test may aid in counselling European travellers returning from regions where ZIKV is endemic.",Pubmed,May 30, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Original research,No,Yes,897,Clinical/epidemiological research,Diagnostic study
898,", Drug Ther Bull, 2016",,,DTB Select: 5 | May 2016,Drug Ther Bull,54,5,50-3,2016,2010-present,May 1, 2016,27130673,10.1136/dtb.2016.5.0398,2361,English,http://www.ncbi.nlm.nih.gov/pubmed/27130673,,,,,,,Hyperkalaemia with spironolactone Testosterone treatment in older men and sexual function OTC artificial tear drops for dry eye Decline in age-specific incidence of dementia Diabetes and blood pressure targets Zika virus and travel advice for pregnant women Minimising the risk of DKA with SGLT2 inhibitors NSAIDs for chronic low back pain Review of online point-of-care information.,Pubmed,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,898,,
899,"Olagnier, J Mol Biol, 2016",Olagnier,"Olagnier, D.; Amatore, D.; Castiello, L.; Ferrari, M.; Palermo, E.; Diamond, M. S.; Palamara, A. T.; Hiscott, J.",Dengue Virus Immunopathogenesis: Lessons Applicable to the Emergence of Zika Virus,J Mol Biol,,,,2016,2010-present,May 1, 2016,27130436,10.1016/j.jmb.2016.04.024,2549,English,http://www.ncbi.nlm.nih.gov/pubmed/27130436,"Lady Davis Institute, Jewish General Hospital, McGill University Montreal, Canada.; Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.; Istituto Pasteur-Fondazione Cenci Bolognetti, Rome, Italy.; Departments of Medicine, Molecular Microbiology, Pathology & Immunology, Washington University at St. Louis, St. Louis, MO, USA.; Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy; Istituto Pasteur-Fondazione Cenci Bolognetti, Rome, Italy.; Istituto Pasteur-Fondazione Cenci Bolognetti, Rome, Italy. Electronic address: john.hiscott@istitutopasteur.it.",,,,,Zika; dengue; innate immunity; oxidative stress; pathogenesis,"Dengue is the leading mosquito-transmitted viral infection in the world. There are more than 390 million new infections annually; while the majority of infected individuals are asymptomatic or develop a self-limited dengue fever, up to 1 million clinical cases develop severe manifestations, including dengue hemorrhagic fever and shock syndrome, resulting in ~25,000 deaths annually, mainly in children. Gaps in our understanding of the mechanisms that contribute to dengue infection and immunopathogenesis have hampered the development of vaccines and antiviral agents. Some of these limitations are highlighted by the explosive re-emergence of another arthropod-borne flavivirus-Zika virus-spread by the same vector, the Aedes aegypti mosquito, that also carries dengue, yellow fever and chikungunya viruses. This review will discuss the early virus-host interactions in dengue infection, with emphasis on the interrelationship between oxidative stress and innate immune pathways, and will provide insight as to how lessons learned from dengue research may expedite therapeutic strategies for Zika virus.",Pubmed,May 30, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Review,No,Yes,899,Basic and applied biomedical research,Basic research review
900,"Shen, Virol Sin, 2016",Shen,"Shen, S.; Shi, J.; Wang, J.; Tang, S.; Wang, H.; Hu, Z.; Deng, F.",Phylogenetic analysis revealed the central roles of two African countries in the evolution and worldwide spread of Zika virus,Virol Sin,31,2,118-30,2016,2010-present,May 1, 2016,27129451,10.1007/s12250-016-3774-9,2533,English,http://www.ncbi.nlm.nih.gov/pubmed/27129451,"State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, 430071, China.; State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, 430071, China. df@wh.iov.cn.",,,,,Flaviviridae; Zika virus (ZIKV); lineages; migration; phylogenetic analysis; recombination,"Recent outbreaks of Zika virus (ZIKV) infections in Oceania's islands and the Americas were characterized by high numbers of cases and the spread of the virus to new areas. To better understand the origin of ZIKV, its epidemic history was reviewed. Although the available records and information are limited, two major genetic lineages of ZIKV were identified in previous studies. However, in this study, three lineages were identified based on a phylogenetic analysis of all virus sequences from GenBank, including those of the envelope protein (E) and non-structural protein 5 (NS5) coding regions. The spatial and temporal distributions of the three identified ZIKV lineages and the recombination events and mechanisms underlying their divergence and evolution were further elaborated. The potential migration pathway of ZIKV was also characterized. Our findings revealed the central roles of two African countries, Senegal and Cote d'Ivoire, in ZIKV evolution and genotypic divergence. Furthermore, our results suggested that the outbreaks in Asia and the Pacific islands originated from Africa. The results provide insights into the geographic origins of ZIKV outbreaks and the spread of the virus, and also contribute to a better understanding of ZIKV evolution, which is important for the prevention and control of ZIKV infections.",Pubmed,May 30, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Unknown/unclear,Original research,No,Yes,900,Basic and applied biomedical research,Sequence analysis and phylogenetics
901,"Wang, Virol Sin, 2016",Wang,"Wang, Z.; Wang, P.; An, J.",Zika virus and Zika fever,Virol Sin,31,2,103-9,2016,2010-present,May 1, 2016,27129450,10.1007/s12250-016-3780-y,2528,English,http://www.ncbi.nlm.nih.gov/pubmed/27129450,"Department of Microbiology, School of Basic Medical Sciences, Chinese Capital Medical University, Beijing, 100069, China.; Department of Microbiology, School of Basic Medical Sciences, Chinese Capital Medical University, Beijing, 100069, China. pgwang@ccmu.edu.cn.; Department of Microbiology, School of Basic Medical Sciences, Chinese Capital Medical University, Beijing, 100069, China. anjing@ccmu.edu.cn.",,,,,Zika fever; Zika host interaction; Zika virus; microcephaly; neuronal disorder,"An emerging mosquito-borne arbovirus named Zika virus (ZIKV), of the family Flaviviridae and genus Flavivirus, is becoming a global health threat. ZIKV infection was long neglected due to its sporadic nature and mild symptoms. However, recently, with its rapid spread from Asia to the Americas, affecting more than 30 countries, accumulating evidences have demonstrated a close association between infant microcephaly and Zika infection in pregnant women. Here, we reviewed the virological, epidemiological, and clinical essentials of ZIKV infection.",Pubmed,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Unknown/unclear,Review,No,Yes,901,Clinical/epidemiological research,Epidemiological/clinical review
902,"Colt, Bull World Health Organ, 2016",Colt,"Colt, Susannah; Garcia-Casal, Maria N.; Peña-Rosas, Juan Pablo; Finkelstein, Julia L.; Rayco-Solon, Pura; Prinzo, Zita Weise; Mehta, Saurabh",Transmission of Zika virus through breast milk and other breastfeeding-related bodily-fluids: a systematic review,Bull World Health Organ,published online 02.05.2016 (submitted 02.05.2016),,,2016,2010-present,May 2, 2016,,10.2471/blt.16.176677,2740,,http://www.who.int/bulletin/online_first/16-176677.pdf,,,,,,,,WHO Zika open,May 30, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,No,Review,No,Yes,902,Clinical/epidemiological research,Epidemiological/clinical review
903,"Attar, Nat Rev Microbiol, 2016",Attar,"Attar, N.",Epidemiology: Which regions are vulnerable to Zika virus?,Nat Rev Microbiol,14,6,335,2016,2010-present,May 4, 2016,27140691,10.1038/nrmicro.2016.70,2353,English,http://www.ncbi.nlm.nih.gov/pubmed/27140691,,,,,,,,Pubmed,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,903,,
904,"Wiwanitkit, Childs Nerv Syst, 2016",Wiwanitkit,"Wiwanitkit, V.",Neonatal neuroradiological aspects in Zika virus infection,Childs Nerv Syst,,,,2016,2010-present,May 4, 2016,27138556,10.1007/s00381-016-3102-6,2604,English,http://www.ncbi.nlm.nih.gov/pubmed/27138556,"Surindra Rajabhat University, Surin, Thailand. wviroj@yahoo.com.; Bangkhae, Bangkok, Thailand. wviroj@yahoo.com.",,,,,,,Pubmed,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,904,,
905,"InVS, Point Epidemiologique CIRE Antilles Guyane, 2016",InVS,InVS,Point epidemio: Emergence du virus zika aux Antilles Guyane : Situation epidemiologique - 04 mai 2016,Point Epidemiologique CIRE Antilles Guyane,17,,,2016,2010-present,May 4, 2016,,,2221,French,http://www.invs.sante.fr/fr/Publications-et-outils/Points-epidemiologiques/Tous-les-numeros/Antilles-Guyane/2016/Situation-epidemiologique-du-virus-Zika-aux-Antilles-Guyane.-Point-au-4-mai-2016,,France,Europe,,Public/Government,,,Institute de veille sanitaire,May 30, 2016,Yes,,No,"Zika, indirect evidence or other topic",Surveillance report or data,,,No,Yes,905,Clinical/epidemiological research,Ecological study/outbreak report
906,"Brault, Am J Trop Med Hyg, 2016",Brault,"Brault, A. C.; Bowen, R. A.",The Development of Small Animal Models for Zika Virus Vaccine Efficacy Testing and Pathological Assessment,Am J Trop Med Hyg,94,6,1187-8,2016,2010-present,May 4, 2016,27139439,10.4269/ajtmh.16-0277,2290,English,http://www.ncbi.nlm.nih.gov/pubmed/27139439,"Division of Vector-Borne Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado; Department of Biomedical Sciences, Colorado State University, Fort Collins, Colorado abrault@cdc.gov.; Division of Vector-Borne Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado; Department of Biomedical Sciences, Colorado State University, Fort Collins, Colorado.",,,,,,Zika virus (ZIKV) is a mosquito-borne flavivirus serologically grouped within the in the Zika Forest of Uganda in 1947. Subsequent genetic analyses have demonstrated the presence of two distinctive African and Asian viral genotypes. Federated States of Micronesia (with 49 laboratory confirmed cases documented). disease being identified in Brazil in early 2015. Although the majority of human recent identification of an association of ZIKV infection during pregnancy with development of Guillain-Barre syndrome resulted in the World Health of the pathological mechanisms that result in human disease after infection with this virus.,Pubmed,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,906,,
907,"Hennessey, Am J Trop Med Hyg, 2016",Hennessey,"Hennessey, M. J.; Fischer, M.; Panella, A.; Kosoy, O.; Laven, J.; Lanciotti, R. S.; Staples, J. E.","Zika Virus Disease in Travelers Returning to the United States, 2010-2014",Am J Trop Med Hyg,,,,2016,2010-present,May 4, 2016,27139440,10.4269/ajtmh.16-0049,2460,English,http://www.ncbi.nlm.nih.gov/pubmed/27139440,"Arboviral Diseases Branch, Centers for Disease Control and Prevention (CDC), Fort Collins, Colorado.; Arboviral Diseases Branch, Centers for Disease Control and Prevention (CDC), Fort Collins, Colorado estaples@cdc.gov.",,,,,,"Zika virus is an emerging mosquito-borne flavivirus that typically causes a mild febrile illness with rash, arthralgia, or conjunctivitis. Zika virus has recently caused large outbreaks of disease in southeast Asia, Pacific Ocean Islands, and the Americas. We identified all positive Zika virus test results performed at U.S. Centers for Disease Control and Prevention from 2010 to 2014. For persons with test results indicating a recent infection with Zika virus, we collected information on demographics, travel history, and clinical features. Eleven Zika virus disease cases were identified among travelers returning to the United States. The median age of cases was 50 years (range: 29-74 years) and six (55%) were male. Nine (82%) cases had their illness onset from January to April. All cases reported a travel history to islands in the Pacific Ocean during the days preceding illness onset, and all cases were potentially viremic while in the United States. Public health prevention messages about decreasing mosquito exposure, preventing sexual exposure, and preventing infection in pregnant women should be targeted to individuals traveling to or living in areas with Zika virus activity. Health-care providers and public health officials should be educated about the recognition, diagnosis, and prevention of Zika virus disease.",Pubmed,May 30, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Original research,No,Yes,907,Clinical/epidemiological research,Case series
908,"Salinas, Med Sci (Paris), 2016",Salinas,"Salinas, S.; Foulongne, V.; Loustalot, F.; Fournier-Wirth, C.; Moles, J. P.; Briant, L.; Nagot, N.; Van de Perre, P.; Simonin, Y.","[Zika virus, an emerging threat]",Med Sci (Paris),32,4,378-86,2016,2010-present,May 4, 2016,27137695,10.1051/medsci/20163204016,2483,French,http://www.ncbi.nlm.nih.gov/pubmed/27137695,"UMR 1058, Inserm/universite de Montpellier/Etablissement francais du sang, Pathogenesis and control of chronic infections, Inserm, 60, rue de Navacelles, 34394 Montpellier Cedex 5, France.; UMR 1058, Inserm/universite de Montpellier/Etablissement francais du sang, Pathogenesis and control of chronic infections, Inserm, 60, rue de Navacelles, 34394 Montpellier Cedex 5, France - Centre hospitalier universitaire de Montpellier, departement de bacteriologie-virologie, Montpellier, France.; UMR 1058, Inserm/universite de Montpellier/Etablissement francais du sang, Pathogenesis and control of chronic infections, Inserm, 60, rue de Navacelles, 34394 Montpellier Cedex 5, France - Etablissement francais du sang, parc Euromedecine, 34184 Montpellier Cedex 4, France.; CPBS, FRE3689, CNRS-universite de Montpellier, 1919, route de Mende, 34293 Montpellier Cedex 5, France.; UMR 1058, Inserm/universite de Montpellier/Etablissement francais du sang, Pathogenesis and control of chronic infections, Inserm, 60, rue de Navacelles, 34394 Montpellier Cedex 5, France - Universite de Montpellier, 4, boulevard Henri IV, 34967 Montpellier Cedex 2, France.",,,,,,"Zika virus, discovered in 1947, is particularly publicized because of its involvement in a major epidemic that began in 2015 and which epicenter is located in Latin America, mainly in Brazil. In the majority of cases (70-80 %) the infection is asymptomatic, however in some patients, moderate fever, skin rash, conjunctivitis and myalgia may occur. More alarming, neurological complications are reported, in particular cases of microcephaly probably resulting from the infection of women in the first or second trimester of pregnancy. Moreover, Guillain-Barre syndromes have also been identified in patients whose infection was confirmed. The extent of the current outbreak reveals the very primitive state of knowledge about the pathophysiology of this virus. Thus, a global effort is being undertaken in order to quickly characterize the molecular interaction of the virus with human cells, but also to develop specific diagnostic assays and vaccinal approaches.",Pubmed,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,908,,
909,"PAHO, Epidemiological update. Zika virus infection - 28 April 2016, 2016",PAHO,PAHO,Epidemiological update. Zika virus infection - 28 April 2016,,Epidemiological update. Zika virus infection - 28 April 2016,,,2016,2010-present,May 5, 2016,,,2669,,http://www.paho.org/hq/index.php?option=com_docman&task=doc_view&Itemid=270&gid=34455&lang=en,,United States,Americas,,Public/Government,,,PAHO,May 30, 2016,Yes,,Yes,,Surveillance report or data,,,No,Yes,909,Clinical/epidemiological research,Ecological study/outbreak report
910,"Slavov, Braz J Med Biol Res, 2016",Slavov,"Slavov, S. N.; Otaguiri, K. K.; Kashima, S.; Covas, D. T.",Overview of Zika virus (ZIKV) infection in regards to the Brazilian epidemic,Braz J Med Biol Res,49,5,e5420,2016,2010-present,May 5, 2016,27143174,10.1590/1414-431X20165420,2486,English,http://www.ncbi.nlm.nih.gov/pubmed/27143174,"Hemocentro de Ribeirao Preto, Faculdade de Medicina de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto, SP, Brasil.",,,,,,"Zika virus (ZIKV), a mosquito-borne flavivirus, belongs to the Flaviviridae family, genus Flavivirus. ZIKV was initially isolated in 1947 from a sentinel monkey in the Zika forest, Uganda. Little clinical importance was attributed to ZIKV, once only few symptomatic cases were reported in some African and Southeast Asiatic countries. This situation changed in 2007, when a large outbreak was registered on the Yap Island, Micronesia, caused by the Asian ZIKV lineage. Between 2013 and 2014, ZIKV spread explosively and caused many outbreaks in different islands of the Southern Pacific Ocean and in 2015 autochthonous transmission was reported in Brazil. Currently, Brazil is the country with the highest number of ZIKV-positive cases in Latin America. Moreover, for the first time after the discovery of ZIKV, the Brazilian scientists are studying the possibility for the virus to cause severe congenital infection related to microcephaly and serious birth defects due to the time-spatial coincidence of the alarming increase of newborns with microcephaly and the Brazilian ZIKV epidemic. The present review summarizes recent information for ZIKV epidemiology, clinical picture, transmission, diagnosis and the consequences of this emerging virus in Brazil.",Pubmed,May 30, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Yes,Review,No,Yes,910,Clinical/epidemiological research,Epidemiological/clinical review
911,"Carvalho, Cad Saude Publica, 2016",Carvalho,"Carvalho, M. S.",The Zika epidemic in Cadernos de Saude Publica / Reports in Public Health,Cad Saude Publica,32,4,e00010416,2016,2010-present,May 5, 2016,27143305,10.1590/0102-311XED010416,2359,English,http://www.ncbi.nlm.nih.gov/pubmed/27143305,,,,,,,,Pubmed,May 30, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,911,,
912,"Paploski, Emerg Infect Dis, 2016",Paploski,"Paploski, I. A.; Prates, A. P.; Cardoso, C. W.; Kikuti, M.; Silva, M. M.; Waller, L. A.; Reis, M. G.; Kitron, U.; Ribeiro, G. S.","Time Lags between Exanthematous Illness Attributed to Zika Virus, Guillain-Barre Syndrome, and Microcephaly, Salvador, Brazil",Emerg Infect Dis,22,8,,2016,2010-present,May 5, 2016,27144515,10.3201/eid2208.160496,2543,English,http://www.ncbi.nlm.nih.gov/pubmed/27144515,,Brazil,Americas,Brazil,Public/Government,Brazil; Guillain-Barre syndrome; Salvador; Zika virus; epidemiology; exanthematous illness; microcephaly; outbreaks; pregnant women; time lags; viruses,"Zika virus infection emerged as a public health emergency after increasing evidence for its association with neurologic disorders and congenital malformations. In Salvador, Brazil, outbreaks of acute exanthematous illness (AEI) attributed to Zika virus, Guillain-Barre syndrome (GBS), and microcephaly occurred in 2015. We investigated temporal correlations and time lags between these outbreaks to identify a common link between them by using epidemic curves and time series cross-correlations. Number of GBS cases peaked after a lag of 5-9 weeks from the AEI peak. Number of suspected cases of microcephaly peaked after a lag of 30-33 weeks from the AEI peak, which corresponded to time of potential infections of pregnant mothers during the first trimester. These findings support the association of GBS and microcephaly with Zika virus infection and provide evidence for a temporal relationship between timing of arboviral infection of pregnant women during the first trimester and birth outcome.",Pubmed,May 30, 2016,Yes,,Yes,,Scientific (journal) article,Yes,Original research,Yes,Yes,912,Clinical/epidemiological research,Ecological study/outbreak report
913,"WHO, , 2016",WHO,WHO,"Zika situation report. Zika virus, Microcephaly and Guillain-Barré syndrome - 05 May 2016",,,,,2016,2010-present,May 5, 2016,,,2746,,http://www.who.int/emergencies/zika-virus/situation-report/5-may-2016/en/,,Switzerland,Europe,,Public/Government,,,WHO,May 30, 2016,Yes,,No,"Zika, indirect evidence or other topic",Surveillance report or data,,,No,Yes,913,Clinical/epidemiological research,Ecological study/outbreak report
914,"Noronha, Mem Inst Oswaldo Cruz, 2016",Noronha,"Noronha, Ld; Zanluca, C.; Azevedo, M. L.; Luz, K. G.; Santos, C. N.",Zika virus damages the human placental barrier and presents marked fetal neurotropism,Mem Inst Oswaldo Cruz,111,5,287-93,2016,2010-present,May 5, 2016,27143490,10.1590/0074-02760160085,2502,English,http://www.ncbi.nlm.nih.gov/pubmed/27143490,"Pontificia Universidade Catolica do Parana, Curitiba, PR, Brasil.; Laboratorio de Virologia Molecular, Instituto Carlos Chagas, Fundacao Oswaldo Cruz, Curitiba, PR, Brasil.; Instituto de Medicina Tropical, Universidade Federal do Rio Grande do Norte, Natal, RN, Brasil.",Brazil,Americas,Brazil,,,"An unusually high incidence of microcephaly in newborns has recently been observed in Brazil. There is a temporal association between the increase in cases of microcephaly and the Zika virus (ZIKV) epidemic. Viral RNA has been detected in amniotic fluid samples, placental tissues and newborn and fetal brain tissues. However, much remains to be determined concerning the association between ZIKV infection and fetal malformations. In this study, we provide evidence of the transplacental transmission of ZIKV through the detection of viral proteins and viral RNA in placental tissue samples from expectant mothers infected at different stages of gestation. We observed chronic placentitis (TORCH type) with viral protein detection by immunohistochemistry in Hofbauer cells and some histiocytes in the intervillous spaces. We also demonstrated the neurotropism of the virus via the detection of viral proteins in glial cells and in some endothelial cells and the observation of scattered foci of microcalcifications in the brain tissues. Lesions were mainly located in the white matter. ZIKV RNA was also detected in these tissues by real-time-polymerase chain reaction. We believe that these findings will contribute to the body of knowledge of the mechanisms of ZIKV transmission, interactions between the virus and host cells and viral tropism.",Pubmed,May 30, 2016,Yes,,Yes,,Scientific (journal) article,Yes,Original research,No,Yes,914,Clinical/epidemiological research,Case series
915,"de Fatima Vasco Aragao, BMJ, 2016",de Fatima Vasco Aragao,"de Fatima Vasco Aragao, M.",Zika virus study in The BMJ was different from the one reported in the New England Journal of Medicine,BMJ,353,,i2444,2016,2010-present,May 5, 2016,27142055,10.1136/bmj.i2444,2352,English,http://www.ncbi.nlm.nih.gov/pubmed/27142055,"Centro Diagnostico Multimagem, Rua Frei Matias Tevis, 194, Ilha do Leite Recife Pernambuco 52010-450, Brazil; Medical School, Mauricio de Nassau University, Recife, Pernambuco, Brazil.",,,,,,,Pubmed,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,No,Comment/Editorial/Perspective/Letter,No,Yes,915,,
916,"Zheng, Zhonghua Er Ke Za Zhi, 2016",Zheng,"Zheng, C. G.; Xu, Y.; Jiang, H. Q.; Yin, Y. X.; Zhang, J. H.; Zhu, W. J.; Liang, X. J.; Chen, M. X.; Ye, J. W.; Tan, L. M.; Luo, D.; Gong, S. T.",[Clinical analysis of two cases of imported children Zika virus infection in China],Zhonghua Er Ke Za Zhi,54,5,375-8,2016,2010-present,May 5, 2016,27143081,10.3760/cma.j.issn.0578-1310.2016.05.013,2597,Other,http://www.ncbi.nlm.nih.gov/pubmed/27143081,"Department of Infectious Diseases, Enping People's Hospital of Gunagdong, Enping 529400, China.; Department of Infectious Diseases, Guangzhou Women and Children's Medical Center, Guangzhou 510120, China.",,,,,,"OBJECTIVE: To analyze the clinical characteristics, outcome and diagnosis of two cases of imported children Zika virus infection in China. METHOD: A retrospective analysis was performed on clinical characteristics, treatment and outcome of two cases of imported children with Zika virus infection in February 2016 in Enping People's Hospital of Guangdong. RESULT: Two cases of children with imported Zika virus infection resided in an affected area of Venezuela, 8-year-old girl and her 6 year-old brother. The main findings on physical examination included the following manifestations: fever, rash, and conjunctivitis. The rash was first limited to the abdomen, but extended to the torso, neck and face, and faded after 3-4 d. The total number of white blood cells was not high and liver function was normal. The diagnosis of two cases of Zika virus infection was confirmed by the expert group of Guangdong Provincial Center for Disease Control and Prevention, according to the epidemiological history, clinical manifestations and Zika virus nucleic acid detection results.Treatment of Zika virus infection involves supportive care. Two Zika virus infection children had a relatively benign outcome. CONCLUSION: At present, Zika virus infection in children is an imported disease in China. No specific therapy is available for this disease. Information on long-term outcomes among infants and children with Zika virus disease is limited, routine pediatric care is advised for these infants and children.",Pubmed,May 30, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Unknown/unclear,Original research,No,Yes,916,Clinical/epidemiological research,Case series
917,"Saiz, Front Microbiol, 2016",Saiz,"Saiz, J. C.; Vazquez-Calvo, A.; Blazquez, A. B.; Merino-Ramos, T.; Escribano-Romero, E.; Martin-Acebes, M. A.",Zika Virus: the Latest Newcomer,Front Microbiol,7,,496,2016,2010-present,May 6, 2016,27148186,10.3389/fmicb.2016.00496,2531,English,http://www.ncbi.nlm.nih.gov/pubmed/27148186,"Department of Biotechnology, Instituto Nacional de Investigacion y Tecnologia Agraria y Alimentaria Madrid, Spain.",,,,,Zika; flavivirus; microcephaly; outbreak; zoonosis,"Since the beginning of this century, humanity has been facing a new emerging, or re-emerging, virus threat almost every year: West Nile, Influenza A, avian flu, dengue, Chikungunya, SARS, MERS, Ebola, and now Zika, the latest newcomer. Zika virus (ZIKV), a flavivirus transmitted by Aedes mosquitoes, was identified in 1947 in a sentinel monkey in Uganda, and later on in humans in Nigeria. The virus was mainly confined to the African continent until it was detected in south-east Asia the 1980's, then in the Micronesia in 2007 and, more recently in the Americas in 2014, where it has displayed an explosive spread, as advised by the World Health Organization, which resulted in the infection of hundreds of thousands of people. ZIKV infection was characterized by causing a mild disease presented with fever, headache, rash, arthralgia, and conjunctivitis, with exceptional reports of an association with Guillain-Barre syndrome (GBS) and microcephaly. However, since the end of 2015, an increase in the number of GBS associated cases and an astonishing number of microcephaly in fetus and new-borns in Brazil have been related to ZIKV infection, raising serious worldwide public health concerns. Clarifying such worrisome relationships is, thus, a current unavoidable goal. Here, we extensively review what is currently known about ZIKV, from molecular biology, transmission routes, ecology, and epidemiology, to clinical manifestations, pathogenesis, diagnosis, prophylaxis, and public health.",Pubmed,May 30, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Yes,Review,No,Yes,917,Clinical/epidemiological research,Epidemiological/clinical review
918,"Nandy, Int J Mol Sci, 2016",Nandy,"Nandy, A.; Basak, S. C.",A Brief Review of Computer-Assisted Approaches to Rational Design of Peptide Vaccines,Int J Mol Sci,17,5,,2016,2010-present,May 7, 2016,27153063,10.3390/ijms17050666,2534,English,http://www.ncbi.nlm.nih.gov/pubmed/27153063,"Centre for Interdisciplinary Research and Education, Jodhpur Park, Kolkata 700068, India. anandy43@yahoo.com.; Natural Resources Research Institute and Department of Chemistry & Biochemistry, University of Minnesota Duluth, Duluth, MN 55811, USA. sbasak@nrri.umn.edu.",,,,,Zika virus; alignment-free analysis; chikungunya; computer assisted vaccine development; dengue; epitopes; peptide vaccines; rational peptide vaccine design; rotavirus; sequence descriptors; web based approaches,"The growing incidences of new viral diseases and increasingly frequent viral epidemics have strained therapeutic and preventive measures; the high mutability of viral genes puts additional strains on developmental efforts. Given the high cost and time requirements for new drugs development, vaccines remain as a viable alternative, but there too traditional techniques of live-attenuated or inactivated vaccines have the danger of allergenic reactions and others. Peptide vaccines have, over the last several years, begun to be looked on as more appropriate alternatives, which are economically affordable, require less time for development and hold the promise of multi-valent dosages. The developments in bioinformatics, proteomics, immunogenomics, structural biology and other sciences have spurred the growth of vaccinomics where computer assisted approaches serve to identify suitable peptide targets for eventual development of vaccines. In this mini-review we give a brief overview of some of the recent trends in computer assisted vaccine development with emphasis on the primary selection procedures of probable peptide candidates for vaccine development.",Pubmed,May 30, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Review,No,Yes,918,Clinical/epidemiological research,Epidemiological/clinical review
919,"Sheffield, BJOG, 2016",Sheffield,"Sheffield, J. S.",Asymptomatic pregnant women returning to the United States from countries experiencing a Zika virus outbreak should be tested for Zika virus : FOR: Importance of identification in ALL pregnant women,BJOG,123,8,1272,2016,2010-present,May 7, 2016,27150136,10.1111/1471-0528.14069,2470,English,http://www.ncbi.nlm.nih.gov/pubmed/27150136,"Johns Hopkins Medicine, Baltimore, MD, USA.",,,,,,,Pubmed,May 30, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,919,,
920,"Saade, BJOG, 2016",Saade,"Saade, G. R.",Asymptomatic pregnant women returning to the United States from countries experiencing a Zika virus outbreak should be tested for Zika virus: AGAINST: Not so fast,BJOG,123,8,1272,2016,2010-present,May 7, 2016,27149896,10.1111/1471-0528.14068,2499,English,http://www.ncbi.nlm.nih.gov/pubmed/27149896,Usa.,,,,,,,Pubmed,May 30, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,920,,
921,"Papageorghiou, BJOG, 2016",Papageorghiou,"Papageorghiou, A. T.",Fetal assessment after Zika exposure,BJOG,123,8,1271,2016,2010-present,May 7, 2016,27150951,10.1111/1471-0528.14074,2540,English,http://www.ncbi.nlm.nih.gov/pubmed/27150951,"Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, UK.; St George's Healthcare NHS Foundation Trust, London, UK.",,,,,,,Pubmed,May 30, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,921,,
922,"Moron, BJOG, 2016",Moron,"Moron, A. F.; Cavalheiro, S.; Milani, H.; Sarmento, S.; Tanuri, C.; de Souza, F. F.; Richtmann, R.; Witkin, S. S.",Microcephaly associated with maternal Zika virus infection,BJOG,123,8,1265-1269,2016,2010-present,May 7, 2016,27150580,10.1111/1471-0528.14072,2555,English,http://www.ncbi.nlm.nih.gov/pubmed/27150580,"Department of Fetal Medicine, Hospital e Maternidade Santa Joana, Sao Paulo, Brazil.; Department of Paediatric Neurosurgery, Hospital e Maternidade Santa Joana, Sao Paulo, Brazil.; Neonatal Intensive Care Unit, Hospital e Maternidade Santa Joana, Sao Paulo, Brazil.; Department of Diagnostic Imaging, Hospital e Maternidade Santa Joana, Sao Paulo, Brazil.; Department of Infectious Diseases, Hospital e Maternidade Santa Joana, Sao Paulo, Brazil.; Department of Obstetrics and Gynecology, Weill Cornell Medicine, New York, NY, USA.",Brazil,Americas,United States,No funding received,,,Pubmed,May 30, 2016,Yes,,Yes,,Scientific (journal) article,Yes,Original research,No,Yes,922,Clinical/epidemiological research,Case report
923,"Molnar, Nat Rev Neurol, 2016",Molnar,"Molnar, Z.; Kennedy, S.",Neurodevelopmental disorders: Risks of Zika virus during the first trimester of pregnancy,Nat Rev Neurol,12,6,315-6,2016,2010-present,May 7, 2016,27150532,10.1038/nrneurol.2016.71,2552,English,http://www.ncbi.nlm.nih.gov/pubmed/27150532,"Department of Physiology, Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, UK.; Nuffield Department of Obstetrics &Gynaecology, University of Oxford, Headington, Oxford OX3 9DU, UK.",,,,,,,Pubmed,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,923,,
924,"Yamada, Nature, 2016",Yamada,"Yamada, T.; Ogawa, V. A.; Freire, M.",Policy: Security spending must cover disease outbreaks,Nature,533,7601,29-31,2016,2010-present,May 7, 2016,27147017,10.1038/533029a,2570,English,http://www.ncbi.nlm.nih.gov/pubmed/27147017,"Global Health Risk Framework Commission, and venture partner at Frazier Healthcare Partners, Seattle, Washington, USA.; Global Health Risk Framework Commission at the US National Academy of Medicine, Washington DC, USA.; Global Health Risk Framework Commission, and president and executive director of the Foundation for the National Institutes of Health, Bethesda, Maryland, USA.",,,,,"Communicable Diseases, Emerging/economics/epidemiology/mortality/prevention &; control; Disaster Planning/*economics/trends; Disease Outbreaks/*economics/prevention & control; Global Health/economics/trends; *Health Expenditures; Humans; Infection/*economics/*epidemiology/mortality; International Cooperation; Pandemics/economics/prevention & control; Public Policy; Public-Private Sector Partnerships/economics; Security Measures/*economics/trends; Zika Virus",,Pubmed,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,924,,
925,"Witkin, BJOG, 2016",Witkin,"Witkin, S. S.",The Zika virus epidemic: professionals and the public search for answers,BJOG,123,8,1255,2016,2010-present,May 7, 2016,27151254,10.1111/1471-0528.14076,2589,English,http://www.ncbi.nlm.nih.gov/pubmed/27151254,"William J. Ledger Distinguished Professor of Infection and Immunology in Ob/Gyn, Weill Cornell Medicine Obstetrics & Gynecology, New York, NY, USA. switkin@med.cornell.edu.",,,,,,,Pubmed,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,925,,
926,"Marrs, BJOG, 2016",Marrs,"Marrs, C. C.",The ultrasound standards for head measurements are appropriate for use in the Zika epidemic : FOR: Standards are the best tools that are currently available,BJOG,123,8,1270,2016,2010-present,May 7, 2016,27151137,10.1111/1471-0528.14075,2441,English,http://www.ncbi.nlm.nih.gov/pubmed/27151137,Usa.,,,,,,,Pubmed,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,926,,
927,"Saade, BJOG, 2016",Saade,"Saade, G. R.",The ultrasound standards for head measurements are appropriate for use in the Zika epidemic: AGAINST: Current standards are inadequate,BJOG,123,8,1270,2016,2010-present,May 7, 2016,27150274,10.1111/1471-0528.14070,2519,English,http://www.ncbi.nlm.nih.gov/pubmed/27150274,Usa.,,,,,,,Pubmed,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,927,,
928,"Dirlikov, MMWR Morb Mortal Wkly Rep, 2016",Dirlikov,"Dirlikov, E.; Ryff, K. R.; Torres-Aponte, J.; Thomas, D. L.; Perez-Padilla, J.; Munoz-Jordan, J.; Caraballo, E. V.; Garcia, M.; Segarra, M. O.; Malave, G.; Simeone, R. M.; Shapiro-Mendoza, C. K.; Reyes, L. R.; Alvarado-Ramy, F.; Harris, A. F.; Rivera, A.; Major, C. G.; Mayshack, M.; Alvarado, L. I.; Lenhart, A.; Valencia-Prado, M.; Waterman, S.; Sharp, T. M.; Rivera-Garcia, B.","Update: Ongoing Zika Virus Transmission - Puerto Rico, November 1, 2015-April 14, 2016",MMWR Morb Mortal Wkly Rep,65,17,451-5,2016,2010-present,May 7, 2016,27149205,10.15585/mmwr.mm6517e2,2289,English,http://www.ncbi.nlm.nih.gov/pubmed/27149205,,,,,,,"Zika virus is a flavivirus transmitted primarily by Aedes species mosquitoes, and symptoms of infection can include rash, fever, arthralgia, and conjunctivitis (1).* Zika virus infection during pregnancy is a cause of microcephaly and other severe brain defects (2). Infection has also been associated with Guillain-Barre syndrome (3). In December 2015, Puerto Rico became the first U.S. jurisdiction to report local transmission of Zika virus, with the index patient reporting symptom onset on November 23, 2015 (4). This report provides an update to the epidemiology of and public health response to ongoing Zika virus transmission in Puerto Rico. During November 1, 2015-April 14, 2016, a total of 6,157 specimens from suspected Zika virus-infected patients were evaluated by the Puerto Rico Department of Health (PRDH) and CDC Dengue Branch (which is located in San Juan, Puerto Rico), and 683 (11%) had laboratory evidence of current or recent Zika virus infection by one or more tests: reverse transcription-polymerase chain reaction (RT-PCR) or immunoglobulin M (IgM) enzyme-linked immunosorbent assay (ELISA). Zika virus-infected patients resided in 50 (64%) of 78 municipalities in Puerto Rico. Median age was 34 years (range = 35 days-89 years). The most frequently reported signs and symptoms were rash (74%), myalgia (68%), headache (63%), fever (63%), and arthralgia (63%). There were 65 (10%) symptomatic pregnant women who tested positive by RT-PCR or IgM ELISA. A total of 17 (2%) patients required hospitalization, including 5 (1%) patients with suspected Guillain-Barre syndrome. One (<1%) patient died after developing severe thrombocytopenia. The public health response to the outbreak has included increased laboratory capacity to test for Zika virus infection (including blood donor screening), implementation of enhanced surveillance systems, and prevention activities focused on pregnant women. Vector control activities include indoor and outdoor residual spraying and reduction of mosquito breeding environments focused around pregnant women's homes. Residents of and travelers to Puerto Rico should continue to employ mosquito bite avoidance behaviors, take precautions to reduce the risk for sexual transmission (5), and seek medical care for any acute illness with rash or fever.",Pubmed,May 30, 2016,Yes,,No,"Zika, not relevant to causality framework",Scientific (journal) article,No,Original research,No,Yes,928,Clinical/epidemiological research,Ecological study/outbreak report
929,"Aman, PLoS Negl Trop Dis, 2016",Aman,"Aman, M. J.; Kashanchi, F.",Zika Virus: A New Animal Model for an Arbovirus,PLoS Negl Trop Dis,10,5,e0004702,2016,2010-present,May 7, 2016,27149628,10.1371/journal.pntd.0004702,2310,English,http://www.ncbi.nlm.nih.gov/pubmed/27149628,"Integrated BioTherapeutics, Inc., Gaithersburg, Maryland, United States of America.; Laboratory of Molecular Virology, George Mason University, Manassas, Virginia, United States of America.",,,,,,,Pubmed,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,929,,
930,"Burke, BJOG, 2016",Burke,"Burke, R. M.; Candfield, S.; Gothard, P.",Zika virus and microcephaly - more questions than answers?,BJOG,123,8,1264,2016,2010-present,May 7, 2016,27150736,10.1111/1471-0528.14073,2272,English,http://www.ncbi.nlm.nih.gov/pubmed/27150736,"Hospital for Tropical Diseases, Infection Division, University College London Hospitals FT, London, UK.",,,,,,,Pubmed,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,930,,
931,"Lissauer, BJOG, 2016",Lissauer,"Lissauer, D.; Smit, E.; Kilby, M. D.",Zika virus and pregnancy,BJOG,123,8,1258-63,2016,2010-present,May 7, 2016,27150456,10.1111/1471-0528.14071,2432,English,http://www.ncbi.nlm.nih.gov/pubmed/27150456,"Centre for Women's & Newborn Health, Institute of Metabolism and Systems Research, College of Medical & Dental Science, University of Birmingham, Birmingham, UK.; Fetal Medicine Centre, Birmingham Women's Foundation Trust (Birmingham Health Partners), Edgbaston, Birmingham, UK.; Public Health England, West Midlands Public Health Laboratory, Heart of England NHS Foundation Trust, Birmingham, UK.",,,,,,,Pubmed,May 30, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,931,,
932,"Kirtley, BJOG, 2016",Kirtley,"Kirtley, S.",Zika virus in pregnancy: where to find useful guidance,BJOG,123,8,1256-7,2016,2010-present,May 7, 2016,27151369,10.1111/1471-0528.14077,2383,English,http://www.ncbi.nlm.nih.gov/pubmed/27151369,shona.kirtley@csm.ox.ac.uk.,,,,,,,Pubmed,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,932,,
933,"Miner, Cell Stem Cell, 2016",Miner,"Miner, J. J.; Diamond, M. S.",Understanding How Zika Virus Enters and Infects Neural Target Cells,Cell Stem Cell,18,5,559-60,2016,2010-present,May 8, 2016,27152436,10.1016/j.stem.2016.04.009,2512,English,http://www.ncbi.nlm.nih.gov/pubmed/27152436,"Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.; Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA; Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address: diamond@borcim.wustl.edu.",,,,,,"Zika virus is a mosquito-transmitted flavivirus that has become a public health concern because of its ability to cause microcephaly. In this issue of Cell Stem Cell, Tang et al. (2016) and Nowakowski et al. (2016) use human neural stem cell models and single-cell RNA sequencing to investigate Zika virus tropism and potential entry receptors.",Pubmed,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,933,,
934,"Jimenez Corona, PLoS Curr, 2016",Jimenez Corona,"Jimenez Corona, M. E.; De la Garza Barroso, A. L.; Rodriguez Martinez, J. C.; Luna Guzman, N. I.; Ruiz Matus, C.; Diaz Quinonez, J. A.; Lopez Martinez, I.; Kuri Morales, P. A.",Clinical and Epidemiological Characterization of Laboratory-Confirmed Autochthonous Cases of Zika Virus Disease in Mexico,PLoS Curr,8,,,2016,2010-present,May 10, 2016,27158557,10.1371/currents.outbreaks.a2fe1b3d6d71e24ad2b5afe982824053,2389,English,http://www.ncbi.nlm.nih.gov/pubmed/27158557,"General Directorate of Epidemiology, Ministry of Health, Mexico City, Mexico.; Direccion General Adjunta de Epidemiologia, Direccion General de Epidemiologia, Secretaria de Salud, Mexico City, Mexico.; Direccion de Vigilancia de Enfermedades Transmisibles, Direccion General de Epidemiologia, Secretaria de Salud, Mexico City, Mexico.; Direccion General de Epidemiologia, Secretaria de Salud, Mexico City, Mexico.; Facultad de Medicina, Universidad Nacional Autonoma de Mexico, Mexico City, Mexico; Instituto de Diagnostico y Referencia Epidemiologicos (InDRE) 'Dr. Manuel Martinez Baez', Mexico City, Mexico.; Instituto de Diagnostico y Referencia Epidemiologicos (InDRE) 'Dr. Manuel Martinez Baez', Mexico City, Mexico.; Subsecretaria de Prevencion y Promocion de la Salud, Secretaria de Salud, Mexico City, Mexico.",,,,,Epidemiology; Surveillance; Zika; arbovirus,"INTRODUCTION: Since 2014, autochthonous circulation of Zika virus (ZIKV) in the Americas was detected (Easter Island, Chile). In May 2015, Brazil confirmed autochthonous --transmission and in October of that year Colombia reported their first cases. Now more than 52 countries have reported cases, including Mexico. To deal with this contingency in Mexico, several surveillance systems, in addition to systems for vector-borne diseases were strengthened with the participation of all health institutions. Also, the Ministry of Health defined an Action Plan against ZIKV for the whole country. METHODS: We analyzed 93 autochthonous cases of ZIKV disease identified by Epidemiological Surveillance System for Zika Virus in Mexico. All autochthonous cases confirmed by laboratory since November 25, 2015 to February 19, 2016 were included. A description of clinical and epidemiological characteristics of 93 cases of ZIKV disease are presenting and, we describe the Action Plan against this public health emergency. RESULTS: The distribution of cases by sex was 61 men and 32 women; mean age was 35 years old (S.D. 15, range 6-90). The main clinical features in the 93 cases were fever (96.6%), rash (93.3%), non-purulent conjunctivitis (88.8%), headache (85.4%), and myalgia (84.3%). No deaths were reported. CONCLUSION: The ZIKV epidemic poses new challenges to public health systems. The information provided for basic, clinical, and epidemiological research, in addition to the data derived from epidemiological surveillance is essential. However, there are still many unanswered questions regarding mechanisms of transmission, complications, and impact of this virus.",Pubmed,May 30, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Original research,No,Yes,934,Clinical/epidemiological research,Case series
935,"Ye, Infect Genet Evol, 2016",Ye,"Ye, Q.; Liu, Z. Y.; Han, J. F.; Jiang, T.; Li, X. F.; Qin, C. F.",Genomic characterization and phylogenetic analysis of Zika virus circulating in the Americas,Infect Genet Evol,43,,43-49,2016,2010-present,May 10, 2016,27156653,10.1016/j.meegid.2016.05.004,2635,English,http://www.ncbi.nlm.nih.gov/pubmed/27156653,"Department of Virology, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China.; Department of Virology, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China; State Key Laboratory of Pathogen and Biosecurity, Beijing 100071, China.; Department of Virology, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China; State Key Laboratory of Pathogen and Biosecurity, Beijing 100071, China. Electronic address: qincf@bmi.ac.cn.",,,,,Flavivirus; Genomic characterization; Phylogenetics; Zika virus,"The rapid spread and potential link with birth defects have made Zika virus (ZIKV) a global public health problem. The virus was discovered 70years ago, yet the knowledge about its genomic structure and the genetic variations associated with current ZIKV explosive epidemics remains not fully understood. In this review, the genome organization, especially conserved terminal structures of ZIKV genome were characterized and compared with other mosquito-borne flaviviruses. It is suggested that major viral proteins of ZIKV share high structural and functional similarity with other known flaviviruses as shown by sequence comparison and prediction of functional motifs in viral proteins. Phylogenetic analysis demonstrated that all ZIKV strains circulating in the America form a unique clade within the Asian lineage. Furthermore, we identified a series of conserved amino acid residues that differentiate the Asian strains including the current circulating American strains from the ancient African strains. Overall, our findings provide an overview of ZIKV genome characterization and evolutionary dynamics in the Americas and point out critical clues for future virological and epidemiological studies.",Pubmed,May 30, 2016,Yes,,No,"Zika, not relevant to causality framework",Scientific (journal) article,Yes,Original research,No,Yes,935,Basic and applied biomedical research,Sequence analysis and phylogenetics
936,"Machado-Alba, Lancet, 2016",Machado-Alba,"Machado-Alba, J. E.; Machado-Duque, M. E.; Gaviria-Mendoza, A.; Orozco-Giraldo, V. A.",Hormonal contraceptive prescriptions in Colombia and Zika virus,Lancet,387,10032,1993,2016,2010-present,May 10, 2016,27156436,10.1016/S0140-6736(16)30429-9,2399,English,http://www.ncbi.nlm.nih.gov/pubmed/27156436,"Grupo de Investigacion en Farmacoepidemiologia y Farmacovigilancia, Universidad Tecnologica de Pereira, Pereira, Colombia; Audifarma SA, Pereira, Colombia. Electronic address: machado@utp.edu.co.; Grupo de Investigacion en Farmacoepidemiologia y Farmacovigilancia, Universidad Tecnologica de Pereira, Pereira, Colombia; Audifarma SA, Pereira, Colombia.",,,,,"Adult; Colombia/epidemiology; *Contraceptives, Oral, Hormonal; Disease Outbreaks; Drug Prescriptions/*statistics & numerical data; Female; Humans; Microcephaly/epidemiology/virology; Zika Virus Infection/*epidemiology",,Pubmed,May 30, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,936,,
937,"Dai, Cell Host Microbe, 2016",Dai,"Dai, L.; Song, J.; Lu, X.; Deng, Y. Q.; Musyoki, A. M.; Cheng, H.; Zhang, Y.; Yuan, Y.; Song, H.; Haywood, J.; Xiao, H.; Yan, J.; Shi, Y.; Qin, C. F.; Qi, J.; Gao, G. F.",Structures of the Zika Virus Envelope Protein and Its Complex with a Flavivirus Broadly Protective Antibody,Cell Host Microbe,19,5,696-704,2016,2010-present,May 10, 2016,27158114,10.1016/j.chom.2016.04.013,2320,English,http://www.ncbi.nlm.nih.gov/pubmed/27158114,"Research Network of Immunity and Health (RNIH), Beijing Institutes of Life Science, Chinese Academy of Sciences, Beijing 100101, China.; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100071, China; Savaid Medical School, University of Chinese Academy of Sciences, Beijing 100049, China.; Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, China.; State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100101, China.; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100071, China; Savaid Medical School, University of Chinese Academy of Sciences, Beijing 100049, China; Shenzhen Key Laboratory of Pathogen and Immunity, Shenzhen Third People's Hospital, Shenzhen 518112, China; Center for Influenza Research and Early-warning (CASCIRE), Chinese Academy of Sciences, Beijing 100101, China; CAS Key Laboratory of Microbial Physiology and Engineering, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.; Research Network of Immunity and Health (RNIH), Beijing Institutes of Life Science, Chinese Academy of Sciences, Beijing 100101, China; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100071, China; Savaid Medical School, University of Chinese Academy of Sciences, Beijing 100049, China; Shenzhen Key Laboratory of Pathogen and Immunity, Shenzhen Third People's Hospital, Shenzhen 518112, China; Center for Influenza Research and Early-warning (CASCIRE), Chinese Academy of Sciences, Beijing 100101, China.; State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100101, China. Electronic address: qincf@bmi.ac.cn.; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100071, China. Electronic address: jxqi@im.ac.cn.; Research Network of Immunity and Health (RNIH), Beijing Institutes of Life Science, Chinese Academy of Sciences, Beijing 100101, China; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100071, China; Savaid Medical School, University of Chinese Academy of Sciences, Beijing 100049, China; Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, China; Shenzhen Key Laboratory of Pathogen and Immunity, Shenzhen Third People's Hospital, Shenzhen 518112, China; Center for Influenza Research and Early-warning (CASCIRE), Chinese Academy of Sciences, Beijing 100101, China; Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou 310003, China; National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention (China CDC), Beijing 102206, China. Electronic address: gaof@im.ac.cn.",,,,,,"Zika virus (ZIKV), a mosquito-borne flavivirus, is a current global public health concern. The flavivirus envelope (E) glycoprotein is responsible for virus entry and represents a major target of neutralizing antibodies for other flaviviruses. Here, we report the structures of ZIKV E protein at 2.0 A and in complex with a flavivirus broadly neutralizing murine antibody 2A10G6 at 3.0 A. ZIKV-E resembles all the known flavivirus E structures but contains a unique, positively charged patch adjacent to the fusion loop region of the juxtaposed monomer, which may influence host attachment. The ZIKV-E-2A10G6 complex structure reveals antibody recognition of a highly conserved fusion loop. 2A10G6 binds to ZIKV-E with high affinity in vitro and neutralizes currently circulating ZIKV strains in vitro and in mice. The E protein fusion loop epitope represents a potential candidate for therapeutic antibodies against ZIKV.",Pubmed,May 30, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Original research,No,Yes,937,Basic and applied biomedical research,Animal experiment
938,", Nurs Child Young People, 2016",,,Travellers warned about Zika virus,Nurs Child Young People,28,4,9,2016,2010-present,May 10, 2016,27156408,10.7748/ncyp.28.4.9.s10,2331,English,http://www.ncbi.nlm.nih.gov/pubmed/27156408,,,,,,,"NHS STAFF working in primary care have been advised to take a more precautionary approach to the Zika virus, particularly with pregnant women.",Pubmed,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,938,,
939,"Long, J Emerg Med, 2016",Long,"Long, D.; Long, B.; Koyfman, A.",Zika Virus: What Do Emergency Physicians Need to Know?,J Emerg Med,50,6,832-8,2016,2010-present,May 10, 2016,27157106,10.1016/j.jemermed.2016.03.033,2463,English,http://www.ncbi.nlm.nih.gov/pubmed/27157106,"Vanderbilt University School of Medicine, Nashville, Tennessee.; Department of Emergency Medicine, San Antonio Military Medical Center, Fort Sam Houston, Texas.; Department of Emergency Medicine, The University of Texas Southwestern Medical Center, Dallas, Texas.",,,,,Aedes; Zika virus; blood; flavivirus; microcephaly; mosquito,"BACKGROUND: Zika virus currently dominates headlines, creating public fear due to its complications. With the ease of worldwide travel, this disease has spread rapidly to the U.S. OBJECTIVES: To provide physicians with an updated clinical review of the epidemiology, pathogenesis, diagnosis, management, and mimics of zika virus. DISCUSSION: This flavivirus is spread by the bite of the Aedes mosquito during daylight. The ease of worldwide travel has allowed the virus to spread to Mexico and the U.S. Main transmission route is via blood contact or sexual activity involving mucous membranes. Incubation ranges from 2 to 12 days, but only 20% of patients experience symptoms. Fever is low grade with conjunctivitis, arthralgias, myalgias, and a maculopapular rash. Chikungunya and Dengue Fever differ in that patients experience higher fever and no conjunctivitits. The dreaded complication of Zika virus is microcephaly in infants born to infected mothers. Guillain-Barre Syndrome is also linked to the virus. Historical factors including travel history are paramount, and diagnosis includes PCR or serology. No current treatment regimen exists beyond symptom control. The emergency physician must seek to rule out other similar diseases such as malaria, chikungunya, and dengue fever. CONCLUSION: Zika virus has created public fear due to complications, and this flavivirus spread by the Aedes mosquito presents similarly to Chikungunya and Dengue Fever. The dreaded complication of Zika virus is microcephaly in infants born to infected mothers. This review provides key information concerning the disease and management.",Pubmed,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,939,,
940,"Singh, Vet Q, 2016",Singh,"Singh, R. K.; Dhama, K.; Malik, Y. S.; Ramakrishnan, M. A.; Karthik, K.; Tiwari, R.; Saurabh, S.; Sachan, S.; Joshi, S. K.","Zika virus - emergence, evolution, pathology, diagnosis, and control: current global scenario and future perspectives - a comprehensive review",Vet Q,,,Jan 26,2016,2010-present,May 10, 2016,27158761,10.1080/01652176.2016.1188333,2532,English,http://www.ncbi.nlm.nih.gov/pubmed/27158761,"a ICAR-Indian Veterinary Research Institute , Bareilly , India.; b Division of Pathology , ICAR-Indian Veterinary Research Institute , Bareilly , India.; c Division of Biological Standardization , ICAR-Indian Veterinary Research Institute , Bareilly , India.; d Division of Virology , ICAR-Indian Veterinary Research Institute, Mukteswar Campus , Uttarakhand , India.; e Division of Bacteriology and Mycology , ICAR-Indian Veterinary Research Institute , Bareilly , India.; f Department of Veterinary Microbiology and Immunology , College of Veterinary Sciences, Deen Dayal Upadhayay Pashu Chikitsa Vigyan Vishwavidyalay Evum Go-Anusandhan Sansthan , Mathura , India.; g Immunology Section , ICAR-Indian Veterinary Research Institute , Bareilly , India.; h Cellular Immunology Lab, Frank Reidy Research Center for Bioelectrics , School of Medical Diagnostics & Translational Sciences, Old Dominion University , Norfolk , VA , USA.",,,,,Zika virus; flavivirus; global warming; review; zoonosis,"This review converses the Zika virus which has attained global concern due to its rapid pandemic potential and impact on humans. Though Zika virus was first isolated in 1947, till the recent large-scale outbreak which occurred in Micronesia, in 2007, the virus was placed into the innocuous pathogen category. The World Health Organization on 1 February 2016 declared it as a 'Public Health Emergency of International Concern.' Of the note, American as well as Pacific Island strains/isolates is relatively closer to Asian lineage strains. The African and American strains share more than 87.5% and 95% homologies with Asian strains/isolates, respectively. Asian strains form independent clusters, except those isolated from China, suggesting relatively more diversity than African strains. Prevention and control are mainly aimed at the vector population (mosquitoes) with Aedes aegypti being the main species. Surveys in Africa and Asia indicated seropositivity in various animal species. However, so far its natural reservoir is unknown. There is an urgent need to understand why Zika virus has shifted from being a virus that caused mild illness to unforeseen birth defects as well as autoimmune-neurological problems. Unfortunately, an effective vaccine is not available yet. Availability of cryo-electron microscopy based on 3.8 A resolution revealing mature Zika virus structure and the probable virus attachment site to host cell would provide critical insights into the development of antiviral treatments and vaccines.",Pubmed,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Yes,Review,No,Yes,940,Clinical/epidemiological research,Epidemiological/clinical review
941,"Musso, Lancet, 2016",Musso,"Musso, D.; Stramer, S. L.; Aabb Transfusion-Transmitted Diseases Committee; Busch, M. P.; International Society of Blood Transfusion Working Party on Transfusion-Transmitted Infectious, Diseases",Zika virus: a new challenge for blood transfusion,Lancet,387,10032,1993-4,2016,2010-present,May 10, 2016,27156435,10.1016/S0140-6736(16)30428-7,2541,English,http://www.ncbi.nlm.nih.gov/pubmed/27156435,"Unit of Emerging Infectious Diseases, Institut Louis Malarde, Tahiti, French Polynesia. Electronic address: dmusso@ilm.pf.; American Red Cross, Gaithersburg, MD, USA.; International Society of Blood Transfusions, Blood Systems Research Institute, San Francisco, CA, USA.",,,,,Blood Transfusion/*adverse effects; Donor Selection; Humans; Zika Virus Infection/prevention & control/*transmission,,Pubmed,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,941,,
942,"Valerio Sallent, Med Clin (Barc), 2016",Valerio Sallent,"Valerio Sallent, L.; Roure Diez, S.; Fernandez Rivas, G.",[Zika virus infection or the future of infectious diseases],Med Clin (Barc),,,,2016,2010-present,May 10, 2016,27156484,10.1016/j.medcli.2016.03.012,2472,Spanish,http://www.ncbi.nlm.nih.gov/pubmed/27156484,"PROSICS Metropolitana Nord, Institut Catala de la Salut, Universitat Autonoma de Barcelona, Santa Coloma de Gramenet, Espana. Electronic address: lvalerio.bnm.ics@gencat.cat.; PROSICS Metropolitana Nord, Unidad de Enfermedades Infecciosas, Servicio de Medicina Interna, Hospital Universitari Germans Trias i Pujol, Universitat Autonoma de Barcelona, Institut Catala de la Salut, Badalona, Barcelona, Espana.; Servicio de Microbiologia, Hospital Universitari Germans Trias i Pujol Universitat Autonoma de Barcelona, Institut Catala de la Salut, Badalona, Barcelona, Espana.",,,,,Aedes albopictus; Europa; Europe; Zika,"Zika virus belongs to the Flaviridae, an extended phylogenetic family containing dengue or yellow fever, viruses whose shared main vector are Aedes aegypti mosquitoes. The virus originally came from Central African simian reservoirs and, from there, expanded rapidly across the Pacific to South America. The disease is an example of exantematic fever usually mild. Mortality is very low and mainly limited to secondary Guillain-Barre or fetal microcephaly cases. Diagnostic confirmation requires a RT-PCR in blood up to the 5th day from the onset or in urine up to the 10-14th day. Specific IgM are identifiable from the 5th symptomatic day. Clinically, a suspected case should comply with: a) a journey to epidemic areas; b) a clinically compatible appearance with fever and skin rash, and c) a generally normal blood count/basic biochemistry. There is some evidence that causally relates Zika virus infection with fetal microcephaly. While waiting for definitive data, all pregnant women coming from Central or South America should be tested for Zika virus.",Pubmed,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,942,,
943,"Gioula, Eur J Paediatr Neurol, 2016",Gioula,"Gioula, G.; Nunes, M. L.; Zafeiriou, D. I.","An emerging cause of concern in Europe: Zika virus, the developing CNS and the pediatric neurologist",Eur J Paediatr Neurol,20,4,497-9,2016,2010-present,May 11, 2016,27160366,10.1016/j.ejpn.2016.04.017,2394,English,http://www.ncbi.nlm.nih.gov/pubmed/27160366,"2nd Department of Microbiology, Aristotle University, Thessaloniki, Greece.; Divison of Neurology, Pontificia Universidade Catolica do Rio Grande do Sul and Brain Institute of Rio Grande do Sul, Porto Alegre, Brazil.; 1st Department of Pediatrics, Aristotle University, Thessaloniki, Greece. Electronic address: jeff@med.auth.gr.",,,,,,,Pubmed,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,943,,
944,"Behura, BMC Genomics, 2016",Behura,"Behura, S. K.; Sarro, J.; Li, P.; Mysore, K.; Severson, D. W.; Emrich, S. J.; Duman-Scheel, M.",High-throughput cis-regulatory element discovery in the vector mosquito Aedes aegypti,BMC Genomics,17,1,341,2016,2010-present,May 11, 2016,27161480,10.1186/s12864-016-2468-x,2279,English,http://www.ncbi.nlm.nih.gov/pubmed/27161480,"Eck Institute for Global Health, University of Notre Dame, Notre Dame, IN, 46556, USA.; Department of Biological Sciences, University of Notre Dame, Notre Dame, IN, 46556, USA.; Department of Medical and Molecular Genetics, Indiana University School of Medicine, 1234 Notre Dame Ave., South Bend, IN, 46617, USA.; Eck Institute for Global Health, University of Notre Dame, Notre Dame, IN, 46556, USA. semrich@nd.edu.; Department of Biological Sciences, University of Notre Dame, Notre Dame, IN, 46556, USA. semrich@nd.edu.; Department of Computer Science and Engineering, University of Notre Dame, Notre Dame, IN, 46556, USA. semrich@nd.edu.; Eck Institute for Global Health, University of Notre Dame, Notre Dame, IN, 46556, USA. mscheel@nd.edu.; Department of Biological Sciences, University of Notre Dame, Notre Dame, IN, 46556, USA. mscheel@nd.edu.; Department of Medical and Molecular Genetics, Indiana University School of Medicine, 1234 Notre Dame Ave., South Bend, IN, 46617, USA. mscheel@nd.edu.",,,,,Dengue virus; Drosophila; FAIRE-seq; Genome; Next generation sequencing; Zika,"BACKGROUND: Despite substantial progress in mosquito genomic and genetic research, few cis-regulatory elements (CREs), DNA sequences that control gene expression, have been identified in mosquitoes or other non-model insects. Formaldehyde-assisted isolation of regulatory elements paired with DNA sequencing, FAIRE-seq, is emerging as a powerful new high-throughput tool for global CRE discovery. FAIRE results in the preferential recovery of open chromatin DNA fragments that are not bound by nucleosomes, an evolutionarily conserved indicator of regulatory activity, which are then sequenced. Despite the power of the approach, FAIRE-seq has not yet been applied to the study of non-model insects. In this investigation, we utilized FAIRE-seq to profile open chromatin and identify likely regulatory elements throughout the genome of the human disease vector mosquito Aedes aegypti. We then assessed genetic variation in the regulatory elements of dengue virus susceptible (Moyo-S) and refractory (Moyo-R) mosquito strains. RESULTS: Analysis of sequence data obtained through next generation sequencing of FAIRE DNA isolated from A. aegypti embryos revealed >121,000 FAIRE peaks (FPs), many of which clustered in the 1 kb 5' upstream flanking regions of genes known to be expressed at this stage. As expected, known transcription factor consensus binding sites were enriched in the FPs, and of these FoxA1, Hunchback, Gfi, Klf4, MYB/ph3 and Sox9 are most predominant. All of the elements tested in vivo were confirmed to drive gene expression in transgenic Drosophila reporter assays. Of the >13,000 single nucleotide polymorphisms (SNPs) recently identified in dengue virus-susceptible and refractory mosquito strains, 3365 were found to map to FPs. CONCLUSION: FAIRE-seq analysis of open chromatin in A. aegypti permitted genome-wide discovery of CREs. The results of this investigation indicate that FAIRE-seq is a powerful tool for identification of regulatory DNA in the genomes of non-model organisms, including human disease vector mosquitoes.",Pubmed,May 30, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Original research,No,Yes,944,Environmental and vector research,Vector control studies
945,"Brooks, BMJ, 2016",Brooks,"Brooks, M.",Mosquitoes and Zika: time to harness genetic modification?,BMJ,353,,i2548,2016,2010-present,May 11, 2016,27160110,10.1136/bmj.i2548,2276,English,http://www.ncbi.nlm.nih.gov/pubmed/27160110,,,,,,,,Pubmed,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,945,,
946,"Pardee, Cell, 2016",Pardee,"Pardee, K.; Green, A. A.; Takahashi, M. K.; Braff, D.; Lambert, G.; Lee, J. W.; Ferrante, T.; Ma, D.; Donghia, N.; Fan, M.; Daringer, N. M.; Bosch, I.; Dudley, D. M.; O'Connor, D. H.; Gehrke, L.; Collins, J. J.","Rapid, Low-Cost Detection of Zika Virus Using Programmable Biomolecular Components",Cell,165,5,1255-66,2016,2010-present,May 11, 2016,27160350,10.1016/j.cell.2016.04.059,2505,English,http://www.ncbi.nlm.nih.gov/pubmed/27160350,"Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON M5S 3M2, Canada.; Biodesign Center for Molecular Design and Biomimetics, The Biodesign Institute and the School of Molecular Sciences, Arizona State University, AZ 85287, USA.; Institute for Medical Engineering & Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Institute for Medical Engineering & Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA.; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA; School of Applied and Engineering Physics, Cornell University, Ithaca, NY 14853, USA.; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA.; Addgene, Cambridge, MA 02139, USA.; Wisconsin National Primate Research Center and Department of Pathology and Laboratory Medicine, UW-Madison, Madison, WI 53706, USA.; Institute for Medical Engineering & Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA; Harvard-MIT Program in Health Sciences and Technology, Cambridge, MA 02139, USA.; Institute for Medical Engineering & Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA; Harvard-MIT Program in Health Sciences and Technology, Cambridge, MA 02139, USA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Synthetic Biology Center, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address: jimjc@mit.edu.",,,,,,"The recent Zika virus outbreak highlights the need for low-cost diagnostics that can be rapidly developed for distribution and use in pandemic regions. Here, we report a pipeline for the rapid design, assembly, and validation of cell-free, paper-based sensors for the detection of the Zika virus RNA genome. By linking isothermal RNA amplification to toehold switch RNA sensors, we detect clinically relevant concentrations of Zika virus sequences and demonstrate specificity against closely related Dengue virus sequences. When coupled with a novel CRISPR/Cas9-based module, our sensors can discriminate between viral strains with single-base resolution. We successfully demonstrate a simple, field-ready sample-processing workflow and detect Zika virus from the plasma of a viremic macaque. Our freeze-dried biomolecular platform resolves important practical limitations to the deployment of molecular diagnostics in the field and demonstrates how synthetic biology can be used to develop diagnostic tools for confronting global health crises. PAPERCLIP.",Pubmed,May 30, 2016,Yes,,No,"Zika, not relevant to causality framework",Scientific (journal) article,Yes,Original research,No,Yes,946,Clinical/epidemiological research,Diagnostic study
947,"Dang, Cell Stem Cell, 2016",Dang,"Dang, J.; Tiwari, S. K.; Lichinchi, G.; Qin, Y.; Patil, V. S.; Eroshkin, A. M.; Rana, T. M.",Zika Virus Depletes Neural Progenitors in Human Cerebral Organoids through Activation of the Innate Immune Receptor TLR3,Cell Stem Cell,,,,2016,2010-present,May 11, 2016,27162029,10.1016/j.stem.2016.04.014,2364,English,http://www.ncbi.nlm.nih.gov/pubmed/27162029,"Department of Pediatrics, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA; Department of Bioengineering, University of California San Diego, La Jolla, CA 92093, USA.; Department of Pediatrics, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.; Department of Pediatrics, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA; Graduate School of Biomedical Sciences, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.; Bioinformatics core, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.; Department of Pediatrics, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA; Institute for Genomic Medicine, University of California San Diego, La Jolla, CA 92093, USA. Electronic address: trana@ucsd.edu.",United States,Americas,United States,Public/Government,Toll-like receptors; Zika virus; microcephaly; organoids,"Emerging evidence from the current outbreak of Zika virus (ZIKV) indicates a strong causal link between Zika and microcephaly. To investigate how ZIKV infection leads to microcephaly, we used human embryonic stem cell-derived cerebral organoids to recapitulate early stage, first trimester fetal brain development. Here we show that a prototype strain of ZIKV, MR766, efficiently infects organoids and causes a decrease in overall organoid size that correlates with the kinetics of viral copy number. The innate immune receptor Toll-like-Receptor 3 (TLR3) was upregulated after ZIKV infection of human organoids and mouse neurospheres and TLR3 inhibition reduced the phenotypic effects of ZIKV infection. Pathway analysis of gene expression changes during TLR3 activation highlighted 41 genes also related to neuronal development, suggesting a mechanistic connection to disrupted neurogenesis. Together, therefore, our findings identify a link between ZIKV-mediated TLR3 activation, perturbed cell fate, and a reduction in organoid volume reminiscent of microcephaly.",Pubmed,May 30, 2016,Yes,,Yes,,Scientific (journal) article,Yes,Original research,No,Yes,947,Basic and applied biomedical research,In vitro experiment
948,"Kassavetis, Neurology, 2016",Kassavetis,"Kassavetis, P.; Joseph, J. B.; Francois, R.; Perloff, M. D.; Berkowitz, A. L.",Zika virus-associated Guillain-Barre syndrome variant in Haiti,Neurology,,,,2016,2010-present,May 11, 2016,27164708,10.1212/WNL.0000000000002759,2375,English,http://www.ncbi.nlm.nih.gov/pubmed/27164708,"From the Department of Neurology (P.K., M.D.P.), Boston University Medical Center, Boston, MA; Hopital Universitaire de Mirebalais (J.-M.B.J., R.F., A.L.B.), Mirebalais, Haiti; and Brigham and Women's Hospital (A.L.B.), Boston, MA.; From the Department of Neurology (P.K., M.D.P.), Boston University Medical Center, Boston, MA; Hopital Universitaire de Mirebalais (J.-M.B.J., R.F., A.L.B.), Mirebalais, Haiti; and Brigham and Women's Hospital (A.L.B.), Boston, MA. aberkowitz3@partners.org.",United States,Americas,United States,No funding received,,,Pubmed,May 30, 2016,Yes,,Yes,,Scientific (journal) article,Unknown/unclear,Original research,No,Yes,948,Clinical/epidemiological research,Case report
949,", Emerg Nurse, 2016",,,Effects of Zika virus,Emerg Nurse,24,2,17,2016,2010-present,May 12, 2016,27165390,10.7748/en.24.2.17.s22,2326,English,http://www.ncbi.nlm.nih.gov/pubmed/27165390,,,,,,,A review of computerised tomography (CT) and magnetic resonance imaging (MRI) scans of babies born with microcephaly in Brazil has confirmed a range of brain abnormalities associated with presumed Zika infection during pregnancy.,Pubmed,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,949,,
950,"PAHO, Epidemiological update. Zika virus infection - 28 April 2016, 2016",PAHO,PAHO,Epidemiological update. Zika virus infection - 28 April 2016,,Epidemiological update. Zika virus infection - 28 April 2016,,,2016,2010-present,May 12, 2016,,,2733,,http://www.paho.org/hq/index.php?option=com_docman&task=doc_view&Itemid=270&gid=34553&lang=en,,United States,Americas,,Public/Government,,,PAHO,May 30, 2016,Yes,,Yes,,Surveillance report or data,,,No,Yes,950,Clinical/epidemiological research,Ecological study/outbreak report
951,"Derrington, JAMA Dermatol, 2016",Derrington,"Derrington, S. M.; Cellura, A. P.; McDermott, L. E.; Gubitosi, T.; Sonstegard, A. M.; Chen, S.; Garg, A.",Mucocutaneous Findings and Course in an Adult With Zika Virus Infection,JAMA Dermatol,152,6,691-3,2016,2010-present,May 12, 2016,27168495,10.1001/jamadermatol.2016.1433,2311,English,http://www.ncbi.nlm.nih.gov/pubmed/27168495,"Department of Dermatology, Hofstra Northwell School of Medicine, Hempstead, New York.",,,,,,"IMPORTANCE: The Zika virus epidemic has been declared a public health emergency of international concern by the World Health Organization. We describe the mucocutaneous features and histologic correlation in a patient with the acute Zika virus infection. OBSERVATIONS: We observed the presence of a diffuse papular descending eruption, petechiae on the palate, and hyperemic sclerae in a 44-year-old man returning from Puerto Rico with confirmatory testing for the Zika virus. CONCLUSIONS AND RELEVANCE: A detailed awareness of mucocutaneous findings associated with Zika virus infection will support its early recognition and will facilitate elimination of Zika infection from consideration for concerned patients who present with other, more common erythematous eruptions.",Pubmed,May 30, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Original research,No,Yes,951,Clinical/epidemiological research,Case report
952,"InVS, Point Epidemiologique CIRE Antilles Guyane, 2016",InVS,InVS,Point epidemio: Emergence du virus zika aux Antilles Guyane : Situation epidemiologique - 12 mai 2016,Point Epidemiologique CIRE Antilles Guyane,18,,,2016,2010-present,May 12, 2016,,,2216,French,http://www.invs.sante.fr/fr/Publications-et-outils/Points-epidemiologiques/Tous-les-numeros/Antilles-Guyane/2016/Situation-epidemiologique-du-virus-Zika-aux-Antilles-Guyane.-Point-au-12-mai-2016,,France,Europe,,Public/Government,,,Institute de veille sanitaire,May 30, 2016,Yes,,No,"Zika, indirect evidence or other topic",Surveillance report or data,,,No,Yes,952,Clinical/epidemiological research,Ecological study/outbreak report
953,"Simoes, Rev Assoc Med Bras, 2016",Simoes,"Simoes, R.; Buzzini, R.; Bernardo, W.; Cardoso, F.; Salomao, A.; Cerri, G.",Update on Zika virus infection in pregnancy,Rev Assoc Med Bras,62,2,106-7,2016,2010-present,May 12, 2016,27167537,10.1590/1806-9282.62.02.106,2469,English,http://www.ncbi.nlm.nih.gov/pubmed/27167537,"Federacao Brasileira das Associacoes de Ginecologia e Obstetricia, Brazil.; AMB, Brazil.",,,,,,,Pubmed,May 30, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,953,,
954,"Robinson, JAMA Dermatol, 2016",Robinson,"Robinson, J. K.",Zika Virus,JAMA Dermatol,152,6,693,2016,2010-present,May 12, 2016,27166755,10.1001/jamadermatol.2016.1635,2509,English,http://www.ncbi.nlm.nih.gov/pubmed/27166755,,,,,,,,Pubmed,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,No,Comment/Editorial/Perspective/Letter,No,Yes,954,,
955,"Stamm, JAMA Dermatol, 2016",Stamm,"Stamm, L. V.",Zika Virus in the Americas: An Obscure Arbovirus Comes Calling,JAMA Dermatol,152,6,621-2,2016,2010-present,May 12, 2016,27167249,10.1001/jamadermatol.2016.1499,2554,English,http://www.ncbi.nlm.nih.gov/pubmed/27167249,"Department of Epidemiology, Program in Infectious Diseases, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill.",,,,,,,Pubmed,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,955,,
956,"WHO, , 2016",WHO,WHO,"Zika situation report. Zika virus, Microcephaly and Guillain-Barré syndrome - 12 May 2016",,,,,2016,2010-present,May 12, 2016,,,2674,,http://www.who.int/emergencies/zika-virus/situation-report/12-may-2016/en/,,Switzerland,Europe,,Public/Government,,,WHO,May 30, 2016,Yes,,No,"Zika, indirect evidence or other topic",Surveillance report or data,,,No,Yes,956,Clinical/epidemiological research,Ecological study/outbreak report
957,"Simoes, Rev Assoc Med Bras, 2016",Simoes,"Simoes, R.; Buzzini, R.; Bernardo, W.; Cardoso, F.; Salomao, A.; Cerri, G.",Zika virus infection and pregnancy,Rev Assoc Med Bras,62,2,108-15,2016,2010-present,May 12, 2016,27167538,10.1590/1806-9282.62.02.108,2518,English,http://www.ncbi.nlm.nih.gov/pubmed/27167538,"Federacao Brasileira das Associacoes de Ginecologia e Obstetricia, Brazil.; Associacao Medica Brasileira, Brazil.",,,,,,,Pubmed,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,957,,
958,"Epelboin, Bull Soc Pathol Exot, 2016",Epelboin,"Epelboin, L.; Douine, M.; Carles, G.; Villemant, N.; Nacher, M.; Rousset, D.; Djossou, F.; Mosnier, E.",[Zika virus outbreak in Latin America: what are the challenges for French Guiana in April 2016?],Bull Soc Pathol Exot,109,2,114-25,2016,2010-present,May 12, 2016,27167975,10.1007/s13149-016-0490-5,2369,French,http://www.ncbi.nlm.nih.gov/pubmed/27167975,"Unite des maladies infectieuses et tropicales, Centre hospitalier Andree Rosemon, Cayenne, Guyane francaise, France. epelboincrh@hotmail.fr.; Ecosystemes amazoniens et pathologie tropicale (EPAT).EA3593., Universite de la Guyane, Guyane Francaise, France. epelboincrh@hotmail.fr.; Ecosystemes amazoniens et pathologie tropicale (EPAT).EA3593., Universite de la Guyane, Guyane Francaise, France.; Centre d'investigation clinique Antilles-Guyane, Inserm 1424, Centre hospitalier Andree Rosemon, 97300, Cayenne, Guyane francaise, France.; Service de gynecologie obstetrique, Centre hospitalier de l'Ouest guyanais, Saint-Laurent-du-Maroni cedex, Guyane francaise, France.; Institut de geographie (UFR08), Universite Paris 1 Pantheon-Sorbonne University, Paris, France.; Centre nationale des arbovirus, laboratoire de virologie, Institut Pasteur de la Guyane, Cayenne, Guyane francaise, France.; Unite des maladies infectieuses et tropicales, Centre hospitalier Andree Rosemon, Cayenne, Guyane francaise, France.; Centres delocalises de preventions et de soins, Centre hospitalier Andree Rosemon, Cayenne, Guyane francaise, France.",,,,,French Guiana; Latin America; Maternal-fetal infections; Microcephaly; Sexually transmitted diseases; Zika virus,"Started in 2015 in Brazil, an outbreak linked to a little known arbovirus, Zika virus spread throughout Latin America. This virus, considered until recently as responsible of only mild symptoms, made mention of previously unsuspected complications, with severe neurological manifestations in adults and malformations of the central nervous system, including microcephaly, in newborns of mother infected during the pregnancy. While the continent is more accustomed to the succession of arbovirus epidemics, suspected complications and the many unknowns keys of the latter arriving raise many public health issues. French Guiana, a French territory located in the north-east of the continent, combines both European level of resources and climate and issues specific to the Amazon region and Latin America. We discuss here the issues for 2016 Zika virus epidemic in our region, many of them are generalizable to neighboring countries.",Pubmed,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Yes,Comment/Editorial/Perspective/Letter,No,Yes,958,,
959,"ECDC, 13.05.2016 updated on 17.05.2016, 2016",ECDC,ECDC,Epidemiological update. Outbreaks of Zika virus and complication potentially linked to the Zika virus infection - 13 May 2016,13.05.2016 updated on 17.05.2016,13.05.2016 updated on 17.05.2016,,,2016,2010-present,May 13, 2016,,,2215,,http://ecdc.europa.eu/en/press/news/_layouts/forms/News_DispForm.aspx?ID=1416&List=8db7286c-fe2d-476c-9133-18ff4cb1b568&Source=http%3A%2F%2Fecdc.europa.eu%2Fen%2Fhealthtopics%2Fzika_virus_infection%2FPages%2Fepidemiological-updates.aspx,,Sweden,Europe,,Public/Government,,,ECDC,May 30, 2016,Yes,,No,"Zika, indirect evidence or other topic",Surveillance report or data,,,No,Yes,959,Clinical/epidemiological research,Ecological study/outbreak report
960,"Armstrong, Am Fam Physician, 2016",Armstrong,"Armstrong, C.",CDC Updates Interim Guidance on Caring for Women with Possible Exposure to Zika Virus,Am Fam Physician,93,10,874-8,2016,2010-present,May 14, 2016,27175724,,2273,English,http://www.ncbi.nlm.nih.gov/pubmed/27175724,,,,,,,,Pubmed,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,960,,
961,"Bingham, MMWR Morb Mortal Wkly Rep, 2016",Bingham,"Bingham, A. M.; Cone, M.; Mock, V.; Heberlein-Larson, L.; Stanek, D.; Blackmore, C.; Likos, A.","Comparison of Test Results for Zika Virus RNA in Urine, Serum, and Saliva Specimens from Persons with Travel-Associated Zika Virus Disease - Florida, 2016",MMWR Morb Mortal Wkly Rep,65,18,475-8,2016,2010-present,May 14, 2016,27171533,10.15585/mmwr.mm6518e2,2318,English,http://www.ncbi.nlm.nih.gov/pubmed/27171533,Florida Department of Health.,,,,,,"In May 2015, Zika virus was reported to be circulating in Brazil. This was the first identified introduction of the virus in the Region of the Americas. Since that time, Zika virus has rapidly spread throughout the region. As of April 20, 2016, the Florida Department of Health Bureau of Public Health Laboratories (BPHL) has tested specimens from 913 persons who met state criteria for Zika virus testing. Among these 913 persons, 91 met confirmed or probable Zika virus disease case criteria and all cases were travel-associated (1). On the basis of previous small case studies reporting real time reverse-transcription polymerase chain reaction (RT-PCR) detection of Zika virus RNA in urine, saliva, and semen (2-6), the Florida Department of Health collected multiple specimen types from persons with suspected Zika virus disease. Test results were evaluated by specimen type and number of days after symptom onset to determine the most sensitive and efficient testing algorithm for acute Zika virus disease. Urine specimens were collected from 70 patients with suspected Zika virus disease from zero to 20 days after symptom onset. Of these, 65 (93%) tested positive for Zika virus RNA by RT-PCR. Results for 95% (52/55) of urine specimens collected from persons within 5 days of symptom onset tested positive by RT-PCR; only 56% (31/55) of serum specimens collected on the same date tested positive by RT-PCR. Results for 82% (9/11) of urine specimens collected >5 days after symptom onset tested positive by RT-PCR; none of the RT-PCR tests for serum specimens were positive. No cases had results that were exclusively positive by RT-PCR testing of saliva. BPHL testing results suggest urine might be the preferred specimen type to identify acute Zika virus disease.",Pubmed,May 30, 2016,Yes,,No,"Zika, not relevant to causality framework",Scientific (journal) article,No,Original research,No,Yes,961,Clinical/epidemiological research,Diagnostic study
962,"Ladner, Genome Announc, 2016",Ladner,"Ladner, J. T.; Wiley, M. R.; Prieto, K.; Yasuda, C. Y.; Nagle, E.; Kasper, M. R.; Reyes, D.; Vasilakis, N.; Heang, V.; Weaver, S. C.; Haddow, A.; Tesh, R. B.; Sovann, L.; Palacios, G.",Complete Genome Sequences of Five Zika Virus Isolates,Genome Announc,4,3,,2016,2010-present,May 14, 2016,27174284,10.1128/genomeA.00377-16,2453,English,http://www.ncbi.nlm.nih.gov/pubmed/27174284,"Center for Genome Sciences, U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland, USA.; U.S. Naval Medical Research Unit No. 2, Det Phnom Penh (NAMRU-2), Cambodia.; Naval Medical Research Center, Silver Spring, Maryland, USA.; Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, Texas, USA Department of Pathology, University of Texas Medical Branch, Galveston, Texas, USA Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, USA.; Division of Virology, U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland, USA.; Communicable Disease Centre, Cambodian Ministry of Health, Phnom Penh, Cambodia.; Center for Genome Sciences, U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland, USA gustavo.f.palacios.ctr@mail.mil.",,,,,,"Zika virus is an emerging human pathogen of great concern due to putative links to microcephaly and Guillain-Barre syndrome. Here, we report the complete genomes, including the 5' and 3' untranslated regions, of five Zika virus isolates, one from the Asian lineage and four from the African lineage.",Pubmed,May 30, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Original research,No,Yes,962,Basic and applied biomedical research,Sequence analysis and phylogenetics
963,"Ellison, Genome Announc, 2016",Ellison,"Ellison, D. W.; Ladner, J. T.; Buathong, R.; Alera, M. T.; Wiley, M. R.; Hermann, L.; Rutvisuttinunt, W.; Klungthong, C.; Chinnawirotpisan, P.; Manasatienkij, W.; Melendrez, M. C.; Maljkovic Berry, I.; Thaisomboonsuk, B.; Ong-Ajchaowlerd, P.; Kaneechit, W.; Velasco, J. M.; Tac-An, I. A.; Villa, D.; Lago, C. B.; Roque, V. G., Jr.; Plipat, T.; Nisalak, A.; Srikiatkhachorn, A.; Fernandez, S.; Yoon, I. K.; Haddow, A. D.; Palacios, G. F.; Jarman, R. G.; Macareo, L. R.",Complete Genome Sequences of Zika Virus Strains Isolated from the Blood of Patients in Thailand in 2014 and the Philippines in 2012,Genome Announc,4,3,,2016,2010-present,May 14, 2016,27174274,10.1128/genomeA.00359-16,2379,English,http://www.ncbi.nlm.nih.gov/pubmed/27174274,"Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand damon.ellison.mil@afrims.org.; Center for Genome Sciences, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland, USA.; Department of Disease Control, Bureau of Epidemiology, Ministry of Public Health, Nonthaburi, Thailand.; Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand.; Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.; Cebu City Health Department, Cebu City, Philippines.; Department of Health, Manila, Philippines.; University of Massachusetts Medical School, Worcester, Massachusetts, USA.; United States Army Medical Materiel Development Activity, Frederick, Maryland, USA.; International Vaccine Institute, Seoul, Republic of Korea.",,,,,,"Here, we present the complete genome sequences of two Zika virus (ZIKV) strains, Zika virus/Homo sapiens-tc/THA/2014/SV0127-14 and Zika virus/H. sapiens-tc/PHL/2012/CPC-0740, isolated from the blood of patients collected in Thailand, 2014, and the Philippines, 2012, respectively. Sequencing and phylogenetic analysis showed that both strains belong to the Asian lineage.",Pubmed,May 30, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Original research,No,Yes,963,Basic and applied biomedical research,Sequence analysis and phylogenetics
964,"Berlin, Tex Med, 2016",Berlin,"Berlin, J.",Don't Curb Your Enthusiasm,Tex Med,112,5,57-62,2016,2010-present,May 14, 2016,27175927,,2303,English,http://www.ncbi.nlm.nih.gov/pubmed/27175927,,,,,,,"The Texas Department of State Health Services Commissioner John Hellerstedt, MD, talks about his assessment of the state health department, how medicine can help the agency achieve its public health mission, and the challenges involved in Zika virus.",Pubmed,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,964,,
965,"Di Luca, Eurosurveillance, 2016",Di Luca,"Di Luca, M.; Severini, F.; Toma, L.; Boccolini, D.; Romi, R.; Remoli, M. E.; Sabbatucci, M.; Rizzo, C.; Venturi, G.; Rezza, G.; Fortuna, C.",Experimental studies of susceptibility of Italian Aedes albopictus to Zika virus,Eurosurveillance,21,18,,2016,2010-present,May 14, 2016,27171034,10.2807/1560-7917.ES.2016.21.18.30223,2308,English,http://www.ncbi.nlm.nih.gov/pubmed/27171034,"Unit of Vector-borne Diseases and International Health, Department of Infectious, Parasitic and Immune-Mediated Diseases, Istituto Superiore di Sanita, Rome, Italy.",,,,,Aedes aegypti; Aedes albopictus; Italian; Vector competence; experimental infection; zika virus,"We report a study on vector competence of an Italian population of Aedes albopictus for Zika virus (ZIKV). Ae. albopictus was susceptible to ZIKV infection (infection rate: 10%), and the virus could disseminate and was secreted in the mosquito's saliva (dissemination rate: 29%; transmission rate: 29%) after an extrinsic incubation period of 11 days. The observed vector competence was lower than that of an Ae. aegypti colony tested in parallel.",Pubmed,May 30, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Original research,No,Yes,965,Environmental and vector research,Vector competence studies
966,"Rasmussen, Cell Host Microbe, 2016",Rasmussen,"Rasmussen, A. L.; Katze, M. G.",Genomic Signatures of Emerging Viruses: A New Era of Systems Epidemiology,Cell Host Microbe,19,5,611-8,2016,2010-present,May 14, 2016,27173929,10.1016/j.chom.2016.04.016,2560,English,http://www.ncbi.nlm.nih.gov/pubmed/27173929,"Department of Microbiology, University of Washington, 960 Republican Street, Seattle, WA 98109, USA.; Department of Microbiology, University of Washington, 960 Republican Street, Seattle, WA 98109, USA. Electronic address: honey@uw.edu.",,,,,,"Compared to classical epidemiologic methods, genomics can be used to precisely monitor virus evolution and transmission in real time across large, diverse populations. Integration of pathogen genomics with data about host genetics and global transcriptional responses to infection allows for comprehensive studies of population-level responses to infection and provides novel methods for predicting clinical outcomes. As genomic technologies become more accessible, these methods will redefine how emerging viruses are studied and outbreaks are contained. Here we review the existing and emerging genomic technologies that are enabling systems epidemiology and systems virology and making it possible to respond rapidly to emerging viruses such as Zika.",Pubmed,May 30, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Yes,Review,No,Yes,966,Clinical/epidemiological research,Epidemiological/clinical review
967,"Cohen, Science, 2016",Cohen,"Cohen, J.",INFECTIOUS DISEASE. Animals show how Zika harms fetuses,Science,352,6287,752-3,2016,2010-present,May 14, 2016,27174964,10.1126/science.352.6287.752,2285,English,http://www.ncbi.nlm.nih.gov/pubmed/27174964,,,,,,"Abortion, Spontaneous/virology; Animals; Brain/abnormalities/pathology/virology; Disease Models, Animal; Female; Fetus/abnormalities/*pathology/*virology; Haplorhini; Mice; Placenta/*virology; Pregnancy; Ultrasonography, Prenatal; Zika Virus/*pathogenicity; Zika Virus Infection/*complications/pathology",,Pubmed,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,News item or lay press,,,No,Yes,967,,
968,"Bozza, Intensive Care Med, 2016",Bozza,"Bozza, F. A.; Grinsztejn, B.",Key points on Zika infection for the intensivist,Intensive Care Med,,,,2016,2010-present,May 14, 2016,27172823,10.1007/s00134-016-4378-4,2296,English,http://www.ncbi.nlm.nih.gov/pubmed/27172823,"Intensive Care Lab, Instituto Nacional de Infectologia Evandro Chagas (INI), Fundacao Oswaldo Cruz (FIOCRUZ), Av. Brasil 4365, Rio De Janeiro, RJ, 21045-900, Brazil. fernando.bozza@ini.fiocruz.br.; HIV Lab, Instituto Nacional de Infectologia Evandro Chagas (INI), Fundacao Oswaldo Cruz (FIOCRUZ), Rio De Janeiro, Brazil.",,,,,,,Pubmed,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,968,,
969,"Lorenzi, MMWR Morb Mortal Wkly Rep, 2016",Lorenzi,"Lorenzi, O. D.; Major, C.; Acevedo, V.; Perez-Padilla, J.; Rivera, A.; Biggerstaff, B. J.; Munoz-Jordan, J.; Waterman, S.; Barrera, R.; Sharp, T. M.","Reduced Incidence of Chikungunya Virus Infection in Communities with Ongoing Aedes Aegypti Mosquito Trap Intervention Studies - Salinas and Guayama, Puerto Rico, November 2015-February 2016",MMWR Morb Mortal Wkly Rep,65,18,479-80,2016,2010-present,May 14, 2016,27171600,10.15585/mmwr.mm6518e3,2415,English,http://www.ncbi.nlm.nih.gov/pubmed/27171600,,,,,,,"Aedes species mosquitoes transmit chikungunya virus, as well as dengue and Zika viruses, and bite most often during the day.* Infectious mosquito bites frequently occur in and around homes (1,2). Caribbean countries first reported local transmission of chikungunya virus in December 2013, and soon after, chikungunya virus spread throughout the Americas (3). Puerto Rico reported its first laboratory-positive chikungunya case in May 2014 (4), and subsequently identified approximately 29,000 suspected cases throughout the island by the end of 2015.(dagger) Because conventional vector control approaches often fail to result in effective and sustainable prevention of infection with viruses transmitted by Aedes mosquitoes (5), and to improve surveillance of mosquito population densities, CDC developed an Autocidal Gravid Ovitrap (AGO) (6) to attract and capture the female Aedes aegypti mosquitoes responsible for transmission of infectious agents to humans (Figure). The AGO trap is a simple, low-cost device that requires no use of pesticides and no servicing for an extended period of time (6).",Pubmed,May 30, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,No,Original research,No,Yes,969,Environmental and vector research,Other ecological
970,"Wong, J Formos Med Assoc, 2016",Wong,"Wong, S. S.",Reply to comments on 'Zika virus transmission: What to concern on its transmission apart from mosquito control' by Viroj Wiwanitkit,J Formos Med Assoc,,,,2016,2010-present,May 14, 2016,27174386,10.1016/j.jfma.2016.03.007,2645,English,http://www.ncbi.nlm.nih.gov/pubmed/27174386,"Department of Microbiology, Research Centre for Infection and Immunology, Faculty of Medicine, The University of Hong Kong, Hong Kong. Electronic address: samsonsy@hku.hk.",,,,,,,Pubmed,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,No,Comment/Editorial/Perspective/Letter,No,Yes,970,,
971,"Xie, Cell Host Microbe, 2016",Xie,"Xie, X.; Shan, C.; Shi, P. Y.",Restriction of Zika Virus by Host Innate Immunity,Cell Host Microbe,19,5,566-7,2016,2010-present,May 14, 2016,27173920,10.1016/j.chom.2016.04.019,2575,English,http://www.ncbi.nlm.nih.gov/pubmed/27173920,"Departments of Biochemistry & Molecular Biology and Pharmacology & Toxicology, and Sealy Center for Structural Biology & Molecular Biophysics, University of Texas Medical Branch, Galveston, TX 77555, USA.; Departments of Biochemistry & Molecular Biology and Pharmacology & Toxicology, and Sealy Center for Structural Biology & Molecular Biophysics, University of Texas Medical Branch, Galveston, TX 77555, USA. Electronic address: peshi@utmb.edu.",,,,,,"Recent epidemics of Zika virus (ZIKV) have brought increasing concerns of heightened disease severity and neurotropism. In this issue of Cell Host & Microbe, Lazear et al. (2016) and Bayer et al. (2016) show that innate immunity can restrict ZIKV infection and disease development.",Pubmed,May 30, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,971,,
972,"Tian, Protein Cell, 2016",Tian,"Tian, H.; Ji, X.; Yang, X.; Xie, W.; Yang, K.; Chen, C.; Wu, C.; Chi, H.; Mu, Z.; Wang, Z.; Yang, H.",The crystal structure of Zika virus helicase: basis for antiviral drug design,Protein Cell,7,6,450-4,2016,2010-present,May 14, 2016,27172988,10.1007/s13238-016-0275-4,2500,English,http://www.ncbi.nlm.nih.gov/pubmed/27172988,"School of Life Sciences, Tianjin University, Tianjin, 300072, China.; Tianjin International Joint Academy of Biotechnology and Medicine, Tianjin, 300457, China.; The State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, 210023, China.; Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, 44195, USA.; School of Life Sciences, Tianjin University, Tianjin, 300072, China. yanght@tju.edu.cn.; Tianjin International Joint Academy of Biotechnology and Medicine, Tianjin, 300457, China. yanght@tju.edu.cn.",,,,,,,Pubmed,May 30, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Original research,No,Yes,972,Basic and applied biomedical research,Biochemical/protein structure studies
973,"Wu, Cell Res, 2016",Wu,"Wu, K. Y.; Zuo, G. L.; Li, X. F.; Ye, Q.; Deng, Y. Q.; Huang, X. Y.; Cao, W. C.; Qin, C. F.; Luo, Z. G.",Vertical transmission of Zika virus targeting the radial glial cells affects cortex development of offspring mice,Cell Res,26,6,645-54,2016,2010-present,May 14, 2016,27174054,10.1038/cr.2016.58,2618,English,http://www.ncbi.nlm.nih.gov/pubmed/27174054,"Institute of Neuroscience, State Key Laboratory of Neuroscience, Shanghai Institutes for Biological Sciences, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai 200031, China.; Chinese Academy of Sciences University, Beijing, China.; Department of Virology, State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China.; ShanghaiTech University, Shanghai, China.",China,Asia,China,Mixed,,"The recent Zika virus (ZIKV) epidemic in Latin America coincided with a marked increase in microcephaly in newborns. However, the causal link between maternal ZIKV infection and malformation of the fetal brain has not been firmly established. Here we show a vertical transmission of ZIKV in mice and a marked effect on fetal brain development. We found that intraperitoneal (i.p.) injection of a contemporary ZIKV strain in pregnant mice led to the infection of radial glia cells (RGs) of dorsal ventricular zone of the fetuses, the primary neural progenitors responsible for cortex development, and caused a marked reduction of these cortex founder cells in the fetuses. Interestingly, the infected fetal mice exhibited a reduced cavity of lateral ventricles and a discernable decrease in surface areas of the cortex. This study thus supports the conclusion that vertically transmitted ZIKV affects fetal brain development and provides a valuable animal model for the evaluation of potential therapeutic or preventative strategies.",Pubmed,May 30, 2016,Yes,,Yes,,Scientific (journal) article,Yes,Original research,No,Yes,973,Basic and applied biomedical research,Animal experiment
974,", Br Dent J, 2016",,,Zika fever and congenital Zika syndrome: an unexpected emerging arboviral disease,Br Dent J,220,9,449,2016,2010-present,May 14, 2016,27173701,10.1038/sj.bdj.2016.330,2366,English,http://www.ncbi.nlm.nih.gov/pubmed/27173701,,,,,,,'...detected in breast milk and saliva of infected women...' although 'further studies are needed to determine the risk of ZIKV transmission by...saliva.',Pubmed,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,974,,
975,"Ong, Intern Med J, 2016",Ong,"Ong, C. W.",Zika virus: an emerging infectious threat,Intern Med J,46,5,525-30,2016,2010-present,May 14, 2016,27170237,10.1111/imj.13059,2550,English,http://www.ncbi.nlm.nih.gov/pubmed/27170237,"Microbiology Department, The Canberra HospitalCanberra, Australian Capital Territory, Australia.",,,,,,,Pubmed,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,975,,
976,"Musso, Blood Transfus, 2016",Musso,"Musso, D.; Aubry, M.; Broult, J.; Stassinopoulos, A.; Green, J.","Zika virus: new emergencies, potential for severe complications, and prevention of transfusion-transmitted Zika fever in the context of co-circulation of arboviruses",Blood Transfus,,,01. Feb,2016,2010-present,May 14, 2016,27177409,10.2450/2016.0003-16,2507,English,http://www.ncbi.nlm.nih.gov/pubmed/27177409,"Unit of Emerging Infectious Diseases, 'Institut Louis Malarde', Tahiti, Polynesie Francaise, United States of America.; Blood Centre, Taone Hospital, Pirae, Polynesie Francaise, United States of America.; Cerus Corporation, Global Scientific Affairs, San Francisco, CA, United States of America.",,,,,,,Pubmed,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,976,,
977,"Speciale, Pract Midwife, 2016",Speciale,"Speciale, A. M.",Zika: an opportunity for change in Latin America?,Pract Midwife,19,4,6,2016,2010-present,May 14, 2016,27172672,,2476,English,http://www.ncbi.nlm.nih.gov/pubmed/27172672,,,,,,Female; Humans; Latin America; Nurse Midwives/*standards; *Social Change; Women's Health/*standards; Women's Rights/*standards; Zika Virus Infection/*nursing,,Pubmed,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,977,,
978,"Sahiner, Mikrobiyol Bul, 2016",Sahiner,"Sahiner, F.",[Global spread of Zika virus epidemic: current knowledges and uncertainties],Mikrobiyol Bul,50,2,333-51,2016,2010-present,May 14, 2016,27175508,,2498,Other,http://www.ncbi.nlm.nih.gov/pubmed/27175508,"Gulhane Military Medical Academy, Department of Medical Microbiology, Ankara, Turkey. fsvirol@gmail.com.",,,,,,"Zika virus (ZIKV) is an enveloped RNA virus that belongs to the Flaviviridae family. Although more than 60 years have passed since the discovery and first reported human cases of the virus, only a small number (< 10) of cases had been encountered in the literature until the last 10 years. Zika virus was known as a virus which caused sporadic infections and was confined to Africa and Asia along a narrow equatorial line. In 2007, however, the first major outbreak of ZIKV occurred in Yap Island (Micronesia), and so it was reported for the first time outside of Africa and Asia. Between the years of 2007 and 2014, ZIKV spreaded to island groups located in Southeast Asia and the Pacific Ocean, and in 2015-2016, it has spread to South and Central America and the Caribbean. Today, travel-related imported cases is still been reported in Europe, North America, and other countries in the Far East. According to the data from the World Health Organization and the Centers for Disease Control and Prevention, as of March 2016, ZIKV infections have already spread locally in more than 30 countries, and travel alerts have been issued for the countries where the virus is present. Zika virus infections are generally asymptomatic or may present with a moderate clinical picture (e.g. acute onset of fever, maculopapular rash, arthralgia, and nonpurulent conjunctivitis). Although no deaths were attributed to ZIKV infection over the past 60 years, as of November 2015, it has been suggested that three deaths in Brazil, including the death of a newborn with microcephaly, may be attributed to ZIKV infection. In addition, concurrent with outbreaks in 2013 in French Polynesia and in 2015 in Brazil, there have been significant rises reported in the incidence of some autoimmune and neurodevelopmental disorders, including Guillain-Barre syndrome and microcephaly; these reports have caused considerable international concern. There are many points that are still unclear about ZIKV, including: (1) intrauterine transmission risk, frequency, and effects of the infection on fetal development; (2) the probability of perinatal transmission and if so the possible risks; (3) association with autoimmune and neurological diseases, and presence of long-term sequelae risks after infection; (4) possible routes of transmission other than mosquito bites, such as sexual contact, blood transfusion, and other body fluids (saliva, semen, or urine); (5) presence of reservoir(s) and different mosquito vectors; (6) diagnostic difficulties including cross reactivity in serological tests and standardization of testing procedures; (7) severity of the infection in immunocompromised patients; and (8) the potential effectiveness of antiviral therapy or preventive vaccines. In this review, updated information and recommendations regarding ZIKV outbreaks and risks, and the epidemiology, diagnosis and characteristics of ZIKV infections, are summarized in light of the most recent literature.",Pubmed,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,978,,
979,"The Lancet Infectious, Lancet Infect Dis, 2016",The Lancet Infectious,"The Lancet Infectious, Diseases",Zika virus at the games: is it safe?,Lancet Infect Dis,16,6,619,2016,2010-present,May 15, 2016,27177718,10.1016/S1473-3099(16)30069-X,2566,English,http://www.ncbi.nlm.nih.gov/pubmed/27177718,,,,,,,,Pubmed,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,979,,
980,", Wkly Epidemiol Rec, 2016",,,Epidemic focus. Waiting in the wings: Aedes mosquitoes and flavivirus epidemics,Wkly Epidemiol Rec,91,19,249-50,2016,2010-present,May 18, 2016,27187993,,2269,French,http://www.ncbi.nlm.nih.gov/pubmed/27187993,,,,,,"Adaptation, Physiological; Aedes/physiology/*virology; Animals; Climate Change; Epidemics/*statistics & numerical data; Humans; Insect Vectors/physiology/*virology; Mosquito Control/methods; Urbanization; Yellow Fever/*epidemiology/transmission; Zika Virus Infection/*epidemiology/transmission",,Pubmed,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,980,,
981,"Zhang, Lancet Infect Dis, 2016",Zhang,"Zhang, F. C.; Li, X. F.; Deng, Y. Q.; Tong, Y. G.; Qin, C. F.",Excretion of infectious Zika virus in urine,Lancet Infect Dis,16,6,641-2,2016,2010-present,May 18, 2016,27184420,10.1016/S1473-3099(16)30070-6,2587,English,http://www.ncbi.nlm.nih.gov/pubmed/27184420,"Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China.; Department of Virology, Beijing Institute of Microbiology and Epidemiology, Beijing, China.; State Key Laboratory of Pathogen and Biosecurity, Beijing, China.; Department of Virology, Beijing Institute of Microbiology and Epidemiology, Beijing, China; State Key Laboratory of Pathogen and Biosecurity, Beijing, China. Electronic address: qincf@bmi.ac.cn.",,,,,,,Pubmed,May 30, 2016,Yes,,No,"Zika, not relevant to causality framework",Scientific (journal) article,Yes,Original research,No,Yes,981,Clinical/epidemiological research,Case report
982,"Grigoraki, Insect Biochem Mol Biol, 2016",Grigoraki,"Grigoraki, L.; Balabanidou, V.; Meristoudis, C.; Miridakis, A.; Ranson, H.; Swevers, L.; Vontas, J.","Functional and immunohistochemical characterization of CCEae3a, a carboxylesterase associated with temephos resistance in the major arbovirus vectors Aedes aegypti and Ae. albopictus",Insect Biochem Mol Biol,74,,61-7,2016,2010-present,May 18, 2016,27180726,10.1016/j.ibmb.2016.05.007,2384,English,http://www.ncbi.nlm.nih.gov/pubmed/27180726,"Department of Biology, University of Crete, Vassilika Vouton, 73100 Heraklion, Greece; Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, 73100 Heraklion, Greece.; Insect Molecular Genetics and Biotechnology, Institute of Biosciences and Applications, National Centre for Scientific Research 'Demokritos', Athens, Greece.; Environmental Chemical Processes Laboratory (ECPL), Department of Chemistry, University of Crete, 71003 Heraklion, Greece.; Department of Vector Biology, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, UK.; Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, 73100 Heraklion, Greece; Pesticide Science Laboratory, Department of Crop Science, Agricultural University of Athens, 11855 Athens, Greece. Electronic address: vontas@imbb.forth.gr.",,,,,Aedes; Arbovirus; Detoxification; Diagnostics; Insecticide resistance,"Temephos is a major organophosphate (OP) larvicide that has been used extensively for the control of Aedes albopictus and Aedes aegypti, the major vectors for viral diseases, such as dengue fever, zika and chikungunya. Resistance to temephos has been recently detected and associated with the upregulation of carboxylesterases (CCEs) through gene amplification, in both species. Here, we expressed the CCEae3a genes which showed the most striking up-regulation in resistant Aedes strains, using the baculovirus system. All CCEae3a variants encoded functional enzymes, with high activity and preference for p-nitrophenyl butyrate, a substrate that was shown capable to differentiate temephos resistant from susceptible Aedes larvae. Enzyme kinetic studies showed that CCEae3as from both Ae. aegypti and Ae. albopictus (CCEae3a_aeg and CCEae3a_alb, respectively) strongly interact with temephos oxon and slowly released the OP molecule, indicating a sequestration resistance mechanism. No difference was detected between resistant and susceptible CCEae3a_aeg variants (CCEae3a_aegR and CCEae3a_aegS, respectively), indicating that previously reported polymorphism is unlikely to play a role in temephos resistance. HPLC/MS showed that CCEae3as were able to metabolize temephos oxon to the temephos monoester [(4-hydroxyphenyl) sulfanyl] phenyl O,O-dimethylphosphorothioate. Western blot and immunolocalization studies, based on a specific antibody raised against the CCEae3a_alb showed that the enzyme is expressed at higher levels in resistant insects, primarily in malpighian tubules (MT) and nerve tissues.",Pubmed,May 30, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Original research,No,Yes,982,Environmental and vector research,Vector control studies
983,"Orsborne, PLoS One, 2016",Orsborne,"Orsborne, J.; DeRaedt Banks, S.; Hendy, A.; Gezan, S. A.; Kaur, H.; Wilder-Smith, A.; Lindsay, S. W.; Logan, J. G.","Personal Protection of Permethrin-Treated Clothing against Aedes aegypti, the Vector of Dengue and Zika Virus, in the Laboratory",PLoS One,11,5,e0152805,2016,2010-present,May 18, 2016,27187593,10.1371/journal.pone.0152805,2551,English,http://www.ncbi.nlm.nih.gov/pubmed/27187593,"Department of Disease Control, London School of Hygiene and Tropical Medicine, London, United Kingdom.; arctec, London School of Hygiene and Tropical Medicine, London, United Kingdom.; SFRC, University of Florida, Gainesville, Florida, United States of America.; Department of Global Health and Epidemiology, Umea University, Umea, Sweden.; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.; School of Biological and Biomedical Sciences, Durham University, Durham, United Kingdom.",,,,,,"BACKGROUND: The dengue and Zika viruses are primarily transmitted by Aedes aegypti mosquitoes, which are most active during day light hours and feed both in and outside of the household. Personal protection technologies such as insecticide-treated clothing could provide individual protection. Here we assessed the efficacy of permethrin-treated clothing on personal protection in the laboratory. METHODS: The effect of washing on treated clothing, skin coverage and protection against resistant and susceptible Ae. aegypti was assessed using modified WHO arm-in-cage assays. Coverage was further assessed using free-flight room tests to investigate the protective efficacy of unwashed factory-dipped permethrin-treated clothing. Clothing was worn as full coverage (long sleeves and trousers) and partial coverage (short sleeves and shorts). Residual permethrin on the skin and its effect on mosquitoes was measured using modified WHO cone assays and quantified using high-pressure liquid chromatography (HPLC) analysis. RESULTS: In the arm-in-cage assays, unwashed clothing reduced landing by 58.9% (95% CI 49.2-66.9) and biting by 28.5% (95% CI 22.5-34.0), but reduced to 18.5% (95% CI 14.7-22.3) and 11.1% (95% CI 8.5-13.8) respectively after 10 washes. Landing and biting for resistant and susceptible strains was not significantly different (p<0.05). In free-flight room tests, full coverage treated clothing reduced landing by 24.3% (95% CI 17.4-31.7) and biting by 91% (95% CI 82.2-95.9) with partial coverage reducing landing and biting by 26.4% (95% CI 20.3-31.2) and 49.3% (95% CI 42.1-59.1) respectively with coverage type having no significant difference on landing (p<0.05). Residual permethrin was present on the skin in low amounts (0.0041mg/cm2), but still produced a KD of >80% one hour after wearing treated clothing. CONCLUSION: Whilst partially covering the body with permethrin-treated clothing provided some protection against biting, wearing treated clothing with long sleeves and trousers provided the highest form of protection. Washing treated clothing dramatically reduced protection provided. Permethrin-treated clothing could provide protection to individuals from Ae. aegypti that show permethrin resistance. Additionally, it could continue to provide protection even after the clothing has been worn. Field trials are urgently needed to determine whether clothing can protect against dengue and Zika.",Pubmed,May 30, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Original research,No,Yes,983,Environmental and vector research,Vector control studies
984,"Waggoner, Emerg Infect Dis, 2016",Waggoner,"Waggoner, J. J.; Gresh, L.; Mohamed-Hadley, A.; Ballesteros, G.; Davila, M. J.; Tellez, Y.; Sahoo, M. K.; Balmaseda, A.; Harris, E.; Pinsky, B. A.","Single-Reaction Multiplex Reverse Transcription PCR for Detection of Zika, Chikungunya, and Dengue Viruses",Emerg Infect Dis,22,7,1295-7,2016,2010-present,May 18, 2016,27184629,10.3201/eid2207.160326,2537,English,http://www.ncbi.nlm.nih.gov/pubmed/27184629,,,,,,Zika virus; arboviruses; chikungunya virus; dengue virus; multiplex molecular diagnostics; real-time RT-PCR; vector-borne infections; viruses,"Clinical manifestations of Zika virus, chikungunya virus, and dengue virus infections can be similar. To improve virus detection, streamline molecular workflow, and decrease test costs, we developed and evaluated a multiplex real-time reverse transcription PCR for these viruses.",Pubmed,May 30, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Original research,No,Yes,984,Clinical/epidemiological research,Diagnostic study
985,"Li, Cell Stem Cell, 2016",Li,"Li, C.; Xu, D.; Ye, Q.; Hong, S.; Jiang, Y.; Liu, X.; Zhang, N.; Shi, L.; Qin, C. F.; Xu, Z.",Zika Virus Disrupts Neural Progenitor Development and Leads to Microcephaly in Mice,Cell Stem Cell,,,,2016,2010-present,May 18, 2016,27179424,10.1016/j.stem.2016.04.017,2455,English,http://www.ncbi.nlm.nih.gov/pubmed/27179424,"State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100101, China.; Institute of Life Sciences, Fuzhou University, Fuzhou 350116, China.; Department of Virology, State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China.; State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China.; Department of Virology, State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China; Guangxi Medical University, Nanning 530021, China.; Department of Virology, State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China. Electronic address: qincf@bmi.ac.cn.; State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China; Parkinson's Disease Center, Beijing Institute for Brain Disorders, Beijing 100101, China. Electronic address: zhxu@genetics.ac.cn.",China,Asia,China,Public/Government,,"The link between Zika virus (ZIKV) infection and microcephaly has raised urgent global alarm. The historical African ZIKV MR766 was recently shown to infect cultured human neural precursor cells (NPCs), but unlike the contemporary ZIKV strains, it is not believed to cause microcephaly. Here we investigated whether the Asian ZIKV strain SZ01 could infect NPCs in vivo and affect brain development. We found that SZ01 replicates efficiently in embryonic mouse brain by directly targeting different neuronal linages. ZIKV infection leads to cell-cycle arrest, apoptosis, and inhibition of NPC differentiation, resulting in cortical thinning and microcephaly. Global gene expression analysis of infected brains reveals upregulation of candidate flavirus entry receptors and dysregulation of genes associated with immune response, apoptosis, and microcephaly. Our model provides evidence for a direct link between Zika virus infection and microcephaly, with potential for further exploration of the underlying mechanisms and management of ZIKV-related pathological effects during brain development.",Pubmed,May 30, 2016,Yes,,Yes,,Scientific (journal) article,Yes,Original research,No,Yes,985,Basic and applied biomedical research,Animal experiment
986,"Miner, Cell, 2016",Miner,"Miner, J. J.; Cao, B.; Govero, J.; Smith, A. M.; Fernandez, E.; Cabrera, O. H.; Garber, C.; Noll, M.; Klein, R. S.; Noguchi, K. K.; Mysorekar, I. U.; Diamond, M. S.",Zika Virus Infection during Pregnancy in Mice Causes Placental Damage and Fetal Demise,Cell,165,5,1081-91,2016,2010-present,May 18, 2016,27180225,10.1016/j.cell.2016.05.008,2485,English,http://www.ncbi.nlm.nih.gov/pubmed/27180225,"Department of Medicine, Washington University School of Medicine, Saint Louis, MO 63110, USA.; Department of Obstetrics and Gynecology, Washington University School of Medicine, Saint Louis, MO 63110, USA.; Department of Medicine, Washington University School of Medicine, Saint Louis, MO 63110, USA; Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA.; Department of Psychiatry, Washington University School of Medicine, Saint Louis, MO 63110, USA.; Department of Medicine, Washington University School of Medicine, Saint Louis, MO 63110, USA; Department of Anatomy and Neurobiology, Washington University School of Medicine, Saint Louis, MO 63110, USA; Department of Molecular Microbiology, Washington University School of Medicine, Saint Louis, MO 63110, USA; Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA.; Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA; Department of Obstetrics and Gynecology, Washington University School of Medicine, Saint Louis, MO 63110, USA. Electronic address: mysorekari@wudosis.wustl.edu.; Department of Medicine, Washington University School of Medicine, Saint Louis, MO 63110, USA; Department of Molecular Microbiology, Washington University School of Medicine, Saint Louis, MO 63110, USA; Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA; The Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, Saint Louis, MO 63110, USA. Electronic address: diamond@borcim.wustl.edu.",United States,Americas,United States,Mixed,,"Zika virus (ZIKV) infection in pregnant women causes intrauterine growth restriction, spontaneous abortion, and microcephaly. Here, we describe two mouse models of placental and fetal disease associated with in utero transmission of ZIKV. Female mice lacking type I interferon signaling (Ifnar1(-/-)) crossed to wild-type (WT) males produced heterozygous fetuses resembling the immune status of human fetuses. Maternal inoculation at embryonic day 6.5 (E6.5) or E7.5 resulted in fetal demise that was associated with ZIKV infection of the placenta and fetal brain. We identified ZIKV within trophoblasts of the maternal and fetal placenta, consistent with a trans-placental infection route. Antibody blockade of Ifnar1 signaling in WT pregnant mice enhanced ZIKV trans-placental infection although it did not result in fetal death. These models will facilitate the study of ZIKV pathogenesis, in utero transmission, and testing of therapies and vaccines to prevent congenital malformations.",Pubmed,May 30, 2016,Yes,,Yes,,Scientific (journal) article,Yes,Original research,No,Yes,986,Basic and applied biomedical research,Animal experiment
987,"Beckham, JAMA Neurol, 2016",Beckham,"Beckham, J. D.; Pastula, D. M.; Massey, A.; Tyler, K. L.",Zika Virus as an Emerging Global Pathogen: Neurological Complications of Zika Virus,JAMA Neurol,,,,2016,2010-present,May 18, 2016,27183312,10.1001/jamaneurol.2016.0800,2335,English,http://www.ncbi.nlm.nih.gov/pubmed/27183312,"Neuro-Infectious Disease Group, Department of Neurology, University of Colorado School of Medicine, Aurora2Division of Infectious Diseases, Department of Medicine, University of Colorado School of Medicine, Aurora.; Neuro-Infectious Disease Group, Department of Neurology, University of Colorado School of Medicine, Aurora.; Division of Infectious Diseases, Department of Medicine, University of Colorado School of Medicine, Aurora.",,,,,,"Importance: Zika virus (ZIKV) is an emerging arthropod-borne virus (arbovirus) in the genus Flavivirus that has caused a widespread outbreak of febrile illness, is associated with neurological disease, and has spread across the Pacific to the Americas in a short period. Observations: In this review, we discuss what is currently known about ZIKV, neuroimmunologic complications, and the impact on global human health. Zika virus spread across Africa and Asia in part owing to unique genomic evolutionary conditions and pressures resulting in specific human disease manifestations, complications, and pathogenesis. Recent data suggest that acute ZIKV infection in pregnant women may result in acute infection of fetal tissue and brain tissue, causing microcephaly and potentially severe debilitation of the infant or even death of the fetus. Cases of acute ZIKV are also associated with Guillain-Barre syndrome. With the increased number of cases, new complications such as ocular involvement and sexual transmission have been reported. Conclusions and Relevance: Zika virus is an emerging viral pathogen with significant consequences on human health throughout the world. Ongoing research into this pathogen is urgently needed to produce viable vaccine and therapeutic options.",Pubmed,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Yes,Review,No,Yes,987,Clinical/epidemiological research,Epidemiological/clinical review
988,"Ribeiro, Curr Opin Virol, 2016",Ribeiro,"Ribeiro, L. S.; Marques, R. E.; Jesus, A. M.; Almeida, R. P.; Teixeira, M. M.",Zika crisis in Brazil: challenges in research and development,Curr Opin Virol,18,,76-81,2016,2010-present,May 18, 2016,27179929,10.1016/j.coviro.2016.04.002,2522,English,http://www.ncbi.nlm.nih.gov/pubmed/27179929,"Department of Microbiology, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil; Immunopharmacology, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.; Immunopharmacology, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.; Laboratorio de Biologia Molecular and Programa de Pos Graduacao em Ciencias da Saude, Hospital Universitario, Universidade Federal de Sergipe, Aracaju, Brazil.; Immunopharmacology, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil. Electronic address: mmtex@icb.ufmg.br.",,,,,,"Infection with the Zika virus (ZIKV) usually causes a mild acute illness, but two major severe syndromes have been described during the epidemic in Brazil: microcephaly and the Guillain-Barre Syndrome. There is now much evidence to show that ZIKV can infect and damage neuronal cells in vitro. In experimental animals, ZIKV has significant neurotropism and can cause brain damage. At present, diagnosis is still a challenge in the field and there is no treatment available. Another major challenge is that one must devise therapies for pregnant women, at all stages of pregnancy. Devising adequate treatment for ZIKV infections represents a challenge that will only be met by the joint effort of the research community.",Pubmed,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,988,,
989,"Blonz, Lancet Infect Dis, 2016",Blonz,"Blonz, E. R.",Zika virus and GLUT1,Lancet Infect Dis,16,6,642,2016,2010-present,May 18, 2016,27184421,10.1016/S1473-3099(16)30062-7,2354,English,http://www.ncbi.nlm.nih.gov/pubmed/27184421,"Department of Clinical Pharmacy, University of California, San Francisco, CA 94143, USA. Electronic address: er@blonz.com.",,,,,,,Pubmed,May 30, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,989,,
990,"Liuzzi, Eur J Intern Med, 2016",Liuzzi,"Liuzzi, G.; Nicastri, E.; Puro, V.; Zumla, A.; Ippolito, G.",Zika virus in saliva-New challenges for prevention of human to human transmission,Eur J Intern Med,,,,2016,2010-present,May 18, 2016,27179414,10.1016/j.ejim.2016.04.022,2385,English,http://www.ncbi.nlm.nih.gov/pubmed/27179414,"'Lazzaro Spallanzani' National Institute for Infectious Diseases-IRCCS, Rome, Italy. Electronic address: giuseppina.liuzzi@inmi.it.; 'Lazzaro Spallanzani' National Institute for Infectious Diseases-IRCCS, Rome, Italy. Electronic address: emanuele.nicastri@inmi.it.; 'Lazzaro Spallanzani' National Institute for Infectious Diseases-IRCCS, Rome, Italy. Electronic address: Vincenzo.Puro@inmi.it.; Division of Infection and Immunity, University College London, London, UK; UK National Institute for Health Research Biomedical Research Centre, UCL Hospitals National Health Service Foundation Trust, London, UK. Electronic address: a.zumla@ucl.ac.uk.; 'Lazzaro Spallanzani' National Institute for Infectious Diseases-IRCCS, Rome, Italy. Electronic address: giuseppe.ippolito@inmi.it.",,,,,Saliva; Sexual transmission; Zika virus,,Pubmed,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,990,,
991,"Gao, Zhonghua Liu Xing Bing Xue Za Zhi, 2016",Gao,"Gao, Q.; Xiong, C. L.; Zhou, Y. B.; Cao, H.; Jiang, Q. W.",[Infestation status Aedes albopictus and related mosquito-borne infectious disease risk in central urban area in Shanghai],Zhonghua Liu Xing Bing Xue Za Zhi,37,5,600-5,2016,2010-present,May 18, 2016,27188346,10.3760/cma.j.issn.0254-6450.2016.05.003,2386,Other,http://www.ncbi.nlm.nih.gov/pubmed/27188346,"Department of Epidemiology, School of Public Health, Fudan University, Shanghai 200032, China; Department of Vector Control, Huangpu District Center for Disease Control and Prevention, Shanghai 200023, China.; Department of Public Health Microbiology, School of Public Health, Fudan University, Shanghai 200032, China.; Department of Vector Control, Shanghai Municipal Center for Disease Control and Prevention, Shanghai 200336, China.; Department of Vector Control, Huangpu District Center for Disease Control and Prevention, Shanghai 200023, China.; Department of Epidemiology, School of Public Health, Fudan University, Shanghai 200032, China.",,,,,,"OBJECTIVE: To evaluate Aedes albopictus infestation status in the central urban area of Shanghai, and analyze the related epidemic risk of mosquito-borne infectious disease. METHODS: Consecutive mosquito surveillance was conducted in the green lands and residential areas in the central urban area of Shanghai during 2012-2014, the Aedes albopictus density and its seasonal fluctuation were observed; the sequence of Aedes albopictus in Shanghai was aligned with that in other epidemic area abroad, and the susceptibility of Aedes albopictus to mosquito-borne virus and endemic risk were analyzed. RESULTS: No Aedes aegypti was found in the central urban area of Shanghai. As predominant species in both the residential area and the green lands, the proportion of Aedes albopictus in the residential area was significantly higher than that in the green lands(78.53% vs. 19.99%, chi(2) =15 525.168, P<0.001), and so was the density(11.91, 42.02 pcs/day . site in the residential area vs. 3.65, 2.18, 2.73 pcs/day . site in the green lands, all P value <0.001). In 2014, the density reached 42.02 pcs/day . site and the proportion reached 94.69% in the residential areas. Phylogenetic tree analysis showed that the genetic distance between Aedes albopictus in Shanghai and Aedes albopictus in Africa was quite far. CONCLUSION: No Aedes aegypti was found in Shanghai and its surrounding areas, while Aedes albopictus infestation in the central urban area of Shanghai was serious. Strict measures should be taken to reduce the Aedes albopictus density for the effective control Zika virus spread.",Pubmed,May 30, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Original research,No,Yes,991,Environmental and vector research,Ecological/animal cross-sectional
992,"Liao, Zhonghua Liu Xing Bing Xue Za Zhi, 2016",Liao,"Liao, Y.; Zeng, Z. L.; Hu, G. L.; Yang, J. P.; Yuan, H.; Li, J. H.; Zhang, X. M.; Huang, R. F.; Liu, X. Q.",[Survey of the first case of Zika virus disease in the mainland of China],Zhonghua Liu Xing Bing Xue Za Zhi,37,5,593-6,2016,2010-present,May 18, 2016,27188344,10.3760/cma.j.issn.0254-6450.2016.05.001,2465,Other,http://www.ncbi.nlm.nih.gov/pubmed/27188344,"Ganzhou Prefecture Center for Disease Control and Prevention, Ganzhou 341000, China.; Epidemiology Teaching and Research Section, Public Health School of Nanchang University, Nanchang 330026, China.; Jiangxi Provincial Center for Disease Control and Prevention, Nanchang 330029, China.; Ganxian County Center for Disease Control and Prevention, Ganxian 341100, China.",,,,,,"OBJECTIVE: To analyze epidemiological characteristics of the first laboratory confirmed case of Zika virus disease in the mainland China, and provide evidence for the prevention and control of the spread of Zika virus disease. METHODS: Epidemiological survey was conducted for the first suspect case of Zika virus disease in China, and medical observation was conducted for the close contacts. The nucleic acid detection of Zika virus was conducted with Real-time RT-PCR by using blood and urine samples collected from the cases. RESULTS: The first case of Zika virus disease was confirmed. The case was cured and discharged on 18(th) day after the onset. The blood sample on 10(th) day after the onset and urine samples on 11-13(th) days after the onset were all positive for Zika virus. The case had the history of mosquito bites in the endemic country before the onset. The close contacts showed no Zika virus disease-like symptoms during the medical observation period. CONCLUSION: The case reported by Jiangxi province was the first imported case of Zika virus disease in the mainland of China. The infection was related with the mosquito bites in Venezuela where Zika virus disease in endemic.",Pubmed,May 30, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Original research,No,Yes,992,Clinical/epidemiological research,Case report
993,"Dong, Zhonghua Liu Xing Bing Xue Za Zhi, 2016",Dong,"Dong, X. J.; Sun, J. M.; Lou, L. Q.; Zhu, Z. H.; Zhu, L. B.; Lou, T.",[Survey of the third Zika virus disease case in the mainland of China],Zhonghua Liu Xing Bing Xue Za Zhi,37,5,597-9,2016,2010-present,May 18, 2016,27188345,10.3760/cma.j.issn.0254-6450.2016.05.002,2400,Other,http://www.ncbi.nlm.nih.gov/pubmed/27188345,"Yiwu Prefecture Center for Disease Control and Prevention, Yiwu 322000, China.; Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051, China.; Yiwu Central Hospital, Yiwu 322000, China.",,,,,,"OBJECTIVE: To evaluate the performance of Zika virus(ZIKV)disease prevention and control. METHODS: Descriptive epidemiological analysis was conducted on the clinical manifestations, laboratory detection results and disease progression of the third imported ZIKV disease case in the mainland of China. RESULTS: On 19 February 2016, a ZIKV disease case was confirmed in Yiwu, Zhejiang province, which was the third imported case of ZIKV disease confirmed by China CDC laboratory and expert consulting. The patient just had a travel to Fiji and Samoa and had mosquito bite history in Samoa. The patient was hospitalized on 16 February after the onset on 14 February and the eruption on 15 February. The body temperature of the patient became normal on 17 February, the rash disappeared on 19 February and the conjunctivitis resolved on 20 February. The positive detection of the viral nucleic acid in blood was only for 3 consecutive days, and the viral nucleic acid could be detected in urine even after negative detection in blood for 4 days. CONCLUSION: The symptoms of the patient were typical. ZIKV can be detected by using blood sample in early phase, but after body temperature become normal, the virus can be detected in urine.",Pubmed,May 30, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Original research,No,Yes,993,Clinical/epidemiological research,Case report
994,"PAHO, Epidemiological update. Zika virus infection - 28 April 2016, 2016",PAHO,PAHO,Epidemiological update. Zika virus infection - 28 April 2016,,Epidemiological update. Zika virus infection - 28 April 2016,,,2016,2010-present,May 19, 2016,,,2706,,http://www.paho.org/hq/index.php?option=com_docman&task=doc_view&Itemid=270&gid=34701&lang=en,,United States,Americas,,Public/Government,,,PAHO,May 30, 2016,Yes,,Yes,,Surveillance report or data,,,No,Yes,994,Clinical/epidemiological research,Ecological study/outbreak report
995,"InVS, Point Epidemiologique CIRE Antilles Guyane, 2016",InVS,InVS,Point epidemio: Emergence du virus zika aux Antilles Guyane : Situation epidemiologique - 19 mai 2016,Point Epidemiologique CIRE Antilles Guyane,19,,,2016,2010-present,May 19, 2016,,,2248,French,http://www.invs.sante.fr/fr/Publications-et-outils/Points-epidemiologiques/Tous-les-numeros/Antilles-Guyane/2016/Situation-epidemiologique-du-virus-Zika-aux-Antilles-Guyane.-Point-au-19-mai-2016,,France,Europe,,Public/Government,,,Institute de veille sanitaire,May 30, 2016,Yes,,No,"Zika, indirect evidence or other topic",Surveillance report or data,,,No,Yes,995,Clinical/epidemiological research,Ecological study/outbreak report
996,"Camargo, Cad Saude Publica, 2016",Camargo,"Camargo, T. M.",The debate on abortion and Zika: lessons from the AIDS epidemic,Cad Saude Publica,32,5,e00071516,2016,2010-present,May 19, 2016,27192026,10.1590/0102-311X00071516,2334,English,http://www.ncbi.nlm.nih.gov/pubmed/27192026,"Letras e Ciencias Humanas, Faculdade de Filosofia, Universidade de Sao Paulo, Sao Paulo, Brazil.",,,,,,,Pubmed,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,996,,
997,"Kilianski, Emerg Infect Dis, 2016",Kilianski,"Kilianski, A.; Roth, P. A.; Liem, A. T.; Hill, J. M.; Willis, K. L.; Rossmaier, R. D.; Maranich, A. V.; Maughan, M. N.; Karavis, M. A.; Kuhn, J. H.; Honko, A. N.; Rosenzweig, C. N.",Use of Unamplified RNA/cDNA-Hybrid Nanopore Sequencing for Rapid Detection and Characterization of RNA Viruses,Emerg Infect Dis,22,8,,2016,2010-present,May 19, 2016,27191483,10.3201/eid2208.160270,2380,English,http://www.ncbi.nlm.nih.gov/pubmed/27191483,,,,,,Ebola virus; RNA virus; Venezuelan equine encephalitis virus; Zika virus; fieldable platform; genomics; nanopore sequencing; sequencing; viruses,"Nanopore sequencing, a novel genomics technology, has potential applications for routine biosurveillance, clinical diagnosis, and outbreak investigation of virus infections. Using rapid sequencing of unamplified RNA/cDNA hybrids, we identified Venezuelan equine encephalitis virus and Ebola virus in 3 hours from sample receipt to data acquisition, demonstrating a fieldable technique for RNA virus characterization.",Pubmed,May 30, 2016,Yes,,No,Unrelated to Zika virus,Scientific (journal) article,Yes,Original research,No,Yes,997,Clinical/epidemiological research,Diagnostic study
998,"Carvalho, Cad Saude Publica, 2016",Carvalho,"Carvalho, M. S.",Zika in Cadernos de Saude Publica / Reports in Public Health: again?,Cad Saude Publica,32,5,eED010516,2016,2010-present,May 19, 2016,27192031,10.1590/0102-311XED010516,2271,English,http://www.ncbi.nlm.nih.gov/pubmed/27192031,,,,,,,,Pubmed,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,998,,
999,"WHO, , 2016",WHO,WHO,"Zika situation report. Zika virus, Microcephaly and Guillain-Barré syndrome - 19 May 2016",,,,,2016,2010-present,May 19, 2016,,,2722,,http://www.who.int/emergencies/zika-virus/situation-report/en/,,Switzerland,Europe,,Public/Government,,,WHO,May 30, 2016,Yes,,No,"Zika, indirect evidence or other topic",Surveillance report or data,,,No,Yes,999,Clinical/epidemiological research,Ecological study/outbreak report
1000,"Diniz, Cad Saude Publica, 2016",Diniz,"Diniz, D.",Zika virus and women,Cad Saude Publica,32,5,e00046316,2016,2010-present,May 19, 2016,27192024,10.1590/0102-311X00046316,2357,English,http://www.ncbi.nlm.nih.gov/pubmed/27192024,"Faculdade de Direito, Universidade de Brasilia, Brasilia, Brazil.",,,,,,,Pubmed,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,1000,,
1001,"Culjat, Clin Infect Dis, 2016",Culjat,"Culjat, M.; Darling, S. E.; Nerurkar, V. R.; Ching, N.; Kumar, M.; Min, S. K.; Wong, R.; Grant, L.; Melish, M. E.",Clinical and Imaging Findings in an Infant With Zika Embryopathy,Clin Infect Dis,,,,2016,2010-present,May 20, 2016,27193747,10.1093/cid/ciw324,2288,English,http://www.ncbi.nlm.nih.gov/pubmed/27193747,"Department of Pediatrics, John A. Burns School of Medicine, University of Hawai'i at Manoa.; Department of Radiology, Kapi'olani Medical Center for Women and Children, John A. Burns School of Medicine, University of Hawai'i at Manoa.; Department of Tropical Medicine, Medical Microbiology and Pharmacology, Pacific Center for Emerging Infectious Diseases Research, John A. Burns School of Medicine, University of Hawai'i at Manoa.; Kapi'olani Medical Center for Women and Children.; Kapi'olani Medical Center for Women and Children Department of Pediatrics, Department of Tropical Medicine, Medical Microbiology and Pharmacology, Pacific Center for Emerging Infectious Diseases Research, John A. Burns School of Medicine, Honolulu, Hawaii.",United States,Americas,United States,Public/Government,Mri; Zika virus; fetal brain disruption sequence; microcephaly; ultrasound,"Recent Zika virus (ZIKV) outbreaks have been associated with an increased incidence of neonatal microcephaly. Subsequently, tropism for the brain was established in human fetal brain tissue. We present the first congenital ZIKV infection in the United States, confirmed by high ZIKV immunoglobulin M antibody titers in serum and cerebrospinal fluid. The phenotypic characteristics of the patient fall within fetal brain disruption sequence, suggesting impaired brain development in the second half of gestation. Brain imaging revealed an almost agyric brain with diffuse parenchymal calcifications, hydrocephalus ex vacuo, and cerebellar hypoplasia. Ophthalmologic examination revealed macular pigment stippling and optic nerve atrophy. Liver, lungs, heart, and bone marrow were not affected. The patient had progressive neurologic deterioration in the first month of life. The discovery of ZIKV infection in human fetal brain tissue along with serologic confirmation proves the vertical transmission of ZIKV. Therefore, ZIKV has joined the group of congenital infections.",Pubmed,May 30, 2016,Yes,,Yes,,Scientific (journal) article,Yes,Original research,No,Yes,1001,Clinical/epidemiological research,Case report
1002,", Nature, 2016",,,Diagnostics: Fast Zika test developed,Nature,533,7603,294-294,2016,2010-present,May 20, 2016,27196339,10.1038/533294b,2355,English,http://www.nature.com/nature/journal/v533/n7603/pdf/533294b.pdf,,,,,,,,Pubmed,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,News item or lay press,,,No,Yes,1002,,
1003,"Massad, Glob Health Action, 2016",Massad,"Massad, E.; Tan, S. H.; Khan, K.; Wilder-Smith, A.",Estimated Zika virus importations to Europe by travellers from Brazil,Glob Health Action,9,,31669,2016,2010-present,May 20, 2016,27193266,10.3402/gha.v9.31669,2393,English,http://www.ncbi.nlm.nih.gov/pubmed/27193266,"Department of Medicine, University of Sao Paolo, Sao Paolo, Brazil.; London School of Hygiene and Tropical Medicine, London, UK.; School of Computer Engineering, Nanyang Technological University, Singapore.; Li Ka Shing Knowledge Institute, St Michael's Hospital, Toronto, Canada.; Institute of Public Health, University of Heidelberg, Germany.; Department Public Health and Clinical Medicine, Epidemiology and Global Health, Umea University, SE-901 85 Umea, Sweden.; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore; anneliesws@gmail.com.",,,,,Brazil; Europe; Zika virus; importations; travel,"BACKGROUND: Given the interconnectivity of Brazil with the rest of the world, Zika virus (ZIKV) infections have the potential to spread rapidly around the world via viremic travellers. The extent of spread depends on the travel volume and the endemicity in the exporting country. In the absence of reliable surveillance data, we did mathematical modelling to estimate the number of importations of ZIKV from Brazil into Europe. DESIGN: We applied a previously developed mathematical model on importations of dengue to estimate the number of ZIKV importations into Europe, based on the travel volume, the probability of being infected at the time of travel, the population size of Brazil, and the estimated incidence of ZIKV infections. RESULTS: Our model estimated between 508 and 1,778 imported infections into Europe in 2016, of which we would expect between 116 and 355 symptomatic Zika infections; with the highest number of importations being into France, Portugal and Italy. CONCLUSIONS: Our model identified high-risk countries in Europe. Such data can assist policymakers and public health professionals in estimating the extent of importations in order to prepare for the scale up of laboratory diagnostic assays and estimate the occurrence of Guillain-Barre Syndrome, potential sexual transmission, and infants with congenital ZIKV syndrome.",Pubmed,May 30, 2016,Yes,,No,"Zika, not relevant to causality framework",Scientific (journal) article,Yes,Original research,No,Yes,1003,Clinical/epidemiological research,Modelling study
1004,"Whalley, Nat Rev Neurosci, 2016",Whalley,"Whalley, K.",Techniques: Spinning organoids shed light on Zika,Nat Rev Neurosci,17,6,334-5,2016,2010-present,May 20, 2016,27194600,10.1038/nrn.2016.66,2568,English,http://www.ncbi.nlm.nih.gov/pubmed/27194600,,,,,,,,Pubmed,May 30, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,1004,,
1005,", Nature, 2016",,,Virology: Zika shrinks 'mini brains' in culture,Nature,533,7602,148-148,2016,2010-present,May 20, 2016,27196274,10.1038/533148b,2309,English,http://www.nature.com/nature/journal/v533/n7602/pdf/533148b.pdf,,,,,,,,Pubmed,May 30, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",News item or lay press,,,No,Yes,1005,,
1006,"Turrini, New Microbiol, 2016",Turrini,"Turrini, F.; Ghezzi, S.; Pagani, I.; Poli, G.; Vicenzi, E.",Zika Virus: a re-emerging pathogen with rapidly evolving public health implications,New Microbiol,39,2,86-90,2016,2010-present,May 20, 2016,27196545,,2479,English,http://www.ncbi.nlm.nih.gov/pubmed/27196545,"Viral Pathogens and Biosafety Unit.; AIDS Immunopathogenesis Unit Division of Immunology, Transplantation and Infectious Diseases, Ospedale San Raffaele, Milan, Italy.; Vita-Salute San Raffaele University, School of Medicine, Milano, Italy.",,,,,Zika Virus; epidemiology; pathology; virus genome and replication,,Pubmed,May 30, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Yes,Review,No,Yes,1006,Clinical/epidemiological research,Epidemiological/clinical review
1007,", Nature, 2016",,,Zika must remain a high priority,Nature,533,7603,291,2016,2010-present,May 20, 2016,27193639,10.1038/533291a,2275,English,http://www.ncbi.nlm.nih.gov/pubmed/27193639,,,,,,Biomedical Research/*trends; Brain/pathology/virology; Brazil/epidemiology; Humans; Microcephaly/complications; Neural Stem Cells/pathology/virology; Organoids/pathology/virology; Sports; World Health Organization; Zika Virus/*pathogenicity; Zika Virus Infection/*complications/epidemiology,,Pubmed,May 30, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,1007,,
1008,"Del Carpio-Orantes, Rev Med Inst Mex Seguro Soc, 2016",Del Carpio-Orantes,"Del Carpio-Orantes, L.","[Zika, a neurotropic virus?]",Rev Med Inst Mex Seguro Soc,54,4,540-3,2016,2010-present,May 20, 2016,27197113,,2268,Spanish,http://www.ncbi.nlm.nih.gov/pubmed/27197113,"Departamento de Medicina Interna, Hospital General de Zona 71, Instituto Mexicano del Seguro Social, Veracruz, Veracruz, Mexico. neurona23@hotmail.com.",,,,,Arbovirus infections; Arboviruses; Epidemiological surveillance; Epidemiology,"In this paper, the neurotropism potential Zika virus is discussed, by comparison with viruses both RNA and DNA are neurotropic known, also it is said that compared with the new viruses that have affected the Americas, as the chikungunya, Zika has shown great affinity by brain tissue, manifested by a high incidence of acute neurological conditions, such as Guillain-Barre syndrome, among others, as well as the reported incidence of microcephaly that is abnormally high compared with the previous incidence, which, in a stillborn subject necropsied significant alterations demonstrated in brain tissue, identifying viral material and live virus in the fetoplacental complex, and demonstrating the impact both white matter and gray matter as well as basal ganglia, corpus callosum, ventricles and spinal cord, which could explain the microcephaly that concerns him. Although not a direct cause-effect relationship is demonstrated, however current evidence supports that relationship, hoping to be supported scientifically.; Publisher: Abstract available from the publisher.; spa",Pubmed,May 30, 2016,No,No full-text obtained yet,,,Scientific (journal) article,Unknown/unclear,Review,No,Yes,1008,Clinical/epidemiological research,Epidemiological/clinical review
1009,"Alfaro-Murillo, PLoS Negl Trop Dis, 2016",Alfaro-Murillo,"Alfaro-Murillo, J. A.; Parpia, A. S.; Fitzpatrick, M. C.; Tamagnan, J. A.; Medlock, J.; Ndeffo-Mbah, M. L.; Fish, D.; Avila-Aguero, M. L.; Marin, R.; Ko, A. I.; Galvani, A. P.",A Cost-Effectiveness Tool for Informing Policies on Zika Virus Control,PLoS Negl Trop Dis,10,5,e0004743,2016,2010-present,May 21, 2016,27205899,10.1371/journal.pntd.0004743,2300,English,http://www.ncbi.nlm.nih.gov/pubmed/27205899,"Center for Infectious Disease Modeling and Analysis, Yale School of Public Health, Yale University, New Haven, Connecticut, United States of America.; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, Yale University, New Haven, Connecticut, United States of America.; Department of Biomedical Sciences, College of Veterinary Medicine, Oregon State University, Corvallis, Oregon, United States of America.; Pediatric Infectious Diseases Department, Hospital Nacional de Ninos 'Dr. Carlos Saenz Herrera', San Jose, Costa Rica.; Programa de Control de Vectores, Ministerio de Salud, San Jose, Costa Rica.; Centro de Pesquisas Goncalo Moniz, Fundacao Oswaldo Cruz, Ministerio da Saude, Salvador, Bahia, Brasil.; Department of Ecology and Evolutionary Biology, Yale University, New Haven, Connecticut, United States of America.",,,,,,"BACKGROUND: As Zika virus continues to spread, decisions regarding resource allocations to control the outbreak underscore the need for a tool to weigh policies according to their cost and the health burden they could avert. For example, to combat the current Zika outbreak the US President requested the allocation of $1.8 billion from Congress in February 2016. METHODOLOGY/PRINCIPAL FINDINGS: Illustrated through an interactive tool, we evaluated how the number of Zika cases averted, the period during pregnancy in which Zika infection poses a risk of microcephaly, and probabilities of microcephaly and Guillain-Barre Syndrome (GBS) impact the cost at which an intervention is cost-effective. From Northeast Brazilian microcephaly incidence data, we estimated the probability of microcephaly in infants born to Zika-infected women (0.49% to 2.10%). We also estimated the probability of GBS arising from Zika infections in Brazil (0.02% to 0.06%) and Colombia (0.08%). We calculated that each microcephaly and GBS case incurs the loss of 29.95 DALYs and 1.25 DALYs per case, as well as direct medical costs for Latin America and the Caribbean of $91,102 and $28,818, respectively. We demonstrated the utility of our cost-effectiveness tool with examples evaluating funding commitments by Costa Rica and Brazil, the US presidential proposal, and the novel approach of genetically modified mosquitoes. Our analyses indicate that the commitments and the proposal are likely to be cost-effective, whereas the cost-effectiveness of genetically modified mosquitoes depends on the country of implementation. CONCLUSIONS/SIGNIFICANCE: Current estimates from our tool suggest that the health burden from microcephaly and GBS warrants substantial expenditures focused on Zika virus control. Our results justify the funding committed in Costa Rica and Brazil and many aspects of the budget outlined in the US president's proposal. As data continue to be collected, new parameter estimates can be customized in real-time within our user-friendly tool to provide updated estimates on cost-effectiveness of interventions and inform policy decisions in country-specific settings.",Pubmed,May 30, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Original research,No,Yes,1009,Clinical/epidemiological research,Modelling study
1010,"Bouyer, Lancet Glob Health, 2016",Bouyer,"Bouyer, J.; Chandre, F.; Gilles, J.; Baldet, T.","Alternative vector control methods to manage the Zika virus outbreak: more haste, less speed",Lancet Glob Health,4,6,e364,2016,2010-present,May 21, 2016,27198837,10.1016/S2214-109X(16)00082-6,2282,English,http://www.ncbi.nlm.nih.gov/pubmed/27198837,"Unite Mixte de Recherche Controle des Maladies Animales Exotiques et Emergentes, Centre de Cooperation Internationale en Recherche Agronomique pour le Developpement (CIRAD), 34398 Montpellier, France. Electronic address: bouyer@cirad.fr.; Unite Mixte de Recherche Maladies infectieuses et vecteurs: ecologie, genetique, evolution et controle, Institut de Recherche pour le Developpement, Montpellier, France.; Insect Pest Control Laboratory, Joint FAO/IAEA Division of Nuclear Techniques in Food and Agriculture, Vienna, Austria.; Unite Mixte de Recherche Controle des Maladies Animales Exotiques et Emergentes, Centre de Cooperation Internationale en Recherche Agronomique pour le Developpement (CIRAD), 34398 Montpellier, France.",,,,,,,Pubmed,May 30, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,1010,,
1011,"Boete, Lancet Glob Health, 2016",Boete,"Boete, C.; Reeves, R. G.","Alternative vector control methods to manage the Zika virus outbreak: more haste, less speed",Lancet Glob Health,4,6,e363,2016,2010-present,May 21, 2016,27198836,10.1016/S2214-109X(16)00084-X,2337,English,http://www.ncbi.nlm.nih.gov/pubmed/27198836,"UMR 'Emergence des Pathologies Virales', Aix-Marseille Universite, IRD 190-Inserm 1207-EHESP, 13385 Marseille, France. Electronic address: cboete@gmail.com.; Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Biology, Plon, Germany.",,,,,,,Pubmed,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,1011,,
1012,"Yakob, Lancet Glob Health, 2016",Yakob,"Yakob, L.; Walker, T.","Alternative vector control methods to manage the Zika virus outbreak: more haste, less speed - Authors' reply",Lancet Glob Health,4,6,e365-6,2016,2010-present,May 21, 2016,27198838,10.1016/S2214-109X(16)00086-3,2633,English,http://www.ncbi.nlm.nih.gov/pubmed/27198838,"Department of Disease Control, London School of Hygiene & Tropical Medicine, London WC1E 7HT, UK. Electronic address: laith.yakob@lshtm.ac.uk.; Department of Disease Control, London School of Hygiene & Tropical Medicine, London WC1E 7HT, UK.",,,,,,,Pubmed,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,1012,,
1013,"Shan, Cell Host Microbe, 2016",Shan,"Shan, C.; Xie, X.; Muruato, A. E.; Rossi, S. L.; Roundy, C. M.; Azar, S. R.; Yang, Y.; Tesh, R. B.; Bourne, N.; Barrett, A. D.; Vasilakis, N.; Weaver, S. C.; Shi, P. Y.","An Infectious cDNA Clone of Zika Virus to Study Viral Virulence, Mosquito Transmission, and Antiviral Inhibitors",Cell Host Microbe,19,6,891-900,2016,2010-present,May 21, 2016,27198478,10.1016/j.chom.2016.05.004,2530,English,http://www.ncbi.nlm.nih.gov/pubmed/27198478,"Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555, USA.; Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, TX 77555, USA; Institute for Translational Science, University of Texas Medical Branch, Galveston, TX 77555, USA.; Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, TX 77555, USA; Department of Pathology and Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, TX 77555, USA.; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA; Sealy Center for Vaccine Development, University of Texas Medical Branch, Galveston, TX 77555, USA; Department of Pediatrics, University of Texas Medical Branch, Galveston, TX 77555, USA.; Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, TX 77555, USA; Department of Pathology and Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, TX 77555, USA; Sealy Center for Vaccine Development, University of Texas Medical Branch, Galveston, TX 77555, USA.; Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, TX 77555, USA; Institute for Translational Science, University of Texas Medical Branch, Galveston, TX 77555, USA; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA; Sealy Center for Vaccine Development, University of Texas Medical Branch, Galveston, TX 77555, USA; Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX 77555, USA.; Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555, USA; Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX 77555, USA; Sealy Center for Structural Biology and Molecular Biophysics, University of Texas Medical Branch, Galveston, TX 77555, USA. Electronic address: peshi@utmb.edu.",,,,,Zika virus; antiviral drug discovery; flavivirus; genetic system; mosquito transmission; viral virulence,"The Asian lineage of Zika virus (ZIKV) has recently caused epidemics and severe disease. Unraveling the mechanisms causing increased viral transmissibility and disease severity requires experimental systems. We report an infectious cDNA clone of ZIKV that was generated using a clinical isolate of the Asian lineage. The cDNA clone-derived RNA is infectious in cells, generating recombinant ZIKV. The recombinant virus is virulent in established ZIKV mouse models, leading to neurological signs relevant to human disease. Additionally, recombinant ZIKV is infectious for Aedes aegypti and thus provides a means to examine virus transmission. The infectious cDNA clone was further used to generate a luciferase ZIKV that exhibited sensitivity to a panflavivirus inhibitor, highlighting its potential utility for antiviral screening. This ZIKV reverse genetic system, together with mouse and mosquito infection models, may help identify viral determinants of human virulence and mosquito transmission as well as inform vaccine and therapeutic strategies.",Pubmed,May 30, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Original research,No,Yes,1013,Basic and applied biomedical research,Other basic research
1014,"Kvajo, Cell, 2016",Kvajo,"Kvajo, M.; Monteiro, J.",Publishing Science in the Time of Zika,Cell,165,5,1029,2016,2010-present,May 21, 2016,27203101,10.1016/j.cell.2016.05.030,2377,English,http://www.ncbi.nlm.nih.gov/pubmed/27203101,,,,,,,,Pubmed,May 30, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,1014,,
1015,"Johnson, State Legis, 2016",Johnson,"Johnson, T.",Taking the Bite out of Zika,State Legis,42,5,22. Mai,2016,2010-present,May 21, 2016,27197311,,2256,English,http://www.ncbi.nlm.nih.gov/pubmed/27197311,"National Conference of State Legislatures, USA",,,,,"Aedes/*virology; Animals; Federal Government; Financing, Government; Humans; Insect Vectors/virology; Local Government; Mosquito Control/economics/*legislation & jurisprudence; State Government; United States; Zika Virus; Zika Virus Infection/epidemiology/*prevention & control/transmission",,Pubmed,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,News item or lay press,,,No,Yes,1015,,
1016,"Silveira, J Heart Lung Transplant, 2016",Silveira,"Silveira, F. P.; Campos, S. V.",The Zika epidemics and transplantation,J Heart Lung Transplant,35,5,560-3,2016,2010-present,May 21, 2016,27197772,10.1016/j.healun.2016.03.010,2536,English,http://www.ncbi.nlm.nih.gov/pubmed/27197772,"Division of Infectious Diseases, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania. Electronic address: silveirafd@upmc.edu.; Pulmonary Division, Lung Transplant Group, Heart Institute (InCor), University of Sao Paulo, Sao Paulo, Brazil.",,,,,Guillain-Barre syndrome; Zika virus; complications; donor-derived infection; microcephaly; transplantation,"In the last few months an epidemic of Zika virus (ZIKV) has affected several countries, and it continues to spread rapidly. This virus was initially thought to cause only a mild febrile illness; however, the current epidemic has shown that it is associated with serious complications. Increasing reports are linking ZIKV to devastating conditions such as microcephaly in newborns and important neurologic syndromes. Although ZIKV infection has not yet been reported in transplant recipients, it is likely that it will be reported soon because of the number of transplants performed in affected areas and global travel. We discuss the effect of ZIKV in transplantation and propose recommendations to prevent donor-derived infections.",Pubmed,May 30, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,1016,,
1017,"Jaffe, Lancet, 2016",Jaffe,"Jaffe, S.",US responds to increase in Zika cases,Lancet,387,10030,1801-2,2016,2010-present,May 21, 2016,27203490,10.1016/S0140-6736(16)30360-9,2409,English,http://www.ncbi.nlm.nih.gov/pubmed/27203490,,,,,,Aedes; Animals; Humans; United States/epidemiology; *Zika Virus; *Zika Virus Infection/epidemiology/prevention & control,,Pubmed,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,News item or lay press,,,No,Yes,1017,,
1018,"Musso, Lancet, 2016",Musso,"Musso, D.; de Pina, J. J.; Nhan, T. X.; Deparis, X.",Uncommon presentation of Zika fever or co-infection?,Lancet,387,10030,1812-3,2016,2010-present,May 21, 2016,27203498,10.1016/S0140-6736(16)30317-8,2510,English,http://www.ncbi.nlm.nih.gov/pubmed/27203498,"Unit of Emerging Infectious Diseases, Institut Louis Malarde, Tahiti 98713, French Polynesia. Electronic address: dmusso@ilm.pf.; Diagnosis Laboratory, Institut Louis Malarde, Tahiti 98713, French Polynesia.; French Center of Epidemiology and Public Health, UMR SESSTIM, Marseille, France.",,,,,Female; Hematoma/*virology; Humans; Thrombocytopenia/*virology; Zika Virus Infection/*complications/*diagnosis,,Pubmed,May 30, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,1018,,
1019,"Grobusch, Lancet, 2016",Grobusch,"Grobusch, M. P.; Karimi, O.; Schinkel, J.; Codrington, J.; Vreden, S. G.; Vermaat, J. S.; Stijnis, C.; Goorhuis, A.",Uncommon presentation of Zika fever or co-infection? - Authors' reply,Lancet,387,10030,1813-4,2016,2010-present,May 21, 2016,27203499,10.1016/S0140-6736(16)30178-7,2378,English,http://www.ncbi.nlm.nih.gov/pubmed/27203499,"Center of Tropical Medicine and Travel Medicine, Department of Infectious Diseases, Division of Internal Medicine, Academic Medical Center, University of Amsterdam, 1100 DD Amsterdam, Netherlands. Electronic address: m.p.grobusch@amc.uva.nl.; Center of Tropical Medicine and Travel Medicine, Department of Infectious Diseases, Division of Internal Medicine, Academic Medical Center, University of Amsterdam, 1100 DD Amsterdam, Netherlands.; Laboratory of Clinical Virology, Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, 1100 DD Amsterdam, Netherlands.; Department of Laboratory, Academic Hospital Paramaribo, Paramaribo, Suriname.; Internal Medicine and Infectious Diseases, Academic Hospital Paramaribo, Paramaribo, Suriname.; Department of Hematology, Division of Internal Medicine, Academic Medical Center, University of Amsterdam, 1100 DD Amsterdam, Netherlands.",,,,,Female; Hematoma/*virology; Humans; Thrombocytopenia/*virology; Zika Virus Infection/*complications/*diagnosis,,Pubmed,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,1019,,
1020,"Coombes, BMJ, 2016",Coombes,"Coombes, R.; head of, features; investigations,",Call to cancel 2016 Olympics because of Zika risk is not backed by WHO guidance,BMJ,353,,i2899,2016,2010-present,May 22, 2016,27207862,10.1136/bmj.i2899,2306,English,http://www.ncbi.nlm.nih.gov/pubmed/27207862,The BMJ.,,,,,,,Pubmed,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,1020,,
1021,"Rodriguez-Morales, Int J Infect Dis, 2016",Rodriguez-Morales,"Rodriguez-Morales, A. J.; Patino-Cadavid, L. J.; Lozada-Riascos, C. O.; Villamil-Gomez, W. E.",Mapping Zika in municipalities of one coastal department of Colombia (Sucre) using geographic information systems during the 2015-2016 outbreak: implications for public health and travel advice,Int J Infect Dis,48,,70-2,2016,2010-present,May 22, 2016,27208632,10.1016/j.ijid.2016.05.012,2471,English,http://www.ncbi.nlm.nih.gov/pubmed/27208632,"Public Health and Infection Research Group, Faculty of Health Sciences, Universidad Tecnologica de Pereira, Pereira, Risaralda, Colombia; Organizacion Latinoamericana para el Fomento de la Investigacion en Salud (OLFIS), Bucaramanga, Santander, Colombia; Colombian Collaborative Network on Zika (RECOLZIKA), Pereira, Risaralda, Colombia. Electronic address: arodriguezm@utp.edu.co.; Public Health and Infection Research Group, Faculty of Health Sciences, Universidad Tecnologica de Pereira, Pereira, Risaralda, Colombia.; Colombian Collaborative Network on Zika (RECOLZIKA), Pereira, Risaralda, Colombia; Regional Information System, Universidad Tecnologica de Pereira, Pereira, Risaralda, Colombia.; Colombian Collaborative Network on Zika (RECOLZIKA), Pereira, Risaralda, Colombia; Infectious Diseases and Infection Control Research Group, Hospital Universitario de Sincelejo, Sincelejo, Sucre, Colombia; SUE Caribe Programa del Doctorado de Medicina Tropical, Universidad del Atlantico, Barranquilla, Colombia.",,,,,Colombia; Epidemiology; Latin America; Public health; Travelers; Zika,,Pubmed,May 30, 2016,Yes,,No,"Zika, not relevant to causality framework",Scientific (journal) article,Unknown/unclear,Original research,No,Yes,1021,Clinical/epidemiological research,Ecological study/outbreak report
1022,"Wiwanitkit, Am J Reprod Immunol, 2016",Wiwanitkit,"Wiwanitkit, V.","Placenta, Zika Virus Infection and Fetal Brain Abnormality",Am J Reprod Immunol,,,,2016,2010-present,May 22, 2016,27207189,10.1111/aji.12521,2662,English,http://www.ncbi.nlm.nih.gov/pubmed/27207189,"Faculty of Medicine, University of Nis, Nis, Serbia.; Hainan Medical University, Hainan, China.; Dr DY Patil Medical University, Maharashtra, India.; Joseph Ayobabalola University, Ikeki-Arakeji, Nigeria.; Surin Rajabhat University, Surin, Thailand.",,,,,,,Pubmed,May 30, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,1022,,
1023,"Qin, Sci China Life Sci, 2016",Qin,"Qin, X. F.",Understanding the pathogenic evolution of zika Virus,Sci China Life Sci,,,,2016,2010-present,May 22, 2016,27207138,10.1007/s11427-016-5069-7,2488,English,http://www.ncbi.nlm.nih.gov/pubmed/27207138,"Center of Systems Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100005, China. fqin1@foxmail.com.; Suzhou Institute of Systems Medicine, Suzhou, 215123, China. fqin1@foxmail.com.",,,,,,,Pubmed,May 30, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,1023,,
1024,"Gulland, BMJ, 2016",Gulland,"Gulland, A.",WHO warns of risk of Zika virus in Europe,BMJ,353,,i2887,2016,2010-present,May 22, 2016,27207768,10.1136/bmj.i2887,2427,English,http://www.ncbi.nlm.nih.gov/pubmed/27207768,London.,,,,,,,Pubmed,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,News item or lay press,,,No,Yes,1024,,
1025,"da Silva, J Med Virol, 2016",da Silva,"da Silva, S. R.; Gao, S. J.",Zika virus update II: Recent development of animal models - proofs of association with human pathogenesis,J Med Virol,,,,2016,2010-present,May 22, 2016,27208545,10.1002/jmv.24582,2280,English,http://www.ncbi.nlm.nih.gov/pubmed/27208545,"Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, California.",,,,,Zika virus; animal model; pathology,"Three recent studies in pregnant mice and one ongoing study in rhesus macaques evaluating the effect of ZIKV infection have provided important information about maternal-fetus transmission and ZIKV-related pathogenesis, confirming a causal role of ZIKV in neurological problems observed in humans. Here, we present an update of these works published in the past few weeks. This article is protected by copyright. All rights reserved.",Pubmed,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,1025,,
1026,"Vorou, Int J Infect Dis, 2016",Vorou,"Vorou, R.","Zika virus, vectors, reservoirs, amplifying hosts, and their potential to spread worldwide: what we know and what we should investigate urgently",Int J Infect Dis,48,,85-90,2016,2010-present,May 22, 2016,27208633,10.1016/j.ijid.2016.05.014,2506,English,http://www.ncbi.nlm.nih.gov/pubmed/27208633,"Hellenic Center for Disease Control and Prevention, 3-5 Agrafon str., Marousi, Athens, PC 15 123, Greece. Electronic address: vorou@keelpno.gr.",,,,,Aedes; Animal; Anopheles; Migrants; Vector; Zika virus infection,"OBJECTIVES: The widespread epidemic of Zika virus infection in South and Central America and the Caribbean in 2015, along with the increased incidence of microcephaly in fetuses born to mothers infected with Zika virus and the potential for worldwide spread, indicate the need to review the current literature regarding vectors, reservoirs, and amplification hosts. VECTORS: The virus has been isolated in Africa in mosquitoes of the genera Aedes, Anopheles, and Mansonia, and in Southeast Asia and the Pacific area in mosquitoes of the genus Aedes. Aedes albopictus has invaded several countries in Central Africa and all Mediterranean countries, and continues to spread throughout Central and Northern Europe. The wide distribution of the virus in animal hosts and vectors favors the emergence of recombinants. ANIMAL HOSTS: The virus has been isolated in monkeys, and antibodies have been detected in domestic sheep, goats, horses, cows, ducks, rodents, bats, orangutans, and carabaos. CONCLUSIONS: It is a public health imperative to define the domestic and wild animal reservoirs, amplification hosts, and vector capacity of the genera Aedes, Anopheles, and Mansonia. These variables will define the geographic distribution of Zika virus along with the indicated timing and scale of the environmental public health interventions worldwide.",Pubmed,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Yes,Original research,No,Yes,1026,Clinical/epidemiological research,Epidemiological/clinical review
1027,"Zhang, Protein Cell, 2016",Zhang,"Zhang, Y.; Chen, W.; Wong, G.; Bi, Y.; Yan, J.; Sun, Y.; Chen, E.; Yan, H.; Lou, X.; Mao, H.; Xia, S.; Gao, G. F.; Shi, W.; Chen, Z.","Highly diversified Zika viruses imported to China, 2016",Protein Cell,7,6,461-4,2016,2010-present,May 23, 2016,27209301,10.1007/s13238-016-0274-5,2608,English,http://www.ncbi.nlm.nih.gov/pubmed/27209301,"Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, 310051, China.; Yiwu Center for Disease Control and Prevention, Yiwu, 322000, China.; CAS Key Laboratory of Pathogenic Microbiology and Immunology (CASPMI), Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, China.; Center for Influenza Research and Early-Warning (CASCIRE), Chinese Academy of Sciences, Beijing, 100101, China.; Shenzhen Key Laboratory of Pathogen and Immunity, Shenzhen Third People's Hospital, Shenzhen, 518112, China.; Office of Director-General, Chinese Center for Disease Control and Prevention (China CDC), Beijing, 102206, China.; Institute of Pathogen Biology, Taishan Medical College, Taian, 271000, China. shiwf@ioz.ac.cn.; Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, 310051, China. zhpchen@cdc.zj.cn.",,,,,,,Pubmed,May 30, 2016,Yes,,No,"Zika, not relevant to causality framework",Scientific (journal) article,Unknown/unclear,Original research,No,Yes,1027,Basic and applied biomedical research,Sequence analysis and phylogenetics
1028,"Duijster, Infection, 2016",Duijster,"Duijster, J. W.; Goorhuis, A.; van Genderen, P. J.; Visser, L. G.; Koopmans, M. P.; Reimerink, J. H.; Grobusch, M. P.; van der Eijk, A. A.; van den Kerkhof, J. H.; Reusken, C. B.; Hahne, S. J.; Dutch, Zikv study team","Zika virus infection in 18 travellers returning from Surinam and the Dominican Republic, The Netherlands, November 2015-March 2016",Infection,,,,2016,2010-present,May 23, 2016,27209175,10.1007/s15010-016-0906-y,2431,English,http://www.ncbi.nlm.nih.gov/pubmed/27209175,"Centre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM) Bilthoven, Antonie van Leeuwenhoeklaan 9, 3721 MA, Bilthoven, The Netherlands. janneke.duijster@rivm.nl.; Division of Internal Medicine, Department of Infectious Diseases, Center of Tropical Medicine and Travel Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, A01-330, 1105 AZ, Amsterdam, The Netherlands.; Institute for Tropical Diseases, Harbour Hospital, Rotterdam, Haringvliet 72, 3011 TG, Rotterdam, The Netherlands.; Department of Infectious Diseases, Leiden University Medical Centre, Leiden, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands.; Department of Viroscience, WHO Collaborating Centre for Arbovirus and Haemorrhagic Fever Reference and Research, Erasmus MC, Rotterdam, Wytemaweg 80, Ee 1726, 3015 CN, Rotterdam, The Netherlands.; Centre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM) Bilthoven, Antonie van Leeuwenhoeklaan 9, 3721 MA, Bilthoven, The Netherlands.",Netherlands,Europe,Netherlands,Not reported/unknown,Dominican Republic; Imported viral diseases; Netherlands; Surinam; Travel; Zika virus,"PURPOSE: We report 18 cases of confirmed Zika virus (ZIKV) infection in travellers returning to the Netherlands from Surinam (South America, bordering northern Brazil) and the Dominican Republic. METHODS: In a multi-centre study, we collected epidemiological, virological and clinical characteristics, as well as data on travel history, underlying illness and laboratory results of the 18 imported ZIKV infection cases using a standardised form. RESULTS: Most cases had a self-limiting course of disease, two patients developed complications, one had Guillain-Barre and another had severe thrombocytopenia. Four patients had underlying illness. One of the reported cases was pregnant. Three of 13 patients tested had a weak-positive result for dengue IgM. The majority of patients were born in Suriname and/or visiting friends and relatives (VFR). CONCLUSIONS: Providing pre-travel advice among travellers, especially VFR travellers, is needed to enhance the use of preventive measures against ZIKV infection. Further evidence on health risks associated with ZIKV infection is urgently needed.",Pubmed,May 30, 2016,Yes,,Yes,,Scientific (journal) article,Yes,Original research,Yes,Yes,1028,Clinical/epidemiological research,Case report
1029,"Aliota, PLoS Negl Trop Dis, 2016",Aliota,"Aliota, M. T.; Caine, E. A.; Walker, E. C.; Larkin, K. E.; Camacho, E.; Osorio, J. E.",Characterization of Lethal Zika Virus Infection in AG129 Mice,PLoS Negl Trop Dis,10,4,e0004682,2016,2010-present,May 24, 2016,27093158,10.1371/journal.pntd.0004682,2284,English,http://www.ncbi.nlm.nih.gov/pubmed/27093158,,United States,Americas,United States,Public/Government,,"BACKGROUND: Mosquito-borne Zika virus (ZIKV) typically causes a mild and self-limiting illness known as Zika fever, which often is accompanied by maculopapular rash, headache, and myalgia. During the current outbreak in South America, ZIKV infection during pregnancy has been hypothesized to cause microcephaly and other diseases. The detection of ZIKV in fetal brain tissue supports this hypothesis. Because human infections with ZIKV historically have remained sporadic and, until recently, have been limited to small-scale epidemics, neither the disease caused by ZIKV nor the molecular determinants of virulence and/or pathogenicity have been well characterized. Here, we describe a small animal model for wild-type ZIKV of the Asian lineage. METHODOLOGY/PRINCIPAL FINDINGS: Using mice deficient in interferon alpha/beta and receptors (AG129 mice), we report that these animals were highly susceptible to ZIKV infection and disease, succumbing within seven to eight days. Rapid viremic dissemination was observed in visceral organs and brain; but only was associated with severe pathologies in the brain and muscle. Finally, these results were consistent across challenge routes, age of mice, and inoculum doses. These data represent a mouse model for ZIKV that is not dependent on adapting ZIKV to intracerebral passage in mice. CONCLUSIONS/SIGNIFICANCE: Foot pad injection of AG129 mice with ZIKV represents a biologically relevant model for studying ZIKV infection and disease development following wild-type virus inoculation without the requirement for adaptation of the virus or intracerebral delivery of the virus. This newly developed Zika disease model can be exploited to identify determinants of ZIKV virulence and reveal molecular mechanisms that control the virus-host interaction, providing a framework for rational design of acute phase therapeutics and for vaccine efficacy testing.",Pubmed,May 30, 2016,Yes,,Yes,,Scientific (journal) article,Yes,Original research,No,Yes,1029,Basic and applied biomedical research,Animal experiment
1030,"Tripp, Expert Rev Vaccines, 2016",Tripp,"Tripp, R. A.; Ross, T. M.",Development of a Zika vaccine,Expert Rev Vaccines,,,01. Mrz,2016,2010-present,May 24, 2016,27212079,10.1080/14760584.2016.1192474,2548,English,http://www.ncbi.nlm.nih.gov/pubmed/27212079,"a Department of Infectious Diseases, Animal Health Research Center , University of Georgia , Athens , GA , USA.; b Department of Infectious Diseases, Center for Vaccines and Immunology , University of Georgia , Athens , GA , USA.",,,,,Zika; countermeasures; immunity; vaccine; virus,,Pubmed,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,1030,,
1031,"Khakshooy, Bioinformation, 2016",Khakshooy,"Khakshooy, A.; Chiappelli, F.",Hypothalamus-Pituitary-Adrenal cell-mediated immunity regulation in the Immune Restoration Inflammatory Syndrome,Bioinformation,12,1,28-31,2016,2010-present,May 24, 2016,27212842,10.6026/97320630012028,2449,English,http://www.ncbi.nlm.nih.gov/pubmed/27212842,"Oral Biology and Medicine, Center for the health Sciences University of California Los Angeles, USA; Health Sciences, California State University, Northridge, USA.; Oral Biology and Medicine, Center for the health Sciences University of California Los Angeles, USA; Evidence-Based Decisions Practice-Based Research Network, USA.",,,,,,"Over one third of the patients sero-positive for the human immunodeficiency virus (HIV) with signs of the acquired immune deficiency syndrome (AIDS), and under treatment with anti-retroviral therapy (ART), develop the immune reconstitution inflammatory syndrome (IRIS). It is not clear what variables are that determine whether a patient with HIV/AIDS will develop ART-related IRIS, but the best evidence base thus far indicates that HIV/AIDS patients with low CD4 cell count, and HIV/AIDS patients whose CD4 count recovery shows a sharp slope, suggesting a particularly fast 'immune reconstitution', are at greater risk of developing IRIS. Here, we propose the hypothesis that one important variable that can contribute to low CD4 cell count number and function in ART-treated HIV/AIDS patients is altered hypothalamic-pituitary-adrenal (HPA) cell-mediated immune (CMI) regulation. We discuss HPA-CMI deregulation in IRIS as the new frontier in comparative effectiveness research (CRE) for obtaining and utilizing the best evidence base for treatment of patients with HIV/AIDS in specific clinical settings. We propose that our hypothesis about altered HPA-CMI may extend to the pathologies observed in related viral infection, including Zika.",Pubmed,May 30, 2016,No,Unrelated to Zika virus,,,Scientific (journal) article,Yes,Review,No,Yes,1031,Basic and applied biomedical research,Basic research review
1032,"Hofer, Nat Rev Microbiol, 2016",Hofer,"Hofer, U.",Viral Pathogenesis: Tracing the steps of Zika virus,Nat Rev Microbiol,14,7,401,2016,2010-present,May 24, 2016,27211788,10.1038/nrmicro.2016.80,2446,English,http://www.ncbi.nlm.nih.gov/pubmed/27211788,,,,,,,,Pubmed,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,1032,,
1033,"Oladapo, Lancet Glob Health, 2016",Oladapo,"Oladapo, O. T.; Souza, J. P.; De Mucio, B.; de Leon, R. G.; Perea, W.; Gulmezoglu, A. M.; W. H. O. Guideline Development Group",WHO interim guidance on pregnancy management in the context of Zika virus infection,Lancet Glob Health,,,,2016,2010-present,May 24, 2016,27211476,10.1016/S2214-109X(16)30098-5,2467,English,http://www.ncbi.nlm.nih.gov/pubmed/27211476,"UNDP/UNFPA/UNICEF/WHO/World Bank Special Programme of Research, Development and Research Training in Human Reproduction, Department of Reproductive Health and Research, World Health Organization, 1211 Geneva 27, Switzerland. Electronic address: oladapoo@who.int.; UNDP/UNFPA/UNICEF/WHO/World Bank Special Programme of Research, Development and Research Training in Human Reproduction, Department of Reproductive Health and Research, World Health Organization, 1211 Geneva 27, Switzerland.; Latin American Centre for Perinatology, Pan American Health Organization, Montevideo, Uruguay.; Department of Pandemic and Epidemic Diseases, World Health Organization, Geneva, Switzerland.",,,,,,,Pubmed,May 30, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Original research,No,Yes,1033,Clinical/epidemiological research,Guidelines
1034,"Grant, Cell Host Microbe, 2016",Grant,"Grant, A.; Ponia, S. S.; Tripathi, S.; Balasubramaniam, V.; Miorin, L.; Sourisseau, M.; Schwarz, M. C.; Sanchez-Seco, M. P.; Evans, M. J.; Best, S. M.; Garcia-Sastre, A.",Zika Virus Targets Human STAT2 to Inhibit Type I Interferon Signaling,Cell Host Microbe,19,6,882-90,2016,2010-present,May 24, 2016,27212660,10.1016/j.chom.2016.05.009,2457,English,http://www.ncbi.nlm.nih.gov/pubmed/27212660,"Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Laboratory of Virology, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, NIH, Hamilton, MT 59840, USA.; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Laboratory of Arbovirus and Imported Viral Diseases, National Center of Microbiology, Institute of Health Carlos III, 28029 Madrid, Spain.; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address: adolfo.garcia-sastre@mssm.edu.",United States,Americas,United States,Public/Government,,"The ongoing epidemic of Zika virus (ZIKV) illustrates the importance of flaviviruses as emerging human pathogens. All vector-borne flaviviruses studied thus far have to overcome type I interferon (IFN) to replicate and cause disease in vertebrates. The mechanism(s) by which ZIKV antagonizes IFN signaling is unknown. Here, we report that the nonstructural protein NS5 of ZIKV and other flaviviruses examined could suppress IFN signaling, but through different mechanisms. ZIKV NS5 expression resulted in proteasomal degradation of the IFN-regulated transcriptional activator STAT2 from humans, but not mice, which may explain the requirement for IFN deficiency to observe ZIKV-induced disease in mice. The mechanism of ZIKV NS5 resembles dengue virus (DENV) NS5 and not its closer relative, Spondweni virus (SPOV). However, unlike DENV, ZIKV did not require the E3 ubiquitin ligase UBR4 to induce STAT2 degradation. Hence, flavivirus NS5 proteins exhibit a remarkable functional convergence in IFN antagonism, albeit by virus-specific mechanisms.",Pubmed,May 30, 2016,Yes,,No,"Zika, indirect evidence or other topic",Scientific (journal) article,Yes,Original research,No,Yes,1034,Basic and applied biomedical research,In vitro experiment
1035,"Chibueze, Bull World Health Organ, 2016",Chibueze,"Chibueze, Ezinne C.; Parsons, Alex J. Q.; Lopes, Katharina da Silva; Yo, Takemoto; Swa, Toshiyuki; Nagata, Chie; Horita, Nobuyuki; Morisaki, Naho; Balogun, Olukunmi O.; Dagvadorj, Amarjargal; Ota, Erika; Mori, Rintaro; Oladapo, Olufemi T.",Accuracy of ultrasound scanning relative to reference tests for prenatal diagnosis of microcephaly in the context of Zika virus infection: a systematic review of diagnostic test accuracy,Bull World Health Organ,published online 25.05.2016 (submitted 24.05.2016),,,2016,2010-present,May 25, 2016,,10.2471/blt.16.178301,2750,,http://www.who.int/bulletin/online_first/16-178301.pdf,,,,,,,,WHO Zika open,May 30, 2016,Yes,,No,"Zika, not relevant to causality framework",Scientific (journal) article,No,Original research,No,Yes,1035,Clinical/epidemiological research,Epidemiological/clinical review
1036,"McCarthy, BMJ, 2016",McCarthy,"McCarthy, M.",Obama calls on Congress to fully fund Zika response,BMJ,353,,i2921,2016,2010-present,May 25, 2016,27216764,10.1136/bmj.i2921,2417,English,http://www.ncbi.nlm.nih.gov/pubmed/27216764,Seattle.,,,,,,,Pubmed,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,News item or lay press,,,No,Yes,1036,,
1037,"Ladner, Rev Sci Tech, 2016",Ladner,"Ladner, J. T.; Kuhn, J. H.; Palacios, G.",Standard finishing categories for high-throughput sequencing of viral genomes,Rev Sci Tech,35,1,43-52,2016,2010-present,May 25, 2016,27217167,10.20506/rst.35.1.2416,2413,English,http://www.ncbi.nlm.nih.gov/pubmed/27217167,,,,,,Epidemiologie moleculaire; Genomique; Gestion de donnees; Sequencage; Sequencage haut-debit; Typage genomique; Virologie,"Viral genome sequencing has become the cornerstone of almost all aspects of virology. In particular, high-throughput, next-generation viral genome sequencing has become an integral part of molecular epidemiological investigations into outbreaks of viral disease, such as the recent outbreaks of Middle Eastern respiratory syndrome, Ebola virus disease and Zika virus infection. Multiple institutes have acquired the expertise and necessary infrastructure to perform such investigations, as evidenced by the accumulation of thousands of novel viral sequences over progressively shorter time periods. The authors recently proposed a nomenclature comprised of five high-throughput sequencing standard categories to describe the quality of determined viral genome sequences. These five categories (standard draft, high quality, coding complete, complete and finished) cover all levels of viral genome finishing and can be applied to sequences determined by any technology platform or assembly technique.; Publisher: Abstract available from the publisher.; fre; spa",Pubmed,May 30, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Unknown/unclear,Review,No,Yes,1037,Basic and applied biomedical research,Basic research review
1038,"Dredze, Vaccine, 2016",Dredze,"Dredze, M.; Broniatowski, D. A.; Hilyard, K. M.",Zika vaccine misconceptions: A social media analysis,Vaccine,34,30,3441-2,2016,2010-present,May 25, 2016,27216759,10.1016/j.vaccine.2016.05.008,2376,English,http://www.ncbi.nlm.nih.gov/pubmed/27216759,"Human Language Technology Center of Excellence, Johns Hopkins University Baltimore, MD, United States.; Department of Engineering Management and Systems Engineering, The George Washington University Washington, DC, United States. Electronic address: broniatowski@gwu.edu.; Department of Health Promotion and Behavior, College of Public Health University of Georgia Athens, GA, United States.",,,,,,,Pubmed,May 30, 2016,Yes,,No,"Zika, not relevant to causality framework",Scientific (journal) article,Unknown/unclear,Original research,No,Yes,1038,Clinical/epidemiological research,Qualitative study
1039,"Campos, Braz J Infect Dis, 2016",Campos,"Campos, G. C.; Sardi, S. I.; Sarno, M.; Brites, C.","Zika virus infection, a new public health challenge",Braz J Infect Dis,20,3,227-8,2016,2010-present,May 25, 2016,27215946,10.1016/j.bjid.2016.05.001,2307,English,http://www.ncbi.nlm.nih.gov/pubmed/27215946,"Instituto de Ciencias da Saude, Universidade Federal da Bahia, Salvador, BA, Brazil.; Faculdade de Medicina, Universidade Federal da Bahia, Salvador, BA, Brazil.; Faculdade de Medicina, Universidade Federal da Bahia, Salvador, BA, Brazil. Electronic address: crbrites@gmail.com.",,,,,,,Pubmed,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,1039,,
1040,"Kurki, Lakartidningen, 2016",Kurki,"Kurki, L.; Meri, S.",Myggöverförda sjukdomar sprids i takt med globalisering - Behovet av forskning och nya vacciner är stort.,Lakartidningen,113,,,2016,2010-present,May 25, 2016,27219081,,2416,Other,http://www.ncbi.nlm.nih.gov/pubmed/27219081,"Helsingfors Universitet - Helsinki, Finland - Helsinki, Finland.; Haartman-institutet - Avdelningen for bakteriologi och immunologi Helsinki, Finland Haartman-institutet - Avdelningen for bakteriologi och immunologi Helsinki, Finland.",,,,,,"The global burden of mosquito-borne diseases has seen major changes during the last few decades. Viruses like dengue, chikungunya and zika have spread rapidly all around the world. Modern transportation has facilitated the spread of vectors and pathogens to new geographical areas, sometimes resulting in large epidemics in nonimmune populations. Malaria is still an enormous burden to healthcare systems in Sub-Saharan Africa, but significant progress has been made in the global control and elimination of the disease. Climatic, ecological, demographic, social and political changes may affect the complex transmission networks, and there has been much discussion about the possible epidemiological outcomes of such changes. The present article reviews literature on possible reasons behind the shifts in the disease burden, highlighting the complexity of the problem and the need for further research on, improved surveillance of, and public education on mosquitoes and the pathogens they carry, in order to prevent and effectively treat mosquito-borne infections.",Pubmed,May 30, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Unknown/unclear,Review,No,Yes,1040,Clinical/epidemiological research,Epidemiological/clinical review
1041,"PAHO, , 2016",PAHO,PAHO,Epidemiological Update. Zika virus infection - 26 May 2016,,,,,2016,2010-present,May 26, 2016,,,2743,,http://www.paho.org/hq/index.php?option=com_docman&task=doc_view&Itemid=270&gid=34797&lang=en,,United States,Americas,,Public/Government,,,PAHO,May 30, 2016,Yes,,No,"Zika, indirect evidence or other topic",Surveillance report or data,,,No,Yes,1041,Clinical/epidemiological research,Ecological study/outbreak report
1042,"Engel, J Public Health Manag Pract, 2016",Engel,"Engel, J.",Of Mosquito Nets and Condoms: The Zika Virus Challenge,J Public Health Manag Pract,22,4,323-5,2016,2010-present,May 26, 2016,27223311,10.1097/PHH.0000000000000431,2438,English,http://www.ncbi.nlm.nih.gov/pubmed/27223311,"Council of State and Territorial Epidemiologists, Atlanta, Georgia.",,,,,,,Pubmed,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,1042,,
1043,"InVS, Point Epidemiologique CIRE Antilles Guyane, 2016",InVS,InVS,Point epidemio: Emergence du virus zika aux Antilles Guyane : Situation epidemiologique - 26 mai 2016,Point Epidemiologique CIRE Antilles Guyane,20,,,2016,2010-present,May 26, 2016,,,2212,French,http://www.invs.sante.fr/fr/Publications-et-outils/Points-epidemiologiques/Tous-les-numeros/Antilles-Guyane/2016/Situation-epidemiologique-du-virus-Zika-aux-Antilles-Guyane.-Point-au-26-mai-2016,,France,Europe,,Public/Government,,,Institute de veille sanitaire,May 30, 2016,Yes,,No,"Zika, indirect evidence or other topic",Surveillance report or data,,,No,Yes,1043,Clinical/epidemiological research,Ecological study/outbreak report
1044,"Allen, J Public Health Manag Pract, 2016",Allen,"Allen, M.; Blumenstock, J. S.","Public Health Acts to Detect, Respond to, and Prevent the Latest Public Health Threat-Zika Virus Disease",J Public Health Manag Pract,22,4,424-6,2016,2010-present,May 26, 2016,27223315,10.1097/PHH.0000000000000432,2316,English,http://www.ncbi.nlm.nih.gov/pubmed/27223315,"Association of State and Territorial Health Officials, Arlington, Virginia.",,,,,,,Pubmed,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,1044,,
1045,"Rodriguez-Morales, Travel Med Infect Dis, 2016",Rodriguez-Morales,"Rodriguez-Morales, A. J.; Villamil-Gomez, W. E.; Franco-Paredes, C.","The arboviral burden of disease caused by co-circulation and co-infection of dengue, chikungunya and Zika in the Americas",Travel Med Infect Dis,14,3,177-9,2016,2010-present,May 26, 2016,27224471,10.1016/j.tmaid.2016.05.004,2535,English,http://www.ncbi.nlm.nih.gov/pubmed/27224471,"Public Health and Infection Group of Research, Faculty of Health Sciences, Universidad Tecnologica de Pereira, Pereira, Risaralda, Colombia; Colombian Collaborative Network on Zika (RECOLZIKA), Pereira, Risaralda, Colombia. Electronic address: arodriguezm@utp.edu.co.; Colombian Collaborative Network on Zika (RECOLZIKA), Pereira, Risaralda, Colombia; Infectious Diseases and Infection Control Research Group, Hospital Universitario de Sincelejo, Sincelejo, Sucre, Colombia; SUE Caribe, Programa del Doctorado de Medicina Tropical, Universidad del Atlantico, Barranquilla, Colombia.; Colombian Collaborative Network on Zika (RECOLZIKA), Pereira, Risaralda, Colombia; Phoebe Putney Memorial Hospital, Albany, GA, USA; Hospital Infantil de Mexico, Federico Gomez, Mexico D.F., Mexico.",,,,,,,Pubmed,May 30, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,1045,,
1046,"O'Connor, Hosp Health Netw, 2016",O'Connor,"O'Connor, M.",ZIKA PREP. 5 things you should know about Zika,Hosp Health Netw,90,4,"18, 2",2016,2010-present,May 26, 2016,27220167,,2474,English,http://www.ncbi.nlm.nih.gov/pubmed/27220167,,,,,,Humans; *Zika Virus; *Zika Virus Infection,The migration of the Zika virus into North America is posing challenges for health care providers. Here are five things to keep in mind.,Pubmed,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,1046,,
1047,"Rostadmo, Tidsskr Nor Laegeforen, 2016",Rostadmo,"Rostadmo, M.",Zika - more than just bad luck,Tidsskr Nor Laegeforen,136,9,781,2016,2010-present,May 26, 2016,27221166,10.4045/tidsskr.16.0445,2513,English,http://www.ncbi.nlm.nih.gov/pubmed/27221166,,,,,,,,Pubmed,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,1047,,
1048,"Gong, Trends Microbiol, 2016",Gong,"Gong, Z.; Gao, Y.; Han, G. Z.",Zika Virus: Two or Three Lineages?,Trends Microbiol,24,7,521-2,2016,2010-present,May 26, 2016,27220937,10.1016/j.tim.2016.05.002,2404,English,http://www.ncbi.nlm.nih.gov/pubmed/27220937,"Jiangsu Key Laboratory for Microbes and Functional Genomics, Jiangsu Engineering and Technology Research Center for Microbiology, College of Life Sciences, Nanjing Normal University, Nanjing, Jiangsu 210046, China.; Jiangsu Key Laboratory for Microbes and Functional Genomics, Jiangsu Engineering and Technology Research Center for Microbiology, College of Life Sciences, Nanjing Normal University, Nanjing, Jiangsu 210046, China. Electronic address: guanzhu@email.arizona.edu.",,,,,Zika virus; classification; evolution; microcephaly,"Zika virus (ZIKV) infection has become an emerging concern of global public health. Several recent studies provide new insights into the evolution and diversity of ZIKV, with important implications for ongoing surveillance and control measures.",Pubmed,May 30, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,1048,,
1049,"Johansson, N Engl J Med, 2016",Johansson,"Johansson, M. A.; Mier, Y. Teran-Romero L.; Reefhuis, J.; Gilboa, S. M.; Hills, S. L.",Zika and the Risk of Microcephaly,N Engl J Med,,,,2016,2010-present,May 26, 2016,27222919,10.1056/NEJMp1605367,2434,English,http://www.ncbi.nlm.nih.gov/pubmed/27222919,"From the Division of Vector-Borne Diseases (M.A.J., L.M.-T.-R., S.L.H.) and the Division of Congenital and Developmental Disorders (J.R., S.M.G.), Centers for Disease Control and Prevention, Atlanta; and the Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston (M.A.J.).",United States,Americas,United States,,,"Zika virus (ZIKV) infection during pregnancy has been linked to birth defects,1 yet the magnitude of risk remains uncertain. Investigators studying the 2013-2014 Zika outbreak in French Polynesia estimated that the risk of microcephaly due to ZIKV infection in the first trimester of pregnancy was 0.95% (95% confidence interval, 0.34 to 1.91), on the basis of eight microcephaly cases identified retrospectively in a population of approximately 270,000 people with an estimated rate of ZIKV infection of 66%.2 In the current outbreak, thousands of cases of infants with suspected microcephaly or other developmental anomalies of the central nervous system that may . . .",Pubmed,May 30, 2016,Yes,,Yes,,Scientific (journal) article,Unknown/unclear,Original research,Yes,No,912,Clinical/epidemiological research,Modelling study
1050,"Lotufo, Sao Paulo Med J, 2016",Lotufo,"Lotufo, P. A.",Zika epidemic and social inequalities: Brazil and its fate,Sao Paulo Med J,134,2,95-6,2016,2010-present,May 26, 2016,27224278,10.1590/1516-3180.2016.13421602,2429,English,http://www.ncbi.nlm.nih.gov/pubmed/27224278,"Department of Internal Medicine, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil.",,,,,,,Pubmed,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,1050,,
1051,"WHO, , 2016",WHO,WHO,"Zika situation report. Zika virus, Microcephaly and Guillain-Barré syndrome - 26 May 2016",,,,,2016,2010-present,May 26, 2016,,,2696,,http://www.who.int/emergencies/zika-virus/situation-report/26-may-2016/en/,,Switzerland,Europe,,Public/Government,,,WHO,May 30, 2016,Yes,,No,"Zika, indirect evidence or other topic",Surveillance report or data,,,No,Yes,1051,Clinical/epidemiological research,Ecological study/outbreak report
1052,"Wiwanitkit, Braz Oral Res, 2016",Wiwanitkit,"Wiwanitkit, V.",Zika virus infection spread through saliva,Braz Oral Res,30,1,,2016,2010-present,May 26, 2016,27223135,10.1590/1807-3107BOR-2016.vol30.0076,2623,English,http://www.ncbi.nlm.nih.gov/pubmed/27223135,"Surin Rajabhat University, Bangkok, Thailand.",,,,,,,Pubmed,May 30, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,1052,,
1053,"Wiwanitkit, J Chin Med Assoc, 2016",Wiwanitkit,"Wiwanitkit, V.",Zika virus infection: Control and prevention,J Chin Med Assoc,79,7,409,2016,2010-present,May 26, 2016,27221543,10.1016/j.jcma.2016.04.002,2654,English,http://www.ncbi.nlm.nih.gov/pubmed/27221543,"Department of Tropical Medicine, Hainan Medical University, Haikou, Hainan, China; Department of Public Health Curriculum, Surindra Rajabhat University, Mueang Surin District, Surin, Thailand; Department of Community Medicine, Dr. D.Y. Patil University, Pune, Maharashtra, India. Electronic address: wviroj@yahoo.com.",,,,,,,Pubmed,May 30, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,1053,,
1054,"ECDC, , 2016",ECDC,ECDC,Epidemiological update. Outbreaks of Zika virus and complication potentially linked to the Zika virus infection - 27 May 2016,,,,,2016,2010-present,May 27, 2016,,,2264,,http://ecdc.europa.eu/en/press/news/_layouts/forms/News_DispForm.aspx?ID=1415&List=8db7286c-fe2d-476c-9133-18ff4cb1b568&Source=http%3A%2F%2Fecdc.europa.eu%2Fen%2Fhealthtopics%2Fzika_virus_infection%2FPages%2Fepidemiological-updates.aspx,,Sweden,Europe,,Public/Government,,,ECDC,May 30, 2016,Yes,,No,"Zika, indirect evidence or other topic",Surveillance report or data,,,No,Yes,1054,Clinical/epidemiological research,Ecological study/outbreak report
1055,"Yung, Clin Infect Dis, 2016",Yung,"Yung, C. F.; Thoon, K. C.",Guillain-Barre Syndrome and Zika Virus: Estimating Attributable Risk to Inform Intensive Care Capacity Preparedness,Clin Infect Dis,,,,2016,2010-present,May 27, 2016,27225243,10.1093/cid/ciw355,2665,English,http://www.ncbi.nlm.nih.gov/pubmed/27225243,"Infectious Disease Service, Department of Paediatrics, KK Women's and Children's Hospital, Singapore.",Singapore,Asia,Singapore,Industry,,,Pubmed,May 30, 2016,Yes,,Yes,,Scientific (journal) article,Unknown/unclear,Original research,Yes,No,167,Clinical/epidemiological research,Ecological study/outbreak report
1056,"Jin, Clin Vaccine Immunol, 2016",Jin,"Jin, J.; Simmons, G.",Inhibitory antibodies targeting emerging viruses: advancements and mechanisms,Clin Vaccine Immunol,,,,2016,2010-present,May 27, 2016,27226280,10.1128/CVI.00136-16,2402,English,http://www.ncbi.nlm.nih.gov/pubmed/27226280,"Blood Systems Research Institute, San Francisco, California, USA and University of California, San Francisco, California, USA.",,,,,,"From Ebola virus outbreaks in Western Africa, to the introduction of chikungunya and Zika viruses into the Americas, new and neglected viruses continue to emerge and spread around the world. Due to a lack of existing vaccines or specific therapeutics, little other than supportive care and attempts to interrupt transmission can be provided during initial outbreaks. This has prompted a shift in vaccine design and development to identify novel epitopes and mechanisms of protection that may offer a more broad range of protection against groups or whole families of viruses.Receptor-binding domains and other motifs within viral envelope proteins present one excellent opportunity to target communal epitopes shared by related viruses. Similarly, for viruses where envelope participates in driving viral egress from infected cells, shared epitopes need to be identified to guide the development of broadly protective antibodies and vaccines. We will discuss recent advances in our understanding of broadly protective humoral responses for emerging viruses.",Pubmed,May 30, 2016,Yes,,No,"Zika, not relevant to causality framework",Scientific (journal) article,Yes,Review,No,Yes,1056,Basic and applied biomedical research,Basic research review
1057,"Kieny, Nature, 2016",Kieny,"Kieny, M. P.; Moorthy, V.; Bagozzi, D.",Public health: Use open data to curb Zika virus,Nature,533,7604,469,2016,2010-present,May 27, 2016,27225109,10.1038/533469b,2444,English,http://www.ncbi.nlm.nih.gov/pubmed/27225109,"WHO, Geneva, Switzerland.",,,,,*Access to Information; *Biomedical Research/economics; Disclosure; Humans; *Information Dissemination; International Cooperation; Public Health/economics/*methods; Time Factors; World Health Organization; *Zika Virus; *Zika Virus Infection/therapy/virology,,Pubmed,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,1057,,
1058,"Ventura, JAMA Ophthalmol, 2016",Ventura,"Ventura, C. V.; Maia, M.; Travassos, S. B.; Martins, T. T.; Patriota, F.; Nunes, M. E.; Agra, C.; Torres, V. L.; van der Linden, V.; Ramos, R. C.; Rocha, M. A.; Silva, P. S.; Ventura, L. O.; Belfort, R., Jr.",Risk Factors Associated With the Ophthalmoscopic Findings Identified in Infants With Presumed Zika Virus Congenital Infection,JAMA Ophthalmol,,,,2016,2010-present,May 27, 2016,27228275,10.1001/jamaophthalmol.2016.1784,2473,English,http://www.ncbi.nlm.nih.gov/pubmed/27228275,"Altino Ventura Foundation, Recife, Brazil2Pernambuco's Eye Hospital (HOPE), Recife, Brazil3Department of Ophthalmology and Visual Sciences, Paulista School of Medicine, Federal University of Sao Paulo and Vision Institute, Sao Paulo, Brazil.; Department of Ophthalmology and Visual Sciences, Paulista School of Medicine, Federal University of Sao Paulo and Vision Institute, Sao Paulo, Brazil.; Altino Ventura Foundation, Recife, Brazil2Pernambuco's Eye Hospital (HOPE), Recife, Brazil.; Pernambuco's Eye Hospital (HOPE), Recife, Brazil.; Barao de Lucena Hospital, Recife, Brazil.; Oswaldo Cruz University Hospital, Recife, Brazil.",Brazil,Americas,Brazil,,,"Importance: The Zika virus (ZIKV) might cause microcephaly and ophthalmoscopic findings in infants of mothers infected during pregnancy. Objective: To assess and identify possible risk factors for ophthalmoscopic findings in infants born with microcephaly and a presumed clinical diagnosis of ZIKV intrauterine infection. Design, Setting, and Participants: We conducted a cross-sectional study at the Altino Ventura Foundation in Recife, Brazil, that included 40 infants with microcephaly born in Pernambuco state, Brazil, between May and December 2015. Toxoplasmosis, rubella, cytomegalovirus, syphilis, and human immunodeficiency virus were ruled out in all of them. Testing of cerebrospinal fluid for ZIKV using IgM antibody-capture enzyme-linked immunosorbent assay was performed in 24 of 40 infants (60.0%). The infants and mothers underwent ocular examinations. The infants were divided into 2 groups, those with and without ophthalmoscopic alterations, for comparison. Main Outcomes and Measures: Identification of risk factors for ophthalmoscopic findings in infants born with microcephaly and ZIKV intrauterine infection. Results: Among the 40 infants, the mean (SD) age was 2.2 (1.2) months (range, 0.1-7.3 months). Of the 24 infants tested, 100% had positive results for ZIKV infection: 14 of 22 infants (63.6%) from the group with ophthalmoscopic findings and 10 of 18 infants (55.6%) from the group without ophthalmoscopic findings. The major symptoms reported in both groups were rash by 26 mothers (65.0%), fever by 9 mothers (22.5%), headache by 9 mothers (22.5%), and arthralgia by 8 mothers (20.0%). No mothers reported conjunctivitis or other ocular symptoms during pregnancy or presented signs of uveitis at the time of examination. Thirty-seven eyes (46.3%) of 22 infants (55.0%) had ophthalmoscopic alterations. Ten mothers (71.4%) of infants with ocular findings reported symptoms during the first trimester (frequency, 0.48; 95% CI, 0.02-0.67; P = .04). A difference was also observed between the groups of infants with and without ocular findings regarding the cephalic perimeter: mean (SD) of 28.8 (1.7) and 30.3 (1.5), respectively (frequency, -1.50; 95% CI, -2.56 to -0.51; P = .004). Conclusions and Relevance: Ocular involvement in infants with presumed ZIKV congenital infection were more often seen in infants with smaller cephalic diameter at birth and in infants whose mothers reported symptoms during the first trimester.",Pubmed,May 30, 2016,Yes,,Yes,,Scientific (journal) article,Yes,Original research,Yes,Yes,1058,Clinical/epidemiological research,Cross-sectional study
1059,"Hotez, PLoS Negl Trop Dis, 2016",Hotez,"Hotez, P. J.",Zika in the United States of America and a Fateful 1969 Decision,PLoS Negl Trop Dis,10,5,e0004765,2016,2010-present,May 27, 2016,27227971,10.1371/journal.pntd.0004765,2419,English,http://www.ncbi.nlm.nih.gov/pubmed/27227971,"Sabin Vaccine Institute and Texas Children's Hospital Center for Vaccine Development, National School of Tropical Medicine, Baylor College of Medicine, Houston, Texas, United States of America.; James A Baker III Institute for Public Policy, Rice University, Houston, Texas, United States of America.; Department of Biology, Baylor University, Waco, Texas, United States of America.",,,,,,The United States Gulf Coast's current risk to Zika transmitted by Aedes aegypti mosquitoes can be traced back to some important federal health policy decisions made during the 1960s.,Pubmed,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,1059,,
1060,"Malkki, Nat Rev Neurol, 2016",Malkki,"Malkki, H.",CNS infections: Mouse studies confirm the link between Zika virus infection and microcephaly,Nat Rev Neurol,12,7,369,2016,2010-present,May 28, 2016,27231186,10.1038/nrneurol.2016.78,2418,English,http://www.ncbi.nlm.nih.gov/pubmed/27231186,,,,,,,,Pubmed,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,1060,,
1061,"Duarte, Rev Bras Ginecol Obstet, 2016",Duarte,"Duarte, G.",Challenges of Zika Virus Infection in Pregnant Women,Rev Bras Ginecol Obstet,,,,2016,2010-present,May 28, 2016,27232529,10.1055/s-0036-1584206,2466,English,http://www.ncbi.nlm.nih.gov/pubmed/27232529,"Department of Gynecology and Obstetrics, Faculdade de Medicina de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto, SP, Brazil.",,,,,,,Pubmed,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,1061,,
1062,"Rochat, Matern Child Health J, 2016",Rochat,"Rochat, R. W.",Commentary on Obstetric Care in Rural Georgia,Matern Child Health J,20,7,1321-2,2016,2010-present,May 28, 2016,27230287,10.1007/s10995-016-2024-y,2489,English,http://www.ncbi.nlm.nih.gov/pubmed/27230287,"Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA. rrochat@emory.edu.",,,,,Family planning; Georgia; Larc; Midwifery; Obstetric care; Policy; Rural; Zika,This is an invited commentary on five articles on obstetric care in rural Georgia.,Pubmed,May 30, 2016,Yes,,No,Unrelated to Zika virus,Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,1062,,
1063,"Akiner, PLoS Negl Trop Dis, 2016",Akiner,"Akiner, M. M.; Demirci, B.; Babuadze, G.; Robert, V.; Schaffner, F.","Correction: Spread of the Invasive Mosquitoes Aedes aegypti and Aedes albopictus in the Black Sea Region Increases Risk of Chikungunya, Dengue, and Zika Outbreaks in Europe",PLoS Negl Trop Dis,10,5,e0004764,2016,2010-present,May 28, 2016,27232603,10.1371/journal.pntd.0004764,2325,English,http://www.ncbi.nlm.nih.gov/pubmed/27232603,,,,,,,[This corrects the article DOI: 10.1371/journal.pntd.0004664.].,Pubmed,May 30, 2016,No,Duplicate of existing record,,,,,,,,,,
1064,"Barreiro, AIDS Rev, 2016",Barreiro,"Barreiro, P.",First Case of Zika Virus Infection in a HIV+ Patient,AIDS Rev,18,2,112,2016,2010-present,May 28, 2016,27232506,,2363,English,http://www.ncbi.nlm.nih.gov/pubmed/27232506,"Tropical & Travel Medicine Unit, Hospital Carlos III-La Paz, Madrid, Spain.",,,,,,"Zika virus is an enveloped, single-stranded RNA virus that belongs to the flavivirus genre. As with arbovirus, it is transmitted by arthropods (mosquitoes), both Aedes aegypti (urban) and albopictus (rural). Zika virus was first isolated in 1947 from monkeys in Uganda. The first human cases were reported in 1952 in East Africa. Outbreaks were reported in Micronesia (2007), Polynesia (2013), and Chile (2014). Both diagnostic procedures and therapeutics are poorly developed. Serological tests cross-react with dengue and there are neither specific antivirals nor vaccines.",Pubmed,May 30, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Unknown/unclear,Original research,No,Yes,1064,Clinical/epidemiological research,Case report
1065,"Massey, J Neurol, 2016",Massey,"Massey, T. H.; Robertson, N. P.",Zika virus and neurology: proving cause and effect,J Neurol,263,6,1255-7,2016,2010-present,May 28, 2016,27230852,10.1007/s00415-016-8165-5,2403,English,http://www.ncbi.nlm.nih.gov/pubmed/27230852,"Division of Psychological Medicine and Clinical Neuroscience, Department of Neurology, Cardiff University, University Hospital of Wales, Heath Park, Cardiff, CF14 4XN, UK.; Division of Psychological Medicine and Clinical Neuroscience, Department of Neurology, Cardiff University, University Hospital of Wales, Heath Park, Cardiff, CF14 4XN, UK. robertsonnp@cardiff.ac.uk.",,,,,,,Pubmed,May 30, 2016,Yes,,No,"Zika, not relevant to causality framework",Scientific (journal) article,Unknown/unclear,Review,No,Yes,1065,Clinical/epidemiological research,Epidemiological/clinical review
1066,"Leao, Oral Dis, 2016",Leao,"Leao, J. C.; Gueiros, L. A.; Lodi, G.; Robinson, N. A.; Scully, C.",Zika virus: oral healthcare implications,Oral Dis,,,,2016,2010-present,May 28, 2016,27232461,10.1111/odi.12512,2420,English,http://www.ncbi.nlm.nih.gov/pubmed/27232461,"Oral Medicine Unit, Departamento de Clinica e Odontologia Preventiva, Universidade Federal de Pernamuco, Recife, Brazil.; Dipartimento di Scienze Biomediche, Chirurgiche e Odontoiatriche. Universita degli Studi di Milano.; Discipline of Oral and Maxillofacial Surgery, Faculty of Dentistry, National University of Singapore, Singapore.; WHO Collaborating Centre for Oral Health, General Health; and UCL, London, UK.",,,,,Arboviruses; Dental; Epidemiology; Oral; Zika virus,"Zika virus (ZIKV) infection has been recognized since 1947, but just recently it became a worldwide major public health problem. The most common features of ZIKV infection are fever, cutaneous rash, arthralgia, and conjunctivitis but most affected patients with the clinical disease present with only mild symptoms. However, severe neurologic complications have been described: there is an occasional association with Guillain-Barre syndrome, and emerging data indicate an association between vertical transmission of ZIKV infection and microcephaly but no specific orofacial manifestations have yet been reported. ZIKV is present in body fluids and has also been demonstrated in the saliva, but there is as yet no reliable evidence to support ZIKV transmission via this pathway. Transmission in oral healthcare should be effectively prevented using standard infection control measures. There are currently no specific treatments for ZIKA virus disease and no vaccines available, so prevention of ZIKV is based on vector control. This article is protected by copyright. All rights reserved.",Pubmed,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,1066,,
1067,"van den Berg, Ned Tijdschr Geneeskd, 2016",van den Berg,"van den Berg, B.; van den Beukel, J. C.; Alsma, J.; van der Eijk, A. A.; Ruts, L.; van Doorn, P. A.; Jacobs, B. C.; Simon, C. C.",[Guillain-Barre syndrome following infection with the Zika virus],Ned Tijdschr Geneeskd,160,0,D155,2016,2010-present,May 28, 2016,27229696,,2559,Other,http://www.ncbi.nlm.nih.gov/pubmed/27229696,"Erasmus MC, Rotterdam.",Netherlands,Europe,Netherlands,,,"BACKGROUND: Guillain-Barre syndrome (GBS) has been identified as a possible complication of infections with the Zika virus (ZIKV) in the current epidemic in Central and South America. Here we describe the first case of GBS in the Netherlands following a ZIKV infection. CASE DESCRIPTION: A 60-year-old woman presented with diarrhoea, fever and an unsteady gait after returning from Surinam. As creatine kinase levels were raised the initial diagnosis was rhabdomyolysis associated with myositis or medication use. However, creatine kinase levels normalized rapidly and the patient developed muscle weakness, sensory disturbances, hyporeflexia in her limbs and facial diplegia. The diagnosis GBS was considered, which was supported by spinal fluid investigation and electromyography. ZIKV was detected in serum and urine. The patient was treated with intravenous immunoglobulins, and recovered. CONCLUSION: This patient developed GBS following a recent ZIKV infection acquired in Suriname. A causal relation between ZIKV infection and GBS, however, has not yet been demonstrated.",Pubmed,May 30, 2016,Yes,,Yes,,Scientific (journal) article,Unknown/unclear,Original research,Yes,No,1028,Clinical/epidemiological research,Case report
1068,"Eyer, J Infect Dis, 2016",Eyer,"Eyer, L.; Nencka, R.; Huvarova, I.; Palus, M.; Joao Alves, M.; Gould, E. A.; De Clercq, E.; Ruzek, D.",Nucleoside inhibitors of Zika virus,J Infect Dis,,,,2016,2010-present,May 29, 2016,27234417,10.1093/infdis/jiw226,2388,English,http://www.ncbi.nlm.nih.gov/pubmed/27234417,"Department of Virology, Veterinary Research Institute, Hudcova 70, CZ-62100 Brno, Czech Republic.; Institute of Organic Chemistry and Biochemistry, The Czech Academy of Sciences, Fleming Sq. 2, CZ-16610 Prague, Czech Republic.; Department of Virology, Veterinary Research Institute, Hudcova 70, CZ-62100 Brno, Czech Republic Institute of Parasitology, Biology Centre of the Czech Academy of Sciences, and Faculty of Science, University of South Bohemia, Branisovska 31, CZ-37005 Ceske Budejovice, Czech Republic.; CEVDI/INSA National Institute of Health Dr. Ricardo Jorge, Av. Liberdade 5, 2965 575 Aguas de Moura, Portugal.; Aix Marseille Universite, IRD French Institute of Research for Development, EHESP French School of Public Health, EPV UMR_D 190 'Emergence des Pathologies Virales', 13385, Marseille, France.; Rega Institute for Medical Research, KU Leuven, Minderbroedersstraat 10, B-3000 Leuven, Belgium.; Department of Virology, Veterinary Research Institute, Hudcova 70, CZ-62100 Brno, Czech Republic Institute of Parasitology, Biology Centre of the Czech Academy of Sciences, and Faculty of Science, University of South Bohemia, Branisovska 31, CZ-37005 Ceske Budejovice, Czech Republic ruzekd@paru.cas.cz.",,,,,,"There is growing evidence that Zika virus (ZIKV) can cause devastating infant brain defects and other neurological disorders in humans. However, no specific antiviral therapy is available at present. We tested a series of 2'-C- or 2'-O-methyl substituted nucleosides, 2'-C-fluoro-2'-C-methyl substituted nucleosides, 3'-O-methyl substituted nucleosides, 3'-deoxynucleosides, derivatives with 4'-C-azido substitution, heterobase modified nucleosides, and neplanocins for their ability to inhibit ZIKV replication in cell culture. Antiviral activity was identified when 2'-C-methylated nucleosides were tested, suggesting that these compounds might represent promising lead candidates for further development of specific antivirals against ZIKV.",Pubmed,May 30, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Original research,No,Yes,1068,Basic and applied biomedical research,In vitro experiment
1069,"Metz, Methods Mol Biol, 2016",Metz,"Metz, S. W.; Pijlman, G. P.",Production of Chikungunya Virus-Like Particles and Subunit Vaccines in Insect Cells,Methods Mol Biol,1426,,297-309,2016,2010-present,May 29, 2016,27233282,10.1007/978-1-4939-3618-2_27,2515,English,http://www.ncbi.nlm.nih.gov/pubmed/27233282,"Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC, USA.; Laboratory of Virology, Wageningen University, Droevendaalsesteeg 1, 6708 NW, Wageningen, The Netherlands.; Laboratory of Virology, Wageningen University, Droevendaalsesteeg 1, 6708 NW, Wageningen, The Netherlands. gorben.pijlman@wur.nl.",,,,,Baculovirus; Chikungunya virus; Insect cells; Production and purification; Secreted E1 and E2; Virus-like particles,"Chikungunya virus is a reemerging human pathogen that causes debilitating arthritic disease in humans. Like dengue and Zika virus, CHIKV is transmitted by Aedes mosquitoes in an epidemic urban cycle, and is now rapidly spreading through the Americas since its introduction in the Caribbean in late 2013. There are no licensed vaccines or antiviral drugs available, and only a few vaccine candidates have passed Phase I human clinical trials. Using recombinant baculovirus expression technology, we have generated CHIKV glycoprotein subunit and virus-like particle (VLP) vaccines that are amenable to large scale production in insect cells. These vaccines, in particular the VLPs, have shown high immunogenicity and protection against CHIKV infection in different animal models of CHIKV-induced disease. Here, we describe the production, purification, and characterization of these potent CHIKV vaccine candidates.",Pubmed,May 30, 2016,No,Unrelated to Zika virus,,,Scientific (journal) article,Yes,Original research,No,Yes,1069,Basic and applied biomedical research,In vitro experiment
1070,"de Miranda, Ophthalmology, 2016",de Miranda,"de Miranda, H. A., 2nd; Costa, M. C.; Frazao, M. A.; Simao, N.; Franchischini, S.; Moshfeghi, D. M.",Expanded Spectrum of Congenital Ocular Findings in Microcephaly with Presumed Zika Infection,Ophthalmology,,,,2016,2010-present,May 30, 2016,27236271,10.1016/j.ophtha.2016.05.001,2553,English,http://www.ncbi.nlm.nih.gov/pubmed/27236271,"Ophthalmic Telemedicine Santa Casa of Sao Paulo, Sao Paulo, Brazil.; Department of Ophthalmology, University of Sao Paulo, Sao Paulo, Brazil.; Department of Ophthalmology, University of Santo Amaro, Sao Paulo, Brazil.; Department of Ophthalmology, Horngren Family Vitreoretinal Center, Byers Eye Institute, Stanford University School of Medicine, Palo Alto, California. Electronic address: dariusm@stanford.edu.",Brazil,Americas,United States,,,"PURPOSE: To describe the ocular findings of 3 cases of suspected congenital Zika viral infection with microcephaly and maculopathy. DESIGN: Retrospective, consecutive case series. PARTICIPANTS: Three male infants born in northern Brazil whose mothers demonstrated a viral syndrome during the first trimester and who subsequently were born with microcephaly. METHODS: Observational report of macular findings. MAIN OUTCOME MEASURES: Continued observation. RESULTS: Three male infants were born with microcephaly to mothers who had a viral syndrome during the first trimester of gestation in an area that subsequently has demonstrated epidemic Zika infection, a flavivirus related to Dengue. Ocular examination was performed. All 6 eyes demonstrated a pigmentary maculopathy ranging from mild to pronounced. In 4 eyes, well-delineated macular chorioretinal atrophy with a hyperpigmented ring developed. Three eyes demonstrated vascular tortuosity and 2 eyes demonstrated a pronounced early termination of the retinal vasculature on photographic evaluation. Two eyes demonstrated a washed out peripheral retina with a hypolucent spot. One eye had scattered subretinal hemorrhages external to the macula. Finally, 1 eye demonstrated peripheral pigmentary changes and clustered atrophic lesions resembling grouped congenital albinotic spots (polar bear tracks). CONCLUSIONS: Zika virus has been linked to microcephaly in children of mothers with a viral syndrome during the first trimester of pregnancy. Ocular findings previously described a pigmentary retinopathy and atrophy that now can be expanded to include torpedo maculopathy, vascular changes, and hemorrhagic retinopathy. Ophthalmologic screening guidelines need to be defined to determine which children would benefit from newborn screening in affected regions.",Pubmed,May 30, 2016,Yes,,Yes,,Scientific (journal) article,Yes,Original research,No,Yes,1070,Clinical/epidemiological research,Case series
1071,"Maharajan, Clin Rev Allergy Immunol, 2016",Maharajan,"Maharajan, M. K.; Ranjan, A.; Chu, J. F.; Foo, W. L.; Chai, Z. X.; Lau, E. Y.; Ye, H. M.; Theam, X. J.; Lok, Y. L.",Zika Virus Infection: Current Concerns and Perspectives,Clin Rev Allergy Immunol,,,,2016,2010-present,May 30, 2016,27236440,10.1007/s12016-016-8554-7,2370,English,http://www.ncbi.nlm.nih.gov/pubmed/27236440,"Department of Pharmacy Practice, School of Pharmacy, International Medical University, Kuala Lumpur, 57000, Malaysia. kanpharm2002@gmail.com.; Department of Pharmacy Practice, School of Pharmacy, International Medical University, Kuala Lumpur, 57000, Malaysia.",,,,,Cytokines; Diagnosis; Management; Transmission; Zika virus,"The Zika virus outbreaks highlight the growing importance need for a reliable, specific and rapid diagnostic device to detect Zika virus, as it is often recognized as a mild disease without being identified. Many Zika virus infection cases have been misdiagnosed or underreported because of the non-specific clinical presentation. The aim of this review was to provide a critical and comprehensive overview of the published peer-reviewed evidence related to clinical presentations, various diagnostic methods and modes of transmission of Zika virus infection, as well as potential therapeutic targets to combat microcephaly. Zika virus is mainly transmitted through bites from Aedes aegypti mosquito. It can also be transmitted through blood, perinatally and sexually. Pregnant women are advised to postpone or avoid travelling to areas where active Zika virus transmission is reported, as this infection is directly linked to foetal microcephaly. Due to the high prevalence of Guillain-Barre syndrome and microcephaly in the endemic area, it is vital to confirm the diagnosis of Zika virus. Zika virus infection had been declared as a public health emergency and of international concern by the World Health Organisation. Governments and agencies should play an important role in terms of investing time and resources to fundamentally understand this infection so that a vaccine can be developed besides raising awareness.",Pubmed,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Yes,Review,No,Yes,1071,Clinical/epidemiological research,Epidemiological/clinical review
1072,"Alvarado-Socarras, Med Clin (Barc), 2016",Alvarado-Socarras,"Alvarado-Socarras, J. L.; Sepulveda-Arias, J. C.; Zambrano, L. I.; Rodriguez-Morales, A. J.",[Relevance of laboratory diagnosis of Zika during pregnancy and its possible association with Guillain-Barre syndrome],Med Clin (Barc),,,,2016,2010-present,May 30, 2016,27236614,10.1016/j.medcli.2016.03.044,2333,Spanish,http://www.ncbi.nlm.nih.gov/pubmed/27236614,"Red Colombiana de Colaboracion en Zika (RECOLZIKA), Pereira, Risaralda, Colombia; Organizacion Latinoamericana para el Fomento de la Investigacion en Salud (OLFIS), Bucaramanga, Santander, Colombia; Unidad de Neonatologia, Departamento de Pediatria, Fundacion Cardiovascular de Colombia, Floridablanca, Santander, Colombia.; Red Colombiana de Colaboracion en Zika (RECOLZIKA), Pereira, Risaralda, Colombia; Grupo de Investigacion Infeccion e Inmunidad, Facultad de Ciencias de la Salud, Universidad Tecnologica de Pereira, Pereira, Risaralda, Colombia.; Red Colombiana de Colaboracion en Zika (RECOLZIKA), Pereira, Risaralda, Colombia; Facultad de Ciencias Medicas, Universidad Nacional Autonoma de Honduras, Tegucigalpa, Honduras; Escola Paulista de Medicina, Universidade Federal de Sao Paulo (UNIFESP-EPM), Sao Paulo, Brasil.; Red Colombiana de Colaboracion en Zika (RECOLZIKA), Pereira, Risaralda, Colombia; Organizacion Latinoamericana para el Fomento de la Investigacion en Salud (OLFIS), Bucaramanga, Santander, Colombia; Grupo de Investigacion Infeccion e Inmunidad, Facultad de Ciencias de la Salud, Universidad Tecnologica de Pereira, Pereira, Risaralda, Colombia; Grupo de Investigacion Salud Publica e Infeccion, Facultad de Ciencias de la Salud, Universidad Tecnologica de Pereira, Pereira, Risaralda, Colombia. Electronic address: arodriguezm@utp.edu.co.",,,,,,,Pubmed,May 30, 2016,Yes,,No,"Zika, not relevant to causality framework",Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,Yes,No,425,,
1073,"Mukhopadhyay, bioRxiv, 2016",Mukhopadhyay,"Mukhopadhyay, Mayukh; Bhaumik, Parama",3D perception of maximum density zone on Ramachandran plots for Zika virus protein structures,bioRxiv,,,53074,2016,2010-present,,,10.1101/053074,2201,English,http://biorxiv.org/content/early/2016/05/12/053074,,,,,,,"The Ramachandran plot is among the most central concepts in structural biology which uses torsion angles to describe polypeptide and protein conformation. To help visualize the features of high-fidelity Ramachandran plots, it is helpful to look beyond the common two-dimensional psi-phi-plot, which for a large dataset does not serve very well to convey the true nature of the distribution. In particular, when a large subset of the observations is found very narrowly distributed within one small region, this is not well seen in the simple plot because the data points congest one another. Zika Virus (ZIKV) protein databank has been chosen as specimen for analysis. This is because the structure, tropism, and pathogenesis of ZIKV are largely unknown and are the focus of current investigations in an effort to address the need for rapid development of vaccines and therapeutics. After a brief survey on Zika Virus, it is shown that when a dense dataset of ZIKV protein databank is passed through a colour-coded scaled algorithm, a three dimensional plot gets generated which gives a much more compelling impression of the proportions of residues in the different parts of the protein rather than representing it in a normal two dimensional psi-phi plot.",BiorXiv,May 30, 2016,Yes,,No,"Zika, not relevant to causality framework",Scientific (journal) article,No,Original research,No,Yes,1073,Basic and applied biomedical research,Biochemical/protein structure studies
1074,"Evans, arXiv, 2016",Evans,"Evans, Dan; Nijhout, Fred; Parens, Raphael; Morales, Alfredo J.; Bar-Yam, Yaneer",A Possible Link Between Pyriproxyfen and Microcephaly,arXiv,,,,2016,2010-present,,,,2184,,http://arxiv.org/abs/1604.03834,,United States,Americas,United States,Not reported/unknown,Quantitative Biology - Biomolecules; Quantitative Biology - Neurons and Cognition; Quantitative Biology - Quantitative Methods; Quantitative Biology - Tissues and Organs,"The Zika virus is the primary suspect in the large increase in microcephaly cases in 2015-6 in Brazil, however its role is unconfirmed despite individual cases of viral infections found in neural tissue. Here we consider the alternative that the insecticide pyriproxyfen, used in Brazilian drinking water for mosquito control, may actually be the cause. Pyriproxifen is an analog of juvenile hormone, which corresponds in mammals to regulatory molecules including retinoic acid, a vitamin A metabolite, with which it has cross-reactivity and whose application during development causes microcephaly. Methoprene, another juvenile hormone analog approved as an insecticide has metabolites that bind to the retinoid X receptor, and causes developmental disorders in mammals. Isotretinoin is another example of a retinoid causing microcephaly in human babies via activation of the retinoid X receptor. Moreover, tests of pyriproxyfen by the manufacturer, Sumitomo, widely quoted as giving no evidence for developmental toxicity, actually found some evidence for such an effect, including low brain mass and arhinencephaly--incomplete formation of the anterior cerebral hemispheres--in rat pups. Finally, the pyriproxyfen use in Brazil is unprecedented--it has never before been applied to a water supply on such a scale. Claims that it is not being used in Recife, the epicenter of microcephaly cases, do not distinguish the metropolitan area of Recife, where it is widely used, and the municipality, where it is not. Given this combination of information we strongly recommend that the use of pyriproxyfen in Brazil be suspended pending further investigation.",ArXiv,May 30, 2016,Yes,,No,"Zika, indirect evidence or other topic",Scientific (journal) article,No,Review,No,Yes,1074,Basic and applied biomedical research,Basic research review
1075,"Hanaoka, bioRxiv, 2016",Hanaoka,"Hanaoka, Mauro M.; Kanas, Alexandre Fligelman; Braconi, Carla Torres; Mendes, Erica Araujo; Santos, Robert Andreata; Ferreira, Luis Carlos de Souza; Cunha, Marielton dos Passos; Beltrao-Braga, Patricia; Dias, Joao Leonardo Mendonca; Polonio, Carolina Manganeli; Andrade, David Anibal Garrido; de Freitas, Carla Longo; Rossato, Cristiano; Brandao, Wesley Nogueira; Peron, Jean Pierre Schatzmann; Filho, Antonio Gomes Amorim; Andrade, Joelma Queiroz; Francisco, Rossana Pulcineli Vieira; Kok, Fernando; Suzuki, Lisa; Leite, Claudia da Costa; Lucato, Leandro Tavares; Sall, Amadou Alpha; Zanotto, Paolo Marinho de Andrade",A Zika virus-associated microcephaly case with background exposure to STORCH agents,bioRxiv,,,52340,2016,2010-present,,,10.1101/052340,2189,English,http://biorxiv.org/content/early/2016/05/10/052340,,Brazil,Americas,Brazil,Not reported/unknown,,"We present a case of microcephaly associated with Zika virus (ZIKV) in a chronological, multimodal imaging approach, illustrating the hallmarks of this disease on intrauterine morphological ultrasound, transfontanelar ultrasound, computed tomography (CT) and magnetic resonance imaging (MRI). We also determined the serological e immunological status of the mother and newborn. Noticeably, there was evidence for maternal infection by ZIKV, cytomegalovirus (CMV), herpes simplex virus (HSV), dengue virus (DENV) and Toxoplasma gondii, which indicates a possible role of previous exposures to STORCH agents and possibly comorbidities in the severe fetal congenital manifestation.",BiorXiv,May 30, 2016,Yes,,Yes,,Scientific (journal) article,No,Original research,No,Yes,1075,Clinical/epidemiological research,Case report
1076,"Westbrook, bioRxiv, 2016",Westbrook,"Westbrook, Alexandra M.; Lucks, Julius B.",Achieving large dynamic range control of gene expression with a compact RNA transcription-translation regulator,bioRxiv,,,55327,2016,2010-present,,,10.1101/055327,2257,English,http://biorxiv.org/content/early/2016/05/24/055327,,,,,,,"RNA transcriptional regulators are emerging as versatile components for genetic circuit construction. However, RNA transcriptional regulators suffer from incomplete repression, making their dynamic range less than that of their protein counterparts. This incomplete repression can cause expression leak, which impedes the construction of larger RNA synthetic regulatory networks. Here we demonstrate how naturally derived antisense RNA-mediated transcriptional regulators can be configured to regulate both transcription and translation in a single compact RNA mechanism that functions in Escherichia coli. Using in vivo gene expression assays, we show that a combination of transcriptional termination and RBS sequestration increases repression from 85% to 98% and activation from 10 fold to over 900 fold in response to cognate antisense RNAs. We also show that orthogonal versions of this mechanism can be created through engineering minimal antisense RNAs. Finally, to demonstrate the utility of this dual control mechanism, we use it to reduce circuit leak in an RNA-only transcriptional cascade that activates gene expression as a function of a small molecule input. We anticipate these regulators will find broad use as synthetic biology moves beyond parts engineering to the design and construction of larger and more sophisticated circuits.",BiorXiv,May 30, 2016,No,Unrelated to Zika virus,,,Scientific (journal) article,No,Original research,No,Yes,1076,Basic and applied biomedical research,Other basic research
1077,"Fitzgibbon, arXiv, 2016",Fitzgibbon,"Fitzgibbon, W.; Morgan, J.; Webb, G.",An Outbreak Vector-host Epidemic Model with Spatial Structure: The 2015 Zika Outbreak in Rio de Janeiro,arXiv,,,,2016,2010-present,,,,2245,,http://arxiv.org/abs/1605.08726; files/1461/1605.html,,,,,,Quantitative Biology - Populations and Evolution,A deterministic model is developed for the spatial spread of an epidemic disease in a geographical setting. The model is focused on an epidemic outbreak that initiates from a small number of cases in a small sub-region of the geographical setting. The partial differential equations of the model are analyzed and proven to be well-posed. The model is illustrated with numerical simulations that reveal epidemic outcomes correlated to the spatially dependent parameters of the model and the spatially dependent epidemic basic reproduction number. The model is applied to the 2015 Zika outbreak in the Rio de Janeiro Municipality.,ArXiv,May 30, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,No,Original research,No,Yes,1077,Clinical/epidemiological research,Modelling study
1078,"Pagete, arXiv, 2016",Pagete,"Pagete, Daisy E.",An end-to-end assembly of the Aedes aegypti genome,arXiv,,,,2016,2010-present,,,,2196,,http://arxiv.org/abs/1605.04619; files/1465/1605.html,,,,,,Quantitative Biology - Genomics,"We present an end-to-end genome assembly of a female Aedes aegypti mosquito, which spreads viral diseases such as yellow fever, dengue, chikungunya, and Zika to humans. The assembly is based on an earlier genome published in 2007 and improved in 2013. The new assembly has a scaffold N50 of 419Mb, with 96.9% of the ungapped sequence anchored to chromosomes. We used the new assembly to examine the conservation of A. aegypti chromosomes. Our results suggest that synteny is strongly conserved between Ae. aegypti and An. gambiae. Comparison to D. melanogaster highlights the extent to which the identity of entire chromosome arms is preserved across dipterans.",ArXiv,May 30, 2016,No,Unrelated to Zika virus,,,Scientific (journal) article,No,Original research,No,Yes,1078,Basic and applied biomedical research,Sequence analysis and phylogenetics
1079,"Delvecchio, bioRxiv, 2016",Delvecchio,"Delvecchio, Rodrigo; Higa, Luiza M.; Pezzuto, Paula; Valadao, Ana Luiza; Garcez, Patricia P.; Monteiro, Fabio L.; Loiola, Erick C.; Rehen, Stevens; Campanati, Loraine; de Aguiar, Renato Santana; Tanuri, Amilcar",Chloroquine inhibits Zika Virus infection in different cellular models,bioRxiv,,,51268,2016,2010-present,,,10.1101/051268,2173,English,http://biorxiv.org/content/early/2016/05/02/051268; files/1520/051268.html,,,,,,,"Zika virus (ZIKV) infection in utero might lead to microcephaly and other congenital defects. In adults, cases of Guillain-Barré syndrome and meningoencephalitis associated with ZIKV infection have been reported, but to date, no specific therapy is available. There is an urgency for the discovery of antiviral agents capable of inhibiting viral replication and its deleterious effects. Chloroquine is widely used as an antimalarial drug and anti-inflammatory agent that also shows antiviral activity against several viruses. Here we show that chloroquine exhibits antiviral activity against ZIKV in VERO, human brain microvascular endothelial, and neural stem cells. We demonstrated in vitro that chloroquine reduces the number of ZIKV-infected cells, virus production and cell death promoted by ZIKV infection without cytotoxic effects. Our results suggest that chloroquine is a promising candidate for ZIKV clinical trials, since it is already approved for clinical use and can be safely administered to pregnant woman.",BiorXiv,May 30, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,No,Original research,No,Yes,1079,Basic and applied biomedical research,In vitro experiment
1080,"Garcez, PeerJ Preprints, 2016",Garcez,"Garcez, P. P.; Juliana Minardi Nascimento; Janaina Mota de Vasconcelos; Rodrigo Madeiro  da  Costa; Rodrigo  Delvecchio; Pablo  Trindade; Erick  Correia Loiola; Luiza  M.  Higa; Juliana",Combined  proteome  and  transcriptome  analyses  reveal  that  Zika  virus circulating  in  Brazil  alters  cell  cycle  and  neurogenic  programmes  in  human neurospheres,PeerJ Preprints,,,,2016,2010-present,,,https://doi.org/10.7287/peerj.preprints.2033v1,2728,English,https://peerj.com/preprints/2033/,,Brazil,Americas,Brazil,Mixed,,,PeerJ Preprints,May 30, 2016,Yes,,Yes,,Scientific (journal) article,No,Original research,No,Yes,1080,Basic and applied biomedical research,In vitro experiment
1081,"Ramaiah, bioRxiv, 2016",Ramaiah,"Ramaiah, Arunachalam; Dai, Lei; Contreras, Deisy; Sinha, Sanjeev; Sun, Ren; Arumugaswami, Vaithilingaraja",Comparative analysis of protein evolution and RNA structural changes in the genome of pre-epidemic and epidemic Zika virus,bioRxiv,,,50278,2016,2010-present,,,10.1101/050278,2207,English,http://biorxiv.org/content/early/2016/04/26/050278,,,,,,,"Zika virus (ZIKV) infection is associated with microcephaly, neurological disorders and poor pregnancy outcome and no vaccine is available. Although ZIKV was first discovered in 1947, the exact mechanism of virus replication and pathogenesis still remains unknown. Recent outbreaks of Zika virus in the Americas clearly suggest a better adaptation of viral strains to human host. Understanding the conserved and adaptive features in the evolution of ZIKV genome will reveal the molecular mechanism of virus replication and host adaptation. Here, we show comprehensive analysis of protein evolution and changes in RNA secondary structures of ZIKV strains including the current 2015-16 outbreak. To identify the constraints on ZIKV evolution, selection pressure at individual codons, immune epitopes, co-evolving sites, and RNA structures were analyzed. The proteome of current 2015/16 epidemic ZIKV strains of Asian genotype is found to be genetically conserved due to genome-wide negative selection on codons, with limited positive selection. Predicted RNA structures at the 5-prime and 3-prime ends of ZIKV strains reveal substantial changes such as an additional stem loop which makes it similar to that of Yellow Fever Virus. Concisely, the targeted changes at both the amino acid and the RNA levels contribute to the better adaptation of ZIKV strains to human host with an enhanced neurotropism.",BiorXiv,May 30, 2016,Yes,,No,"Zika, indirect evidence or other topic",Scientific (journal) article,No,Original research,No,Yes,1081,Basic and applied biomedical research,Sequence analysis and phylogenetics
1082,"Basak, Current Computer-Aided Drug Design, 2016",Basak,"Basak, S. C.; Nandy, A.","Computer-Assisted Approaches as Decision Support Systems in the Overall Strategy of Combating Emerging Diseases: Some Comments Regarding Drug Design, Vaccinomics, and Genomic Surveillance of the Zika Virus",Current Computer-Aided Drug Design,12,1,02. Apr,2016,2010-present,,,10.2174/1573409912999160315115502,2617,English,<Go to ISI>://WOS:000372550900001,"Univ Minnesota, Nat Resources Res Inst, Duluth, MN 55811 USA; Univ Minnesota, Dept Chem & Biochem, Duluth, MN 55811 USA; Ctr Interdisciplinary Res & Educ, Jodhpur Pk, Kolkata 700068, India",,,,,mathematical descriptors,,Embase,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,1082,,
1083,"Paul, bioRxiv, 2016",Paul,"Paul, Lauren M.; Carlin, Eric R.; Jenkins, Meagan M.; Tan, Amanda L.; Barcellona, Carolyn M.; Nicholson, Cindo O.; Trautmann, Lydie; Michael, Scott F.; Isern, Sharon",Dengue Virus Antibodies Enhance Zika Virus Infection,bioRxiv,,,50112,2016,2010-present,,,10.1101/050112,2171,English,http://biorxiv.org/content/early/2016/04/25/050112,,United States,Americas,United States,,,"Background For decades, human infections with Zika virus (ZIKV), a mosquito-transmitted flavivirus, were sporadic, associated with mild disease, and went underreported since symptoms were similar to other acute febrile diseases endemic in the same regions. Recent reports of severe disease associated with ZIKV, including Guillain-Barre syndrome and severe fetal abnormalities, have greatly heightened awareness. Given its recent history of rapid spread in immune naive populations, it is anticipated that ZIKV will continue to spread in the Americas and globally in regions where competent Aedes mosquito vectors are found. Globally, dengue virus (DENV) is the most common mosquito-transmitted human flavivirus and is both well-established and the source of outbreaks in areas of recent ZIKV introduction. DENV and ZIKV are closely related, resulting in substantial antigenic overlap. Through a mechanism known as antibody-dependent enhancement (ADE), anti-DENV antibodies can enhance the infectivity of DENV for certain classes of immune cells, causing increased viral production that correlates with severe disease outcomes. Similarly, ZIKV has been shown to undergo ADE in response to antibodies generated by other flaviviruses. However, response to DENV antibodies has not yet been investigated. Methodology / Principal Findings We tested the neutralizing and enhancing potential of well-characterized broadly neutralizing human anti-DENV monoclonal antibodies (HMAbs) and human DENV immune sera against ZIKV using neutralization and ADE assays. We show that anti-DENV HMAbs, cross-react, do not neutralize, and greatly enhance ZIKV infection in vitro. DENV immune sera had varying degrees of neutralization against ZIKV and similarly enhanced ZIKV infection. Conclusions / Significance Our results suggest that pre-existing DENV immunity will enhance ZIKV infection in vivo and may increase disease severity. A clear understanding of the interplay between ZIKV and DENV will be critical in informing public health responses in regions where these viruses co-circulate and will be particularly valuable for ZIKV and DENV vaccine design and implementation strategies.",BiorXiv,May 30, 2016,Yes,,No,"Zika, indirect evidence or other topic",Scientific (journal) article,No,Original research,No,Yes,1083,Basic and applied biomedical research,In vitro experiment
1084,"Lee, The Ewha Medical Journal, 2016",Lee,"Lee, Miae",Diagnosis for Imported Cases of Emerging and Reemerging Infectious Diseases in Korea,The Ewha Medical Journal,39,2,37,2016,2010-present,,20160376189,10.12771/emj.2016.39.2.37,2593,Other,http://emj.ewhamed.ac.kr/Synapse/Data/PDFData/0201EMJ/emj-39-37.pdf; http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emed14&AN=20160376189; http://lshtmsfx.hosted.exlibrisgroup.com/lshtm?sid=OVID:embase&id=pmid:&id=doi:10.12771%2Femj.2016.39.2.37&issn=2234-3180&isbn=&volume=39&issue=2&spage=37&pages=37-44&date=2016&title=EWHA+Medical+Journal&atitle=Diagnosis+for+Imported+Cases+of+Emerging+and+Reemerging+Infectious+Diseases+in+Korea&aulast=Lee&pid=%3Cauthor%3ELee+M.%3C%2Fauthor%3E%3CAN%3E20160376189%3C%2FAN%3E%3CDT%3EJournal%3A+Review%3C%2FDT%3E; http://synapse.koreamed.org/Synapse/Data/PDFData/0201EMJ/emj-39-37.pdf,"(Lee) Department of Laboratory Medicine, Ewha Womans University, School of Medicine, 1071 Anyangcheon-ro, Yangcheon-gu, Seoul 07985, South Korea; M. Lee, Department of Laboratory Medicine, Ewha Womans University, School of Medicine, 1071 Anyangcheon-ro, Yangcheon-gu, Seoul 07985, South Korea. E-mail: miae@ewha.ac.kr",,,,,Dengue; Diagnosis; Emerging infectious diseases; Middle east respiratory syndrome coronavirus; Zika virus; Coronavirus infection/di [Diagnosis]; dengue/di [Diagnosis]; epidemic; human; infection control; infection prevention; Korea; laboratory diagnosis; public health; review; zika fever/di [Diagnosis],"Despite recent advances in the development of diagnostics, therapeutics, and vaccines, the ease of international travel and increasing global interdependence have brought about particular challenges for the control of infectious diseases, highlighting concerns for the worldwide spread of emerging and reemerging infectious diseases. Korea is also facing public health challenges for controlling imported cases of infectious diseases; dengue virus, which is the most commonly reported case of imported infectious diseases; the largest outbreak of Middle East respiratory syndrome coronavirus infections outside the Arabian Peninsula in 2015; and the Zika virus infection, which was declared by the WHO as a 'Public Health Emergency of International Concern.' Although national and global partnerships are critical to controlling imported infectious disease threats, the role of local hospitals, public health sectors, and laboratory capacity remains the cornerstone for initial disease recognition and response. The current status of laboratory diagnosis for imported infectious diseases is reviewed.",Embase,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Unknown/unclear,Review,No,Yes,1084,Clinical/epidemiological research,Epidemiological/clinical review
1085,"Joob, Asian Pacific Journal of Tropical Disease, 2016",Joob,"Joob, B.; Wiwanitkit, V.",Diagnosis of Zika virus infection: Some important forgotten issues,Asian Pacific Journal of Tropical Disease,6,4,259,2016,2010-present,,20160332175,http://dx.doi.org/10.1016/S2222-1808%2815%2961026-X,2569,English,http://www.elsevier.com/wps/find/journaldescription.cws_home/726379/description#description; http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emed14&AN=20160332175; http://lshtmsfx.hosted.exlibrisgroup.com/lshtm?sid=OVID:embase&id=pmid:&id=doi:10.1016%2FS2222-1808%252815%252961026-X&issn=2222-1808&isbn=&volume=6&issue=4&spage=259&pages=259&date=2016&title=Asian+Pacific+Journal+of+Tropical+Disease&atitle=Diagnosis+of+Zika+virus+infection%3A+Some+important+forgotten+issues&aulast=Joob&pid=%3Cauthor%3EJoob+B.%3BWiwanitkit+V.%3C%2Fauthor%3E%3CAN%3E20160332175%3C%2FAN%3E%3CDT%3EJournal%3A+Letter%3C%2FDT%3E,"(Joob) Sanitation 1 Medical Academic Center, Bangkok, Thailand (Wiwanitkit) Hainan Medical University, Haikou, China (Wiwanitkit) Faculty of Medicine, University of Nis, Nis, Serbia (Wiwanitkit) Joseph Ayo Babalola University, Ikeji-Arakeji, Nigeria (Wiwanitkit) Dr. D.Y. Patil Medial University, Navi Mumbai, India; B. Joob, Sanitation 1 Medical Academic Center, Bangkok, Thailand. E-mail: beuyjoob@hotmail.com",,,,,clinical feature; dengue; diagnostic error; diagnostic test; false negative result; human; letter; polymerase chain reaction; priority journal; public health; thrombocytopenia; virus infection/di [Diagnosis]; Zika virus infection/di [Diagnosis],,Embase,May 30, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,1085,,
1086,"Naccache, bioRxiv, 2016",Naccache,"Naccache, Samia; Theze, Julien; Sardi, Silvia I.; Somasekar, Sneha; Greninger, Alexander L.; Bandeira, Antonio C.; Campos, Gubio S.; Tauro, Laura B.; Faria, Nuno R.; Pybus, Oliver G.; Chiu, Charles Y.","Discovery of a persistent Zika virus lineage in Bahia, Brazil",bioRxiv,,,49916,2016,2010-present,,,10.1101/049916,2174,English,http://biorxiv.org/content/early/2016/04/24/049916; files/1535/049916.html,,,,,,,"Metagenomic next-generation sequencing coupled with capture probe enrichment was used to recover 11 whole and partial Zika virus (ZIKV) genomes from patients in Bahia, Brazil from April 2015 to January 2016, where the majority of suspected Brazilian ZIKV cases have been reported. Phylogenetic reconstructions and molecular clock analyses using the newly generated data uncovered the existence of a Bahia-specific ZIKV lineage sharing a common ancestor in mid-2014, indicating sustained circulation of this strain in Bahia since that date.",BiorXiv,May 30, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,No,Original research,No,Yes,1086,Basic and applied biomedical research,Sequence analysis and phylogenetics
1087,"Ganguly, bioRxiv, 2016",Ganguly,"Ganguly, Bhaskar; Ganguly, Enakshi",Disruption of human astn2 function by ZIKV ns4b gene as a molecular basis for Zika viral microcephaly,bioRxiv,,,54486,2016,2010-present,,,10.1101/054486,2228,English,http://biorxiv.org/content/early/2016/05/20/054486,,India,Asia,India,,,"The present Zika virus (ZIKV) pandemic is being associated with increased incidence of microcephaly in newborns. However, a molecular basis for such pathogenesis is distinctly lacking. Comparative nucleic acid sequence analysis showed similarity between regions of non-structural protein 4B (ns4b) gene of ZIKV and human astrotactin2 (astn2) gene. Based on these findings, a molecular target of Zika viral microcephaly is being proposed.",BiorXiv,May 30, 2016,Yes,,Yes,,Scientific (journal) article,No,Original research,No,Yes,1087,Basic and applied biomedical research,Sequence analysis and phylogenetics
1088,"Dupont-Rouzeyrol, Lancet, 2016",Dupont-Rouzeyrol,"Dupont-Rouzeyrol, M.; Biron, A.; O. Connor O; Huguon, E.; Descloux, E.",Erratum: Infectious Zika viral particles in breastmilk (The Lancet (2016) 387 (1051)),Lancet,387,10023,1056,2016,2010-present,,20160233646,http://dx.doi.org/10.1016/S0140-6736%2816%2900663-2,2663,English,http://www.journals.elsevier.com/the-lancet/; http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emed13&AN=20160233646; http://lshtmsfx.hosted.exlibrisgroup.com/lshtm?sid=OVID:embase&id=pmid:&id=doi:10.1016%2FS0140-6736%252816%252900663-2&issn=0140-6736&isbn=&volume=387&issue=10023&spage=1056&pages=1056&date=2016&title=The+Lancet&atitle=Erratum%3A+Infectious+Zika+viral+particles+in+breastmilk+%28The+Lancet+%282016%29+387+%281051%29%29&aulast=Dupont-Rouzeyrol&pid=%3Cauthor%3EDupont-Rouzeyrol+M.%3BBiron+A.%3BOConnor+O.%3BHuguon+E.%3BDescloux+E.%3C%2Fauthor%3E%3CAN%3E20160233646%3C%2FAN%3E%3CDT%3EJournal%3A+Erratum%3C%2FDT%3E,,,,,,erratum; error,,Embase,May 30, 2016,No,Duplicate of existing record,,,,,,,,,,
1089,"Mouchtouri, Eurosurveillance, 2016",Mouchtouri,"Mouchtouri, V. A.; Hadjichristodoulou, C.",European Union SHIPSAN ACT Joint Action publishes interim guidance on maritime transport and Zika virus disease,Eurosurveillance,21,16,61-61,2016,2010-present,,,10.2807/1560-7917.Es.2016.21.16.30207,2192,English,<Go to ISI>://WOS:000374833800009,"Univ Thessaly, European Union SHIPSAN ACT Joint Action, Larisa, Greece; Univ Thessaly, Dept Hyg & Epidemiol, Larisa, Greece",,,,,,,Eurosurveillance,May 30, 2016,No,"Zika, not relevant to causality framework",,,News item or lay press,,,No,Yes,1089,,
1090,"Gunaratne, arXiv, 2016",Gunaratne,"Gunaratne, Chathika; Akbas, Mustafa Ilhan; Garibay, Ivan; Ozmen, Ozlem",Evaluation of Zika Vector Control Strategies Using Agent-Based Modeling,arXiv,,,,2016,2010-present,,,,2250,,https://arxiv.org/abs/1604.06121,,,,,,Computer Science - Multiagent Systems; Quantitative Biology - Populations and Evolution,"Aedes Aegypti is the vector of several deadly diseases, including Zika. Effective and sustainable vector control measures must be deployed to keep A. aegypti numbers under control. The distribution of A. Aegypti is subject to spatial and climatic constraints. Using agentbased modeling, we model the population dynamics of A. aegypti subjected to the spatial and climatic constraints of a neighborhood in the Key West. Satellite imagery was used to identify vegetation, houses(CO2 zones) both critical to the mosquito lifecycle. The model replicates the annual fluctuation of adult population sampled through field studies and approximates the population between 1 per 12m2 during summer and 1 per 59 m2 during winter. We then simulate two biological vector control strategies: 1) Release of Insects carrying a Dominant Lethal gene (RIDL) and 2) Wolbachia infection. Our results support the sustainability of Wolbachia infection within the population from the year of treatment onto the next. For the assessment of these two strategies, our approach provides a realistic simulation environment consisting of male and female Aedes aegypti, breeding spots, vegetation and CO2 sources.",ArXiv,May 30, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,No,Original research,No,Yes,1090,Environmental and vector research,Ecological/vector modelling
1091,"Ofula, International Journal of Infectious Diseases, 2016",Ofula,"Ofula, V. O.; Oundo, J.; Irura, Z.; Chepkorir, E.; Tigoi, C.; Ongus, J.; Coldren, R.; Sang, R.; Schoepp, R.; Rossi, C.","Evidence of presence of antibodies against selected arboviruses in Ijara and Marigat Districts, Kenya",International Journal of Infectious Diseases,45,,188-189,2016,2010-present,,72245391,10.1016/j.ijid.2016.02.438,2737,English,http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emed13&AN=72245391; http://lshtmsfx.hosted.exlibrisgroup.com/lshtm?sid=OVID:embase&id=pmid:&id=doi:10.1016%2Fj.ijid.2016.02.438&issn=1201-9712&isbn=&volume=45&issue=&spage=188&pages=188-189&date=2016&title=International+Journal+of+Infectious+Diseases&atitle=Evidence+of+presence+of+antibodies+against+selected+arboviruses+in+Ijara+and+Marigat+Districts%2C+Kenya&aulast=Ofula&pid=%3Cauthor%3EOfula+V.O.%3BOundo+J.%3BIrura+Z.%3BChepkorir+E.%3BTigoi+C.%3BOngus+J.%3BColdren+R.%3BSang+R.%3BSchoepp+R.%3BRossi+C.%3C%2Fauthor%3E%3CAN%3E72245391%3C%2FAN%3E%3CDT%3EJournal%3A+Conference+Abstract%3C%2FDT%3E; http://ac.els-cdn.com/S1201971216304179/1-s2.0-S1201971216304179-main.pdf?_tid=71d2203e-2672-11e6-8999-00000aacb35e&acdnat=1464618545_cb6e0171bae90999597c1e46979b2040,"(Ofula, Oundo) USAMRD-K, Nairobi, Kenya (Irura) Ministry of Public Helath and Sanitation, Nairobi, Kenya (Chepkorir) International Center for Insect Physiology and Ecology (ICIPE), Nairobi, Kenya (Tigoi, Sang) International Centre of Insect Physiology and Ecology, Nairobi, Kenya (Ongus) Jomo Kenyatta University of agriculture and technology, Nairobi, Kenya (Coldren) USAMRU-K, Nairobi, Kenya (Schoepp, Rossi) USAMRIID, Washington DC, United States; V.O. Ofula, USAMRD-K, Nairobi, Kenya",,,,,Arbovirus; Kenya; infection; human; Phlebotominae; virus; patient; population; female; hospital; Uganda; dengue; chikungunya; public health; tick; species; mosquito; arthropod; Anopheles; serodiagnosis; feeding; Culex; Alphavirus; Aedes; pyrexia idiopathica; blood; serum; industrialization; Flavivirus; West Nile virus; Semliki Forest virus; Sandfly fever Naples virus; enzyme linked immunosorbent assay; antibody; immunoglobulin G,"Background: Arboviruses are transmitted by arthropods with humans becoming infected during blood feeding by infected mosquitoes, ticks and sandflies. Characterization of arbovirus circulation and transmission in industrialized countries has been well documented, but there are many knowledge gaps in developing nations. Entomological surveys conducted so far have indicated circulation of arboviruses of significant public health importance in Aedes, Anopheles and Culex species in vast populations in Kenya, suggesting the presence of competent vector systems. Methods&Materials: The human involvement in the transmission cycle of these viruses has, however, not been demonstrated. This study sought to determine the circulation of a range of arboviruses including Chikungunya, Dengue, Sindbis, Sandfly Naples, Sandfly Sicilian, Uganda S, West Nile and Zika viruses in Ijara and Marigat Districts where vector surveillance has been done. Results: A total of 351 patient serum samples were analyzed for presence of antibodies using IgG ELISA. Of these, 190 (54.2%) were female and 161 (45.8%) were female, with ages ranging between 1 and 73. These were hospital based patients who presented to the hospital with fever of unknown origin. The overall arbovirus percentage circulation among these patients was 53/351 (15.1%) with 7% (10/143) in Marigat and 21% (43/208) in Ijara. Of the positives, flaviviruses were 69%, alpha viruses 29.6% and bunyaviruses 1.4%. Uganda S virus was the highest in circulation at 10%, followed by West Nile virus 6%, Sindbis 5%, Dengue 2%, Chikungunya 1.1%, Sandfly Naples 0.2% respectively. Semliki-forest virus-specific antibodies were detected by plaque reduction neutralization test in 3/351 (0.85%) persons tested. Antibodies against Sandfly Sicilian and Zika viruses were not detected. This study constitutes the first detection of antibodies against Sandfly Naples virus in Kenya. Conclusion: The study has demonstrated the presence of antibodies against selected arboviruses in the two sites amongst the human population. These findings will improve our understanding of the impact of arboviruses on public health in the region so that preventive actions and awareness among clinicians can be enhanced.",Embase,May 30, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Original research,No,Yes,1091,Clinical/epidemiological research,Cross-sectional study
1092,"Anonymous, Clinical Pharmacist, 2016",Anonymous,Anonymous,Evidence shows Zika virus crosses placental barrier,Clinical Pharmacist,8,3,,2016,2010-present,,20160332385,10.1211/cp.2016.20200747,2588,English,http://www.pharmaceutical-journal.com/news-and-analysis/research-briefing/evidence-shows-zika-virus-crosses-placental-barrier/20200747.article; http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emed14&AN=20160332385; http://lshtmsfx.hosted.exlibrisgroup.com/lshtm?sid=OVID:embase&id=pmid:&id=doi:10.1211%2FCP.2016.20200747&issn=1758-9061&isbn=&volume=8&issue=3&spage=no+pagination&pages=no+pagination&date=2016&title=Clinical+Pharmacist&atitle=Evidence+shows+Zika+virus+crosses+placental+barrier&aulast=&pid=%3Cauthor%3Eanonymous%3C%2Fauthor%3E%3CAN%3E20160332385%3C%2FAN%3E%3CDT%3EJournal%3A+Short+Survey%3C%2FDT%3E,,,,,,amnion fluid; blood placenta barrier; Brazil; cross infection; human; microcephaly; nonhuman; pregnant woman; short survey; Zika fever; zika virus,,Embase,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,1092,,
1093,"Arauz, Emerg Infect Dis, 2016",Arauz,"Arauz, D.; De Urriola, L.; Jones, J.; Castillo, M.; Martinez, A.; Murillo, E.; Troncoso, L.; Chen, M.; Abrego, L.; Armien, B.; Pascale, J. M.; Sosa, N.; Lopez-Verges, S.; Moreno, B.","Febrile or Exanthematous Illness Associated with Zika, Dengue, and Chikungunya Viruses, Panama",Emerg Infect Dis,22,8,,2016,2010-present,,27139219,10.3201/eid2208.160292,2198,,http://www.ncbi.nlm.nih.gov/pubmed/27139219,,,,,,Panama; Zika virus; chikungunya virus; dengue virus; exanthematous illness; febrile illness; flavivirus; outbreak; viruses,,EID,May 30, 2016,Yes,,No,"Zika, not relevant to causality framework",Scientific (journal) article,Unknown/unclear,Original research,No,Yes,1093,Clinical/epidemiological research,Case series
1094,"Serra Valdés, Rev. habanera cienc. méd, 2016",Serra Valdés,"Serra Valdés, Miguel Ángel",Fiebre por virus Zika: una alerta necesaria^ies; Zika virus fever: A necessary alert^ien,Rev. habanera cienc. méd,15,1,0-0,2016,2010-present,,,,2205,Spanish,http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1729-519X2016000100001,,,,,,,,LILACS,May 30, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,1094,,
1095,"Anonymous, Deutsche Apotheker Zeitung, 2016",Anonymous,Anonymous,Figures and facts on the zika virus: An apparently harmless infection leads to a global health state of emergency,Deutsche Apotheker Zeitung,156,5,,2016,2010-present,,20160228313,,2664,English,https://www.deutsche-apotheker-zeitung.de/daz-az/2016/daz-5-2016/adexa-tipp-teilzeit-tarifrechner; http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emed13&AN=20160228313; http://lshtmsfx.hosted.exlibrisgroup.com/lshtm?sid=OVID:embase&id=pmid:&id=doi:&issn=0011-9857&isbn=&volume=156&issue=5&spage=no+pagination&pages=no+pagination&date=2016&title=Deutsche+Apotheker+Zeitung&atitle=Zahlen+%26+Fakten+zum+Zika-Virus%3A+Eine+scheinbar+harmlose+Infektion+fuhrt+zu+globalem+Gesundheitsnotstand&aulast=&pid=%3Cauthor%3Eanonymous%3C%2Fauthor%3E%3CAN%3E20160228313%3C%2FAN%3E%3CDT%3EJournal%3A+Note%3C%2FDT%3E,,,,,,note; public health; virus infection; Zika virus infection,,Embase,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,1095,,
1096,"Favoretto, bioRxiv, 2016",Favoretto,"Favoretto, Silvana; Araujo, Danielle; Oliveira, Danielle; Duarte, Nayle; Mesquita, Flavio; Zanotto, Paolo; Durigon, Edison",First detection of Zika virus in neotropical primates in Brazil: a possible new reservoir,bioRxiv,,,49395,2016,2010-present,,,10.1101/049395,2202,English,http://biorxiv.org/content/early/2016/04/20/049395,,,,,,,Samples from sera and oral swabs from fifteen marmosets (Callithrix jacchus) and nine capuchin-monkeys (Sapajus libidinosus) captured in Ceara State in Brazil were tested for Zika virus. Samples were positive by Real time PCR and sequencing of the amplified product from a capuchin monkey showed 100% similarity to other ZIKV from South America. This is the first report on ZIKV detection among Neotropical primates.,BiorXiv,May 30, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,No,Original research,No,Yes,1096,Environmental and vector research,Ecological/animal cross-sectional
1097,"Solomon, International Journal of Infectious Diseases, 2016",Solomon,"Solomon, T.","Flavivirus encephalitis and other neurological syndromes (Japanese encephalitis, WNV, Tick borne encephalits, Dengue, Zika virus)",International Journal of Infectious Diseases,45,,24,2016,2010-present,,72245053,10.1016/j.ijid.2016.02.086,2723,English,http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emed13&AN=72245053; http://lshtmsfx.hosted.exlibrisgroup.com/lshtm?sid=OVID:embase&id=pmid:&id=doi:10.1016%2Fj.ijid.2016.02.086&issn=1201-9712&isbn=&volume=45&issue=&spage=24&pages=24&date=2016&title=International+Journal+of+Infectious+Diseases&atitle=Flavivirus+encephalitis+and+other+neurological+syndromes+%28Japanese+encephalitis%2C+WNV%2C+Tick+borne+encephalits%2C+Dengue%2C+Zika+virus%29&aulast=Solomon&pid=%3Cauthor%3ESolomon+T.%3C%2Fauthor%3E%3CAN%3E72245053%3C%2FAN%3E%3CDT%3EJournal%3A+Conference+Abstract%3C%2FDT%3E; http://ac.els-cdn.com/S1201971216300650/1-s2.0-S1201971216300650-main.pdf?_tid=79189922-2672-11e6-bc47-00000aacb362&acdnat=1464618558_7926cd98e7169b6ba13b4207334daab6,"(Solomon) University of Liverpool, Liverpool, United Kingdom; T. Solomon, University of Liverpool, Liverpool, United Kingdom",,,,,encephalitis; neurologic disease; Japanese encephalitis; tick; dengue; virus; infection; Flavivirus; human; Asia; natural host; mosquito; clinical feature; childhood; epidemiology; flaccid paralysis; poliomyelitis; disability; population; aged; tourism; diseases; Dengue virus; Japanese encephalitis virus; myelitis; Tick borne encephalitis virus; motor dysfunction; febrile convulsion; aseptic meningitis; West Nile virus; diagnosis; Western Hemisphere; virus infection; rash; Europe; patient; vaccination; South America; vaccine,"Flaviviruses are some of the most important causes of encephalitis, and other neurological syndromes globally, and have an ability to spread to new areas causing large outbreaks. Some are zoonotic, transmitted from animals to humans via mosquitoes (e.g. Japanese encephalitis virus - JEV, and West Nile virus - WNV) or ticks, (Tick-borne encephalitis virus - TBEV). For other flaviviruses humans are the natural hosts; these include dengue virus (DENV), and Zika virus (ZIKV). The clinical epidemiology of neurological disease caused by flaviviruses varies. JEV is numerically the most important cause of encephalitis with up to 70,000 cases annually across Asia. Almost all those living in rural Asia become infected during childhood, but only a small proportion develops neurological disease. Clinical features include a non-specific febrile illness, aseptic meningitis, febrile seizures, encephalitis, with Parkinsonian movement disorders, and myelitis, causing a poliomyelitis-like flaccid paralysis. There is no specific treatment, but good supportive care is essential. Recognition and control of JE has been improved in recent years through better surveillance, improved diagnostics, on disability and disease burden and greater use of vaccines. Being a mosquito-borne zoonotic Flavivirus, WNV is broadly similar to JEV. Its arrival and spread across the Americas in the last 15 years has taught us a great deal about the emergence of such viruses among populations of animals and humans that have not been exposed previously: disease tends to be seen in the elderly and sick. TBEV is seen in cooler parts of Asia and Europe where ticks predominate. Humans tend to become exposed to infected ticks in wooded areas through tourism or work. The disease is well controlled in countries with strong vaccination programmes. For dengue and Zika virus humans are the natural hosts, and so most patients present with a febrile syndrome, whichmayinclude a rash. However the neurological manifestations of dengue, including encephalitis, have been recognised increasingly over the last twenty years. The neurological associations of Zika virus infection are beginning to be recognised with the ongoing large outbreaks in South America.",Embase,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,No,Comment/Editorial/Perspective/Letter,No,Yes,1097,,
1098,"Goubert, bioRxiv, 2016",Goubert,"Goubert, Clement; Henri, Helene; Minard, Guillaume; Valiente Moro, Claire; Mavingui, Patrick; Vieira, Cristina; Boulesteix, Matthieu",High-Throughput Sequencing of Transposable Elements Insertions Provides Evidence for Adaptive Evolution of the Invasive Asian Tiger Mosquito Towards Temperate Environments,bioRxiv,,,49197,2016,2010-present,,,10.1101/049197,2188,English,http://biorxiv.org/content/early/2016/05/26/049197; files/1544/049197.html,,,,,,,"Invasive species represent unique opportunities to evaluate the role of local adaptation during colonization of new environments. Among these, the Asian tiger mosquito, Aedes albopictus, is a threatening vector of several human viral diseases, including dengue, chikungunya and the emerging Zika fevers. Its broad presence in both temperate and tropical environments has sometimes been considered as the reflect of a great 'ecological plasticity'. However, no study has been conducted to assess the role of adaptive evolution in the ecological success of Ae. albopictus at the molecular level. In the present study we performed a genomic scan to search for potential signatures of selection leading to local adaptation in a hundred of field collected mosquitoes from native populations of Vietnam and temperate invasive populations of Europe. High throughput genotyping of transposable element insertions generated more than 120 000 polymorphic loci, which in their great majority revealed a virtual absence of structure between bio-geographic areas. Nevertheless, 92 outlier loci show a high level of differentiation between temperate and tropical populations. The majority of these loci segregates at high insertion frequencies among European populations, indicating that this pattern could have been caused by recent events of adaptive evolution in temperate areas. Six outliers were located near putative diapause effector genes, suggesting fine tunning of this critical pathway during local adaptation.",BiorXiv,May 30, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,No,Original research,No,Yes,1098,Basic and applied biomedical research,Sequence analysis and phylogenetics
1099,"Doan, bioRxiv, 2016",Doan,"Doan, Thuy; Wilson, Michael R.; Crawford, Emily D.; Chow, Eric D.; Khan, Lillian M.; Knopp, Kristeene A.; Xia, Dongxiang; Hacker, Jill K.; Stewart, Jay M.; Gonzales, John A.; Acharya, Nisha R.; DeRisi, Joseph L.",Illuminating Uveitis: Metagenomic Deep Sequencing Identifies Common and Rare Pathogens,bioRxiv,,,54148,2016,2010-present,,,10.1101/054148,2249,English,http://biorxiv.org/content/early/2016/05/18/054148,,,,,,,"Background Ocular infections remain a major cause of blindness and morbidity worldwide. While prognosis is dependent on the timing and accuracy of diagnosis, the etiology remains elusive in approximately 50% of presumed infectious uveitis cases.1, 2 We aimed to determine if unbiased metagenomic deep sequencing (MDS) can accurately detect pathogens in intraocular fluid samples of patients with uveitis. Methods This is a proof-of-concept study, in which intraocular fluid samples were obtained from 5 subjects with known diagnoses, and one subject with bilateral chronic uveitis without a known etiology. Samples were subjected to MDS, and results were compared with conventional diagnostic tests. Pathogens were identified using a rapid computational pipeline to analyze the non-host sequences obtained from MDS. Findings Unbiased MDS of intraocular fluid produced results concordant with known diagnoses in subjects with (n=4) and without (n=1) uveitis. Rubella virus (RV) was identified in one case of chronic bilateral idiopathic uveitis. The subject's strain was most closely related to a German RV strain isolated in 1992, one year before he developed a fever and rash while living in Germany. Interpretation MDS can identify fungi, parasites, and DNA and RNA viruses in minute volumes of intraocular fluid samples. The identification of chronic intraocular RV infection highlights the eye's role as a long-term pathogen reservoir, which has implications for virus eradication and emerging global epidemics.",BiorXiv,May 30, 2016,No,Unrelated to Zika virus,,,Scientific (journal) article,No,Original research,No,Yes,1099,Basic and applied biomedical research,Sequence analysis and phylogenetics
1100,"Menon, International Journal of Infectious Diseases, 2016",Menon,"Menon, V. C.",India - National disaster and epidemic preparedness,International Journal of Infectious Diseases,45,,12,2016,2010-present,,72245029,10.1016/j.ijid.2016.02.059,2717,English,http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emed13&AN=72245029; http://lshtmsfx.hosted.exlibrisgroup.com/lshtm?sid=OVID:embase&id=pmid:&id=doi:10.1016%2Fj.ijid.2016.02.059&issn=1201-9712&isbn=&volume=45&issue=&spage=12&pages=12&date=2016&title=International+Journal+of+Infectious+Diseases&atitle=India+-+National+disaster+and+epidemic+preparedness&aulast=Menon&pid=%3Cauthor%3EMenon+V.C.%3C%2Fauthor%3E%3CAN%3E72245029%3C%2FAN%3E%3CDT%3EJournal%3A+Conference+Abstract%3C%2FDT%3E; http://ac.els-cdn.com/S1201971216300388/1-s2.0-S1201971216300388-main.pdf?_tid=7b4df08e-2672-11e6-855a-00000aab0f27&acdnat=1464618561_f6b9d2384dfd35710078dea91667b2bb,"(Menon) National Disaster Management Authority (NDMA), New Delhi, India; V.C. Menon, National Disaster Management Authority (NDMA), New Delhi, India",,,,,epidemic; infection; India; health; human; avian influenza; biological accident; swine influenza; Ebola hemorrhagic fever; virus; government; dengue; travel; emergency; public health; welfare; severe acute respiratory syndrome; weapon; Middle East; Ebolavirus; storage; Africa; health care personnel; hospital infection; patient; immune deficiency; plague; Human immunodeficiency virus; plant; gas; Spanish influenza; fallout; virus infection; infection control; architecture; contact examination; traffic and transport; case management; airport; aircraft; Aedes; mosquito; Brazil; Western Hemisphere; disease surveillance; monitoring; terrorism; biological product; cyanide,"History provides us several illustrations where epidemic outbreaks have led to biological disasters. Accidental or deliberate release of harmful micro-organisms can also lead to biological disasters. With the advent of bio-terrorism, there is a growing realisation that biological agents can also be used as weapons of mass destruction. The spread of Spanish Influenza of 1917-18, the Human Immunodeficiency Virus (HIV) / Acquired Immuno Deficiency Syndrome (AIDS), Severe Acute Respiratory Syndrome (SARS), Swine Flu (H1N1), Avian Influenza (H5N1), Middle East Respiratory Syndrome (MERS), dengue, chikunguniya, Ebola outbreak in West Africa and the recent Zika outbreak in several countries tested the capacities of the public health delivery system in several countries. In India, the spread of dengue, chikunguniya, swine flu, avian influenza in hitherto non-endemic regions in the past few years posed serious challenges to the health delivery architecture in the country. The fallout of the Methyl Iso Cyanide gas leak in the Union Carbide Plant in Bhopal in 1984, alleged plague outbreaks in Beed and Surat in 1994, the avian influenza outbreak in 2012 and 2013, swine flu in India in 2014 and 2015 have also been major challenges to the public health delivery systems in the affected areas. The National Disaster Management Authority (NDMA), Government of India released the 'National Disaster Management Guidelines on the Management of Biological Disasters' in July 2008. The Ministry of Health and Family Welfare also disseminated the Guidelines on Ebola like Guidelines for Safe Handling of Human Remains of Ebola Patients, Hospital Infection Control Guidelines, Ebola Virus Fact Sheet, Guidelines on Contact Tracing and Management of Contact, Guidelines for Sample Collection, Storage and Transportation, Guidelines for Clinical case Management, Guidelines for healthcare providers, Advisory for Travellers visiting Countries Affected with EVD, Advisory for Families Staying and Travellers Visiting Countries Affected with EVD, Advisory for Airlines on EVD, Health Alert on EVD for Display at Airports etc. In the aftermath of the spread of Zika virus, the Ministry of Health and Family Welfare, Government of India also released on 2nd February 2016 'Guidelines for Integrated Vector Management for Control of Aedes Mosquito' and 'Guidelines on Zika Virus Disease following Epidemic in Brazil and other countries of America' to strengthen preparedness and emergency response capacities in the event of any reported case of Zika virus in India. The presentation provides an overview of issues related to the management of epidemics in India, including a critique on the levels of preparedness, emergency response capacities and the need for strengthening disease surveillance and monitoring of early warning signals.",Embase,May 30, 2016,No,Unrelated to Zika virus,,,Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,1100,,
1101,", MMWR Morb Mortal Wkly Rep, 2016",,,"Interim Guidance for Zika Virus Testing of Urine - United States, 2016",MMWR Morb Mortal Wkly Rep,65,18,474,2016,2010-present,,27171368,10.15585/mmwr.mm6518e1,2169,,http://www.ncbi.nlm.nih.gov/pubmed/27171368,,,,,,,"Diagnostic testing for Zika virus infection can be accomplished using molecular and serologic methods. Real-time reverse transcription-polymerase chain reaction (rRT-PCR) is the preferred test for Zika virus infection because it can be performed rapidly and is highly specific (1,2). However, in most patients, Zika virus RNA is unlikely to be detected in serum after the first week of illness (2,3). Recent reports using adaptations of previously published methods (2,4) suggest that Zika virus RNA can be detected in urine for at least 2 weeks after onset of symptoms (3,5-7). Currently, the CDC Trioplex rRT-PCR assay is the only diagnostic tool authorized by the Food and Drug Administration for Zika virus testing of urine (1). Other laboratory-developed tests will need in-house validations to adequately characterize the performance of the assay and meet Clinical Laboratory Improvement Amendments requirements. Further investigation is needed to determine the sensitivity and utility of Zika virus rRT-PCR on urine specimens collected >/=14 days after onset of symptoms.",CDC,May 30, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,No,Original research,No,Yes,1101,Clinical/epidemiological research,Guidelines
1102,"Calda, Aktualni Gynekologie a Porodnictvi, 2016",Calda,"Calda, P.","Is the Zika virus a real threat to pregnant women, or is this perception unwarranted and based on coincidence?",Aktualni Gynekologie a Porodnictvi,8,,13-17,2016,2010-present,,20160316877,,2603,English,http://www.actualgyn.com/; http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emed14&AN=20160316877; http://lshtmsfx.hosted.exlibrisgroup.com/lshtm?sid=OVID:embase&id=pmid:&id=doi:&issn=1803-9588&isbn=&volume=8&issue=&spage=13&pages=13-17&date=2016&title=Aktualni+Gynekologie+a+Porodnictvi&atitle=Is+the+Zika+virus+a+real+threat+to+pregnant+women%2C+or+is+this+perception+unwarranted+and+based+on+coincidence%3F&aulast=Calda&pid=%3Cauthor%3ECalda+P.%3C%2Fauthor%3E%3CAN%3E20160316877%3C%2FAN%3E%3CDT%3EJournal%3A+Article%3C%2FDT%3E,"(Calda) Department of Obstetrics and Gynecology, 1st Medical Faculty, Charles University, Prague, Apolinarska 18, Praha 2 128 51, Czech Republic; P. Calda, Department of Obstetrics and Gynecology, 1st Medical Faculty, Charles University, Prague, Apolinarska 18, Praha 2 128 51, Czech Republic. E-mail: pavel.calda@vfn.cz",,,,,Microcephaly; Prenatal diagnosis; Ultrasound; Vertical transmission; Zika virus; article; female; fetus malformation; human; life threat; nonhuman; pregnant woman; zika fever,"In 2015 a sudden increase in the number of cases of microcephaly was reported in Brazil. At present, many sources suggest a connection between these cases and infection with the Zika virus. Although there have been several published case reports in which the Zika virus was found in affected women and their fetuses and newborns, the methodology used in diagnosis of many such cases is in doubt. The causal link between Zika infection and fetal anomaly has not been definitely, or even convincingly, demonstrated to date. The global campaign, aimed at improving the diagnosis, prevention, and possible treatment of Zika infection, was initiated on insubstantial evidence. Well-designed studies, rather than just case reports, will be necessary to confirm and demonstrate the actual link between maternal infection and fetal anomaly. Likewise, the exact risk of vertical transmission and its fetal effects must be conclusively demonstrated. That there is a threat posed to the fetus by maternal Zika infection is certainly a possibility, but while there is so little real evidence, coincidence or unjustified haste in jumping to conclusions might equally be at work.",Embase,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,1102,,
1103,"Rizo-Gil, Rev. Fac. Nac. Salud Pública, 2016",Rizo-Gil,"Rizo-Gil, Alberto",La epidemia del zika beneficia a la salud materna?^ies; Does epidemic zika benefit maternal health?^ien; Benefícios para a saúde materna epidemia Zika?^ipt,Rev. Fac. Nac. Salud Pública,34,1,96-104,2016,2010-present,,,,2258,,http://www.scielo.org.co/scielo.php?script=sci_arttext&pid=S0120-386X2016000100014,,,,,,,,LILACS,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,1103,,
1104,"Van Esbroeck, Eurosurveillance, 2016",Van Esbroeck,"Van Esbroeck, M.; Meersman, K.; Michiels, J.; Arien, K. K.; Van den Bossche, D.",Letter to the editor: Specificity of Zika virus ELISA: interference with malaria,Eurosurveillance,21,21,,2016,2010-present,,27254259,10.2807/1560-7917.ES.2016.21.21.30237,2226,,http://www.ncbi.nlm.nih.gov/pubmed/27254259,"National Reference Center for Arboviruses, Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.",,,,,Elisa; Zika virus; malaria; specificity,,Eurosurveillance,May 30, 2016,Yes,,No,"Zika, not relevant to causality framework",Scientific (journal) article,Unknown/unclear,Original research,No,Yes,1104,Clinical/epidemiological research,Diagnostic study
1105,"Rodriguez-Morales, F1000Res, 2016",Rodriguez-Morales,"Rodriguez-Morales, A. J.; Galindo-Marquez, M. L.; Garcia-Loaiza, C. J.; Sabogal-Roman, J. A.; Marin-Loaiza, S.; Ayala, A. F.; Lozada-Riascos, C. O.; Sarmiento-Ospina, A.; Vasquez-Serna, H.; Jimenez-Canizales, C. E.; Escalera-Antezana, J. P.","Mapping Zika virus infection using geographical information systems in Tolima, Colombia, 2015-2016",F1000Res,5,,568,2016,2010-present,,27134732,10.12688/f1000research.8436.1,2542,English,http://www.ncbi.nlm.nih.gov/pubmed/27134732,"Public Health and Infection Research Group, Universidad Tecnologica de Pereira, Pereira, Colombia; Organizacion Latinoamericana para el Fomento de la Investigacion en Salud (OLFIS), Riohacha, Colombia; Colombian Collaborative Network of Zika (RECOLZIKA), Pereira, Colombia.; Public Health and Infection Research Group, Universidad Tecnologica de Pereira, Pereira, Colombia.; Regional Information System, Universidad Tecnologica de Pereira, Pereira, Colombia.; Colombian Collaborative Network of Zika (RECOLZIKA), Pereira, Colombia; Secretary of Health of Ibague, Ibague, Colombia.; Colombian Collaborative Network of Zika (RECOLZIKA), Pereira, Colombia; Secretary of Health of Tolima, Ibague, Colombia.; Public Health and Infection Research Group, Universidad Tecnologica de Pereira, Pereira, Colombia; Colombian Collaborative Network of Zika (RECOLZIKA), Pereira, Colombia; Secretary of Health of Tolima, Ibague, Colombia.; Colombian Collaborative Network of Zika (RECOLZIKA), Pereira, Colombia; Tongji Hospital - Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.",,,,,Colombia; Latin America.; Zika; epidemiology; public health; travelers,"OBJECTIVE: Geographical information systems (GIS) have been extensively used for the development of epidemiological maps of tropical diseases, however not yet specifically for Zika virus (ZIKV) infection. METHODS: Surveillance case data of the ongoing epidemics of ZIKV in the Tolima department, Colombia (2015-2016) were used to estimate cumulative incidence rates (cases/100,000 pop.) to develop the first maps in the department and its municipalities, including detail for the capital, Ibague. The GIS software used was Kosmo Desktop 3.0RC1(R). Two thematic maps were developed according to municipality and communes incidence rates. RESULTS: Up to March 5, 2016, 4,094 cases of ZIKV were reported in Tolima, for cumulated rates of 289.9 cases/100,000 pop. (7.95% of the country). Burden of ZIKV infection has been concentrated in its east area, where municipalities have reported >500 cases/100,000 pop. These municipalities are bordered by two other departments, Cundinamarca (3,778 cases) and Huila (5,338 cases), which also have high incidences of ZIKV infection. Seven municipalities of Tolima ranged from 250-499.99 cases/100,000 pop., of this group five border with high incidence municipalities (>250), including the capital, where almost half of the reported cases of ZIKV in Tolima are concentrated. CONCLUSIONS: Use of GIS-based epidemiological maps helps to guide decisions for the prevention and control of diseases that represent significant issues in the region and the country, but also in emerging conditions such as ZIKV.",Pubmed,May 30, 2016,No,Duplicate of existing record,,,,,,,,,,
1106,"Pustiglione, Rev. bras. med. trab, 2016",Pustiglione,"Pustiglione, Marcelo","Medicina do Trabalho e doenças emergentes, reemergentes e negligenciadas: a conduta no caso das febres da dengue, do Chikungunya e do Zika vírus^ipt; Occupational Medicine and emerging, reemerging and neglected diseases: the conduct in the case of dengue, Chikungunya and Zika virus^ien",Rev. bras. med. trab,14,1,,2016,2010-present,,,,2176,,http://files.bvs.br/upload/S/1679-4435/2016/v14n1/a5448.pdf,,,,,,,"Contexto: Doenças epidêmicas vetoriais emergentes, como as febres do Chikungunya (CHIKV) e do Zika vírus (ZIKAV), e reemergentes e/ou negligenciadas, como a febre da Dengue (sorotipos DENV-1, DENV-2, DENV-3 e DENV-4), têm sido objeto de muita preocupação da população e das autoridades sanitárias no Brasil, particularmente nos últimos cinco anos. A Medicina do Trabalho, como um dos braços da Saúde Pública e da Medicina Preventiva, tem papel importante nas ações de vigilância, prevenção e controle das doenças ocupacionais ou não, incluindo as coletivas epidêmicas transmitidas por vetores, como é o caso. Objetivo: Fazer uma breve atualização dessas doenças infecciosas e apontar as ações do Serviços Especializados em Engenharia de Segurança e em Medicina do Trabalho (SESMT), contextualizando-as de acordo com as peculiaridades das doenças estudadas. Método: Para a realização deste estudo foi feita revisão da literatura e dos boletins oficiais referentes aos casos dessas viroses no Brasil nos últimos dois anos. Resultados: São apresentados perfis e quadros comparativos enfocando as características e diferenciais de cada uma das três doenças estudadas. Conclusão: A Medicina do Trabalho como ramo da Saúde Pública tem um papel preponderante no controle das doenças infecciosas, estejam elas relacionadas ou não com a atividade laboral do grupo de trabalhadores-alvo.(AU)^ipt; Introduction: Emerging vector epidemic diseases such as fever Chikungunya (CHIKV) and Zika virus (ZIKAV), and reemerging and/or neglected ones, such as the Dengue fever (DENV-1 serotypes DENV-2, DENV-3 and DENV-4 ) have been the subject of much concern in the population and health authorities in Brazil, particularly in the last five years. The Occupational Medicine, as one arm of the Public Health and Preventive Medicine, has an important role in surveillance, prevention and control of diseases, occupational or not, including collective epidemic transmitted by vectors, as is the case. Objective: To make a brief update of these infectious diseases and to point the actions of Occupational Medicine Services, contextualizing them according to the peculiarities of these diseases. Methods: Literature and official reports concerning cases of these viruses in Brazil in the last two years were reviewed. Results: Profiles and comparative tables focusing on the features and advantages of each one of the three conditions studied are shown. Conclusion: The Occupational Medicine as a branch of Public Health has a major role in the control of infectious diseases whether they are related or not with the labor activity of the target group workers.(AU)^ien",LILACS,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Unknown/unclear,Review,No,Yes,1106,Clinical/epidemiological research,Epidemiological/clinical review
1107,"Carissimo, bioRxiv, 2016",Carissimo,"Carissimo, Guillaume; van den Beek, Marius; Pegoraro, Juliana; Vernick, Kenneth D.; Antoniewski, Christophe","Metavisitor, a suite of Galaxy tools for simple and rapid detection and discovery of viruses in deep sequence data",bioRxiv,,,48983,2016,2010-present,,,10.1101/048983,2262,English,http://biorxiv.org/content/early/2016/05/20/048983; files/1547/048983.html,,,,,,,"We present user-friendly and adaptable software to provide biologists, clinical researchers and possibly diagnostic clinicians with the ability to robustly detect and reconstruct viral genomes from complex deep sequence datasets. A set of modular bioinformatic tools and workflows was implemented as the Metavisitor package in the Galaxy framework. Using the graphical Galaxy workflow editor, users with minimal computational skills can use existing Metavisitor workflows or adapt them to suit specific needs by adding or modifying analysis modules. Metavisitor can be used on our Mississippi server, or can be installed on any Galaxy server instance and a pre-configured Metavisitor server image is provided. Metavisitor works with DNA, RNA or small RNA sequencing data over a range of read lengths and can use a combination of de novo and guided approaches to assemble genomes from sequencing reads. We show that the software has the potential for quick diagnosis as well as discovery of viruses from a vast array of organisms. Importantly, we provide here executable Metavisitor use cases, which increase the accessibility and transparency of the software, ultimately enabling biologists or clinicians to focus on biological or medical questions.",BiorXiv,May 30, 2016,No,Unrelated to Zika virus,,,Scientific (journal) article,No,Original research,No,Yes,1107,Other,
1108,"Lotufo, Diagn. tratamento, 2016",Lotufo,"Lotufo, Paulo","Microcefalia, zika vírus e a soberania da observação clínica^ipt",Diagn. tratamento,21,1,,2016,2010-present,,,,2191,Portuguese,http://files.bvs.br/upload/S/1413-9979/2016/v21n1/a5411.pdf,,,,,,,,LILACS,May 30, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,1108,,
1109,"Triunfol, Lancet Infectious Diseases, 2016",Triunfol,"Triunfol, M.",Microcephaly in Brazil: confidence builds in Zika connection,Lancet Infectious Diseases,16,5,527-528,2016,2010-present,,,10.1056/NEJMoa1602412,2751,English,http://www.thelancet.com/journals/laninf/article/PIIS1473-3099(16)30015-9/abstract,,,,,,,,Lancet,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,News item or lay press,,,No,Yes,1109,,
1110,"Granato, Int J Gynaecol Obstet, 2016",Granato,"Granato, C.; Lazari, C.; Serafini, P. C.",New threat on the horizon: The Zika virus,Int J Gynaecol Obstet,133,2,137-8,2016,2010-present,,27058990,10.1016/j.ijgo.2016.03.006,2659,English,http://www.ncbi.nlm.nih.gov/pubmed/27058990,"Discipline of Infectious Disease, Sao Paulo Federal University, Sao Paulo, Brazil; Fleury Medical Group, Sao Paulo, Brazil.; Fleury Medical Group, Sao Paulo, Brazil; Department of Infectious Diseases, Faculty of Medicine, University of Sao Paulo, Sao Paulo, Brazil.; Department of Obstetrics and Gynecology, Discipline of Gynecology, University of Sao Paulo, Sao Paulo, Brazil; Reproductive Endocrinology, Huntington Reproductive Medicine, Sao Paulo, Brazil; Human Reproductive Service, University of Sao Paulo, Sao Paulo, Brazil. Electronic address: pauloivf@aol.com.",,,,,arthrogryposis; arthropathy; article; Chikungunya virus; conjunctivitis; household; human; hydrocephalus; microcephaly; mosquito; nonhuman; pregnant woman; priority journal; real time polymerase chain reaction; sexual transmission; virus infection; Zika fever; zika virus; immunoglobulin M antibody; yellow fever vaccine,,Embase,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,1110,,
1111,"Manrique, arXiv, 2016",Manrique,"Manrique, Pedro D.; Xu, Chen; Hui, Pak Ming; Johnson, Neil F.",Novel viral dynamics from transport through popular places,arXiv,,,,2016,2010-present,,,,2195,,http://arxiv.org/abs/1604.07637,,,,,,Condensed Matter - Statistical Mechanics; Physics - Physics and Society; Quantitative Biology - Populations and Evolution,"The flux of visitors through popular places undoubtedly influences viral spreading, from H1N1 and Zika viruses spreading through physical spaces such as airports, to rumors and idea spreading though online spaces such as chat-rooms and social media. However there is a lack of understanding of the types of viral dynamics that can result. Here we present a minimal dynamical model which focuses on the time-dependent interplay between the mobility through and the occupancy of such spaces. Our generic model permits analytic analysis while producing a rich diversity of infection profiles in terms of their shapes, duration, and intensities. The general features of these theoretical profiles compares well to real-world data of recent social contagion phenomena.",ArXiv,May 30, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,No,Original research,No,Yes,1111,Clinical/epidemiological research,Modelling study
1112,"InVS, Point Epidemiologique CIRE Antilles Guyane, 2016",InVS,InVS,Point epidemio: Emergence du virus zika aux Antilles Guyane : Situation epidemiologique - 21 avril 2016,Point Epidemiologique CIRE Antilles Guyane,15,,,2016,2010-present,,,,2244,French,,,France,Europe,,Public/Government,,,Institute de veille sanitaire,May 30, 2016,Yes,,No,"Zika, indirect evidence or other topic",Surveillance report or data,,,No,Yes,1112,Clinical/epidemiological research,Ecological study/outbreak report
1113,"Simeone, MMWR Morb Mortal Wkly Rep, 2016",Simeone,"Simeone, R. M.; Shapiro-Mendoza, C. K.; Meaney-Delman, D.; Petersen, E. E.; Galang, R. R.; Oduyebo, T.; Rivera-Garcia, B.; Valencia-Prado, M.; Newsome, K. B.; Perez-Padilla, J.; Williams, T. R.; Biggerstaff, M.; Jamieson, D. J.; Honein, M. A.; Zika,; Pregnancy Working, Group; Ahmed, F.; Anesi, S.; Arnold, K. E.; Barradas, D.; Barter, D.; Bertolli, J.; Bingham, A. M.; Bollock, J.; Bosse, T.; Bradley, K. K.; Brady, D.; Brown, C. M.; Bryan, K.; Buchanan, V.; Bullard, P. D.; Carrigan, A.; Clouse, M.; Cook, S.; Cooper, M.; Davidson, S.; DeBarr, A.; Dobbs, T.; Dunams, T.; Eason, J.; Eckert, A.; Eggers, P.; Ellington, S. R.; Feldpausch, A.; Fredette, C. R.; Gabel, J.; Glover, M.; Gosciminski, M.; Gay, M.; Haddock, R.; Hand, S.; Hardy, J.; Hartel, M. E.; Hennenfent, A. K.; Hills, S. L.; House, J.; Igbinosa, I.; Im, L.; Jeff, H.; Khan, S.; Kightlinger, L.; Ko, J. Y.; Koirala, S.; Korhonen, L.; Krishnasamy, V.; Kurkjian, K.; Lampe, M.; Larson, S.; Lee, E. H.; Lind, L.; Lindquist, S.; Long, J.; Macdonald, J.; MacFarquhar, J.; Mackie, D. P.; Mark-Carew, M.; Martin, B.; Martinez-Quinones, A.; Matthews-Greer, J.; McGee, S. A.; McLaughlin, J.; Mock, V.; Muna, E.; Oltean, H.; O'Mallan, J.; Pagano, H. P.; Park, S. Y.; Peterson, D.; Polen, K. N.; Porse, C. C.; Rao, C. Y.; Ropri, A.; Rinsky, J.; Robinson, S.; Rosinger, A. Y.; Ruberto, I.; Schiffman, E.; Scott-Waldron, C.; Semple, S.; Sharp, T.; Short, K.; Signs, K.; Slavinski, S. A.; Stevens, T.; Sweatlock, J.; Talbot, E. A.; Tonzel, J.; Traxler, R.; Tubach, S.; Van Houten, C.; VinHatton, E.; Viray, M.; Virginie, D.; Warren, M. D.; Waters, C.; White, P.; Williams, T.; Winters, A. I.; Wood, S.; Zaganjor, I.","Possible Zika Virus Infection Among Pregnant Women - United States and Territories, May 2016",MMWR Morb Mortal Wkly Rep,65,20,514-9,2016,2010-present,,27248295,10.15585/mmwr.mm6520e1,2252,,http://www.ncbi.nlm.nih.gov/pubmed/27248295,,,,,,,"Zika virus is a cause of microcephaly and brain abnormalities (1), and it is the first known mosquito-borne infection to cause congenital anomalies in humans. The establishment of a comprehensive surveillance system to monitor pregnant women with Zika virus infection will provide data to further elucidate the full range of potential outcomes for fetuses and infants of mothers with asymptomatic and symptomatic Zika virus infection during pregnancy. In February 2016, Zika virus disease and congenital Zika virus infections became nationally notifiable conditions in the United States (2). Cases in pregnant women with laboratory evidence of Zika virus infection who have either 1) symptomatic infection or 2) asymptomatic infection with diagnosed complications of pregnancy can be reported as cases of Zika virus disease to ArboNET* (2), CDC's national arboviral diseases surveillance system. Under existing interim guidelines from the Council for State and Territorial Epidemiologists (CSTE), asymptomatic Zika virus infections in pregnant women who do not have known pregnancy complications are not reportable. ArboNET does not currently include pregnancy surveillance information (e.g., gestational age or pregnancy exposures) or pregnancy outcomes. To understand the full impact of infection on the fetus and neonate, other systems are needed for reporting and active monitoring of pregnant women with laboratory evidence of possible Zika virus infection during pregnancy. Thus, in collaboration with state, local, tribal, and territorial health departments, CDC established two surveillance systems to monitor pregnancies and congenital outcomes among women with laboratory evidence of Zika virus infection(dagger) in the United States and territories: 1) the U.S. Zika Pregnancy Registry (USZPR),( section sign) which monitors pregnant women residing in U.S. states and all U.S. territories except Puerto Rico, and 2) the Zika Active Pregnancy Surveillance System (ZAPSS), which monitors pregnant women residing in Puerto Rico. As of May 12, 2016, the surveillance systems were monitoring 157 and 122 pregnant women with laboratory evidence of possible Zika virus infection from participating U.S. states and territories, respectively. Tracking and monitoring clinical presentation of Zika virus infection, all prenatal testing, and adverse consequences of Zika virus infection during pregnancy are critical to better characterize the risk for congenital infection, the performance of prenatal diagnostic testing, and the spectrum of adverse congenital outcomes. These data will improve clinical guidance, inform counseling messages for pregnant women, and facilitate planning for clinical and public health services for affected families.",CDC,May 30, 2016,Yes,,No,"Zika, not relevant to causality framework",Scientific (journal) article,No,Original research,No,Yes,1113,Clinical/epidemiological research,Ecological study/outbreak report
1114,"Martinez-Bakker, PeerJ Preprints, 2016",Martinez-Bakker,"Martinez-Bakker, Micaela E",Preventing Zika virus infection during pregnancy by timing conception seasonally,PeerJ Preprints,,,,2016,2010-present,,,https://doi.org/10.7287/peerj.preprints.1818v3,2677,,https://peerj.com/preprints/1818/,,,,,,,,PeerJ Preprints,May 30, 2016,Yes,,No,"Zika, not relevant to causality framework",Scientific (journal) article,No,Original research,No,Yes,1114,Clinical/epidemiological research,Modelling study
1115,"Gao, arXiv, 2016",Gao,"Gao, Daozhou; Lou, Yijun; He, Daihai; Porco, Travis C.; Kuang, Yang; Chowell, Gerardo; Ruan, Shigui",Prevention and control of Zika fever as a mosquito-borne and sexually transmitted disease,arXiv,,,,2016,2010-present,,,,2186,,http://arxiv.org/abs/1604.04008,,,,,,Quantitative Biology - Populations and Evolution,"The ongoing Zika virus (ZIKV) epidemic poses a major global public health emergency. It is known that ZIKV is spread by \textit{Aedes} mosquitoes, recent studies show that ZIKV can also be transmitted via sexual contact and cases of sexually transmitted ZIKV have been confirmed in the U.S., France, and Italy. How sexual transmission affects the spread and control of ZIKV infection is not well-understood. We presented a mathematical model to investigate the impact of mosquito-borne and sexual transmission on spread and control of ZIKV and used the model to fit the ZIKV data in Brazil, Colombia, and El Salvador. Based on the estimated parameter values, we calculated the median and confidence interval of the basic reproduction number R0=2.055 (95% CI: 0.523-6.300), in which the distribution of the percentage of contribution by sexual transmission is 3.044 (95% CI: 0.123-45.73). Our study indicates that R0 is most sensitive to the biting rate and mortality rate of mosquitoes while sexual transmission increases the risk of infection and epidemic size and prolongs the outbreak. In order to prevent and control the transmission of ZIKV, it must be treated as not only a mosquito-borne disease but also a sexually transmitted disease.",ArXiv,May 30, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,No,Original research,No,Yes,1115,Clinical/epidemiological research,Modelling study
1116,"ECDC, , 2016",ECDC,ECDC,Rapid risk assessment. Zika virus disease epidemic: potential association with microcephaly and Guillain-Barré syndrome. Fifth update 11 April 2016,,,,,2016,2010-present,,,,2172,,http://ecdc.europa.eu/en/publications/Publications/zika-virus-rapid-risk-assessment-11-april-2016.docx.pdf,,Sweden,Europe,,Public/Government,,,ECDC,May 30, 2016,Yes,,No,"Zika, indirect evidence or other topic",Surveillance report or data,,,No,Yes,1116,Clinical/epidemiological research,Ecological study/outbreak report
1117,"ECDC, , 2016",ECDC,ECDC,Rapid risk assessment. Zika virus disease epidemic: potential association with microcephaly and Guillain-Barré syndrome. Sixth update 20 May 2016,,,,,2016,2010-present,,,,2236,,http://ecdc.europa.eu/en/publications/Publications/zika%20virus%20rapid%20risk%20assessment%2010-05-2016.pdf,,Sweden,Europe,,Public/Government,,,ECDC,May 30, 2016,Yes,,No,"Zika, indirect evidence or other topic",Surveillance report or data,,,No,Yes,1117,Clinical/epidemiological research,Ecological study/outbreak report
1118,"Harachand, Contract Pharma, 2016",Harachand,"Harachand, S.",Seeking zika vax,Contract Pharma,,pagination,,2016,2010-present,,20160238667,,2649,English,http://www.contractpharma.com/issues/2016-03-01/view_india-report/seeking-zika-vac/; http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emed13&AN=20160238667; http://lshtmsfx.hosted.exlibrisgroup.com/lshtm?sid=OVID:embase&id=pmid:&id=doi:&issn=1544-3469&isbn=&volume=&issue=3&spage=no+pagination&pages=no+pagination&date=2016&title=Contract+Pharma&atitle=Seeking+zika+vax&aulast=Harachand&pid=%3Cauthor%3EHarachand+S.%3C%2Fauthor%3E%3CAN%3E20160238667%3C%2FAN%3E%3CDT%3ETrade+Journal%3A+Article%3C%2FDT%3E,"(Harachand) MumbaiIndia; S. Harachand, MumbaiIndia. E-mail: harachand@gmail.com",,,,,article; chikungunya; congenital malformation; dengue; drug approval; drug marketing; epidemic; government; human; India; national health organization; nonhuman; public health problem; South and Central America; vaccine production; virus infection/pc [Prevention]; virus infection/dt [Drug Therapy]; virus transmission; world health organization; Zika virus infection/pc [Prevention]; Zika virus infection/dt [Drug Therapy]; Ebola vaccine; Pneumococcus vaccine; unclassified drug; virus vaccine/dt [Drug Therapy]; virus vaccine/pr [Pharmaceutics]; Zika virus vaccine/dt [Drug Therapy]; Zika virus vaccine/pr [Pharmaceutics],,Embase,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,News item or lay press,,,No,Yes,1118,,
1119,"Lover, bioRxiv, 2016",Lover,"Lover, Andrew A.","Serological evidence for localized and persistent antibody response in Zika virus-positive neonates with microcephaly (Brazil, 2015)- a secondary analysis",bioRxiv,,,51326,2016,2010-present,,,10.1101/051326,2181,English,http://biorxiv.org/content/early/2016/05/17/051326; files/1505/051326.html,,United States,Americas,,,,"A recent publication in The Lancet by Cordeiro and colleagues reported levels of IgM for Zika (ZIKV) and dengue (DENV) viruses in serum and cerebrospinal fluid (CSF) of 31 infants born with microcephaly in Brazil. [The Lancet. 2016;387(10030):1811-1812. doi:10.1016/S0140-6736(16)30253-7.] Their study suggests higher titers in CSF relative to serum in individual neonates, but no quantitative comparisons are reported. In this short report, the differences in antibody titers are quantified and compared between sample sources; across sampling periods; and between sample sources within individual neonates to more comprehensively understand these data to inform serological surveillance. These are statistically significant differences in ZIKV titers between CSF and serum samples, (in contrast to DENV titers), and these ZIKV titer levels remain elevated across sampling dates, whereas the titer in serum trends downward by sampling date. In multivariate models, ZIKV titer in CSF samples is independent of titer in serum, and of DENV antibodies in both CSF and serum. These findings quantify the compartmentalization of ZIKV antigens across the blood-brain barrier, and suggest complex interplay between ZIKV and cross-reacting DENV antigens in congenital/neonatal infections.",BiorXiv,May 30, 2016,Yes,,No,"Zika, indirect evidence or other topic",Scientific (journal) article,No,Original research,Yes,No,758,Clinical/epidemiological research,Case series
1120,"Coelho, bioRxiv, 2016",Coelho,"Coelho, Flávio Codeço; Durovni, Betina; Saraceni, Valeria; Lemos, Cristina; Codeço, Claudia Torres; Camargo, Sabrina; Carvalho, Luiz Max; Bastos, Leonardo; Arduini, Denise; Villela, Daniel; Armstrong, Margaret","Sexual transmission causes a marked increase in the incidence of Zika in women in Rio de Janeiro, Brazil",bioRxiv,,,55459,2016,2010-present,,,10.1101/055459,2230,English,http://biorxiv.org/content/early/2016/05/26/055459; files/1490/055459.html,,,,,,,"The recent emergence of Zika in Brazil and its association with increased congenital malformation rates has raised concerns over its impact on the birth rates in the country. Using data on the incidence of Zika in 2015-2016 and dengue in 2013 and 2015-16 for the city of Rio de Janeiro (pop: 6.4 million), we document a massive increase of Zika in women compared to men. Even after correcting for the bias due to the systematic testing of pregnant women for Zika, there are 90% more registered cases per 100,000 women in the sexually active age group (15-65 years) than for men but not before 15 or after 65. Assuming that infected men transmit the disease to women in their semen but that the converse is not true, some extra incidence in women is to be expected. An alternate hypothesis would be that women visit doctors more often than men. To test this, we compared the incidence of dengue fever in men and women in 2015 and in 2013 (before Zika reached Rio de Janeiro): in both years, women are 30% more likely to be reported with dengue. Summing up, women in the sexually active age bracket are far more likely to get Zika than men (+90% increase); sexual transmission is the most probable cause. Women in the 15-65 age group are also 30% more likely to be reported with dengue than men, which is probably due to women being more careful with their health.",BiorXiv,May 30, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,No,Original research,No,Yes,1120,Clinical/epidemiological research,Modelling study
1121,"Fonseca, Trab. educ. saúde, 2016",Fonseca,"Fonseca, Angélica Ferreira",Sobre o trabalho e a formação de agentes de saúde em tempos de zika^ipt; On the work and training of health agents in times of zika^ien; Sobre el trabajo y formación de agentes de salud en tiempo de zika^ies,Trab. educ. saúde,14,2,327-329,2016,2010-present,,,,2185,,http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1981-77462016000200327,,,,,,,,LILACS,May 30, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,1121,,
1122,"Calda, Aktualni Gynekologie a Porodnictvi, 2016",Calda,"Calda, P.; Brestak, M.; Sipek, A.; Machala, L.",Statement on the pregnancy management with suspicion of Zika virus infection: Czech society for ultrasound in obstetrics and gynecology. [Czech],Aktualni Gynekologie a Porodnictvi,8,,26-28,2016,2010-present,,20160316872,,2646,Other,http://www.actualgyn.com/; http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emed14&AN=20160316872; http://lshtmsfx.hosted.exlibrisgroup.com/lshtm?sid=OVID:embase&id=pmid:&id=doi:&issn=1803-9588&isbn=&volume=8&issue=&spage=26&pages=26-28&date=2016&title=Aktualni+Gynekologie+a+Porodnictvi&atitle=Stanovisko+k+managementu+tehotenstvi+pri+podezreni+na+infekci+virem+Zika%3A+Ceska+spolecnost+pro+ultrazvuk+v+porodnictvi+a+gynekologii+CLS+JEP&aulast=Calda&pid=%3Cauthor%3ECalda+P.%3BBrestak+M.%3BSipek+A.%3BMachala+L.%3C%2Fauthor%3E%3CAN%3E20160316872%3C%2FAN%3E%3CDT%3EJournal%3A+Article%3C%2FDT%3E,"(Calda, Brestak) Gynekologicko-porodnicka klinika, 1. LF UK a VFN v Praze, Apolinarska 18, Praha 2 128 51, Czech Republic (Sipek) Ustav biologie a lekarske genetiky, 1. LF UK a VFN v Praze, Czech Republic (Machala) Klinika infekcnich, parazitarnich a tropickych nemoci, 3. lekarske fakulty UK a Nemocnice Na Bulovce v Praze, Czech Republic; P. Calda, Gynekologicko-porodnicka klinika, 1. LF UK a VFN v Praze, Apolinarska 18, Praha 2 128 51, Czech Republic. E-mail: pavel.calda@lf1.cuni.cz",,,,,article; pregnancy; zika fever,,Embase,May 30, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Unknown/unclear,Original research,No,Yes,1122,Clinical/epidemiological research,Guidelines
1123,"Anderson, Ann Intern Med, 2016",Anderson,"Anderson, K. B.; Thomas, S. J.; Endy, T. P.",The Emergence of Zika Virus: A Narrative Review,Ann Intern Med,,,,2016,2010-present,,27135717,10.7326/M16-0617,2298,English,http://www.ncbi.nlm.nih.gov/pubmed/27135717,,,,,,,"Zika virus (ZIKV) is yet another arbovirus that is rapidly emerging on a global scale, on the heels of a chikungunya epidemic in the Americas that began in 2013. A ZIKV epidemic that began in Brazil in 2015 has now spread rapidly to more than 30 countries in the Americas and the Caribbean, infecting more than 2 million inhabitants. This epidemic currently continues unabated. The explosive nature of recent outbreaks and concerning links to Guillain-Barre syndrome and microcephaly are incompletely understood. Also unknown is the relative importance of sexual transmission of ZIKV and asymptomatic ZIKV infections to the overall burden of transmission. The limited understanding of ZIKV presents an enormous challenge for responses to this rapidly emerging threat to human health. This article reviews the existing literature on ZIKV and proposes critical questions for vaccine development and other areas of needed research.",Pubmed,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Yes,Review,No,Yes,1123,Clinical/epidemiological research,Epidemiological/clinical review
1124,"Rojas, bioRxiv, 2016",Rojas,"Rojas, Diana Patricia; Dean, Natalie E.; Yang, Yang; Kenah, Eben; Quintero, Juliana; Tomasi, Simon; Ramirez, Erika L.; Kelly, Yendy; Castro, Carolina; Carrasquilla, Gabriel; Halloran, M. Elizabeth; Longini, Ira M.","The Epidemiology and Transmissibility of Zika Virus in Girardot and San Andres Island, Colombia",bioRxiv,,,49957,2016,2010-present,,,10.1101/049957,2211,English,http://biorxiv.org/content/early/2016/04/24/049957,,,,,,,"Background: Zika virus (ZIKV) is an arbovirus in the same genus as dengue virus and yellow fever virus. ZIKV transmission was first detected in Colombia in September 2015. The virus has spread rapidly across the country in areas infested with the vector Aedes aegypti. As of March 2016, Colombia has reported over 50,000 cases of Zika virus disease (ZVD). Methods: We analyzed surveillance data of ZVD cases reported to the local health authorities of San Andres, Colombia, and Girardot, Colombia, between September 2015 and January 2016. Standardized case definitions used in both areas were determined by the Ministry of Health and Colombian National Institute of Health at the beginning of the ZIKV epidemic. ZVD was laboratory- confirmed by a finding of Zika virus RNA in the serum of acute cases. We report epidemiological summaries of the two outbreaks. We also use daily incidence data to estimate the basic reproductive number R0 in each population. Findings: We identified 928 and 1,936 laboratory or clinically confirmed cases in San Andres and Girardot, respectively. The overall attack rate for reported ZVD detected by healthcare local surveillance was 12.13 cases per 1,000 residents of San Andres and 18.43 cases per 1,000 residents of Girardot. Attack rates were significantly higher in females in both municipalities. Cases occurred in all age groups but the most affected group was 20 to 49 year olds. The estimated R0 for the Zika outbreak in San Andres was 1.41 (95% CI 1.15 to 1.74), and in Girardot was 4.61 (95% CI 4.11 to 5.16). Interpretation: Transmission of ZIKV is ongoing and spreading throughout the Americas rapidly. The observed rapid spread is supported by the relatively high basic reproductive numbers calculated from these two outbreaks in Colombia.",BiorXiv,May 30, 2016,Yes,,No,"Zika, not relevant to causality framework",Scientific (journal) article,No,Original research,No,Yes,1124,Clinical/epidemiological research,Modelling study
1125,"Frumence, Virology, 2016",Frumence,"Frumence, E.; Roche, M.; Krejbich-Trotot, P.; El-Kalamouni, C.; Nativel, B.; Rondeau, P.; Misse, D.; Gadea, G.; Viranaicken, W.; Despres, P.",The South Pacific epidemic strain of Zika virus replicates efficiently in human epithelial A549 cells leading to IFN-beta production and apoptosis induction,Virology,493,,217-26,2016,2010-present,,27060565,10.1016/j.virol.2016.03.006,2653,English,http://www.ncbi.nlm.nih.gov/pubmed/27060565,"Universite de la Reunion, UM 134 Processus Infectieux en Milieu Insulaire Tropical (PIMIT), INSERM U1187, CNRS UMR9192, IRD UMR249. Plateforme Technologique CYROI, 97490 Sainte Clotilde, France.; Universite de la Reunion, UMR Diabete Atherothrombose Therapies Reunion Ocean Indien (DeTROI), INSERM U1188, Plateforme Technologique CYROI, 97490 Sainte Clotilde, France.; Laboratoire MIVEGEC, UMR 224 IRD/CNRS/UM, 34394 Montpellier, France.; Universite de la Reunion, UM 134 Processus Infectieux en Milieu Insulaire Tropical (PIMIT), INSERM U1187, CNRS UMR9192, IRD UMR249. Plateforme Technologique CYROI, 97490 Sainte Clotilde, France. Electronic address: wildriss.viranaicken@univ-reunion.fr.; Universite de la Reunion, UM 134 Processus Infectieux en Milieu Insulaire Tropical (PIMIT), INSERM U1187, CNRS UMR9192, IRD UMR249. Plateforme Technologique CYROI, 97490 Sainte Clotilde, France. Electronic address: philippe.despres@univ-reunion.fr.",France,Europe,France,Public/Government,Apoptosis; Arbovirus; Emerging virus; Human epithelial cells; Innate immunity; Oxidative stress; Type-I interferon; Viral pathogenicity; Zika virus,"Zika virus (ZIKV) is an emerging flavivirus since the first epidemics in South Pacific in 2007. The recent finding that ZIKV is now circulating in Western Hemisphere and can be associated to severe human diseases, warrants the need for its study. Here we evaluate the susceptibility of human lung epithelial A549 cells to South Pacific epidemic strain of ZIKV isolated in 2013. We showed that ZIKV growth in A549 cells is greatly efficient. ZIKV infection resulted in the secretion of IFN-beta followed by the expression of pro-inflammatory cytokines such as IL-1beta, and transcriptional activity of IFIT genes. At the maximum of virus progeny production, ZIKV triggers mitochondrial apoptosis through activation of caspases-3 and -9. Whereas at early infection times, the rapid release of IFN-beta which exerts an antiviral effect against ZIKV might delay apoptosis in infected cells. ",Embase,May 30, 2016,Yes,,Yes,,Scientific (journal) article,Yes,Original research,No,Yes,1125,Basic and applied biomedical research,In vitro experiment
1126,"Bostikova, Vakcinologie, 2016",Bostikova,"Bostikova, V.; Kuca, K.; Sleha, R.; Pasdiorova, M.; Marek, J.; Bostik, P.",The need of Zika virus vaccine for pregnant women. [Czech],Vakcinologie,10,2,91-95,2016,2010-present,,20160358307,,2579,Other,http://www.vakcinologieaktualne.cz; http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emed14&AN=20160358307; http://lshtmsfx.hosted.exlibrisgroup.com/lshtm?sid=OVID:embase&id=pmid:&id=doi:&issn=1802-3150&isbn=&volume=10&issue=2&spage=91&pages=91-95&date=2016&title=Vakcinologie&atitle=Potreba+vakciny+proti+Zika+viru+pro+tehotne+zeny&aulast=Bostikova&pid=%3Cauthor%3EBostikova+V.%3BKuca+K.%3BSleha+R.%3BPasdiorova+M.%3BMarek+J.%3BBostik+P.%3C%2Fauthor%3E%3CAN%3E20160358307%3C%2FAN%3E%3CDT%3EJournal%3A+Article%3C%2FDT%3E,"(Bostikova, Sleha, Pasdiorova, Marek, Bostik) Katedra epidemiologie, FVZ UO, Hradec Kralove, Czech Republic (Kuca, Pasdiorova, Marek) Centrum biomedicinskeho vyzkumu, Fakultni nemocnice, Hradec Kralove, Czech Republic (Kuca) Katedra toxikologie a vojenske farmacie, FVZ UO, Hradec Kralove, Czech Republic; V. Bostikova, Katedra epidemiologie, Fakulta vojenskeho zdravotnictvi, Trebesska 1575, Hradec Kralove 500 01, Czech Republic. E-mail: vanda.bostikova@pmfhk.cz",,,,,article; female; human; pregnant woman; Zika virus vaccine,,Embase,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,1126,,
1127,"Benelli, Asian Pacific Journal of Tropical Disease, 2016",Benelli,"Benelli, G.; Canale, A.; Higuchi, A.; Murugan, K.; Pavela, R.; Nicoletti, M.",The recent outbreaks of Zika virus: Mosquito control faces a further challenge,Asian Pacific Journal of Tropical Disease,6,4,253-258,2016,2010-present,,20160332174,http://dx.doi.org/10.1016/S2222-1808%2815%2961025-8,2631,English,http://www.elsevier.com/wps/find/journaldescription.cws_home/726379/description#description; http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emed14&AN=20160332174; http://lshtmsfx.hosted.exlibrisgroup.com/lshtm?sid=OVID:embase&id=pmid:&id=doi:10.1016%2FS2222-1808%252815%252961025-8&issn=2222-1808&isbn=&volume=6&issue=4&spage=253&pages=253-258&date=2016&title=Asian+Pacific+Journal+of+Tropical+Disease&atitle=The+recent+outbreaks+of+Zika+virus%3A+Mosquito+control+faces+a+further+challenge&aulast=Benelli&pid=%3Cauthor%3EBenelli+G.%3BCanale+A.%3BHiguchi+A.%3BMurugan+K.%3BPavela+R.%3BNicoletti+M.%3C%2Fauthor%3E%3CAN%3E20160332174%3C%2FAN%3E%3CDT%3EJournal%3A+Article%3C%2FDT%3E,"(Benelli, Canale) Insect Behaviour Group, Department of Agriculture, Food and Environment, University of Pisa, via del Borghetto 80, Pisa 56124, Italy (Higuchi) Department of Chemical and Materials Engineering, National Central University, No. 300, Jhongli, Taoyuan 32001, Taiwan (Republic of China) (Murugan) Department of Zoology, School of Life Sciences, Bharathiar University, Coimbatore, Tamil Nadu 641 046, India (Pavela) Crop Research Institute, Drnovska 507, Prague 6 161 06, Czech Republic (Nicoletti) Department of Environmental Biology, Sapienza University of Rome, P.ale Aldo Moro 5, Rome 00185, Italy; G. Benelli, Insect Behaviour Group, Department of Agriculture, Food and Environment, University of Pisa, via del Borghetto 80, Pisa 56124, Italy. E-mail: g.benelli@sssup.it",,,,,Arbovirus; Asian tiger mosquito; Biological control agents; Biosafety; Culicidae; Dengue; Flavivirus; Green nanosynthesis; Integrated pest management; Aedes aegypti; Aedes albopictus; aquatic environment; article; Azadirachta indica; epidemic; Flavivirus infection; human; insect control; nonhuman; priority journal; vector control; Zika virus infection; insecticide,"The recent outbreaks of Zika virus infection occurring in South America, Central America and the Caribbean, represent the most recent of four key arrivals of arboviruses in the Western Hemisphere over the last 20 years. Zika virus is mainly vectored by Aedes mosquitoes. The development of effective and eco-friendly mosquito control methods is required in order to minimize the negative effects of currently marketed synthetic pesticides, including multidrug resistance. In this scenario, natural product research can afford solutions as part of integrated pest management strategies. In this review, we focused on neem (Azadirachta indica) products as sources of cheap control tools of Aedes vectors. Current knowledge on the larvicidal, pupicidal, adulticidal and oviposition deterrent potential of neem-borne products against the arbovirus vectors Aedes aegypti and Aedes albopictus is reviewed. Furthermore, we considered the rising importance of neem extraction by-products as sources of bio-reducing agents for the synthesis of nanoformulated mosquitocides. The last section examined biosafety and non-target effects on neem-borne mosquitocides in the aquatic environment. Overall, we support the employ of neem-borne molecules as an advantageous alternative to build newer and safer Aedes control tools, in the framework of Zika virus outbreak prevention.",Embase,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Yes,Review,No,Yes,1127,Environmental and vector research,Ecological/Vector review
1128,"Missier, arXiv, 2016",Missier,"Missier, Paolo; Romanovsky, Alexander; Miu, Tudor; Pal, Atinder; Daniilakis, Michael; Garcia, Alessandro; Cedrim, Diego; Sousa, Leonardo da Silva",Tracking Dengue Epidemics using Twitter Content Classification and Topic Modelling,arXiv,,,,2016,2010-present,,,,2254,,http://arxiv.org/abs/1605.00968,,,,,,Computer Science - Social and Information Networks,"Detecting and preventing outbreaks of mosquito-borne diseases such as Dengue and Zika in Brasil and other tropical regions has long been a priority for governments in affected areas. Streaming social media content, such as Twitter, is increasingly being used for health vigilance applications such as flu detection. However, previous work has not addressed the complexity of drastic seasonal changes on Twitter content across multiple epidemic outbreaks. In order to address this gap, this paper contrasts two complementary approaches to detecting Twitter content that is relevant for Dengue outbreak detection, namely supervised classification and unsupervised clustering using topic modelling. Each approach has benefits and shortcomings. Our classifier achieves a prediction accuracy of about 80\% based on a small training set of about 1,000 instances, but the need for manual annotation makes it hard to track seasonal changes in the nature of the epidemics, such as the emergence of new types of virus in certain geographical locations. In contrast, LDA-based topic modelling scales well, generating cohesive and well-separated clusters from larger samples. While clusters can be easily re-generated following changes in epidemics, however, this approach makes it hard to clearly segregate relevant tweets into well-defined clusters.",ArXiv,May 30, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,No,Original research,No,Yes,1128,Clinical/epidemiological research,Modelling study
1129,"Acosta, Revista Colombiana de Anestesiología, 2016",Acosta,"Acosta, Orlando",Virus de Zika: se expande su culpabilidad por asociación,Revista Colombiana de Anestesiología,44,2,83-85,2016,2010-present,,20160292271,10.1016/j.rca.2016.03.001,2616,Spanish,http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emed14&AN=20160292271; http://lshtmsfx.hosted.exlibrisgroup.com/lshtm?sid=OVID:embase&id=pmid:&id=doi:10.1016%2Fj.rca.2016.03.001&issn=0120-3347&isbn=&volume=44&issue=2&spage=83&pages=83-85&date=2016&title=Revista+Colombiana+de+Anestesiologia&atitle=Virus+de+Zika%3A+Se+expande+su+culpabilidad+por+asociacion&aulast=Acosta&pid=%3Cauthor%3EAcosta+O.%3C%2Fauthor%3E%3CAN%3E20160292271%3C%2FAN%3E%3CDT%3EJournal%3A+Editorial%3C%2FDT%3E; http://ac.els-cdn.com/S0120334716000216/1-s2.0-S0120334716000216-main.pdf?_tid=0ac2fe4a-2672-11e6-b48f-00000aab0f01&acdnat=1464618373_e4143ab460f55d6f450564f04491cc89,"(Acosta) Departamento de Ciencias Fisiologicas, Facultad de Medicina, Universidad Nacional de Colombia, Bogota D.C., Colombia; O. Acosta, Departamento de Ciencias Fisiologicas, Facultad de Medicina, Universidad Nacional de Colombia, Ciudad Universitaria, Carrera 30 No. 45-03, Bogota D.C., Colombia. E-mail: oacostal@unal.edu.co",,,,,editorial; nonhuman; virogenesis; zika virus,,Embase,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,1129,,
1130,"Lucey, International Journal of Infectious Diseases, 2016",Lucey,"Lucey, D.",WHO reforms and UN actions,International Journal of Infectious Diseases,45,,13,2016,2010-present,,72245030,10.1016/j.ijid.2016.02.062,2656,English,http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emed13&AN=72245030; http://lshtmsfx.hosted.exlibrisgroup.com/lshtm?sid=OVID:embase&id=pmid:&id=doi:10.1016%2Fj.ijid.2016.02.062&issn=1201-9712&isbn=&volume=45&issue=&spage=13&pages=13&date=2016&title=International+Journal+of+Infectious+Diseases&atitle=WHO+reforms+and+UN+actions&aulast=Lucey&pid=%3Cauthor%3ELucey+D.%3C%2Fauthor%3E%3CAN%3E72245030%3C%2FAN%3E%3CDT%3EJournal%3A+Conference+Abstract%3C%2FDT%3E; http://ac.els-cdn.com/S1201971216300418/1-s2.0-S1201971216300418-main.pdf?_tid=77010b60-2672-11e6-862f-00000aab0f6b&acdnat=1464618554_6ec92ae60c1c1d98923032da978ec922,"(Lucey) Georgetown University, Washington, DC, United States; D. Lucey, Georgetown University, Washington, DC, United States",,,,,infection; world health organization; Ebola hemorrhagic fever; Africa; epidemic; pandemic; emergency; virus; United Nations; disaster; health; sand; public health; microcephaly; leadership; moon,"This presentation will summarize five reports and commissions released between July 2014-Feb 2015 that address the response to the catastrophic Ebola epidemic in West Africa and recommend changes to prepare better for future infectious disease outbreaks, crises, and emergencies. The focus will be on World Health Organization (WHO) reforms and actions by the United Nations (UN). These reports and commissions include, but may not be limited to: (1) July 7, 2015. Report of the Ebola Interim Assessment Panel. Chaired by Dame Barbara Stocking. (2) Nov 22, 2015 published online in the Lancet. Moon S. et al. Will Ebola change the game? Ten essential reforms before the next pandemic. The report of the Harvard-LSTMH Independent Panel on the Global Response to Ebola. (3) Jan 13, 2016. The Neglected Dimensions of Global Security: A Framework to Counter Infectious Disease Crises. Chaired by Peter Sands. (4) Jan 18, 2016 (Second and Final Report). Advisory Group on Reform of WHO's Work in Outbreaks and Emergencies. Chaired by Dr. David Nabarro. (5). Feb 2016 (anticipated publication): The United Nations Secretary-General's High-Level Panel on the Global Response to Health Crises. While awaiting implementation of much-needed WHO Reform, as revealed by the Ebola catastrophe in West Africa, the emerging pandemic of Zika virus, and possibly-related microcephaly, was recognized. Lucey and Gostin. The Emerging Zika Pandemic: Enhancing Preparedness. JAMA published online (Wednesday) Jan 27, 2016 (online) called on the WHO Director-General to apply one of the most crucial lessons that should have been learned from the delayed WHO response to the Ebola epidemic in West Africa, and to no longer delay convening theWHOEmergency Committee to advise whether to declare a Public Health Emergency of International Concern (PHEIC) related to the Zika virus crises and to provide global guidance and leadership accordingly.",Embase,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,1130,,
1131,"Molenaar-Hoogendijk, Huisarts en wetenschap, 2016",Molenaar-Hoogendijk,"Molenaar-Hoogendijk, Marina; Nusteling, Laura; Boute, Frans",Zika,Huisarts en wetenschap,59,4,180-180,2016,2010-present,,20160296856,10.1007/s12445-016-0105-1,2667,Other,http://www.springerlink.com/content/0018-7070; http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emed14&AN=20160296856; http://lshtmsfx.hosted.exlibrisgroup.com/lshtm?sid=OVID:embase&id=pmid:&id=doi:10.1007%2Fs12445-016-0105-1&issn=0018-7070&isbn=&volume=59&issue=4&spage=180&pages=180&date=2016&title=Huisarts+en+Wetenschap&atitle=Zika&aulast=Molenaar-Hoogendijk&pid=%3Cauthor%3EMolenaar-Hoogendijk+M.%3BNusteling+L.%3BBoute+F.%3C%2Fauthor%3E%3CAN%3E20160296856%3C%2FAN%3E%3CDT%3EJournal%3A+Article%3C%2FDT%3E; http://download.springer.com/static/pdf/842/art%253A10.1007%252Fs12445-016-0105-1.pdf?originUrl=http%3A%2F%2Flink.springer.com%2Farticle%2F10.1007%2Fs12445-016-0105-1&token2=exp=1464619407~acl=%2Fstatic%2Fpdf%2F842%2Fart%25253A10.1007%25252Fs12445-016-0105-1.pdf%3ForiginUrl%3Dhttp%253A%252F%252Flink.springer.com%252Farticle%252F10.1007%252Fs12445-016-0105-1*~hmac=20b3c55a3aed0b90cd756a6b34d30ed8aa1ce8f96aad76ab95e2ebcbfaee6f37,"(Molenaar-Hoogendijk, Nusteling, Boute) Huisartsenpraktijk Boute, Medisch punt Charlois, Boergoensestraat 74, Rotterdam, KC 3082, Netherlands; M. Molenaar-Hoogendijk, Huisartsenpraktijk Boute, Medisch punt Charlois, Netherlands",,,,,article; nonhuman; virus; Zika virus,,Embase,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,1131,,
1132,"Malone, bioRxiv, 2016",Malone,"Malone, Robert W.; Klase, Zachary; Khakhina, Svetlana; Callahan, Michael V.; Glasspool-Malone, Jill; Schneider, Adriano De Bernardi",Zika Fetal Neuropathogenesis: Etiology of a Viral Syndrome,bioRxiv,,,50674,2016,2010-present,,,10.1101/050674,2260,English,http://biorxiv.org/content/early/2016/05/08/050674,,,,,,,"The ongoing Zika Virus epidemic in the Americas, and the observed association with both fetal abnormalities (primary microcephaly) and adult autoimmune pathology (Guillain-Barre syndrome) has brought attention to this neglected pathogen. While initial case studies generated significant interest in the Zika virus outbreak, larger prospective epidemiology and basic virology studies examining the mechanisms of Zika viral infection and associated pathophysiology are only now starting to be published. In this review, we analyze Zika fetal neuropathogenesis from a comparative pathology perspective, using the historic metaphor of TORCH viral pathogenesis to provide context. By drawing parallels to other viral infections of the fetus, we identify common themes and mechanisms that may illuminate the observed pathology. The existing data on the susceptibility of various cells to both Zika and other flavivirus infections are summarized. Finally, we highlight relevant aspects of the known molecular mechanisms of flavivirus replication.",BiorXiv,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,No,Review,No,Yes,1132,Clinical/epidemiological research,Epidemiological/clinical review
1133,"Musso, Clin Microbiol Rev, 2016",Musso,"Musso, D.; Gubler, D. J.",Zika Virus,Clin Microbiol Rev,29,3,487-524,2016,2010-present,,27029595,10.1128/CMR.00072-15,2676,English,http://www.ncbi.nlm.nih.gov/pubmed/27029595,"Unit of Emerging Infectious Diseases, Institut Louis Malarde, Tahiti, French Polynesia dmusso@ilm.pf duane.gubler@duke-nus.edu.sg.; Program in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore Partnership for Dengue Control, Lyon, France dmusso@ilm.pf duane.gubler@duke-nus.edu.sg.",,,,,Aedes aegypti; Aedes albopictus; Africa; Arbovirus; article; Asia; Flaviviridae; human; laboratory test; microcephaly/co [Complication]; neurologic disease/co [Complication]; nonhuman; phylogeny; serology; urban area; virus classification; virus detection; virus infection/di [Diagnosis]; virus infection/et [Etiology]; virus infection/pc [Prevention]; virus transmission; zika fever/di [Diagnosis]; zika fever/et [Etiology]; zika fever/pc [Prevention]; Zika virus; antihistaminic agent; paracetamol,"Zika virus (ZIKV) is an arthropod-borne virus (arbovirus) in the genus Flavivirus and the family Flaviviridae. ZIKV was first isolated from a nonhuman primate in 1947 and from mosquitoes in 1948 in Africa, and ZIKV infections in humans were sporadic for half a century before emerging in the Pacific and the Americas. ZIKV is usually transmitted by the bite of infected mosquitoes. The clinical presentation of Zika fever is nonspecific and can be misdiagnosed as other infectious diseases, especially those due to arboviruses such as dengue and chikungunya. ZIKV infection was associated with only mild illness prior to the large French Polynesian outbreak in 2013 and 2014, when severe neurological complications were reported, and the emergence in Brazil of a dramatic increase in severe congenital malformations (microcephaly) suspected to be associated with ZIKV. Laboratory diagnosis of Zika fever relies on virus isolation or detection of ZIKV-specific RNA. Serological diagnosis is complicated by cross-reactivity among members of the Flavivirus genus. The adaptation of ZIKV to an urban cycle involving humans and domestic mosquito vectors in tropical areas where dengue is endemic suggests that the incidence of ZIKV infections may be underestimated. There is a high potential for ZIKV emergence in urban centers in the tropics that are infested with competent mosquito vectors such as Aedes aegypti and Aedes albopictus.",Embase,May 30, 2016,No,Duplicate of existing record,,,,,,,,,,
1134,"Löwy, Physis (Rio J.), 2016",Löwy,"Löwy, Ilana",Zika and Microcephaly: can we learn from history?,Physis (Rio J.),26,1,Nov 21,2016,2010-present,,,,2210,,http://www.scielosp.org/scielo.php?script=sci_arttext&pid=S0103-73312016000100011,,,,,,,,LILACS,May 30, 2016,Yes,,No,"Zika, no original information (e.g. editorial)",Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,1134,,
1135,"Bastos, bioRxiv, 2016",Bastos,"Bastos, Leonardo; Villela, Daniel A. M.; Carvalho, Luiz Max; Cruz, Oswaldo G.; Gomes, Marcelo F. C.; Durovni, Betina; Lemos, Maria Cristina; Saraceni, Valeria; Coelho, Flavio C.; Codeco, Claudia T.",Zika in Rio de Janeiro: Assessment of basic reproductive number and its comparison with dengue,bioRxiv,,,55475,2016,2010-present,,,10.1101/055475,2240,English,http://biorxiv.org/content/early/2016/05/25/055475,,,,,,,"Zika virus infection was declared a public health emergency of international concern in February 2016 in response to the outbreak in Brazil and its suspected link with congenital anomalies. In this study we use early notification data and disease natural history parameters to estimate the basic reproductive number R0. Our estimates of the basic reproductive number for Zika in Rio de Janeiro (R0=3.9, 95% CI: 3.1 -- 5.3) were higher than those obtained for dengue using data from two early epidemics in the city (year 2002: 2.5 [2.1 -- 3.1]; year 2012: 1.5 [1.4 -- 1.8]). Given the role of Aedes aegypti as an arbovirus vector, we also assessed the R0 of Zika given entomological and epidemiological factors already reported for dengue transmission. Surprisingly, we find that Zika's R0 under a vectorial-only transmission model is lower than the basic reproductive number for dengue. These results suggest that either our current knowledge regarding the vectorial capacity of Aedes aegypti as a vector for Zika is incomplete or other modes of transmission are important players in sustaining this epidemic.",BiorXiv,May 30, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,No,Original research,No,Yes,1135,Clinical/epidemiological research,Modelling study
1136,"Ogunbanjo, South African Family Practice, 2016",Ogunbanjo,"Ogunbanjo, G. A.",Zika virus disease (ZVD): Another viral disease outbreak,South African Family Practice,58,1,,2016,2010-present,,20160308508,,2747,English,http://reference.sabinet.co.za/webx/access/electronic_journals/mp_safp/mp_safp_v58_n1_a1.pdf; http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emed14&AN=20160308508; http://lshtmsfx.hosted.exlibrisgroup.com/lshtm?sid=OVID:embase&id=pmid:&id=doi:&issn=1726-426X&isbn=&volume=58&issue=1&spage=no+pagination&pages=no+pagination&date=2016&title=South+African+Family+Practice&atitle=Zika+virus+disease+%28ZVD%29%3A+Another+viral+disease+outbreak&aulast=Ogunbanjo&pid=%3Cauthor%3EOgunbanjo+G.A.%3C%2Fauthor%3E%3CAN%3E20160308508%3C%2FAN%3E%3CDT%3EJournal%3A+Editorial%3C%2FDT%3E,,,,,,clinical feature; disease transmission; editorial; Guillain Barre syndrome; human; microcephaly; mosquito bite; pregnancy; reverse transcription polymerase chain reaction; sexual intercourse; unprotected sex; virus infection; Zika virus infection; insect repellent; insecticide,,Embase,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,1136,,
1137,"Hohmann-Jeddi, Pharmazeutische Zeitung, 2016",Hohmann-Jeddi,"Hohmann-Jeddi, C.",Zika virus increases risk of Guillain-Barre syndrome,Pharmazeutische Zeitung,161,10,,2016,2010-present,,20160228011,,2637,English,http://www.pharmazeutische-zeitung.de/index.php?id=62395; http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emed13&AN=20160228011; http://lshtmsfx.hosted.exlibrisgroup.com/lshtm?sid=OVID:embase&id=pmid:&id=doi:&issn=0031-7136&isbn=&volume=161&issue=10&spage=no+pagination&pages=no+pagination&date=2016&title=Pharmazeutische+Zeitung&atitle=Zika-Virus+erhoht+Risiko+fur+Guillain-Barre-Syndrom&aulast=Hohmann-Jeddi&pid=%3Cauthor%3EHohmann-Jeddi+C.%3C%2Fauthor%3E%3CAN%3E20160228011%3C%2FAN%3E%3CDT%3EJournal%3A+Article%3C%2FDT%3E,,,,,,article; Guillain Barre syndrome; virus; Zika virus,,Embase,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,1137,,
1138,"Gogia, Current Medicine Research and Practice, 2016",Gogia,"Gogia, A.; Kakar, A.",Zika virus disease: What physicians must know,Current Medicine Research and Practice,6,3,123-125,2016,2010-present,,20160344934,doi:10.1016/j.cmrp.2016.05.001,2614,English,http://www.journals.elsevier.com/current-medicine-research-and-practice/; http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emed14&AN=20160344934; http://lshtmsfx.hosted.exlibrisgroup.com/lshtm?sid=OVID:embase&id=pmid:&id=doi:10.1016%2Fj.cmrp.2016.03.003&issn=2352-0817&isbn=&volume=6&issue=2&spage=95&pages=95&date=2016&title=Current+Medicine+Research+and+Practice&atitle=Zika+virus+infection+in+pregnant+women+in+Rio+de+Janeiro&aulast=Gogia&pid=%3Cauthor%3EGogia+A.%3BKakar+A.%3C%2Fauthor%3E%3CAN%3E20160344934%3C%2FAN%3E%3CDT%3EJournal%3A+Note%3C%2FDT%3E; http://www.sciencedirect.com/science/article/pii/S2352081716300228,"(Gogia, Kakar) Department of Medicine, Sir Ganga Ram Hospital, New Delhi, India; A. Gogia, Department of Medicine, Sir Ganga Ram Hospital, New Delhi, India. E-mail: atulgogia@yahoo.com",,,,,artery blood flow; arthralgia; blood sampling; blood vessel calcification; case report; central nervous system disease; conjunctivitis; Doppler ultrasonography; female; fetus death; fetus echography; fever; Flaviviridae; headache; human; intrauterine growth retardation; lymphadenopathy; maculopapular rash; note; placenta insufficiency; pregnant woman; prospective study; reverse transcription polymerase chain reaction; umbilical artery; urinalysis; virus infection/di [Diagnosis]; Zika virus infection/di [Diagnosis],,Embase,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Yes,Review,No,Yes,1138,Clinical/epidemiological research,Epidemiological/clinical review
1139,"Ze-Ze, IDCases, 2016",Ze-Ze,"Ze-Ze, L.; Prata, M. B.; Teixeira, T.; Marques, N.; Mondragao, A.; Fernandes, R.; Saraiva da Cunha, J.; Alves, M. J.","Zika virus infections imported from Brazil to Portugal, 2015",IDCases,4,,46-9,2016,2010-present,,27134823,10.1016/j.idcr.2016.03.004,2644,English,http://www.ncbi.nlm.nih.gov/pubmed/27134823,"Centro de Estudos de Vectores e Doencas Infecciosas, Instituto Nacional de Saude Dr. Ricardo Jorge, Aguas de Moura, Portugal; Biosystems & Integrative Sciences Institute, University of Lisbon, Faculty of Sciences, Campo Grande, Lisbon, Portugal.; Servico de Doencas Infecciosas, Centro Hospitalar e Universitario de Coimbra, Coimbra, Portugal.; Unidade de Doencas Infecciosas/Servico de Medicina Interna, Centro Hospitalar de Vila Nova de Gaia/Espinho, Vila Nova de Gaia, Portugal.; Centro de Estudos de Vectores e Doencas Infecciosas, Instituto Nacional de Saude Dr. Ricardo Jorge, Aguas de Moura, Portugal.",,,,,Arbovirus; Imported cases; Zika virus,"Zika virus is an emerging arbovirus transmitted by Aedes sp. mosquitoes like the Dengue and Chikungunya viruses. Zika virus was until recently considered a mild pathogenic mosquito-borne flavivirus with very few reported benign human infections. In 2007, an epidemic in Micronesia initiated the turnover in the epidemiological history of Zika virus and more recently, the potential association with congenital microcephaly cases in Brazil 2015, still under investigation, led the World Health Organization (WHO) to declare a Public Health Emergency of International Concern on February 1, 2016. Here, we present the clinical and laboratory aspects related to the first four imported human cases of Zika virus in Portugal from Brazil, and alert, regarding the high level of traveling between Portugal and Brazil, and the ongoing expansion of this virus in the Americas, for the threat for Zika virus introduction in Europe and the possible introduction to Madeira Island where Aedes aegypti is present.",Pubmed,May 30, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,Yes,Original research,No,Yes,1139,Clinical/epidemiological research,Case series
1140,"Hohmann-Jeddi, Pharmazeutische Zeitung, 2016",Hohmann-Jeddi,"Hohmann-Jeddi, C.",Zika virus infects cortical precursor cells,Pharmazeutische Zeitung,161,10,,2016,2010-present,,20160228012,,2642,English,http://www.pharmazeutische-zeitung.de/index.php?id=62395; http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emed13&AN=20160228012; http://lshtmsfx.hosted.exlibrisgroup.com/lshtm?sid=OVID:embase&id=pmid:&id=doi:&issn=0031-7136&isbn=&volume=161&issue=10&spage=no+pagination&pages=no+pagination&date=2016&title=Pharmazeutische+Zeitung&atitle=Zika-Virus+infiziert+kortikale+Vorlauferzellen&aulast=Hohmann-Jeddi&pid=%3Cauthor%3EHohmann-Jeddi+C.%3C%2Fauthor%3E%3CAN%3E20160228012%3C%2FAN%3E%3CDT%3EJournal%3A+Article%3C%2FDT%3E,,,,,,article; cell damage; cortical precursor cell; stem cell; virus infection; Zika virus infection,,Embase,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,1140,,
1141,"Yasmin, PeerJ Preprints, 2016",Yasmin,"Yasmin, Zarrin Basharat; Tabeer Khan; Azra",Zika virus phosphoproteome through the computational looking-glass and what we found there?,PeerJ Preprints,,,,2016,2010-present,,,https://doi.org/10.7287/peerj.preprints.2047v2,2726,,https://peerj.com/preprints/2047/,,,,,,,,PeerJ Preprints,May 30, 2016,Yes,,No,"Zika, not relevant to causality framework",Scientific (journal) article,No,Original research,No,Yes,1141,Basic and applied biomedical research,Sequence analysis and phylogenetics
1142,"Jupille, bioRxiv, 2016",Jupille,"Jupille, Henri; Seixas, Goncalo; Mousson, Laurence; Sousa, Carla; Failloux, Anna-Bella","Zika virus, a new threat for Europe?",bioRxiv,,,48454,2016,2010-present,,,10.1101/048454,2237,English,http://biorxiv.org/content/early/2016/04/13/048454,,,,,,,"Background: Since its emergence in 2007 in Micronesia and Polynesia, the arthropod-borne flavivirus Zika virus (ZIKV) has spread in the Americas and the Caribbean, following first detection in Brazil in May 2015. The risk of ZIKV emergence in Europe increases as imported cases are repeatedly reported. Together with chikungunya virus (CHIKV) and dengue virus (DENV), ZIKV is transmitted by Aedes mosquitoes. Any countries where these mosquitoes are present could be potential sites for future ZIKV outbreak. Methodology/Principal Findings: Mosquito females were challenged with an Asian genotype of ZIKV. Fully engorged mosquitoes were then maintained in insectary conditions . 16-24 mosquitoes from each population were examined at 3, 6, 9 and 14 days post-infection to estimate the infection, disseminated infection and transmission rates. Based on these experimental infections, we demonstrated that Ae. albopictus from France were not very susceptible to ZIKV. Conclusions/Significance: In combination with the restricted distribution and lower population densities of European Ae. albopictus, our results corroborate the low risk for ZIKV to expand into most parts of Europe with the possible exception of the warmest regions bordering the Mediterranean coastline.",BiorXiv,May 30, 2016,No,"Zika, not relevant to causality framework",,,Scientific (journal) article,No,Original research,No,Yes,1142,Environmental and vector research,Vector competence studies
1143,"Anonymous, Deutsche Apotheker Zeitung, 2016",Anonymous,Anonymous,Zika viruses bear the blame: A precisely documented case of fetal microcephaly,Deutsche Apotheker Zeitung,156,7,,2016,2010-present,,20160228220,,2571,English,https://www.deutsche-apotheker-zeitung.de/daz-az/2016/daz-7-2016/60-000-pillen-danach-im-monat; http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emed13&AN=20160228220; http://lshtmsfx.hosted.exlibrisgroup.com/lshtm?sid=OVID:embase&id=pmid:&id=doi:&issn=0011-9857&isbn=&volume=156&issue=7&spage=no+pagination&pages=no+pagination&date=2016&title=Deutsche+Apotheker+Zeitung&atitle=PRISMA%3A+Zika-Viren+sind+schuld%3A+Ein+genau+dokumentierter+Fall+von+fetaler+Mikrozephalie&aulast=&pid=%3Cauthor%3Eanonymous%3C%2Fauthor%3E%3CAN%3E20160228220%3C%2FAN%3E%3CDT%3EJournal%3A+Short+Survey%3C%2FDT%3E,,,,,,fetus; Flavivirus; human; microcephaly; nonhuman; short survey; virus infection; Zika virus,,Embase,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,1143,,
1144,"González, Arch. pediatr. Urug, 2016",González,"González, Sebastián",Zika y zikafobia: una página en construcciónies; Zika and zikaphobia: a page under construction,Arch. pediatr. Urug,87,1,53-61,2016,2010-present,,,,2170,,http://www.scielo.edu.uy/scielo.php?script=sci_arttext&pid=S1688-12492016000100010,,,,,,,,LILACS,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,1144,,
1145,"Tambyah, International Journal of Infectious Diseases, 2016",Tambyah,"Tambyah, P. A.","Zika, MERS, Ebola, SARS and H1N1: Local and global responses to viral threats",International Journal of Infectious Diseases,45,,63,2016,2010-present,,72245137,10.1016/j.ijid.2016.02.182,2680,English,http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emed13&AN=72245137; http://lshtmsfx.hosted.exlibrisgroup.com/lshtm?sid=OVID:embase&id=pmid:&id=doi:10.1016%2Fj.ijid.2016.02.182&issn=1201-9712&isbn=&volume=45&issue=&spage=63&pages=63&date=2016&title=International+Journal+of+Infectious+Diseases&atitle=Zika%2C+MERS%2C+Ebola%2C+SARS+and+H1N1%3A+Local+and+global+responses+to+viral+threats&aulast=Tambyah&pid=%3Cauthor%3ETambyah+P.A.%3C%2Fauthor%3E%3CAN%3E72245137%3C%2FAN%3E%3CDT%3EJournal%3A+Conference+Abstract%3C%2FDT%3E; http://ac.els-cdn.com/S1201971216301618/1-s2.0-S1201971216301618-main.pdf?_tid=744f7ffa-2672-11e6-9536-00000aacb361&acdnat=1464618550_e2a1479219f8f111af7d061614f7d953,"(Tambyah) National University Health System, Singapore, Singapore; P.A. Tambyah, National University Health System, Singapore, Singapore",,,,,Ebola hemorrhagic fever; infection; severe acute respiratory syndrome; therapy; pathogenesis; virus; pandemic influenza; Nipah virus; shoe; microbiology; molecular epidemiology; diagnosis; dengue; clinical trial (topic); risk; interpersonal communication; community; prevention and control; virulence; epidemic; epidemiology; chikungunya; virus infection; vaccine,"We live in a world with the constant threat of emerging viral infections. In the last two decades, we have seen the highly publicised emergence of the Nipah Virus, SARS, MERS, the re-emergence of Ebola and the H1N1 2009 pandemic influenza together with a host of other emerging and re-emerging viruses including Zika, Chikungunya, Dengue. As clinicians, we are the front line of response to these threats and the key to the response has to be good surveillance and clinical management. High quality clinical microbiology support is critical as is both 'shoe-leather' and molecular epidemiology. Only after the diagnosis has been clearly established and the epidemiology clarified, can quality clinical trials be considered for therapeutics and vaccines although the development could begin as soon as a novel pathogen is identified. We have learned many lessons from the responses both local and global to these new viral threats. One important one is the role of risk communication both among staff and the public. This is often ignored at our own peril as the responses of the community often have a disproportionate role in our work in controlling these infectious threats. Despite the billions of dollars poured into the prevention and control of these infections, most are without effective vaccines or therapeutics. There are also a number of emerging issues in pathogenesis and virulence which have yet to be answered. The task ahead is daunting but with good international collaboration, we have the opportunity to make a significant difference in the next emerging viral threat while not ignoring the current smouldering epidemics and endemic infections around us.",Embase,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,1145,,
1146,"Castellanos, Biomédica (Bogotá), 2016",Castellanos,"Castellanos, Jaime E.","Zika, evidencia de la derrota en la batalla contra Aedes aegyptiies; Zika: a defeat in the struggle against Aedes aegyptiien",Biomédica (Bogotá),36,1,05. Sep,2016,2010-present,,,,2178,,http://www.scielo.org.co/scielo.php?script=sci_arttext&pid=S0120-41572016000100001,,,,,,,,LILACS,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,1146,,
1147,"Camargo Jr, Physis (Rio J.), 2016",Camargo Jr,"Camargo Jr, Kenneth R. de","Zika, microcefalia, ciência e Saúde Coletiva",Physis (Rio J.),26,1,09. Okt,2016,2010-present,,,,2259,Portuguese,http://www.scielosp.org/scielo.php?script=sci_arttext&pid=S0103-73312016000100009,,,,,,,,LILACS,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,1147,,
1148,"Pardo-Turriago, Revista Colombiana de Anestesiología, 2016",Pardo-Turriago,"Pardo-Turriago, Rodrigo",Zika. Una pandemia en progreso y un reto epidemiológico,Revista Colombiana de Anestesiología,44,2,86-88,2016,2010-present,,20160316976,10.1016/j.rca.2016.04.001,2729,Spanish,http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emed14&AN=20160316976; http://lshtmsfx.hosted.exlibrisgroup.com/lshtm?sid=OVID:embase&id=pmid:&id=doi:10.1016%2Fj.rca.2016.04.001&issn=0120-3347&isbn=&volume=44&issue=2&spage=86&pages=86-88&date=2016&title=Revista+Colombiana+de+Anestesiologia&atitle=Zika.+Una+pandemia+en+progreso+y+un+reto+epidemiologico&aulast=Pardo-Turriago&pid=%3Cauthor%3EPardo-Turriago+R.%3C%2Fauthor%3E%3CAN%3E20160316976%3C%2FAN%3E%3CDT%3EJournal%3A+Editorial%3C%2FDT%3E; http://ac.els-cdn.com/S0120334716300235/1-s2.0-S0120334716300235-main.pdf?_tid=0868ba4a-2672-11e6-ab55-00000aacb360&acdnat=1464618369_ed6d61f4df0f6bc27837710c5649c606,"(Pardo-Turriago) Facultad de Medicina, Universidad Nacional de Colombia, Hospital Universitario Nacional de Colombia, Colombia; R. Pardo-Turriago, Facultad de Medicina, Universidad Nacional de Colombia, Hospital Universitario Nacional de Colombia, Colombia. E-mail: rpardot@unal.edu.co",,,,,disease course; editorial; nonhuman; pandemic; zika virus,,Embase,May 30, 2016,No,"Zika, no original information (e.g. editorial)",,,Scientific (journal) article,Unknown/unclear,Comment/Editorial/Perspective/Letter,No,Yes,1148,,
1149,"Vial Claro, Rev Chil Pediatr, 2016",Vial Claro,"Vial Claro, P. A.; Araos Bralic, R. I.",[Zika virus in a New World],Rev Chil Pediatr,87,2,79-81,2016,2010-present,,27032485,10.1016/j.rchipe.2016.02.005,2707,Spanish,http://www.ncbi.nlm.nih.gov/pubmed/27032485,"Instituto de Ciencias e Innovacion en Medicina, Facultad de Medicina, Clinica Alemana, Universidad del Desarrollo, Santiago, Chile; Servicio de Infectologia, Clinica Alemana de Santiago, Santiago, Chile. Electronic address: pvial@udd.cl.; Instituto de Ciencias e Innovacion en Medicina, Facultad de Medicina, Clinica Alemana, Universidad del Desarrollo, Santiago, Chile; Servicio de Infectologia, Clinica Alemana de Santiago, Santiago, Chile.",,,,,nonhuman; review; virus; zika virus,,Embase,May 30, 2016,No,Duplicate of existing record,,,,,,,,,,
1150,"Iwema, bioRxiv, 2016",Iwema,"Iwema, Carrie L.; LaDue, John; Zack, Angela; Chattopadhyay, Ansuman","search.bioPreprint: a discovery tool for cutting edge, preprint biomedical research articles",bioRxiv,,,52563,2016,2010-present,,,10.1101/052563,2232,English,http://biorxiv.org/content/early/2016/05/12/052563,,,,,,,"The time it takes for a completed manuscript to be published traditionally can be extremely lengthy. Article publication delay, which occurs in part due to constraints associated with peer review, can prevent the timely dissemination of critical and actionable data associated with new information on rare diseases or developing health concerns such as Zika virus. Preprint servers are open access online repositories housing preprint research articles that enable authors (1) to make their research immediately and freely available and (2) to receive commentary and peer review prior to journal submission. There is a growing movement of preprint advocates aiming to change the current journal publication and peer review system, proposing that preprints catalyze biomedical discovery, support career advancement, and improve scientific communication. While the number of articles submitted to and hosted by preprint servers are gradually increasing, there has been no simple way to identify biomedical research published in a preprint format, as they are not typically indexed and are only discoverable by directly searching the specific preprint server websites. To address this issue, we created a search engine that quickly compiles preprints from disparate host repositories and provides a one-stop search solution. Additionally, we developed a web application that bolsters the discovery of preprints by enabling each and every word or phrase appearing on any website to be integrated with articles from preprint servers. The bioPreprint search engine is publicly available at http://www.hsls.pitt.edu/resources/preprint.",BiorXiv,May 30, 2016,No,Unrelated to Zika virus,,,Scientific (journal) article,No,Comment/Editorial/Perspective/Letter,No,Yes,1150,,