Detection and differentiation of early acute and following age stages of myocardial infarction with quantitative post-mortem cardiac 1.5T MR.

Schwendener, Nicole; Jackowski, Christian; Persson, Anders; Warntjes, Marcel J; Schuster, Frederick; Riva, Fabiano; Zech, Wolf-Dieter (2016). Detection and differentiation of early acute and following age stages of myocardial infarction with quantitative post-mortem cardiac 1.5T MR. Forensic science international, 270, pp. 248-254. Elsevier Scientific Publ. Ireland 10.1016/j.forsciint.2016.10.014

[img] Text
1-s2.0-S0379073816304510-main.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (726kB) | Request a copy

Recently, quantitative MR sequences have started being used in post-mortem imaging. The goal of the present study was to evaluate if early acute and following age stages of myocardial infarction can be detected and discerned by quantitative 1.5T post-mortem cardiac magnetic resonance (PMCMR) based on quantitative T1, T2 and PD values. In 80 deceased individuals (25 female, 55 male), a cardiac MR quantification sequence was performed prior to cardiac dissection at autopsy in a prospective study. Focal myocardial signal alterations detected in synthetically generated MR images were MR quantified for their T1, T2 and PD values. The locations of signal alteration measurements in PMCMR were targeted at autopsy heart dissection and cardiac tissue specimens were taken for histologic examinations. Quantified signal alterations in PMCMR were correlated to their according histologic age stage of myocardial infarction. In PMCMR seventy-three focal myocardial signal alterations were detected in 49 of 80 investigated hearts. These signal alterations were diagnosed histologically as early acute (n=39), acute (n=14), subacute (n=10) and chronic (n=10) age stages of myocardial infarction. Statistical analysis revealed that based on their quantitative T1, T2 and PD values, a significant difference between all defined age groups of myocardial infarction can be determined. It can be concluded that quantitative 1.5T PMCMR quantification based on quantitative T1, T2 and PD values is feasible for characterization and differentiation of early acute and following age stages of myocardial infarction.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic, Interventional and Paediatric Radiology
04 Faculty of Medicine > Service Sector > Institute of Legal Medicine
04 Faculty of Medicine > Service Sector > Institute of Legal Medicine > Forensic Medicine
04 Faculty of Medicine > Service Sector > Institute of Legal Medicine > Forensic Physics (Ballistics)

UniBE Contributor:

Schwendener, Nicole; Jackowski, Christian; Schuster, Frederick; Riva, Fabiano and Zech, Wolf-Dieter

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0379-0738

Publisher:

Elsevier Scientific Publ. Ireland

Language:

English

Submitter:

Antoinette Angehrn

Date Deposited:

27 Dec 2016 16:21

Last Modified:

12 Jan 2017 01:31

Publisher DOI:

10.1016/j.forsciint.2016.10.014

PubMed ID:

27836412

Uncontrolled Keywords:

Heart; Infarction age; Myocardial infarction; Post-mortem imaging; Quantitative post-mortem cardiac MR

BORIS DOI:

10.7892/boris.90424

URI:

https://boris.unibe.ch/id/eprint/90424

Actions (login required)

Edit item Edit item
Provide Feedback