Tripod USPIONs with high aspect ratio show enhanced T2 relaxation and cytocompatibility

Wyss, Pradeep P; Lamichhane, Surya; Rauber, Martin; Thomann, Ralf; Krämer, Karl; Shastri, V Prasad (2016). Tripod USPIONs with high aspect ratio show enhanced T2 relaxation and cytocompatibility. Nanomedicine, 11(9), pp. 1017-1030. Future Medicine 10.2217/nnm.16.8

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We synthesized ultra-small iron oxide nanoparticles (USPIONs) with tripod
morphology and studied the effect of the aspect ratio (AR) of the tripod arms on
mass magnetization, T2 relaxation and cytocompatibility in human cell lines. Materials
& methods: Tripods were prepared by controlling the temperature during the
thermal decomposition of Fe(CO)5, and their magnetic properties were characterized
by superconducting quantum interference device, and NMR. Citric acid stabilized
USPIONs were used to assess cytocompatibility. Results: T2 relaxivity of tripods showed
dependency on AR of the tripod arm. Liver enzyme levels in presence of tripods
were comparable to spherical USPIONs, and surprisingly tripods induced lower levels
of reactive oxygen species. Conclusion: Tripod USPIONs with high AR arms possess
excellent magnetic properties and cytocompatibility for further exploration as MRI
contrast agents.

Item Type:

Journal Article (Original Article)

Division/Institute:

08 Faculty of Science > Department of Chemistry, Biochemistry and Pharmaceutical Sciences (DCBP)

UniBE Contributor:

Rauber, Martin and Krämer, Karl

Subjects:

500 Science > 570 Life sciences; biology
500 Science > 540 Chemistry

ISSN:

1748-6963

Publisher:

Future Medicine

Language:

English

Submitter:

Karl Krämer

Date Deposited:

24 Nov 2016 13:57

Last Modified:

22 Jan 2019 10:45

Publisher DOI:

10.2217/nnm.16.8

PubMed ID:

26983681

BORIS DOI:

10.7892/boris.90445

URI:

https://boris.unibe.ch/id/eprint/90445

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