Sleep-wake disturbances in the premotor and early stage of Parkinson's disease.

Bargiotas, Panagiotis; Schüpbach, Michael; Bassetti, Claudio (2016). Sleep-wake disturbances in the premotor and early stage of Parkinson's disease. Current opinion in neurology, 29(6), pp. 763-772. Lippincott Williams & Wilkins 10.1097/WCO.0000000000000388

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PURPOSE OF REVIEW Review of recent literature pertaining to frequency, associations, mechanisms, and overall significance of sleep--wake disturbances (SWD) in the premotor and early phase of Parkinson's disease. RECENT FINDINGS SWD are frequent in Parkinson's disease and their prevalence increases with disease progression. Recent studies confirm previous findings that SWD can appear as initial manifestation of Parkinson's disease even decades before motor signs appear and highlight their clinical associations in these early stages. More intriguingly, new evidence underpins their role as risk factors, predictors, or even as driving force for the neurodegenerative process. As our understanding of sleep--wake neurobiology increases, new hypotheses emerge concerning the pathophysiology of SWD in early Parkinson's disease stages involving dopaminergic and nondopaminergic mechanisms. SUMMARY SWD are predictors for the development of parkinsonian syndromes including Parkinson's disease. This may offer the opportunity of developing new preventive strategies and interventions at an early stage of this neurodegenerative disease.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DCR Unit Sahli Building > Forschungsgruppe Neurologie
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology

UniBE Contributor:

Bargiotas, Panagiotis; Schüpbach, Michael and Bassetti, Claudio

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1350-7540

Publisher:

Lippincott Williams & Wilkins

Language:

English

Submitter:

Stefanie Hetzenecker

Date Deposited:

13 Jan 2017 17:08

Last Modified:

01 Jan 2018 02:31

Publisher DOI:

10.1097/WCO.0000000000000388

PubMed ID:

27798423

BORIS DOI:

10.7892/boris.90718

URI:

https://boris.unibe.ch/id/eprint/90718

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