Cozac, Vitalii V; Ehrensperger, Michael M; Gschwandtner, Ute; Hatz, Florian; Meyer, Antonia; Monsch, Andreas U; Schüpbach, Michael; Taub, Ethan; Fuhr, Peter (2016). Older Candidates for Subthalamic Deep Brain Stimulation in Parkinson's Disease Have a Higher Incidence of Psychiatric Serious Adverse Events. Frontiers in aging neuroscience, 8(132), p. 132. Frontiers Research Foundation 10.3389/fnagi.2016.00132
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OBJECTIVE
To investigate the incidence of serious adverse events (SAE) of subthalamic deep brain stimulation (STN-DBS) in elderly patients with Parkinson's disease (PD).
METHODS
We investigated a group of 26 patients with PD who underwent STN-DBS at mean age 63.2 ± 3.3 years. The operated patients from the EARLYSTIM study (mean age 52.9 ± 6.6) were used as a comparison group. Incidences of SAE were compared between these groups.
RESULTS
A higher incidence of psychosis and hallucinations was found in these elderly patients compared to the younger patients in the EARLYSTIM study (p < 0.01).
CONCLUSIONS
The higher incidence of STN-DBS-related psychiatric complications underscores the need for comprehensive psychiatric pre- and postoperative assessment in older DBS candidates. However, these psychiatric SAE were transient, and the benefits of DBS clearly outweighed its adverse effects.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DCR Unit Sahli Building > Forschungsgruppe Neurologie 04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology |
UniBE Contributor: |
Schüpbach, Michael |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1663-4365 |
Publisher: |
Frontiers Research Foundation |
Language: |
English |
Submitter: |
Stefanie Hetzenecker |
Date Deposited: |
13 Jan 2017 17:37 |
Last Modified: |
05 Dec 2022 15:00 |
Publisher DOI: |
10.3389/fnagi.2016.00132 |
PubMed ID: |
27375478 |
Uncontrolled Keywords: |
Parkinson's disease (PD); adverse events; age factors; deep brain stimulation (DBS); psychosis |
BORIS DOI: |
10.7892/boris.90719 |
URI: |
https://boris.unibe.ch/id/eprint/90719 |
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