Older Candidates for Subthalamic Deep Brain Stimulation in Parkinson's Disease Have a Higher Incidence of Psychiatric Serious Adverse Events.

Cozac, Vitalii V; Ehrensperger, Michael M; Gschwandtner, Ute; Hatz, Florian; Meyer, Antonia; Monsch, Andreas U; Schüpbach, Michael; Taub, Ethan; Fuhr, Peter (2016). Older Candidates for Subthalamic Deep Brain Stimulation in Parkinson's Disease Have a Higher Incidence of Psychiatric Serious Adverse Events. Frontiers in aging neuroscience, 8(132), p. 132. Frontiers Research Foundation 10.3389/fnagi.2016.00132

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OBJECTIVE To investigate the incidence of serious adverse events (SAE) of subthalamic deep brain stimulation (STN-DBS) in elderly patients with Parkinson's disease (PD). METHODS We investigated a group of 26 patients with PD who underwent STN-DBS at mean age 63.2 ± 3.3 years. The operated patients from the EARLYSTIM study (mean age 52.9 ± 6.6) were used as a comparison group. Incidences of SAE were compared between these groups. RESULTS A higher incidence of psychosis and hallucinations was found in these elderly patients compared to the younger patients in the EARLYSTIM study (p < 0.01). CONCLUSIONS The higher incidence of STN-DBS-related psychiatric complications underscores the need for comprehensive psychiatric pre- and postoperative assessment in older DBS candidates. However, these psychiatric SAE were transient, and the benefits of DBS clearly outweighed its adverse effects.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DCR Unit Sahli Building > Forschungsgruppe Neurologie
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology

UniBE Contributor:

Schüpbach, Michael

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1663-4365

Publisher:

Frontiers Research Foundation

Language:

English

Submitter:

Stefanie Hetzenecker

Date Deposited:

13 Jan 2017 17:37

Last Modified:

15 Jan 2017 02:13

Publisher DOI:

10.3389/fnagi.2016.00132

PubMed ID:

27375478

Uncontrolled Keywords:

Parkinson's disease (PD); adverse events; age factors; deep brain stimulation (DBS); psychosis

BORIS DOI:

10.7892/boris.90719

URI:

https://boris.unibe.ch/id/eprint/90719

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