Monoaminergic control of brain states and sensory processing: Existing knowledge and recent insights obtained with optogenetics.

Lőrincz, Magor L; Adamantidis, Antoine Roger (2017). Monoaminergic control of brain states and sensory processing: Existing knowledge and recent insights obtained with optogenetics. Progress in neurobiology, 151, pp. 237-253. Elsevier 10.1016/j.pneurobio.2016.09.003

Text 1-s2.0-S030100821630034X-main.pdf - Published Version Restricted to registered users only Available under License Publisher holds Copyright. Download (2MB)

Monoamines are key neuromodulators involved in a variety of physiological and pathological brain functions. Classical studies using physiological and pharmacological tools have revealed several essential aspects of monoaminergic involvement in regulating the sleep-wake cycle and influencing sensory responses but many features have remained elusive due to technical limitations. The application of optogenetic tools led to the ability of monitoring and controlling neuronal populations with unprecedented temporal precision and neurochemical specificity. Here, we focus on recent advances in revealing the roles of some monoamines in brain state control and sensory information processing. We summarize the central position of monoamines in integrating sensory processing across sleep-wake states with an emphasis on research conducted using optogenetic techniques. Finally, we discuss the limitations and perspectives of new integrated experimental approaches in understanding the modulatory mechanisms of monoaminergic systems in the mammalian brain.

Interest & Impact

Downloads

2 since deposited on 19 Jan 2017
0 in the past 12 months

Citations

5 Citations in Web of Science ®
6 Citations in Scopus

Search

in Google Scholar™

Services

Actions (login required)

Edit item

Actions (login required)

Edit item