Monoaminergic control of brain states and sensory processing: Existing knowledge and recent insights obtained with optogenetics.

Lőrincz, Magor L; Adamantidis, Antoine Roger (2017). Monoaminergic control of brain states and sensory processing: Existing knowledge and recent insights obtained with optogenetics. Progress in neurobiology, 151, pp. 237-253. Elsevier 10.1016/j.pneurobio.2016.09.003

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Monoamines are key neuromodulators involved in a variety of physiological and pathological brain functions. Classical studies using physiological and pharmacological tools have revealed several essential aspects of monoaminergic involvement in regulating the sleep-wake cycle and influencing sensory responses but many features have remained elusive due to technical limitations. The application of optogenetic tools led to the ability of monitoring and controlling neuronal populations with unprecedented temporal precision and neurochemical specificity. Here, we focus on recent advances in revealing the roles of some monoamines in brain state control and sensory information processing. We summarize the central position of monoamines in integrating sensory processing across sleep-wake states with an emphasis on research conducted using optogenetic techniques. Finally, we discuss the limitations and perspectives of new integrated experimental approaches in understanding the modulatory mechanisms of monoaminergic systems in the mammalian brain.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DCR Unit Sahli Building > Forschungsgruppe Neurologie
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology

UniBE Contributor:

Adamantidis, Antoine Roger

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1873-5118

Publisher:

Elsevier

Language:

English

Submitter:

Stefanie Hetzenecker

Date Deposited:

19 Jan 2017 12:05

Last Modified:

03 Apr 2017 01:30

Publisher DOI:

10.1016/j.pneurobio.2016.09.003

PubMed ID:

27634227

Uncontrolled Keywords:

Brain states; Dopamine; Histamine; Noradrenaline; Sensory coding; Serotonin

BORIS DOI:

10.7892/boris.90722

URI:

https://boris.unibe.ch/id/eprint/90722

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