Abnormal coupling between DMN and delta and beta band EEG in psychotic patients

Bänninger, Anja; Palzes, Vanessa A; Roach, Brian J; Mathalon, Daniel H; Ford, Judith; König, Thomas (2017). Abnormal coupling between DMN and delta and beta band EEG in psychotic patients. Brain connectivity, 7(1), pp. 34-44. Mary Ann Liebert 10.1089/brain.2016.0456

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Common-phase synchronization of neuronal oscillations is a mechanism by which distributed brain regions can be integrated into transiently stable networks. Based on the hypothesis that schizophrenia is characterized by deficits in functional integration within neuronal networks, this study aimed to explore whether psychotic patients exhibit differences in brain regions involved in integrative mechanisms. We report an EEG-informed fMRI analysis of eyes-open resting state data collected from patients and healthy controls at two study sites. Global field synchronization (GFS) was chosen as an EEG measure indicating common-phase synchronization across electrodes. Several brain clusters appeared to be coupled to GFS differently in patients and controls: Activation in brain areas belonging to the default mode network (DMN) were negatively associated to GFS delta (1 - 3.5Hz) and positively to GFS beta (13 - 30Hz) bands in patients, whereas controls showed an opposite pattern for both GFS frequency bands in those regions; activation in extrastriate visual cortex was inversely related to GFS alpha1 (8.5 - 10.5Hz) band in healthy controls, while patients had a tendency towards a positive relationship. Taken together, the GFS measure might be useful for detecting additional aspects of deficient functional network integration in psychosis.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Translational Research Center
04 Faculty of Medicine > University Psychiatric Services

Graduate School:

Graduate School for Health Sciences (GHS)

UniBE Contributor:

Bänninger, Anja and König, Thomas

Subjects:

500 Science > 570 Life sciences; biology

ISSN:

2158-0014

Publisher:

Mary Ann Liebert

Language:

English

Submitter:

Thomas König

Date Deposited:

22 Dec 2016 09:22

Last Modified:

20 Dec 2017 09:29

Publisher DOI:

10.1089/brain.2016.0456

PubMed ID:

27897031

Uncontrolled Keywords:

Brain networks, Phase synchronization, Psychosis, Resting state, Simultaneous recordings

BORIS DOI:

10.7892/boris.91073

URI:

https://boris.unibe.ch/id/eprint/91073

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