Small angle x-ray scattering with edge-illumination.

Modregger, Peter; Cremona, Tiziana Patrizia; Benarafa, Charaf; Schittny, Johannes C; Olivo, Alessandro; Endrizzi, Marco (2016). Small angle x-ray scattering with edge-illumination. Scientific Reports, 6(30940), p. 30940. Nature Publishing Group 10.1038/srep30940

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Sensitivity to sub-pixel sample features has been demonstrated as a valuable capability of phase contrast x-ray imaging. Here, we report on a method to obtain angular-resolved small angle x-ray scattering distributions with edge-illumination- based imaging utilizing incoherent illumination from an x-ray tube. Our approach provides both the three established image modalities (absorption, differential phase and scatter strength), plus a number of additional contrasts related to unresolved sample features. The complementarity of these contrasts is experimentally validated by using different materials in powder form. As a significant application example we show that the extended complementary contrasts could allow the diagnosis of pulmonary emphysema in a murine model. In support of this, we demonstrate that the properties of the retrieved scattering distributions are consistent with the expectation of increased feature sizes related to pulmonary emphysema. Combined with the simplicity of implementation of edge-illumination, these findings suggest a high potential for exploiting extended sub-pixel contrasts in the diagnosis of lung diseases and beyond.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Anatomy
04 Faculty of Medicine > Pre-clinic Human Medicine > Theodor Kocher Institute

UniBE Contributor:

Cremona, Tiziana Patrizia; Benarafa, Charaf and Schittny, Johannes

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISSN:

2045-2322

Publisher:

Nature Publishing Group

Language:

English

Submitter:

Johannes Schittny

Date Deposited:

12 Dec 2016 10:16

Last Modified:

15 Jan 2017 02:13

Publisher DOI:

10.1038/srep30940

PubMed ID:

27491917

BORIS DOI:

10.7892/boris.91138

URI:

https://boris.unibe.ch/id/eprint/91138

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