The Changing Role of the Clinical Microbiology Laboratory in Defining Resistance in Gram-negatives.

Endimiani, Andrea; Jacobs, Michael R (2016). The Changing Role of the Clinical Microbiology Laboratory in Defining Resistance in Gram-negatives. Infectious disease clinics of North America, 30(2), pp. 323-345. Elsevier 10.1016/j.idc.2016.02.002

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The evolution of resistance in Gram-negatives has challenged the clinical microbiology laboratory to implement new methods for their detection. Multidrug-resistant strains present major challenges to conventional and new detection methods. More rapid pathogen identification and antimicrobial susceptibility testing have been developed for use directly on specimens, including fluorescence in situ hybridization tests, automated polymerase chain reaction systems, microarrays, mass spectroscopy, next-generation sequencing, and microfluidics. Review of these methods shows the advances that have been made in rapid detection of resistance in cultures, but limited progress in direct detection from specimens.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases

UniBE Contributor:

Endimiani, Andrea

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISSN:

0891-5520

Publisher:

Elsevier

Funders:

[4] Swiss National Science Foundation

Projects:

[577] SNF project 153377 to Andrea Endimiani

Language:

English

Submitter:

Andrea Endimiani

Date Deposited:

06 Jan 2017 14:55

Last Modified:

09 Sep 2017 18:47

Publisher DOI:

10.1016/j.idc.2016.02.002

PubMed ID:

27208762

Web of Science ID:

000378466900003

Uncontrolled Keywords:

AST; LAMP; MALDI-TOF; Microarray; PCR; Rapid; Real time; Sequencing

BORIS DOI:

10.7892/boris.91231

URI:

https://boris.unibe.ch/id/eprint/91231

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