Effects of Erosion Protocol Design on Erosion/Abrasion Study Outcome and on Active Agent (NaF and SnF2) Efficacy.

Schlüter, Nadine; Lussi, Adrian; Tolle, Alexandra; Ganss, Carolina (2016). Effects of Erosion Protocol Design on Erosion/Abrasion Study Outcome and on Active Agent (NaF and SnF2) Efficacy. Caries research, 50(2), pp. 170-179. Karger 10.1159/000445169

[img] Text
Effects of Erosion Protocol Design on Erosion_Abrasion Study Outcome and on Active Agent (NaF and SnF2) Efficacy.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (171kB) | Request a copy

There is no standard for testing anti-erosive/anti-abrasive agents, making the assessment and comparison of study results difficult. Factors which are varied in study designs are amongst others the erosive medium regarding concentration and pH or movement type of acid. The present study therefore investigated the impact of these factors on dimension of tissue loss and on efficacy of active agents used as anti-erosive/anti-abrasive therapeutics. In 8 experiments, consisting of 8 groups each (n = 20 each), resulting in a total of 64 groups, enamel specimens were demineralised (10 days, 6 × 2 min/day) using different acids (1, 0.5 and 0.3% citric acid at native pH 2.3, 2.5 and 2.8, respectively, and 0.3% citric acid adjusted to pH 3.6) with two different movement types (jerky or smooth). Specimens were immersed (2 × 2 min/day) in slurries of 1,450 ppm F- toothpaste (NaF), 1,450 ppm F- and 3,436 ppm Sn2+ toothpaste (NaF/SnF2), 970 ppm F- and 3,000 ppm Sn2+ gel (SnF2) or placebo, or were additionally brushed during immersion (15 s, 200 g). All groups were in between stored in a mineral salt solution. Tissue loss was determined profilometrically. Movement type, pH and concentration of acid had a substantial impact on study outcome. The combination of jerky movement and concentrated acid masked, to some extent, differences between erosive and erosive-abrasive tissue loss. The acid at low concentration (0.3%), independent of pH, was too mild to produce any tissue loss. The model with the best ability to demonstrate effects of abrasive impacts and active agents used the 1% acid concentration combined with smooth acid movements.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > School of Dental Medicine
04 Faculty of Medicine > School of Dental Medicine > Department of Preventive, Restorative and Pediatric Dentistry

UniBE Contributor:

Schlüter, Nadine and Lussi, Adrian

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0008-6568

Publisher:

Karger

Language:

English

Submitter:

Eveline Carmen Schuler

Date Deposited:

08 Mar 2017 10:11

Last Modified:

09 Sep 2017 18:44

Publisher DOI:

10.1159/000445169

PubMed ID:

27115419

Uncontrolled Keywords:

Abrasion; Citric acid; Enamel; Erosion; Fluoride; Study design; Tin

BORIS DOI:

10.7892/boris.91599

URI:

https://boris.unibe.ch/id/eprint/91599

Actions (login required)

Edit item Edit item
Provide Feedback