Cyclopentenone-containing oxidized phospholipids and their isoprostanes as pro-resolving mediators of inflammation.

Friedli, Olivier; Freigang, Stefan Bernd (2017). Cyclopentenone-containing oxidized phospholipids and their isoprostanes as pro-resolving mediators of inflammation. Biochimica and biophysica acta - molecular and cell biology of lipids, 1862(4), pp. 382-392. Elsevier 10.1016/j.bbalip.2016.07.006

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Inflammation represents a powerful innate immune response that defends tissue homeostasis. However, the appropriate termination of inflammatory processes is essential to prevent the development of chronic inflammatory disorders. The resolution of inflammation is actively induced by specialized pro-resolving lipid mediators, which include eicosanoids, resolvins, protectins and maresins. The responsible pro-resolution pathways have emerged as promising targets for anti-inflammatory therapies since they mitigate excessive inflammation without compromising the anti-microbial defenses of the host. We have recently shown that the lipid peroxidation of membrane phospholipids, which is associated with inflammatory conditions, generates oxidized phospholipid (OxPL) species with potent pro-resolving activities. These pro-resolving OxPLs contain a cyclopentenone as their common determinant, and are structurally and functionally related to endogenous pro-resolving prostaglandins. Here, we review the regulation of inflammatory responses by OxPLs with particular focus on the bioactivities and structural characteristics of cyclopentenone-OxPLs, and discuss the impact of the responsible signaling pathways on inflammatory diseases. This article is part of a Special Issue entitled: Lipid modification and lipid peroxidation products in innate immunity and inflammation edited by Christoph J. Binder.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute of Pathology > Inflammatory Pathology
04 Faculty of Medicine > Service Sector > Institute of Pathology
04 Faculty of Medicine > Service Sector > Institute of Pathology > Immunopathology

Graduate School:

Graduate School for Cellular and Biomedical Sciences (GCB)

UniBE Contributor:

Friedli, Olivier and Freigang, Stefan Bernd

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISSN:

1388-1981

Publisher:

Elsevier

Language:

English

Submitter:

Stefan Bernd Freigang

Date Deposited:

22 Dec 2016 08:25

Last Modified:

10 Feb 2017 01:31

Publisher DOI:

10.1016/j.bbalip.2016.07.006

PubMed ID:

27422370

Uncontrolled Keywords:

Cyclopentenone; Inflammation; Isoprostane; Nrf2; Oxidized phospholipid; Resolution

BORIS DOI:

10.7892/boris.91603

URI:

https://boris.unibe.ch/id/eprint/91603

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