Morphological Aspects of Tumor Angiogenesis.

Hlushchuk, Ruslan; Barré, Sébastien; Djonov, Valentin (2016). Morphological Aspects of Tumor Angiogenesis. Methods in molecular biology, 1464, pp. 13-24. Humana Press 10.1007/978-1-4939-3999-2_2

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The tumor vasculature is a chaotic mixture of abnormal, hierarchically disorganized vessels that differ from those of normal tissues with respect to organization, structure and function. Firstly, tumor vessel wall structure is abnormal and heterogeneous within the tumor. Besides contractile wall components, the perivascular compartment is often lacking pericytes, what makes the tumor vessels fragile and leaky. Secondly, another group of abnormalities involves distortions in angioarchitecture and vasculature as network. Common features of tumor vessels, irrespective of their origin, size and growth pattern, are absence of hierarchical organization, formation of vessels with irregular contours and their heterogeneous distribution within the tumor.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Anatomy
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Anatomy > Topographical and Clinical Anatomy

UniBE Contributor:

Hlushchuk, Ruslan; Barré, Sébastien and Djonov, Valentin Georgiev


600 Technology > 610 Medicine & health
500 Science > 570 Life sciences; biology




Humana Press




David Christian Haberthür

Date Deposited:

28 Dec 2016 12:01

Last Modified:

15 Dec 2020 07:46

Publisher DOI:


PubMed ID:


Uncontrolled Keywords:

Angiogenesis; Anti-angiogenesis; Quantification of tumorangiogenesis; Tumor growth; Tumorangiogenesis


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