Additional malignancies in patients with neuroendocrine tumours: analysis of the SwissNET registry.

Kollár, Attila; Blank, Annika; Perren, Aurel; Bütikofer, Lukas; Stettler, Christoph; Christ, Emanuel (2016). Additional malignancies in patients with neuroendocrine tumours: analysis of the SwissNET registry. Swiss medical weekly, 146, w14362. EMH Schweizerischer Ärzteverlag 10.4414/smw.2016.14362

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PRINCIPLES Neuroendocrine neoplasms (NENs) are believed to be associated with an increased risk for additional malignancies (AMs). We aimed to (1) assess the occurrence of AM in NEN patients (2) investigate the characteristics and temporal relationship of NEN patients with and without AM. METHODS The SwissNET registry has prospectively documented patients with NEN since 2008, covering the entire area of Switzerland. Clinical characteristics, functionality, location and histology of NEN as well as survival of all consecutive patients were retrieved. The characteristics of the AM (location, histology, time point of diagnosis in relation to diagnosis of NEN) were extracted. RESULTS Out of 934 patients, 193 patients (21%) presented with AMs. There was no statistically significant difference with regard to location, functionality and grading (G1-G3) between the NEN patients with and without AM. AMs were diagnosed synchronously (±3 months), before (>-3 months) and after (>+3 months) diagnosis of NEN in 82 (42%), 96 (50%) and 13 (7%) patients, respectively. Location of NEN correlated with the anatomical origin of the AM. Age- and gender- corrected survival was not significantly different between NEN patients with and without AM. CONCLUSION The prevalence of AM in NEN is high. The comparable characteristics with regard to functionality and grading in the NEN cohorts with and without AM and the similar location of AM and NEN suggest a selection bias towards frequent imaging procedures in NEN patients with AM.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute of Pathology > Clinical Pathology
04 Faculty of Medicine > Pre-clinic Human Medicine > CTU Bern
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Endocrinology, Diabetology and Clinical Nutrition
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Medical Oncology
04 Faculty of Medicine > Service Sector > Institute of Pathology

UniBE Contributor:

Kollár, Attila; Blank, Annika; Perren, Aurel; Bütikofer, Lukas; Stettler, Christoph and Christ, Emanuel

Subjects:

600 Technology > 610 Medicine & health
500 Science > 570 Life sciences; biology

ISSN:

1424-7860

Publisher:

EMH Schweizerischer Ärzteverlag

Language:

English

Submitter:

Aurel Perren

Date Deposited:

21 Dec 2016 16:08

Last Modified:

11 May 2017 14:56

Publisher DOI:

10.4414/smw.2016.14362

PubMed ID:

27878790

BORIS DOI:

10.7892/boris.91970

URI:

https://boris.unibe.ch/id/eprint/91970

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