Cytokine-Induced Modulation of Colorectal Cancer.

Mager, Lukas; Wasmer, Marie-Hélène; Rau, Tilman; Krebs, Philippe (2016). Cytokine-Induced Modulation of Colorectal Cancer. Frontiers in oncology, 6(96), p. 96. Frontiers Research Foundation 10.3389/fonc.2016.00096

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The emergence of novel immunomodulatory cancer therapies over the last decade, above all immune checkpoint blockade, has significantly advanced tumor treatment. For colorectal cancer (CRC), a novel scoring system based on the immune cell infiltration in tumors has greatly improved disease prognostic evaluation and guidance to more specific therapy. These findings underline the relevance of tumor immunology in the future handling and therapeutic approach of malignant disease. Inflammation can either promote or suppress CRC pathogenesis and inflammatory mediators, mainly cytokines, critically determine the pro- or anti-tumorigenic signals within the tumor environment. Here, we review the current knowledge on the cytokines known to be critically involved in CRC development and illustrate their mechanisms of action. We also highlight similarities and differences between CRC patients and murine models of CRC and point out cytokines with an ambivalent role for intestinal cancer. We also identify some of the future challenges in the field that should be addressed for the development of more effective immunomodulatory therapies.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute of Pathology > Inflammatory Pathology
04 Faculty of Medicine > Service Sector > Institute of Pathology > Clinical Pathology
04 Faculty of Medicine > Service Sector > Institute of Pathology
04 Faculty of Medicine > Service Sector > Institute of Pathology > Immunopathology
04 Faculty of Medicine > Service Sector > Institute of Pathology > Tumour Pathology

Graduate School:

Graduate School for Cellular and Biomedical Sciences (GCB)

UniBE Contributor:

Mager, Lukas; Wasmer, Marie-Hélène; Rau, Tilman and Krebs, Philippe

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISSN:

2234-943X

Publisher:

Frontiers Research Foundation

Funders:

[UNSPECIFIED] Swiss National Science Foundation
[UNSPECIFIED] Bern University Research Foundation
[UNSPECIFIED] San Salvatore Foundation
[UNSPECIFIED] Foundation Johanna Duermueller-Bol
[UNSPECIFIED] Gertrud-Hagmann Foundation for Malignoma Research

Language:

English

Submitter:

Philippe Krebs

Date Deposited:

21 Dec 2016 15:07

Last Modified:

27 Sep 2017 17:16

Publisher DOI:

10.3389/fonc.2016.00096

PubMed ID:

27148488

Uncontrolled Keywords:

biomarker; colorectal cancer; cytokine; inflammation; tumor microenvironment

BORIS DOI:

10.7892/boris.91988

URI:

https://boris.unibe.ch/id/eprint/91988

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