Autologous stem cell transplantation in elderly patients with multiple myeloma: evaluation of its safety and efficacy.

Stettler, Jasmin; Novak, Urban; Baerlocher, Gabriela M.; Seipel, Katja; Mansouri Taleghani, Behrouz; Pabst, Thomas (2017). Autologous stem cell transplantation in elderly patients with multiple myeloma: evaluation of its safety and efficacy. Leukemia & lymphoma, 58(5), pp. 1076-1083. Informa Healthcare 10.1080/10428194.2016.1233542

[img]
Preview
Text
Manuscript_Stettler et al_myeloma in the elderly_June 3 2016_final_wo Tables.pdf - Accepted Version
Available under License Publisher holds Copyright.

Download (257kB) | Preview

Administering high-dose chemotherapy (HDCT) with melphalan to elderly myeloma patients represents a challenge with respect to achieving therapeutic efficacy whilst avoiding significant toxicity. We analyzed safety and efficacy of HDCT in 61 elderly myeloma patients older than 65 years, including 12 patients ≥70 years, and compared them with 237 MM patients below 65 years treated in the same period. We observed no differences in the time until neutrophil recovery, infection rate, and treatment related mortality until 100 days after ASCT. Furthermore, higher age was not associated with inferior progression-free and overall survival at 1 and 2 years after ASCT. However, MM patients older than 70 years had a longer duration of hospitalization (26 vs. 20 days; p= .0001) and a longer time until platelet recovery >20G/L (20 vs. 13 days; p= .0007). Our data suggest that HDCT with ASCT is feasible, safe and effective in MM patients older than 65 years.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Haematology and Central Haematological Laboratory
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Unit Childrens Hospital > Forschungsgruppe Hämatologie (Erwachsene)
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Medical Oncology

UniBE Contributor:

Novak, Urban; Baerlocher, Gabriela M.; Seipel, Katja; Mansouri Taleghani, Behrouz and Pabst, Thomas

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1042-8194

Publisher:

Informa Healthcare

Language:

English

Submitter:

Marianne Zahn

Date Deposited:

23 Dec 2016 14:51

Last Modified:

27 Oct 2017 09:58

Publisher DOI:

10.1080/10428194.2016.1233542

PubMed ID:

27736269

Uncontrolled Keywords:

Myeloma; autologous; efficacy; elderly; high-dose chemotherapy; prognosis; safety; stem cell; survival; transplant

BORIS DOI:

10.7892/boris.92007

URI:

https://boris.unibe.ch/id/eprint/92007

Actions (login required)

Edit item Edit item
Provide Feedback