Lung morphometry: the link between structure and function.

Weibel, Ewald Rudolf (2017). Lung morphometry: the link between structure and function. Cell and tissue research, 367(3), pp. 413-426. Springer 10.1007/s00441-016-2541-4

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The study of the structural basis of gas exchange function in the lung depends on the availability of quantitative information that concerns the structures establishing contact between the air in the alveoli and the blood in the alveolar capillaries, which can be entered into physiological equations for predicting oxygen uptake. This information is provided by morphometric studies involving stereological methods and allows estimates of the pulmonary diffusing capacity of the human lung that agree, in experimental studies, with the maximal oxygen consumption. The basis for this "machine lung" structure lies in the complex design of the cells building an extensive air-blood barrier with minimal cell mass.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Anatomy

UniBE Contributor:

Weibel, Ewald Rudolf

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0302-766X

Publisher:

Springer

Language:

English

Submitter:

Benoît Zuber

Date Deposited:

28 Dec 2016 09:58

Last Modified:

24 Feb 2017 01:31

Publisher DOI:

10.1007/s00441-016-2541-4

PubMed ID:

27981379

Uncontrolled Keywords:

Alveolar cells; Alveolar epithelium; Capillary endothelium; Gas exchange; Lung morphometry

BORIS DOI:

10.7892/boris.92034

URI:

https://boris.unibe.ch/id/eprint/92034

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