Autophagy and its current relevance to the diagnosis and clinical management of esophageal diseases.

Langer, Rupert; Streutker, Catherine J; Swanson, Paul E (2016). Autophagy and its current relevance to the diagnosis and clinical management of esophageal diseases. Annals of the New York Academy of Sciences, 1381(1), pp. 113-121. Wiley 10.1111/nyas.13190

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Autophagy is an evolutionarily conserved cell survival program that degrades dysfunctional organelles and misfolded or long-lived proteins through the formation of lysosomes. Basal autophagy helps to maintain cellular homeostasis, while additional autophagy can be induced under cellular stress conditions. Autophagy has shown to be involved in a variety of diseases, such as inflammation, autoimmune diseases, degeneration, and cancer. We review the relevance of autophagy to the diagnosis and clinical management of esophageal diseases with the following questions in mind. What is autophagy and can/should we detect it in routine pathology specimens? What is the role of autophagy in gastroesophageal reflux disease/inflammatory esophageal disease? What role may autophagy play in the interaction between pro- and antiapoptotic pathways in esophageal malignancies and treatment?

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute of Pathology

UniBE Contributor:

Langer, Rupert

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISSN:

0077-8923

Publisher:

Wiley

Language:

English

Submitter:

Doris Haefelin

Date Deposited:

22 Dec 2016 14:45

Last Modified:

27 Sep 2017 18:35

Publisher DOI:

10.1111/nyas.13190

PubMed ID:

27526024

Uncontrolled Keywords:

autophagy; carcinoma; esophagus; immunohistochemistry; inflammation

BORIS DOI:

10.7892/boris.92052

URI:

https://boris.unibe.ch/id/eprint/92052

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