Motivation and mortality in older women with early stage breast cancer: A longitudinal study with ten years of follow-up.

Dumontier, Clark; Clough-Gorr, Kerri M; Silliman, Rebecca A; Stuck, Andreas E; Moser, André (2017). Motivation and mortality in older women with early stage breast cancer: A longitudinal study with ten years of follow-up. Journal of geriatric oncology, 8(2), pp. 133-139. Elsevier 10.1016/j.jgo.2016.12.002

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OBJECTIVES The Getting Out of Bed Scale (GOB) was validated as a health-related quality of life (HRQoL) variable in older women with early stage breast cancer, suggesting its potential as a concise yet powerful measure of motivation. The aim of our project was to assess the association between GOB and mortality over 10years of follow-up. MATERIALS AND METHODS We studied 660 women ≥65-years old diagnosed with stage I-IIIA primary breast cancer. Data were collected over 10years of follow-up from interviews, medical records, and death indexes. RESULTS Compared to women with lower GOB scores, women with higher GOB had an unadjusted hazard ratio (HR) of all-cause mortality of 0.78 at 5years, 95% confidence interval (CI) (0.52, 1.19) and 0.77 at 10years, 95%CI (0.59, 1.00). These associations diminished after adjusting for age and stage of breast cancer, and further after adjusting for other HRQoL variables including physical function, mental health, emotional health, psychosocial function, and social support. Unadjusted HRs of breast cancer-specific mortality were 0.92, 95%CI (0.49, 1.74), at 5years, and 0.82, 95%CI (0.52, 1.32), at 10years. These associations also decreased in adjusted models. CONCLUSION Women with higher GOB scores had a lower hazard of all-cause mortality in unadjusted analysis. This effect diminished after adjusting for confounding clinical and HRQoL variables. GOB is a measure of motivation that may not be independently associated with cancer mortality, but reflects other HRQoL variables making it a potential outcome to monitor in older patients with cancer.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine (ISPM)
04 Faculty of Medicine > Department of General Internal Medicine (DAIM) > Geriatric Clinic > Geriatric Clinic Inselspital

UniBE Contributor:

Clough, Kerri; Stuck, Andreas and Moser, André


600 Technology > 610 Medicine & health
300 Social sciences, sociology & anthropology > 360 Social problems & social services








Doris Kopp Heim

Date Deposited:

22 Dec 2016 15:58

Last Modified:

14 Feb 2019 08:51

Publisher DOI:


PubMed ID:


Uncontrolled Keywords:

Breast cancer; Disease-specific mortality; Geriatric oncology; Health-related quality of life; Mortality; Motivation; Quality of life; Risk stratification; Survivorship




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